Pub Date : 2022-12-29DOI: 10.26650/eurjbiol.2022.1168881
Dilara Kamer Çolak, Ufuk Ünal, S. Bolkent
{"title":"In silico Evaluation of WWC1 in Melanoma Using Bioinformatic Analyses","authors":"Dilara Kamer Çolak, Ufuk Ünal, S. Bolkent","doi":"10.26650/eurjbiol.2022.1168881","DOIUrl":"https://doi.org/10.26650/eurjbiol.2022.1168881","url":null,"abstract":"","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89051136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-21DOI: 10.26650/eurjbiol.2022.1163544
Gabriel Pereira, Emily Pereira Dos Santos, Maria Ruy Barbosa, S. Arioni, Thabata Caroline de Oliveira Santos, D. T. de Resende e Silva, J. H. Henao Agudelo, M. P. Pinho Franco, Ricardo Fernandez, Rafael Pereira, Danilo Souza de Almeida
{"title":"Thioredoxin-Interacting Protein: The Redoxissome Complex in Glomerular Lesion","authors":"Gabriel Pereira, Emily Pereira Dos Santos, Maria Ruy Barbosa, S. Arioni, Thabata Caroline de Oliveira Santos, D. T. de Resende e Silva, J. H. Henao Agudelo, M. P. Pinho Franco, Ricardo Fernandez, Rafael Pereira, Danilo Souza de Almeida","doi":"10.26650/eurjbiol.2022.1163544","DOIUrl":"https://doi.org/10.26650/eurjbiol.2022.1163544","url":null,"abstract":"","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81958132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.26650/eurjbiol.2022.1167842
İrem Ürkmez, Hatice Karahan Coven, Aslı Eldem, M. Pehlivan
Objective: Current approaches focus on the use of natural compounds in plants in the treatment of cancer. Trigonella foenum (Fenugreek) is mainly used in medicine, food, and cosmetics due to its bioactive and aromatic compounds. Many compounds with medicinal effects are found in Fenugreek seeds. These compounds have been demonstrated to be effective on numerous cancer cells. Neuroblastoma is one of the most common extracranial solid malignancies in children. In our study, the effects of Fenugreek on cell cytotoxicity, cell damage, migration, and sphere formation in neuroblastoma cells were investigated. Materials and Methods: The powder extract was dissolved in DMEM and filtered to prepare a stock solution of Fenugreek. We used MTT assay for the detection of cytotoxic effects of Fenugreek on SH-SY5Y cells, crystal violet staining for the analysis of morphological change in cells, wound healing test for the cell migration analysis, and agarose gel electrophoresis for detecting DNA damage. We created a spheroid to test the effect we observed in 2D culture, in 3D culture as well. Results: The findings of our study showed that Fenugreek treatments caused significant reductions in cell proliferation and migration capacities in 2D neuroblastoma cells at IC 50 (1500 μg/ml) doses, respectively. In addition Fenugreek changed cell morphology and increased DNA fragmentation. Furthermore, Fenugreek caused disruption of 3D spheroid formation of SHSY-5Y cells in a dose- and time-dependent manner. Conclusion: The determination of the anti-cancer effect of Fenugreek on neuroblastoma cancer may be a useful and feasible intervention in neuroblastoma patients in the light of further studies and with the help of new nano drug delivery systems.
{"title":"Anti-Cancer Effects of Trigonella foenum in Neuroblastoma Cell Line","authors":"İrem Ürkmez, Hatice Karahan Coven, Aslı Eldem, M. Pehlivan","doi":"10.26650/eurjbiol.2022.1167842","DOIUrl":"https://doi.org/10.26650/eurjbiol.2022.1167842","url":null,"abstract":"Objective: Current approaches focus on the use of natural compounds in plants in the treatment of cancer. Trigonella foenum (Fenugreek) is mainly used in medicine, food, and cosmetics due to its bioactive and aromatic compounds. Many compounds with medicinal effects are found in Fenugreek seeds. These compounds have been demonstrated to be effective on numerous cancer cells. Neuroblastoma is one of the most common extracranial solid malignancies in children. In our study, the effects of Fenugreek on cell cytotoxicity, cell damage, migration, and sphere formation in neuroblastoma cells were investigated. Materials and Methods: The powder extract was dissolved in DMEM and filtered to prepare a stock solution of Fenugreek. We used MTT assay for the detection of cytotoxic effects of Fenugreek on SH-SY5Y cells, crystal violet staining for the analysis of morphological change in cells, wound healing test for the cell migration analysis, and agarose gel electrophoresis for detecting DNA damage. We created a spheroid to test the effect we observed in 2D culture, in 3D culture as well. Results: The findings of our study showed that Fenugreek treatments caused significant reductions in cell proliferation and migration capacities in 2D neuroblastoma cells at IC 50 (1500 μg/ml) doses, respectively. In addition Fenugreek changed cell morphology and increased DNA fragmentation. Furthermore, Fenugreek caused disruption of 3D spheroid formation of SHSY-5Y cells in a dose- and time-dependent manner. Conclusion: The determination of the anti-cancer effect of Fenugreek on neuroblastoma cancer may be a useful and feasible intervention in neuroblastoma patients in the light of further studies and with the help of new nano drug delivery systems.","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90224564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.26650/eurjbiol.2022.1195227
Turgay Durmuş, N. Balkıs, S. Tas, Fatma Bayram Partal, M. Balcı, C. Dalyan, M. Sari
{"title":"New Records for Microalgae Species of the Turkish Seas Under the Effect of Intense Mucilage in the Sea of Marmara","authors":"Turgay Durmuş, N. Balkıs, S. Tas, Fatma Bayram Partal, M. Balcı, C. Dalyan, M. Sari","doi":"10.26650/eurjbiol.2022.1195227","DOIUrl":"https://doi.org/10.26650/eurjbiol.2022.1195227","url":null,"abstract":"","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78139807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.26650/eurjbiol.2022.1191701
Pınar Obakan Yerlİkaya, Shafaq Naxmedova
{"title":"Epibrassinolide Triggers Apoptotic Cell Death in SK-N-AS Neuroblastoma Cells by Targeting GSK3β in a ROS Generation-Dependent Way","authors":"Pınar Obakan Yerlİkaya, Shafaq Naxmedova","doi":"10.26650/eurjbiol.2022.1191701","DOIUrl":"https://doi.org/10.26650/eurjbiol.2022.1191701","url":null,"abstract":"","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76150474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.26650/eurjbiol.2022.1148934
M. Acikel Elmas, G. Özgün, Özlem BİNGÖL ÖZAKPINAR, Zozan Guleken, S. Arbak
{"title":"Effects of Apocynin against Monosodium Glutamate-Induced Oxidative Damage in Rat Kidne","authors":"M. Acikel Elmas, G. Özgün, Özlem BİNGÖL ÖZAKPINAR, Zozan Guleken, S. Arbak","doi":"10.26650/eurjbiol.2022.1148934","DOIUrl":"https://doi.org/10.26650/eurjbiol.2022.1148934","url":null,"abstract":"","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78916688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-02DOI: 10.26650/eurjbiol.2021.1110344
B. Dalbayrak, Mustafa Metiner
{"title":"Personalized Medicine: A Solution for Today and Tomorrow","authors":"B. Dalbayrak, Mustafa Metiner","doi":"10.26650/eurjbiol.2021.1110344","DOIUrl":"https://doi.org/10.26650/eurjbiol.2021.1110344","url":null,"abstract":"","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90346551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-02DOI: 10.26650/eurjbiol.2022.1111191
Fatma Kanpalta, B. Ertaş, A. Şen, D. Akakın, G. Şener, F. Ercan
{"title":"Myrtus communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation","authors":"Fatma Kanpalta, B. Ertaş, A. Şen, D. Akakın, G. Şener, F. Ercan","doi":"10.26650/eurjbiol.2022.1111191","DOIUrl":"https://doi.org/10.26650/eurjbiol.2022.1111191","url":null,"abstract":"","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73860399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-24DOI: 10.26650/eurjbiol.2022.1097938
N. Hanachi, L. Arrar
{"title":"Inflammation Parameters, Xanthine Oxidase and Anti-Xanthine Oxidase Antibodies in Synovial Fluid of Patients Suffering from Arthritis","authors":"N. Hanachi, L. Arrar","doi":"10.26650/eurjbiol.2022.1097938","DOIUrl":"https://doi.org/10.26650/eurjbiol.2022.1097938","url":null,"abstract":"","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86971237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-23DOI: 10.26650/eurjbiol.2022.1164864
Şeref Gül
{"title":"In Silico Analysis of BMAL1 and CLOCK SNPs in the Ensembl Database","authors":"Şeref Gül","doi":"10.26650/eurjbiol.2022.1164864","DOIUrl":"https://doi.org/10.26650/eurjbiol.2022.1164864","url":null,"abstract":"","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86780236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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