Pub Date : 2026-03-07DOI: 10.1186/s11658-026-00894-z
Jennifer N Dulin, Li Ye, Teresa Grider, Anael Rizzo, Ephron S Rosenzweig, Janet Weber, Charu Ramakrishnan, Brian Hsueh, Karl Deisseroth, Mark H Tuszynski, Daniel Gibbs, Gunnar H D Poplawski
{"title":"Optimized genetic tracers for viral mediated neuronal projection mapping.","authors":"Jennifer N Dulin, Li Ye, Teresa Grider, Anael Rizzo, Ephron S Rosenzweig, Janet Weber, Charu Ramakrishnan, Brian Hsueh, Karl Deisseroth, Mark H Tuszynski, Daniel Gibbs, Gunnar H D Poplawski","doi":"10.1186/s11658-026-00894-z","DOIUrl":"https://doi.org/10.1186/s11658-026-00894-z","url":null,"abstract":"","PeriodicalId":9688,"journal":{"name":"Cellular & Molecular Biology Letters","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-28DOI: 10.1186/s11658-026-00861-8
Daixi Ren, Mei Yang, Yongzhen Mo, Qijia Yan, Lei Shi, Shanshan Zhang, Zhaojian Gong, Can Guo, Ming Zhou, Bo Xiang, Ming Tan, Guiyuan Li, Pan Chen, Wei Xiong, Zhaoyang Zeng
{"title":"Pseudouridine synthases upregulate 5'-tRF-Lys to inhibit YPEL3 and drive malignant progression in nasopharyngeal carcinoma.","authors":"Daixi Ren, Mei Yang, Yongzhen Mo, Qijia Yan, Lei Shi, Shanshan Zhang, Zhaojian Gong, Can Guo, Ming Zhou, Bo Xiang, Ming Tan, Guiyuan Li, Pan Chen, Wei Xiong, Zhaoyang Zeng","doi":"10.1186/s11658-026-00861-8","DOIUrl":"https://doi.org/10.1186/s11658-026-00861-8","url":null,"abstract":"","PeriodicalId":9688,"journal":{"name":"Cellular & Molecular Biology Letters","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-26DOI: 10.1186/s11658-026-00872-5
Meng Zou, Hongyu Wang, Xuhui Zeng, Xiaoning Zhang
All life processes depend on the precise spatiotemporal expression of genes, which involves orderly processes including transcription, posttranscriptional processing, translation, and posttranslational modification. Accumulating evidence demonstrates that Ca2+ is the most critical second messenger that orchestrates nearly all fundamental biological processes vital for maintaining normal physiological functions. Ca2+ homeostasis/signaling is primarily maintained through Ca2+ influx, cytoplasmic Ca2+ release, Ca2+ store cycling, and binding and release of Ca2+ buffers. Their coordinated interactions ensure that Ca2+ concentrations remain within the physiologically appropriate range. Ca2+ signaling must be appropriately activated or suppressed during cellular signal transduction to support specific functions, and its dysregulation can trigger various pathological conditions. This review summarizes recent progress in Ca2+ signaling regulatory networks, including the roles of key regulatory elements/toolkits, the functional significance of Ca2+ signals in different microdomains, and the influence of Ca2+ signaling on gene expression, along with the underlying mechanisms at various stages of gene expression. The involvement of Ca2+, both independently and collaboratively, in the nucleus, cytoplasm, subcellular microdomains such as mitochondria, and the extracellular space, in the multi-level regulation of gene expression, has been extensively studied. This information is essential for understanding the mechanisms underlying gene expression and for advancing the diagnosis and treatment of diseases. Finally, we propose forward-looking recommendations to address current research gaps, aiming to provide valuable references for researchers in this field.
{"title":"Gene expression regulation by Ca<sup>2+</sup> signaling: an updated systematic review.","authors":"Meng Zou, Hongyu Wang, Xuhui Zeng, Xiaoning Zhang","doi":"10.1186/s11658-026-00872-5","DOIUrl":"https://doi.org/10.1186/s11658-026-00872-5","url":null,"abstract":"<p><p>All life processes depend on the precise spatiotemporal expression of genes, which involves orderly processes including transcription, posttranscriptional processing, translation, and posttranslational modification. Accumulating evidence demonstrates that Ca<sup>2+</sup> is the most critical second messenger that orchestrates nearly all fundamental biological processes vital for maintaining normal physiological functions. Ca<sup>2+</sup> homeostasis/signaling is primarily maintained through Ca<sup>2+</sup> influx, cytoplasmic Ca<sup>2+</sup> release, Ca<sup>2+</sup> store cycling, and binding and release of Ca<sup>2+</sup> buffers. Their coordinated interactions ensure that Ca<sup>2+</sup> concentrations remain within the physiologically appropriate range. Ca<sup>2+</sup> signaling must be appropriately activated or suppressed during cellular signal transduction to support specific functions, and its dysregulation can trigger various pathological conditions. This review summarizes recent progress in Ca<sup>2+</sup> signaling regulatory networks, including the roles of key regulatory elements/toolkits, the functional significance of Ca<sup>2+</sup> signals in different microdomains, and the influence of Ca<sup>2+</sup> signaling on gene expression, along with the underlying mechanisms at various stages of gene expression. The involvement of Ca<sup>2+</sup>, both independently and collaboratively, in the nucleus, cytoplasm, subcellular microdomains such as mitochondria, and the extracellular space, in the multi-level regulation of gene expression, has been extensively studied. This information is essential for understanding the mechanisms underlying gene expression and for advancing the diagnosis and treatment of diseases. Finally, we propose forward-looking recommendations to address current research gaps, aiming to provide valuable references for researchers in this field.</p>","PeriodicalId":9688,"journal":{"name":"Cellular & Molecular Biology Letters","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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