Pub Date : 2024-11-07DOI: 10.1016/j.resplu.2024.100817
Eva M. Schwindt , Reinhold Stockenhuber , Jens Christian Schwindt
Aim of the study
Although neonatal resuscitation is rare, and high-risk births usually occur in specialised centres, unexpected resuscitation measures may be necessary during births that are initially considered low-risk. This survey assessed the practices of healthcare providers in Austrian hospitals for postnatal resuscitation and evaluated their self-assessed airway management skills for newborns.
Methods
An online survey was distributed to all staff members responsible for the postnatal care of newborns in hospitals with obstetrics in Austria through the heads of departments (paediatrics, obstetrics, and anaesthesiology). The results are presented in terms of hospital care level and birth volume.
Results
In total, 79.5 % of all hospitals with maternity units in Austria participated in the survey. Preparedness was found to be improved with the level of care provided by the hospital. Overall, 50.4 % of the respondents did not feel adequately prepared for neonatal emergencies, and 35.0 % rated their face mask ventilation skills as insufficient. According to the survey results in 61.3 % of included hospitals or 52.5 % of births in Austria, safe endotracheal intubation cannot be provided.
Conclusion
A significant proportion of healthcare workers in Austria responsible for postnatal newborn care do not feel adequately prepared for newborn emergencies.
{"title":"Ventilation practices and preparedness of healthcare providers in term newborn resuscitation: A comprehensive survey study in Austrian hospitals","authors":"Eva M. Schwindt , Reinhold Stockenhuber , Jens Christian Schwindt","doi":"10.1016/j.resplu.2024.100817","DOIUrl":"10.1016/j.resplu.2024.100817","url":null,"abstract":"<div><h3>Aim of the study</h3><div>Although neonatal resuscitation is rare, and high-risk births usually occur in specialised centres, unexpected resuscitation measures may be necessary during births that are initially considered low-risk. This survey assessed the practices of healthcare providers in Austrian hospitals for postnatal resuscitation and evaluated their self-assessed airway management skills for newborns.</div></div><div><h3>Methods</h3><div>An online survey was distributed to all staff members responsible for the postnatal care of newborns in hospitals with obstetrics in Austria through the heads of departments (paediatrics, obstetrics, and anaesthesiology). The results are presented in terms of hospital care level and birth volume.</div></div><div><h3>Results</h3><div>In total, 79.5 % of all hospitals with maternity units in Austria participated in the survey. Preparedness was found to be improved with the level of care provided by the hospital. Overall, 50.4 % of the respondents did not feel adequately prepared for neonatal emergencies, and 35.0 % rated their face mask ventilation skills as insufficient. According to the survey results in 61.3 % of included hospitals or 52.5 % of births in Austria, safe endotracheal intubation cannot be provided.</div></div><div><h3>Conclusion</h3><div>A significant proportion of healthcare workers in Austria responsible for postnatal newborn care do not feel adequately prepared for newborn emergencies.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"20 ","pages":"Article 100817"},"PeriodicalIF":2.1,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142659591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-05DOI: 10.1016/j.resplu.2024.100825
Hannes Ecker , Niels-Benjamin Adams , Michael Schmitz , Wolfgang A. Wetsch
Background
Video assisted cardiopulmonary resuscitation (V-CPR) has demonstrated to be efficient in improving CPR quality and patient outcomes, as Emergency Medical Service (EMS) dispatchers can use the video stream of a caller for diagnostic purposes and give instructions in a CPR scenario. However, the new challenges faced by EMS dispatchers during video-guided CPR (V-CPR)—such as analyzing the video stream, providing feedback to the caller, and managing stress—demand innovative solutions. This study explores the feasibility of incorporating an open-source “machine-learning” tool (artificial intelligence – AI), to evaluate the feasibility and accuracy in correctly detecting the actual compression frequency and compression depth in video footage of a simulated CPR.
Design
MediaPipe Pose Landmark Detection (Google LLC, Mountain View, CA, USA), an open-source AI software using “machine-learning” models to detect human bodies in images and videos, was programmed to assess compression frequency an depth in nine videos, showing CPR on a resuscitation manikin. Compression frequency and depth were assessed from compression to compression with AI software and were compared to the manikin’s internal software (QCPR, Laerdal, Stavanger, Norway). After testing for Gaussian distribution, means of non-gaussian data were compared using Wilcoxon matched-pairs signed rank test and the Bland Altman method.
Main results
MediaPipe Pose Landmark Detection successfully identified and tracked the person performing CPR in all nine video sequences. There were high levels of agreement between compression frequencies derived from AI and manikin’s software. However, the precision of compression depth showed major inaccuracies and was overall not accurate.
Conclusions
This feasibility study demonstrates the potential of open-source “machine-learning” tools in providing real-time feedback on V-CPR video sequences. In this pilot study, an open-source landmark detection AI software was able to assess CPR compression frequency with high agreement to actual frequency derived from the CPR manikin. For compression depth, its performance was not accurate, suggesting the need for adjustment. Since the software used is currently not intended for medical use, further development is necessary before the technology can be evaluated in real CPR.
{"title":"Feasibility of real-time compression frequency and compression depth assessment in CPR using a “machine-learning” artificial intelligence tool","authors":"Hannes Ecker , Niels-Benjamin Adams , Michael Schmitz , Wolfgang A. Wetsch","doi":"10.1016/j.resplu.2024.100825","DOIUrl":"10.1016/j.resplu.2024.100825","url":null,"abstract":"<div><h3>Background</h3><div>Video assisted cardiopulmonary resuscitation (V-CPR) has demonstrated to be efficient in improving CPR quality and patient outcomes, as Emergency Medical Service (EMS) dispatchers can use the video stream of a caller for diagnostic purposes and give instructions in a CPR scenario. However, the new challenges faced by EMS dispatchers during video-guided CPR (V-CPR)—such as analyzing the video stream, providing feedback to the caller, and managing stress—demand innovative solutions. This study explores the feasibility of incorporating an open-source “machine-learning” tool (artificial intelligence – AI), to evaluate the feasibility and accuracy in correctly detecting the actual compression frequency and compression depth in video footage of a simulated CPR.</div></div><div><h3>Design</h3><div>MediaPipe Pose Landmark Detection (Google LLC, Mountain View, CA, USA), an open-source AI software using “machine-learning” models to detect human bodies in images and videos, was programmed to assess compression frequency an depth in nine videos, showing CPR on a resuscitation manikin. Compression frequency and depth were assessed from compression to compression with AI software and were compared to the manikin’s internal software (QCPR, Laerdal, Stavanger, Norway). After testing for Gaussian distribution, means of non-gaussian data were compared using Wilcoxon matched-pairs signed rank test and the Bland Altman method.</div></div><div><h3>Main results</h3><div>MediaPipe Pose Landmark Detection successfully identified and tracked the person performing CPR in all nine video sequences. There were high levels of agreement between compression frequencies derived from AI and manikin’s software. However, the precision of compression depth showed major inaccuracies and was overall not accurate.</div></div><div><h3>Conclusions</h3><div>This feasibility study demonstrates the potential of open-source “machine-learning” tools in providing real-time feedback on V-CPR video sequences. In this pilot study, an open-source landmark detection AI software was able to assess CPR compression frequency with high agreement to actual frequency derived from the CPR manikin. For compression depth, its performance was not accurate, suggesting the need for adjustment. Since the software used is currently not intended for medical use, further development is necessary before the technology can be evaluated in real CPR.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"20 ","pages":"Article 100825"},"PeriodicalIF":2.1,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142587356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-05DOI: 10.1016/j.resplu.2024.100821
Talip E. Eroglu , Ruben Coronel , Fredrik Folke , Gunnar Gislason
Objective
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) improve cardiovascular outcomes in patients with type 2 diabetes, but few studies have studied the risk of out-of-hospital cardiac arrest (OHCA). We investigated whether GLP-1 RA use reduce OHCA risk in type 2 diabetes when compared to dipeptidyl peptidase-4 inhibitor (DPP-4i) use.
Methods
We identified all patients having a redeemed prescription of a glucose-lowering drug between 1995 and 2019 and excluded patients with a first-time redeemed prescription consisting of insulin. Within this cohort, we nested a case-control population comprising all OHCA-cases from presumed cardiac causes between 2013 and 2019. OHCA-cases were matched 1:5 to non-OHCA controls of the same sex and age on the date of OHCA. The odds ratios (ORs) and corresponding 95% confidence intervals (95%-CIs) of OHCA were reported comparing GLP-1 RAs versus DPP-4is.
Results
We identified 3,618 OHCA-cases from presumed cardiac causes and matched them to 18,090 non-OHCA controls. GLP-1 RAs were used by 269 (7.44%) cases and 1297 (7.17%) controls, and conferred no increase in the overall odds of OHCA compared with DPP-4i use (OR:0.89, 95%-CI 0.74–1.07). However, stratification according to sex revealed that OHCA risk was significantly reduced in women (OR:0.59, 95%-CI 0.40–0.86) but not in men (OR:1.01, 95%-CI 0.82–1.26, P-value interaction:0.0093). The OR of OHCA did not vary significantly when stratifying for age, duration of diabetes, chronic kidney disease, or presence of cardiovascular disease.
Conclusion
Our findings indicate that GLP-1 RA use is not associated with a reduced risk of OHCA in Danish individuals with type 2 diabetes when compared to DPP-4is.
{"title":"Glucagon-like peptide-1 receptor agonist use is associated with reduced risk of out-of-hospital cardiac arrest in women with type 2 diabetes: A nationwide nested case-control study","authors":"Talip E. Eroglu , Ruben Coronel , Fredrik Folke , Gunnar Gislason","doi":"10.1016/j.resplu.2024.100821","DOIUrl":"10.1016/j.resplu.2024.100821","url":null,"abstract":"<div><h3>Objective</h3><div>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) improve cardiovascular outcomes in patients with type 2 diabetes, but few studies have studied the risk of out-of-hospital cardiac arrest (OHCA). We investigated whether GLP-1 RA use reduce OHCA risk in type 2 diabetes when compared to dipeptidyl peptidase-4 inhibitor (DPP-4i) use.</div></div><div><h3>Methods</h3><div>We identified all patients having a redeemed prescription of a glucose-lowering drug between 1995 and 2019 and excluded patients with a first-time redeemed prescription consisting of insulin. Within this cohort, we nested a case-control population comprising all OHCA-cases from presumed cardiac causes between 2013 and 2019. OHCA-cases were matched 1:5 to non-OHCA controls of the same sex and age on the date of OHCA. The odds ratios (ORs) and corresponding 95% confidence intervals (95%-CIs) of OHCA were reported comparing GLP-1 RAs versus DPP-4is.</div></div><div><h3>Results</h3><div>We identified 3,618 OHCA-cases from presumed cardiac causes and matched them to 18,090 non-OHCA controls. GLP-1 RAs were used by 269 (7.44%) cases and 1297 (7.17%) controls, and conferred no increase in the overall odds of OHCA compared with DPP-4i use (OR:0.89, 95%-CI 0.74–1.07). However, stratification according to sex revealed that OHCA risk was significantly reduced in women (OR:0.59, 95%-CI 0.40–0.86) but not in men (OR:1.01, 95%-CI 0.82–1.26, P-value interaction:0.0093). The OR of OHCA did not vary significantly when stratifying for age, duration of diabetes, chronic kidney disease, or presence of cardiovascular disease.</div></div><div><h3>Conclusion</h3><div>Our findings indicate that GLP-1 RA use is not associated with a reduced risk of OHCA in Danish individuals with type 2 diabetes when compared to DPP-4is.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"20 ","pages":"Article 100821"},"PeriodicalIF":2.1,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
High-risk deliveries are still common due to the increased use of assisted reproductive technologies. In Japan, despite centralization of labor, about half of all deliveries are still carried out in obstetric clinics. Telemedicine support is important for neonatal resuscitation involving urgent, life-altering professional judgment in local deliveries. This feasibility study examined the effects of using medical communication software on the quality of neonatal resuscitation, and the physiological parameters of the newborn and stress of the resuscitators.
Methods
This observational study included cesarean births with ≥ 36 weeks gestational age at Kagoshima City Hospital between January 1, 2023 and 2024. A camera on the neonatal resuscitation table allowed a neonatologist to observe the resuscitation through a medical communication software and give instructions to the resuscitators. The midwife performing the resuscitation wore a communication microphone to interact with the neonatologist. Details of the neonatal resuscitation procedures, newborn physical findings, and neonatal intensive care unit (NICU) admission rates were collected from medical records. A midwife questionnaire was also administered. The primary endpoints were resuscitation findings, and the secondary endpoint was resuscitator stress before and after implementing the software.
Results
The intervention had no major adverse effects and no change in NICU admission rates; however, there were increases in post-resuscitation temperature and suctioning frequency. While the intervention caused stress to the resuscitators, it also contributed to an increased sense of security and learning.
Conclusion
Telemedicine support in neonatal resuscitation can be introduced without significant adverse effects.
{"title":"Impact of video-assisted neonatal resuscitation on newborns and resuscitators: A feasibility study","authors":"Hiroki Otsuka , Eiji Hirakawa , Asataro Yara , Daisuke Saito , Takuya Tokuhisa","doi":"10.1016/j.resplu.2024.100811","DOIUrl":"10.1016/j.resplu.2024.100811","url":null,"abstract":"<div><h3>Aim</h3><div>High-risk deliveries are still common due to the increased use of assisted reproductive technologies. In Japan, despite centralization of labor, about half of all deliveries are still carried out in obstetric clinics. Telemedicine support is important for neonatal resuscitation involving urgent, life-altering professional judgment in local deliveries. This feasibility study examined the effects of using medical communication software on the quality of neonatal resuscitation, and the physiological parameters of the newborn and stress of the resuscitators.</div></div><div><h3>Methods</h3><div>This observational study included cesarean births with ≥ 36 weeks gestational age at Kagoshima City Hospital between January 1, 2023 and 2024. A camera on the neonatal resuscitation table allowed a neonatologist to observe the resuscitation through a medical communication software and give instructions to the resuscitators. The midwife performing the resuscitation wore a communication microphone to interact with the neonatologist. Details of the neonatal resuscitation procedures, newborn physical findings, and neonatal intensive care unit (NICU) admission rates were collected from medical records. A midwife questionnaire was also administered. The primary endpoints were resuscitation findings, and the secondary endpoint was resuscitator stress before and after implementing the software.</div></div><div><h3>Results</h3><div>The intervention had no major adverse effects and no change in NICU admission rates; however, there were increases in post-resuscitation temperature and suctioning frequency. While the intervention caused stress to the resuscitators, it also contributed to an increased sense of security and learning.</div></div><div><h3>Conclusion</h3><div>Telemedicine support in neonatal resuscitation can be introduced without significant adverse effects.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"20 ","pages":"Article 100811"},"PeriodicalIF":2.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-02DOI: 10.1016/j.resplu.2024.100816
Asser M.J. Seppä , Markus B. Skrifvars , Heidi Vuopio , Rahul Raj , Matti Reinikainen , Pirkka T. Pekkarinen
Introduction
Post-resuscitation care of cardiac arrest patients may be complicated by systemic inflammation elicited in response to whole-body ischaemia–reperfusion injury. We assessed the association between early WBC with one-year mortality in a large, unselected population of cardiac arrest patients.
Methods
We collected a retrospective multicentre cohort of ICU-treated CA patients from the Finnish national ICU registry. We used locally estimated scatterplot smoothing (LOESS) curve to assess the association between the most abnormal WBC of the first 24 h in the ICU with the likelihood of death within a year. Multivariable logistic regression analyses were performed to assess the independent association between WBC and one-year mortality. In nested cohort analysis, we tested the association of delay from collapse to return of spontaneous circulation (ROSC) with WBC in linear regression models.
Results
The LOESS curve was U-shaped, with the lowest predicted mortality at 7.5 109/L WBC. Based on this cut-off value, patients were divided into high (≥ 7.5 109/L) and low (< 7.5 109/L) WBC groups. In 4229 patients with high WBC, higher WBC was independently associated with increased one-year mortality (adjusted odds ratio (OR) 1.03 per 109/L, 95 % confidence interval (CI) 1.02–1.04, p < 0.001). In 776 patients with low WBC, lower WBC was independently associated with increased one-year mortality (adjusted OR 0.88 per 109/L, 95 % CI 0.80–0.96, p < 0.001). In a nested cohort analysis, longer ROSC-delay was associated with higher WBC in patients with a shockable rhythm (β = 0.10, R2 = 0.04, p < 0.001).
Conclusions
In this large retrospective cohort, WBC was independently associated with one-year mortality after CA. Mortality was lowest in patients with WBC close to the upper limit of the normal reference range. Although WBC is not useful for outcome prognostication in individual patients, our results support the concept of excess inflammation being a harmful component of the post-cardiac arrest syndrome.
导言 心脏骤停患者复苏后的护理可能会因全身缺血再灌注损伤引起的全身炎症而变得复杂。我们评估了大量未经筛选的心脏骤停患者中早期白细胞与一年死亡率之间的关系。我们使用局部估计散点图平滑(LOESS)曲线来评估重症监护室头 24 小时白细胞最异常与一年内死亡可能性之间的关联。为评估白细胞与一年内死亡率之间的独立关联,进行了多变量逻辑回归分析。在嵌套队列分析中,我们在线性回归模型中检验了从昏迷到恢复自主循环(ROSC)的延迟与白细胞的关系。结果LOESS曲线呈U形,白细胞为7.5 109/L 时预测死亡率最低。根据这一临界值,患者被分为高白细胞组(≥ 7.5 109/L)和低白细胞组(< 7.5 109/L)。在 4229 例高白细胞患者中,白细胞越高,一年死亡率越高(调整后的几率比(OR)为 1.03 per 109/L,95 % 置信区间(CI)为 1.02-1.04,p < 0.001)。在 776 例白细胞较低的患者中,白细胞较低与一年期死亡率的增加独立相关(调整后 OR 为 0.88 per 109/L,95 % 置信区间 (CI) 为 0.80-0.96,p <0.001)。结论在这一大型回顾性队列中,WBC 与 CA 后的一年死亡率密切相关。白细胞接近正常参考范围上限的患者死亡率最低。虽然白细胞对个别患者的预后没有帮助,但我们的结果支持了炎症过多是心脏骤停后综合征的有害因素这一概念。
{"title":"Association of white blood cell count with one-year mortality after cardiac arrest","authors":"Asser M.J. Seppä , Markus B. Skrifvars , Heidi Vuopio , Rahul Raj , Matti Reinikainen , Pirkka T. Pekkarinen","doi":"10.1016/j.resplu.2024.100816","DOIUrl":"10.1016/j.resplu.2024.100816","url":null,"abstract":"<div><h3>Introduction</h3><div>Post-resuscitation care of cardiac arrest patients may be complicated by systemic inflammation elicited in response to whole-body ischaemia–reperfusion injury. We assessed the association between early WBC with one-year mortality in a large, unselected population of cardiac arrest patients.</div></div><div><h3>Methods</h3><div>We collected a retrospective multicentre cohort of ICU-treated CA patients from the Finnish national ICU registry. We used locally estimated scatterplot smoothing (LOESS) curve to assess the association between the most abnormal WBC of the first 24 h in the ICU with the likelihood of death within a year. Multivariable logistic regression analyses were performed to assess the independent association between WBC and one-year mortality. In nested cohort analysis, we tested the association of delay from collapse to return of spontaneous circulation (ROSC) with WBC in linear regression models.</div></div><div><h3>Results</h3><div>The LOESS curve was U-shaped, with the lowest predicted mortality at 7.5 10<sup>9</sup>/L WBC. Based on this cut-off value, patients were divided into high (≥ 7.5 10<sup>9</sup>/L) and low (< 7.5 10<sup>9</sup>/L) WBC groups. In 4229 patients with high WBC, higher WBC was independently associated with increased one-year mortality (adjusted odds ratio (OR) 1.03 per 10<sup>9</sup>/L, 95 % confidence interval (CI) 1.02–1.04, p < 0.001). In 776 patients with low WBC, lower WBC was independently associated with increased one-year mortality (adjusted OR 0.88 per 10<sup>9</sup>/L, 95 % CI 0.80–0.96, p < 0.001). In a nested cohort analysis, longer ROSC-delay was associated with higher WBC in patients with a shockable rhythm (β = 0.10, R<sup>2</sup> = 0.04, p < 0.001).</div></div><div><h3>Conclusions</h3><div>In this large retrospective cohort, WBC was independently associated with one-year mortality after CA. Mortality was lowest in patients with WBC close to the upper limit of the normal reference range. Although WBC is not useful for outcome prognostication in individual patients, our results support the concept of excess inflammation being a harmful component of the post-cardiac arrest syndrome.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"20 ","pages":"Article 100816"},"PeriodicalIF":2.1,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-30DOI: 10.1016/j.resplu.2024.100810
Angelo Auricchio , Tommaso Scquizzato , Federico Ravenda , Ruggero Cresta , Stefano Peluso , Maria Luce Caputo , Stefano Tonazzi , Claudio Benvenuti , Antonietta Mira
Background
Predicting the incidence of time-sensitive cardiovascular diseases like out-of-hospital cardiac arrest (OHCA), ST-elevation myocardial infarction (STEMI), and stroke can reduce time to treatment and improve outcomes. This study analysed the spatio-temporal distribution of OHCAs, STEMIs, and strokes, their spatio-temporal correlation, and the performance of different prediction algorithms.
Methods
Adults who experienced an OHCA, STEMI, or stroke in Canton Ticino, Switzerland from 2005 to 2022 were included. Datasets were divided into training and validation samples. To estimate and predict the yearly per-capita population incidences of OHCA, STEMI, and stroke, the integrated nested Laplace approximation (INLA), machine learning meta model (MLMM), the Naïve prediction method, and the exponential moving average were employed and compared. The relationship between OHCA, STEMI, and stroke was assessed by predicting the incidence of one condition, considering the lagged incidence of the other two as explanatory variables.
Results
We included 3,906 OHCAs, 2,162 STEMIs, and 2,536 stroke patients. INLA and MLMM yearly predicted incidence OHCA, STEMI, and stroke at municipality level with very high accuracy, outperforming the Naïve forecasting and the exponential moving average. INLA exhibited errors of zero or one event in 82%, 87%, and 72% of municipalities for OHCA, STEMI, and stroke, respectively, whereas ML had errors in 81%, 89%, and 71% of municipalities for the same conditions. INLA had a prediction error of 0.87, 0.77, and 1.50 events per year per municipality for OHCA, STEMI and stroke, whereas MLMM of 0.70, 0.74, and 1.09 events, respectively. Including in the INLA model the lagged absolute values of the other conditions as covariates improved the prediction of OHCA and stroke but not STEMI. MLMM predictions were consistently the most accurate and did not benefit from the inclusion of the other conditions as covariates. All the three diseases showed a similar spatial pattern.
Conclusions
Prediction of incidence of OHCA, STEMI, and stroke is possible with very high accuracy using INLA and MLMM models. A robust spatio-temporal correlation between the 3 pathologies exists. Widespread implementation in clinical practice of prediction algorithms may allow to improve resource allocation, reduce treatment delays, and improve outcomes.
{"title":"Spatio-temporal distribution, prediction and relationship of three major acute cardiovascular events: Out-of-hospital cardiac arrest, ST-elevation myocardial infarction and stroke","authors":"Angelo Auricchio , Tommaso Scquizzato , Federico Ravenda , Ruggero Cresta , Stefano Peluso , Maria Luce Caputo , Stefano Tonazzi , Claudio Benvenuti , Antonietta Mira","doi":"10.1016/j.resplu.2024.100810","DOIUrl":"10.1016/j.resplu.2024.100810","url":null,"abstract":"<div><h3>Background</h3><div>Predicting the incidence of time-sensitive cardiovascular diseases like out-of-hospital cardiac arrest (OHCA), ST-elevation myocardial infarction (STEMI), and stroke can reduce time to treatment and improve outcomes. This study analysed the spatio-temporal distribution of OHCAs, STEMIs, and strokes, their spatio-temporal correlation, and the performance of different prediction algorithms.</div></div><div><h3>Methods</h3><div>Adults who experienced an OHCA, STEMI, or stroke in Canton Ticino, Switzerland from 2005 to 2022 were included. Datasets were divided into training and validation samples. To estimate and predict the yearly per-capita population incidences of OHCA, STEMI, and stroke, the integrated nested Laplace approximation (INLA), machine learning meta model (MLMM), the Naïve prediction method, and the exponential moving average were employed and compared. The relationship between OHCA, STEMI, and stroke was assessed by predicting the incidence of one condition, considering the lagged incidence of the other two as explanatory variables.</div></div><div><h3>Results</h3><div>We included 3,906 OHCAs, 2,162 STEMIs, and 2,536 stroke patients. INLA and MLMM yearly predicted incidence OHCA, STEMI, and stroke at municipality level with very high accuracy, outperforming the Naïve forecasting and the exponential moving average. INLA exhibited errors of zero or one event in 82%, 87%, and 72% of municipalities for OHCA, STEMI, and stroke, respectively, whereas ML had errors in 81%, 89%, and 71% of municipalities for the same conditions. INLA had a prediction error of 0.87, 0.77, and 1.50 events per year per municipality for OHCA, STEMI and stroke, whereas MLMM of 0.70, 0.74, and 1.09 events, respectively. Including in the INLA model the lagged absolute values of the other conditions as covariates improved the prediction of OHCA and stroke but not STEMI. MLMM predictions were consistently the most accurate and did not benefit from the inclusion of the other conditions as covariates. All the three diseases showed a similar spatial pattern.</div></div><div><h3>Conclusions</h3><div>Prediction of incidence of OHCA, STEMI, and stroke is possible with very high accuracy using INLA and MLMM models. A robust spatio-temporal correlation between the 3 pathologies exists. Widespread implementation in clinical practice of prediction algorithms may allow to improve resource allocation, reduce treatment delays, and improve outcomes.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"20 ","pages":"Article 100810"},"PeriodicalIF":2.1,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-30DOI: 10.1016/j.resplu.2024.100818
Haruka Takahashi , Kensuke Suzuki , Yohei Okada , Satoshi Harada , Hiroyuki Yokota , Marcus Eng Hock Ong , Satoo Ogawa
Background
This study aimed to investigate the physiological load on bystanders during cardiopulmonary resuscitation (CPR) and the quality of chest compressions in hot and humid environments.
Methods
This prospective experimental study compared the physical load and quality of chest compressions among healthy volunteers who performed 10 min chest compression in a climate chamber under normal conditions (for Tokyo) (Wet Bulb Globe Temperature [WBGT] 21 °C) and hot and humid conditions (WBGT 31 °C). The primary outcome was the depth of chest compressions over a 10-minute period. Secondary outcomes included the volunteer’s heart rate (HR), core body temperature (BT), Borg scale for assessing fatigue, and blood lactate levels. Data were analyzed using two-way repeated measures analysis of variance (ANOVA) and paired t-tests.
Results
Out of 31 participants, 29 participants (mean [SD] age: 21[0.7], male: 21 [70.5 %]) were included in the analysis. For WBGT 21 °C and 31 °C, the mean chest compression depth at 10 min was not statistically difference (the depth of chest compression: 52.2 mm and 51.5 mm (p = 0.52)). At 10 min, heart rate and core temperature were 126 vs. 143 bpm, and 37.4℃ vs. 37.5℃ for WBGT 21℃ vs. WBGT 31℃ (mean differences: 17 bpm [95 % CI: 7.7–26.3], 0.1℃ [95 % CI: −0.1–0.3]). At the end, Borg scale was 16 vs. 18 and lactate levels were 3.9 vs. 5.1 mmol/L (mean differences: 2 [95 % CI: 1–3], 1.2 mmol/L [95 % CI: 0.1–2.3]).
Conclusion
there was no significant difference in the depth of chest compression of paramedic students under the conditions between WBGT 31℃ and WBGT 21℃. For secondary outcomes, the lactate and fatigue of bystanders increased under WBGT 31℃ compared to WBGT 21℃. Further research is needed on CPR in hot and humid environments.
{"title":"Evaluation of fatigue, load and the quality of chest compressions by bystanders in hot and humid environments","authors":"Haruka Takahashi , Kensuke Suzuki , Yohei Okada , Satoshi Harada , Hiroyuki Yokota , Marcus Eng Hock Ong , Satoo Ogawa","doi":"10.1016/j.resplu.2024.100818","DOIUrl":"10.1016/j.resplu.2024.100818","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate the physiological load on bystanders during cardiopulmonary resuscitation (CPR) and the quality of chest compressions in hot and humid environments.</div></div><div><h3>Methods</h3><div>This prospective experimental study compared the physical load and quality of chest compressions among healthy volunteers who performed 10 min chest compression in a climate chamber under normal conditions (for Tokyo) (Wet Bulb Globe Temperature [WBGT] 21 °C) and hot and humid conditions (WBGT 31 °C). The primary outcome was the depth of chest compressions over a 10-minute period. Secondary outcomes included the volunteer’s heart rate (HR), core body temperature (BT), Borg scale for assessing fatigue, and blood lactate levels. Data were analyzed using two-way repeated measures analysis of variance (ANOVA) and paired t-tests.</div></div><div><h3>Results</h3><div>Out of 31 participants, 29 participants (mean [SD] age: 21[0.7], male: 21 [70.5 %]) were included in the analysis. For WBGT 21 °C and 31 °C, the mean chest compression depth at 10 min was not statistically difference (the depth of chest compression: 52.2 mm and 51.5 mm (p = 0.52)). At 10 min, heart rate and core temperature were 126 vs. 143 bpm, and 37.4℃ vs. 37.5℃ for WBGT 21℃ vs. WBGT 31℃ (mean differences: 17 bpm [95 % CI: 7.7–26.3], 0.1℃ [95 % CI: −0.1–0.3]). At the end, Borg scale was 16 vs. 18 and lactate levels were 3.9 vs. 5.1 mmol/L (mean differences: 2 [95 % CI: 1–3], 1.2 mmol/L [95 % CI: 0.1–2.3]).</div></div><div><h3>Conclusion</h3><div>there was no significant difference in the depth of chest compression of paramedic students under the conditions between WBGT 31℃ and WBGT 21℃. For secondary outcomes, the lactate and fatigue of bystanders increased under WBGT 31℃ compared to WBGT 21℃. Further research is needed on CPR in hot and humid environments.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"20 ","pages":"Article 100818"},"PeriodicalIF":2.1,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-29DOI: 10.1016/j.resplu.2024.100812
Uri Adrian Prync Flato , Ricardo Ferreira Mendes de Oliveira , Lucas Kallas-Silva , Maria Fernanda Dias Azevedo
{"title":"Mirror, mirror, on the wall, who’s the fairest of them all?","authors":"Uri Adrian Prync Flato , Ricardo Ferreira Mendes de Oliveira , Lucas Kallas-Silva , Maria Fernanda Dias Azevedo","doi":"10.1016/j.resplu.2024.100812","DOIUrl":"10.1016/j.resplu.2024.100812","url":null,"abstract":"","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"20 ","pages":"Article 100812"},"PeriodicalIF":2.1,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-29DOI: 10.1016/j.resplu.2024.100815
Abel Nicolau , Ingrid Bispo , Marc Lazarovici , Christoffer Ericsson , Pedro Sa-Couto , Inês Jorge , Pedro Vieira-Marques , Carla Sa-Couto
Background
Success in resuscitation depends not only on the timeliness of the maneuvers but also on the quality of chest compressions. Factors such as the rescuer position and arm angle can significantly impact compression quality.
Aim
This study explores the influence of rescuer positioning and arm angle on the quality of chest compressions among healthcare professionals experienced in cardiopulmonary resuscitation.
Methods
In this international, multicentric, randomized crossover simulation trial with independent groups, healthcare professionals were assigned to one of four positions: kneeling on the floor, standing, standing on a step stool, and kneeling on the bed. Participants performed two 3-minute trials of uninterrupted chest compressions at arm angles of 90° and 105°. Compression quality was assessed, using manikin derived data.
Results
A total of 76 participants entered the study. Those using a 90° arm angle exhibited higher compression scores than those at a 105° angle. Rescuers standing on a step stool maintained higher scores over time when compared to other groups. In contrast, rescuers kneeling on the bed consistently scored below 75% throughout the trial, with particularly low scores at the 105° angle.
Conclusion
Rescuer position and arm angle significantly influence CPR quality, with a 90° arm angle and elevated positioning optimizing compression depth and effectiveness. The results recommend against kneeling on the bed due to its negative impact on chest compression quality.
{"title":"Influence of rescuer position and arm angle on chest compression quality: An international multicentric randomized crossover simulation trial","authors":"Abel Nicolau , Ingrid Bispo , Marc Lazarovici , Christoffer Ericsson , Pedro Sa-Couto , Inês Jorge , Pedro Vieira-Marques , Carla Sa-Couto","doi":"10.1016/j.resplu.2024.100815","DOIUrl":"10.1016/j.resplu.2024.100815","url":null,"abstract":"<div><h3>Background</h3><div>Success in resuscitation depends not only on the timeliness of the maneuvers but also on the quality of chest compressions. Factors such as the rescuer position and arm angle can significantly impact compression quality.</div></div><div><h3>Aim</h3><div>This study explores the influence of rescuer positioning and arm angle on the quality of chest compressions among healthcare professionals experienced in cardiopulmonary resuscitation.</div></div><div><h3>Methods</h3><div>In this international, multicentric, randomized crossover simulation trial with independent groups, healthcare professionals were assigned to one of four positions: kneeling on the floor, standing, standing on a step stool, and kneeling on the bed. Participants performed two 3-minute trials of uninterrupted chest compressions at arm angles of 90° and 105°. Compression quality was assessed, using manikin derived data.</div></div><div><h3>Results</h3><div>A total of 76 participants entered the study. Those using a 90° arm angle exhibited higher compression scores than those at a 105° angle. Rescuers standing on a step stool maintained higher scores over time when compared to other groups. In contrast, rescuers kneeling on the bed consistently scored below 75% throughout the trial, with particularly low scores at the 105° angle.</div></div><div><h3>Conclusion</h3><div>Rescuer position and arm angle significantly influence CPR quality, with a 90° arm angle and elevated positioning optimizing compression depth and effectiveness. The results recommend against kneeling on the bed due to its negative impact on chest compression quality.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"20 ","pages":"Article 100815"},"PeriodicalIF":2.1,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-28DOI: 10.1016/j.resplu.2024.100813
Olaf Aretz , Jana Vienna Rödler , Athina Gavriil , Marc Deussen , Emmanuel Chorianopoulos , Sebastian Bergrath
Aim
Guidelines recommend supraglottic airways (e.g. laryngeal tube, LT) for out-of-hospital cardiac arrest (OHCA) if providers are not skilled in endotracheal intubation (ETI). In prolonged cardiopulmonary resuscitation (CPR) LT led to asphyxial physiology. Therefore we evaluated the impact of LT vs. ETI on gasometry and lactate at admission.
Methods
All patients from 1 January 2020 to 30 April 2023 with return of spontaneous circulation (ROSC) or ongoing CPR (no ROSC) were included in this retrospective cohort study.
Continuous data were analysed using the Mann-Whitney-U-Test.
Results
Overall, 147 patients were included: ETI, n = 104; LT, n = 33; other airways, n = 10. ROSC, n = 86; no ROSC, n = 61. ETI vs. LT (median) for all patients showed: arterial blood gas analyses (BGA) (n = 62 vs. n = 20): pH 7.01 vs. 7.07, p = 0.83; pCO2 64.5 vs. 66.6 mmHg, p = 0.62; lactate 10.1 vs. 9.5 mmol/l, p = 0.68. Venous BGA (n = 37 vs. n = 11): pH 6.91 vs. 7.12, p = 0.15; pCO2 77.4 vs. 66.0 mmHg, p = 0.19; lactate 11.5 vs. 8.6 mmol/l, p = 0.24. ROSC, arterial BGA (n = 39 vs. n = 12): pH 7.09 vs. 7.14, p = 0.36; pCO2 60.3 vs. 56.4 mmHg, p = 0.84; lactate 8.95 vs. 7.0 mmol/l, p = 0.35. No ROSC, arterial BGA (n = 23 vs. n = 8): pH 6.9 vs. 6.8, p = 0.03; pCO2 80.7 vs. 85.6 mmHg, p = 0.64; lactate 13.0 vs. 14.6 mmol/l, p = 0.62.
Conclusion
The prehospital airway strategy had no impact on gasometry in this OHCA collective except a better pH with ETI in no ROSC. Due to small numbers and non-existent data about the exact prehospital ventilation parameters, further prospective studies are needed to evaluate this question.
如果医护人员不熟练气管插管 (ETI),《指南》建议对院外心脏骤停 (OHCA) 采用声门上气道(如喉导管,LT)。在长时间的心肺复苏(CPR)中,喉管插管会导致窒息生理。这项回顾性队列研究纳入了 2020 年 1 月 1 日至 2023 年 4 月 30 日期间自发循环恢复(ROSC)或正在进行心肺复苏(无 ROSC)的所有患者:ETI,104 人;LT,33 人;其他气道,10 人。ROSC:86人;无ROSC:61人。所有患者的 ETI 与 LT(中位数)对比显示:动脉血气分析(BGA)(n = 62 vs. n = 20):pH 7.01 vs. 7.07,p = 0.83;pCO2 64.5 vs. 66.6 mmHg,p = 0.62;乳酸 10.1 vs. 9.5 mmol/l,p = 0.68。静脉 BGA(n = 37 vs. n = 11):pH 6.91 vs. 7.12,p = 0.15;pCO2 77.4 vs. 66.0 mmHg,p = 0.19;乳酸 11.5 vs. 8.6 mmol/l,p = 0.24。ROSC,动脉 BGA(n = 39 vs. n = 12):pH 7.09 vs. 7.14,p = 0.36;pCO2 60.3 vs. 56.4 mmHg,p = 0.84;乳酸 8.95 vs. 7.0 mmol/l,p = 0.35。无 ROSC,动脉 BGA(n = 23 vs. n = 8):pH 6.9 vs. 6.8,p = 0.03;pCO2 80.7 vs. 85.6 mmHg,p = 0.64;乳酸 13.0 vs. 14.6 mmol/l,p = 0.62。由于院前通气参数的确切数据较少且不存在,因此需要进一步的前瞻性研究来评估这一问题。
{"title":"Impact of endotracheal intubation versus laryngeal tube on gasometry and lactate at emergency department admission after out-of-hospital cardiac arrest","authors":"Olaf Aretz , Jana Vienna Rödler , Athina Gavriil , Marc Deussen , Emmanuel Chorianopoulos , Sebastian Bergrath","doi":"10.1016/j.resplu.2024.100813","DOIUrl":"10.1016/j.resplu.2024.100813","url":null,"abstract":"<div><h3>Aim</h3><div>Guidelines recommend supraglottic airways (e.g. laryngeal tube, LT) for out-of-hospital cardiac arrest (OHCA) if providers are not skilled in endotracheal intubation (ETI). In prolonged cardiopulmonary resuscitation (CPR) LT led to asphyxial physiology. Therefore we evaluated the impact of LT vs. ETI on gasometry and lactate at admission.</div></div><div><h3>Methods</h3><div>All patients from 1 January 2020 to 30 April 2023 with return of spontaneous circulation (ROSC) or ongoing CPR (no ROSC) were included in this retrospective cohort study.</div><div>Continuous data were analysed using the Mann-Whitney-U-Test.</div></div><div><h3>Results</h3><div>Overall, 147 patients were included: ETI, n = 104; LT, n = 33; other airways, n = 10. ROSC, n = 86; no ROSC, n = 61. ETI vs. LT (median) for all patients showed: arterial blood gas analyses (BGA) (n = 62 vs. n = 20): pH 7.01 vs. 7.07, p = 0.83; pCO<sub>2</sub> 64.5 vs. 66.6 mmHg, p = 0.62; lactate 10.1 vs. 9.5 mmol/l, p = 0.68. Venous BGA (n = 37 vs. n = 11): pH 6.91 vs. 7.12, p = 0.15; pCO<sub>2</sub> 77.4 vs. 66.0 mmHg, p = 0.19; lactate 11.5 vs. 8.6 mmol/l, p = 0.24. ROSC, arterial BGA (n = 39 vs. n = 12): pH 7.09 vs. 7.14, p = 0.36; pCO<sub>2</sub> 60.3 vs. 56.4 mmHg, p = 0.84; lactate 8.95 vs. 7.0 mmol/l, p = 0.35. No ROSC, arterial BGA (n = 23 vs. n = 8): pH 6.9 vs. 6.8, p = 0.03; pCO<sub>2</sub> 80.7 vs. 85.6 mmHg, p = 0.64; lactate 13.0 vs. 14.6 mmol/l, p = 0.62.</div></div><div><h3>Conclusion</h3><div>The prehospital airway strategy had no impact on gasometry in this OHCA collective except a better pH with ETI in no ROSC. Due to small numbers and non-existent data about the exact prehospital ventilation parameters, further prospective studies are needed to evaluate this question.</div></div>","PeriodicalId":94192,"journal":{"name":"Resuscitation plus","volume":"20 ","pages":"Article 100813"},"PeriodicalIF":2.1,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142537661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}