Background / Aims: As estrogens play a neuroprotective role, the decline in their concentrations during menopause may compromise cognitive function in postmenopausal women. Whether early menopause (EM) is associated with an increased risk of dementia remains unclear. The purpose of this study was to systematically review and meta-analyze current evidence regarding the association between EM or premature ovarian insufficiency (POI) and the risk of dementia of any type.
{"title":"Early menopause and premature ovarian insufficiency are associated with increased risk of dementia: a systematic review and meta-analysis","authors":"Eleni Karamitrou, Panagiotis Anagnostis, Konstantina Vaitsi, Loukas Athanasiadis, Dimitrios Goulis","doi":"10.1016/j.maturitas.2023.04.177","DOIUrl":"https://doi.org/10.1016/j.maturitas.2023.04.177","url":null,"abstract":"Background / Aims: As estrogens play a neuroprotective role, the decline in their concentrations during menopause may compromise cognitive function in postmenopausal women. Whether early menopause (EM) is associated with an increased risk of dementia remains unclear. The purpose of this study was to systematically review and meta-analyze current evidence regarding the association between EM or premature ovarian insufficiency (POI) and the risk of dementia of any type.","PeriodicalId":94131,"journal":{"name":"Maturitas","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Many chronic diseases and their medications may induce sexual problems. This study aimed to evaluate whether general practitioners (GPs) bring up patients’ sexual health issues during appointments with patients who have chronic diseases.
{"title":"Patients with chronic diseases: is sexual health brought up by general practitioners during appointments? – A web-based study","authors":"Päivi Polo-Kantola, Sanna-Mari Manninen, Tero Vahlberg, Katja Kero","doi":"10.1016/j.maturitas.2023.04.055","DOIUrl":"https://doi.org/10.1016/j.maturitas.2023.04.055","url":null,"abstract":"Objectives: Many chronic diseases and their medications may induce sexual problems. This study aimed to evaluate whether general practitioners (GPs) bring up patients’ sexual health issues during appointments with patients who have chronic diseases.","PeriodicalId":94131,"journal":{"name":"Maturitas","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.1016/j.maturitas.2023.04.178
Panagiotis Anagnostis, Christina Antza, Christina Trakatelli, Irene Lambrinoudaki, Dimitrios Goulis, Vasileios Kotsis
Objective: Transition to menopause has been associated with an increased risk of cardiovascular disease (CVD), attributed mainly to atherogenic dyslipidemia. Whether lipoprotein (a) [Lp(a)], an independent cardiovascular risk factor, also contributes to menopause-associated CVD has not yet been clarified. The aim of this study was to systematically investigate and meta-analyze the best available evidence regarding the effect of menopause on Lp(a) concentrations.
{"title":"The effect of menopause on lipoprotein (a) concentrations: a systematic review and meta-analysis","authors":"Panagiotis Anagnostis, Christina Antza, Christina Trakatelli, Irene Lambrinoudaki, Dimitrios Goulis, Vasileios Kotsis","doi":"10.1016/j.maturitas.2023.04.178","DOIUrl":"https://doi.org/10.1016/j.maturitas.2023.04.178","url":null,"abstract":"Objective: Transition to menopause has been associated with an increased risk of cardiovascular disease (CVD), attributed mainly to atherogenic dyslipidemia. Whether lipoprotein (a) [Lp(a)], an independent cardiovascular risk factor, also contributes to menopause-associated CVD has not yet been clarified. The aim of this study was to systematically investigate and meta-analyze the best available evidence regarding the effect of menopause on Lp(a) concentrations.","PeriodicalId":94131,"journal":{"name":"Maturitas","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.1016/j.maturitas.2023.04.207
Nuno Aquilino Muiños Fernández, José Ignacio Pardo González de Quevedo, Maria Pilar Diaz-Merino Martinez, Ildefonso Garcia Martin, Javier Rosado Martin, Maria Palma Santisteban, Eva Garcia Aguilar
Background: Decreased estrogen levels after menopause result in vaginal atrophy, leading to elevated pH, lower levels of Lactobacilli and dysbiosis, increasing the frequency of Urinary Tract Infections (UTIs). Topical estrogens restore the atrophic vagina stimulating the proliferation of a balanced flora and preventing urinary symptoms. This preventive approach can be considered an alternative to the use of long-term antibiotics.
{"title":"Efficacy of a 0.005% estriol vaginal gel in preventing recurrent urinary tract infections in postmenopausal women with vaginal atrophy. Blissure study","authors":"Nuno Aquilino Muiños Fernández, José Ignacio Pardo González de Quevedo, Maria Pilar Diaz-Merino Martinez, Ildefonso Garcia Martin, Javier Rosado Martin, Maria Palma Santisteban, Eva Garcia Aguilar","doi":"10.1016/j.maturitas.2023.04.207","DOIUrl":"https://doi.org/10.1016/j.maturitas.2023.04.207","url":null,"abstract":"Background: Decreased estrogen levels after menopause result in vaginal atrophy, leading to elevated pH, lower levels of Lactobacilli and dysbiosis, increasing the frequency of Urinary Tract Infections (UTIs). Topical estrogens restore the atrophic vagina stimulating the proliferation of a balanced flora and preventing urinary symptoms. This preventive approach can be considered an alternative to the use of long-term antibiotics.","PeriodicalId":94131,"journal":{"name":"Maturitas","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.1016/j.maturitas.2023.04.190
Nicole Jaff
Approximately six million women, globally, will become menopausal annually, with 76% of these living in developing countries. Western studies show that the menopause transition is associated with an increased risk of cardiometabolic disease (CMD), cognitive decline and related risk factors. Longitudinal research found CMD risk factors are increasing, leading to the majority of deaths worldwide, particularly in low- and middle-income countries (LMICs). Data show that CMDs are associated with cognitive decline and subsequent dementia. A laterage at menopause is associated with increased longevity and low morbidity, but women in LMICs, where poor socio-economic conditions are the norm, have been shown to become menopausal earlier than their Western counterparts. A series of socioeconomic challenges, including a lack of adequate human and financial resources to collect robust, accurate data have hindered longitudinal research in LMICs, resulting in a paucity of data on the perimenopause and the increased health risks. Additional challenges includevery limited or no access to gynecological consultations or annual health checkupsfrom under resourced and stressed public health systems, lack of education, and scarcity of information on menopause. Menopause education focussing on modifiable life style risk factors is urgently needed to inform LMIC public healthcare systems and the population, particularly since menopausal hormone therapy is not readily available. However, several challenges suggest that information from Western studies may not be easily generalizable to LMIC women. Cultural and ethnic differencesmay determine a different experience of the MT between LMIC women and their Western counterparts. Socioeconomic status, education level and lifestyle may vary widely. There are limited appropriate screening tools and resources to measure various aspects of the menopause, including accurate staging, CMD risk factors and cognition, meaning menopause research in LMICs focusses primarily on age at menopause, menopausal symptoms and perception of menopause. In order to ensure that women in LMICs receive effective menopause education, there is an urgent need for LMIC menopause research focusing on biological and cultural factors affecting midlife women, using culturally appropriate and validated measures, and carefully designed methodology encompassing the broad range of confounding factors found in LMICs.
{"title":"Does one size fit all? The usefulness of menopause education across low and middle income countries","authors":"Nicole Jaff","doi":"10.1016/j.maturitas.2023.04.190","DOIUrl":"https://doi.org/10.1016/j.maturitas.2023.04.190","url":null,"abstract":"Approximately six million women, globally, will become menopausal annually, with 76% of these living in developing countries. Western studies show that the menopause transition is associated with an increased risk of cardiometabolic disease (CMD), cognitive decline and related risk factors. Longitudinal research found CMD risk factors are increasing, leading to the majority of deaths worldwide, particularly in low- and middle-income countries (LMICs). Data show that CMDs are associated with cognitive decline and subsequent dementia. A laterage at menopause is associated with increased longevity and low morbidity, but women in LMICs, where poor socio-economic conditions are the norm, have been shown to become menopausal earlier than their Western counterparts. A series of socioeconomic challenges, including a lack of adequate human and financial resources to collect robust, accurate data have hindered longitudinal research in LMICs, resulting in a paucity of data on the perimenopause and the increased health risks. Additional challenges includevery limited or no access to gynecological consultations or annual health checkupsfrom under resourced and stressed public health systems, lack of education, and scarcity of information on menopause. Menopause education focussing on modifiable life style risk factors is urgently needed to inform LMIC public healthcare systems and the population, particularly since menopausal hormone therapy is not readily available. However, several challenges suggest that information from Western studies may not be easily generalizable to LMIC women. Cultural and ethnic differencesmay determine a different experience of the MT between LMIC women and their Western counterparts. Socioeconomic status, education level and lifestyle may vary widely. There are limited appropriate screening tools and resources to measure various aspects of the menopause, including accurate staging, CMD risk factors and cognition, meaning menopause research in LMICs focusses primarily on age at menopause, menopausal symptoms and perception of menopause. In order to ensure that women in LMICs receive effective menopause education, there is an urgent need for LMIC menopause research focusing on biological and cultural factors affecting midlife women, using culturally appropriate and validated measures, and carefully designed methodology encompassing the broad range of confounding factors found in LMICs.","PeriodicalId":94131,"journal":{"name":"Maturitas","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135154699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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