Objective: Data about efficacy and safety of the latest COVID-19 treatments as nirmatrelvir/ritonavir (n/r) or Sotrovimab is scarce in solid organ transplant recipients in the Omicron era. This study aims at describing the outcome of kidney transplant recipients (KTRs) presenting Omicron infection according to their management: n/r, sotrovimab or no specific treatment.
Patients and methods: We conducted a monocentric, retrospective observational study, including KTRs diagnosed Omicron infection between January and May 1st 2022 and compared their outcome (primary outcome defined as hospital admission for COVID-19 within a month after symptoms onset) according to early COVID-19 management.
Results: Forty-five patients were included: 22 treated (12 n/r, 10 sotrovimab) and 23 with no specific treatment. The groups were statistically comparable. Two patients were admitted for COVID-19: one in each group, resulting in a non-different probability of the primary outcome at on month (p=0.9). Three patients presented tacrolimus overdose including two with acute kidney injury.
Conclusions: There was no difference in outcome according to early therapeutic management: n/r, sotrovimab or no specific treatment. Our study both underlines a decreased severity of Omicron COVID-19 in KTRs (probably related to vaccinal immunity and decreased virulence of Omicron) and a potential severe adverse effects with n/r.
{"title":"COVID-19 early curative treatments in kidney transplant recipients: is it really reasonable at the Omicron era?","authors":"Yanis Tamzali, Alexia Lundy, Alexandre Bleibtreu, Maud Cazenave, Inna Mohammadou, Nadia Arzouk, Pierre Galichon, Stéphane Marot, Helga Junot, Benoît Barrou, Valérie Pourcher, Jérôme Tourret","doi":"10.1684/ndt.2023.44","DOIUrl":"10.1684/ndt.2023.44","url":null,"abstract":"<p><strong>Objective: </strong>Data about efficacy and safety of the latest COVID-19 treatments as nirmatrelvir/ritonavir (n/r) or Sotrovimab is scarce in solid organ transplant recipients in the Omicron era. This study aims at describing the outcome of kidney transplant recipients (KTRs) presenting Omicron infection according to their management: n/r, sotrovimab or no specific treatment.</p><p><strong>Patients and methods: </strong>We conducted a monocentric, retrospective observational study, including KTRs diagnosed Omicron infection between January and May 1st 2022 and compared their outcome (primary outcome defined as hospital admission for COVID-19 within a month after symptoms onset) according to early COVID-19 management.</p><p><strong>Results: </strong>Forty-five patients were included: 22 treated (12 n/r, 10 sotrovimab) and 23 with no specific treatment. The groups were statistically comparable. Two patients were admitted for COVID-19: one in each group, resulting in a non-different probability of the primary outcome at on month (p=0.9). Three patients presented tacrolimus overdose including two with acute kidney injury.</p><p><strong>Conclusions: </strong>There was no difference in outcome according to early therapeutic management: n/r, sotrovimab or no specific treatment. Our study both underlines a decreased severity of Omicron COVID-19 in KTRs (probably related to vaccinal immunity and decreased virulence of Omicron) and a potential severe adverse effects with n/r.</p>","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"19 6","pages":"491-496"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71430600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-03Epub Date: 2023-07-17DOI: 10.1684/ndt.2023.34
Pablo Antonio Ureña Torres, Guillaume Jean
{"title":"[Arguments justifying the measurement of the most relevant biochemical parameters to monitor bone and mineral metabolism in dialysis patients].","authors":"Pablo Antonio Ureña Torres, Guillaume Jean","doi":"10.1684/ndt.2023.34","DOIUrl":"10.1684/ndt.2023.34","url":null,"abstract":"","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"19 4","pages":"293-296"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-03Epub Date: 2023-07-17DOI: 10.1684/ndt.2023.25
François Diévart, Patrice Darmon, Jean-Michel Halimi, Samy Hadjadj, Denis Angoulvant, Gaétan Prévost, Pierre Delanaye, Jean-Marc Boivin
{"title":"[How and when to use iSGLT2 (gliflozins) in clinical practice: a consensus for clinical practice proposed by the SFD, the SFC, the CNCF and the SFNDT].","authors":"François Diévart, Patrice Darmon, Jean-Michel Halimi, Samy Hadjadj, Denis Angoulvant, Gaétan Prévost, Pierre Delanaye, Jean-Marc Boivin","doi":"10.1684/ndt.2023.25","DOIUrl":"10.1684/ndt.2023.25","url":null,"abstract":"","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"19 4","pages":"251-277"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138815987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luc Frimat, François Vrtovsnik, Justine Bacchetta, Cécile Vigneau, Valérie Moal
{"title":"[New year, new publisher, new format for Néphrologie & Thérapeutique].","authors":"Luc Frimat, François Vrtovsnik, Justine Bacchetta, Cécile Vigneau, Valérie Moal","doi":"10.1684/ndt.2023.8","DOIUrl":"https://doi.org/10.1684/ndt.2023.8","url":null,"abstract":"","PeriodicalId":94153,"journal":{"name":"Nephrologie & therapeutique","volume":"19 1","pages":"5-6"},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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