首页 > 最新文献

Journal of neural engineering最新文献

英文 中文
Identifying neural correlates of balance impairment in traumatic brain injury using partial least squares correlation analysis. 利用偏最小二乘相关性分析确定脑外伤平衡障碍的神经相关性。
Pub Date : 2024-09-12 DOI: 10.1088/1741-2552/ad7320
Vikram Shenoy Handiru, Easter Selvan Suviseshamuthu, Soha Saleh, Haiyan Su, Guang Yue, Didier Allexandre

Objective.Balance impairment is one of the most debilitating consequences of traumatic brain injury (TBI). To study the neurophysiological underpinnings of balance impairment, the brain functional connectivity during perturbation tasks can provide new insights. To better characterize the association between the task-relevant functional connectivity and the degree of balance deficits in TBI, the analysis needs to be performed on the data stratified based on the balance impairment. However, such stratification is not straightforward, and it warrants a data-driven approach.Approach.We conducted a study to assess the balance control using a computerized posturography platform in 17 individuals with TBI and 15 age-matched healthy controls. We stratified the TBI participants into balance-impaired and non-impaired TBI usingk-means clustering of either center of pressure (COP) displacement during a balance perturbation task or Berg Balance Scale score as a functional outcome measure. We analyzed brain functional connectivity using the imaginary part of coherence across different cortical regions in various frequency bands. These connectivity features are then studied using the mean-centered partial least squares correlation analysis, which is a multivariate statistical framework with the advantage of handling more features than the number of samples, thus making it suitable for a small-sample study.Main results.Based on the nonparametric significance testing using permutation and bootstrap procedure, we noticed that the weakened theta-band connectivity strength in the following regions of interest significantly contributed to distinguishing balance impaired from non-impaired population, regardless of the type of stratification:left middle frontal gyrus, right paracentral lobule, precuneus, andbilateral middle occipital gyri. Significance.Identifying neural regions linked to balance impairment enhances our understanding of TBI-related balance dysfunction and could inform new treatment strategies. Future work will explore the impact of balance platform training on sensorimotor and visuomotor connectivity.

背景:平衡障碍是创伤性脑损伤(TBI)造成的最严重后果之一。为了研究平衡障碍的神经生理学基础,扰动任务中的大脑功能连接可以提供新的见解。为了更好地描述与任务相关的功能连接与 TBI 平衡障碍程度之间的关联,需要根据平衡障碍对数据进行分层分析。然而,这种分层并不简单,需要采用数据驱动的方法:我们进行了一项研究,使用计算机化的体位测量平台评估 17 名创伤性脑损伤患者和 15 名年龄匹配的健康对照者的平衡控制能力。我们使用在平衡扰动任务中压力中心(COP)位移或伯格平衡量表(BBS)评分作为功能结果测量的 k-means 聚类,将 TBI 参与者分为平衡受损和非受损 TBI 患者。我们使用不同频段不同皮质区域的相干性虚部分析了大脑功能连通性。然后使用均值中心偏最小二乘相关分析(MC-PLSC)对这些连接特征进行研究,该分析是一个多变量统计框架,其优点是处理的特征数量多于样本数量,因此适用于小样本研究:基于使用permutation和bootstrap程序进行的非参数显著性检验,我们注意到,无论分层类型如何,以下相关区域的θ波段连接强度对区分平衡受损和非受损人群有显著作用:左额叶中回、右侧旁中央小叶、楔前区和双侧枕叶中回 意义:确定与平衡障碍有关的神经区域有助于加深我们对创伤性脑损伤相关平衡功能障碍的了解,并为新的治疗策略提供依据。未来的工作将探索平衡平台训练对感觉运动和视觉运动连接的影响。
{"title":"Identifying neural correlates of balance impairment in traumatic brain injury using partial least squares correlation analysis.","authors":"Vikram Shenoy Handiru, Easter Selvan Suviseshamuthu, Soha Saleh, Haiyan Su, Guang Yue, Didier Allexandre","doi":"10.1088/1741-2552/ad7320","DOIUrl":"10.1088/1741-2552/ad7320","url":null,"abstract":"<p><p><i>Objective.</i>Balance impairment is one of the most debilitating consequences of traumatic brain injury (TBI). To study the neurophysiological underpinnings of balance impairment, the brain functional connectivity during perturbation tasks can provide new insights. To better characterize the association between the task-relevant functional connectivity and the degree of balance deficits in TBI, the analysis needs to be performed on the data stratified based on the balance impairment. However, such stratification is not straightforward, and it warrants a data-driven approach.<i>Approach.</i>We conducted a study to assess the balance control using a computerized posturography platform in 17 individuals with TBI and 15 age-matched healthy controls. We stratified the TBI participants into balance-impaired and non-impaired TBI using<i>k</i>-means clustering of either center of pressure (COP) displacement during a balance perturbation task or Berg Balance Scale score as a functional outcome measure. We analyzed brain functional connectivity using the imaginary part of coherence across different cortical regions in various frequency bands. These connectivity features are then studied using the mean-centered partial least squares correlation analysis, which is a multivariate statistical framework with the advantage of handling more features than the number of samples, thus making it suitable for a small-sample study.<i>Main results.</i>Based on the nonparametric significance testing using permutation and bootstrap procedure, we noticed that the weakened theta-band connectivity strength in the following regions of interest significantly contributed to distinguishing balance impaired from non-impaired population, regardless of the type of stratification:<i>left middle frontal gyrus, right paracentral lobule, precuneus</i>, and<i>bilateral middle occipital gyri. Significance.</i>Identifying neural regions linked to balance impairment enhances our understanding of TBI-related balance dysfunction and could inform new treatment strategies. Future work will explore the impact of balance platform training on sensorimotor and visuomotor connectivity.</p>","PeriodicalId":94096,"journal":{"name":"Journal of neural engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cryogel microcarriers loaded with glial cell line-derived neurotrophic factor enhance the engraftment of primary dopaminergic neurons in a rat model of Parkinson's disease. 在帕金森病大鼠模型中,负载胶质细胞系源性神经营养因子的冷冻凝胶微载体能增强原发性多巴胺能神经元的移植。
Pub Date : 2024-09-12 DOI: 10.1088/1741-2552/ad7761
Kaushik Narasimhan, Abrar Hakami, Giulia Comini, Tommy Patton, Ben Newland, Eilís Dowd

Objective.Cryogel microcarriers made of poly(ethylene glycol) diacrylate and 3-sulfopropyl acrylate have the potential to act as delivery vehicles for long-term retention of neurotrophic factors (NTFs) in the brain. In addition, they can potentially enhance stem cell-derived dopaminergic (DAergic) cell replacement strategies for Parkinson's disease (PD), by addressing the limitations of variable survival and poor differentiation of the transplanted precursors due to neurotrophic deprivation post-transplantation in the brain. In this context, to develop a proof-of-concept, the aim of this study was to determine the efficacy of glial cell line-derived NTF (GDNF)-loaded cryogel microcarriers by assessing their impact on the survival of, and reinnervation by, primary DAergic grafts after intra-striatal delivery in Parkinsonian rat brains.Approach.Rat embryonic day 14 ventral midbrain cells were transplanted into the 6-hydroxydopamine-lesioned striatum either alone, or with GDNF, or with unloaded cryogel microcarriers, or with GDNF-loaded cryogel microcarriers.Post-mortem, GDNF and tyrosine hydroxylase immunostaining were used to identify retention of the delivered GDNF within the implanted cryogel microcarriers, and to identify the transplanted DAergic neuronal cell bodies and fibres in the brains, respectively.Main results.We found an intact presence of GDNF-stained cryogel microcarriers in graft sites, indicating their ability for long-term retention of the delivered GDNF up to 4 weeks in the brain. This resulted in an enhanced survival (1.9-fold) of, and striatal reinnervation (density & volume) by, the grafted DAergic neurons, in addition to an enhanced sprouting of fibres within graft sites.Significance.This data provides an important proof-of-principle for the beneficial effects of neurotrophin-loaded cryogel microcarriers on engraftment of cells in the context of cell replacement therapy in PD. For clinical translation, further studies will be needed to assess the impact of cryogel microcarriers on the survival and differentiation of stem cell-derived DAergic precursors in Parkinsonian rat brains.

目的:由聚(乙二醇)二丙烯酸酯和丙烯酸 3-磺丙基酯制成的冷凝胶微载体有可能成为在大脑中长期保留神经营养因子的输送载体。此外,它们还能解决移植前体在大脑中因移植后神经营养被剥夺而导致的存活率不一和分化不良的局限性,从而有可能加强治疗帕金森病的干细胞衍生多巴胺能细胞替代策略。在此背景下,为了开发概念验证,本研究旨在通过评估GDNF负载的冷冻凝胶微载体对帕金森病大鼠脑内多巴胺能原始移植物的存活率和神经再支配的影响,确定其疗效:将胚胎第14天的大鼠腹侧中脑细胞移植到6-羟基多巴胺缺损的纹状体中,或单独移植,或与GDNF一起移植,或与无负载的冷冻凝胶微载体一起移植,或与负载GDNF的冷冻凝胶微载体一起移植。尸体解剖后,GDNF和酪氨酸羟化酶免疫染色分别用于鉴定植入的冷冻凝胶微载体中GDNF的保留情况,以及鉴定大脑中移植的多巴胺能神经细胞体和神经纤维:我们发现移植部位的GDNF染色冷冻凝胶微载体完好无损,这表明它们能够将输送的GDNF在大脑中长期保留4周。这使得移植的多巴胺能神经元存活率(1.9 倍)和纹状体再支配(密度和体积)均有所提高,此外,移植部位内的纤维萌发也有所增强:这一数据提供了一个重要的原理证明,即在帕金森病的细胞替代疗法中,神经营养素负载的冷冻凝胶微载体对细胞的移植具有有益影响。为实现临床转化,还需要进一步研究评估低温凝胶微载体对帕金森病大鼠脑内干细胞衍生多巴胺能前体的存活和分化的影响。
{"title":"Cryogel microcarriers loaded with glial cell line-derived neurotrophic factor enhance the engraftment of primary dopaminergic neurons in a rat model of Parkinson's disease.","authors":"Kaushik Narasimhan, Abrar Hakami, Giulia Comini, Tommy Patton, Ben Newland, Eilís Dowd","doi":"10.1088/1741-2552/ad7761","DOIUrl":"10.1088/1741-2552/ad7761","url":null,"abstract":"<p><p><i>Objective.</i>Cryogel microcarriers made of poly(ethylene glycol) diacrylate and 3-sulfopropyl acrylate have the potential to act as delivery vehicles for long-term retention of neurotrophic factors (NTFs) in the brain. In addition, they can potentially enhance stem cell-derived dopaminergic (DAergic) cell replacement strategies for Parkinson's disease (PD), by addressing the limitations of variable survival and poor differentiation of the transplanted precursors due to neurotrophic deprivation post-transplantation in the brain. In this context, to develop a proof-of-concept, the aim of this study was to determine the efficacy of glial cell line-derived NTF (GDNF)-loaded cryogel microcarriers by assessing their impact on the survival of, and reinnervation by, primary DAergic grafts after intra-striatal delivery in Parkinsonian rat brains.<i>Approach.</i>Rat embryonic day 14 ventral midbrain cells were transplanted into the 6-hydroxydopamine-lesioned striatum either alone, or with GDNF, or with unloaded cryogel microcarriers, or with GDNF-loaded cryogel microcarriers.<i>Post-mortem</i>, GDNF and tyrosine hydroxylase immunostaining were used to identify retention of the delivered GDNF within the implanted cryogel microcarriers, and to identify the transplanted DAergic neuronal cell bodies and fibres in the brains, respectively.<i>Main results.</i>We found an intact presence of GDNF-stained cryogel microcarriers in graft sites, indicating their ability for long-term retention of the delivered GDNF up to 4 weeks in the brain. This resulted in an enhanced survival (1.9-fold) of, and striatal reinnervation (density & volume) by, the grafted DAergic neurons, in addition to an enhanced sprouting of fibres within graft sites.<i>Significance.</i>This data provides an important proof-of-principle for the beneficial effects of neurotrophin-loaded cryogel microcarriers on engraftment of cells in the context of cell replacement therapy in PD. For clinical translation, further studies will be needed to assess the impact of cryogel microcarriers on the survival and differentiation of stem cell-derived DAergic precursors in Parkinsonian rat brains.</p>","PeriodicalId":94096,"journal":{"name":"Journal of neural engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving non-invasive trajectory decoding via neural correlates of continuous erroneous feedback processing. 通过连续错误反馈处理的神经相关性改进非侵入式轨迹解码
Pub Date : 2024-09-12 DOI: 10.1088/1741-2552/ad7762
Hannah S Pulferer, Kyriaki Kostoglou, Gernot R Müller-Putz

Objective. Over the last decades, error-related potentials (ErrPs) have repeatedly proven especially useful as corrective mechanisms in invasive and non-invasive brain-computer interfaces (BCIs). However, research in this context exclusively investigated the distinction of discrete events intocorrectorerroneousto the present day. Due to this predominant formulation as a binary classification problem, classical ErrP-based BCIs fail to monitor tasks demanding quantitative information on error severity rather than mere qualitative decisions on error occurrence. As a result, fine-tuned and natural feedback control based on continuously perceived deviations from an intended target remains beyond the capabilities of previously used BCI setups.Approach.To address this issue for future BCI designs, we investigated the feasibility of regressing rather than classifying error-related activity non-invasively from the brain.Main results.Using pre-recorded data from ten able-bodied participants in three sessions each and a multi-output convolutional neural network, we demonstrated the above-chance regression of ongoing target-feedback discrepancies from brain signals in a pseudo-online fashion. In a second step, we used this inferred information about the target deviation to correct the initially displayed feedback accordingly, reporting significant improvements in correlations between corrected feedback and target trajectories across feedback conditions.Significance.Our results indicate that continuous information on target-feedback discrepancies can be successfully regressed from cortical activity, paving the way to increasingly naturalistic, fine-tuned correction mechanisms for future BCI applications.

目的:在过去几十年中,错误相关电位(ErrPs)多次被证明是有创和无创脑机接口(BCIs)中特别有用的纠正机制。然而,迄今为止,这方面的研究都只研究如何将离散事件区分为正确或错误。由于这种二元分类问题的主要表述方式,基于 ErrP 的经典 BCI 无法监控需要错误严重性定量信息的任务,而不仅仅是错误发生的定性决策。因此,基于持续感知到的与预期目标的偏差而进行的微调和自然反馈控制仍然超出了之前使用的 BCI 设置的能力范围:方法:为解决未来 BCI 设计中的这一问题,我们研究了从大脑非侵入性回归而非分类错误相关活动的可行性:主要结果:通过使用预先录制的十名健全参与者的数据(每人三次)和一个多输出卷积神经网络,我们以一种伪在线方式证明了从大脑信号中回归当前目标反馈差异的可能性。第二步,我们利用这些推断出的目标偏差信息对最初显示的反馈进行了相应的修正,结果表明,在各种反馈条件下,修正后的反馈与目标轨迹之间的相关性有了显著提高:我们的研究结果表明,目标反馈差异的连续信息可以成功地从大脑皮层活动中回归出来,从而为未来 BCI 应用中越来越自然的微调校正机制铺平了道路。
{"title":"Improving non-invasive trajectory decoding via neural correlates of continuous erroneous feedback processing.","authors":"Hannah S Pulferer, Kyriaki Kostoglou, Gernot R Müller-Putz","doi":"10.1088/1741-2552/ad7762","DOIUrl":"10.1088/1741-2552/ad7762","url":null,"abstract":"<p><p><i>Objective</i>. Over the last decades, error-related potentials (ErrPs) have repeatedly proven especially useful as corrective mechanisms in invasive and non-invasive brain-computer interfaces (BCIs). However, research in this context exclusively investigated the distinction of discrete events into<i>correct</i>or<i>erroneous</i>to the present day. Due to this predominant formulation as a binary classification problem, classical ErrP-based BCIs fail to monitor tasks demanding quantitative information on error severity rather than mere qualitative decisions on error occurrence. As a result, fine-tuned and natural feedback control based on continuously perceived deviations from an intended target remains beyond the capabilities of previously used BCI setups.<i>Approach.</i>To address this issue for future BCI designs, we investigated the feasibility of regressing rather than classifying error-related activity non-invasively from the brain.<i>Main results.</i>Using pre-recorded data from ten able-bodied participants in three sessions each and a multi-output convolutional neural network, we demonstrated the above-chance regression of ongoing target-feedback discrepancies from brain signals in a pseudo-online fashion. In a second step, we used this inferred information about the target deviation to correct the initially displayed feedback accordingly, reporting significant improvements in correlations between corrected feedback and target trajectories across feedback conditions.<i>Significance.</i>Our results indicate that continuous information on target-feedback discrepancies can be successfully regressed from cortical activity, paving the way to increasingly naturalistic, fine-tuned correction mechanisms for future BCI applications.</p>","PeriodicalId":94096,"journal":{"name":"Journal of neural engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cochlear implant induced changes in cortical networks associated with tinnitus severity. 人工耳蜗诱导的皮质网络变化与耳鸣严重程度有关。
Pub Date : 2024-09-10 DOI: 10.1088/1741-2552/ad731d
Mehrnaz Shoushtarian, Jamal Esmaelpoor, Michelle M G Bravo, James B Fallon

Objective.We investigated tinnitus-related cortical networks in cochlear implant users who experience tinnitus and whose perception of tinnitus changes with use of their implant. Tinnitus, the perception of unwanted sounds which are not present externally, can be a debilitating condition. In individuals with cochlear implants, use of the implant is known to modulate tinnitus, often improving symptoms but worsening them in some cases. Little is known about underlying cortical changes with use of the implant, which lead to changes in tinnitus perception. In this study we investigated whether changes in brain networks with the cochlear implant turned on and off, were associated with changes in tinnitus perception, as rated subjectively.Approach.Using functional near-infrared spectroscopy, we recorded cortical activity at rest, from 14 cochlear implant users who experienced tinnitus. Recordings were performed with the cochlear implant turned off and on. For each condition, participants rated the loudness and annoyance of their tinnitus using a visual rating scale. Changes in neural synchrony have been reported in humans and animal models of tinnitus. To assess neural synchrony, functional connectivity networks with the implant turned on and off, were compared using two network features: node strength and diversity coefficient.Main results.Changes in subjective ratings of loudness were significantly correlated with changes in node strength, averaged across occipital channels (r=-0.65, p=0.01). Changes in both loudness and annoyance were significantly correlated with changes in diversity coefficient averaged across all channels (r=-0.79,p<0.001 and r=-0.86,p<0.001). More distributed connectivity with the implant on, compared to implant off, was associated with a reduction in tinnitus loudness and annoyance.Significance.A better understanding of neural mechanisms underlying tinnitus suppression with cochlear implant use, could lead to their application as a tinnitus treatment and pave the way for effective use of other less invasive stimulation-based treatments.

目的:我们研究了耳蜗植入者与耳鸣相关的皮层网络,这些植入者会出现耳鸣,而且他们对耳鸣的感知会随着植入体的使用而发生变化。 耳鸣是指感知到外部不存在的不想要的声音,可能会使人衰弱。对于植入人工耳蜗的患者来说,使用人工耳蜗会调节耳鸣,通常会改善症状,但在某些情况下也会加重症状。人们对使用植入体导致耳鸣感知变化的潜在皮质变化知之甚少。在这项研究中,我们调查了人工耳蜗开启和关闭时大脑网络的变化是否与主观评价的耳鸣感知变化有关:我们使用功能性近红外光谱(fNIRS)记录了 14 名耳蜗植入者在静息状态下的大脑皮层活动,他们都有耳鸣症状。记录是在人工耳蜗关闭和打开的情况下进行的。在每种情况下,参与者使用视觉评分表对耳鸣的响度和烦扰程度进行评分。神经同步性的变化已在人类和耳鸣动物模型中有所报道。为了评估神经同步性,研究人员使用节点强度和多样性系数这两个网络特征对植入物开启和关闭时的功能连接网络进行了比较:从枕叶通道的平均值来看,响度主观评分的变化与节点强度的变化有显著相关性(r=-0.65,p = 0.01)。响度和烦扰度的变化与所有通道平均的多样性系数的变化呈显著相关(r=-0.79,p
{"title":"Cochlear implant induced changes in cortical networks associated with tinnitus severity.","authors":"Mehrnaz Shoushtarian, Jamal Esmaelpoor, Michelle M G Bravo, James B Fallon","doi":"10.1088/1741-2552/ad731d","DOIUrl":"10.1088/1741-2552/ad731d","url":null,"abstract":"<p><p><i>Objective.</i>We investigated tinnitus-related cortical networks in cochlear implant users who experience tinnitus and whose perception of tinnitus changes with use of their implant. Tinnitus, the perception of unwanted sounds which are not present externally, can be a debilitating condition. In individuals with cochlear implants, use of the implant is known to modulate tinnitus, often improving symptoms but worsening them in some cases. Little is known about underlying cortical changes with use of the implant, which lead to changes in tinnitus perception. In this study we investigated whether changes in brain networks with the cochlear implant turned on and off, were associated with changes in tinnitus perception, as rated subjectively.<i>Approach.</i>Using functional near-infrared spectroscopy, we recorded cortical activity at rest, from 14 cochlear implant users who experienced tinnitus. Recordings were performed with the cochlear implant turned off and on. For each condition, participants rated the loudness and annoyance of their tinnitus using a visual rating scale. Changes in neural synchrony have been reported in humans and animal models of tinnitus. To assess neural synchrony, functional connectivity networks with the implant turned on and off, were compared using two network features: node strength and diversity coefficient.<i>Main results.</i>Changes in subjective ratings of loudness were significantly correlated with changes in node strength, averaged across occipital channels (r=-0.65, p=0.01). Changes in both loudness and annoyance were significantly correlated with changes in diversity coefficient averaged across all channels (r=-0.79,p<0.001 and r=-0.86,p<0.001). More distributed connectivity with the implant on, compared to implant off, was associated with a reduction in tinnitus loudness and annoyance.<i>Significance.</i>A better understanding of neural mechanisms underlying tinnitus suppression with cochlear implant use, could lead to their application as a tinnitus treatment and pave the way for effective use of other less invasive stimulation-based treatments.</p>","PeriodicalId":94096,"journal":{"name":"Journal of neural engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound pulse repetition frequency preferentially activates different neuron populations independent of cell type. 超声脉冲重复频率可优先激活不同的神经元群,而与细胞类型无关。
Pub Date : 2024-09-09 DOI: 10.1088/1741-2552/ad731c
Jack Sherman, Emma Bortz, Erynne San Antonio, Hua-An Tseng, Laura Raiff, Xue Han

Objective. Transcranial ultrasound (US) stimulation serves as an external input to a neuron, and thus the evoked response relies on neurons' intrinsic properties. Neural activity is limited to a couple hundred hertz and often exhibits preference to input frequencies. Accordingly, US pulsed at specific physiologic pulse repetition frequencies (PRFs) may selectively engage neurons with the corresponding input frequency preference. However, most US parametric studies examine the effects of supraphysiologic PRFs. It remains unclear whether pulsing US at different physiologic PRFs could activate distinct neurons in the awake mammalian brain.Approach. We recorded cellular calcium responses of individual motor cortex neurons to US pulsed at PRFs of 10, 40, and 140 Hz in awake mice. We compared the evoked responses across these PRFs in the same neurons. To further understand the cell-type dependent effects, we categorized the recorded neurons as parvalbumin positive fast spiking interneurons or putative excitatory neurons and analyzed single-cell mechanosensitive channel expression in mice and humans using the Allen Brain Institute's RNA-sequencing databases.Main results. We discovered that many neurons were preferentially activated by only one PRF and different PRFs selectively engaged distinct neuronal populations. US-evoked cellular calcium responses exhibited the same characteristics as those naturally occurring during spiking, suggesting that US increases intrinsic neuronal activity. Furthermore, evoked responses were similar between fast-spiking inhibitory neurons and putative excitatory neurons. Thus, variation in individual neuron's cellular properties dominates US-evoked response heterogeneity, consistent with our observed cell-type independent expression patterns of mechanosensitive channels across individual neurons in mice and humans. Finally, US transiently increased network synchrony without producing prolonged over-synchronization that could be detrimental to neural circuit functions.Significance. These results highlight the feasibility of activating distinct neuronal subgroups by varying PRF and the potential to improve neuromodulation effects by combining physiologic PRFs.

目的经颅超声刺激是神经元的外部输入,因此诱发反应依赖于神经元的内在特性。神经活动仅限于几百赫兹,而且通常对输入频率有偏好。因此,以特定生理脉冲重复频率(PRF)发出的超声波可选择性地吸引具有相应输入频率偏好的神经元。然而,大多数超声参数研究都是研究超生理脉冲重复频率的效果。目前仍不清楚不同生理 PRF 的脉冲超声是否能激活清醒哺乳动物大脑中不同的神经元:我们在清醒的小鼠体内记录了单个运动皮层神经元对 PRF 为 10、40 和 140 Hz 的脉冲超声的细胞钙反应。我们比较了同一神经元在不同 PRF 下的诱发反应。为了进一步了解细胞类型依赖效应,我们将记录的神经元归类为parvalbumin阳性快速尖峰中间神经元或假定兴奋神经元,并利用艾伦脑研究所的RNA测序数据库分析了小鼠和人类单细胞机械敏感通道的表达:我们发现,许多神经元只被一种 PRF 优先激活,而不同的 PRF 会选择性地激活不同的神经元群。超声诱发的细胞钙反应表现出与尖峰冲刺时自然发生的反应相同的特征,这表明超声增加了神经元的内在活动。此外,快速尖峰抑制性神经元和假定兴奋性神经元之间的诱发反应相似。因此,单个神经元细胞特性的变化主导了超声诱发反应的异质性,这与我们观察到的小鼠和人类单个神经元机械敏感通道独立于细胞类型的表达模式是一致的。最后,超声波能短暂提高网络同步性,但不会产生可能对神经回路功能有害的长期过度同步:这些结果凸显了通过改变 PRF 激活不同神经元亚群的可行性,以及通过结合生理 PRF 改善神经调节效果的潜力。
{"title":"Ultrasound pulse repetition frequency preferentially activates different neuron populations independent of cell type.","authors":"Jack Sherman, Emma Bortz, Erynne San Antonio, Hua-An Tseng, Laura Raiff, Xue Han","doi":"10.1088/1741-2552/ad731c","DOIUrl":"10.1088/1741-2552/ad731c","url":null,"abstract":"<p><p><i>Objective</i>. Transcranial ultrasound (US) stimulation serves as an external input to a neuron, and thus the evoked response relies on neurons' intrinsic properties. Neural activity is limited to a couple hundred hertz and often exhibits preference to input frequencies. Accordingly, US pulsed at specific physiologic pulse repetition frequencies (PRFs) may selectively engage neurons with the corresponding input frequency preference. However, most US parametric studies examine the effects of supraphysiologic PRFs. It remains unclear whether pulsing US at different physiologic PRFs could activate distinct neurons in the awake mammalian brain.<i>Approach</i>. We recorded cellular calcium responses of individual motor cortex neurons to US pulsed at PRFs of 10, 40, and 140 Hz in awake mice. We compared the evoked responses across these PRFs in the same neurons. To further understand the cell-type dependent effects, we categorized the recorded neurons as parvalbumin positive fast spiking interneurons or putative excitatory neurons and analyzed single-cell mechanosensitive channel expression in mice and humans using the Allen Brain Institute's RNA-sequencing databases.<i>Main results</i>. We discovered that many neurons were preferentially activated by only one PRF and different PRFs selectively engaged distinct neuronal populations. US-evoked cellular calcium responses exhibited the same characteristics as those naturally occurring during spiking, suggesting that US increases intrinsic neuronal activity. Furthermore, evoked responses were similar between fast-spiking inhibitory neurons and putative excitatory neurons. Thus, variation in individual neuron's cellular properties dominates US-evoked response heterogeneity, consistent with our observed cell-type independent expression patterns of mechanosensitive channels across individual neurons in mice and humans. Finally, US transiently increased network synchrony without producing prolonged over-synchronization that could be detrimental to neural circuit functions.<i>Significance</i>. These results highlight the feasibility of activating distinct neuronal subgroups by varying PRF and the potential to improve neuromodulation effects by combining physiologic PRFs.</p>","PeriodicalId":94096,"journal":{"name":"Journal of neural engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11381926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing upper limb motor dysfunction with temporal and spatial distribution of muscle synergy extracted from high-density surface electromyography. 利用从高密度表面肌电图中提取的肌肉协同作用的时间和空间分布,确定上肢运动功能障碍的特征。
Pub Date : 2024-09-06 DOI: 10.1088/1741-2552/ad6fd5
Haoshi Zhang, Boxing Peng, Ziyin Chen, Yinghu Peng, Xiaomeng Zhou, Yanjuan Geng, Guanglin Li

Objective.To promote the development of objective and comprehensive motion function assessment for patients, based on high-density surface electromyography (HD-sEMG), this study investigates the temporal and spatial variations of neuromuscular activities related to upper limb motor dysfunction.Approach.Patients with unilateral upper limb motor dysfunction and healthy controls were enrolled in the study. HD-sEMG was collected from both arms while they were performing eight hand and wrist movements. Muscle synergies were extracted from the HD-sEMG. Symmetry of bilateral upper limb synergies and synergy differences between motions were proposed as spatial indicators to measure alterations in synergy spatial distribution. Additionally, as a temporal characteristic, the correlation of bilateral upper limb activation coefficient was proposed to describe the coordination control of the central nervous system. All temporal and spatial indicators were compared between patients and healthy subjects.Main results.The patients showed a significant decrease (p< 0.05) in the symmetry of bilateral upper limb synergy spatial distribution and correlation of bilateral upper limb activation coefficient. Patients with motor dysfunction also showed an increase in synergy similarity between motions, indicating altered spatial distribution of muscle synergies.Significance.These findings provide valuable insights into specific patterns associated with motor dysfunction, informing motor function assessment, and guiding targeted interventions and rehabilitation strategies for neurologically disordered patients.

研究目的为促进基于高密度表面肌电图(HD-sEMG)的客观、全面的患者运动功能评估的发展,本研究调查了与上肢运动功能障碍相关的神经肌肉活动的时空变化:方法:研究对象为单侧上肢运动功能障碍患者和健康对照组。在患者进行八次手部和腕部运动时,对其双臂进行 HD-sEMG 采集。从 HD-sEMG 中提取肌肉协同作用。双侧上肢协同作用的对称性和不同动作之间的协同作用差异被认为是测量协同作用空间分布变化的空间指标。此外,还提出了双侧上肢激活系数的相关性作为时间特征,以描述中枢神经系统(CNS)的协调控制。对患者和健康人的所有时间和空间指标进行了比较:主要结果:患者的中枢神经系统协调控制能力明显降低(p<0.05):这些发现为了解与运动功能障碍相关的特定模式提供了有价值的见解,为运动功能评估提供了信息,并为神经障碍性患者的针对性干预和康复策略提供了指导。
{"title":"Characterizing upper limb motor dysfunction with temporal and spatial distribution of muscle synergy extracted from high-density surface electromyography.","authors":"Haoshi Zhang, Boxing Peng, Ziyin Chen, Yinghu Peng, Xiaomeng Zhou, Yanjuan Geng, Guanglin Li","doi":"10.1088/1741-2552/ad6fd5","DOIUrl":"10.1088/1741-2552/ad6fd5","url":null,"abstract":"<p><p><i>Objective.</i>To promote the development of objective and comprehensive motion function assessment for patients, based on high-density surface electromyography (HD-sEMG), this study investigates the temporal and spatial variations of neuromuscular activities related to upper limb motor dysfunction.<i>Approach.</i>Patients with unilateral upper limb motor dysfunction and healthy controls were enrolled in the study. HD-sEMG was collected from both arms while they were performing eight hand and wrist movements. Muscle synergies were extracted from the HD-sEMG. Symmetry of bilateral upper limb synergies and synergy differences between motions were proposed as spatial indicators to measure alterations in synergy spatial distribution. Additionally, as a temporal characteristic, the correlation of bilateral upper limb activation coefficient was proposed to describe the coordination control of the central nervous system. All temporal and spatial indicators were compared between patients and healthy subjects.<i>Main results.</i>The patients showed a significant decrease (<i>p</i>< 0.05) in the symmetry of bilateral upper limb synergy spatial distribution and correlation of bilateral upper limb activation coefficient. Patients with motor dysfunction also showed an increase in synergy similarity between motions, indicating altered spatial distribution of muscle synergies.<i>Significance.</i>These findings provide valuable insights into specific patterns associated with motor dysfunction, informing motor function assessment, and guiding targeted interventions and rehabilitation strategies for neurologically disordered patients.</p>","PeriodicalId":94096,"journal":{"name":"Journal of neural engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding working-memory load duringn-back task performance from high channel fNIRS data. 从高通道 fNIRS 数据解码 n-Back 任务执行过程中的工作记忆负荷。
Pub Date : 2024-09-06 DOI: 10.1088/1741-2552/ad731b
Christian Kothe, Grant Hanada, Sean Mullen, Tim Mullen

Objective.Functional near-infrared spectroscopy (fNIRS) can measure neural activity through blood oxygenation changes in the brain in a wearable form factor, enabling unique applications for research in and outside the lab and in practical occupational settings. fNIRS has proven capable of measuring cognitive states such as mental workload, often using machine learning (ML) based brain-computer interfaces (BCIs). To date, this research has largely relied on probes with channel counts from under ten to several hundred, although recently a new class of wearable NIRS devices featuring thousands of channels has emerged. This poses unique challenges for ML classification, as fNIRS is typically limited by few training trials which results in severely under-determined estimation problems. So far, it is not well understood how such high-resolution data is best leveraged in practical BCIs and whether state-of-the-art or better performance can be achieved.Approach.To address these questions, we propose an ML strategy to classify working-memory load that relies on spatio-temporal regularization and transfer learning from other subjects in a combination that, to our knowledge, has not been used in previous fNIRS BCIs. The approach can be interpreted as an end-to-end generalized linear model and allows for a high degree of interpretability using channel-level or cortical imaging approaches.Main results.We show that using the proposed methodology, it is possible to achieve state-of-the-art decoding performance with high-resolution fNIRS data. We also replicated several state-of-the-art approaches on our dataset of 43 participants wearing a 3198 dual-channel NIRS device while performing then-Back task and show that these existing methodologies struggle in the high-channel regime and are largely outperformed by the proposed pipeline.Significance.Our approach helps establish high-channel NIRS devices as a viable platform for state-of-the-art BCI and opens new applications using this class of headset while also enabling high-resolution model imaging and interpretation.

目的:功能性近红外光谱(fNIRS)可以通过大脑中的血氧变化测量神经活动,它采用了可穿戴的形式,能够在实验室内外的研究和实际职业环境中实现独特的应用。事实证明,fNIRS 能够测量认知状态,如精神工作量,通常使用基于机器学习(ML)的脑机接口(BCI)。迄今为止,这项研究主要依赖于通道数从十个以下到几百个不等的探头,不过最近出现了一类具有数千个通道的新型可穿戴近红外设备。这给 ML 分类带来了独特的挑战,因为 fNIRS 通常受限于较少的训练试验,从而导致严重的估计不足问题。到目前为止,人们还不太了解如何在实际 BCI 中最好地利用这种高分辨率数据,以及是否能实现最先进或更好的性能:为了解决这些问题,我们提出了一种 ML 策略来对工作记忆负荷进行分类,该策略依赖于时空正则化和其他科目的迁移学习,据我们所知,这种组合在以前的 fNIRS BCIs 中从未使用过。这种方法可被解释为端到端的广义线性模型,并允许使用通道级或皮层成像方法进行高度解释:我们的研究表明,使用所提出的方法,可以通过高分辨率 fNIRS 数据实现最先进的解码性能。我们还在由 43 名佩戴 3198 双通道 NIRS 设备的参与者组成的数据集上复制了几种最先进的方法,同时执行了 n-Back 任务:我们的方法有助于将高通道近红外设备确立为最先进的生物识别(BCI)的可行平台,并利用这类耳机开辟了新的应用领域,同时还实现了高分辨率模型成像和解释。
{"title":"Decoding working-memory load during<i>n</i>-back task performance from high channel fNIRS data.","authors":"Christian Kothe, Grant Hanada, Sean Mullen, Tim Mullen","doi":"10.1088/1741-2552/ad731b","DOIUrl":"10.1088/1741-2552/ad731b","url":null,"abstract":"<p><p><i>Objective.</i>Functional near-infrared spectroscopy (fNIRS) can measure neural activity through blood oxygenation changes in the brain in a wearable form factor, enabling unique applications for research in and outside the lab and in practical occupational settings. fNIRS has proven capable of measuring cognitive states such as mental workload, often using machine learning (ML) based brain-computer interfaces (BCIs). To date, this research has largely relied on probes with channel counts from under ten to several hundred, although recently a new class of wearable NIRS devices featuring thousands of channels has emerged. This poses unique challenges for ML classification, as fNIRS is typically limited by few training trials which results in severely under-determined estimation problems. So far, it is not well understood how such high-resolution data is best leveraged in practical BCIs and whether state-of-the-art or better performance can be achieved.<i>Approach.</i>To address these questions, we propose an ML strategy to classify working-memory load that relies on spatio-temporal regularization and transfer learning from other subjects in a combination that, to our knowledge, has not been used in previous fNIRS BCIs. The approach can be interpreted as an end-to-end generalized linear model and allows for a high degree of interpretability using channel-level or cortical imaging approaches.<i>Main results.</i>We show that using the proposed methodology, it is possible to achieve state-of-the-art decoding performance with high-resolution fNIRS data. We also replicated several state-of-the-art approaches on our dataset of 43 participants wearing a 3198 dual-channel NIRS device while performing the<i>n</i>-Back task and show that these existing methodologies struggle in the high-channel regime and are largely outperformed by the proposed pipeline.<i>Significance.</i>Our approach helps establish high-channel NIRS devices as a viable platform for state-of-the-art BCI and opens new applications using this class of headset while also enabling high-resolution model imaging and interpretation.</p>","PeriodicalId":94096,"journal":{"name":"Journal of neural engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distraction impact of concurrent conversation on event-related potential based brain-computer interfaces. 同时进行的对话对基于事件相关电位的脑机接口的分心影响。
Pub Date : 2024-09-05 DOI: 10.1088/1741-2552/ad731e
Minju Kim, Sung-Phil Kim

Objective.This study investigates the impact of conversation on the performance of visual event-related potential (ERP)-based brain-computer interfaces (BCIs), considering distractions in real life environment. The research aims to understand how cognitive distractions from speaking and listening activities affect ERP-BCI performance.Approach.The experiment employs a dual-task paradigm where participants control a smart light using visual ERP-BCIs while simultaneously conducting speaking or listening tasks.Main results.The findings reveal that speaking notably degrades BCI accuracy and the amplitude of ERP components, while increases the latency variability of ERP components and occipital alpha power. In contrast, listening and simple syllable repetition tasks have a lesser impact on these variables. The results suggest that speaking activity significantly distracts visual attentional processes critical for BCI operationSignificance. This study highlights the need to take distractions by daily conversation into account of the design and implementation of ERP-BCIs.

研究目的本研究调查了交谈对基于视觉事件相关电位(ERP)的脑机接口(BCI)性能的影响,同时考虑了现实生活环境中的分心因素。研究旨在了解说话和聆听活动的认知分心如何影响 ERP-BCI 的性能:实验采用了双任务范式,参与者在使用视觉ERP-BCI控制智能灯的同时进行说话或倾听任务:研究结果表明,说话会明显降低BCI的准确性和ERP成分的振幅,同时增加ERP成分的延迟变异性和枕骨α功率。相比之下,听力和简单音节重复任务对这些变量的影响较小。结果表明,说话活动会极大地分散对 BCI 操作至关重要的视觉注意过程。本研究强调了在设计和实施 ERP-BCI 时考虑到日常对话干扰的必要性。
{"title":"Distraction impact of concurrent conversation on event-related potential based brain-computer interfaces.","authors":"Minju Kim, Sung-Phil Kim","doi":"10.1088/1741-2552/ad731e","DOIUrl":"10.1088/1741-2552/ad731e","url":null,"abstract":"<p><p><i>Objective.</i>This study investigates the impact of conversation on the performance of visual event-related potential (ERP)-based brain-computer interfaces (BCIs), considering distractions in real life environment. The research aims to understand how cognitive distractions from speaking and listening activities affect ERP-BCI performance.<i>Approach.</i>The experiment employs a dual-task paradigm where participants control a smart light using visual ERP-BCIs while simultaneously conducting speaking or listening tasks.<i>Main results.</i>The findings reveal that speaking notably degrades BCI accuracy and the amplitude of ERP components, while increases the latency variability of ERP components and occipital alpha power. In contrast, listening and simple syllable repetition tasks have a lesser impact on these variables. The results suggest that speaking activity significantly distracts visual attentional processes critical for BCI operation<i>Significance</i>. This study highlights the need to take distractions by daily conversation into account of the design and implementation of ERP-BCIs.</p>","PeriodicalId":94096,"journal":{"name":"Journal of neural engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilizing diffusion tensor imaging as an image biomarker in exploring the therapeutic efficacy of forniceal deep brain stimulation in a mice model of Alzheimer's disease. 利用弥散张量成像作为图像生物标志物,探索在阿尔茨海默病小鼠模型中使用穹窿深部脑刺激疗法的疗效。
Pub Date : 2024-09-04 DOI: 10.1088/1741-2552/ad7322
You-Yin Chen, Chih-Ju Chang, Yao-Wen Liang, Hsin-Yi Tseng, Ssu-Ju Li, Ching-Wen Chang, Yen-Ting Wu, Huai-Hsuan Shao, Po-Chun Chen, Ming-Liang Lai, Wen-Chun Deng, RuSiou Hsu, Yu-Chun Lo

Objective.With prolonged life expectancy, the incidence of memory deficits, especially in Alzheimer's disease (AD), has increased. Although multiple treatments have been evaluated, no promising treatment has been found to date. Deep brain stimulation (DBS) of the fornix area was explored as a possible treatment because the fornix is intimately connected to memory-related areas that are vulnerable in AD; however, a proper imaging biomarker for assessing the therapeutic efficiency of forniceal DBS in AD has not been established.Approach.This study assessed the efficacy and safety of DBS by estimating the optimal intersection volume between the volume of tissue activated and the fornix. Utilizing a gold-electroplating process, the microelectrode's surface area on the neural probe was increased, enhancing charge transfer performance within potential water window limits. Bilateral fornix implantation was conducted in triple-transgenic AD mice (3 × Tg-AD) and wild-type mice (strain: B6129SF1/J), with forniceal DBS administered exclusively to 3 × Tg-AD mice in the DBS-on group. Behavioral tasks, diffusion tensor imaging (DTI), and immunohistochemistry (IHC) were performed in all mice to assess the therapeutic efficacy of forniceal DBS.Main results.The results illustrated that memory deficits and increased anxiety-like behavior in 3 × Tg-AD mice were rescued by forniceal DBS. Furthermore, forniceal DBS positively altered DTI indices, such as increasing fractional anisotropy (FA) and decreasing mean diffusivity (MD), together with reducing microglial cell and astrocyte counts, suggesting a potential causal relationship between revised FA/MD and reduced cell counts in the anterior cingulate cortex, hippocampus, fornix, amygdala, and entorhinal cortex of 3 × Tg-AD mice following forniceal DBS.Significance.The efficacy of forniceal DBS in AD can be indicated by alterations in DTI-based biomarkers reflecting the decreased activation of glial cells, suggesting reduced neural inflammation as evidenced by improvements in memory and anxiety-like behavior.

目的:随着预期寿命的延长,记忆障碍的发病率也在增加,尤其是阿尔茨海默病(AD)。虽然已对多种治疗方法进行了评估,但迄今为止尚未发现有前景的治疗方法。由于穹窿与记忆相关区域紧密相连,而记忆相关区域在阿兹海默症(AD)中很脆弱,因此对穹窿区域进行深部脑刺激(DBS)被视为一种可能的治疗方法;然而,评估穹窿DBS对阿兹海默症(AD)治疗效果的适当成像生物标志物尚未确立。利用镀金工艺,增加了神经探针上微电极的表面积,在潜在水窗限制范围内提高了电荷转移性能。在三转基因AD小鼠(3 × Tg-AD)和野生型小鼠(品系:B6129SF1/J)中进行了双侧穹窿植入,DBS开启组中的3 × Tg-AD小鼠只接受穹窿DBS治疗。主要结果:结果表明,3 × Tg-AD 小鼠的记忆缺陷和焦虑样行为的增加通过穹窿DBS得到了挽救。此外,穹窿DBS还能正向改变DTI指数,如增加分数各向异性(FA)和降低平均扩散率(MD),同时减少小胶质细胞和星形胶质细胞的数量,这表明穹窿DBS治疗后,3 × Tg-AD小鼠前扣带回皮层、海马、穹窿、杏仁核和内侧皮层的FA/MD改变和细胞数量减少之间可能存在因果关系。穹窿DBS对AD的疗效可以通过基于DTI的生物标志物的改变来体现,这些生物标志物反映了神经胶质细胞活化的减少,表明神经炎症的减轻,记忆力和焦虑样行为的改善也证明了这一点。
{"title":"Utilizing diffusion tensor imaging as an image biomarker in exploring the therapeutic efficacy of forniceal deep brain stimulation in a mice model of Alzheimer's disease.","authors":"You-Yin Chen, Chih-Ju Chang, Yao-Wen Liang, Hsin-Yi Tseng, Ssu-Ju Li, Ching-Wen Chang, Yen-Ting Wu, Huai-Hsuan Shao, Po-Chun Chen, Ming-Liang Lai, Wen-Chun Deng, RuSiou Hsu, Yu-Chun Lo","doi":"10.1088/1741-2552/ad7322","DOIUrl":"10.1088/1741-2552/ad7322","url":null,"abstract":"<p><p><i>Objective.</i>With prolonged life expectancy, the incidence of memory deficits, especially in Alzheimer's disease (AD), has increased. Although multiple treatments have been evaluated, no promising treatment has been found to date. Deep brain stimulation (DBS) of the fornix area was explored as a possible treatment because the fornix is intimately connected to memory-related areas that are vulnerable in AD; however, a proper imaging biomarker for assessing the therapeutic efficiency of forniceal DBS in AD has not been established.<i>Approach.</i>This study assessed the efficacy and safety of DBS by estimating the optimal intersection volume between the volume of tissue activated and the fornix. Utilizing a gold-electroplating process, the microelectrode's surface area on the neural probe was increased, enhancing charge transfer performance within potential water window limits. Bilateral fornix implantation was conducted in triple-transgenic AD mice (3 × Tg-AD) and wild-type mice (strain: B6129SF1/J), with forniceal DBS administered exclusively to 3 × Tg-AD mice in the DBS-on group. Behavioral tasks, diffusion tensor imaging (DTI), and immunohistochemistry (IHC) were performed in all mice to assess the therapeutic efficacy of forniceal DBS.<i>Main results.</i>The results illustrated that memory deficits and increased anxiety-like behavior in 3 × Tg-AD mice were rescued by forniceal DBS. Furthermore, forniceal DBS positively altered DTI indices, such as increasing fractional anisotropy (FA) and decreasing mean diffusivity (MD), together with reducing microglial cell and astrocyte counts, suggesting a potential causal relationship between revised FA/MD and reduced cell counts in the anterior cingulate cortex, hippocampus, fornix, amygdala, and entorhinal cortex of 3 × Tg-AD mice following forniceal DBS.<i>Significance.</i>The efficacy of forniceal DBS in AD can be indicated by alterations in DTI-based biomarkers reflecting the decreased activation of glial cells, suggesting reduced neural inflammation as evidenced by improvements in memory and anxiety-like behavior.</p>","PeriodicalId":94096,"journal":{"name":"Journal of neural engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Motor imagery with cues in virtual reality, audio and screen. 通过虚拟现实、音频和屏幕的提示进行运动想象。
Pub Date : 2024-09-04 DOI: 10.1088/1741-2552/ad775e
Sonal Santosh Baberwal, Luz Alejandra Magre, K R Sanjaya D Gunawardhana, Michael Parkinson, Tomas Ward, Shirley Coyle

Objective: Training plays a significant role in motor imagery (MI), particularly in applications such as Motor Imagery-based Brain-Computer Interface (MIBCI) systems and rehabilitation systems. Previous studies have investigated the intricate relationship between cues and MI signals. However, the medium of presentation still remains an emerging area to be explored, as possible factors to enhance Motor Imagery signals.. Approach: We hypothesise that the medium used for cue presentation can significantly influence both performance and training outcomes in MI tasks. To test this hypothesis, we designed and executed an experiment implementing no- feedback MI. Our investigation focused on three distinct cue presentation mediums -audio, screen, and virtual reality(VR) headsets-all of which have potential implications for BCI use in the Activities of Daily Lives. Main Results: The results of our study uncovered notable variations in MI signals depending on the medium of cue presentation, where the analysis is based on 3 EEG channels. To substantiate our findings, we employed a comprehensive approach, utilizing various evaluation metrics including Event- Related Synchronisation(ERS)/Desynchronisation(ERD), Feature Extraction (using Recursive Feature Elimination (RFE)), Machine Learning methodologies (using Ensemble Learning), and participant Questionnaires. All the approaches signify that Motor Imagery signals are enhanced when presented in VR, followed by audio, and lastly screen. Applying a Machine Learning approach across all subjects, the mean cross-validation accuracy (Mean ± Std. Error) was 69.24 ± 3.12, 68.69 ± 3.3 and 66.1±2.59 when for the VR, audio-based, and screen-based instructions respectively. Significance: This multi-faceted exploration provides evidence to inform MI- based BCI design and advocates the incorporation of different mediums into the design of MIBCI systems, experimental setups, and user studies. The influence of the medium used for cue presentation may be applied to develop more effective and inclusive MI applications in the realm of human-computer interaction and rehabilitation.

目的:训练在运动想象(MI)中发挥着重要作用,尤其是在基于运动想象的脑机接口(MIBCI)系统和康复系统等应用中。以往的研究已经探究了线索与运动想象信号之间错综复杂的关系。然而,作为增强运动想象信号的可能因素,呈现媒介仍然是一个有待探索的新兴领域:我们假设,提示呈现的媒介会显著影响运动智能任务的表现和训练结果。为了验证这一假设,我们设计并实施了一项无反馈移动迷宫实验。我们的研究侧重于三种不同的提示呈现媒介--音频、屏幕和虚拟现实(VR)头盔--所有这些媒介都对在日常生活活动中使用生物识别(BCI)具有潜在影响:我们的研究结果揭示了 MI 信号的显著差异,这取决于提示呈现的媒介,其中分析基于 3 个脑电图通道。为了证实我们的研究结果,我们采用了一种综合方法,利用各种评估指标,包括事件相关同步(ERS)/不同步(ERD)、特征提取(使用递归特征消除(RFE))、机器学习方法(使用集合学习)和参与者问卷调查。所有方法都表明,运动图像信号在 VR 中呈现时会得到增强,其次是音频,最后是屏幕。在所有受试者中应用机器学习方法,VR、音频和屏幕指令的交叉验证平均准确率(平均值±标准误差)分别为 69.24 ± 3.12、68.69 ± 3.3 和 66.1 ± 2.59:这一多方面的探索为基于 MI 的 BCI 设计提供了依据,并倡导在 MIBCI 系统设计、实验设置和用户研究中采用不同的媒介。在人机交互和康复领域,提示呈现媒介的影响可用于开发更有效、更具包容性的多元智能应用。
{"title":"Motor imagery with cues in virtual reality, audio and screen.","authors":"Sonal Santosh Baberwal, Luz Alejandra Magre, K R Sanjaya D Gunawardhana, Michael Parkinson, Tomas Ward, Shirley Coyle","doi":"10.1088/1741-2552/ad775e","DOIUrl":"https://doi.org/10.1088/1741-2552/ad775e","url":null,"abstract":"<p><strong>Objective: </strong>Training plays a significant role in motor imagery (MI), particularly in applications such as Motor Imagery-based Brain-Computer Interface (MIBCI) systems and rehabilitation systems. Previous studies have investigated the intricate relationship between cues and MI signals. However, the medium of presentation still remains an emerging area to be explored, as possible factors to enhance Motor Imagery signals..&#xD;Approach: We hypothesise that the medium used for cue presentation can significantly influence both performance and training outcomes in MI tasks. To test this hypothesis, we designed and executed an experiment implementing no- feedback MI. Our investigation focused on three distinct cue presentation mediums -audio, screen, and virtual reality(VR) headsets-all of which have potential implications for BCI use in the Activities of Daily Lives.&#xD;Main Results: The results of our study uncovered notable variations in MI signals depending on the medium of cue presentation, where the analysis is based on 3 EEG channels. To substantiate our findings, we employed a comprehensive approach, utilizing various evaluation metrics including Event- Related Synchronisation(ERS)/Desynchronisation(ERD), Feature Extraction (using Recursive Feature Elimination (RFE)), Machine Learning methodologies (using Ensemble Learning), and participant Questionnaires. All the approaches signify that Motor Imagery signals are enhanced when presented in VR, followed by audio, and lastly screen. Applying a Machine Learning approach across all subjects, the mean cross-validation accuracy (Mean ± Std. Error) was 69.24 ± 3.12, 68.69 ± 3.3 and 66.1±2.59 when for the VR, audio-based, and screen-based instructions respectively.&#xD;Significance: This multi-faceted exploration provides evidence to inform MI- based BCI design and advocates the incorporation of different mediums into the design of MIBCI systems, experimental setups, and user studies. The influence of the medium used for cue presentation may be applied to develop more effective and inclusive MI applications in the realm of human-computer interaction and rehabilitation.</p>","PeriodicalId":94096,"journal":{"name":"Journal of neural engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of neural engineering
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1