Frontiers in oral health最新文献

Background: The successful implementation of the 2030 sustainable development Agenda in Africa requires active participation from all sectors, including the dental research sector. The aim of this study was to review dental research published by authors affiliated with institutions in African countries from 2016 to 2023, to map papers related to the sustainable development goals (SDGs), and to identify areas of emphasis and gaps in SDGs-related papers on oral health in Africa.

Methods: We conducted a bibliometric analysis of dental literature in Africa (2016-2023) using Scival for performance analysis and VOSviewer for science mapping. The papers addressing and not addressing the SDGs were compared regarding impact, authorship metrics and key phrases. We identified the topic clusters with the greatest number of papers. The key phrase co-occurrence networks and the authors and countries collaboration networks were mapped.

Results: There were 4,173 papers and 622 (14.9%) addressed the SDGs, especially SDG3. SDGs papers had greater impact and were more likely to be published in open access journals than non-SDGs papers. Egypt, Nigeria and South Africa had the greatest number of papers and citations. Four of the top ten authors were females. Most of the top ten journals were open access and only three were in quartile 1 (Q1) journals. Springer and Elsevier were the top publishers. The top research clusters addressed rehabilitative care including implants, endodontics, ceramics and zirconia. SDGs papers, however, addressed oral hygiene in caries prevention and to control systemic diseases. Collaboration networks were affected by geographic location and languages. Dental research in Africa is concentrated in three countries and mainly addresses rehabilitative care. SDGs papers had an impact above the global average and addressed prevention and non-communicable diseases.

Conclusions: There is minimal yet increasing contribution of African countries to the evidence on oral health and the SDGs. The focus is on a limited number of SDGs, and publications are from very few countries in Africa. There is a need to focus oral health-related SDGs research on addressing local problems.

Aim: The brief report aims to evaluate masticatory performance and components of chewing behavior in people with anorexia nervosa and compare it with a reference group of individuals with no history of eating disorders.

Material and methods: Eighteen women participated in the study: nine with anorexia nervosa (age 20.2 ± 5.9) and nine as controls in a reference group without anorexia nervosa (age 23.6 ± 0.9). Masticatory performance was assessed with a food comminution test. The participants also ate (chewed and swallowed) a second test food while their jaw movements were recorded to evaluate their chewing behavior. The number of comminuted pieces during the food comminution test, chewing cycles, chewing duration, and components like occlusal, and jaw opening/closing duration, were evaluated.

Results: In comparison to the reference group the anorexia nervosa patients performed poorly in the food comminution test (P = 0.007), and also chewed the test food significantly longer (P = 0.004) and with significantly more chewing cycles (P = 0.014). The results also showed a significantly longer jaw-closing duration in the anorexia nervosa group compared to the reference group (P = 0.021). However, there were no significant differences in either the jaw opening or the occlusal duration between the two groups.

Conclusion: Overall, the results of the study indicate that the anorexia nervosa group shows signs of poor masticatory performance and altered chewing behavior compared to the reference group of individuals with no history of eating disorders.

This study explored the knowledge, attitude, and practice towards silver diamine fluoride (SDF) therapy among dentists in Hong Kong. The quantitative component was an online closed-ended questionnaire survey through the Society of Preventive Dentistry of Hong Kong. The qualitative component involved individual in-depth interviews with selected dentists. Descriptive analysis was performed on the quantitative data, whereas thematic analysis was performed on the qualitative data. The quantitative study invited 173 dentists, and 86 completed the questionnaire survey (86/173; 50%). All respondents were familiar with SDF and 73 (73/86; 85%) used SDF. They agreed that SDF therapy was simple (84/86; 98%), non-invasive (84/86; 98%), timesaving (82/86; 96%), effective (81/86; 94%), and painless (79/86; 92%). However, they expressed concerns about SDF's unaesthetic staining (81/86; 94%) and used it for primary teeth (77/86; 89%). The qualitative study conducted 12 individual interviews. Dentists asserted that SDF therapy is an evidence-based practice for arresting caries, including root caries. They acknowledged SDF therapy is straightforward and cost-effective. It is particularly useful for children or people with disabilities and can be used in community service. They considered the application skills, close monitoring and maintaining good oral hygiene to be vital for the success of SDF therapy. However, they noted that black staining of the carious lesions could cause patient dissatisfaction. They suggested that a guideline is warranted for SDF use. Hong Kong dentists are aware of the indications, merits and limitations of SDF therapy. They use SDF therapy for caries control, especially for children, elderly and those with disabilities, and consider it cost-effective for community dental care.

Objectives: This systematic review aimed to assess the effectiveness of submucosal tramadol injections in post-operative pain management following third molar surgical extraction.

Materials and methods: Databases, such as PubMed, Scopus, ScienceDirect, and Cochrane Library, were systematically searched using relevant keywords. Randomized clinical trials that met the inclusion criteria were assessed to determine the effectiveness of tramadol in managing acute post-operative pain following third molar surgery.

Results: In total, seven studies with participants of 18 and over following randomized placebo-controlled trials were considered for the analysis. A submucosal injection of 2 ml (50-100 mg) of tramadol adjacent to the impacted mandibular third molar effectively controlled pain for up to 6-24 h following surgery. Non-serious adverse events, such as nausea, vomiting, and headache, were reported in two studies. Meta-analysis (subgroup analysis) revealed heterogeneity among the studies, demonstrating variability in the results across the included studies. In addition, tramadol demonstrated a significant decrease in post-operative pain.

Conclusion: Submucosal tramadol is an efficient, safe, and dependable method for reducing post-operative acute pain, particularly in the first 6 h following impacted third molar surgery. However, due to the observed heterogeneity in the research, there is need for cautious interpretation of the findings and potential limitations in the evidence base. To enhance the quality of evidence on this topic, we strongly recommend conducting new RCTs using established methodologies.

Clinical relevance: Post operative pain following third molar surgeries is one of the common complications. Submucosal tramadol injections were found to be successful in reducing post extraction pain as well as other morbidities.

Objectives: The purpose of the study was to assess the impact of a pretherapeutic Multidisciplinary Tumor Board (MTB) presentation on the prognosis and treatment outcomes in patients with primary oral cavity carcinoma.

Materials and methods: This single-center study included 630 patients diagnosed with oral cavity carcinoma treated between 2010 and 2020. The study cohort was divided in a group with and without pretherapeutic MTB presentation. Data on patient demographics, tumor characteristics, treatment and the time to treatment initiation (TTI) were collected retrospectively.

Results: Primary findings revealed no significant difference in 3-year survival rate (3-YSR) and 3-year disease-free survival rate (3-YDFSR) for the non-MTB and MTB group. The 3-YSR was 73.1% in the non-MTB group and 67.1% in the MTB group (p = 0.112). The 3-YDFSR was 73.8% in the non-MTB group and 76.5% in the MTB group (p = 0.447). Estimated mean 5-year survival (5-YS) and 5-year disease-free survival in (5-YDFS) did not differ significantly between both groups, across the UICC stages I-IV, as well as for the entire cohort. The TTI was significantly longer in the MTB group (33.5 days, CI: 31.3;35.7) compared to the non-MTB group (20.1 days, CI: 17.9;22.4, p < 0.001). The MTB group adhered more frequently to the national guidelines (68% vs. 79.6%, p < 0.01).

Conclusion: The results demonstrate both positive and negative side effects of the MTB presentation in patients with oral cavity cancer. Further multicenter studies will be required to assess the impact of TTI and adherence to guidelines on the survival of oral cavity cancer patients.

Objectives: To evaluate the possible changes of the oral microbiome during myelosuppressive chemotherapy (CT) and to investigate the potential relationship between the oral microbiome, the presence of oral mucositis (OM) and febrile neutropenia (FN).

Methods: A prospective, longitudinal, observational study was conducted in patients receiving myelosuppressive CT for a solid tumor or lymphoma. Oral rinsing samples were retrieved before, during and after the start of CT, but also when OM or FN was present. The samples were analyzed using 16S rRNA gene amplicon sequencing and statistical analysis was performed using alpha (Shannon) and beta (PERMANOVA) diversity analyses. Furthermore, differential abundances were analyzed using ALDEx2v1.32.0. Differences between groups were calculated using the Mann Whitney U-test, Kruskal-Wallis test and Wilcoxon Signed Rank using R.

Results: Forty-six patients, with a mean follow up of 114 days, were included for analysis and a total of 138 oral rinsing samples were available in the CLR-transformed data for PERMANOVA and 137 samples-for alpha diversity calculation. Significant changes in alpha diversity were seen when OM or FN was present. Moreover, significant changes were seen in beta diversity during the course of the CT treatment and when OM was present. Genera showing substantial changes in relative abundance were Streptococcus during the course of CT treatment and Prevotella, Fusobacterium, Selenomonas, Actinomyces and Leptotrichia when OM was present.

Conclusion: Changes in the oral microbiome were observed during the CT-regimen and when OM was present. Furthermore, changes of the oral microbiota during FN episodes were observed; however, larger studies should be performed to substantiate our results.

Background: COVID-19 is a respiratory disease, and its symptoms may be affected by the upper airways of adolescents.

Objective: To investigate the effect of parameters of adolescents' upper airways on COVID-19 symptom severity.

Methods: This retrospective study was performed from January to March 2022 at the Hospital of Stomatology, Xi'an Jiaotong University, Xi'an, China. The inclusion criteria were patients who started orthodontic treatment for the first time, who experienced initial onset of laboratory-confirmed COVID-19, and who received two intramuscular doses of the SARS-CoV-2 vaccine. Participants' COVID-19 symptom severity was recorded by a questionnaire including seven different dimensions. The three-dimensional parameters of the upper airway were obtained by cone beam computed tomography (CBCT) and measured by Dolphin Imaging software by blinded orthodontic investigators. The correlation between COVID-19 symptom severity and three-dimensional upper airway parameters was analyzed.

Results: 64 males (46.4%) and 74 females (53.6%) were included in the study, with the median age of 9.5 years. The severity score of dimension 3 (headache, muscle pain, fatigue, shortness of breath, diarrhea and smell affects) showed a linear relationship with age. Spearman's rank correlation showed that the severity score of dimension 1 (nasal symptoms) was negatively correlated with nasal volume (r = -0.325). The severity score of dimension 6 was negatively correlated with the height of the nasopharynx (r = -0.325) and positively correlated with the horizontal-to-vertical ratio of the oropharynx (r = 0.385).

Conclusions and relevance: The COVID-19 symptom severity was aggravated with the increase of age. Nasal and throat pain and dry mouth was negatively correlated with nasal volume and nasopharyngeal height. The COVID-19 symptom severity among individuals is relavant to age and upper airway.

Background: Anticoagulants, renowned for their role in preventing blood clot formation, have captivated researchers' attention for the exploitation of their potential to inhibit cancer in pre-clinical models.

Objectives: To undertake a systematic review and meta-analysis of the effects of anticoagulants in murine cancer research models. Further, to present a reference tool for anticoagulant therapeutic modalities relating to future animal pre-clinical models of cancer and their translation into the clinic.

Methods: Four databases were utilized including Medline (Ovid), Embase (Ovid), Web of science, and Scopus databases. We included studies relating to any cancer conducted in murine models that assessed the effect of traditional anticoagulants (heparin and its derivatives and warfarin) and newer oral anticoagulants on cancer.

Results: A total of 6,158 articles were identified in an initial multi-database search. A total of 157 records were finally included for data extraction. Studies on heparin species and warfarin demonstrated statistically significant results in favour of tumour growth and metastasis inhibition.

Conclusion: Our findings constitute a valuable reference guide for the application of anticoagulants in cancer research and explore the promising utilization of non-anticoagulants heparin in preclinical cancer research.

Systematic review registration: PROSPERO [CRD42024555603].

Introduction: Pediatric Obstructive Sleep Apnea (OSA) is a common sleep-related breathing disorder often linked to distinct craniofacial features and malocclusions. While orthodontic treatments, particularly maxillary expansion and mandibular advancement, have been suggested for managing this condition, the results remain controversial and are based on low-quality evidence. This paper aims to summarize the ongoing debates on this topic by reviewing relevant literature and highlighting the role of the orthodontist in diagnosing and managing OSA in daily clinical practice.

Discussion and conclusions: According to the present review, there is insufficient evidence to either confirm or deny the effectiveness of oral appliances for treating pediatric OSA due to significant methodological limitations, such as small sample sizes, inadequate control groups, short study durations, and a lack of long-term follow-up. Additionally, this condition cannot be diagnosed solely based on craniofacial morphology, but an interdisciplinary evaluation is strictly required. In addition, orthopedic treatment may be considered only as an adjunct therapy for children with craniofacial anomalies increasing the risk for OSA, and the combination of multiple therapeutic approaches may be necessary to achieve effective treatment outcomes.