According to World Health Organisation data, cancer is one of the most influential diseases that goes head to head with heart diseases in the ranking of causes of death, causing approximately 10 million deaths annually and accounting for 20% of all deaths. Lung cancer is a leading cause of cancer-related deaths globally for both men and women. In some pre-clinical studies in cancer cell line in vitro experiments, some results have been obtained that Aloe Vera Extract (AVE) obtained from Aloe vera plant and Cannabindiol (CBD) obtained from Cannabis sativa may have anticancer effect against cancer, but more analysis is required for the reliability of these results. In this study, the cytotoxic and apoptotic effects of AVE and CBD in human lung cancer (A549 and BEAS) cells were studied in a multifaceted manner. Diagnosis of lung cancer disease is approximately 15% in the early stage and 85% in the late stage or metastatic stage. Therefore, despite the use of targeted drugs today, the 5-year survival rate of patients can only be 5-10%. In this study, the cytotoxic and apoptotic effects of AVE and CBD on human lung cancer cells A549 and healthy normal BEAS-2B cells were studied in a versatile and comparative manner. Cytotoxic effect of AVE and CBD was evaluated by xCELLigence RTCA System and AnnexinV-FITC/PI Apoptosis Assay by Flow Cytometry. In the current investigation, we discovered that AVE and CBD might incite a relative higher ratio of cell death in lung cancer cells (A549) than in non-cancer human epithelial lung cell line BEAS-2B, which may be achieved through regulating mitochondrial metabolism. In summary, our research is under Patent submission and shows that CBD and AVE have the potential to develop into a potent new anti-lung cancer drug.
{"title":"Cannabidiol and Aloe vera Extract to Human Cells: Bioactive Molecules as a Promising Anti-Lung Cancer Drug","authors":"","doi":"10.47485/2767-5416.1039","DOIUrl":"https://doi.org/10.47485/2767-5416.1039","url":null,"abstract":"According to World Health Organisation data, cancer is one of the most influential diseases that goes head to head with heart diseases in the ranking of causes of death, causing approximately 10 million deaths annually and accounting for 20% of all deaths. Lung cancer is a leading cause of cancer-related deaths globally for both men and women. In some pre-clinical studies in cancer cell line in vitro experiments, some results have been obtained that Aloe Vera Extract (AVE) obtained from Aloe vera plant and Cannabindiol (CBD) obtained from Cannabis sativa may have anticancer effect against cancer, but more analysis is required for the reliability of these results. In this study, the cytotoxic and apoptotic effects of AVE and CBD in human lung cancer (A549 and BEAS) cells were studied in a multifaceted manner. Diagnosis of lung cancer disease is approximately 15% in the early stage and 85% in the late stage or metastatic stage. Therefore, despite the use of targeted drugs today, the 5-year survival rate of patients can only be 5-10%. In this study, the cytotoxic and apoptotic effects of AVE and CBD on human lung cancer cells A549 and healthy normal BEAS-2B cells were studied in a versatile and comparative manner. Cytotoxic effect of AVE and CBD was evaluated by xCELLigence RTCA System and AnnexinV-FITC/PI Apoptosis Assay by Flow Cytometry. In the current investigation, we discovered that AVE and CBD might incite a relative higher ratio of cell death in lung cancer cells (A549) than in non-cancer human epithelial lung cell line BEAS-2B, which may be achieved through regulating mitochondrial metabolism. In summary, our research is under Patent submission and shows that CBD and AVE have the potential to develop into a potent new anti-lung cancer drug.","PeriodicalId":94090,"journal":{"name":"Journal of medical clinical case reports","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135348733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
West Nile virus (WNV) is the leading cause of mosquito-borne disease in the continental United States. It is most commonly spread to people by the bite of an infected mosquito. Cases of WNV occur during mosquito season, which starts in the summer and continues through fall. There are no vaccines to prevent or medications to treat WNV in people. Fortunately, most people infected with WNV do not feel sick. About 20% of people who are infected develop a fever and other symptoms. About 1% infected people develop a serious, sometimes fatal, illness.
{"title":"West Nile Virus Infection – Encephalitis – Lower Respiratory Tract Infection – Respiratory failure type II-CASE REPORT","authors":"","doi":"10.47485/2767-5416.1038","DOIUrl":"https://doi.org/10.47485/2767-5416.1038","url":null,"abstract":"West Nile virus (WNV) is the leading cause of mosquito-borne disease in the continental United States. It is most commonly spread to people by the bite of an infected mosquito. Cases of WNV occur during mosquito season, which starts in the summer and continues through fall. There are no vaccines to prevent or medications to treat WNV in people. Fortunately, most people infected with WNV do not feel sick. About 20% of people who are infected develop a fever and other symptoms. About 1% infected people develop a serious, sometimes fatal, illness.","PeriodicalId":94090,"journal":{"name":"Journal of medical clinical case reports","volume":"152 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134931255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction Bleeding during percutaneous nephrolithotomy (PCNL) surgery is a significant concern and a common surgical complication. This study aimed to identify factors associated with excessive bleeding in patients during or after PCNL surgery. Methods In this retrospective study, a total of 357 patients who underwent PCNL surgery were evaluated within the period from October 2019 to October 2020. Patient-related factors, kidney stones, and surgical details were recorded. The median drop in hemoglobin after PCNL was 5.1, and values exceeding this were considered as excessive bleeding. Results In this study, only 51.2% of patients experienced decreased hemoglobin levels. The average stone size in patients with and without reduced hemoglobin levels was 2.48 cm and 2.41 cm, respectively. The mean duration of surgery in patients with and without a decrease in hemoglobin levels was 58.69 minutes and 55.30 minutes, respectively. The mean access time for patients with and without reduced hemoglobin levels was 68.62 seconds and 65.71 seconds, respectively. The mean exposure time to radiation for patients with and without a decrease in hemoglobin levels was 74.11 seconds and 68.80 seconds, respectively. In this study, no significant relationship was found between patient gender, stone size, duration of surgery, access time, previous surgical history, and a decrease in hemoglobin levels. However, a significant association was observed between the access site and decreased hemoglobin levels. Conclusion Despite concerns regarding intraoperative complications, PCNL is an effective and safe treatment modality for patients with kidney stones, irrespective of their clinical treatment history. Furthermore, the advantages of this minimally invasive approach can be applied to all patients.
{"title":"Investigation of Factors Associated with Excessive Bleeding in Patients Undergoing Percutaneous Nephrolithotomy Surgery at Imam Khomeini Hospital in Urmia City during the period from October 2019 to October 2020","authors":"","doi":"10.47485/2767-5416.1036","DOIUrl":"https://doi.org/10.47485/2767-5416.1036","url":null,"abstract":"Introduction Bleeding during percutaneous nephrolithotomy (PCNL) surgery is a significant concern and a common surgical complication. This study aimed to identify factors associated with excessive bleeding in patients during or after PCNL surgery. Methods In this retrospective study, a total of 357 patients who underwent PCNL surgery were evaluated within the period from October 2019 to October 2020. Patient-related factors, kidney stones, and surgical details were recorded. The median drop in hemoglobin after PCNL was 5.1, and values exceeding this were considered as excessive bleeding. Results In this study, only 51.2% of patients experienced decreased hemoglobin levels. The average stone size in patients with and without reduced hemoglobin levels was 2.48 cm and 2.41 cm, respectively. The mean duration of surgery in patients with and without a decrease in hemoglobin levels was 58.69 minutes and 55.30 minutes, respectively. The mean access time for patients with and without reduced hemoglobin levels was 68.62 seconds and 65.71 seconds, respectively. The mean exposure time to radiation for patients with and without a decrease in hemoglobin levels was 74.11 seconds and 68.80 seconds, respectively. In this study, no significant relationship was found between patient gender, stone size, duration of surgery, access time, previous surgical history, and a decrease in hemoglobin levels. However, a significant association was observed between the access site and decreased hemoglobin levels. Conclusion Despite concerns regarding intraoperative complications, PCNL is an effective and safe treatment modality for patients with kidney stones, irrespective of their clinical treatment history. Furthermore, the advantages of this minimally invasive approach can be applied to all patients.","PeriodicalId":94090,"journal":{"name":"Journal of medical clinical case reports","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135999031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction More associated symptoms have been reported with the increasing number of COVID-19 cases worldwide. However, the precise impact of the disease on the urinary system and related urinary symptoms has yet to be adequately evaluated. The present study aims to investigate the subsequent lower urinary tract symptoms in patients attending Tadbir Clinic in Urmia City who have a history of infection due to COVID-19 within less than two months. Methods This study evaluated patients referred to the Urology Department of Tadbir Clinic in Urmia City between December 2020 and July 2021 who had tested positive for COVID-19 by RT-PCR within the past two months. The patient’s hospitalization history and the occurrence or exacerbation of urinary symptoms were recorded, and they completed the International Prostate Symptom Score (IPSS) questionnaire. Results This study included 150 patients with a mean age of 44.12 years, including 80 males and 70 females. None of the patients had severe urinary symptoms. 92.7% of the patients had mild urinary symptoms, and 7.3% had moderate urinary symptoms. The prevalence of moderate urinary symptoms was significantly higher in females than in males (P-value = 0.04). Individuals with moderate urinary symptoms had a higher mean age than those with mild urinary symptoms (P-value = 0.03). Among patients with or without a history of hospitalization, including those with a history of intensive care unit (ICU) admission, there was no significant difference in the severity of urinary symptoms (P-value = 0.5). Nocturia was the most common symptom reported by patients after the COVID-19 infection. Conclusion The severity of urinary symptoms was higher in females than males, and individuals with more severe urinary symptoms were generally older. There was no significant difference in terms of hospitalization history or the occurrence of severe urinary symptoms. Nocturia and frequency were the most prevalent symptoms among the patients.
{"title":"An Investigation of Subsequent Lower Urinary Tract Symptoms in Patients With a History of Infection of COVID-19 at Tadbir Clinic in Urmia City During the Period From December 2020 to July 2021","authors":"","doi":"10.47485/2767-5416.1037","DOIUrl":"https://doi.org/10.47485/2767-5416.1037","url":null,"abstract":"Introduction More associated symptoms have been reported with the increasing number of COVID-19 cases worldwide. However, the precise impact of the disease on the urinary system and related urinary symptoms has yet to be adequately evaluated. The present study aims to investigate the subsequent lower urinary tract symptoms in patients attending Tadbir Clinic in Urmia City who have a history of infection due to COVID-19 within less than two months. Methods This study evaluated patients referred to the Urology Department of Tadbir Clinic in Urmia City between December 2020 and July 2021 who had tested positive for COVID-19 by RT-PCR within the past two months. The patient’s hospitalization history and the occurrence or exacerbation of urinary symptoms were recorded, and they completed the International Prostate Symptom Score (IPSS) questionnaire. Results This study included 150 patients with a mean age of 44.12 years, including 80 males and 70 females. None of the patients had severe urinary symptoms. 92.7% of the patients had mild urinary symptoms, and 7.3% had moderate urinary symptoms. The prevalence of moderate urinary symptoms was significantly higher in females than in males (P-value = 0.04). Individuals with moderate urinary symptoms had a higher mean age than those with mild urinary symptoms (P-value = 0.03). Among patients with or without a history of hospitalization, including those with a history of intensive care unit (ICU) admission, there was no significant difference in the severity of urinary symptoms (P-value = 0.5). Nocturia was the most common symptom reported by patients after the COVID-19 infection. Conclusion The severity of urinary symptoms was higher in females than males, and individuals with more severe urinary symptoms were generally older. There was no significant difference in terms of hospitalization history or the occurrence of severe urinary symptoms. Nocturia and frequency were the most prevalent symptoms among the patients.","PeriodicalId":94090,"journal":{"name":"Journal of medical clinical case reports","volume":"250 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135999030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction Chronic kidney failure is one of the most common diseases in the world. The prevalence and incidence of end-stage renal disease are increasing in developed and developing countries, bringing a tremendous financial burden to healthcare systems. Therefore, according to the above, this study aims to compare graft survival in kidney transplant recipients over 50 years old and under 50 years old in Imam Reza Hospital, Tabriz, Iran. Methods Following approval from the Regional Research Ethics Committee, a retrospective study was conducted on all patients admitted to Imam Reza Hospital in Tabriz in 2020 who underwent kidney transplantation. Results This study included 74 patients, of which 50 (67.6%) were male, and 24 (32.4%) were female. The mean age of the transplant recipients was 40.91 ± 14.20, with 47 (63.5%) being under 50 years of age and 27 (36.5%) aged 50 or above. Of these patients, 8 (10.8%) were deceased, and 66 (89.2%) were living cases. The left kidney was transplanted in 67 (90.5%) and the right kidney in 7 (9.5%). The mean age of the deceased patients (8 patients) was 53.37 ± 9.73, while the mean age of the living patients (66 patients) was 39.40 ± 13.96, resulting in a statistically significant difference (p < 0.01). Additionally, 6 (22.2%) of the patients aged 50 and above who underwent transplantation died, compared to 4.3% in the patients aged under 50 (2 patients); this was also statistically significant (p = 0.01). Conclusion The results of the study, which involved 74 patients, revealed that there was no significant difference in gender and side of the transplanted kidney between the two groups; however, age was found to be an important factor in patient survival.
{"title":"Comparison of Graft Survival in Kidney Transplant Recipients Over 50 Years and Under 50 Years in Tabriz Imam Reza Hospital","authors":"","doi":"10.47485/2767-5416.1034","DOIUrl":"https://doi.org/10.47485/2767-5416.1034","url":null,"abstract":"<span class=\"correspondence-author\">Introduction</span> Chronic kidney failure is one of the most common diseases in the world. The prevalence and incidence of end-stage renal disease are increasing in developed and developing countries, bringing a tremendous financial burden to healthcare systems. Therefore, according to the above, this study aims to compare graft survival in kidney transplant recipients over 50 years old and under 50 years old in Imam Reza Hospital, Tabriz, Iran. <span class=\"correspondence-author\">Methods</span> Following approval from the Regional Research Ethics Committee, a retrospective study was conducted on all patients admitted to Imam Reza Hospital in Tabriz in 2020 who underwent kidney transplantation. <span class=\"correspondence-author\">Results</span> This study included 74 patients, of which 50 (67.6%) were male, and 24 (32.4%) were female. The mean age of the transplant recipients was 40.91 ± 14.20, with 47 (63.5%) being under 50 years of age and 27 (36.5%) aged 50 or above. Of these patients, 8 (10.8%) were deceased, and 66 (89.2%) were living cases. The left kidney was transplanted in 67 (90.5%) and the right kidney in 7 (9.5%). The mean age of the deceased patients (8 patients) was 53.37 ± 9.73, while the mean age of the living patients (66 patients) was 39.40 ± 13.96, resulting in a statistically significant difference (p &lt; 0.01). Additionally, 6 (22.2%) of the patients aged 50 and above who underwent transplantation died, compared to 4.3% in the patients aged under 50 (2 patients); this was also statistically significant (p = 0.01). <span class=\"correspondence-author\">Conclusion</span> The results of the study, which involved 74 patients, revealed that there was no significant difference in gender and side of the transplanted kidney between the two groups; however, age was found to be an important factor in patient survival.","PeriodicalId":94090,"journal":{"name":"Journal of medical clinical case reports","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135089947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Much neurobiological and psychological knowledge about brain development and maturation in pregnancy and early childhood should be evaluated simultaneously, due to several underlying pathophysiological findings, because with proven clinical evidence, with time greater than twenty years, such as situations of Adverse Emotions in Childhood (ACE ), Post Traumatic Stress Disorder (PTSD), and recently the absence/deficit of oxytoninergic neurons responsible for family synchrony, cause a series of aberrant pathophysiological effects, with inflammatory, behavioral, cognitive, affective and social impairments [1].
{"title":"Stakekold ZXSY Brazil, Precision Medicine in Pediatric Clinic: Reward Deficiency Syndrome (RDS) Is Surprisingly Evolving and Found Everywhere: Is It “Blowing in the Wind”? Yes, but how Syndrome Z.","authors":"Antônio Dantas","doi":"10.47485/2767-5416.1033","DOIUrl":"https://doi.org/10.47485/2767-5416.1033","url":null,"abstract":"Much neurobiological and psychological knowledge about brain development and maturation in pregnancy and early childhood should be evaluated simultaneously, due to several underlying pathophysiological findings, because with proven clinical evidence, with time greater than twenty years, such as situations of Adverse Emotions in Childhood (ACE ), Post Traumatic Stress Disorder (PTSD), and recently the absence/deficit of oxytoninergic neurons responsible for family synchrony, cause a series of aberrant pathophysiological effects, with inflammatory, behavioral, cognitive, affective and social impairments [1].","PeriodicalId":94090,"journal":{"name":"Journal of medical clinical case reports","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77259775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
According to the American Society of Addiction Medicine (ASAM) and the World Health Organization (WHO), chemical dependence consists of a chronic and progressive disease. But without organized etiopathogenesis, we carried out in clinical practice, description of new specific neurological and clinical states, based on the brain physiology common to all human beings, which reorganized all Addiction Medicine, and the discovery of childhood, adult and elderly Z Syndromes, Syndrome Zoé, which are secondary to simultaneous neurological dysfunctions of human neuro-development, such as: 1) neurological deficit of familial asynchrony (DNAF), which generates in response 2) fear adaptation neuro behavior (amygdalian and limbic), 3) unconscious reproduction of familial asynchrony due to neurobiological psychodynamics, which generates the 4) hypodopaminergic neurological state or RDS described by Blum et al.
{"title":"Stakehold ZXSY: Disorder Deficit Familial Asynchrony and Syndrome Z","authors":"Antônio Dantas","doi":"10.47485/2767-5416.1032","DOIUrl":"https://doi.org/10.47485/2767-5416.1032","url":null,"abstract":"According to the American Society of Addiction Medicine (ASAM) and the World Health Organization (WHO), chemical dependence consists of a chronic and progressive disease. But without organized etiopathogenesis, we carried out in clinical practice, description of new specific neurological and clinical states, based on the brain physiology common to all human beings, which reorganized all Addiction Medicine, and the discovery of childhood, adult and elderly Z Syndromes, Syndrome Zoé, which are secondary to simultaneous neurological dysfunctions of human neuro-development, such as: 1) neurological deficit of familial asynchrony (DNAF), which generates in response 2) fear adaptation neuro behavior (amygdalian and limbic), 3) unconscious reproduction of familial asynchrony due to neurobiological psychodynamics, which generates the 4) hypodopaminergic neurological state or RDS described by Blum et al.","PeriodicalId":94090,"journal":{"name":"Journal of medical clinical case reports","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89134251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SARS-COV-2 explores every possible vulnerability in human body and uses it against the host. To treat this SARS-COV-2 induced COVID-19, we should consider and target the multiple factors this virus is targeting and identify the drugs for usage in a strategical way. This approach can save the patients from severe state of illness and damage associated with this disease. COVID-19 has been associated with hyper inflammation [101-109] and delayed humoral immune responses [110-115]. Most of the complications with COVID-19 patients have been associated with early hypoxia, ARDS, pneumonia [116-122] and Acute Lung Injury [123-127]. Viral load has been found to be associated directly with incidence of lung injury/epithelial injury or remote organ injury in COVID-19 patients [128-133].
{"title":"Yoghurt (LAB) as preventive method against COVID-19","authors":"","doi":"10.47485/2767-5416.1031","DOIUrl":"https://doi.org/10.47485/2767-5416.1031","url":null,"abstract":"SARS-COV-2 explores every possible vulnerability in human body and uses it against the host. To treat this SARS-COV-2 induced COVID-19, we should consider and target the multiple factors this virus is targeting and identify the drugs for usage in a strategical way. This approach can save the patients from severe state of illness and damage associated with this disease. COVID-19 has been associated with hyper inflammation [101-109] and delayed humoral immune responses [110-115]. Most of the complications with COVID-19 patients have been associated with early hypoxia, ARDS, pneumonia [116-122] and Acute Lung Injury [123-127]. Viral load has been found to be associated directly with incidence of lung injury/epithelial injury or remote organ injury in COVID-19 patients [128-133].","PeriodicalId":94090,"journal":{"name":"Journal of medical clinical case reports","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135846970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Pregnancy increases the risk of developing oral diseases and can lead to tooth loss. The aim of our study is to determine the influence of demographic factors, social status, attitudes, habits, and behaviors related to diet and oral hygiene, that may result in tooth loss in postpartum women. Methods: This cross-sectional survey was conducted in General Hospitals and Clinics for gynecology and obstetrics in the territory of the Autonomous Province of Vojvodina. Data on attitudes, habits and behaviors related to diet and oral hygiene that may result in tooth loss were obtained by surveying postpartum women on the day of discharge. Univariate and multivariate logistic analysis was used to study the relationship between associated factors and the tooth loss using CR and a 95% confidence interval. Values p <0.05. was considered statistically significant. Results: Our study included 4310 mothers with an average age of 27.31 years. Based on multivariate regression analysis, higher tooth loss was observed in: mothers over the age of 35 (CI=1.029-1.660; p=0.028), with low or no education (CI=1.388 -2.258; p<0.001), living alone (CI=1.126-3.728; p=0.019), who are of poor social status (CI=1.300-2,005; p<0.001), brush teeth for less than 2 minutes (CI=1.006-1.575; p=0.044),visit a dentist for dental treatment (CI=1.367-2.131; p<0.001), and consume cigarettes (CI=1.015-1.685; p=0.038). Conclusions: Our research has shown that sociodemographic factors, habits, attitudes and behaviors of postpartum women regarding oral hygiene and nutrition are directly related to tooth loss and can serve as a platform for adoption of special oral health promotion programs.
{"title":"Associated Factors for Tooth Loss in the Postpartum Women in Vojvodina","authors":"","doi":"10.47485/2767-5416.1030","DOIUrl":"https://doi.org/10.47485/2767-5416.1030","url":null,"abstract":"Background: Pregnancy increases the risk of developing oral diseases and can lead to tooth loss. The aim of our study is to determine the influence of demographic factors, social status, attitudes, habits, and behaviors related to diet and oral hygiene, that may result in tooth loss in postpartum women.\u0000\u0000Methods: This cross-sectional survey was conducted in General Hospitals and Clinics for gynecology and obstetrics in the territory of the Autonomous Province of Vojvodina. Data on attitudes, habits and behaviors related to diet and oral hygiene that may result in tooth loss were obtained by surveying postpartum women on the day of discharge. Univariate and multivariate logistic analysis was used to study the relationship between associated factors and the tooth loss using CR and a 95% confidence interval. Values p <0.05. was considered statistically significant.\u0000\u0000Results: Our study included 4310 mothers with an average age of 27.31 years. Based on multivariate regression analysis, higher tooth loss was observed in: mothers over the age of 35 (CI=1.029-1.660; p=0.028), with low or no education (CI=1.388 -2.258; p<0.001), living alone (CI=1.126-3.728; p=0.019), who are of poor social status (CI=1.300-2,005; p<0.001), brush teeth for less than 2 minutes (CI=1.006-1.575; p=0.044),visit a dentist for dental treatment (CI=1.367-2.131; p<0.001), and consume cigarettes (CI=1.015-1.685; p=0.038).\u0000\u0000Conclusions: Our research has shown that sociodemographic factors, habits, attitudes and behaviors of postpartum women regarding oral hygiene and nutrition are directly related to tooth loss and can serve as a platform for adoption of special oral health promotion programs.","PeriodicalId":94090,"journal":{"name":"Journal of medical clinical case reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90083726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01Epub Date: 2023-06-21DOI: 10.47485/2767-5416.1035
Marco Foreman, Devon Foster, Ivelina Kioutchoukova, Brandon Lucke-Wold
Orthobiologics are playing an increasingly large role in the clinical setting across multiple fields of surgery. Particularly, in the field of orthopedic surgery, the employment of platelet-rich plasma (PRP) therapy in total joint arthroscopy (TJA) has become popular for its prompted benefits of controlling pain, blood loss, and increased wound healing. PRP was originally used for thrombolytic conditions, however, the aforementioned potential benefits have led to its increased use across various fields of medicine including dermatology, neurosurgery, orthopedics, and sports medicine. Currently, there is a persisting gap in the literature surrounding the mechanism of action of PRP, as well as its true role in increasing positive patient outcomes in the context of TJA. Thus, this review aims to briefly highlight the physiological mechanisms underlining PRP therapy, evaluate recent preclinical and clinical data about its effects on TJA patient outcomes, and to describe its concomitant use in novel orthopedic-applications.
{"title":"The Role of Platelet-Rich Plasma Therapy in Joint Arthroplasty A Mini-Review.","authors":"Marco Foreman, Devon Foster, Ivelina Kioutchoukova, Brandon Lucke-Wold","doi":"10.47485/2767-5416.1035","DOIUrl":"10.47485/2767-5416.1035","url":null,"abstract":"<p><p>Orthobiologics are playing an increasingly large role in the clinical setting across multiple fields of surgery. Particularly, in the field of orthopedic surgery, the employment of platelet-rich plasma (PRP) therapy in total joint arthroscopy (TJA) has become popular for its prompted benefits of controlling pain, blood loss, and increased wound healing. PRP was originally used for thrombolytic conditions, however, the aforementioned potential benefits have led to its increased use across various fields of medicine including dermatology, neurosurgery, orthopedics, and sports medicine. Currently, there is a persisting gap in the literature surrounding the mechanism of action of PRP, as well as its true role in increasing positive patient outcomes in the context of TJA. Thus, this review aims to briefly highlight the physiological mechanisms underlining PRP therapy, evaluate recent preclinical and clinical data about its effects on TJA patient outcomes, and to describe its concomitant use in novel orthopedic-applications.</p>","PeriodicalId":94090,"journal":{"name":"Journal of medical clinical case reports","volume":"5 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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