Pub Date : 2024-08-01DOI: 10.23736/S0026-4806.24.09097-9
Juliana Trujillo-Gómez, Cristian E Navarro, Santiago Atehortúa-Muñoz, Ivan D Florez
Central nervous system infections are due to different microorganisms such as viruses, bacteria, mycobacteria, fungi, amoebas, and other parasites. The etiology depends on multiple risk factors, and it defines the infection location because some microorganisms prefer meninges, brain tissue, cerebellum, brain stem or spinal cord. The microorganisms induce diseases in the nervous system through direct invasion, neurotoxin production, and the triggered immune response. To determine the infection etiology, there are several diagnostic tests which may be conducted with cerebrospinal fluid, blood, respiratory and stool samples. These tests include but are not limited to direct microscopic examination of the sample, stains, cultures, antigenic tests, nucleic acid amplification tests, metagenomic next-generation sequencing, immunologic biomarker and neuroimaging, especially contrast-enhanced magnetic resonance imaging. The treatment may consist of specific antimicrobial treatment and supportive standard care. Since viruses have no specific antiviral treatment, antimicrobial treatment is mainly targeted at non-viral infections. This article will focus on diagnosis and treatment of acute acquired infections of the central nervous system beyond the neonatal period. The discussion defines the disease, provides the clinical presentation, explains the etiology and risk factors, and briefly mentions potential complications. This updated review aims to provide the reader with all the elements needed to adequately approach a patient with a central nervous system infection. Mycobacterium tuberculosis infection, Cryptococcus spp. infection and vaccines are not within the scope of this article.
{"title":"Acute infections of the central nervous system in children and adults: diagnosis and management.","authors":"Juliana Trujillo-Gómez, Cristian E Navarro, Santiago Atehortúa-Muñoz, Ivan D Florez","doi":"10.23736/S0026-4806.24.09097-9","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09097-9","url":null,"abstract":"<p><p>Central nervous system infections are due to different microorganisms such as viruses, bacteria, mycobacteria, fungi, amoebas, and other parasites. The etiology depends on multiple risk factors, and it defines the infection location because some microorganisms prefer meninges, brain tissue, cerebellum, brain stem or spinal cord. The microorganisms induce diseases in the nervous system through direct invasion, neurotoxin production, and the triggered immune response. To determine the infection etiology, there are several diagnostic tests which may be conducted with cerebrospinal fluid, blood, respiratory and stool samples. These tests include but are not limited to direct microscopic examination of the sample, stains, cultures, antigenic tests, nucleic acid amplification tests, metagenomic next-generation sequencing, immunologic biomarker and neuroimaging, especially contrast-enhanced magnetic resonance imaging. The treatment may consist of specific antimicrobial treatment and supportive standard care. Since viruses have no specific antiviral treatment, antimicrobial treatment is mainly targeted at non-viral infections. This article will focus on diagnosis and treatment of acute acquired infections of the central nervous system beyond the neonatal period. The discussion defines the disease, provides the clinical presentation, explains the etiology and risk factors, and briefly mentions potential complications. This updated review aims to provide the reader with all the elements needed to adequately approach a patient with a central nervous system infection. Mycobacterium tuberculosis infection, Cryptococcus spp. infection and vaccines are not within the scope of this article.</p>","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":"115 4","pages":"476-502"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-30DOI: 10.23736/S0026-4806.24.09294-2
Qingchuan Ma, Ni Mu, Xi Wu, Bing Yang, Na Xu
{"title":"Exploring the impact of Cyp2C19 genetic polymorphism on the neurological and endothelial functions of acute cerebral infarction patients treated with dibenzyline.","authors":"Qingchuan Ma, Ni Mu, Xi Wu, Bing Yang, Na Xu","doi":"10.23736/S0026-4806.24.09294-2","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09294-2","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-22DOI: 10.23736/S0026-4806.24.09330-3
Yeshan Li, Ling Lin, Zhaoyan Wu, Fangfang Bai, Yao Lu, Gang Yang, Shirong Li
{"title":"Diagnostic efficiency and safety evaluation of different groups of lymph nodes in 193 cases of conventional transbronchial needle aspiration (C-TBNA).","authors":"Yeshan Li, Ling Lin, Zhaoyan Wu, Fangfang Bai, Yao Lu, Gang Yang, Shirong Li","doi":"10.23736/S0026-4806.24.09330-3","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09330-3","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-08DOI: 10.23736/S0026-4806.24.09380-7
Juan Tang, Lei Wang, Yang Wang, Chun Man, Ji Li
{"title":"Changes and clinical significance of miR-24 expression in peripheral blood of patients with severe pneumonia.","authors":"Juan Tang, Lei Wang, Yang Wang, Chun Man, Ji Li","doi":"10.23736/S0026-4806.24.09380-7","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09380-7","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-08DOI: 10.23736/S0026-4806.24.09320-0
Lingling Wang, Jun-Hui Zhao, Liping An, Xuehong Li
{"title":"Study on the clinical effect of integrative Chinese and Western medicine in treating endometritis.","authors":"Lingling Wang, Jun-Hui Zhao, Liping An, Xuehong Li","doi":"10.23736/S0026-4806.24.09320-0","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09320-0","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of early cardiac rehabilitation on cardiac function, exercise endurance and Quality of Life in patients with acute myocardial infarction after PCI.","authors":"Caojian Zuo, Ting Gao, Hongkai Zhang, Hexiang Wang, Yang Zhang, Bing Guo","doi":"10.23736/S0026-4806.24.09426-6","DOIUrl":"https://doi.org/10.23736/S0026-4806.24.09426-6","url":null,"abstract":"","PeriodicalId":94143,"journal":{"name":"Minerva medica","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141500016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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