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Altered regional cerebral glucose metabolism and its correlation with cognitive impairment in the subacute stage of COVID-19 新冠肺炎亚急性期局部脑糖代谢改变及其与认知功能障碍的相关性
Pub Date : 2021-04-01 DOI: 10.1055/S-0041-1726699
G. Blazhenets, A. Dreßing, N. Schroeter, T. Bormann, J. Thurow, L. Frings, C. Weiller, J. Hosp, P. Meyer
Ziel/Aim Given the rapid spread of SARS-CoV-2 and emerging evidence of neurological symptoms particularly in hospitalized COVID-19 patients, we examined the impact of COVID-19 on the CNS in inpatients at the subacute stage by F-18-FDG PET. Methodik/Methods We assessed neurological and neuropsychological symptoms (MoCA) and F-18-FDG PET scans in 15 COVID-19 inpatients (once patients were no longer infectious). All scans were visually read using a 3-step rating scale (normal, mildly and severely abnormal). Principal components analysis (PCA;avoiding the need of a currently unknown reference region) was employed to explore whether a spatial covariance pattern exists in COVID-19 (compared to 45 control patients without somatic CNS disease). Exploratory, we assessed mean normalized F-18-FDG uptake (lean body weight- and plasma glucose-adjusted standardized uptake value, SUV) in 10 % voxels with highest covariance weights (positive and negative). Ergebnisse/Results Visual reads indicated pathological results in 10/15 patients (mainly frontotemporal hypometabolism). We detected a highly significant (p .39] in 10 % voxels with most negative and positive weights, respectively). Schlussfolgerungen/Conclusions Neocortical dysfunction accompanied by cognitive impairment was detected in two-thirds of inpatients with subacute COVID-19. A clear indication of regional hypermetabolism (suggesting inflammation) was not found. Follow-up studies are currently underway.
鉴于SARS-CoV-2的快速传播和新出现的神经系统症状证据,特别是在住院的COVID-19患者中,我们通过F-18-FDG PET检测了COVID-19对亚急性期住院患者中枢神经系统的影响。方法:我们评估了15例COVID-19住院患者(一旦患者不再具有传染性)的神经和神经心理症状(MoCA)和F-18-FDG PET扫描。所有扫描结果使用3步评定量表(正常、轻度和严重异常)进行视觉读取。采用主成分分析(PCA,避免了目前未知参考区域的需要)来探讨COVID-19是否存在空间协方差模式(与45名无躯体中枢神经系统疾病的对照患者相比)。探索性地,我们评估了具有最高协方差权重(正和负)的10%体素的平均标准化F-18-FDG摄取(瘦体重和血浆葡萄糖调整的标准化摄取值,SUV)。结果10/15例患者的视觉读数显示病理结果(主要是额颞叶代谢低下)。我们在10%的体素中检测到高度显著(p .39),分别具有大多数负权重和正权重)。结论在三分之二的亚急性COVID-19住院患者中检测到新皮质功能障碍伴认知障碍。没有发现明显的局部高代谢(提示炎症)迹象。目前正在进行后续研究。
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引用次数: 0
Are radiopharmaceuticals self-sterilizing? Radiation effect of gallium-68 and lutetium-177 on bacillus pumilus and staphylococcus succinus 放射性药物能自我消毒吗?镓-68和镥-177对矮芽孢杆菌和琥珀葡萄球菌的辐射效应
Pub Date : 2021-04-01 DOI: 10.1055/s-0041-1727083
S. Poetzsch, W. Brenner, S. Spreckelmeyer
Simon Poetzsch Charite Universitatsmedizin Berlin Campus Virchow-Klinikum Winfried Brenner (  winfried.brenner@charite.de ) https://orcid.org/0000-0003-2478-6004 Sarah Spreckelmeyer Charite Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität and Berlin Institute of Health, Department of Nuclear Medicine, Augustenburger Platz 1, 13353 Berlin https://orcid.org/0000-0003-1348-0309
Simon Poetzsch Charite Universitatsmedizin Berlin校园Virchow-Klinikum Winfried Brenner (winfried.brenner@charite.de) https://orcid.org/0000-0003-2478-6004 Sarah Spreckelmeyer Charite Universitätsmedizin柏林,Freie的公司成员Universität柏林,Humboldt-Universität和柏林卫生研究所,核医学系,奥古斯丁堡广场113353柏林https://orcid.org/0000-0003-1348-0309
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引用次数: 0
Einfluss von THC auf die Glukoseaufnahme und den zellulären Energiestatus im Rattenhirn und auf die Impulskontrolle 高纯度THC对葡萄糖的输入和细胞能量的影响
Pub Date : 2021-04-01 DOI: 10.1055/S-0041-1726773
I. Miederer, N. Bausbacher, M. Baeken, J. Röhrich, K. Elsner, P. Mildenberger, P. Hajieva, B. Lutz, U. Schmitt, M. Schreckenberger
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引用次数: 0
Hypertrophie des kontralateralen Leberlappens nach SIRT mit Ho-166-Mikrospheren 睾丸素过高
Pub Date : 2021-04-01 DOI: 10.1055/S-0041-1727077
M. Heuschkel, T. Heller, J. Kurth, G. Lamprecht, S. Schwarzenböck, B. Krause
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引用次数: 0
A new horizon for breast cancer staging: first evidence from simultaneous PET-MRI targeting the fibroblast activating protein (FAP) 乳腺癌分期的新视野:同时PET-MRI靶向成纤维细胞激活蛋白(FAP)的第一个证据
Pub Date : 2021-04-01 DOI: 10.1055/S-0041-1726702
P. Backhaus, M. Burg, W. Roll, F. Büther, HJ Breyholz, SB Weigel, W. Heindel, M. Pixberg, P. Barth, J. Tio, M. Schäfers
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引用次数: 1
Kritische Überprüfung des prädiktiven Wertes der TSH-stimulierten Tg-Messung (sTg) tsh激励tg (sTg)的预测价值批判性审视
Pub Date : 2021-04-01 DOI: 10.1055/S-0041-1726795
K. Pabst, E. Gilman, M. Bröcker-Preuss, K. Herrmann, R. Görges
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引用次数: 0
Comparison of conventional gated PET and novel CardioFreeze™ motion correction (Siemens Healthineers) on calculating ejection fraction in cardiac PET/CT 传统门控PET与新型cardifreeze™运动校正(Siemens Healthineers)在心脏PET/CT中计算射血分数的比较
Pub Date : 2021-04-01 DOI: 10.1055/S-0041-1726732
R. Zabel, R. Preuß, W. Burchert
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引用次数: 0
Population-Based Model Selection Algorithm developed at the example of Lu-177-PSMA Therapy 以Lu-177-PSMA治疗为例开发的基于群体的模型选择算法
Pub Date : 2021-04-01 DOI: 10.1055/S-0041-1726785
D. Hardiansyah, A. Riana, P. Kletting, N. Zaid, A. Beer, G. Glatting
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引用次数: 0
Gallium-68-CXCR4-PET/CT chemokine receptor-targeting imaging in acute SARS-Cov-2 infection: a case report 镓-68- cxcr4 - pet /CT趋化因子受体靶向显像在急性SARS-Cov-2感染中的应用
Pub Date : 2021-04-01 DOI: 10.1055/S-0041-1726735
A. Lambertini, P. Hartrampf, S. Serfling, P. Meybohm, A. Schirbel, A. Buck
Ziel/Aim Single-patient report on the pattern of CXCR4 expression in a patient presenting with acute respiratory SARS-Cov-2 (COVID-19) infection after hybrid imaging with Ga-68-pentixafor-PET/non-ceCT (CXCR4-PET). Methodik/Methods 37-year-old man presenting with pneumonia, severe ARDS, requiring mechanical ventilation and acute supportive therapy. Later diagnose of bacterial superinfection with septic shock, persistent high fever (>40 °C) and elevated inflammation markers, non-responsive to wide-spectrum antibiotics. 178 MBq of Ga-68-pentixafor then administered in accordance with the responsible regulatory body after obtaining informed consent. Whole-body imaging followed on a dedicated PET-scanner 1h post-injection. Low-dose CT scans for attenuation correction were acquired (top of the skull to proximal tibias). Ergebnisse/Results CRCX4-PET showed only faint pulmonary uptake in parallel with significantly enhanced, diffuse tracer-uptake in the bone marrow (spine, thorax and pelvis) as well as in the spleen. Increased CXCR4-expression in the pharyngeal/palatine tonsils, CXCR4-positive lymph nodes in the neck/thorax as well as abdominal/inguinal regions was also reported. Focal soft-tissue uptake was detected in the distal right thigh, showing a characteristic peripheral tracer distribution strongly suggestive of intramuscular inflammatory focus. Schlussfolgerungen/Conclusions Ga-68-pentixafor-PET/low-dose-CT hybrid imaging showed foci of increased CXCR4-expression other than the lungs in a SARS-Cov-2 patient presenting with persistent high fever. Although lacking validation data, this single case suggests a role of CXCR4-targeted hybrid imaging in acute inflammatory conditions such as COVID-19 infections and warrants further prospective studies to evaluate its potential role in guiding clinical management in a more complex setting of systemic, multi-organ infectious/inflammatory disease.
用ga -68- pentxa for pet /non-ceCT (CXCR4- pet)混合成像后急性呼吸道SARS-Cov-2 (COVID-19)感染患者中CXCR4表达模式的单例报告。方法37岁男性,临床表现为肺炎,严重急性呼吸窘迫综合征,需要机械通气和急性支持治疗。后来诊断为细菌性重复感染并脓毒性休克,持续高热(bbb40°C)和炎症标志物升高,对广谱抗生素无反应。在获得知情同意后,按照负责监管机构的规定,对178 MBq的ga -68- pentxafor进行管理。注射后1h在专用pet扫描仪上进行全身成像。低剂量CT扫描用于衰减校正(颅骨顶部至胫骨近端)。结果CRCX4-PET仅显示微弱的肺部摄取,同时骨髓(脊柱、胸腔和骨盆)以及脾脏的弥漫性示踪剂摄取显著增强。咽部/腭扁桃体中cxcr4表达增加,颈部/胸部以及腹部/腹股沟区域的cxcr4阳性淋巴结也有报道。在右大腿远端检测到局灶性软组织摄取,表现出强烈提示肌内炎症灶的特征性外周示踪剂分布。ga -68-pentixa - pet /低剂量ct混合成像显示,在持续高热的SARS-Cov-2患者中,除肺部外,还有cxcr4表达升高的病灶。尽管缺乏验证数据,但这一单一病例表明,cxcr4靶向混合成像在COVID-19感染等急性炎症条件下的作用,值得进一步的前瞻性研究,以评估其在更复杂的全身性、多器官感染性/炎症性疾病的指导临床管理中的潜在作用。
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引用次数: 0
PSMA- and FDG-PET mismatch assessment for optimized selection of PSMA radioligand therapy candidates PSMA与FDG-PET失配评估,以优化PSMA放射配体治疗候选者的选择
Pub Date : 2021-04-01 DOI: 10.1055/S-0041-1726862
P. Sandach, D. Kersting, M. Weber, J. Ferdinandus, A. Wetter, M. Spanke, M. Nader, C. Kesch, B. Hadaschik, K. Herrmann, W. Fendler, R. Seifert
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引用次数: 2
期刊
Nuklearmedizin. Nuclear medicine
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