Resuscitation plus最新文献_第7页

Protection against post-resuscitation renal injury by Artesunate via inhibition of caspase-3/Gasdermin E -mediated pyroptosis 青蒿琥酯通过抑制caspase-3/Gasdermin E介导的焦亡来保护复苏后肾损伤

IF 2.4 Q3 CRITICAL CARE MEDICINE

Resuscitation plus

Pub Date : 2025-11-01 DOI: 10.1016/j.resplu.2025.101138

Qianqian Wang , Peng Shen , Wang Wu , Jiangang Zhu , Jiefeng Xu

Background

Post-resuscitation renal injury is the common complication after cardiac arrest and resuscitation. Artesunate (Art) has been confirmed to protect against regional ischemia–reperfusion injuries in multiple organs. This study aimed to determine the effects of Art on post-resuscitation renal injury and clarify whether the mechanism is related to inhibition of the caspase-3/Gasdermin E pyroptosis pathway.

Methods

Twenty-two swine were divided into a Sham, Cardiopulmonary resuscitation (CPR), and CPR + Art groups. Blood samples were collected to measure serum creatinine and blood urea nitrogen levels. Samples of renal tissue were obtained for histopathological assessment of injury, the apoptosis index, contents of proinflammatory cytokines, kidney injury molecule-1, neutrophil gelatinase-associated lipid carrier, and pyroptosis-related protein expression levels.

Results

Compared with the Sham group, the biomarkers of renal injury were significantly increased in the CPR and CPR + Art groups. Levels of these biomarkers were significantly lower in the CPR + Art group than in the CPR group. Renal pathological damage and cell apoptosis were observed in the CPR and CPR + Art groups after resuscitation and were markedly less severe in the CPR + Art group. The expression levels of caspase-3/Gasdermin E pyroptosis related proteins and proinflammatory cytokines were significantly increased in the CPR and CPR + Art groups compared with the Sham group. Treatment with Art significantly decreased the expression of these indicators of cell pyroptosis.

Conclusions

Art treatment could alleviate post-resuscitation renal injury, and its mechanism may be related to the inhibition of caspase-3/Gasdermin E pyroptosis pathway.

背景复苏后肾损伤是心脏骤停复苏后常见的并发症。青蒿琥酯（Art）已被证实对多器官局部缺血再灌注损伤具有保护作用。本研究旨在确定Art对复苏后肾损伤的影响，并阐明其机制是否与抑制caspase-3/Gasdermin E焦亡通路有关。方法将22头猪分为假手术组、心肺复苏术组和心肺复苏术+ Art组。采集血样测定血清肌酐和尿素氮水平。取肾组织标本，进行损伤组织病理学评估、细胞凋亡指数、促炎细胞因子含量、肾损伤分子-1、中性粒细胞明胶酶相关脂质载体、焦亡相关蛋白表达水平。结果与Sham组比较，CPR组和CPR + Art组肾损伤生物标志物均显著升高。这些生物标志物的水平在CPR + Art组明显低于CPR组。复苏后，CPR组和CPR + Art组肾脏病理损害和细胞凋亡明显减轻，而CPR + Art组明显减轻。与Sham组相比，CPR组和CPR + Art组caspase-3/Gasdermin E焦亡相关蛋白及促炎因子的表达水平均显著升高。Art治疗显著降低了这些细胞焦亡指标的表达。结论art治疗可减轻复苏后肾损伤，其机制可能与抑制caspase-3/Gasdermin E焦亡途径有关。

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引用次数: 0

Correspondence: On the “2-minute rule” 通信：关于“2分钟规则”

IF 2.4 Q3 CRITICAL CARE MEDICINE

Resuscitation plus

Pub Date : 2025-11-01 DOI: 10.1016/j.resplu.2025.101124

John A. Stewart

引用次数: 0

Early EEG and serum biomarkers for prognostication after cardiac arrest 早期脑电图和血清生物标志物对心脏骤停后预后的影响

IF 2.4 Q3 CRITICAL CARE MEDICINE

Resuscitation plus

Pub Date : 2025-11-01 DOI: 10.1016/j.resplu.2025.101154

Inken Alina Strate , Johannes G. Krabbe , Sjoukje Nutma , Albertus Beishuizen , Wytze J. Vermeijden , Francois H.M. Kornips , Norbert A. Foudraine , Jeannette Hofmeijer , Michel J.A.M. van Putten

Rationale

Early electroencephalography (EEG), initiated within 12 h after cardiac arrest, allows reliable prognostication in approximately 50 % of comatose patients. Serum biomarkers may complement early EEG–based outcome prediction, particularly in indeterminate cases. We evaluated the potential additive prognostic value of the serum biomarkers neuron-specific enolase (NSE), neurofilament light chain (NfL), S100 calcium binding protein β (S100B), and phosphorylated tau (p-Tau 181) when combined with early EEG.

Methods

In this pilot study, we analysed serum biomarker concentrations at multiple time points (<12 h, 24 h, 72 h, 7 days) post-CA in comatose out-of-hospital CA patients included in the ghrelin in coma (GRECO) trial. EEG recordings were visually evaluated at 12 and 24 h post-arrest. Neurological outcomes were assessed using the Cerebral Performance Category (CPC) score at 6 months, dichotomised into good (CPC 1–2) or poor (CPC 3–5).

Results

A total of 49 patients were included; 24 (49 %) had a poor neurological outcome at 6 months. Serum biomarker concentrations were significantly higher in poor-outcome patients within 24 h post-CA. NfL achieved an AUC of 0.90, followed by p-Tau181 (AUC 0.81), S100B (AUC 0.80) and NSE (AUC 0.76) for poor neurological outcome at 24 h post-CA. In 40 patients with EEG, NfL > 100 pg/mL reclassified indeterminate cases as likely poor outcome, with >128 pg/mL at any time achieving 100 % specificity, unlike other biomarkers.

Significance

NfL demonstrated superior prognostic performance compared to other serum biomarkers. Our preliminary findings suggest added prognostic value of NfL when combined with early EEG (12–24 h), particularly in patients with indeterminate EEG findings.

在心脏骤停后12小时内开始进行早期脑电图（EEG），可以对大约50%的昏迷患者进行可靠的预测。血清生物标志物可以补充早期基于脑电图的预后预测，特别是在不确定的病例中。我们评估了血清生物标志物神经元特异性烯醇化酶（NSE）、神经丝轻链（NfL）、S100钙结合蛋白β (S100B)和磷酸化tau （p-Tau 181）结合早期脑电图的潜在附加预后价值。方法在这项中试研究中，我们分析了ghrelin in coma （GRECO）试验中昏迷院外CA患者在CA后多个时间点（12小时、24小时、72小时、7天）的血清生物标志物浓度。在骤停后12和24小时目测脑电图记录。在6个月时使用脑功能分类（CPC）评分评估神经系统预后，分为良好（CPC 1-2）或差（CPC 3-5）。结果共纳入49例患者；24例（49%）患者6个月时神经系统预后较差。不良预后患者在ca后24小时内血清生物标志物浓度显著升高。在ca后24小时神经预后较差时，NfL的AUC为0.90，其次是p-Tau181 （AUC 0.81）、S100B （AUC 0.80）和NSE （AUC 0.76）。在40例脑电图患者中，100 pg/mL的NfL将不确定病例重新分类为可能的不良预后，与其他生物标志物不同，128 pg/mL的NfL在任何时候都能达到100%的特异性。与其他血清生物标志物相比，enfl具有更好的预后表现。我们的初步研究结果表明，当与早期脑电图（12-24小时）相结合时，NfL具有更大的预后价值，特别是在脑电图结果不确定的患者中。

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引用次数: 0

A comparison of time efficiency in simulated out-of-hospital cardiac arrest using drone-delivered automated external defibrillators 使用无人机自动体外除颤器模拟院外心脏骤停的时间效率比较

IF 2.4 Q3 CRITICAL CARE MEDICINE

Resuscitation plus

Pub Date : 2025-11-01 DOI: 10.1016/j.resplu.2025.101146

Liying Pi , Siyuan Wei , Zhixin Wu , Yixin Yang , Qiao Chen , Chaofan He , Yonghong Du , Yuanyi Li , Yuyuan You

引用次数: 0

Out-of-hospital cardiac arrest outcomes following EMS resuscitation protocol revision during the COVID-19 pandemic: a population-based study COVID-19大流行期间EMS复苏方案修订后的院外心脏骤停结果：一项基于人群的研究

IF 2.4 Q3 CRITICAL CARE MEDICINE

Resuscitation plus

Pub Date : 2025-11-01 DOI: 10.1016/j.resplu.2025.101134

Ryota Kaichi , Yoshinori Matsuoka , Tatsuya Norii , Yasukazu Hijikata , Chisato Miyakoshi , Taro Matsuoka , Naoto Hanamura , Naoto Yuge , Futoshi Toda , Takahiro Itaya , Yoshie Yamada , Yusuke Ogawa , Yosuke Yamamoto , Koichi Ariyoshi

Aim

We aimed to evaluate the association between emergency medical service (EMS) protocols with enhanced infection control precautions against COVID-19 and the outcomes of patients with out-of-hospital cardiac arrest (OHCA), as well as various EMS-related time intervals, in Japan.

Methods

We conducted a population-based cohort study of OHCAs in Kobe, Japan, between 2016 and 2023. In May 2020, the Japanese resuscitation protocols for EMS were revised in accordance with the guidance of the International Liaison Committee on Resuscitation. The outcomes of interest were favourable neurological outcomes and several time metrics related to EMS activities. We evaluated changes in outcomes before and after the protocol revision using segmented regression for interrupted time-series analyses.

Results

A total of 10,126 patients were enrolled during the period. The proportion of favourable neurological outcomes decreased after the protocol revision: the change in the intercept was −3.4 % (95 % confidence interval [CI], −5.2 % to −1.7 %) and in the trend was 0.01 % (95 % CI, −0.02 % to 0.04 %). Delays were observed in airway management completion (186 s [95 % CI, 131 to 241] for the intercept and 6.13 s [95 % CI, 4.22 to 8.03] for the trend) and establishment of intravenous access (99 s [95 % CI, 55 to 143] for the intercept and 3.93 s [95 % CI, 2.84 to 5.02] for the trend).

Conclusion

OHCA outcomes worsened after the protocol revision, with delays in several key EMS interventions. When encountering future pandemics, resuscitation protocols should be designed to balance infection control and the quality of advanced life support.

本研究旨在评估日本加强COVID-19感染控制预防措施的紧急医疗服务（EMS）方案与院外心脏骤停（OHCA）患者结局以及各种EMS相关时间间隔之间的关系。方法2016年至2023年，我们在日本神户开展了一项基于人群的ohca队列研究。2020年5月，根据国际复苏联络委员会的指导，对EMS的日本复苏方案进行了修订。令人感兴趣的结果是良好的神经预后和与EMS活动相关的几个时间指标。我们使用分段回归进行中断时间序列分析，评估方案修订前后结果的变化。结果共纳入10126例患者。方案修订后，神经系统预后良好的比例下降：截距变化为- 3.4%(95%置信区间[CI]， - 5.2%至- 1.7%)，趋势变化为0.01% （95% CI, - 0.02%至0.04%）。观察到气道管理完成延迟（阻断时间为186秒[95% CI， 131至241]，趋势时间为6.13秒[95% CI， 4.22至8.03]）和静脉通路建立延迟（阻断时间为99秒[95% CI， 55至143]，趋势时间为3.93秒[95% CI， 2.84至5.02]）。结论方案修订后ohca结果恶化，延迟了几个关键的EMS干预措施。当遇到未来的大流行时，复苏方案的设计应平衡感染控制和晚期生命支持的质量。

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引用次数: 0

Adrenaline and return of spontaneous circulation during in-hospital cardiac arrest 院内心脏骤停期间肾上腺素与自然循环的恢复

IF 2.4 Q3 CRITICAL CARE MEDICINE

Resuscitation plus

Pub Date : 2025-11-01 DOI: 10.1016/j.resplu.2025.101140

A. Norvik , E. Unneland , D. Bergum , J.P. Loennechen , J.T. Kvaløy , E. Aramendi , J. Urtega , E. Skogvoll

Introduction

Adrenaline provides inotropic, chronotropic and vasopressor effects and is a cornerstone drug during cardiopulmonary resuscitation. This study of in-hospital cardiac arrest aimed to investigate the effect of adrenaline on the return of spontaneous circulation (ROSC) in primary pulseless electrical activity (PEA).

Method

In-hospital cardiac arrests episodes at St. Olav University Hospital (Norway) were prospectively registered between 2018 and 2022, among these were 73 episodes with primary PEA. Time of adrenaline administration was obtained with minutes precision by reviewing the clinical record and interviewing personnel, thereby establishing a consistent timeline. We investigated transitions from primary PEA to ROSC following adrenaline administration using time-to-event models.

Results

Adrenaline exerted its maximum effect between 45 and 85 s after administration and strongly favored the transition from primary PEA to ROSC, with an intensity ratio of 5.03 (p < 0.001). Repeated doses of adrenaline, however, had no effect in case of absence of an initial response. Basic life support alone yielded a transition intensity from primary PEA to ROSC of about 0.06, i.e., 6 % per minute.

Conclusion

We found a rapid and five-fold increase in the transition intensity from primary PEA to ROSC approximately one minute after adrenaline administration. Repeated doses in the absence of an initial response did not alone increase the transition probability.

肾上腺素具有肌力、变时性和血管加压作用，是心肺复苏的基础药物。本研究旨在探讨肾上腺素对原发性无脉电活动（PEA）中自发循环（ROSC）恢复的影响。2018年至2022年期间，在挪威圣奥拉夫大学医院（St. Olav University Hospital）前瞻性登记了方法学院内心脏骤停事件，其中73例为原发性PEA。肾上腺素给药时间通过查阅临床记录和采访人员获得，精确到分钟，从而建立一个一致的时间表。我们使用时间-事件模型研究肾上腺素给药后从原发性PEA到ROSC的转变。结果肾上腺素在给药后45 ~ 85 s发挥最大作用，有利于原发性PEA向ROSC过渡，强度比为5.03 （p < 0.001）。然而，在没有初始反应的情况下，重复剂量的肾上腺素没有效果。单独的基本生命支持产生了从初级PEA到ROSC的转换强度约为0.06，即每分钟6%。结论肾上腺素给药后约1分钟，原发性PEA向ROSC的转变强度迅速增加5倍。在没有初始反应的情况下，重复给药并不能单独增加过渡概率。

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引用次数: 0

Telephone-assisted cardiopulmonary resuscitation in a simulated environment: A pilot exploratory study evaluating first responder adherence and dispatcher performance 模拟环境中的电话辅助心肺复苏：一项评估急救人员依从性和调度员表现的试点探索性研究

IF 2.4 Q3 CRITICAL CARE MEDICINE

Resuscitation plus

Pub Date : 2025-11-01 DOI: 10.1016/j.resplu.2025.101149

Jordi Caplliure-Llopis , Laura Bonet , Gabriele Kersulyte , Josep Primo-Paris , Ana Micó-Máñez , Carmen Escriche-López , Jose Enrique de la Rubia Ortí

Background

Out-of-hospital cardiac arrest (OHCA) remains a major public health challenge, and telephone-assisted cardiopulmonary resuscitation (T-CPR) is a key strategy to improve survival. However, real-time analyses of dispatcher–rescuer interaction are scarce.

Methods

A pilot study was conducted in the Valencian Community (Spain) using simulated OHCA scenarios to evaluate first responder adherence to T-CPR instructions and dispatcher performance. This exploratory study included six untrained lay callers and six dispatchers (five nurses, one physician) who participated in simulated emergency calls routed through the regional emergency coordination center (CICU). All calls were audiovisually recorded and analysed using a checklist derived from ERC 2021/AHA 2020 guidelines. Technical CPR parameters were collected from a manikin with QCPR technology.

Results

Time to cardiac arrest recognition varied widely (50 s–3:48 min), with overall delays exceeding 5 min in two cases. Basic instructions (supine position, hand placement) were consistently communicated, but only 50 % of dispatchers emphasized correct compression depth. Interruptions in CPR occurred in four of six cases. Lay responders reliably followed simple instructions but struggled with technical aspects: only 33.3 % achieved adequate compression depth and rate. Significant correlations were observed between compression depth, rate, and rescuer age (ρ = –0.868; p = 0.025). AED use was systematically omitted.

Conclusions

This pilot study highlights variability in dispatcher recognition times and inconsistencies in communication of critical CPR parameters. First responders adhered better to simple than technical instructions. Findings underscore the need for structured, standardized protocols and enhanced dispatcher training to optimize T-CPR effectiveness.

院外心脏骤停（OHCA）仍然是一个重大的公共卫生挑战，电话辅助心肺复苏（T-CPR）是提高生存率的关键策略。然而，对调度员-救援人员互动的实时分析很少。方法在西班牙巴伦西亚社区进行了一项试点研究，使用模拟的OHCA场景来评估急救人员对T-CPR指令的依从性和调度员的表现。这项探索性研究包括六名未经训练的外行呼叫者和六名调度员（五名护士，一名医生），他们参加了通过区域紧急协调中心（CICU）路由的模拟紧急呼叫。使用ERC 2021/AHA 2020指南的清单对所有呼叫进行视听记录和分析。采用QCPR技术采集人体模型的CPR技术参数。结果对心脏骤停的识别时间差异很大（50 - 3:48 min）， 2例总延迟超过5 min。基本的指示（仰卧位，手的位置）是一致的，但只有50%的调度员强调正确的按压深度。6例中有4例出现心肺复苏中断。外行响应人员可靠地遵循了简单的指令，但在技术方面存在困难：只有33.3%的人达到了足够的压缩深度和压缩速率。按压深度、按压率与施救者年龄之间存在显著相关（ρ = -0.868; p = 0.025）。系统地省略了AED的使用。这项初步研究强调了调度员识别时间的差异性和关键CPR参数沟通的不一致性。急救人员更容易遵守简单的技术说明。研究结果强调需要结构化、标准化的方案和加强调度员培训，以优化T-CPR的有效性。

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引用次数: 0

Acute clinical adverse events associated with the LUCAS chest compression system 与LUCAS胸按压系统相关的急性临床不良事件

IF 2.4 Q3 CRITICAL CARE MEDICINE

Resuscitation plus

Pub Date : 2025-11-01 DOI: 10.1016/j.resplu.2025.101139

Syed Shaheer Ali , Konmal Ali , Aviva Cohen , Robert Kropp , Sara Sakowitz , Yas Sanaiha , Nichole Bosson , Peyman Benharash

Background

Mechanical cardiopulmonary resuscitation (CPR) devices, such as the Lund University Cardiac Assist System (LUCAS), were developed to reduce variability in the quality of chest compressions and improve outcomes of cardiac arrest. With increasing adoption of mechanical CPR devices, understanding the nature and frequency of device-related complications is critical to ensuring patient safety.

Methods

This was a retrospective analysis of all adverse events involving the LUCAS 1.0, 2.0, 2.1, 2.2, 3.0 and 3.1 devices from 2015 to 2024 Manufacturer and User Facility Device Experience (MAUDE) maintained by the US Food and Drug −Administration. Reports were manually reviewed, categorized by device subtype, and further stratified by type of complication. Events were grouped into device- or patient-related categories to identify trends and potential causes.

Results

A total of 255 adverse events were reported, with an increase from 12 events in 2015 to 33 in 2024. Most events were associated with LUCAS 1.0 (50.2 %) and LUCAS 2.0 (27.1 %). The most frequent device-related issues involved device defect (53.7 %) and power failure (26.7 %). Patient-related complications included soft tissue injury (22.0 %), internal organ injury (20.4 %), and chest compression interruption (13.7 %). Malfunctions such as abrupt stoppage, loss of suction, or misalignment were frequently noted as contributing factors.

Conclusion

Reported adverse events associated with LUCAS use include device malfunction and deployment issues, with serious patient harm including death or organ injury, in some cases. As mechanical CPR becomes more widely adopted, knowledge of the most common complications can inform operator training and potential mitigating strategies to minimize adverse outcomes.

机械心肺复苏（CPR）装置，如隆德大学心脏辅助系统（LUCAS），是为了减少胸外按压质量的变化，改善心脏骤停的结果而开发的。随着机械心肺复苏术设备的日益普及，了解设备相关并发症的性质和频率对于确保患者安全至关重要。方法回顾性分析2015年至2024年美国食品药品监督管理局（fda）维护的制造商和用户设施设备体验（MAUDE）中涉及LUCAS 1.0、2.0、2.1、2.2、3.0和3.1设备的所有不良事件。报告由人工审核，按器械亚型分类，并进一步按并发症类型分层。事件被分为与器械或患者相关的类别，以确定趋势和潜在原因。结果共报告不良事件255件，由2015年的12件增加到2024年的33件。大多数事件与LUCAS 1.0（50.2%）和LUCAS 2.0（27.1%）相关。最常见的设备相关问题包括设备缺陷（53.7%）和电源故障（26.7%）。患者相关并发症包括软组织损伤（22.0%）、内脏损伤（20.4%）和胸部按压中断（13.7%）。故障，如突然停止，失去吸力，或不对准经常被认为是促成因素。结论：报道的与LUCAS使用相关的不良事件包括设备故障和部署问题，在某些情况下会对患者造成严重伤害，包括死亡或器官损伤。随着机械心肺复苏术的广泛应用，了解最常见的并发症可以为操作人员培训和潜在的缓解策略提供信息，以最大限度地减少不良后果。

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引用次数: 0

Chest compression during sustained inflation versus 3:1 compression-to-ventilation ratio during neonatal cardiopulmonary resuscitation of asphyxiated piglets 持续充气时胸部按压与窒息仔猪新生儿心肺复苏时按压通气比3:1的比较

IF 2.4 Q3 CRITICAL CARE MEDICINE

Resuscitation plus

Pub Date : 2025-11-01 DOI: 10.1016/j.resplu.2025.101144

Melanie Shaker , Anne Lee Solevåg , Megan O’Reilly , Georg M. Schmölzer

Background

Current neonatal resuscitation guidelines recommend using the 3:1 chest compression-to-ventilation (C:V) ratio technique. However, an alternative technique using continuous compressions superimposed with a high distending pressure or sustained inflation (CC + SI) may improve return of spontaneous circulation (ROSC), survival, and post-resuscitation outcomes.

Objective

In a piglet model of asphyxia-induced cardiac arrest, compare time to ROSC with CC + SI or 3:1C:V technique for providing neonatal cardiopulmonary resuscitation (CPR).

Methods

Secondary analysis of 132 term newborn mixed breed piglets (1–3 days of age, weighing 1.7–2.4 kg) from six different studies, which were exposed to 30–50 min of normocapnic hypoxia followed by asphyxia until cardiac arrest. This was followed by CPR with either the CC + SI or 3:1C:V technique.

Results

Although the proportion of piglets achieving ROSC was similar between CC + SI and 3:1C:V [59/83 (71 %) vs. 40/49 (82 %)], the time to ROSC was significantly shorter with CC + SI [median (IQR), 87.5 (66.8–147.5) vs. 120 (76.5–267) s; p = 0.0097], corresponding to a mean difference of –73.9 s (95 % CI –122.5 to –25.3). Survival up to 4 h did not differ between groups (risk ratios 1.04, 95 % Confidence intervals 0.82–1.32), with mean (SD) survival time among ROSC survivors of 237 (18) min for CC + SI vs 220 (55) min for 3:1C:V (p = 0.0623). In adjusted analyses, CC + SI yielded faster time to ROSC (Geometric Mean Ratio 0.67, 95 % CI 0.50–0.88), with no effect modification by FiO₂, but a rate-dependent effect on time to ROSC; 4-h survival did not differ between methods.

Conclusions

Use of the CC + SI technique during neonatal piglet resuscitation leads to a faster ROSC, with no difference in survival.

当前新生儿复苏指南推荐使用3:1胸外按压与通气（C:V）比技术。然而，另一种替代技术，使用持续按压叠加高膨胀压力或持续充气（CC + SI），可能会改善自然循环（ROSC）的恢复，生存率和复苏后的结果。目的在仔猪窒息性心脏骤停模型中，比较ROSC与CC + SI或3:1C:V技术提供新生儿心肺复苏（CPR）的时间。方法对来自6个不同研究的132头足月新生混合仔猪（1-3日龄，体重1.7-2.4 kg）进行二次分析，这些仔猪暴露于30-50 min的低氧环境中，随后窒息直至心脏骤停。随后采用CC + SI或3:1C:V技术进行心肺复苏术。结果虽然CC + SI和3:1C:V仔猪达到ROSC的比例相似[59/83 (71%)vs. 40/49(82%)]，但CC + SI仔猪达到ROSC的时间显著缩短[中位数（IQR）为87.5 (66.8-147.5)vs. 120 (76.5-267) s；p = 0.0097]，平均差异为-73.9 s （95% CI -122.5 ~ -25.3）。4小时的存活率在两组之间没有差异（风险比1.04,95%可信区间0.82-1.32），CC + SI组ROSC幸存者的平均（SD）生存时间为237（18）分钟，而3:1C:V组为220（55）分钟（p = 0.0623）。在校正分析中，CC + SI产生更快的ROSC时间（几何平均比0.67,95% CI 0.50-0.88）， FiO2没有影响，但对ROSC时间有率相关的影响；不同方法的4小时存活率无差异。结论在新生儿仔猪复苏过程中使用CC + SI技术可使ROSC更快，但对存活率无显著影响。

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引用次数: 0

Non-invasive cerebral pulse rate monitoring during two low-cardiac-output events after birth – A case report 出生后两次低心输出量事件的无创脑脉搏率监测- 1例报告

IF 2.4 Q3 CRITICAL CARE MEDICINE

Resuscitation plus

Pub Date : 2025-11-01 DOI: 10.1016/j.resplu.2025.101147

Lukas P. Mileder, Christoph Schlatzer, Bernhard Schwaberger, Gerhard Pichler, Nariae Baik-Schneditz

A female, term neonate required cardiopulmonary resuscitation (CPR) for 45 s after vaginal birth. A novel cerebral pulsatile near-infrared spectroscopy (pNIRS) mode guided chest compressions during CPR, as it showed a cerebral pulse rate of around 100 per minute, suggesting sufficient perfusion pressure. After initial stabilization and intubation due to minimal breathing efforts, she spontaneously developed broad complex tachycardia. During this instance, the pNIRS detected a regular cerebral pulse rate, indicating stable cerebral perfusion and reassuring that CPR and emergency defibrillation were not required. While requiring further investigation, pNIRS holds promise for guiding and optimizing neonatal CPR.

一位女性，足月新生儿在阴道分娩后需要心肺复苏（CPR） 45秒。一种新的脑脉冲近红外光谱（pNIRS）模式在心肺复苏术中指导胸部按压，因为它显示脑脉冲率约为每分钟100次，表明灌注压力足够。在最初的稳定和插管后，由于最小的呼吸努力，她自发地出现了广泛的复杂心动过速。在本例中，pNIRS检测到正常的脑脉搏率，表明脑灌注稳定，并使人放心，不需要心肺复苏术和紧急除颤。虽然需要进一步的研究，但pNIRS有望指导和优化新生儿心肺复苏。

引用次数: 0