Crude oil; is a fossil energy source that has become possible to be used by refining processes and has a critical importance for the welfare, economic development, and quality of life of the society. As a result of the use of fossil fuels, carbon dioxide (CO2), sulfur oxide (SOx), and other greenhouse gases are released and these gases are expressed as the main cause of global climate change. For this reason, scientists are making an intense effort to minimize the harmful effects of SOx gases released as a result of combustion reactions in crude oil. In this presented study; the sulfur content of crude oil has been tried to be reduced by an adsorptive desulfurization technique by using expanded perlite, which is a volcanic rock type and expands as a result of heating and takes on a porous structure. For this purpose, 50 mL samples of crude oil were treated separately with 2, 4, 6, 8, and 10 g of expanded perlite and then exposed to an adsorptive desulfurization process by mixing with a magnetic stirrer at 400 rpm for an hour at room temperature. Then, it was separated from the adsorbent with the help of a centrifuge and the amount of sulfur was determined by the LECO 628S device according to ASTM D 1552-03 method. As a result of the study, it was determined that the amount of sulfur in crude oil decreased by 10.82 %. The study's findings showed that the expanded crude perlite had a good capacity for sulfide loading, was renewably good, and had a stable structure for removing sulfur compounds.
原油;是一种化石能源，可以通过精炼过程加以利用，对社会福利、经济发展和生活质量具有至关重要的意义。由于化石燃料的使用，二氧化碳(CO2)、硫氧化物(SOx)和其他温室气体被释放出来，这些气体被认为是全球气候变化的主要原因。因此，科学家们正在努力将原油燃烧反应释放的硫氧化物气体的有害影响降到最低。在本研究中;利用膨胀珍珠岩的吸附脱硫技术，试图降低原油中的硫含量。膨胀珍珠岩是一种火山岩类型，由于加热而膨胀，呈多孔结构。为此，分别用2、4、6、8和10 g膨胀珍珠岩处理50 mL原油样品，然后在室温下用磁力搅拌器以400转/分的速度搅拌1小时，进行吸附脱硫过程。然后，利用离心机将其从吸附剂中分离出来，用LECO 628S装置按照ASTM D 1552-03方法测定硫的量。研究结果表明，原油中硫含量降低了10.82%。研究结果表明，膨胀后的原油珍珠岩具有良好的载硫能力，可再生性好，具有稳定的脱硫结构。
{"title":"Adsorptive Desulfurization of Crude Oil with Expanded Perlite","authors":"A. Özkan, V. Özkan","doi":"10.48138/cjo.1206761","DOIUrl":"https://doi.org/10.48138/cjo.1206761","url":null,"abstract":"Crude oil; is a fossil energy source that has become possible to be used by refining processes and has a critical importance for the welfare, economic development, and quality of life of the society. As a result of the use of fossil fuels, carbon dioxide (CO2), sulfur oxide (SOx), and other greenhouse gases are released and these gases are expressed as the main cause of global climate change. For this reason, scientists are making an intense effort to minimize the harmful effects of SOx gases released as a result of combustion reactions in crude oil. \u0000In this presented study; the sulfur content of crude oil has been tried to be reduced by an adsorptive desulfurization technique by using expanded perlite, which is a volcanic rock type and expands as a result of heating and takes on a porous structure. For this purpose, 50 mL samples of crude oil were treated separately with 2, 4, 6, 8, and 10 g of expanded perlite and then exposed to an adsorptive desulfurization process by mixing with a magnetic stirrer at 400 rpm for an hour at room temperature. Then, it was separated from the adsorbent with the help of a centrifuge and the amount of sulfur was determined by the LECO 628S device according to ASTM D 1552-03 method. \u0000As a result of the study, it was determined that the amount of sulfur in crude oil decreased by 10.82 %. The study's findings showed that the expanded crude perlite had a good capacity for sulfide loading, was renewably good, and had a stable structure for removing sulfur compounds.","PeriodicalId":9662,"journal":{"name":"Caucasian Journal of Science","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83205598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This research is conducted to determine the relation between symptoms of premenstrual term of nurses who work in Kars and predisposition to somatization. This is a cross-sectional research. The population of this research are consisted of 108 nurses who work in Kars Kafkas University Training and Research Hospital in the process of the study. Any sample from population is not selected however 87 nurses who are proper for study criterias and present at the time of research participated voluntarily. During data collection Survey, premenstrual syndrome scale and somatization scale are used by researcher. Descriptive statistics (average, standard deviation, minimum, maximum), frequencies for categorical variables (score, percentage), t test, Mann Whitney U, Pearson Corelation, Kruskal-Wallis test are used while data evaluation. The level of Premenstrual Syndrom of the participants 124,80±42,969. Somatization level is 14,49±5,471. It is found 49% positive way relation between Somatization and Premenstrual Syndrom as a result of corelation analysis applied. As a result of research it is determined that there is a signicifant relation between Premenstrual Syndrom and Somatization. It is detected that women who has Premenstrual Syndrom are negatively affected in daily and working life.
{"title":"The Relation Between Symptoms of Premenstrual Term of Nurses Who Work in Kars and Predisposition to Somatization","authors":"Ayşe Gül Geli̇r, S. Eliş Yıldız","doi":"10.48138/cjo.1072432","DOIUrl":"https://doi.org/10.48138/cjo.1072432","url":null,"abstract":"This research is conducted to determine the relation between symptoms of premenstrual term of nurses who work in Kars and predisposition to somatization. This is a cross-sectional research. The population of this research are consisted of 108 nurses who work in Kars Kafkas University Training and Research Hospital in the process of the study. Any sample from population is not selected however 87 nurses who are proper for study criterias and present at the time of research participated voluntarily. During data collection Survey, premenstrual syndrome scale and somatization scale are used by researcher. Descriptive statistics (average, standard deviation, minimum, maximum), frequencies for categorical variables (score, percentage), t test, Mann Whitney U, Pearson Corelation, Kruskal-Wallis test are used while data evaluation. The level of Premenstrual Syndrom of the participants 124,80±42,969. Somatization level is 14,49±5,471. It is found 49% positive way relation between Somatization and Premenstrual Syndrom as a result of corelation analysis applied. As a result of research it is determined that there is a signicifant relation between Premenstrual Syndrom and Somatization. It is detected that women who has Premenstrual Syndrom are negatively affected in daily and working life.","PeriodicalId":9662,"journal":{"name":"Caucasian Journal of Science","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80489706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CrystalExplorer program is a program that has been used frequently in the field of theoretical chemistry in recent years and its popularity has increased. First of all, Hirshfeld surface analysis of molecules can be done in this program. Thanks to Hirshfeld surface analysis, intermolecular interactions and their contributions to the crystal surface can be determined. In this study, Hirshfeld surface analyzes and energy frameworks of nicotinamide complexes of Co(II), Cu(II), Ni(II) and Zn(II) 4-formylbenzoate were investigated. Dnorm index, shape index, curvature index and 2D fingerprint graphs were examined for all complexes. In addition, the intermolecular interaction energies of the complexes were calculated using the CE-B3LYP/6-31G (d,p) and CEHF/3-21G energy models. As a result of all these, it was seen that the most important interaction in the four isostructured complexes was H...H interactions. According to Hirshfeld surface analysis and energy frameworks, O-H...O and N-H...O hydrogen bonds and π•••π stacking and C−H••π interaction energies are seen as the most important interaction types in the crystal structure.
{"title":"Determination of Intermolecular Interactions of Nicotinamide Liganded Complexes of Co(II), Cu(II), Ni(II) and Zn(II) 4-Formilbenzoates by Hirshfeld Surface Analysis and Investigation of Interaction Energies.","authors":"Mustafa Sertçelik","doi":"10.48138/cjo.1205712","DOIUrl":"https://doi.org/10.48138/cjo.1205712","url":null,"abstract":"CrystalExplorer program is a program that has been used frequently in the field of theoretical chemistry in recent years and its popularity has increased. First of all, Hirshfeld surface analysis of molecules can be done in this program. Thanks to Hirshfeld surface analysis, intermolecular interactions and their contributions to the crystal surface can be determined. In this study, Hirshfeld surface analyzes and energy frameworks of nicotinamide complexes of Co(II), Cu(II), Ni(II) and Zn(II) 4-formylbenzoate were investigated. Dnorm index, shape index, curvature index and 2D fingerprint graphs were examined for all complexes. In addition, the intermolecular interaction energies of the complexes were calculated using the CE-B3LYP/6-31G (d,p) and CEHF/3-21G energy models. As a result of all these, it was seen that the most important interaction in the four isostructured complexes was H...H interactions. \u0000According to Hirshfeld surface analysis and energy frameworks, O-H...O and N-H...O hydrogen bonds and π•••π stacking and C−H••π interaction energies are seen as the most important interaction types in the crystal structure.","PeriodicalId":9662,"journal":{"name":"Caucasian Journal of Science","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77412935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, the effects of solvents and molecular structure upon acidity, five 3-alkyl(aryl)-4-phthalimido-4,5-dihydro-1H-1,2,4-triazol-5-ones (3-7) were potentiometrically titrated with tetrabutylammonium hydroxide (TBAH) in four different anhydrous solvents (isopropyl alcohol, acetonitrile, tert-butyl alcohol and N,N-dimethylformamide) and HNP and corresponding pKa values were determined by half-neutralization method for all cases.
{"title":"Determination of HNP and pKa Values of Some 3-Alkyl(Aryl)-4-phthalimido-4,5-dihydro-1H-1,2,4-triazol-5-one Compounds by Semi-Neutralization Method","authors":"H. Yüksek, S. Manap, G. Özdemir","doi":"10.48138/cjo.1200631","DOIUrl":"https://doi.org/10.48138/cjo.1200631","url":null,"abstract":"In this study, the effects of solvents and molecular structure upon acidity, five 3-alkyl(aryl)-4-phthalimido-4,5-dihydro-1H-1,2,4-triazol-5-ones (3-7) were potentiometrically titrated with tetrabutylammonium hydroxide (TBAH) in four different anhydrous solvents (isopropyl alcohol, acetonitrile, tert-butyl alcohol and N,N-dimethylformamide) and HNP and corresponding pKa values were determined by half-neutralization method for all cases.","PeriodicalId":9662,"journal":{"name":"Caucasian Journal of Science","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79460206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bu araştırma, ebelik öğrencilerinin adli vakalara yaklaşımı ile adli ebelik hakkındaki bilgi ve görüşlerinin belirlenmesi amacıyla yapılmıştır. Bu araştırma Atatürk Üniversitenin Sağlık Bilimleri Fakültesi ebelik bölümü 3. ve 4. sınıf öğrencileri ile tanımlayıcı-karşılaştırmalı olarak yapılmıştır. Araştırmada örnekleme yöntemine gidilmemiş, evrenin tamamına ulaşılmaya çalışılarak toplam 173 öğrenci ile yürütülmüştür. Araştırmada öğrencilere 18 yaş altı genital muayene yapma teklifi ile karşılaştığında 3. Sınıf öğrencilerin %31.2’si yapmayacağını, %18.2’si bu durum karşısında ne yapacağını bilmediğini, %4.3 yapacağını, %10.8’i de kişinin onayının olup olmadığını soracağını belirtmiştir. 4.sınıf öğrencilerin bu durum karşısındaki tutumunu incelediğimizde ise öğrencilerin %21.3’ünün yapmayacağını, %16.3’ü bilmediğini belirtmiştir. Ebelik 3. sınıf öğrencilerinin adli ebelik alanında çalışmak isteme durumu sorulduğunda %58.1’i bu alanda çalışmak istediğini belirtmiştir. Çalışmak isteme nedeni olarak öğrencilerin %54.5’i bu alanın ilgisini çektiğini belirtmiş. 4. Sınıf öğrencilere baktığımızda ise öğrencilerin %45 bu alanda çalışmak istediğini ve çalışmak isteyen öğrenciler arasında %47.4’ü de bu alanın ilgisini çektiğini belirtmiştir. Ebelik öğrencilerin adli vaka ve bu vakalar ile karşılaştıklarında nasıl davranacaklarını bilmedikleri belirlenmiştir.
{"title":"Ebelik Öğrencilerinin Adli Vaka ve Adli Ebelik Konusunda Bilgi ve Görüşlerinin Değerlendirilmesi: Tanımlayıcı Çalışma","authors":"Sibel Öztürk, Safiye AĞAPINAR ŞAHİN","doi":"10.48138/cjo.1084609","DOIUrl":"https://doi.org/10.48138/cjo.1084609","url":null,"abstract":"Bu araştırma, ebelik öğrencilerinin adli vakalara yaklaşımı ile adli ebelik hakkındaki bilgi ve görüşlerinin belirlenmesi amacıyla yapılmıştır. Bu araştırma Atatürk Üniversitenin Sağlık Bilimleri Fakültesi ebelik bölümü 3. ve 4. sınıf öğrencileri ile tanımlayıcı-karşılaştırmalı olarak yapılmıştır. Araştırmada örnekleme yöntemine gidilmemiş, evrenin tamamına ulaşılmaya çalışılarak toplam 173 öğrenci ile yürütülmüştür. Araştırmada öğrencilere 18 yaş altı genital muayene yapma teklifi ile karşılaştığında 3. Sınıf öğrencilerin %31.2’si yapmayacağını, %18.2’si bu durum karşısında ne yapacağını bilmediğini, %4.3 yapacağını, %10.8’i de kişinin onayının olup olmadığını soracağını belirtmiştir. 4.sınıf öğrencilerin bu durum karşısındaki tutumunu incelediğimizde ise öğrencilerin %21.3’ünün yapmayacağını, %16.3’ü bilmediğini belirtmiştir. Ebelik 3. sınıf öğrencilerinin adli ebelik alanında çalışmak isteme durumu sorulduğunda %58.1’i bu alanda çalışmak istediğini belirtmiştir. Çalışmak isteme nedeni olarak öğrencilerin %54.5’i bu alanın ilgisini çektiğini belirtmiş. 4. Sınıf öğrencilere baktığımızda ise öğrencilerin %45 bu alanda çalışmak istediğini ve çalışmak isteyen öğrenciler arasında %47.4’ü de bu alanın ilgisini çektiğini belirtmiştir. Ebelik öğrencilerin adli vaka ve bu vakalar ile karşılaştıklarında nasıl davranacaklarını bilmedikleri belirlenmiştir.","PeriodicalId":9662,"journal":{"name":"Caucasian Journal of Science","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74020419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Escherichia coli O157: H7 strain was used as the standard strain for bacteriophages isolated from polluted environmental foci and animal waste-contaminated waters, and some of the enteroinvasive Escherichia coli strains previously isolated from sporadic cases were used to determine the host diversity of phages. The physiological properties of bacteriophages specific to Escherichia coli O157:H7, designated Escherichiaphage NL1, were studied. After the isolation step, bacteriophages were purified and their titer was increased. Cross-antigenic properties of the hosts were investigated with Escherichia phage NL1 phage. One-step growth curve parameters such as adsorption time of phages, latent period, burst size, multiplicity of infection value (MOI) were determined. Results showed that bacteriophage NL1 completely lysed the E.coli O157:H7 (RSKK 09007) and E.coli O:164 RSKK 324. In the study, the effects of phage NL1 only on E.coli O157:H7 were investigated. The calculated highest titer was determined as Optimal multiplycity of infection (2.16x108). It was determined that the latent period lasted for 20 minutes and the phage was reached the burst size at approximately 90 minutes.
{"title":"Biological properties of a newly isolated bacteriophage (NL1) that infects Escherichia coli O157:H7 strain","authors":"N. Mutlu, E. Koç, Ö. Özden","doi":"10.48138/cjo.1112953","DOIUrl":"https://doi.org/10.48138/cjo.1112953","url":null,"abstract":"Escherichia coli O157: H7 strain was used as the standard strain for bacteriophages isolated from polluted environmental foci and animal waste-contaminated waters, and some of the enteroinvasive Escherichia coli strains previously isolated from sporadic cases were used to determine the host diversity of phages. The physiological properties of bacteriophages specific to Escherichia coli O157:H7, designated Escherichiaphage NL1, were studied. After the isolation step, bacteriophages were purified and their titer was increased. Cross-antigenic properties of the hosts were investigated with Escherichia phage NL1 phage. One-step growth curve parameters such as adsorption time of phages, latent period, burst size, multiplicity of infection value (MOI) were determined. Results showed that bacteriophage NL1 completely lysed the E.coli O157:H7 (RSKK 09007) and E.coli O:164 RSKK 324. In the study, the effects of phage NL1 only on E.coli O157:H7 were investigated. The calculated highest titer was determined as Optimal multiplycity of infection (2.16x108). It was determined that the latent period lasted for 20 minutes and the phage was reached the burst size at approximately 90 minutes.","PeriodicalId":9662,"journal":{"name":"Caucasian Journal of Science","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76610848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. T. Şensoy, I. H. Korkmaz, Fatih Medetalibeyoglu, I. Kaymaz
When the graft donor areas are evaluated in terms of bone reserve and functional aspects, it can be said that the iliac site has outstanding properties. However, complications of graft harvesting operations performed from various iliac donor sites have been reported by many researchers. Numerous studies have been carried out in the literature to reduce these complications, and to increase the success of the operation. However, biomechanical comparison of anterior and posterior iliac graft harvesting operations is one of the gaps in the literature. This study aims to assess both biomechanical behavior and bone graft reserve comparison of the two surgical operation alternatives. According to the FEA results of the study, posterior iliac graft harvesting provides 264% more trabecular bone reserve than anterior operation. However, this rate is 132% for cortical bone. When the models are compared, anterior osteotomy model has a 8.6% higher von Mises strain compared to the posterior osteotomy model. Results of the present study has shown that the region with the highest stress value in the cortical bone is the sacroiliac joint for both models. While posterior graft harvesting operation offers advantages in terms of morbidity rate, joint fracture risk and graft reserve, anterior operation can be preferred in terms of operational ease and the sacroiliac joint stability. However, since results obtained may be affected by the factors such as the amount of graft harvested, the patient's bone quality, anatomical differences, age and gender, it has been evaluated that the success of the operation may be enhanced by carrying out a patient-specific approach for modeling and analysis steps.
{"title":"Evaluation of Graft Harvesting Operations from Anterior and Posterior Iliac Donor Sites by Finite Element Analysis","authors":"A. T. Şensoy, I. H. Korkmaz, Fatih Medetalibeyoglu, I. Kaymaz","doi":"10.48138/cjo.1003613","DOIUrl":"https://doi.org/10.48138/cjo.1003613","url":null,"abstract":"When the graft donor areas are evaluated in terms of bone reserve and functional aspects, it can be said that the iliac site has outstanding properties. However, complications of graft harvesting operations performed from various iliac donor sites have been reported by many researchers. Numerous studies have been carried out in the literature to reduce these complications, and to increase the success of the operation. However, biomechanical comparison of anterior and posterior iliac graft harvesting operations is one of the gaps in the literature. This study aims to assess both biomechanical behavior and bone graft reserve comparison of the two surgical operation alternatives. According to the FEA results of the study, posterior iliac graft harvesting provides 264% more trabecular bone reserve than anterior operation. However, this rate is 132% for cortical bone. When the models are compared, anterior osteotomy model has a 8.6% higher von Mises strain compared to the posterior osteotomy model. Results of the present study has shown that the region with the highest stress value in the cortical bone is the sacroiliac joint for both models. While posterior graft harvesting operation offers advantages in terms of morbidity rate, joint fracture risk and graft reserve, anterior operation can be preferred in terms of operational ease and the sacroiliac joint stability. However, since results obtained may be affected by the factors such as the amount of graft harvested, the patient's bone quality, anatomical differences, age and gender, it has been evaluated that the success of the operation may be enhanced by carrying out a patient-specific approach for modeling and analysis steps.","PeriodicalId":9662,"journal":{"name":"Caucasian Journal of Science","volume":"1105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76750770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recent studies have revealed that boron compounds can be effective in the treatment of obesity, which is known to be one of the most dangerous and complex health problems of this age. In this study, the therapeutic effect of boron molecules in the diet on obesity was investigated. For this purpose, the effects of boron compounds on Total Antioxidant Status (TAS), Total Oxidant Status (TOS), High Density Lipoprotein (HDL) levels and paraoxanase (PON) activity were investigated in mice fed a high-fat diet. The study material was 40 Sprague Dawley rats 4-5 months old with a mean live weight of 226.95 ± 5.75 g. Animals were divided into 4 groups as Group I (normal diet), Group II (High fat), Group III (High fat + Boric Acid) and Group IV (Boric Acid). Six weeks after the experiment, blood samples were taken from the animals and TAS, TOS, HDL levels and PON activity were measured from the samples. In addition, the live weight changes of the animals were recorded. At the end of the study, we found that boric acid given in addition to drinking water did not significantly change TAS level and PON activity, but increased TOS and HDL levels. In addition, the weight average of the group treated with boric acid decreased. As a result, boric acid did not have an effect on the antioxidant system, but it caused an increase in HDL level and a decrease in PON activity. In addition, boric acid can be effective in lowering body weight.
{"title":"Investigation the Effect of Boric Acid effect on Antioxidant System, HDL Levels and PON Activity on Rats Feding to the High-Fat Diet","authors":"Destan Kalacay, O. Atakisi","doi":"10.48138/cjo.994111","DOIUrl":"https://doi.org/10.48138/cjo.994111","url":null,"abstract":"Recent studies have revealed that boron compounds can be effective in the treatment of obesity, which is known to be one of the most dangerous and complex health problems of this age. In this study, the therapeutic effect of boron molecules in the diet on obesity was investigated. \u0000For this purpose, the effects of boron compounds on Total Antioxidant Status (TAS), Total Oxidant Status (TOS), High Density Lipoprotein (HDL) levels and paraoxanase (PON) activity were investigated in mice fed a high-fat diet. \u0000The study material was 40 Sprague Dawley rats 4-5 months old with a mean live weight of 226.95 ± 5.75 g. Animals were divided into 4 groups as Group I (normal diet), Group II (High fat), Group III (High fat + Boric Acid) and Group IV (Boric Acid). Six weeks after the experiment, blood samples were taken from the animals and TAS, TOS, HDL levels and PON activity were measured from the samples. In addition, the live weight changes of the animals were recorded. \u0000At the end of the study, we found that boric acid given in addition to drinking water did not significantly change TAS level and PON activity, but increased TOS and HDL levels. In addition, the weight average of the group treated with boric acid decreased. \u0000As a result, boric acid did not have an effect on the antioxidant system, but it caused an increase in HDL level and a decrease in PON activity. In addition, boric acid can be effective in lowering body weight.","PeriodicalId":9662,"journal":{"name":"Caucasian Journal of Science","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88673400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kanser tedavisinde son yıllarda başarı oranını artıran ilaç ve yöntemler geliştirilmiştir. Ancak toksisitesi düşük ve yüksek derecede etkili bir ilaç üretilememiştir. Bu araştırma akciğer (A549) ve meme kanseri (MDA-MB-231) hücre hatlarında sodyum fenilpirüvatın antitümöral etkilerinin belirlenmesi amacıyla yapılmıştır. Araştırmada distile suyla sodyum fenilpirüvatın değişik yoğunluklarda çözeltileri hazırlandı. Bu çözeltilerden içerisinde 1x103 adet kanser hücresi bulunan mikropleyt kuyucuklarına sırasıyla kontrol, 0.0375 mM, 0.075 mM, 0.15 mM, 0.3 mM, 0.6 mM, 1.2 mM ve 2.4 mM’lik konsantrasyonlarından 100 mikrolitre hacimlerde ilave edildi. Aynı doz sağlıklı hücrelere de uygulandı. Her kuyucuğa 24, 48 ve 72. saatlerde CVDK-8 Cell Viability Test kitinden (Eco-Tech) 10’ar µL eklendi ve 1 saat sonra mikropleytlerin 450 nm dalga boyunda verdikleri absorbansları spektrofotometrede ölçülerek hücrelerin yoğunlukları belirlendi. Kontrol ve deney gruplarından elde edilen sonuçlar istatistiki yönden değerlendirildi. Deney gruplarda kontrole göre kanser hücre sayılarının azaldığı, hücre katlanma sayılarının ise arttığı tespit edildi. Kontrole göre en fazla azalma Akciğer Karsinom hücre hattında 2,4 mM dozda 24. saatte, Meme Adenokarsinom hücre hattında 2,4 mM dozda 72. saatte ve Human Umbilical Vein Endothelial Cells (HUVEC) hattında 1,2 mM dozda 48. saatte olduğu tespit edildi. Sodyum fenilpirüvatın akciğer ve meme kanseri hücreleri üzerine in vitro şartlarda antitümöral etki gösterdiği sonucuna varıldı.
{"title":"Investigation of the effects of sodium phenylpyruvate on pulmonary adenocarcinoma (A549) and mammary adenocarcinoma (MDA-MB-231) on cell lines","authors":"A. Doğan, A. Doğan","doi":"10.48138/cjo.979147","DOIUrl":"https://doi.org/10.48138/cjo.979147","url":null,"abstract":"Kanser tedavisinde son yıllarda başarı oranını artıran ilaç ve yöntemler geliştirilmiştir. Ancak toksisitesi düşük ve yüksek derecede etkili bir ilaç üretilememiştir. Bu araştırma akciğer (A549) ve meme kanseri (MDA-MB-231) hücre hatlarında sodyum fenilpirüvatın antitümöral etkilerinin belirlenmesi amacıyla yapılmıştır. Araştırmada distile suyla sodyum fenilpirüvatın değişik yoğunluklarda çözeltileri hazırlandı. Bu çözeltilerden içerisinde 1x103 adet kanser hücresi bulunan mikropleyt kuyucuklarına sırasıyla kontrol, 0.0375 mM, 0.075 mM, 0.15 mM, 0.3 mM, 0.6 mM, 1.2 mM ve 2.4 mM’lik konsantrasyonlarından 100 mikrolitre hacimlerde ilave edildi. Aynı doz sağlıklı hücrelere de uygulandı. Her kuyucuğa 24, 48 ve 72. saatlerde CVDK-8 Cell Viability Test kitinden (Eco-Tech) 10’ar µL eklendi ve 1 saat sonra mikropleytlerin 450 nm dalga boyunda verdikleri absorbansları spektrofotometrede ölçülerek hücrelerin yoğunlukları belirlendi. Kontrol ve deney gruplarından elde edilen sonuçlar istatistiki yönden değerlendirildi. Deney gruplarda kontrole göre kanser hücre sayılarının azaldığı, hücre katlanma sayılarının ise arttığı tespit edildi. Kontrole göre en fazla azalma Akciğer Karsinom hücre hattında 2,4 mM dozda 24. saatte, Meme Adenokarsinom hücre hattında 2,4 mM dozda 72. saatte ve Human Umbilical Vein Endothelial Cells (HUVEC) hattında 1,2 mM dozda 48. saatte olduğu tespit edildi. Sodyum fenilpirüvatın akciğer ve meme kanseri hücreleri üzerine in vitro şartlarda antitümöral etki gösterdiği sonucuna varıldı.","PeriodicalId":9662,"journal":{"name":"Caucasian Journal of Science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87601051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fen Bilimleri Dersi 5. Sınıf “Işığın Yayılması” Ünitesine Yönelik Başarı Testi Geliştirme Çalışması","authors":"Serkan Sevim, I. Uysal, Emine Demi̇rci̇","doi":"10.48138/cjo.644364","DOIUrl":"https://doi.org/10.48138/cjo.644364","url":null,"abstract":"","PeriodicalId":9662,"journal":{"name":"Caucasian Journal of Science","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89740557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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