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Intranasal Delivery of Medications for the Treatment of Neurologic Conditions: A Pharmacology Update. 鼻内给药治疗神经系统疾病:药理学更新。
Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI: 10.1097/JNN.0000000000000769
Patricia Osborne Shafer, Patricia Dean, Lai Brooks, Barry Gidal, Sunita N Misra, Enrique Carrazana

Abstract: INTRODUCTION: Nurses have a central role in educating patients and families about treatment options and how to integrate them into action plans for neurologic conditions. In recent years, a growing number of intranasal formulations have become available as rescue therapy for neurologic conditions or symptoms including migraine, opioid overdose, and seizures. Rescue therapies do not replace maintenance medications or emergency care but are designed to enable rapid treatment of urgent or disabling conditions in community settings. Yet, discussion of rescue therapies for neurologic conditions remains limited in nursing literature. CONTENT: Intranasal formulations are specifically formulated for delivery and absorption in the nose and have several characteristics that are well suited as rescue therapies for neurologic conditions. Intranasal formulations include triptans for migraine, naloxone and nalmefene for opioid overdose, and benzodiazepines for seizure clusters in patients with epilepsy. Therapeutic attributes discussed here include ease of use in community settings by nonmedical professionals, relatively rapid onset of action, and favorable safety profile and patient experience. This information is critical for nurses to make informed decisions about rescue therapy options, incorporate these into plans of care, and educate patients, care partners, and other healthcare providers. CONCLUSION: Rescue therapies are increasingly important in the care of people with neurologic conditions. Various formulations are available and continue to evolve, offering easy and quick ways for nurses, patients, and nonmedical care partners to administer critical rescue medications. For nurses overseeing medication management, the attributes of intranasal rescue therapies should be considered in the context of providing patients with the right care at the right time.

摘要:引言:护士在教育患者和家属了解治疗方案以及如何将这些方案纳入神经系统疾病的行动计划方面发挥着核心作用。近年来,越来越多的鼻内制剂可作为神经系统疾病或症状(包括偏头痛、阿片类药物过量和癫痫发作)的抢救疗法。抢救疗法并不能取代维持用药或急救护理,而是为了在社区环境中快速治疗紧急或致残性疾病。然而,护理文献中对神经系统疾病抢救疗法的讨论仍然有限。内容:鼻内制剂是专为鼻腔给药和吸收而配制的,具有非常适合作为神经系统疾病抢救疗法的几个特点。鼻内制剂包括治疗偏头痛的曲坦类药物、治疗阿片类药物过量的纳洛酮和纳美芬,以及治疗癫痫患者发作群的苯二氮卓类药物。本文讨论的治疗特性包括:非医疗专业人员在社区环境中使用方便、起效相对较快、安全性和患者体验良好。这些信息对于护士做出有关抢救疗法选择的明智决定、将其纳入护理计划以及教育患者、护理伙伴和其他医疗服务提供者至关重要。结论:抢救疗法在神经系统疾病患者的护理中越来越重要。目前有多种配方可供选择,而且还在不断发展,为护士、患者和非医疗护理伙伴提供了方便快捷的关键抢救用药方法。对于负责用药管理的护士来说,在为患者提供及时正确的护理时应考虑到鼻内抢救疗法的特性。
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引用次数: 0
Neuroscience Nursing Orientation. 神经科学护理方向。
Pub Date : 2024-08-01 Epub Date: 2024-05-24 DOI: 10.1097/JNN.0000000000000761
Salomé M Loera, Holly Wirth
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引用次数: 0
Bowel Management in the Acute Phase of Spinal Cord Injury. 脊髓损伤急性期的肠道管理。
Pub Date : 2024-08-01 Epub Date: 2024-05-31 DOI: 10.1097/JNN.0000000000000762
Elizabeth Plante, Lori Rhudy

Abstract: BACKGROUND: Neurogenic bowel and bladder are well-known complications of spinal cord injury. During the acute phase of recovery from spinal cord injury, spinal shock occurs, resulting in loss of reflexes and peristalsis of the gastrointestinal tract. These impairments can result in complications in the gastrointestinal tract and, secondarily, the respiratory system due to the distention of the abdomen. Current guidelines for bowel management target the chronic phase of spinal cord injury after a diagnosis of neurogenic bowel dysfunction can be made. METHODS: The purpose of this literature review was to determine evidence-based recommendations for bowel management during the acute phase of spinal cord injury. A systematic search using the databases CINAHL, PubMed, Cochrane Library, and ProQuest was used to identify relevant evidence. RESULTS: The available evidence is based on expert consensus, is dated, and tends to be based on studies conducted during the chronic phase of injury. Careful assessment of the symptoms of bowel dysfunction would indicate that during the acute phase of spinal cord injury, spinal shock causes a patient to experience an areflexive bowel pattern where bowel motility is limited and reflexes are absent. Management of areflexive bowel includes establishment of a daily bowel program including manual removal of stool. To improve emptying of stool, factors such as rectal and oral medications, fluid, fiber, and activity may be adjusted according to need. CONCLUSION: There is limited evidence focused specifically on bowel management in the acute phase of spinal cord injury. Bowel management is complex and multifaceted and needs to be individualized to the patient as well as frequently reevaluated with changes in condition. Further research is needed to evaluate outcomes for bowel management in the acute phase of spinal cord injury to promote best practices.

摘要:背景:神经源性肠道和膀胱是众所周知的脊髓损伤并发症。在脊髓损伤恢复的急性期,脊髓休克会导致胃肠道反射和蠕动功能丧失。这些损伤会导致胃肠道并发症,其次还会因腹部胀气而导致呼吸系统并发症。目前的肠道管理指南针对的是诊断出神经源性肠道功能障碍后的脊髓损伤慢性期。方法:本文献综述旨在确定脊髓损伤急性期肠道管理的循证建议。我们使用 CINAHL、PubMed、Cochrane Library 和 ProQuest 等数据库进行了系统检索,以确定相关证据。结果:现有证据均基于专家共识,年代久远,且多以损伤慢性期的研究为基础。对肠道功能障碍症状的仔细评估表明,在脊髓损伤的急性期,脊髓休克会导致患者出现肠道运动受限和反射消失的无反射性排便模式。无反射性排便的处理方法包括制定每日排便计划,包括人工清除粪便。为改善粪便排空,可根据需要调整直肠和口服药物、液体、纤维和活动等因素。结论:专门针对脊髓损伤急性期肠道管理的证据有限。肠道管理是复杂的、多方面的,需要根据患者的具体情况而定,并随着病情的变化经常进行重新评估。需要进一步研究评估脊髓损伤急性期肠道管理的结果,以推广最佳实践。
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引用次数: 0
A Crucial Step Forward in Implementing Early Mobility Protocols for Stroke Care. 为中风护理实施早期移动方案迈出关键一步。
Pub Date : 2024-08-01 Epub Date: 2024-05-31 DOI: 10.1097/JNN.0000000000000764
Rosa Hart, Lindsey Siewert
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引用次数: 0
Reporting on Neurological Decline as Identified by Hourly Neuroassessments. 报告每小时神经评估发现的神经功能衰退情况。
Pub Date : 2024-08-01 Epub Date: 2024-05-31 DOI: 10.1097/JNN.0000000000000765
Marcus Brazel, Jennifer Harris, Dawn Carroll, Judy Davidson, Philip J Levchak, Atul Malhotra, Jamie Nicole LaBuzetta

Abstract: BACKGROUND: Hourly neurological examinations (neuro exam) have been widely used to monitor for a decline in neurological status, allowing for timely intervention. There are, however, limited data behind this common practice. The objective of this study was to identify how frequently neurological decline occurred across various diagnoses and whether that decline (1) was identified by a scheduled neurocheck and (2) altered management. METHODS: A cross-sectional survey was performed in a neurological intensive care unit at a tertiary care academic medical center. Clinical neuroscience nurses caring for patients with hourly neurological assessments completed a brief survey at 12-hour shift completion. RESULTS: Data were collected from 212 nurse's shifts. Neurological changes were identified by nurses in 14% (n = 30) of shifts. The neurological change was identified during a scheduled neurocheck 67% of the time, with the detection of changes more likely to occur during a scheduled neuro exam than at other times ( P < .05). There was no change to the care plan in 55% of the cases of neurological decline. Patients with subarachnoid hemorrhage were more likely to have a decline detected. CONCLUSION: Findings suggest that many patients undergo hourly neurological exams without ever identifying a neurological deterioration. In many instances of neurodeterioration, there was no change to the treatment plan pursued. Primary diagnoses and neurological changes may not be entirely independent, and therefore, hourly neuro exams may have greater yield in some diagnoses than others. Replication is warranted with a larger sample to evaluate the risks and benefits of neuroassessments.

摘要:背景:每小时一次的神经系统检查(神经检查)已被广泛用于监测神经系统状态的下降,以便及时采取干预措施。然而,这一普遍做法背后的数据却很有限。本研究旨在确定神经功能衰退在各种诊断中的发生频率,以及这种衰退是否(1)通过定时神经检查发现,以及(2)改变了治疗方案。方法:在一家三级医疗学术中心的神经重症监护病房进行了一项横断面调查。负责对患者进行每小时神经系统评估的临床神经科学护士在 12 小时轮班结束时填写一份简短的调查表。结果:共收集了 212 个护士班次的数据。14%(n = 30)的轮班护士发现了神经系统变化。67%的神经系统变化是在预定的神经检查中发现的,与其他时间相比,在预定的神经检查中发现变化的可能性更大(P < .05)。55%的神经功能衰退病例没有改变护理计划。蛛网膜下腔出血患者更有可能被发现病情恶化。结论:研究结果表明,许多患者在接受每小时一次的神经系统检查时,从未发现神经系统功能衰退。在许多神经功能衰退的病例中,所采取的治疗方案并没有改变。主要诊断和神经系统变化可能并不完全独立,因此,每小时一次的神经系统检查在某些诊断中可能比在其他诊断中更有效。我们有必要在更大的样本中进行重复,以评估神经评估的风险和益处。
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引用次数: 0
Back to Basics: Is Basic Good Enough? 回归基本:基本够好吗?
Pub Date : 2024-08-01 Epub Date: 2024-04-29 DOI: 10.1097/JNN.0000000000000760
Lori M Rhudy
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引用次数: 0
Book Review: Anatomic Basis of Neurologic Diagnosis. 书评:神经学诊断的解剖学基础》。
Tiffany O Sheehan, Margaret Olsen
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引用次数: 0
Letter to the Editor: Considering Poststroke Fatigue. 致编辑的信:考虑中风后疲劳。
Pub Date : 2024-05-01 Epub Date: 2024-03-07 DOI: 10.1097/JNN.0000000000000752
Hilalnur Küçükakgün, Zeliha Tulek, Kimya Kılıçaslan, Jbid Dursun Uncu, Ceren Bayrak, Roya Soltanalizadeh, Yakup Krespi
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引用次数: 0
A Cross-sectional Survey of Comprehension and Satisfaction of Spanish-Reading Adults Regarding RÁPIDO as a Stroke Awareness Acronym. 关于阅读西班牙语的成年人对 RÁPIDO 作为脑卒中认知缩写的理解和满意度的横断面调查。
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引用次数: 0
Implementing a Critical Thinking Tool to Evaluate Educational Needs for Inpatient Rehabilitation Nurses. 采用批判性思维工具评估住院康复护士的教育需求。
Pub Date : 2024-05-01 Epub Date: 2024-02-07 DOI: 10.1097/JNN.0000000000000749
Cynthia Hill, Sonja E Stutzman, Emerson B Nairon, Ayushi Vashisht, DaiWai M Olson

Abstract: BACKGROUND: Most critical thinking assessment tools are resource intensive and require significant time and money to administer. Moreover, these tools are not tailored to evaluate critical thinking skills among inpatient rehabilitation facility (IRF) nurses. This pilot study explores the efficacy of using short videos to evaluate critical thinking for nurses working in an IRF. METHODS: We developed and filmed 3 clinical scenarios representative of common IRF events that require critical thinking on behalf of the nurse. Thirty-one IRF nurses participated in the study and independently scored their own critical thinking skills using a visual analog scale. Using the same scale, nurse managers and assistant managers who worked closely with the nurses also rated the critical thinking ability of each nurse. The nurse then viewed and responded in narrative form to each of the 3 videos. A scoring rubric was used to independently evaluate the critical thinking skills for each nurse based on the nurses' responses. RESULTS: Nurses rated their own critical thinking skills higher than mangers rated them (m = 85.23 vs 62.89). There was high interrater reliability for scoring video 1k (0.65), video 2k (0.90), and video 3k (0.84). CONCLUSION: The results demonstrate efficacy for further study of low-cost alternatives to evaluate critical thinking among neuroscience nurses providing IRF care.

摘要:背景:大多数批判性思维评估工具都是资源密集型的,需要花费大量的时间和金钱来管理。此外,这些工具并不适合评估住院康复设施(IRF)护士的批判性思维能力。本试验性研究探讨了使用短视频评估在 IRF 工作的护士批判性思维的效果。方法:我们开发并拍摄了 3 个临床场景,这些场景代表了需要护士进行批判性思维的常见 IRF 事件。31 名 IRF 护士参与了这项研究,并使用视觉模拟量表对自己的批判性思维能力进行了独立评分。与护士密切合作的护士长和经理助理也使用相同的量表对每位护士的批判性思维能力进行评分。然后,护士分别观看 3 段视频,并以叙述的形式做出回答。根据护士的回答,使用评分标准对每位护士的批判性思维能力进行独立评估。结果:护士对自己批判性思维能力的评分高于管理人员的评分(m = 85.23 vs 62.89)。对视频 1k(0.65)、视频 2k(0.90)和视频 3k(0.84)进行评分的相互间可靠性很高。结论:研究结果表明,进一步研究低成本替代方法对提供 IRF 护理的神经科学护士的批判性思维进行评估是有效的。
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The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses
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