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Vaccinations in children of non-European origin: The Vax4globe survey. 非欧洲血统儿童的疫苗接种:Vax4globe 调查。
Pub Date : 2024-12-02 Epub Date: 2024-10-31 DOI: 10.1016/j.vaccine.2024.126466
Viviana Moschese, Simona Graziani, Antonietta Spadea, Maurizia D'Amore, Raffaella Mosco, Sara Ciampini, Nicola Di Giorgio, Susanna Arcano, Simona Ceccarelli, Marco Chianca, Simona Piccinini, Antonella Polito, Marta Porcari, Pamela Puliafito, Romina Silenzi, Elisabetta Del Duca, Claudio Pignata, Michele Miraglia Del Giudice

Background: An equitable immunization coverage to "leave no one behind" is one of the World Health Organization Sustainable Development Goals. However, disparities in vaccination coverage exist. The present study aims to investigate vaccine attitude of non-European parents living in Italy and those factors affecting vaccine uptake and equity.

Methods: A cross sectional survey, named Vax4globe, on knowledge and immunization compliance in childhood and pregnancy of non-European (non-EU) parents was carried out among general pediatrician and Vaccine Centers located in Lazio Region, between February and July 2023. Logistic regression models were used in univariate and multivariate analyses to examine the socio-demographic parameters mainly associated with the vaccination status.

Results: A total of 310 parent/child pair were included in the study. Most children were born in Italy (262/310; 86.5 %), while while 40/310 (13.2 %) migrated from country of origin and 1/310 (0.3 %) was adopted. Mandatory vaccines were perfomed by 270/306 (88 %) children, however flu, papillomavirus and meningococcal group B were vaccines most commonly refused by 208/289 (72 %), 11/36 (31 %) and 9/36 (25 %) parents, respectively. A lower educational degree of parents (p = 0.040) and the migration status of children (p < 0.001) were associated to incomplete or missed immunization. As to maternal immunization 164/310 (53 %) non-EU women decided not to vaccinate and received less information (155/297;52 %) compared to childhood immunization (268/305; 88 %) (p < 0.0001). The educational degree (p = 0.017), the origin from non-EU European countries (p = 0.008) and the age 25-40 years (p = 0.036) and > 40 years (p = 0.007) were associated to lack of immunization during pregnancy. Finally, while 279/310 (90 %) parents were vaccinated against Sars-CoV-2, only 60/199 (30 %) children had been immunized with this vaccine mainly due to the non-mandatory vaccine request at pediatric age and to the doubts about its value according to 39/127 (31 %) and 29/127 (23 %) parents, respectively.

Conclusion: Our study highlights the need for targeted strategies to improve vaccine uptake both in childhood and in pregnancy among non-EU individuals living in Italy. Further, to achieve vaccination equity the role of institutions and healthcare personnel is pivotal to overcome vaccine hesitancy.

背景:实现公平的免疫接种覆盖率,"不让一个人掉队 "是世界卫生组织的可持续发展目标之一。然而,疫苗接种覆盖率存在差异。本研究旨在调查居住在意大利的非欧洲裔父母对疫苗的态度,以及影响疫苗接种率和公平性的因素:方法:2023 年 2 月至 7 月期间,在拉齐奥大区的普通儿科医生和疫苗中心开展了一项名为 "Vax4globe "的横断面调查,内容涉及非欧洲裔(非欧盟)父母在儿童期和孕期的疫苗接种知识和依从性。在单变量和多变量分析中使用了逻辑回归模型,以研究与疫苗接种情况主要相关的社会人口参数:共有 310 对父母/子女参与了研究。大多数儿童出生在意大利(262/310;86.5%),40/310(13.2%)来自原籍国,1/310(0.3%)是领养儿童。270/306(88%)名儿童接种了必须接种的疫苗,但208/289(72%)、11/36(31%)和9/36(25%)名家长最常拒绝接种的疫苗分别是流感疫苗、乳头瘤病毒疫苗和B群脑膜炎球菌疫苗。父母教育程度较低(p = 0.040)和儿童的移民身份(p 40 岁(p = 0.007))与孕期缺乏免疫接种有关。最后,虽然有 279/310 人(90%)的父母接种了 Sars-CoV-2,但只有 60/199 人(30%)的儿童接种了该疫苗,这主要是由于儿科年龄段的儿童没有强制要求接种疫苗,以及分别有 39/127 人(31%)和 29/127 人(23%)的父母对该疫苗的价值表示怀疑:我们的研究表明,有必要采取有针对性的策略,提高居住在意大利的非欧盟国家儿童和孕妇的疫苗接种率。此外,要实现疫苗接种的公平性,机构和医疗保健人员在克服疫苗接种犹豫方面的作用至关重要。
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引用次数: 0
RTS, S malaria vaccination among children aged 24-59 months in the Sunyani Municipality, Ghana; 2023. 加纳 Sunyani 市 24-59 个月儿童的 RTS、S 疟疾疫苗接种;2023 年。
Pub Date : 2024-12-02 Epub Date: 2024-10-31 DOI: 10.1016/j.vaccine.2024.126490
Mansulu Mohammed Zacharia, Sorengmen Amos Ziema, Williams Azumah Abanga, Richard Adinkrah Kyeremeh, Christopher Sunkwa Tamal, Michael Rockson Adjei, Chrysantus Kubio

Background: Following the successful pilot of RTS,S malaria vaccine, it has been recommended by the WHO for prevention of Plasmodium falciparum malaria in children living in endemic areas. Despite the proven benefits of the malaria vaccine, uptake especially of the fourth dose, remains relatively low. We assessed complete uptake of RTS,S malaria vaccine among children 24-59 months and associated factors in the Sunyani Municipality of Ghana.

Methods: A cross-sectional study was conducted among 361 caregivers of children aged 24-59 months in the Sunyani Municipality, who had received at least one dose of RTS,S malaria vaccine. Structured questionnaires were administered to caregivers and relevant vaccination information was extracted from the maternal and child health record books. Binary logistic regression analysis was used to determine factors associated with complete uptake of the vaccine at 95 % confidence interval (CI).

Results: Approximately 45 % (164/361) of the children had completed the RTS,S malaria vaccination schedule. Children aged 48-59 months (AOR:0.26, 95 %CI:0.09-0.76), those with caregivers who believed that children were being used for experiment (AOR:0.29, 95 %CI:0.16-0.54) or doubted the safety of the vaccine (AOR:0.27, 95 %CI:0.14-0.52) were less likely to complete the four doses. On the other hand, children of caregivers who reported vaccine shortages and travelled long distances to access immunization services (AOR:3.15, 95 %CI:1.17-8.47), and those with adequate knowledge on the malaria vaccine (AOR:1.89, 95 %CI:1.08-3.29) were more likely to complete the vaccination schedule.

Conclusion: Less than half of the children who started RTS,S malaria vaccination completed the full schedule. Age of child, caregiver knowledge and perception of the malaria vaccine, and access to immunization service were associated with complete uptake of the RTS,S malaria vaccine. Strengthening caregiver education and access to immunization services could improve uptake of the subsequent doses and coverage of the fourth dose.

背景:RTS,S疟疾疫苗试种成功后,世界卫生组织建议将其用于流行地区儿童恶性疟原虫疟疾的预防。尽管疟疾疫苗的益处已得到证实,但其接种率,尤其是第四剂的接种率仍然相对较低。我们评估了加纳苏亚尼市 24-59 个月儿童对 RTS,S 疟疾疫苗的完全接种率及相关因素:我们对桑亚尼市 361 名 24-59 个月儿童的看护者进行了横断面研究,这些儿童至少接种过一剂 RTS S 型疟疾疫苗。研究人员向照顾者发放了结构化问卷,并从母婴健康记录本中提取了相关的疫苗接种信息。采用二元逻辑回归分析来确定完全接种疫苗的相关因素,置信区间为 95%:结果:约 45% 的儿童(164/361)完成了 RTS S 疟疾疫苗接种计划。年龄在 48-59 个月的儿童(AOR:0.26,95 %CI:0.09-0.76)、照顾者认为儿童被用于实验的儿童(AOR:0.29,95 %CI:0.16-0.54)或怀疑疫苗安全性的儿童(AOR:0.27,95 %CI:0.14-0.52)完成四剂接种的可能性较低。另一方面,报告疫苗短缺和长途跋涉获得免疫服务(AOR:3.15, 95 %CI:1.17-8.47 )以及对疟疾疫苗有充分了解(AOR:1.89, 95 %CI:1.08-3.29 )的照顾者的子女更有可能完成疫苗接种计划:结论:开始接种RTS,S疟疾疫苗的儿童中只有不到一半的人完成了全部接种计划。儿童年龄、看护者对疟疾疫苗的了解和看法以及获得免疫服务的机会与完全接种 RTS S 疟疾疫苗有关。加强对照料者的教育和免疫接种服务可提高后续剂量的接种率和第四剂的覆盖率。
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引用次数: 0
Emerging global patterns of COVID-19 vaccine information fatigue in 23 countries in 2023. 2023 年 23 个国家 COVID-19 疫苗信息疲劳的全球新模式。
Pub Date : 2024-12-02 Epub Date: 2024-10-30 DOI: 10.1016/j.vaccine.2024.126475
Trenton M White, Jeffrey V Lazarus, Kenneth H Rabin, Scott C Ratzan, Ayman El-Mohandes

Vaccine information fatigue, exacerbated by the infodemic, misinformation, and cultural influences, hampers public responsiveness to the uptake of vaccines for COVID-19 and other vaccine-preventable diseases. This cross-sectional study of 23,000 respondents surveyed in 23 countries in October 2023 analyzed trust in information sources, perceptions of the pandemic's conclusion, and confidence in one's ability to discern false information from true and the association of these factors with willingness to pay attention to COVID-19 vaccine information, adjusting for sociodemographic characteristics. Results revealed that satisfaction with health authority communication was positively associated with individuals' willingness to pay attention to COVID-19 vaccine information in all 23 countries. Confidence in one's own capacity to distinguish true information from false was associated with willingness in 20 countries. Belief that the pandemic is over was associated with unwillingness to pay attention to COVID-19 vaccine information in 14 countries. These findings underscore the need for tailored communication strategies that build trust in information sources, combat complacency, and enhance discernment skills to address vaccine and pandemic fatigue, aiming to sustain public engagement with vaccine information and, ultimately, support vaccination efforts.

疫苗信息疲劳因信息疫情、错误信息和文化影响而加剧,阻碍了公众对 COVID-19 和其他疫苗可预防疾病疫苗的接种。这项横断面研究于 2023 年 10 月对 23 个国家的 23,000 名受访者进行了调查,分析了对信息来源的信任度、对流行病结论的看法、对个人辨别真假信息能力的信心,以及这些因素与关注 COVID-19 疫苗信息意愿的关联,并对社会人口特征进行了调整。结果显示,在所有 23 个国家中,对卫生当局沟通的满意度与个人关注 COVID-19 疫苗信息的意愿呈正相关。在 20 个国家中,个人对自身辨别信息真伪能力的信心与关注意愿相关。在 14 个国家,认为大流行已经结束与不愿意关注 COVID-19 疫苗信息有关。这些发现突出表明,有必要制定有针对性的传播策略,以建立对信息来源的信任、消除自满情绪并提高辨别能力,从而解决疫苗和大流行疲劳问题,目的是保持公众对疫苗信息的参与,并最终支持疫苗接种工作。
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引用次数: 0
Oral supplementation with postbiotics modulates the immune response produced by myxomatosis vaccination in wild rabbits. 口服补充益生菌可调节野兔接种霉形体病疫苗后产生的免疫反应。
Pub Date : 2024-08-13 Epub Date: 2024-05-17 DOI: 10.1016/j.vaccine.2024.05.026
E J García-Vicente, I Rey-Casero, M Martín, A Pérez, M Benito-Murcia, D Risco

Rabbits (Oryctolagus cuniculus) are vitally important species in the Iberian Peninsula ecosystem. However, since 1950, there has been a significant population decline, with major repercussions. This situation is mainly due to the presence of infectious diseases, such as myxomatosis, which is expanding and is characterized by severe and fatal clinical manifestations. Current control measures, mainly those based on vaccinations, are ineffective. Therefore, new strategies need to be developed and implemented. This study aimed to evaluate whether supplementation with postbiotic products modulates the immune response in wild rabbits vaccinated against myxomatosis. For this purpose, two groups of rabbits were established: a control group fed with standard feed ad libitum from weaning (28 days) until two months of age, and a treated group, which was fed under the same conditions but supplemented with postbiotics (3 kg/Tm). All the studied rabbits were vaccinated against this disease during weaning. In addition, a blood samples were obtained from all animals immediately before vaccination and 30 days later, which allowed us to evaluate the level of antibodies against myxomatosis virus (ELISA detection) and the relative expression of gene encoding to cytokines related to the immune response (IL6, TNFα and IFNγ), at both times of the experience. Weight and length measurements were also taken at both times to calculate body index and mean daily gain (MDG). No statistically significant differences in growth parameters were observed. There were also no differences in the serological response among groups. However, a relative underexpression of gene codifying to TNFα (p-value = 0.03683) and a higher expression on IFNγ (p-value = 0.045) were observed in the treated group. This modulation in cytokines could lead to less severe lesions in wild rabbit naturally infected with myxomatosis virus.

兔子(Oryctolagus cuniculus)是伊比利亚半岛生态系统中极其重要的物种。然而,自 1950 年以来,兔子数量大幅减少,造成了严重影响。造成这种情况的主要原因是存在传染病,例如蕈蚊病,这种疾病正在蔓延,其特点是临床表现严重且致命。目前的控制措施,主要是以疫苗接种为基础的措施,效果不佳。因此,需要制定和实施新的策略。本研究旨在评估补充益生后产品是否会调节接种过肌瘤病疫苗的野兔的免疫反应。为此,研究人员设立了两组兔子:一组为对照组,从断奶(28 天)起至两个月大期间自由采食标准饲料;另一组为治疗组,在相同条件下饲喂,但添加了益生菌(3 kg/Tm)。所有被研究的兔子都在断奶期间接种了预防该疾病的疫苗。此外,我们还在接种疫苗前和接种疫苗 30 天后采集了所有动物的血液样本,以评估这两个时间段兔子体内的肌瘤病毒抗体水平(ELISA 检测)和免疫反应相关细胞因子(IL6、TNFα 和 IFNγ)基因的相对表达量。还在两个时间段测量了体重和身长,以计算身体指数和平均日增重(MDG)。没有观察到生长参数有明显的统计学差异。各组之间的血清反应也没有差异。不过,在治疗组中观察到 TNFα 的编码基因表达相对较低(p 值 = 0.03683),而 IFNγ 的表达较高(p 值 = 0.045)。细胞因子的这种变化可能会使自然感染肌瘤病毒的野兔的病变程度减轻。
{"title":"Oral supplementation with postbiotics modulates the immune response produced by myxomatosis vaccination in wild rabbits.","authors":"E J García-Vicente, I Rey-Casero, M Martín, A Pérez, M Benito-Murcia, D Risco","doi":"10.1016/j.vaccine.2024.05.026","DOIUrl":"10.1016/j.vaccine.2024.05.026","url":null,"abstract":"<p><p>Rabbits (Oryctolagus cuniculus) are vitally important species in the Iberian Peninsula ecosystem. However, since 1950, there has been a significant population decline, with major repercussions. This situation is mainly due to the presence of infectious diseases, such as myxomatosis, which is expanding and is characterized by severe and fatal clinical manifestations. Current control measures, mainly those based on vaccinations, are ineffective. Therefore, new strategies need to be developed and implemented. This study aimed to evaluate whether supplementation with postbiotic products modulates the immune response in wild rabbits vaccinated against myxomatosis. For this purpose, two groups of rabbits were established: a control group fed with standard feed ad libitum from weaning (28 days) until two months of age, and a treated group, which was fed under the same conditions but supplemented with postbiotics (3 kg/Tm). All the studied rabbits were vaccinated against this disease during weaning. In addition, a blood samples were obtained from all animals immediately before vaccination and 30 days later, which allowed us to evaluate the level of antibodies against myxomatosis virus (ELISA detection) and the relative expression of gene encoding to cytokines related to the immune response (IL6, TNFα and IFNγ), at both times of the experience. Weight and length measurements were also taken at both times to calculate body index and mean daily gain (MDG). No statistically significant differences in growth parameters were observed. There were also no differences in the serological response among groups. However, a relative underexpression of gene codifying to TNFα (p-value = 0.03683) and a higher expression on IFNγ (p-value = 0.045) were observed in the treated group. This modulation in cytokines could lead to less severe lesions in wild rabbit naturally infected with myxomatosis virus.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"125978"},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric otitis media in Japan: A nationwide longitudinal study of the pre- and post-pneumococcal conjugate vaccine eras born in 2001 and 2010. 日本的小儿中耳炎:对 2001 年和 2010 年出生的肺炎球菌结合疫苗接种前后两个时期的全国性纵向研究。
Pub Date : 2024-07-25 Epub Date: 2024-05-17 DOI: 10.1016/j.vaccine.2024.05.020
Kensuke Uraguchi, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Seiichiro Makihara, Mizuo Ando, Takashi Yorifuji

Background: Otitis media (OM) is a prevalent respiratory disease in children and poses significant public health challenges due to its impact on child health and economic burdens. However, there have no nationwide epidemiological studies conducted in Japan. This study investigates the epidemiological trends of OM in Japan, taking into account the impact of the 7-valent pneumococcal conjugate vaccine (PCV7) introduction.

Method: This study was retrospective cohort study using secondary data on the nationwide longitudinal birth cohort. This survey followed two cohorts born in 2001 (pre-PCV era) and 2010 (post-PCV era) until the age of 9. Every year, parents were surveyed about their children's health status, including occurrences of OM. The annual period prevalence and cumulative incidence of OM were assessed in this study, and the two cohorts were compared using a modified Poisson regression model adjusted environmental factors with the 2001 cohort as reference.

Result: The study included 47,015 children from the 2001 cohort and 38,554 from the 2010 cohort. Peak annual period prevalence of OM varied by era. Cumulative incidence was 13.8 % for the 2001 cohort and 18.5 % for the 2010 cohort by 1.5 years of age and 28.9 % and 33.3 %, respectively, by 3.5 years of age. In particular, from the fourth survey onward, covering ages 2.5-3.5 years, a shift was observed from an increased risk to a decreased risk of OM.

Conclusion: This nationwide longitudinal study emphasizes variations in OM epidemiology across Japan over time, with changes potentially influenced by the introduction of PCV7. In this study, due to the absence of individual PCV7 vaccination data, the effect of PCV7 was estimated based on the vaccination rate at the population level. The results suggest a notable decrease in the incidence of OM in later years, aligning with the increased uptake of PCV7.

背景:中耳炎(OM)是儿童常见的呼吸道疾病,由于其对儿童健康和经济负担的影响,给公共卫生带来了巨大挑战。然而,日本尚未开展全国性的流行病学研究。本研究考虑到 7 价肺炎球菌结合疫苗(PCV7)引入的影响,对日本 OM 的流行趋势进行了调查:本研究是一项回顾性队列研究,使用的是全国纵向出生队列的二手数据。这项调查分别对 2001 年(接种 PCV 前)和 2010 年(接种 PCV 后)出生的两批儿童进行了跟踪调查,直至他们 9 岁。本研究评估了 OM 的年度流行率和累积发病率,并以 2001 年的队列为参照,使用调整了环境因素的改良泊松回归模型对两个队列进行了比较:研究包括 2001 年队列中的 47 015 名儿童和 2010 年队列中的 38 554 名儿童。OM的年高峰期发病率因年代而异。1.5 岁时,2001 年组群的累计发病率为 13.8%,2010 年组群为 18.5%,3.5 岁时分别为 28.9% 和 33.3%。特别是在 2.5-3.5 岁的第四次调查中,观察到 OM 风险从增加转为降低:这项全国范围的纵向研究强调了随着时间的推移,日本各地 OM 流行病学的变化,其中的变化可能受到 PCV7 引入的影响。在本研究中,由于缺乏个人 PCV7 疫苗接种数据,PCV7 的影响是根据人群接种率估算的。结果表明,随着 PCV7 接种率的提高,OM 的发病率在后来几年明显下降。
{"title":"Pediatric otitis media in Japan: A nationwide longitudinal study of the pre- and post-pneumococcal conjugate vaccine eras born in 2001 and 2010.","authors":"Kensuke Uraguchi, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Seiichiro Makihara, Mizuo Ando, Takashi Yorifuji","doi":"10.1016/j.vaccine.2024.05.020","DOIUrl":"10.1016/j.vaccine.2024.05.020","url":null,"abstract":"<p><strong>Background: </strong>Otitis media (OM) is a prevalent respiratory disease in children and poses significant public health challenges due to its impact on child health and economic burdens. However, there have no nationwide epidemiological studies conducted in Japan. This study investigates the epidemiological trends of OM in Japan, taking into account the impact of the 7-valent pneumococcal conjugate vaccine (PCV7) introduction.</p><p><strong>Method: </strong>This study was retrospective cohort study using secondary data on the nationwide longitudinal birth cohort. This survey followed two cohorts born in 2001 (pre-PCV era) and 2010 (post-PCV era) until the age of 9. Every year, parents were surveyed about their children's health status, including occurrences of OM. The annual period prevalence and cumulative incidence of OM were assessed in this study, and the two cohorts were compared using a modified Poisson regression model adjusted environmental factors with the 2001 cohort as reference.</p><p><strong>Result: </strong>The study included 47,015 children from the 2001 cohort and 38,554 from the 2010 cohort. Peak annual period prevalence of OM varied by era. Cumulative incidence was 13.8 % for the 2001 cohort and 18.5 % for the 2010 cohort by 1.5 years of age and 28.9 % and 33.3 %, respectively, by 3.5 years of age. In particular, from the fourth survey onward, covering ages 2.5-3.5 years, a shift was observed from an increased risk to a decreased risk of OM.</p><p><strong>Conclusion: </strong>This nationwide longitudinal study emphasizes variations in OM epidemiology across Japan over time, with changes potentially influenced by the introduction of PCV7. In this study, due to the absence of individual PCV7 vaccination data, the effect of PCV7 was estimated based on the vaccination rate at the population level. The results suggest a notable decrease in the incidence of OM in later years, aligning with the increased uptake of PCV7.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"4081-4087"},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccine value profile for schistosomiasis 血吸虫病疫苗价值概况
Pub Date : 2024-07-01 DOI: 10.1016/j.vaccine.2024.05.068
Gavin Yamey, Kaci Kennedy McDade, Roy M. Anderson, S. Bartsch, M. Bottazzi, D. Diemert, P. Hotez, Bruce Y. Lee, Donald McManus, Adebayo J. Molehin, M. Roestenberg, David Rollinson, Afzal A. Siddiqui, Miriam Tendler, Joanne P. Webster, Hong You, Raphaël M. Zellweger, Caroline Marshall
{"title":"Vaccine value profile for schistosomiasis","authors":"Gavin Yamey, Kaci Kennedy McDade, Roy M. Anderson, S. Bartsch, M. Bottazzi, D. Diemert, P. Hotez, Bruce Y. Lee, Donald McManus, Adebayo J. Molehin, M. Roestenberg, David Rollinson, Afzal A. Siddiqui, Miriam Tendler, Joanne P. Webster, Hong You, Raphaël M. Zellweger, Caroline Marshall","doi":"10.1016/j.vaccine.2024.05.068","DOIUrl":"https://doi.org/10.1016/j.vaccine.2024.05.068","url":null,"abstract":"","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"19 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141845885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brucella melitensis Rev1Δwzm: Placental pathogenesis studies and safety in pregnant ewes. 布鲁氏菌 Rev1Δwzm:妊娠母羊的胎盘致病机理研究和安全性。
Pub Date : 2024-05-15 DOI: 10.1016/j.vaccine.2024.04.085
Irati Poveda-Urkixo, Sara Mena-Bueno, Gustavo A Ramírez, Ana Zabalza-Baranguá, Renee M Tsolis, María-Jesús Grilló

One of the main causes of human brucellosis is Brucella melitensis infecting small ruminants. To date, Rev1 is the only vaccine successfully used to control ovine and caprine brucellosis. However, it is pathogenic for pregnant animals, resulting in abortions and vaginal and milk shedding, as well as being infectious for humans. Therefore, there is an urgent need to develop an effective vaccine that is safer than Rev1. In efforts to further attenuate Rev1, we recently used wzm inactivation to generate a rough mutant (Rev1Δwzm) that retains a complete antigenic O-polysaccharide in the bacterial cytoplasm. The aim of the present study was to evaluate the placental pathogenicity of Rev1Δwzm in trophoblastic cells, throughout pregnancy in mice, and in ewes inoculated in different trimesters of pregnancy. This mutant was evaluated in comparison with the homologous 16MΔwzm derived from a virulent strain of B. melitensis and the naturally rough sheep pathogen B. ovis. Our results show that both wzm mutants triggered reduced cytotoxic, pro-apoptotic, and pro-inflammatory signaling in Bewo trophoblasts, as well as reduced relative expression of apoptosis genes. In mice, both wzm mutants produced infection but were rapidly cleared from the placenta, in which only Rev1Δwzm induced a low relative expression of pro-apoptotic and pro-inflammatory genes. In the 66 inoculated ewes, Rev1Δwzm was safe and immunogenic, displaying a transient serological interference in standard RBT but not CFT S-LPS tests; this serological response was minimized by conjunctival administration. In conclusion, these results support that B. melitensis Rev1Δwzm is a promising vaccine candidate for use in pregnant ewes and its efficacy against B. melitensis and B. ovis infections in sheep warrants further study.

人类布鲁氏菌病的主要病因之一是小反刍动物感染了布鲁氏菌。迄今为止,Rev1 是唯一成功用于控制绵羊和山羊布鲁氏菌病的疫苗。然而,它对怀孕动物具有致病性,会导致流产、阴道和乳汁脱落,对人类也有传染性。因此,迫切需要开发一种比 Rev1 更安全的有效疫苗。为了进一步减弱Rev1,我们最近利用wzm灭活技术产生了一种粗糙突变体(Rev1Δwzm),它在细菌胞质中保留了完整的抗原O-多糖。本研究旨在评估Rev1Δwzm在滋养细胞、小鼠整个妊娠期以及母羊不同妊娠期接种的胎盘致病性。我们将该突变体与来自梅毒杆菌毒株的同源16MΔwzm和天然粗糙的绵羊病原体B. ovis进行了比较评估。我们的研究结果表明,这两种 wzm 突变体在 Bewo 滋养细胞中引发的细胞毒性、促凋亡和促炎症信号转导减少,凋亡基因的相对表达也减少。在小鼠体内,两种 wzm 突变体都会产生感染,但会迅速从胎盘中清除,其中只有 Rev1Δwzm 能诱导较低的促凋亡和促炎症基因的相对表达。在接种的 66 只母羊中,Rev1Δwzm 是安全的,具有免疫原性,在标准 RBT 而非 CFT S-LPS 试验中显示出短暂的血清学干扰;结膜给药可将这种血清学反应降至最低。总之,这些结果表明梅毒杆菌 Rev1Δwzm 是一种很有前途的候选疫苗,可用于妊娠母羊,其对绵羊梅毒杆菌和绵羊猫鼬感染的有效性值得进一步研究。
{"title":"Brucella melitensis Rev1Δwzm: Placental pathogenesis studies and safety in pregnant ewes.","authors":"Irati Poveda-Urkixo, Sara Mena-Bueno, Gustavo A Ramírez, Ana Zabalza-Baranguá, Renee M Tsolis, María-Jesús Grilló","doi":"10.1016/j.vaccine.2024.04.085","DOIUrl":"https://doi.org/10.1016/j.vaccine.2024.04.085","url":null,"abstract":"<p><p>One of the main causes of human brucellosis is Brucella melitensis infecting small ruminants. To date, Rev1 is the only vaccine successfully used to control ovine and caprine brucellosis. However, it is pathogenic for pregnant animals, resulting in abortions and vaginal and milk shedding, as well as being infectious for humans. Therefore, there is an urgent need to develop an effective vaccine that is safer than Rev1. In efforts to further attenuate Rev1, we recently used wzm inactivation to generate a rough mutant (Rev1Δwzm) that retains a complete antigenic O-polysaccharide in the bacterial cytoplasm. The aim of the present study was to evaluate the placental pathogenicity of Rev1Δwzm in trophoblastic cells, throughout pregnancy in mice, and in ewes inoculated in different trimesters of pregnancy. This mutant was evaluated in comparison with the homologous 16MΔwzm derived from a virulent strain of B. melitensis and the naturally rough sheep pathogen B. ovis. Our results show that both wzm mutants triggered reduced cytotoxic, pro-apoptotic, and pro-inflammatory signaling in Bewo trophoblasts, as well as reduced relative expression of apoptosis genes. In mice, both wzm mutants produced infection but were rapidly cleared from the placenta, in which only Rev1Δwzm induced a low relative expression of pro-apoptotic and pro-inflammatory genes. In the 66 inoculated ewes, Rev1Δwzm was safe and immunogenic, displaying a transient serological interference in standard RBT but not CFT S-LPS tests; this serological response was minimized by conjunctival administration. In conclusion, these results support that B. melitensis Rev1Δwzm is a promising vaccine candidate for use in pregnant ewes and its efficacy against B. melitensis and B. ovis infections in sheep warrants further study.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interchangeability of different COVID-19 vaccine platforms as booster doses: A phase 3 study mimicking real-world practice 不同 COVID-19 疫苗平台作为加强剂量的互换性:模拟真实世界实践的 3 期研究
Pub Date : 2024-05-01 DOI: 10.1016/j.vaccine.2024.05.009
Sue Ann Costa Clemens, Lily Weckx, Eveline P. Milan, Igor Smolenov, Ralf Clemens
{"title":"Interchangeability of different COVID-19 vaccine platforms as booster doses: A phase 3 study mimicking real-world practice","authors":"Sue Ann Costa Clemens, Lily Weckx, Eveline P. Milan, Igor Smolenov, Ralf Clemens","doi":"10.1016/j.vaccine.2024.05.009","DOIUrl":"https://doi.org/10.1016/j.vaccine.2024.05.009","url":null,"abstract":"","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141029375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of mRNA booster doses in preventing infections and hospitalizations due to SARS-CoV-2 and its dominant variant over time in Valencian healthcare workers, Spain. mRNA 强化剂量在预防西班牙巴伦西亚医护人员感染 SARS-CoV-2 及其显性变种并随时间推移住院治疗方面的效果。
Pub Date : 2024-05-01 DOI: 10.1016/j.vaccine.2024.05.011
Natali Jiménez-Sepúlveda, Paula Gras-Valenti, P. Chico-Sánchez, José Miguel Castro-García, Elena Ronda-Pérez, H. Vanaclocha, S. Peiró, J. S. Burgos, Ana Berenguer, D. Navarro, José Sánchez-Payá
{"title":"Effectiveness of mRNA booster doses in preventing infections and hospitalizations due to SARS-CoV-2 and its dominant variant over time in Valencian healthcare workers, Spain.","authors":"Natali Jiménez-Sepúlveda, Paula Gras-Valenti, P. Chico-Sánchez, José Miguel Castro-García, Elena Ronda-Pérez, H. Vanaclocha, S. Peiró, J. S. Burgos, Ana Berenguer, D. Navarro, José Sánchez-Payá","doi":"10.1016/j.vaccine.2024.05.011","DOIUrl":"https://doi.org/10.1016/j.vaccine.2024.05.011","url":null,"abstract":"","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"42 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141043647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative analysis of cholera serum vibriocidal antibodies from Convalescent and vaccinated adults in Zambia. 赞比亚霍乱痊愈者和接种过疫苗的成年人血清中杀弧菌抗体的比较分析。
Pub Date : 2024-05-01 DOI: 10.1016/j.vaccine.2024.05.027
Harriet Ng’ombe, S. Bosomprah, Bernard Phiri, Mutinta Muchimba, Fraser Liswaniso, Mwelwa Chibuye, C. C. Luchen, Kennedy Chibesa, Kalo Musukuma-Chifulo, K. Mwape, Sekayi Tigere, Suwilanji Silwamba, Annel Sinkala, M. Simuyandi, Nyuma Mbewe, Fred Kapaya, Adam F Cunningham, R. Chilengi, David Sack, C. Chisenga
{"title":"Comparative analysis of cholera serum vibriocidal antibodies from Convalescent and vaccinated adults in Zambia.","authors":"Harriet Ng’ombe, S. Bosomprah, Bernard Phiri, Mutinta Muchimba, Fraser Liswaniso, Mwelwa Chibuye, C. C. Luchen, Kennedy Chibesa, Kalo Musukuma-Chifulo, K. Mwape, Sekayi Tigere, Suwilanji Silwamba, Annel Sinkala, M. Simuyandi, Nyuma Mbewe, Fred Kapaya, Adam F Cunningham, R. Chilengi, David Sack, C. Chisenga","doi":"10.1016/j.vaccine.2024.05.027","DOIUrl":"https://doi.org/10.1016/j.vaccine.2024.05.027","url":null,"abstract":"","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"101 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141052336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Vaccine
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