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Natural Language Processing Identifies Symptoms Predicting Complete Coronary Artery Occlusion in Patients with NSTEMI. 自然语言处理识别预测NSTEMI患者完全冠状动脉闭塞的症状。
IF 3.9 Pub Date : 2026-02-06 DOI: 10.1093/eurjcn/zvag011
Dillon J Dzikowicz, Chi-Ju Lai, Sankalp Babarao Saoji, Jessica K Zègre-Hemsey, Holli A DeVon, Linwei Wang, Wojciech Zareba

Aim: One in ten patients present to the emergency department (ED) with symptoms of acute coronary syndrome (ACS). The 13-item ACS Symptom Checklist is a validated tool for rapid ACS symptom assessment. We aimed to evaluate the effectiveness of the 13-item ACS Symptom Checklist in distinguishing NSTEMI patients with and without an occluded artery using natural language processing (NLP).

Methods and results: We retrospectively extracted the 13 symptoms from the 13-item ACS Symptom Checklist for all patients admitted with NSTEMI. The outcome was an occluding coronary artery defined as one requiring revascularization. We applied Chi-square tests to assess the sensitivity and specificity of each symptom for an acutely occluded coronary artery. We used logistic regression models stratified by sex to measure the odds of an occluded artery after controlling for age, obesity, and diabetes. The majority of the 1905 patients were male (63.1%), older (66±12 years), and White (84%). Twenty-three percent of patients require revascularization. Common comorbidities included diabetes (17%) and obesity (42%). Symptoms differentiating patients with and without an occluded artery included palpitations (22.4% vs. 29.0%), arm pain (23.5% vs. 16.5%), unusual fatigue (19.1% vs. 3.3%), and lightheadedness (21.1% vs. 26.5%). Arm pain was associated with 1.532 (95% CI 1.155-2.033) increased odds of an occluded artery, with similar odds in men and women.

Conclusion: Arm pain was the primary symptom predicting an occluded coronary artery in NSTEMI patients; of note, there were minimal sex differences. NLP was a useful tool for identifying arm pain and other symptoms from clinical notes.

目的:十分之一的患者目前到急诊科(ED)的急性冠状动脉综合征(ACS)的症状。13项ACS症状检查表是快速评估ACS症状的有效工具。我们的目的是评估13项ACS症状检查表在使用自然语言处理(NLP)区分有和没有动脉闭塞的NSTEMI患者中的有效性。方法和结果:我们回顾性地从13项ACS症状清单中提取了所有入院的NSTEMI患者的13项症状。结果是冠状动脉闭塞,定义为需要血运重建术。我们应用卡方检验来评估急性冠状动脉闭塞的每个症状的敏感性和特异性。在控制了年龄、肥胖和糖尿病因素后,我们使用按性别分层的逻辑回归模型来测量动脉闭塞的几率。1905例患者以男性(63.1%)、老年(66±12岁)、白人(84%)居多。23%的患者需要血管重建术。常见的合并症包括糖尿病(17%)和肥胖(42%)。区分有无动脉闭塞患者的症状包括心悸(22.4%对29.0%)、手臂疼痛(23.5%对16.5%)、异常疲劳(19.1%对3.3%)和头晕(21.1%对26.5%)。手臂疼痛与动脉闭塞的几率增加1.532 (95% CI 1.155-2.033)相关,男性和女性的几率相似。结论:手臂疼痛是预测NSTEMI患者冠状动脉闭塞的主要症状;值得注意的是,性别差异很小。NLP是从临床记录中识别手臂疼痛和其他症状的有用工具。
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引用次数: 0
Exploring the experience and management of thirst in patients with heart failure: a qualitative study from patients and nurses. 探讨心力衰竭患者口渴的体验和管理:一项来自患者和护士的定性研究。
IF 3.9 Pub Date : 2026-02-04 DOI: 10.1093/eurjcn/zvaf253
Yingjun Zheng, Qiongshan Chen, Xuehui Yang, Hui Liu

Aims: To explore the experience and management of thirst in patients with heart failure and the cardiovascular nurses involved in their care.

Methods and results: This qualitative exploratory study used purposive sampling to select patients with heart failure and cardiovascular nurses. One-on-one, semi-structured interviews were conducted, and data were analyzed using reflexive thematic analysis. Interviews were conducted with 12 patients with heart failure and 11 nurses. Three major themes with eleven sub-themes were identified: (1) The multidimensional burden of thirst (frequent and prolonged symptoms, physical discomfort, and emotional distress); (2) the interplay of innovative and traditional approaches (alleviation through drinking water, modifying behavioural habits, seeking help from Traditional Chinese Medicine (TCM), and utilizing various aids); and (3) barriers and needs in thirst management (thirst is perceived as minor compared to other symptoms, thirst is challenging to recognize, the need for standardized assessment, and the need for knowledge empowerment).

Conclusion: This qualitative study highlights the significant burden of thirst in patients with heart failure and the critical need for improved thirst management. These findings have implications for healthcare providers in developing an environment that supports effective thirst management.

目的:探讨心力衰竭患者口渴的护理经验及处理方法。方法与结果:采用有目的抽样的方法,对心衰患者和心血管护理人员进行定性探索性研究。进行了一对一的半结构化访谈,并使用反身性主题分析对数据进行了分析。对12例心力衰竭患者和11名护理人员进行了访谈。确定了三个主要主题和十一个副主题:(1)口渴的多维负担(频繁和持久的症状,身体不适和情绪困扰);(2)创新方法与传统方法(饮水缓解、改变行为习惯、寻求中医帮助、利用各种辅助手段)的相互作用;(3)口渴管理方面的障碍和需求(与其他症状相比,口渴被认为是次要的,口渴很难识别,需要标准化评估,需要知识赋权)。结论:本定性研究强调了心力衰竭患者口渴的显著负担和改善口渴管理的迫切需要。这些发现对医疗保健提供者开发支持有效口渴管理的环境具有启示意义。
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引用次数: 0
The Long-Term Effects of Aerobic Exercise Training in Patients with Peripheral Arterial Disease: A Systematic Review. 外周动脉疾病患者有氧运动训练的长期影响:一项系统综述。
IF 3.9 Pub Date : 2026-02-03 DOI: 10.1093/eurjcn/zvag037
Aynur Demirel, Gamze Nur Ahiskali, Hidaye Yamikan, Ebru Calik

Aims: Aerobic exercise (AE) is a cornerstone of management for patients with peripheral arterial disease (PAD) due to its benefits for functional capacity and quality of life. While the short-term effects of AE therapy are well documented, the long-term effects remain unclear. Therefore, this study aimed to investigate the long-term effects of aerobic exercise training in patients with PAD.

Methods and results: A search of six electronic databases from inception to December 2024 was conducted, and studies were screened using the Rayyan AI tool. Randomized controlled trials involving AE interventions lasting more than 8 weeks with a follow-up period of any length were included. Risk of bias and methodological quality were assessed using the Cochrane Collaboration's risk of bias tool and the PEDro Scale, respectively. Six randomized controlled trials involving a total of 2,233 participants were included. Strong evidence indicates that improvements in physical activity levels achieved with lower extremity AE training are not maintained in the long term. However, there is conflicting evidence regarding the long-term maintenance of walking ability, functional status, mobility, and quality of life, as well as weak evidence for improvements in anxiety, depression, and self-efficacy. A meta-analysis could not be conducted due to substantial variation in outcome measures among the included studies.

Conclusion: This systematic review indicates that the benefits of lower extremity AE training are not maintained at expected levels over the long term. Therefore, it is crucial to promote exercise as a lifelong habit and implement community-based exercise strategies for patients with PAD.

Registration: PROSPERO CRD42024603996.

目的:有氧运动(AE)是外周动脉疾病(PAD)患者管理的基石,因为它有益于功能能力和生活质量。虽然AE治疗的短期效果已被充分证明,但其长期效果仍不清楚。因此,本研究旨在探讨有氧运动训练对PAD患者的长期影响。方法与结果:检索自成立至2024年12月的6个电子数据库,使用Rayyan AI工具对研究进行筛选。随机对照试验包括AE干预,持续时间超过8周,随访时间不限。分别使用Cochrane协作的偏倚风险工具和PEDro量表评估偏倚风险和方法学质量。六项随机对照试验共涉及2233名参与者。强有力的证据表明,通过下肢AE训练获得的体力活动水平的改善并不能长期维持。然而,关于长期维持行走能力、功能状态、活动能力和生活质量,以及改善焦虑、抑郁和自我效能的证据不足,存在相互矛盾的证据。由于纳入研究的结果测量存在很大差异,因此无法进行荟萃分析。结论:本系统综述表明,下肢AE训练的益处不能长期维持在预期水平。因此,促进运动成为PAD患者的终身习惯并实施基于社区的运动策略至关重要。注册号:PROSPERO CRD42024603996。
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引用次数: 0
AI Agent for Delirium Screening among Patients in Oncology and Cardiac Intensive Care Units: A Proof-of-Concept Study. 人工智能药物用于肿瘤和心脏重症监护病房患者谵妄筛查:一项概念验证研究
IF 3.9 Pub Date : 2026-02-03 DOI: 10.1093/eurjcn/zvag029
Yingchun Zeng, Hongxia Xie, Fen Gu, Jian Chen, Guolong Zhang, Xinjun Jiang, Siew Tiang Lau

Aim: To develop and evaluate an autonomous artificial intelligence (AI) agent to support nurse-led delirium screening and guideline-concordant prevention and management.

Methods and results: We constructed a delirium-specific knowledge graph from publicly available clinical guidelines and implemented an autonomous AI agent that integrates retrieval-augmented generation with validated delirium assessment tools to simulate decision-support in nursing workflows. In this proof-of-concept evaluation, the agent was benchmarked on 20 clinical patient cases to assess (i) tool selection accuracy, (ii) fidelity of clinical conclusions, and (iii) adherence to guideline-based delirium care recommendations. Human experts review rated coherence, relevance, and clinical interpretability of the outputs. The 20 cases were drawn from postoperative care (n=6), Cardiac Intensive Care Unit care (n=5), and cancer wards (n=9), including 6 males (30%) and 14 females (70%), with a mean age of 56.5 years (SD 17.9; range 21-82). Two experienced registered nurses independently validated the agent's outputs, benchmarked them against guideline-based recommendations. The agent achieved 100% accuracy in selecting appropriate tools, and 90% overall accuracy in generating conclusions and care recommendations, compared with 45% for other large language model baselines. Recommendations were presented in a structured, actionable format and aligned with guideline-based delirium care.

Conclusions: This proof-of-concept study suggests that an autonomous AI agent can deliver clinically interpretable, guideline-aligned delirium decision support and may help reduce missed or delayed recognition while standardizing nursing actions. Given the high delirium burden in cardiovascular pathways (e.g., cardiac ICUs and postoperative care), prospective validation in cardiovascular settings is warranted to evaluate clinical impact, safety, and workflow integration.

目的:开发和评估一种自主人工智能(AI)智能体,以支持护士主导的谵妄筛查和符合指南的预防和管理。方法和结果:我们从公开可用的临床指南中构建了一个谵妄特定知识图谱,并实现了一个自主AI代理,该代理集成了检索增强生成和经过验证的谵妄评估工具,以模拟护理工作流程中的决策支持。在这项概念验证评估中,该药物以20例临床患者为基准,以评估(i)工具选择的准确性,(ii)临床结论的保真度,以及(iii)对基于指南的谵妄护理建议的依从性。人类专家审查评级的一致性,相关性和临床可解释性的输出。20例患者分别来自术后护理(n=6)、心脏重症监护病房(n=5)和癌症病房(n=9),其中男性6例(30%),女性14例(70%),平均年龄56.5岁(SD 17.9;范围21-82)。两名经验丰富的注册护士独立验证了代理的输出,并根据基于指南的建议对其进行基准测试。智能体在选择合适的工具方面达到100%的准确率,在生成结论和护理建议方面达到90%的总体准确率,而其他大型语言模型基线的准确率为45%。建议以结构化、可操作的格式提出,并与基于指南的谵妄护理保持一致。结论:这项概念验证研究表明,自主人工智能代理可以提供临床可解释的、符合指南的谵妄决策支持,并可能有助于减少遗漏或延迟识别,同时标准化护理行动。考虑到心血管途径(如心脏重症监护室和术后护理)的高谵妄负担,有必要在心血管环境中进行前瞻性验证,以评估临床影响、安全性和工作流程整合。
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引用次数: 0
Advocacy spotlight series: Prof. Donna Fitzsimons. 倡导聚焦系列:唐娜·菲茨西蒙斯教授。
IF 3.9 Pub Date : 2026-02-03 DOI: 10.1093/eurjcn/zvag030
Shirley Ingram, Donna Fitzsimons
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引用次数: 0
The cardiac rehabilitation needs and preferences of women living in rural communities: a qualitative study of co-designing a women-focused cardiac rehabilitation program. 农村妇女心脏康复需求和偏好:共同设计以妇女为中心的心脏康复方案的定性研究
IF 3.9 Pub Date : 2026-02-02 DOI: 10.1093/eurjcn/zvag034
Orathai Suebkinorn, Alline Beleigoli, Claire Drummond, Lemlem G Gebremichael, Norma B Bulamu, Tania Marin, Lance C Dalleck, Sherry L Grace, Jeroen M Hendriks, Robyn A Clark, Joyce S Ramos

Aim: To identify the cardiac rehabilitation (CR) needs and preferences of women living in rural communities to inform the co-design of a women-focused web-based CR program.

Methods: Using a person-centred care and co-design approach, six 2-hour focus groups were conducted in-person or online across six rural regions of South Australia. Women with cardiovascular diseases who had completed a CR program were included. Discussions were directed using a semi-structured guide on the needs and preferences of women for different aspects of CR delivery. Data were transcribed verbatim, and thematic analysis was performed using NVivo.

Results: Nineteen women (mean age 65.1 years, ±12.3) participated in one of six focus groups. Six key themes emerged: (1) Navigating financial barriers to care; (2) Early education and support matter; (3) Recognising women's heart health needs; (4) Empowering women through exercise and physical activity; (5) The power of connection: valuing professional and personal support; and (6) Integrating technology for accessible and flexible care.

Conclusion: Women expressed openness to using a web-based program to access and facilitate early CR participation. Tailored educational and exercise components, delivered through a financially viable model and supported by CR nurses, were identified as essential to meet the needs and preferences of women in rural areas. These findings provide critical insights for developing inclusive and sustainable CR programs that address the unique needs of women in rural settings.

目的:确定生活在农村社区的妇女的心脏康复(CR)需求和偏好,为共同设计以妇女为中心的基于网络的CR项目提供信息。方法:采用以人为本的护理和共同设计方法,在南澳大利亚州的六个农村地区进行了6个2小时的面对面或在线焦点小组。患有心血管疾病的妇女完成了CR项目。讨论使用半结构化指南指导妇女在CR分娩的不同方面的需求和偏好。数据逐字转录,并使用NVivo进行专题分析。结果:19名女性(平均年龄65.1岁,±12.3岁)参加了6个焦点组中的一个。出现了六个关键主题:(1)克服医疗保健的财务障碍;(2)早期教育和支持事项;(3)认识到妇女的心脏健康需要;(4)通过锻炼和体育活动赋予妇女权力;(5)联系的力量:重视专业和个人支持;(6)整合技术以实现可获得和灵活的护理。结论:女性对使用基于网络的项目获取和促进早期CR参与持开放态度。通过经济上可行的模式,在CR护士的支持下提供量身定制的教育和锻炼内容,被认为是满足农村地区妇女需求和偏好的必要条件。这些研究结果为制定包容性和可持续的企业社会责任计划提供了重要见解,以满足农村地区妇女的独特需求。
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引用次数: 0
Systematic reviews of values and preferences: Methodological challenges, approaches and implications for clinical guideline development. 价值和偏好的系统评价:临床指南制定的方法学挑战、方法和意义。
IF 3.9 Pub Date : 2026-02-02 DOI: 10.1093/eurjcn/zvag036
Lemma N Bulto, Zachary Munn, Cindy Stern, Danielle Pollock, Timothy Hugh Barker

Systematic reviews of values and preferences are essential to ensure that healthcare decision-making and clinical practice guidelines reflect what truly matters to patients, caregivers, policymakers and other interest-holders. These reviews synthesise evidence on how people value different health outcomes and provide critical information about the trade-offs they are willing to make (e.g. the willingness to accept an intervention's side effects to gain a meaningful benefit for a more highly valued outcome). The importance of these reviews in developing trustworthy guidelines is evident, yet limited methodological guidance exists. The process of conducting these reviews presents unique methodological challenges. This paper addresses these challenges by providing a systematic, step-by-step guide for planning and conducting value and preference reviews. We detail key considerations for each stage, from formulating the review question to assessing the certainty of evidence and illustrate these methodological approaches with examples from published reviews to enhance practical understanding.

系统地审查价值观和偏好对于确保卫生保健决策和临床实践指南反映对患者、护理人员、政策制定者和其他利益相关者真正重要的东西至关重要。这些审查综合了人们如何重视不同健康结果的证据,并提供了有关人们愿意做出的权衡的关键信息(例如,为了获得更有价值的结果而接受干预措施的副作用的意愿)。这些审查在制定值得信赖的指导方针方面的重要性是显而易见的,但存在有限的方法指导。进行这些审查的过程在方法上提出了独特的挑战。本文通过为计划和执行价值和偏好审查提供系统的、逐步的指南来解决这些挑战。我们详细介绍了每个阶段的关键考虑因素,从制定综述问题到评估证据的确定性,并从已发表的综述中举例说明这些方法学方法,以增强实际理解。
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引用次数: 0
Positioning the front-door-score tool for NSTEMI in emergency departments. 在急诊科定位NSTEMI的前门评分工具。
IF 3.9 Pub Date : 2026-02-01 DOI: 10.1093/eurjcn/zvaf250
Evangeline Loh, Kuan Win Sen, Wilson Tam
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引用次数: 0
Self-Care for a Heart-Healthy Lifestyle scale in cardiovascular disease prevention: development and psychometric testing. 心血管疾病预防中的自我保健心脏健康生活方式量表:开发和心理测量测试。
IF 3.9 Pub Date : 2026-02-01 DOI: 10.1093/eurjcn/zvaf251
Jina Choo, Jihyun Moon, Songwhi Noh, Yura Shin

Aims: We aimed to develop the Self-Care for a Heart-Healthy Lifestyle (SC-HeartLife) scale among community-dwelling adults without a history of cardiovascular disease and evaluate its psychometric properties.

Methods and results: The 'SC-HeartLife' scale was developed in three phases-initial item pool generation, content and face validity, and psychometric testing-guided by the Middle-Range Theory of Self-Care of Chronic Illness. A total of 946 community-dwelling adults in South Korea were recruited through an online survey. From an initial 83 items, 43 were retained following content and face validity evaluations. Using two split random samples, exploratory factor analysis and the first confirmatory factor analysis (CFA) were performed with Subsample 1 (n = 473) to develop a seven-factor hierarchical model. The second CFA with Subsample 2 (n = 473) was then conducted for cross-validation. Structural validity was supported by a 38-item, seven-factor hierarchical model demonstrating good fit (CMIN/DF = 2.07, CFI = 0.91, TLI = 0.91, RMSEA = 0.05, SRMR = 0.06). The model comprises three scales: self-care maintenance (five factors), self-care monitoring (one factor), and self-care management (one factor). It was also evidenced by significant correlations of the 'SC-HeartLife' with health-promoting behaviours and health-related quality of life. Reliability was acceptable, with strong internal consistency (global reliability = 0.94) and test-retest stability (intraclass correlation coefficient = 0.89).

Conclusion: The 38-item 'SC-HeartLife' scale, on a 5-point Likert scale, is a valid and reliable tool. It is applicable across both clinical and research settings, supporting the identification of individuals and communities vulnerable to inadequate 'SC-HeartLife' and the evaluation of tailored interventions designed to promote self-care in the context of cardiovascular disease prevention.

目的:在无心血管疾病史的社区居民中编制心脏健康生活方式自我保健(SC-HeartLife)量表,并评估其心理测量学特性。方法与结果:《SC-HeartLife》量表以《慢性病自我护理中程理论》为指导,分为初始题库生成、内容效度和面效度、心理测量三个阶段进行编制。通过在线调查,共招募了946名居住在韩国社区的成年人。从最初的83个项目中,经过内容和表面效度评估,保留了43个。采用两个分裂随机样本,对Subsample 1 (n = 473)进行探索性因子分析和第一次验证性因子分析(CFA),建立七因素层次模型。然后对子样本2 (n = 473)进行第二次CFA交叉验证。结构效度采用38项7因素分层模型,拟合良好(CMIN/DF = 2.07, CFI = 0.91, TLI = 0.91, RMSEA = 0.05, SRMR = 0.06)。该模型包括三个量表:自我护理维持(五个因素)、自我护理监测(一个因素)和自我护理管理(一个因素)。“SC-HeartLife”与健康促进行为和健康相关生活质量的显著相关性也证明了这一点。信度可接受,具有较强的内部一致性(整体信度= 0.94)和重测稳定性(类内相关系数= 0.89)。结论:38项“SC-HeartLife”量表,5分李克特量表,是一个有效和可靠的工具。它适用于临床和研究环境,支持识别易受“SC-HeartLife”不足影响的个人和社区,并评估旨在促进心血管疾病预防背景下自我保健的量身定制干预措施。
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引用次数: 0
Efficacy and safety of operator-directed, nurse-administered propofol sedation in atrial fibrillation ablation. 操作员指导、护士给药异丙酚镇静在房颤消融中的有效性和安全性。
IF 3.9 Pub Date : 2026-02-01 DOI: 10.1093/eurjcn/zvaf252
Jinsun Park, Myung-Jin Cha, Min Soo Cho, Gi-Byoung Nam, Kee-Joon Choi, Jun Kim

Aims: Adequate sedation and analgesia are essential for catheter ablation of atrial fibrillation (AF) to ensure patient comfort and procedural safety. However, the availability of cardiac anaesthesiology is limited. This study evaluated the efficacy and safety of an operator-directed, nurse-administered (ODNA) sedation protocol using propofol and remifentanil during AF ablation.

Methods and results: In this prospective, single-centre observational cohort study, consecutive patients undergoing catheter ablation for AF from August 2023 to March 2024 were enrolled. Sedation-related adverse events and intra-procedural vital signs were recorded. Sedation depth was assessed using the Modified Observer's Alertness/Sedation (MOAA/S) scale, and patient satisfaction was evaluated using the Visual Analogue Scale (VAS). A total of 230 patients were included (mean age 61.9 years; 76.1% male). Of these, 7.4% had a body mass index of ≥30 kg/m2, and 4.3% had obstructive sleep apnoea. Paroxysmal AF accounted for 30.9%, and the mean procedure time was 174 min. The primary outcome-defined as unplanned sedation interruption, intubation, or continuous vasopressor requirement-occurred in 2.2% of patients. Intermittent hypotension (mean arterial pressure: <60 mmHg) occurred in 36.1% of patients, but no patient required continuous vasopressors. The mean MOAA/S score was 0.4 ± 0.4. Post-procedural surveys showed high satisfaction (mean VAS: 8.8) and low maximal pain (VAS: 0.9).

Conclusion: An ODNA protocol using propofol and remifentanil provides effective and safe sedation for AF ablation, with high patient satisfaction and minimal serious adverse events.

目的:充分的镇静和镇痛对于房颤(AF)导管消融至关重要,以确保患者舒适和手术安全。然而,心脏麻醉的可用性是有限的。本研究评估了在房颤消融期间使用异丙酚和瑞芬太尼的手术指导、护士给药(ODNA)镇静方案的有效性和安全性。方法和结果:在这项前瞻性单中心观察队列研究中,纳入了2023年8月至2024年3月期间接受房颤导管消融治疗的连续患者。记录镇静相关不良事件及术中生命体征。采用改进的观察者警觉/镇静(MOAA/S)量表评估镇静深度,采用视觉模拟量表(VAS)评估患者满意度。共纳入230例患者,平均年龄61.9岁,男性76.1%。其中,7.4%的人体重指数≥30 kg/m2, 4.3%的人患有阻塞性睡眠呼吸暂停。阵发性心房颤动占30.9%,平均手术时间为174 min。主要结局(定义为意外镇静中断、插管或持续的血管加压药物需求)发生在2.2%的患者中。结论:使用异丙酚和瑞芬太尼的ODNA方案为房颤消融提供了有效和安全的镇静,患者满意度高,严重不良事件最少。
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引用次数: 0
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European journal of cardiovascular nursing
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