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Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions. 领航加拿大老年转化科学:对当前进展和未来方向的全面评估》。
Guy Hajj-Boutros, Andréa Faust, John Muscedere, Perry Kim, Naji Abumrad, Stéphanie Chevalier, Mylene Aubertin-Leheudre, Howard Bergman, Dawn Bowdish, Jessica Burford, Stacy Carrington-Lawrence, Hélène Côté, David E Dawe, Philipe de Souto Barreto, Colin Farrelly, Robert Fowler, Gilles Gouspillou, Lea Harrington, Sofie Lautrup, Susan Howlett, Mahdi Imani, James Kirkland, George Kuchel, Frédérick A Mallette, José A Morais, John C Newman, Daryl Pullman, Felipe Sierra, Jeremy Van Raamsdonk, Jennifer Watt, Rebecca Jane Rylett, Gustavo Duque

The inaugural Canadian Conferences on Translational Geroscience were held as 2 complementary sessions in October and November 2023. The conferences explored the profound interplay between the biology of aging, social determinants of health, the potential societal impact of geroscience, and the maintenance of health in aging individuals. Although topics such as cellular senescence, molecular and genetic determinants of aging, and prevention of chronic disease were addressed, the conferences went on to emphasize practical applications for enhancing older people's quality of life. This article summarizes the proceeding and underscores the synergy between clinical and fundamental studies. Future directions highlight national and global collaborations and the crucial integration of early-career investigators. This work charts a course for a national framework for continued innovation and advancement in translational geroscience in Canada.

首届加拿大老年转化科学会议于 2023 年 10 月和 11 月举行,是两个互补的会议。会议探讨了衰老生物学、健康的社会决定因素、老年科学的潜在社会影响以及衰老个体的健康维护之间的深刻相互作用。虽然会议讨论了细胞衰老、老龄化的分子和遗传决定因素以及慢性疾病预防等主题,但会议接着强调了提高老年人生活质量的实际应用。本手稿对会议进行了总结,并强调了临床和基础研究之间的协同作用。未来的发展方向突出了国家和全球合作以及早期研究人员的重要整合。这项工作为加拿大地质科学转化领域的持续创新和进步制定了国家框架。
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引用次数: 0
Differences in Daily Physical Activity by Alzheimer's Risk Markers Among Older Adults. 按阿尔茨海默氏症风险指标划分的老年人日常体育活动差异。
Francesca R Marino, Jennifer A Deal, Ryan J Dougherty, Murat Bilgel, Qu Tian, Yang An, Eleanor M Simonsick, Susan M Resnick, Luigi Ferrucci, Adam P Spira, Amal A Wanigatunga, Jennifer A Schrack

Background: Daily physical activity patterns differ by Alzheimer's disease (AD) status and might signal cognitive risk. It is critical to understand whether patterns are disrupted early in the AD pathological process. Yet, whether established AD risk markers (β-amyloid [Aβ] or apolipoprotein E-ε4 [APOE-ε4]) are associated with differences in objectively measured activity patterns among cognitively unimpaired older adults is unclear.

Methods: Wrist accelerometry, brain Aβ (+/-), and APOE-ε4 genotype were collected in 106 (Aβ) and 472 (APOE-ε4) participants (mean age 76 [standard deviation{SD}: 8.5) or 75 [SD: 9.2] years, 60% or 58% women) in the Baltimore Longitudinal Study of Aging. Adjusted linear and function-on-scalar regression models examined whether Aβ or APOE-ε4 status was cross-sectionally associated with activity patterns (amount, variability, or fragmentation) overall and by time of day, respectively. Differences in activity patterns by combinations of Aβ and APOE-ε4 status were descriptively examined (n = 105).

Results: There were no differences in any activity pattern by Aβ or APOE-ε4 status overall. Aβ+ was associated with lower total amount and lower within-day variability of physical activity overnight and early evening, and APOE-ε4 carriers had higher total amount of activity in the evening and lower within-day variability of activity in the morning. Diurnal curves of activity were blunted among those with Aβ+ regardless of APOE-ε4 status, but only when including older adults with mild cognitive impairment/dementia.

Conclusions: Aβ+ in cognitively unimpaired older adults might manifest as lower amount and variability of daily physical activity, particularly during overnight/evening hours. Future research is needed to examine changes in activity patterns in larger samples and by other AD biomarkers.

背景:阿尔茨海默病(AD)患者的日常体力活动模式各不相同,可能预示着认知风险。了解运动模式是否在阿尔茨海默病病理过程的早期被破坏至关重要。然而,既有的阿尔茨海默病风险标志物(β-淀粉样蛋白(Aβ)或APOE-ε4)是否与认知功能未受损的老年人客观测量的活动模式差异有关,目前尚不清楚:在 BLSA 中收集了 106 名(Aβ)和 472 名(APOE-ε4)参与者[平均年龄为 76(SD:8.5)岁或 75(SD:9.2)岁,女性占 60% 或 58%]的腕加速度、脑 Aβ(+/-)和 APOE-ε4 基因型。调整后的线性回归模型和梯度函数回归模型分别检验了 Aβ 或 APOE-ε4 状态是否与总体活动模式(量、可变性或碎片化)以及按时间段划分的活动模式存在横截面关联。对Aβ和APOE-ε4状态组合的活动模式差异进行了描述性研究(n=105):结果:Aβ或APOE-ε4状态对任何活动模式都没有影响。Aβ+与夜间和傍晚较低的体力活动总量和较低的日内变异性有关,而APOE-ε4携带者傍晚的活动总量较高,早晨的活动日内变异性较低。无论APOE-ε4的状态如何,Aβ+携带者的昼夜活动曲线都会变钝,但只有当包括患有MCI/痴呆症的老年人时才会如此:结论:认知功能未受损的老年人中的 Aβ+ 可能表现为日常体力活动量和变化较少,尤其是在夜间/傍晚时段。未来的研究需要在更大的样本中并通过其他注意力缺失症生物标志物来研究活动模式的变化。
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引用次数: 0
Response to Letter to the Editor. 回应致编辑的信。
Scott R Bauer, Marvin E Langston, Luigi Ferrucci, Eleanor M Simonsick
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引用次数: 0
Associations of Lower Extremity Muscle Strength, Area, and Specific Force With Lower Urinary Tract Symptoms in Older Men: The Baltimore Longitudinal Study of Aging. 老年男性下肢肌肉力量、面积和特定力量与下尿路症状的关系:巴尔的摩老龄化纵向研究。
Marvin E Langston, Peggy M Cawthon, Kaiwei Lu, Rebecca Scherzer, John C Newman, Kenneth Covinsky, Luigi Ferrucci, Eleanor M Simonsick, Scott R Bauer

Background: Lower urinary tract symptoms (LUTS) in older men are associated with an increased risk of mobility limitations. Lower extremity muscle quality may represent a novel shared mechanism of both LUTS and mobility limitations.

Methods: We evaluated associations of thigh skeletal muscle measures (strength, area, and specific force) with total LUTS severity (American Urologic Association Symptom Index; AUASI) and voiding and storage subscores among 352 men aged ≥60 years enrolled in the Baltimore Longitudinal Study of Aging. Thigh muscle strength (Nm) was defined as maximum concentric 30°/s knee extensor torque, area (cm2), and specific force (Nm/cm2) defined as strength/area. Associations with AUASI score were estimated using multivariable linear regression and linear mixed models.

Results: Mean thigh muscle strength at baseline was 139.7Nm. In cross-sectional multivariable models, each 39Nm increment in thigh muscle strength and 0.28Nm/cm2 increment in specific force was associated with -1.17 point (95% CI: -1.93 to -.41) and -0.95 point (95% CI: -1.63 to -0.27) lower AUASI score, respectively. Similar associations were observed for voiding and storage subscores, although somewhat attenuated. In longitudinal analyses, baseline muscle measures were not associated with annual change in AUASI, and current changes in muscle measures and AUASI were unrelated.

Conclusions: Cross-sectionally, higher thigh muscle strength and specific force were associated with decreased LUTS severity in older men. However, we did not observe concurrent worsening LUTS severity with declining thigh muscle strength, area, or specific force in longitudinal analyses.

背景:老年男性的下尿路症状(LUTS)与行动不便的风险增加有关。下肢肌肉质量可能是导致下尿路症状和行动不便的一个新的共同机制:我们评估了巴尔的摩老龄化纵向研究(Baltimore Longitudinal Study of Aging)中 352 名年龄≥60 岁男性的大腿骨骼肌测量指标(力量、面积和比力)与 LUTS 总严重程度(美国泌尿协会症状指数 AUASI)以及排尿和储尿子分数之间的关系。大腿肌肉力量(牛顿米)定义为最大同心30°/秒膝关节伸肌扭矩、面积(平方厘米)和比力(牛顿米/平方厘米),定义为力量/面积。使用多变量线性回归和线性混合模型估计了与 AUASI 评分的关系:结果:基线时的平均大腿肌肉力量为 139.7 牛米。在横断面多变量模型中,大腿肌力每增加 39Nm 和比肌力每增加 0.28Nm/cm2 分别与 AUASI 评分降低-1.17 分(95%CI -1.93, -0.41)和-0.95 分(95%CI -1.63, -0.27)有关。在排尿和储尿子评分中也观察到了类似的关联,但有所减弱。在纵向分析中,基线肌肉测量值与 AUASI 的年度变化无关,当前肌肉测量值的变化与 AUASI 无关:横截面来看,大腿肌肉力量和比肌力的提高与老年男性尿失禁严重程度的降低有关。然而,在纵向分析中,我们并未观察到LUTS严重程度的恶化与大腿肌肉力量、面积或比肌力的下降同时发生。
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引用次数: 0
Aging-Related Mitochondrial Dysfunction Is Associated With Fibrosis in Benign Prostatic Hyperplasia. 衰老相关的线粒体功能障碍与良性前列腺增生的纤维化有关。
Alexis E Adrian, Teresa T Liu, Laura E Pascal, Scott R Bauer, Donald B DeFranco, William A Ricke

Background: Age is the greatest risk factor for lower urinary tract symptoms attributed to benign prostatic hyperplasia (LUTS/BPH). Although LUTS/BPH can be managed with pharmacotherapy, treatment failure has been putatively attributed to numerous pathological features of BPH (eg, prostatic fibrosis, inflammation). Mitochondrial dysfunction is a hallmark of aging; however, its impact on the pathological features of BPH remains unknown.

Methods: Publicly available gene array data were analyzed. Immunohistochemistry examined mitochondrial proteins in the human prostate. The effect of complex I inhibition (rotenone) on a prostatic cell line was examined using quantitative polymerase chain reaction, immunocytochemistry, and Seahorse assays. Oleic acid (OA) was tested as a bypass of complex I inhibition. Aged mice were treated with OA to examine its effects on urinary dysfunction. Voiding was assessed longitudinally, and a critical complex I protein measured.

Results: Mitochondrial function and fibrosis genes were altered in BPH. Essential mitochondrial proteins (ie, voltage-dependent anion channels 1 and 2, PTEN-induced kinase 1, and NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [NDUFS3]) were significantly (p < .05) decreased in BPH. Complex I inhibition in cultured cells resulted in decreased respiration, altered NDUFS3 expression, increased collagen deposition, and gene expression. OA ameliorated these effects. OA-treated aged mice had significantly (p < .05) improved voiding function and higher prostatic NDUFS3 expression.

Conclusions: Complex I dysfunction is a potential contributor to fibrosis and lower urinary tract dysfunction in aged mice. OA partially bypasses complex I inhibition and therefore should be further investigated as a mitochondrial modulator for treatment of LUTS/BPH. Hypotheses generated in this investigation offer a heretofore unexplored cellular target of interest for the management of LUTS/BPH.

背景:年龄是良性前列腺增生(LUTS/BPH)引起下尿路症状的最大危险因素。虽然LUTS/BHP可以通过药物治疗来控制,但治疗失败被认为是由于BPH的许多病理特征(如前列腺纤维化、炎症)。线粒体功能障碍是衰老的标志,但其对前列腺增生病理特征的影响尚不清楚。方法:对公开的基因阵列数据进行分析。免疫组织化学检测了人类前列腺中的线粒体蛋白。使用qPCR、免疫细胞化学和海马分析检测复合物I抑制(鱼藤酮)对前列腺细胞系的影响。油酸被测试为复合物I抑制的旁路。用OA治疗老年小鼠,以检查其对尿功能障碍的影响。对空隙进行纵向评估,并测量关键复合物I蛋白。结果:前列腺增生患者线粒体功能和纤维化基因发生改变。线粒体必需蛋白(即VDAC1/2、PINK1和NDUFS3)(结论:复合物I功能障碍是老年小鼠纤维化和下尿路功能障碍的潜在原因。油酸部分绕过复合物I抑制,因此应作为治疗LUTS/BPH的线粒体调节剂进行进一步研究。本研究中产生的假设为治疗LUTS/BPH提供了一个迄今为止尚未探索的细胞靶点LUTS/BPH。
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引用次数: 0
Urinary Incontinence and Voiding Dysfunction with Aging: A Multifaceted Geriatric Syndrome in Search of Multidisciplinary Research Solutions. 老年尿失禁和排尿功能障碍:寻找多学科研究解决方案的多方面老年综合症》。
George A Kuchel
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引用次数: 0
Predictors of Urinary and Fecal Incontinence in Prefrail and Frail Older Adults: A Cross-Sectional Study of the FRAGSALUD Project. 虚弱前期和虚弱老年人大小便失禁的预测因素:FRAGSALUD 项目的横断面研究。
Juan Corral-Pérez, Laura Ávila-Cabeza-de-Vaca, Inmaculada Valero-Cantero, Andrea González-Mariscal, Jesus G Ponce-Gonzalez, María Ángeles Vázquez-Sánchez, Cristina Casals

Background: Frailty is associated with urinary and fecal incontinence, which are common geriatric syndromes. This study aims to identify health factors associated with incontinence in prefrail or frail older adults living in the community.

Methods: This multicenter cross-sectional study included 225 older adults (75.0 ± 6.4 years) with prefrailty or frailty based on the 5-component Fried phenotype. Physical function was assessed using the Short Physical Performance Battery (SPPB). Physical activity, inactivity, and sleep were estimated using a wrist-worn accelerometer. Urinary or fecal incontinence was registered using the Barthel scale (urine and bowel items). Multivariable logistic regression analyses, with age as a covariate, were conducted to identify associations of incontinence.

Results: In our participants, 27% presented urinary or fecal incontinence with no sex differences (p = .266). Our results showed that age, daily medication count, and number of falls in the previous year independently predicted incontinence in frail and prefrail older adults (p < .05). Some Fried's criteria, including self-reported exhaustion, gait speed, and handgrip strength, were associated with the presence of incontinence (p < .05), but not Fried's classification. The SPPB total score and its isolated variables were significantly associated with the urinary and fecal incontinence (p < .05). However, none of the accelerometer outcomes showed significant associations with incontinence status.

Conclusions: According to this study, age, number of medications, and falls (but not sex) are linked to urinary and fecal incontinence in frail or prefrail older adults living in the community, recommending the assessment of physical function using the SPPB rather than estimating daily physical activity, inactivity, or sleep.

背景:虚弱与大小便失禁有关,而大小便失禁是常见的老年综合症。本研究旨在确定与生活在社区的前期虚弱或虚弱老年人尿失禁相关的健康因素:这项多中心横断面研究纳入了 225 名老年人(75.0±6.4 岁),他们都是根据弗里德五项表型确定的虚弱前期或虚弱老年人。身体功能采用短期体能测试(SPPB)进行评估。体力活动、缺乏活动和睡眠情况通过腕戴式加速度计进行评估。使用巴特尔量表(小便和大便项目)记录尿失禁或大便失禁情况。以年龄作为协变量,进行了多变量逻辑回归分析,以确定尿失禁的相关性:我们的参与者中有 27% 出现尿失禁或大便失禁,无性别差异(P=0.266)。我们的研究结果表明,年龄、每日用药次数和上一年跌倒次数可独立预测体弱和未老先衰老年人的尿失禁情况(PC结论:根据本研究,年龄、每日用药次数和上一年跌倒次数可独立预测体弱和未老先衰老年人的尿失禁情况:根据这项研究,年龄、用药次数和跌倒次数(而非性别)与社区中体弱或未老先衰老年人的大小便失禁有关,因此建议使用 SPPB 评估身体功能,而不是估算每天的体力活动、不活动或睡眠情况。
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引用次数: 0
Age-Dependent Effects of Voluntary Wheel Running Exercise on Voiding Behavior and Potential Age-Related Molecular Mechanisms in Mice. 小鼠自主轮跑运动对排尿行为的年龄依赖效应及潜在的年龄相关分子机制
Teresa T Liu, Laura E Pascal, Scott R Bauer, Hannah N Miles, Jules B Panksepp, Granville L Lloyd, Lingjun Li, Donald B DeFranco, William A Ricke

Background: Older men frequently develop lower urinary tract symptoms attributed to benign prostatic hyperplasia (LUTS/BPH). Risk factors for LUTS/BPH include sedentary lifestyle, anxiety/depression, obesity, and frailty, which all increase with age. Although physical exercise may reduce the progression and/or severity of LUTS/BPH, the age-related mechanisms responsible remain unknown.

Methods: Voiding symptoms, body mass, and frailty were assessed after 4-weeks of voluntary wheel running in 2-month (n = 10) and 24-month (n = 8) old C57Bl/6J male mice. In addition, various social and individual behaviors were examined in these cohorts. Finally, cellular and molecular markers of inflammation and mitochondrial protein expression were assessed in prostate tissue and systemically.

Results: Despite running less (aged vs young X¯ = 12.3 vs 30.6 km/week; p = .04), aged mice had reduced voiding symptoms (X¯ = 67.3 vs 23.7; p < .0001) after 1 week of exercise, which was sustained through week 4 (X¯ = 67.3 vs 21.5; p < .0001). Exercise did not affect voiding symptoms in young mice. Exercise also increased mobility and decreased anxiety in both young and aged mice (p < .05). Exercise decreased expression of a key mitochondrial protein (PINK1; p < .05) and inflammation within the prostate (CD68; p < .05 and plasminogen activator inhibitor-1; p < .05) and in the serum (p < .05). However, a frailty index (X¯ = 0.17 vs 0.15; p = .46) and grip strength (X¯ = 1.10 vs 1.19; p = .24) were unchanged after 4 weeks of exercise in aged mice.

Conclusions: Voluntary aerobic exercise improves voiding behavior and mobility, and decreases prostatic mitochondrial protein expression and inflammation in aged mice. This promising model could be used to evaluate molecular mechanisms of aerobic exercise as a novel lifestyle intervention for older men with LUTS/BPH.

背景:老年男性经常会因良性前列腺增生症(LUTS/BPH)而出现下尿路症状。LUTS/BPH的风险因素包括久坐不动的生活方式、焦虑/抑郁、肥胖和虚弱,这些因素都会随着年龄的增长而增加。虽然体育锻炼可以减少 LUTS/BPH 的发展和/或严重程度,但与年龄相关的机制仍不清楚:方法:对2个月大(10只)和24个月大(8只)的C57Bl/6J雄性小鼠进行为期4周的自愿轮跑后,对排尿症状、体重和虚弱程度进行了评估。此外,还对这些小鼠的各种社会和个人行为进行了检测。最后,对前列腺组织和全身的炎症和线粒体蛋白表达的细胞和分子标记进行了评估:结果:尽管老年小鼠的跑步次数较少(X̄=12.3 vs 30.6km/周;P=0.04),但其排尿症状却有所减轻(X̄=67.3 vs 23.7;PC结论:自愿有氧运动可改善排尿症状:自愿有氧运动可改善老年小鼠的排尿行为和活动能力,并减少前列腺线粒体蛋白的表达和炎症。这一前景广阔的模型可用于评估有氧运动作为一种新型生活方式干预老年男性尿失禁/前列腺增生症的分子机制。
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引用次数: 0
Life-History Trade-Offs in Drosophila: Flies Select a Diet to Maximize Reproduction at the Expense of Lifespan. 果蝇的生活史权衡:果蝇选择饮食以最大限度地繁殖为代价。
Olha Strilbytska, Ihor Yurkevych, Uliana Semaniuk, Dmytro Gospodaryov, Stephen J Simpson, Oleh Lushchak

Macronutrient intake impacts physiology, behavior, and gene expression in a wide range of organisms. We used the response surface methodology to compare how life history traits, lifespan, and reproduction differ as a function of protein and carbohydrate intakes under choice and no-choice feeding regimens in the fruit fly, Drosophila melanogaster. We found that when offered a choice of nutritionally complementary foods mated female flies regulated toward a protein to carbohydrate ratio (P:C) that was associated with shortened lifespan and maximal egg production when compared to response surfaces derived from flies fed 1 of a range of fixed diets differing in P:C (no-choice regimen). This difference in lifespan between choice and no-choice feeding was not seen in males or virgin flies, reflecting the fact that increased protein intake is triggered by mating to support egg production. However, whereas in mated females a higher P:C intake was associated with greater egg production under both choice and no-choice feeding, contrary to expectations, choice-fed mated flies laid fewer eggs than no-choice flies on equivalent macronutrient intakes, perhaps reflecting that they had to ingest twice the volume of food to attain an equivalent intake of nutrients than no-choice flies on a diet of equivalent P:C ratio.

宏量营养素摄入会影响多种生物的生理、行为、生理学和基因表达。我们利用响应面方法比较了果蝇在有选择和无选择喂养方案下,蛋白质和碳水化合物摄入量对其生活史特征、寿命和繁殖的影响。我们发现,当交配雌蝇可选择营养互补的食物时,其蛋白质与碳水化合物的比例(P:C)与喂食一系列P:C不同的固定食物(无选择喂食方案)的雌蝇的反应面相比,蛋白质与碳水化合物的比例(P:C)与寿命缩短和最大产卵量有关。雄蝇和处女蝇的寿命在有选择喂养和无选择喂养之间没有差异,这反映了交配会增加蛋白质摄入量以支持产卵。然而,在交配雌蝇中,较高的 P:C 摄入量与选择和非选择喂养条件下更高的产卵量有关,但与预期相反,选择喂养的交配蝇比非选择喂养的蝇在同等宏量营养素摄入量下产卵量要少,这可能反映了它们必须摄入两倍的食物量才能达到同等的营养素摄入量,而非选择喂养的蝇在同等 P:C 比率的饮食条件下产卵量要比非选择喂养的蝇少。
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引用次数: 0
Loneliness, Living Alone, and Risk of Cardiovascular Disease Among Older Adults in China. 中国老年人的孤独感、独居与心血管疾病风险。
Siyue Tan, Dong Liu, Yuyi Zhang, Shengnan Li, Ke Zhang, Zaixiang Tang, Hui Zuo

Background: Older adults are prone to live alone and feel lonely. The main objective of this study was to assess the associations of loneliness and living alone with cardiovascular disease (CVD) among community-dwelling older individuals in China.

Methods: We conducted a longitudinal analysis on 3 661 participants aged older than 65 years from the latest 2014 and 2018 waves of the Chinese Longitudinal Healthy Longevity Survey. Cox proportional hazards models were used to assess the associations of loneliness and living alone with CVD risk, with adjustment for confounding factors.

Results: A total of 616 incident CVD cases were identified during follow-up. Participants who reported feeling lonely experienced a 28% increased risk of developing CVD after adjustment for sociodemographic characteristics, lifestyle factors, and baseline health status (adjusted hazard ratio [HR]: 1.28, 95% confidence interval [CI]: 1.01-1.62; ptrend = .046). In contrast, no significant association was observed between living alone and CVD risk. Subgroup analyses showed that among those individuals who lived alone, often feeling lonely doubled the risk of CVD compared to never being lonely (HR: 2.17, 95% CI: 1.20-3.93; ptrend = .007).

Conclusions: Loneliness was an independent risk factor for CVD among Chinese older adults. Our findings underscore the importance of addressing loneliness in the prevention of CVD among older individuals, especially those who live alone.

背景:老年人容易独居并感到孤独。本研究的主要目的是评估中国社区老年人的孤独感和独居与心血管疾病(CVD)的相关性:我们对中国健康长寿纵向调查(CLHLS)2014 年和 2018 年最新一期的 3661 名 65 岁以上参与者进行了纵向分析。采用Cox比例危险模型评估孤独和独居与心血管疾病风险的相关性,并对混杂因素进行调整:结果:随访期间共发现了 616 例心血管疾病病例。在对社会人口学特征、生活方式因素和基线健康状况进行调整后,报告感到孤独的参与者患心血管疾病的风险增加了28%(调整后危险比(HR):1.28,95%置信区间(CI):1.01-1.62;Ptrend = 0.046)。相比之下,在独居和心血管疾病风险之间没有观察到明显的关联。分组分析表明,在独居者中,经常感到孤独比从不感到孤独的人患心血管疾病的风险高一倍(HR:2.17,95% CI:1.20-3.93;Ptrend = 0.007):孤独是中国老年人心血管疾病的一个独立风险因素。我们的研究结果表明,解决孤独问题对于预防老年人心血管疾病,尤其是独居老年人的心血管疾病具有重要意义。
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引用次数: 0
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