Pub Date : 2026-03-01Epub Date: 2026-02-17DOI: 10.1016/j.resplu.2026.101275
Katherine S. Allan , Holly McCulloch , Kim Ruether , Jeanine Zotzman , Ian E. Blanchard , Michael Janczyszyn , Natalie Wong , Emma O’Neil , John Sapp , Santokh Dhillon
Background
There are multiple models to train school students to provide effective cardiopulmonary resuscitation (CPR) and apply automatic external defibrillator (AED). However, few have assessed gamified, video-based training to teach school children. This national project aimed to assess the acceptability and effectiveness of a video-based, gamified educational program (CardiacCrash™), to teach students in classroom setting, how to respond to a cardiac arrest.
Methods
This interrupted time series study assessed students’ acceptability of the program, their perceived confidence in responding to cardiac arrest and their effectiveness at performing CPR. Paper-based surveys administered before and after the educational sessions. CPR performance (rate, depth) for students was measured quantitatively using Laerdal Resusci Anne QCPR manikins.
Results
A total of 1958 students from 21 schools in three Canadian provinces participated between October 2023 and June 2024 (average age of 13 ± 2.4 years). About 49.7% (969) were male and 54.8% were secondary school students. About 42.3% had prior CPR training. Students reported: the program was easy to understand (83.5%), fun (90.2%), the right length (72.0%), and they would recommend to friends (88.9%). The self-confidence of all school students increased significantly in all outcome measures post-training, particularly in those without prior CPR training. All students achieved appropriate CPR depth and rate, as per guidelines; however, secondary students were significantly better at providing effective compressions compared to elementary students.
Conclusion
A novel, gamified, video-based, educational program is acceptable to school-aged children and appears effective at teaching them CPR and AED usage.
培养学生进行有效的心肺复苏(CPR)和应用自动体外除颤器(AED)的模式多种多样。然而,很少有人评估过以游戏化、视频为基础的培训来教育学生。这个国家项目旨在评估一个基于视频的游戏化教育项目(cardiacrash™)的可接受性和有效性,该项目在课堂上教授学生如何应对心脏骤停。方法:这项中断时间序列研究评估了学生对该计划的接受程度,他们对心脏骤停反应的感知信心以及实施心肺复苏术的有效性。在教育课程之前和之后进行的纸质调查。使用Laerdal Resusci Anne QCPR人体模型定量测量学生的心肺复苏术表现(速率、深度)。结果在2023年10月至2024年6月期间,共有来自加拿大3省21所学校的1958名学生参与调查,平均年龄13±2.4岁。约49.7%(969人)为男性,54.8%为中学生。约42.3%曾接受过心肺复苏术培训。学生们反映:该课程容易理解(83.5%),有趣(90.2%),长度合适(72.0%),他们会推荐给朋友(88.9%)。在训练后的所有结果测量中,所有学生的自信心都显著增加,尤其是那些没有接受过心肺复苏术训练的学生。根据指导方针,所有学生都达到了适当的心肺复苏深度和速度;然而,中学生在提供有效压缩方面明显优于小学生。结论一种新颖的、游戏化的、基于视频的教育节目对学龄儿童是可接受的,并能有效地教授他们CPR和AED的使用。
{"title":"Acceptability and effectiveness of training elementary and secondary students in gamified CPR and AED use in three Canadian provinces","authors":"Katherine S. Allan , Holly McCulloch , Kim Ruether , Jeanine Zotzman , Ian E. Blanchard , Michael Janczyszyn , Natalie Wong , Emma O’Neil , John Sapp , Santokh Dhillon","doi":"10.1016/j.resplu.2026.101275","DOIUrl":"10.1016/j.resplu.2026.101275","url":null,"abstract":"<div><h3>Background</h3><div>There are multiple models to train school students to provide effective cardiopulmonary resuscitation (CPR) and apply automatic external defibrillator (AED). However, few have assessed gamified, video-based training to teach school children. This national project aimed to assess the acceptability and effectiveness of a video-based, gamified educational program (CardiacCrash™), to teach students in classroom setting, how to respond to a cardiac arrest.</div></div><div><h3>Methods</h3><div>This interrupted time series study assessed students’ acceptability of the program, their perceived confidence in responding to cardiac arrest and their effectiveness at performing CPR. Paper-based surveys administered before and after the educational sessions. CPR performance (rate, depth) for students was measured quantitatively using Laerdal Resusci Anne QCPR manikins.</div></div><div><h3>Results</h3><div>A total of 1958 students from 21 schools in three Canadian provinces participated between October 2023 and June 2024 (average age of 13 ± 2.4 years). About 49.7% (969) were male and 54.8% were secondary school students. About 42.3% had prior CPR training. Students reported: the program was easy to understand (83.5%), fun (90.2%), the right length (72.0%), and they would recommend to friends (88.9%). The self-confidence of all school students increased significantly in all outcome measures post-training, particularly in those without prior CPR training. All students achieved appropriate CPR depth and rate, as per guidelines; however, secondary students were significantly better at providing effective compressions compared to elementary students.</div></div><div><h3>Conclusion</h3><div>A novel, gamified, video-based, educational program is acceptable to school-aged children and appears effective at teaching them CPR and AED usage.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"28 ","pages":"Article 101275"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147421674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-02-19DOI: 10.1016/j.resplu.2026.101279
Alejandro Romero-Linares , Francisco M. Parrilla-Ruiz , Gerardo Gómez-Moreno , Ana Carrasco-Cáliz , Antonio Cárdenas-Cruz
Background and aim
Early bystander intervention is a key determinant of survival after out-of-hospital cardiac arrest, and school-based cardiopulmonary resuscitation (CPR) training is widely recommended to strengthen community response. However, evidence on medium-term retention of procedural skills and on the diffusion of basic life support (BLS) knowledge from trained students to their household environment remains limited. The aim of this study was to assess medium-term retention of procedural BLS competencies in schoolchildren following a structured educational intervention, and to evaluate the diffusion of BLS knowledge and perceived capacity to act to family members.
Methods
This study evaluated students from primary, secondary, and high school and a voluntary subsample of family members in a school in Granada (Spain). Sociodemographic characteristics and cognitive and attitudinal variables were collected using an anonymized online questionnaire. Procedural basic life support (BLS) competencies were assessed approximately four months after the educational intervention through face-to-face simulation using a structured rubric applied by external evaluators trained in BLS. Household diffusion was evaluated through family-reported outcomes, including discussion of the training experience at home and perceived capacity to act in an emergency.
Results
The intervention included 683 students and 196 family members. At medium-term follow-up, students showed high procedural performance in key BLS actions, including high rates of adequate chest compression quality (89.3%), correct AED pad placement (81.8%), and safe shock delivery (91.9%). Household diffusion was substantial, with most relatives reporting discussion of the training experience at home and approximately half reporting active teaching attempts by the student. Relatives’ perceived capacity to act increased markedly.
Conclusion
A structured, school-wide BLS intervention delivered in the school setting supports sustained procedural competence in schoolchildren and facilitates meaningful diffusion of resuscitation knowledge and confidence to the household environment. These findings reinforce the role of schools as strategic platforms for scalable interventions aimed at strengthening community preparedness for out-of-hospital cardiac arrest.
{"title":"Medium-term retention and household diffusion of basic life support skills after a school-wide educational intervention: PLANIFICARCP PROJECT","authors":"Alejandro Romero-Linares , Francisco M. Parrilla-Ruiz , Gerardo Gómez-Moreno , Ana Carrasco-Cáliz , Antonio Cárdenas-Cruz","doi":"10.1016/j.resplu.2026.101279","DOIUrl":"10.1016/j.resplu.2026.101279","url":null,"abstract":"<div><h3>Background and aim</h3><div>Early bystander intervention is a key determinant of survival after out-of-hospital cardiac arrest, and school-based cardiopulmonary resuscitation (CPR) training is widely recommended to strengthen community response. However, evidence on medium-term retention of procedural skills and on the diffusion of basic life support (BLS) knowledge from trained students to their household environment remains limited. The aim of this study was to assess medium-term retention of procedural BLS competencies in schoolchildren following a structured educational intervention, and to evaluate the diffusion of BLS knowledge and perceived capacity to act to family members.</div></div><div><h3>Methods</h3><div>This study evaluated students from primary, secondary, and high school and a voluntary subsample of family members in a school in Granada (Spain). Sociodemographic characteristics and cognitive and attitudinal variables were collected using an anonymized online questionnaire. Procedural basic life support (BLS) competencies were assessed approximately four months after the educational intervention through face-to-face simulation using a structured rubric applied by external evaluators trained in BLS. Household diffusion was evaluated through family-reported outcomes, including discussion of the training experience at home and perceived capacity to act in an emergency.</div></div><div><h3>Results</h3><div>The intervention included 683 students and 196 family members. At medium-term follow-up, students showed high procedural performance in key BLS actions, including high rates of adequate chest compression quality (89.3%), correct AED pad placement (81.8%), and safe shock delivery (91.9%). Household diffusion was substantial, with most relatives reporting discussion of the training experience at home and approximately half reporting active teaching attempts by the student. Relatives’ perceived capacity to act increased markedly.</div></div><div><h3>Conclusion</h3><div>A structured, school-wide BLS intervention delivered in the school setting supports sustained procedural competence in schoolchildren and facilitates meaningful diffusion of resuscitation knowledge and confidence to the household environment. These findings reinforce the role of schools as strategic platforms for scalable interventions aimed at strengthening community preparedness for out-of-hospital cardiac arrest.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"28 ","pages":"Article 101279"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147421750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-18DOI: 10.1016/j.resplu.2026.101236
Ryan A. Coute , J.D. Strickland , Jolanda L. Hudson , William C. Ferguson , Benjamin Von Schweinitz , Elizabeth A. Jackson , Michael C. Kurz
Background
The bystander CPR (CPR) rate in Birmingham, Alabama is just 15.5%, contributing to one of the lowest out-of-hospital cardiac arrest (OHCA) survival rates in the United States. The utilization of telecommunicator CPR (T-CPR) in Birmingham is unknown. We aimed to evaluate existing T-CPR performance and compare local metrics to recently published American Heart Association (AHA) T-CPR guidelines.
Methods
We retrospectively reviewed all 9-1-1 audio recordings for adult (≥18 years) non-traumatic Emergency Medical Services (EMS)-treated OHCA in Birmingham during 2023. EMS-witnessed events or those occurring within healthcare or correctional facilities were excluded. T-CPR metrics were manually extracted and compared to the AHA T-CPR benchmarks using descriptive statistics.
Results
Among 236 included OHCA cases, 94 (39.8%) were correctly recognized by telecommunicators (AHA goal: >75%). Of cases recognizable by AHA definitions, 50.0% were identified correctly by telecommunicators (AHA goal: >95%), with a median recognition time of 60 s (AHA goal: <90 s). T-CPR instructions were provided to 72.7% of recognizable cases (AHA goal: >75%), with a median time to first chest compression of 172 s (AHA goal: <150 s). When T-CPR instructions were offered to callers who were willing and able to perform CPR, chest compressions were initiated in 97.9% of cases.
Conclusion
Despite low rates of telecommunicator recognition of OHCA and T-CPR instruction in Birmingham, nearly all callers who received T-CPR instructions began chest compressions. Targeted improvements in T-CPR implementation represent a high-impact opportunity to increase CPR rates in Birmingham and other communities with low bystander engagement.
{"title":"Telecommunicator cardiopulmonary resuscitation performance metrics and barriers to implementation in Birmingham, Alabama","authors":"Ryan A. Coute , J.D. Strickland , Jolanda L. Hudson , William C. Ferguson , Benjamin Von Schweinitz , Elizabeth A. Jackson , Michael C. Kurz","doi":"10.1016/j.resplu.2026.101236","DOIUrl":"10.1016/j.resplu.2026.101236","url":null,"abstract":"<div><h3>Background</h3><div>The bystander CPR (CPR) rate in Birmingham, Alabama is just 15.5%, contributing to one of the lowest out-of-hospital cardiac arrest (OHCA) survival rates in the United States. The utilization of telecommunicator CPR (T-CPR) in Birmingham is unknown. We aimed to evaluate existing T-CPR performance and compare local metrics to recently published American Heart Association (AHA) T-CPR guidelines.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed all 9-1-1 audio recordings for adult (≥18 years) non-traumatic Emergency Medical Services (EMS)-treated OHCA in Birmingham during 2023. EMS-witnessed events or those occurring within healthcare or correctional facilities were excluded. T-CPR metrics were manually extracted and compared to the AHA T-CPR benchmarks using descriptive statistics.</div></div><div><h3>Results</h3><div>Among 236 included OHCA cases, 94 (39.8%) were correctly recognized by telecommunicators (AHA goal: >75%). Of cases recognizable by AHA definitions, 50.0% were identified correctly by telecommunicators (AHA goal: >95%), with a median recognition time of 60 s (AHA goal: <90 s). T-CPR instructions were provided to 72.7% of recognizable cases (AHA goal: >75%), with a median time to first chest compression of 172 s (AHA goal: <150 s). When T-CPR instructions were offered to callers who were willing and able to perform CPR, chest compressions were initiated in 97.9% of cases.</div></div><div><h3>Conclusion</h3><div>Despite low rates of telecommunicator recognition of OHCA and T-CPR instruction in Birmingham, nearly all callers who received T-CPR instructions began chest compressions. Targeted improvements in T-CPR implementation represent a high-impact opportunity to increase CPR rates in Birmingham and other communities with low bystander engagement.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"28 ","pages":"Article 101236"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-07DOI: 10.1016/j.resplu.2026.101222
Aticha Amie Prasongsukarn , Valerie Mok , Jane Hsu , Jacob Hutton , Frank Scheuermeyer , Emad Awad , Jessica Moe , Chris Cartwright , Rohan Hundal , Sandra Jenneson , Jim Christenson , Brian Grunau
Background
Non-prescription drug toxicity accounts for up to 10% of out-of-hospital cardiac arrests (OHCAs). Bystander cardiopulmonary resuscitation (CPR) improves OHCA outcomes but may be influenced by the patient’s sex and the bystander’s perceptions of non-prescription drug use. We examined differences in bystander CPR for OHCA of female and male cases with evidence of recent non-prescription drug use.
Methods
We used the BC Cardiac Arrest Registry to identify emergency medical system-treated non-traumatic adult OHCAs (2019–2024) with evidence of recent non-prescription drug use. We assessed the association between patient sex and the primary outcome of bystander CPR, and secondary outcomes of bystander naloxone administration, automated external defibrillator (AED) application, and CPR technique, using multivariable logistic regression.
Results
Among 3012 included cases, the median age was 40 years (Quartile 1 = 31, Quartile 3 = 50) and 826 (27%) were female. Female sex (compared to male) was associated with a higher odds of receiving bystander CPR (adjusted odds ratio [aOR] 1.2; 95% CI: 1.0–1.5). Female sex was not associated with bystander naloxone administration (aOR 1.0; 95% CI: 0.81–1.3) or AED application (aOR 0.82; 95% CI: 0.48–1.4). Female sex was associated with a higher odds of receiving compression-plus-ventilation CPR versus compression-only CPR (aOR 1.8; 95% CI: 1.0–3.0), although CPR type was frequently not noted.
Conclusion
In OHCA cases with evidence of recent non-prescription drug use, female sex was associated with a higher odds of receiving bystander CPR and compression-plus-ventilation CPR. We did not detect an association between sex and bystander naloxone or AED application.
{"title":"Sex-based disparities in bystander CPR for out-of-hospital cardiac arrest related to non-prescription drug use","authors":"Aticha Amie Prasongsukarn , Valerie Mok , Jane Hsu , Jacob Hutton , Frank Scheuermeyer , Emad Awad , Jessica Moe , Chris Cartwright , Rohan Hundal , Sandra Jenneson , Jim Christenson , Brian Grunau","doi":"10.1016/j.resplu.2026.101222","DOIUrl":"10.1016/j.resplu.2026.101222","url":null,"abstract":"<div><h3>Background</h3><div>Non-prescription drug toxicity accounts for up to 10% of out-of-hospital cardiac arrests (OHCAs). Bystander cardiopulmonary resuscitation (CPR) improves OHCA outcomes but may be influenced by the patient’s sex and the bystander’s perceptions of non-prescription drug use. We examined differences in bystander CPR for OHCA of female and male cases with evidence of recent non-prescription drug use.</div></div><div><h3>Methods</h3><div>We used the BC Cardiac Arrest Registry to identify emergency medical system-treated non-traumatic adult OHCAs (2019–2024) with evidence of recent non-prescription drug use. We assessed the association between patient sex and the primary outcome of bystander CPR, and secondary outcomes of bystander naloxone administration, automated external defibrillator (AED) application, and CPR technique, using multivariable logistic regression.</div></div><div><h3>Results</h3><div>Among 3012 included cases, the median age was 40 years (Quartile 1 = 31, Quartile 3 = 50) and 826 (27%) were female. Female sex (compared to male) was associated with a higher odds of receiving bystander CPR (adjusted odds ratio [aOR] 1.2; 95% CI: 1.0–1.5). Female sex was not associated with bystander naloxone administration (aOR 1.0; 95% CI: 0.81–1.3) or AED application (aOR 0.82; 95% CI: 0.48–1.4). Female sex was associated with a higher odds of receiving compression-plus-ventilation CPR versus compression-only CPR (aOR 1.8; 95% CI: 1.0–3.0), although CPR type was frequently not noted.</div></div><div><h3>Conclusion</h3><div>In OHCA cases with evidence of recent non-prescription drug use, female sex was associated with a higher odds of receiving bystander CPR and compression-plus-ventilation CPR. We did not detect an association between sex and bystander naloxone or AED application.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"28 ","pages":"Article 101222"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-04DOI: 10.1016/j.resplu.2025.101211
Nura Khattab , Noah Zweig , Mahvareh Ahghari , Luis Da Luz , Melissa McGowan , Michael Peddle , Harley Meirovich , Aditi Khandelwal , Yulia Lin , Brodie Nolan
Background
Out-of-hospital blood transfusion (OHBT) is an emerging practice for the management of hemorrhagic shock following trauma. The Canadian Prehospital and Transport Transfusion (CAN-PATT) network aims to standardize OHBT practices and assess the feasibility of linking out-of-hospital care with in-hospital outcomes through a national registry.
Methods
This was a retrospective cohort study of patients who received OHBT through an air ambulance program between September 2021 and July 2024 and were transported to one of two regional trauma centers. Prehospital data from the air ambulance database were linked using indirect identifiers to hospital data from the trauma registries and manually reviewed charts. The primary outcome was the percentage of prehospital and in-hospital records that could be successfully linked. Continuous variables were summarized as means/standard deviations or medians/interquartile ranges, and categorical variables as counts and frequencies.
Results
There were 96 patients who received an OHBT during the study period; 90 were transported to a participating regional trauma center and 6 died prior to transport. Of the 90 patients, 82 (91 %) were successfully linked (Site 1: 36/39; Site 2: 46/51) between the air ambulance database and hospital trauma registries using indirect identifiers (age, sex, date and time of transport).
Conclusion
This study demonstrates the feasibility of linking prehospital and in-hospital records for OHBT recipients, achieving a 91.1 % linkage rate. Future work should aim to incorporate trip numbers and missing variables into hospital registries to support the establishment of a national OHBT registry to enhance prehospital trauma care.
{"title":"Rationale, development and feasibility of a national prehospital transfusion registry","authors":"Nura Khattab , Noah Zweig , Mahvareh Ahghari , Luis Da Luz , Melissa McGowan , Michael Peddle , Harley Meirovich , Aditi Khandelwal , Yulia Lin , Brodie Nolan","doi":"10.1016/j.resplu.2025.101211","DOIUrl":"10.1016/j.resplu.2025.101211","url":null,"abstract":"<div><h3>Background</h3><div>Out-of-hospital blood transfusion (OHBT) is an emerging practice for the management of hemorrhagic shock following trauma. The Canadian Prehospital and Transport Transfusion (CAN-PATT) network aims to standardize OHBT practices and assess the feasibility of linking out-of-hospital care with in-hospital outcomes through a national registry.</div></div><div><h3>Methods</h3><div>This was a retrospective cohort study of patients who received OHBT through an air ambulance program between September 2021 and July 2024 and were transported to one of two regional trauma centers. Prehospital data from the air ambulance database were linked using indirect identifiers to hospital data from the trauma registries and manually reviewed charts. The primary outcome was the percentage of prehospital and in-hospital records that could be successfully linked. Continuous variables were summarized as means/standard deviations or medians/interquartile ranges, and categorical variables as counts and frequencies.</div></div><div><h3>Results</h3><div>There were 96 patients who received an OHBT during the study period; 90 were transported to a participating regional trauma center and 6 died prior to transport. Of the 90 patients, 82 (91 %) were successfully linked (Site 1: 36/39; Site 2: 46/51) between the air ambulance database and hospital trauma registries using indirect identifiers (age, sex, date and time of transport).</div></div><div><h3>Conclusion</h3><div>This study demonstrates the feasibility of linking prehospital and in-hospital records for OHBT recipients, achieving a 91.1 % linkage rate. Future work should aim to incorporate trip numbers and missing variables into hospital registries to support the establishment of a national OHBT registry to enhance prehospital trauma care.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"28 ","pages":"Article 101211"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-26DOI: 10.1016/j.resplu.2026.101241
Yohei Okada , Janet E. Bray , Robert W. Neumar , Bryan F. McNally , Markus B. Skrifvars , Laurie J. Morrison , Niklas Nielsen , Theresa Olasveengen , Marcus E.H. Ong
Introduction
International collaborations in research for cardiac arrest are much needed to advance the science, translate this into practice and implement for impact. However, barriers and challenges remain for international collaboration. This paper aims to summarize the key discussions and consensus recommendations from the Wolf Creek XVIII Conference, focusing on strategies to optimize international collaborations in cardiac arrest research.
Methods
The 50th Anniversary Wolf Creek XVIII Conference was hosted by the Max Harry Weil Institute for Critical Care Research and Innovation in Ann Arbor, Michigan, USA on June 19–21, 2025. Strategies to Optimize International Collaborations in Cardiac Arrest Research was a topic of focused presentations and discussions by invited panelists and conference participants, made up of international academic and industry scientists, as well as thought leaders in the field of cardiac arrest resuscitation. An expert panel gave perspectives and insights that were debated and feedback was given by participants.
Results
Discussions were organized into three domains: registry research, basic science and translational research, and clinical trials. Several large-scale registries have collectively advanced data-driven resuscitation science through collaboration and mutual learning, while continuing to face challenges related to heterogeneity, privacy regulation, and data lag. Successful models like the Global Out-of-Hospital Cardiac Arrest Registries (GOHCAR) consortium highlight the importance of trust and sustained engagement. In preclinical research, the Transcontinental Cardiac Arrest Experimental Network for Discovery (TRANSCEND) aims to harmonize international laboratory studies. Clinical collaboration is progressing through multicenter randomized controlled trials such as the Sedation, temperature and pressure after cardiac arrest and resuscitation (STEPCARE), promoting inclusive, adaptive global research.
Conclusion
Sustained international collaboration across registries, laboratory studies, and clinical trials is key for advancing resuscitation science. By fostering trust, harmonization, and capacity building, these global networks can accelerate discovery and improve outcomes across cardiac arrest and other time-critical conditions.
在心脏骤停研究方面非常需要国际合作,以推进科学,将其转化为实践并实施影响。然而,国际合作仍然面临障碍和挑战。本文旨在总结Wolf Creek XVIII会议的主要讨论和共识建议,重点是优化心脏骤停研究的国际合作策略。方法Wolf Creek XVIII会议于2025年6月19日至21日在美国密歇根州安娜堡市由Max Harry Weil重症监护研究与创新研究所主办。优化心脏骤停研究国际合作的策略是由国际学术和行业科学家以及心脏骤停复苏领域的思想领袖组成的特邀小组成员和会议参与者重点介绍和讨论的主题。一个专家小组提出了观点和见解,与会者对此进行了辩论,并给出了反馈。结果讨论分为三个领域:注册研究、基础科学和转化研究以及临床试验。几个大型注册中心通过合作和相互学习共同推进了数据驱动的复苏科学,同时继续面临与异质性、隐私监管和数据滞后相关的挑战。全球院外心脏骤停登记(GOHCAR)联盟等成功模式强调了信任和持续参与的重要性。在临床前研究中,跨大陆心脏骤停发现实验网络(TRANSCEND)旨在协调国际实验室研究。临床合作正在通过多中心随机对照试验取得进展,如心脏骤停和复苏后的镇静、温度和压力(STEPCARE),促进包容性、适应性的全球研究。在注册、实验室研究和临床试验方面持续的国际合作是推进复苏科学的关键。通过促进信任、协调和能力建设,这些全球网络可以加速发现并改善心脏骤停和其他时间紧迫疾病的结果。
{"title":"Wolf Creek XVIII Part 7: strategies to optimize international collaborations in cardiac arrest research","authors":"Yohei Okada , Janet E. Bray , Robert W. Neumar , Bryan F. McNally , Markus B. Skrifvars , Laurie J. Morrison , Niklas Nielsen , Theresa Olasveengen , Marcus E.H. Ong","doi":"10.1016/j.resplu.2026.101241","DOIUrl":"10.1016/j.resplu.2026.101241","url":null,"abstract":"<div><h3>Introduction</h3><div>International collaborations in research for cardiac arrest are much needed to advance the science, translate this into practice and implement for impact. However, barriers and challenges remain for international collaboration. This paper aims to summarize the key discussions and consensus recommendations from the Wolf Creek XVIII Conference, focusing on strategies to optimize international collaborations in cardiac arrest research.</div></div><div><h3>Methods</h3><div>The 50th Anniversary Wolf Creek XVIII Conference was hosted by the Max Harry Weil Institute for Critical Care Research and Innovation in Ann Arbor, Michigan, USA on June 19–21, 2025. Strategies to Optimize International Collaborations in Cardiac Arrest Research was a topic of focused presentations and discussions by invited panelists and conference participants, made up of international academic and industry scientists, as well as thought leaders in the field of cardiac arrest resuscitation. An expert panel gave perspectives and insights that were debated and feedback was given by participants.</div></div><div><h3>Results</h3><div>Discussions were organized into three domains: registry research, basic science and translational research, and clinical trials. Several large-scale registries have collectively advanced data-driven resuscitation science through collaboration and mutual learning, while continuing to face challenges related to heterogeneity, privacy regulation, and data lag. Successful models like the Global Out-of-Hospital Cardiac Arrest Registries (GOHCAR) consortium highlight the importance of trust and sustained engagement. In preclinical research, the Transcontinental Cardiac Arrest Experimental Network for Discovery (TRANSCEND) aims to harmonize international laboratory studies. Clinical collaboration is progressing through multicenter randomized controlled trials such as the Sedation, temperature and pressure after cardiac arrest and resuscitation (STEPCARE), promoting inclusive, adaptive global research.</div></div><div><h3>Conclusion</h3><div>Sustained international collaboration across registries, laboratory studies, and clinical trials is key for advancing resuscitation science. By fostering trust, harmonization, and capacity building, these global networks can accelerate discovery and improve outcomes across cardiac arrest and other time-critical conditions.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"28 ","pages":"Article 101241"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146190448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-02-02DOI: 10.1016/j.resplu.2026.101250
Neil Krulewitz, Miles Lamberson, Ryan Walsh, Zachary Clark, Skyler Lentz, Lindsay Reardon
Background
Standard CPR guidelines recommend chest compressions over the lower half of the sternum; however, this often results in compressions over the left ventricular outflow tract (LVOT) or proximal aorta, impeding blood flow. Improved outcomes have been noted when compressions are directed over the left ventricle.
Objective
We evaluated whether transthoracic echocardiography (TTE) can accurately identify the mid-left ventricle (mid-LV) and whether this approach aligns more closely with the true mid-LV than the standard American Heart Association (AHA) compression location based on computed tomography (CT) of the chest.
Methods
In this prospective observational study of adults undergoing chest CT, providers marked the AHA-recommended compression site and performed limited TTE to localize and mark the mid-LV. Radiopaque markers were placed at these locations and compared to CT-identified true mid-LV positions.
Results
Among 65 patients, the mean distance from the AHA location to the true mid-LV based on chest CT was 74.2 mm. The distance from the ultrasound guided mid-LV marker to the true mid-LV was 64.6 mm. Ultrasound trained providers outperformed non-ultrasound trained providers in accuracy of localization. We found the AHA position to be cranial and medial to the true mid-LV. On CT, the most common structure beneath the AHA marker was the proximal ascending aorta (38.5%).
Conclusion
TTE-guided localization of the mid-LV is feasible and more accurate than the standard AHA landmark, particularly when performed by trained providers. A TTE-guided approach to mid-LV localization may optimize location of chest compression over the mid-LV, warranting further evaluation in resuscitation settings.
{"title":"Transthoracic echocardiography is superior to AHA guidelines location in identifying the left ventricle for chest compressions","authors":"Neil Krulewitz, Miles Lamberson, Ryan Walsh, Zachary Clark, Skyler Lentz, Lindsay Reardon","doi":"10.1016/j.resplu.2026.101250","DOIUrl":"10.1016/j.resplu.2026.101250","url":null,"abstract":"<div><h3>Background</h3><div>Standard CPR guidelines recommend chest compressions over the lower half of the sternum; however, this often results in compressions over the left ventricular outflow tract (LVOT) or proximal aorta, impeding blood flow. Improved outcomes have been noted when compressions are directed over the left ventricle.</div></div><div><h3>Objective</h3><div>We evaluated whether transthoracic echocardiography (TTE) can accurately identify the mid-left ventricle (mid-LV) and whether this approach aligns more closely with the true mid-LV than the standard American Heart Association (AHA) compression location based on computed tomography (CT) of the chest.</div></div><div><h3>Methods</h3><div>In this prospective observational study of adults undergoing chest CT, providers marked the AHA-recommended compression site and performed limited TTE to localize and mark the mid-LV. Radiopaque markers were placed at these locations and compared to CT-identified true mid-LV positions.</div></div><div><h3>Results</h3><div>Among 65 patients, the mean distance from the AHA location to the true mid-LV based on chest CT was 74.2 mm. The distance from the ultrasound guided mid-LV marker to the true mid-LV was 64.6 mm. Ultrasound trained providers outperformed non-ultrasound trained providers in accuracy of localization. We found the AHA position to be cranial and medial to the true mid-LV. On CT, the most common structure beneath the AHA marker was the proximal ascending aorta (38.5%).</div></div><div><h3>Conclusion</h3><div>TTE-guided localization of the mid-LV is feasible and more accurate than the standard AHA landmark, particularly when performed by trained providers. A TTE-guided approach to mid-LV localization may optimize location of chest compression over the mid-LV, warranting further evaluation in resuscitation settings.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"28 ","pages":"Article 101250"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146190488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-05DOI: 10.1016/j.resplu.2025.101215
Roelof G. Hup , Chaimae Bouchnaf , Myrthe A. Plaisier , Fatuma M.A. Omar , Tobias A. Machiavello , Sophie L.M. van Spreuwel , Hanno L. Tan , Xi Long , Rik Vullings
Aim
Out-of-hospital cardiac arrest (OHCA) is a leading cause of mortality, and rapid treatment is life-saving. Early detection is crucial to promptly start the chain of survival, leading to increasing interest in smartwatch-based OHCA detection. Introducing a grace period, during which the wearer can cancel a false alarm before emergency medical services (EMS) are notified, may improve system reliability. This study evaluates how this grace period affects false alarm rates.
Methods
In this study, 26 participants wore smartwatches that produced auditory, tactile or audiotactile alarms at random times during daytime, while instructed to cancel these alarms as quickly as possible. Response times were registered by the smartwatch, alongside demographic and time-of-day data. Bayesian time-to-event analysis assessed the effects of alarm type, time of day, and demographic variables.
Results
(Audio)tactile alarms significantly shortened response times compared to auditory-only alarms (HR 0.475, 95% CI: 0.38–0.59). Grace periods of 10 and 20 s would result in 98.3% (95% CI: 97.1–99.0%) and 99.6% (95% CI: 99.2–99.9%) of the (audio)tactile alarms being canceled, respectively. No clear evidence was found for meaningful effects of time of day, age or sex.
Conclusion
The findings in this study suggest that the application of a grace period to smartwatch-based OHCA detection systems may potentially reduce false alarms reaching EMS with only minor delays. Further research is warranted in a larger implementation set-up.
{"title":"Effect of a grace period on false alarm rates of smartwatch-based out-of-hospital cardiac arrest detection systems: a pilot study","authors":"Roelof G. Hup , Chaimae Bouchnaf , Myrthe A. Plaisier , Fatuma M.A. Omar , Tobias A. Machiavello , Sophie L.M. van Spreuwel , Hanno L. Tan , Xi Long , Rik Vullings","doi":"10.1016/j.resplu.2025.101215","DOIUrl":"10.1016/j.resplu.2025.101215","url":null,"abstract":"<div><h3>Aim</h3><div>Out-of-hospital cardiac arrest (OHCA) is a leading cause of mortality, and rapid treatment is life-saving. Early detection is crucial to promptly start the chain of survival, leading to increasing interest in smartwatch-based OHCA detection. Introducing a grace period, during which the wearer can cancel a false alarm before emergency medical services (EMS) are notified, may improve system reliability. This study evaluates how this grace period affects false alarm rates.</div></div><div><h3>Methods</h3><div>In this study, 26 participants wore smartwatches that produced auditory, tactile or audiotactile alarms at random times during daytime, while instructed to cancel these alarms as quickly as possible. Response times were registered by the smartwatch, alongside demographic and time-of-day data. Bayesian time-to-event analysis assessed the effects of alarm type, time of day, and demographic variables.</div></div><div><h3>Results</h3><div>(Audio)tactile alarms significantly shortened response times compared to auditory-only alarms (HR 0.475, 95% CI: 0.38–0.59). Grace periods of 10 and 20 s would result in 98.3% (95% CI: 97.1–99.0%) and 99.6% (95% CI: 99.2–99.9%) of the (audio)tactile alarms being canceled, respectively. No clear evidence was found for meaningful effects of time of day, age or sex.</div></div><div><h3>Conclusion</h3><div>The findings in this study suggest that the application of a grace period to smartwatch-based OHCA detection systems may potentially reduce false alarms reaching EMS with only minor delays. Further research is warranted in a larger implementation set-up.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"28 ","pages":"Article 101215"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145969132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-12-22DOI: 10.1016/j.resplu.2025.101200
Yavuz Yigit , Peter Alistair Cameron , Jassim Al Suwaidi , Loua Al Shaikh , Ibrahim Fawzy Hassan , Nidal Asaad , Nicholas Castle , Ian Lucas Howard , Abdulrahman Arabi , Atika Jabeen , Tim Richard Edmund Harris
Background
Out-of-hospital cardiac arrest (OHCA) remains a major global health challenge with persistently low survival rates despite advances in resuscitation science. This study aimed to evaluate the epidemiology, management, and outcomes of OHCA in Qatar using a national registry aligned with Utstein reporting standards.
Methods
A prospective observational cohort study was conducted across Qatar, enrolling all adult patients (≥18 years) with non-traumatic OHCA in whom resuscitation was attempted by the national EMS provider. Data were collected from EMS records, hospital EMRs, and mortuary databases. Survivors were followed up at 30 days and 12 months for neurological and quality-of-life outcomes. The primary outcome was 30-day survival with a favourable neurological status (CPC 1–2).
Results
Among 1238 OHCA cases, the median age was 52 years, and 80.5 % were male. Arrests occurred predominantly at home (64.0 %), with 61.8 % witnessed and 42.4 % receiving bystander CPR. Initial shockable rhythms were present in 29.7 %. ROSC was achieved in 44.8 %, survival to discharge was 17.8 %, and a favourable neurological outcome at 30 days was 13.5 %. Multivariable analysis identified witnessed arrest, prehospital defibrillation, and coronary reperfusion within 24 h as independent predictors of survival. The Utstein comparator group demonstrated a survival rate of 38.2 % and CPC 1–2 outcome in 32.8 % of cases.
Conclusions
OHCA outcomes in Qatar have improved markedly, with survival and CPC 1–2 rates more than doubling compared with prior national estimates. Survival now approaches levels seen in high-performing international systems, although within a younger patient population. Consistent predictors of outcome—including witnessed arrest, early defibrillation, and timely coronary reperfusion—emphasise the critical targets for strengthening OHCA systems of care.
{"title":"Out-of-hospital cardiac arrest in Qatar: epidemiology, management, and outcomes from a national registry study","authors":"Yavuz Yigit , Peter Alistair Cameron , Jassim Al Suwaidi , Loua Al Shaikh , Ibrahim Fawzy Hassan , Nidal Asaad , Nicholas Castle , Ian Lucas Howard , Abdulrahman Arabi , Atika Jabeen , Tim Richard Edmund Harris","doi":"10.1016/j.resplu.2025.101200","DOIUrl":"10.1016/j.resplu.2025.101200","url":null,"abstract":"<div><h3>Background</h3><div>Out-of-hospital cardiac arrest (OHCA) remains a major global health challenge with persistently low survival rates despite advances in resuscitation science. This study aimed to evaluate the epidemiology, management, and outcomes of OHCA in Qatar using a national registry aligned with Utstein reporting standards.</div></div><div><h3>Methods</h3><div>A prospective observational cohort study was conducted across Qatar, enrolling all adult patients (≥18 years) with non-traumatic OHCA in whom resuscitation was attempted by the national EMS provider. Data were collected from EMS records, hospital EMRs, and mortuary databases. Survivors were followed up at 30 days and 12 months for neurological and quality-of-life outcomes. The primary outcome was 30-day survival with a favourable neurological status (CPC 1–2).</div></div><div><h3>Results</h3><div>Among 1238 OHCA cases, the median age was 52 years, and 80.5 % were male. Arrests occurred predominantly at home (64.0 %), with 61.8 % witnessed and 42.4 % receiving bystander CPR. Initial shockable rhythms were present in 29.7 %. ROSC was achieved in 44.8 %, survival to discharge was 17.8 %, and a favourable neurological outcome at 30 days was 13.5 %. Multivariable analysis identified witnessed arrest, prehospital defibrillation, and coronary reperfusion within 24 h as independent predictors of survival. The Utstein comparator group demonstrated a survival rate of 38.2 % and CPC 1–2 outcome in 32.8 % of cases.</div></div><div><h3>Conclusions</h3><div>OHCA outcomes in Qatar have improved markedly, with survival and CPC 1–2 rates more than doubling compared with prior national estimates. Survival now approaches levels seen in high-performing international systems, although within a younger patient population. Consistent predictors of outcome—including witnessed arrest, early defibrillation, and timely coronary reperfusion—emphasise the critical targets for strengthening OHCA systems of care.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"28 ","pages":"Article 101200"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146190090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}