G. Blazhenets, A. Dreßing, N. Schroeter, T. Bormann, J. Thurow, L. Frings, C. Weiller, J. Hosp, P. Meyer
Ziel/Aim Given the rapid spread of SARS-CoV-2 and emerging evidence of neurological symptoms particularly in hospitalized COVID-19 patients, we examined the impact of COVID-19 on the CNS in inpatients at the subacute stage by F-18-FDG PET. Methodik/Methods We assessed neurological and neuropsychological symptoms (MoCA) and F-18-FDG PET scans in 15 COVID-19 inpatients (once patients were no longer infectious). All scans were visually read using a 3-step rating scale (normal, mildly and severely abnormal). Principal components analysis (PCA;avoiding the need of a currently unknown reference region) was employed to explore whether a spatial covariance pattern exists in COVID-19 (compared to 45 control patients without somatic CNS disease). Exploratory, we assessed mean normalized F-18-FDG uptake (lean body weight- and plasma glucose-adjusted standardized uptake value, SUV) in 10 % voxels with highest covariance weights (positive and negative). Ergebnisse/Results Visual reads indicated pathological results in 10/15 patients (mainly frontotemporal hypometabolism). We detected a highly significant (p .39] in 10 % voxels with most negative and positive weights, respectively). Schlussfolgerungen/Conclusions Neocortical dysfunction accompanied by cognitive impairment was detected in two-thirds of inpatients with subacute COVID-19. A clear indication of regional hypermetabolism (suggesting inflammation) was not found. Follow-up studies are currently underway.
{"title":"Altered regional cerebral glucose metabolism and its correlation with cognitive impairment in the subacute stage of COVID-19","authors":"G. Blazhenets, A. Dreßing, N. Schroeter, T. Bormann, J. Thurow, L. Frings, C. Weiller, J. Hosp, P. Meyer","doi":"10.1055/S-0041-1726699","DOIUrl":"https://doi.org/10.1055/S-0041-1726699","url":null,"abstract":"Ziel/Aim Given the rapid spread of SARS-CoV-2 and emerging evidence of neurological symptoms particularly in hospitalized COVID-19 patients, we examined the impact of COVID-19 on the CNS in inpatients at the subacute stage by F-18-FDG PET. Methodik/Methods We assessed neurological and neuropsychological symptoms (MoCA) and F-18-FDG PET scans in 15 COVID-19 inpatients (once patients were no longer infectious). All scans were visually read using a 3-step rating scale (normal, mildly and severely abnormal). Principal components analysis (PCA;avoiding the need of a currently unknown reference region) was employed to explore whether a spatial covariance pattern exists in COVID-19 (compared to 45 control patients without somatic CNS disease). Exploratory, we assessed mean normalized F-18-FDG uptake (lean body weight- and plasma glucose-adjusted standardized uptake value, SUV) in 10 % voxels with highest covariance weights (positive and negative). Ergebnisse/Results Visual reads indicated pathological results in 10/15 patients (mainly frontotemporal hypometabolism). We detected a highly significant (p .39] in 10 % voxels with most negative and positive weights, respectively). Schlussfolgerungen/Conclusions Neocortical dysfunction accompanied by cognitive impairment was detected in two-thirds of inpatients with subacute COVID-19. A clear indication of regional hypermetabolism (suggesting inflammation) was not found. Follow-up studies are currently underway.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"6 1","pages":"131"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79615055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simon Poetzsch Charite Universitatsmedizin Berlin Campus Virchow-Klinikum Winfried Brenner ( winfried.brenner@charite.de ) https://orcid.org/0000-0003-2478-6004 Sarah Spreckelmeyer Charite Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität and Berlin Institute of Health, Department of Nuclear Medicine, Augustenburger Platz 1, 13353 Berlin https://orcid.org/0000-0003-1348-0309
Simon Poetzsch Charite Universitatsmedizin Berlin校园Virchow-Klinikum Winfried Brenner (winfried.brenner@charite.de) https://orcid.org/0000-0003-2478-6004 Sarah Spreckelmeyer Charite Universitätsmedizin柏林，Freie的公司成员Universität柏林，Humboldt-Universität和柏林卫生研究所，核医学系，奥古斯丁堡广场113353柏林https://orcid.org/0000-0003-1348-0309
{"title":"Are radiopharmaceuticals self-sterilizing? Radiation effect of gallium-68 and lutetium-177 on bacillus pumilus and staphylococcus succinus","authors":"S. Poetzsch, W. Brenner, S. Spreckelmeyer","doi":"10.1055/s-0041-1727083","DOIUrl":"https://doi.org/10.1055/s-0041-1727083","url":null,"abstract":"Simon Poetzsch Charite Universitatsmedizin Berlin Campus Virchow-Klinikum Winfried Brenner ( winfried.brenner@charite.de ) https://orcid.org/0000-0003-2478-6004 Sarah Spreckelmeyer Charite Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität and Berlin Institute of Health, Department of Nuclear Medicine, Augustenburger Platz 1, 13353 Berlin https://orcid.org/0000-0003-1348-0309","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"17 1","pages":"189"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83436882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Miederer, N. Bausbacher, M. Baeken, J. Röhrich, K. Elsner, P. Mildenberger, P. Hajieva, B. Lutz, U. Schmitt, M. Schreckenberger
{"title":"Einfluss von THC auf die Glukoseaufnahme und den zellulären Energiestatus im Rattenhirn und auf die Impulskontrolle","authors":"I. Miederer, N. Bausbacher, M. Baeken, J. Röhrich, K. Elsner, P. Mildenberger, P. Hajieva, B. Lutz, U. Schmitt, M. Schreckenberger","doi":"10.1055/S-0041-1726773","DOIUrl":"https://doi.org/10.1055/S-0041-1726773","url":null,"abstract":"","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"30 1","pages":"168"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80812958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Heuschkel, T. Heller, J. Kurth, G. Lamprecht, S. Schwarzenböck, B. Krause
{"title":"Hypertrophie des kontralateralen Leberlappens nach SIRT mit Ho-166-Mikrospheren","authors":"M. Heuschkel, T. Heller, J. Kurth, G. Lamprecht, S. Schwarzenböck, B. Krause","doi":"10.1055/S-0041-1727077","DOIUrl":"https://doi.org/10.1055/S-0041-1727077","url":null,"abstract":"","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"1 1","pages":"187"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74537394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Backhaus, M. Burg, W. Roll, F. Büther, HJ Breyholz, SB Weigel, W. Heindel, M. Pixberg, P. Barth, J. Tio, M. Schäfers
{"title":"A new horizon for breast cancer staging: first evidence from simultaneous PET-MRI targeting the fibroblast activating protein (FAP)","authors":"P. Backhaus, M. Burg, W. Roll, F. Büther, HJ Breyholz, SB Weigel, W. Heindel, M. Pixberg, P. Barth, J. Tio, M. Schäfers","doi":"10.1055/S-0041-1726702","DOIUrl":"https://doi.org/10.1055/S-0041-1726702","url":null,"abstract":"","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"33 1","pages":"132"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73613661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Pabst, E. Gilman, M. Bröcker-Preuss, K. Herrmann, R. Görges
{"title":"Kritische Überprüfung des prädiktiven Wertes der TSH-stimulierten Tg-Messung (sTg)","authors":"K. Pabst, E. Gilman, M. Bröcker-Preuss, K. Herrmann, R. Görges","doi":"10.1055/S-0041-1726795","DOIUrl":"https://doi.org/10.1055/S-0041-1726795","url":null,"abstract":"","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"51 1","pages":"137 - 138"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73637526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of conventional gated PET and novel CardioFreeze™ motion correction (Siemens Healthineers) on calculating ejection fraction in cardiac PET/CT","authors":"R. Zabel, R. Preuß, W. Burchert","doi":"10.1055/S-0041-1726732","DOIUrl":"https://doi.org/10.1055/S-0041-1726732","url":null,"abstract":"","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"8 1","pages":"158"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84240163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Hardiansyah, A. Riana, P. Kletting, N. Zaid, A. Beer, G. Glatting
{"title":"Population-Based Model Selection Algorithm developed at the example of Lu-177-PSMA Therapy","authors":"D. Hardiansyah, A. Riana, P. Kletting, N. Zaid, A. Beer, G. Glatting","doi":"10.1055/S-0041-1726785","DOIUrl":"https://doi.org/10.1055/S-0041-1726785","url":null,"abstract":"","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"11 1","pages":"159"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82055744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Lambertini, P. Hartrampf, S. Serfling, P. Meybohm, A. Schirbel, A. Buck
Ziel/Aim Single-patient report on the pattern of CXCR4 expression in a patient presenting with acute respiratory SARS-Cov-2 (COVID-19) infection after hybrid imaging with Ga-68-pentixafor-PET/non-ceCT (CXCR4-PET). Methodik/Methods 37-year-old man presenting with pneumonia, severe ARDS, requiring mechanical ventilation and acute supportive therapy. Later diagnose of bacterial superinfection with septic shock, persistent high fever (>40 °C) and elevated inflammation markers, non-responsive to wide-spectrum antibiotics. 178 MBq of Ga-68-pentixafor then administered in accordance with the responsible regulatory body after obtaining informed consent. Whole-body imaging followed on a dedicated PET-scanner 1h post-injection. Low-dose CT scans for attenuation correction were acquired (top of the skull to proximal tibias). Ergebnisse/Results CRCX4-PET showed only faint pulmonary uptake in parallel with significantly enhanced, diffuse tracer-uptake in the bone marrow (spine, thorax and pelvis) as well as in the spleen. Increased CXCR4-expression in the pharyngeal/palatine tonsils, CXCR4-positive lymph nodes in the neck/thorax as well as abdominal/inguinal regions was also reported. Focal soft-tissue uptake was detected in the distal right thigh, showing a characteristic peripheral tracer distribution strongly suggestive of intramuscular inflammatory focus. Schlussfolgerungen/Conclusions Ga-68-pentixafor-PET/low-dose-CT hybrid imaging showed foci of increased CXCR4-expression other than the lungs in a SARS-Cov-2 patient presenting with persistent high fever. Although lacking validation data, this single case suggests a role of CXCR4-targeted hybrid imaging in acute inflammatory conditions such as COVID-19 infections and warrants further prospective studies to evaluate its potential role in guiding clinical management in a more complex setting of systemic, multi-organ infectious/inflammatory disease.
用ga -68- pentxa for pet /non-ceCT (CXCR4- pet)混合成像后急性呼吸道SARS-Cov-2 (COVID-19)感染患者中CXCR4表达模式的单例报告。方法37岁男性，临床表现为肺炎，严重急性呼吸窘迫综合征，需要机械通气和急性支持治疗。后来诊断为细菌性重复感染并脓毒性休克，持续高热(bbb40°C)和炎症标志物升高，对广谱抗生素无反应。在获得知情同意后，按照负责监管机构的规定，对178 MBq的ga -68- pentxafor进行管理。注射后1h在专用pet扫描仪上进行全身成像。低剂量CT扫描用于衰减校正(颅骨顶部至胫骨近端)。结果CRCX4-PET仅显示微弱的肺部摄取，同时骨髓(脊柱、胸腔和骨盆)以及脾脏的弥漫性示踪剂摄取显著增强。咽部/腭扁桃体中cxcr4表达增加，颈部/胸部以及腹部/腹股沟区域的cxcr4阳性淋巴结也有报道。在右大腿远端检测到局灶性软组织摄取，表现出强烈提示肌内炎症灶的特征性外周示踪剂分布。ga -68-pentixa - pet /低剂量ct混合成像显示，在持续高热的SARS-Cov-2患者中，除肺部外，还有cxcr4表达升高的病灶。尽管缺乏验证数据，但这一单一病例表明，cxcr4靶向混合成像在COVID-19感染等急性炎症条件下的作用，值得进一步的前瞻性研究，以评估其在更复杂的全身性、多器官感染性/炎症性疾病的指导临床管理中的潜在作用。
{"title":"Gallium-68-CXCR4-PET/CT chemokine receptor-targeting imaging in acute SARS-Cov-2 infection: a case report","authors":"A. Lambertini, P. Hartrampf, S. Serfling, P. Meybohm, A. Schirbel, A. Buck","doi":"10.1055/S-0041-1726735","DOIUrl":"https://doi.org/10.1055/S-0041-1726735","url":null,"abstract":"Ziel/Aim Single-patient report on the pattern of CXCR4 expression in a patient presenting with acute respiratory SARS-Cov-2 (COVID-19) infection after hybrid imaging with Ga-68-pentixafor-PET/non-ceCT (CXCR4-PET). Methodik/Methods 37-year-old man presenting with pneumonia, severe ARDS, requiring mechanical ventilation and acute supportive therapy. Later diagnose of bacterial superinfection with septic shock, persistent high fever (>40 °C) and elevated inflammation markers, non-responsive to wide-spectrum antibiotics. 178 MBq of Ga-68-pentixafor then administered in accordance with the responsible regulatory body after obtaining informed consent. Whole-body imaging followed on a dedicated PET-scanner 1h post-injection. Low-dose CT scans for attenuation correction were acquired (top of the skull to proximal tibias). Ergebnisse/Results CRCX4-PET showed only faint pulmonary uptake in parallel with significantly enhanced, diffuse tracer-uptake in the bone marrow (spine, thorax and pelvis) as well as in the spleen. Increased CXCR4-expression in the pharyngeal/palatine tonsils, CXCR4-positive lymph nodes in the neck/thorax as well as abdominal/inguinal regions was also reported. Focal soft-tissue uptake was detected in the distal right thigh, showing a characteristic peripheral tracer distribution strongly suggestive of intramuscular inflammatory focus. Schlussfolgerungen/Conclusions Ga-68-pentixafor-PET/low-dose-CT hybrid imaging showed foci of increased CXCR4-expression other than the lungs in a SARS-Cov-2 patient presenting with persistent high fever. Although lacking validation data, this single case suggests a role of CXCR4-targeted hybrid imaging in acute inflammatory conditions such as COVID-19 infections and warrants further prospective studies to evaluate its potential role in guiding clinical management in a more complex setting of systemic, multi-organ infectious/inflammatory disease.","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"120 1","pages":"159"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79465637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Sandach, D. Kersting, M. Weber, J. Ferdinandus, A. Wetter, M. Spanke, M. Nader, C. Kesch, B. Hadaschik, K. Herrmann, W. Fendler, R. Seifert
{"title":"PSMA- and FDG-PET mismatch assessment for optimized selection of PSMA radioligand therapy candidates","authors":"P. Sandach, D. Kersting, M. Weber, J. Ferdinandus, A. Wetter, M. Spanke, M. Nader, C. Kesch, B. Hadaschik, K. Herrmann, W. Fendler, R. Seifert","doi":"10.1055/S-0041-1726862","DOIUrl":"https://doi.org/10.1055/S-0041-1726862","url":null,"abstract":"","PeriodicalId":94161,"journal":{"name":"Nuklearmedizin. Nuclear medicine","volume":"16 1","pages":"184"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84348120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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