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Positive effects of systemic sodium benzoate and olanzapine treatment on activities of daily life, spatial learning and working memory in ketamine-induced rat model of schizophrenia. 全身苯甲酸钠和奥氮平治疗对氯胺酮诱导的精神分裂症大鼠日常生活活动、空间学习和工作记忆的积极影响。
Pub Date : 2019-04-15 eCollection Date: 2019-01-01
Ghada S Mahmoud, Sally A Sayed, Shehabeldin N Abdelmawla, Mohamed A Amer

Background: Sodium Benzoate (SB) significantly improved positive, negative, and cognitive symptoms as add on treatment in schizophrenia. Olanzapine (Ola), the most effective atypical antipsychotic drug, has been linked to hepatic steatosis, acute kidney injury, reproductive side effects and poor effect on negative symptoms in some patients.

Goals: is to compare the efficacy and check the safety of long-term monotherapy with SB 0.01 mg/Kg versus Ola on male cognitive, memory, hepatic, renal and testicular functions in rat model of schizophrenia.

Methods: 48 young adult male rats were divided into 6 groups; C: control; O: received Ola; SB: received SB; K: received single IP ketamine (Ket) injection; K+O: received Ola and Ket and K+SB: received SB and Ket. Ola and SB given orally for 3 or 10 weeks for behavioral or serological studies respectively. We measured activities of daily life (ADL), spatial learning and memory in radial arm water maze (RAWM), serum parameters of hepatic, renal and testicular functions.

Results: Both Ola and SB significantly improved hoarding and burrowing, caused significant decrease in time to reach target (TRT), working memory errors (WME) in K+O and K+SB groups compared to K group. Ola caused significant increase in ALT, AST and creatinine and decrease in serum LH, testosterone compared to controls. SB caused significant rise in serum LH, ALT, AST and decrease in protein and albumin compared to both C and O groups.

Conclusion: Both Ola and SB improved ADL, cognitive and memory functions. Although SB saved testicular and renal functions, it worsened liver function compared to Ola.

背景:苯甲酸钠(SB)作为精神分裂症的辅助治疗,显著改善了阳性、阴性和认知症状。奥氮平(Ola)是最有效的非典型抗精神病药物,与一些患者的肝脂肪变性、急性肾损伤、生殖副作用和对阴性症状的不良影响有关。目的:比较SB 0.01 mg/Kg与Ola对精神分裂症大鼠模型雄性认知、记忆、肝、肾和睾丸功能的长期单一疗法的疗效和安全性。方法:将48只青年成年雄性大鼠分为6组;C: 控制;O: 收到Ola;SB:收到SB;K: 接受单次IP氯胺酮(Ket)注射;K+O:接受Ola和Ket,K+SB:接受SB和Ket。Ola和SB分别口服3周或10周进行行为学或血清学研究。我们测量了日常生活能力(ADL)、桡臂水迷宫(RAWM)中的空间学习和记忆,以及肝、肾和睾丸功能的血清参数。结果:与K组相比,Ola和SB显著改善了K+O和K+SB组的囤积和挖洞,导致达到目标的时间(TRT)和工作记忆错误(WME)显著减少。与对照组相比,Ola导致ALT、AST和肌酐显著升高,血清LH和睾酮降低。与C组和O组相比,SB导致血清LH、ALT、AST显著升高,蛋白质和白蛋白降低。结论:Ola和SB均能改善ADL、认知和记忆功能。尽管SB挽救了睾丸和肾功能,但与Ola相比,它使肝功能恶化。
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引用次数: 0
The effect of lunasin from Indonesian soybean extract on histopatologic examination and cox-2 expression in dextran sodium sulfate-induced mice colon. 印尼大豆提取物lunasin对右旋糖酐硫酸钠诱导的小鼠结肠组织病理学检查和cox-2表达的影响。
Pub Date : 2018-12-25 eCollection Date: 2018-01-01
Kusmardi Kusmardi, Nessa Nessa, Ari Estuningtyas, Aryo Tedjo

Inflammatory bowel disease (IBD) is a condition describing chronic gastrointestinal inflammation. Chronic inflammation in colon can develop into colon cancer. Lunasin has been known to inhibit inflammatory reactions induced by lipopolysaccharide in vitro. The effect of lunasin to inhibit inflammation in vivo is not widely known. In this study, we analyzed the effect of lunasin from soybean to decrease the risk of inflammation by analyzing histopathologic feature and the expression of COX-2. 30 mice are divided into 6 groups. Normal group was not induced by dextran sodium sulfate (DSS). The other groups were induced by 2% DSS through drinking water for 9 days. After 9 days, negative control group did not receive any treatment. The other groups received treatment given lunasin dose 20 mg/kg body weight (BW) and 40 mg/kg BW, commercial lunasin and positive control given aspirin. Treatment was performed for 5 weeks. Inflammatory colon histopathologic examination and immunohistochemical score of COX-2 proteins were analyzed using statistical tests. Lunasin dose 20 mg/kg BW and 40 mg/kg BW were able to significantly reduce inflammation (P<0.05) performed by histopathologic feature with an average score of 2.52 and 2.16 COX-2 expression decreased significantly (P<0.05) with an average score of 43.674 and 33.349. Lunasin dose 20 mg/kg BW and 40 mg/kg BW were able to inhibit inflammation and decrease the expression of COX-2 in colon induced by DSS.

炎症性肠病(IBD)是一种描述慢性胃肠道炎症的疾病。结肠慢性炎症可发展为结肠癌。众所周知,Lunasin可以抑制脂多糖在体外诱导的炎症反应。lunasin在体内抑制炎症的作用还不广为人知。在本研究中,我们通过分析组织病理学特征和COX-2的表达,分析了大豆lunasin降低炎症风险的作用。将30只小鼠分为6组。正常组未经右旋糖酐硫酸钠(DSS)诱导。其他组用2%DSS通过饮水诱导9天。9天后,阴性对照组未接受任何治疗。其他组接受lunasin剂量20 mg/kg体重(BW)和40 mg/kg体重的治疗,商业lunasin和阳性对照给予阿司匹林。治疗5周。应用统计学检验分析炎症性结肠组织病理学检查和COX-2蛋白的免疫组织化学评分。Lunasin剂量20mg/kg BW和40mg/kg BW能显著减轻炎症反应(P
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引用次数: 0
New insights and new hope for pulmonary arterial hypertension: natriuretic peptides clearance receptor as a novel therapeutic target for a complex disease. 肺动脉高压的新见解和新希望:利钠肽清除受体作为一种复杂疾病的新治疗靶点。
Pub Date : 2017-03-21 DOI: 10.1016/S0735-1097(17)35291-9
E. Egom, Tiam Feridooni, R. Pharithi, B. Khan, Haaris A. Shiwani, V. Maher, Yassine El Hiani, R. Rose, K. Pasumarthi, Hilaire A Ribama
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引用次数: 14
Modulatory influence of Parkia biglobosa protein isolate on testosterone and biomarkers of oxidative stress in brain and testes of streptozotocin-induced diabetic male rats. 大叶朴树蛋白分离物对链脲佐菌素诱导的糖尿病雄性大鼠大脑和睾丸中睾酮和氧化应激生物标志物的调节作用
Pub Date : 2016-09-30 eCollection Date: 2016-01-01
Bolajoko Idiat Ogunyinka, Babatunji Emmanuel Oyinloye, Foluso Oluwagbemiga Osunsanmi, Andrew Rowland Opoku, Abidemi Paul Kappo

Parkia biglobosa seed an important household spice commonly consumed in Nigeria is believed to possess antioxidant activity that may exert modulatory effects in diabetes and diabetic complications. This study investigated the modulatory potential of Parkia biglobosa protein isolate (PBPi) on serum testosterone (sTT) level as well as its influence on biomarkers of oxidative stress in brain and testes of streptozotocin-induced diabetic male rats. Animals were made diabetic by single intraperitoneal administration of streptozotocin (STZ; 60 mg/kg body weight). PBPi (200 or 400 mg/kg body weight) was given orally by gavage or insulin (5 U/kg, i.p.) was administered daily to STZ-induced diabetic rats for 28 days. The results revealed a significant elevation in thiobarbituric acid reactive substances (TBARS) levels in the brain and testes of diabetic rats. This was closely associated with a concomitant reduction in levels of sTT and reduced testes weight, a noticeable decline in the glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) as well as total glutathione (Total GSH) level in the brain and testes of diabetic rats. Interestingly, treatment with PBPi efficiently prevented the alterations witnessed in the serum sTT and also ameliorated various alterations in the biomarkers of oxidative stress (TBARS, Total GSH, GST, SOD and CAT) in brain and testes of diabetic rats. These results provide evidence that PBPi could protect the brain and testicular tissues against oxidative stress induced by STZ, via modulation of serum testosterone concentration and also by enhancing antioxidant defence system in STZ-diabetic rats.

大叶朴树籽是尼日利亚人经常食用的一种重要家用香料,据信具有抗氧化活性,可对糖尿病和糖尿病并发症产生调节作用。本研究调查了大叶朴树分离蛋白(PBPi)对血清睾酮(sTT)水平的调节潜力,以及它对链脲佐菌素诱导的糖尿病雄性大鼠大脑和睾丸氧化应激生物标志物的影响。通过腹腔注射链脲佐菌素(STZ;60 毫克/千克体重)使动物患上糖尿病。给 STZ 诱导的糖尿病大鼠灌胃口服 PBPi(200 或 400 毫克/千克体重)或每天注射胰岛素(5 U/kg,静注),连续 28 天。结果显示,糖尿病大鼠脑部和睾丸中硫代巴比妥酸反应物质(TBARS)水平明显升高。与此同时,糖尿病大鼠大脑和睾丸中的 sTT 水平降低、睾丸重量减轻、谷胱甘肽-S-转移酶(GST)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)以及总谷胱甘肽(Total GSH)水平明显下降。有趣的是,使用 PBPi 能有效防止血清 sTT 的变化,还能改善糖尿病大鼠大脑和睾丸中氧化应激生物标志物(TBARS、总 GSH、GST、SOD 和 CAT)的各种变化。这些结果证明,PBPi 可通过调节血清睾酮浓度和增强 STZ 糖尿病大鼠的抗氧化防御系统,保护大脑和睾丸组织免受 STZ 诱导的氧化应激。
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引用次数: 0
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International journal of physiology, pathophysiology and pharmacology
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