Pub Date : 2022-01-27DOI: 10.26650/eurjbiol.2021.1011530
Ayşenur Kayabaş, E. Yıldırım
Objective: Salvia absconditiflora Greuter & Burdet is an endemic plant and survives in nature by adapting to extreme conditions. The aims of this study are to characterize and compare the diversity in the spectral-chemical structure of S. absconditiflora’s plant parts using the FTIR spectroscopy technique, to determine the wettability of the adaxial and abaxial epidermal surfaces of S. abscontidiflora leaves and to interpret whether there is a difference between the contact angle (CA) measurements at the points determined in the surface area of the leaves from the part close to the petiole to the leaf tip. Materials and Methods: The ATR-FTIR spectra for the chemical content of S. absconditiflora were obtained from six different plant parts and information about their chemical compositions was obtained. CA measurements were carried out for the natural events of the leaf area, especially for the water holding capacity or hydrophilic-hydrophobic characteristics. Results: The biochemical fingerprint of S. absconditiflora was determined by the analysis of chemical groups in vegetative and generative plant parts using ATR-FTIR spectroscopy. The CAs showed that the leaf had a hydrophobic character. In addition, leaf hysteresis was determined for each plant part, and it was understood that the lotus effect also appeared in S. absconditiflora. Conclusion: Detailed biochemical profiling, wettability, and hysteresis reports of S. absconditiflora were created for the first time. With this study, important clues about the adaptation of plants to harsh conditions were obtained.
{"title":"Chemical Profiling and Wetting Behaviors of Endemic Salvia absconditiflora Greuter & Burdet (Lamiaceae) Collected from Gypsum Areas","authors":"Ayşenur Kayabaş, E. Yıldırım","doi":"10.26650/eurjbiol.2021.1011530","DOIUrl":"https://doi.org/10.26650/eurjbiol.2021.1011530","url":null,"abstract":"Objective: Salvia absconditiflora Greuter & Burdet is an endemic plant and survives in nature by adapting to extreme conditions. The aims of this study are to characterize and compare the diversity in the spectral-chemical structure of S. absconditiflora’s plant parts using the FTIR spectroscopy technique, to determine the wettability of the adaxial and abaxial epidermal surfaces of S. abscontidiflora leaves and to interpret whether there is a difference between the contact angle (CA) measurements at the points determined in the surface area of the leaves from the part close to the petiole to the leaf tip. Materials and Methods: The ATR-FTIR spectra for the chemical content of S. absconditiflora were obtained from six different plant parts and information about their chemical compositions was obtained. CA measurements were carried out for the natural events of the leaf area, especially for the water holding capacity or hydrophilic-hydrophobic characteristics. Results: The biochemical fingerprint of S. absconditiflora was determined by the analysis of chemical groups in vegetative and generative plant parts using ATR-FTIR spectroscopy. The CAs showed that the leaf had a hydrophobic character. In addition, leaf hysteresis was determined for each plant part, and it was understood that the lotus effect also appeared in S. absconditiflora. Conclusion: Detailed biochemical profiling, wettability, and hysteresis reports of S. absconditiflora were created for the first time. With this study, important clues about the adaptation of plants to harsh conditions were obtained.","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77176276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tehreem Khalil, Samman Samman, Z. Jawad, Zunaira Hakeem, Aemin Rasheed, Fareeha Sohail, Iqra Asad, Shehreen Sohail, Hamza Rana, S. Saleem
Exploring host-HTLV-1 interactions and the molecular processes underpinning HTLV-1-mediated carcinogenesis is crucial for establishing effective treatments for viral infection and associated leukemia/lymphoma. Several HTLV-1 proteins have been shown to play important roles in the cellular transformation and immortalization of infected T cells. Through interactions with MAVS, STING, and RIP1, the HTLV-1 oncoprotein Tax suppresses the innate IFN response, resulting in the inhibition of TBK1-mediated phosphorylation of IRF3/IRF7. The HTLV-1 protein HBZ affects genomic integrity and inhibits target cell death and autophagy. Furthermore, it has been discovered that HBZ promotes the growth of ATL cells and aids in the evasion of infected cells from immunosurveillance. It currently appears that the efficacy of an individual's cytotoxic T cell (CTL) response to HTLV-1 is the most important single predictor of that person's provirus load, which can differ by more than 10,000-fold amongst HTLV-1-infected persons. We examine recent improvements in our knowledge of the pathophysiology, or underlying processes, of the illness produced by HTLV-1 infection in this article. Furthermore, we explore the future approach for targeting HTLV-1-associated malignancies and anti-HTLV-1 therapies. The pathogenic agent of adult T-cell leukemia/lymphoma (ATL) is human T-cell lymphotropic virus type 1 (HTLV-1). ATL is a fast-developing clonal tumour of CD4+ T cells which are cellular and viral protein interactions and pave the way for the discovery of new classes of cellular modulators, which may induce Tax oncogenesis and its impact on survival signalling pathways such as the NF-B and PI3K-Akt pathways, therapeutic target opportunities for ATL have been presented in two collaborative studies.
{"title":"Human T-cell lymphotropic virus type 1 oncogenesis and cell-to-cell spread","authors":"Tehreem Khalil, Samman Samman, Z. Jawad, Zunaira Hakeem, Aemin Rasheed, Fareeha Sohail, Iqra Asad, Shehreen Sohail, Hamza Rana, S. Saleem","doi":"10.47672/ejb.913","DOIUrl":"https://doi.org/10.47672/ejb.913","url":null,"abstract":"Exploring host-HTLV-1 interactions and the molecular processes underpinning HTLV-1-mediated carcinogenesis is crucial for establishing effective treatments for viral infection and associated leukemia/lymphoma. Several HTLV-1 proteins have been shown to play important roles in the cellular transformation and immortalization of infected T cells. Through interactions with MAVS, STING, and RIP1, the HTLV-1 oncoprotein Tax suppresses the innate IFN response, resulting in the inhibition of TBK1-mediated phosphorylation of IRF3/IRF7. The HTLV-1 protein HBZ affects genomic integrity and inhibits target cell death and autophagy. Furthermore, it has been discovered that HBZ promotes the growth of ATL cells and aids in the evasion of infected cells from immunosurveillance. It currently appears that the efficacy of an individual's cytotoxic T cell (CTL) response to HTLV-1 is the most important single predictor of that person's provirus load, which can differ by more than 10,000-fold amongst HTLV-1-infected persons. We examine recent improvements in our knowledge of the pathophysiology, or underlying processes, of the illness produced by HTLV-1 infection in this article. Furthermore, we explore the future approach for targeting HTLV-1-associated malignancies and anti-HTLV-1 therapies. The pathogenic agent of adult T-cell leukemia/lymphoma (ATL) is human T-cell lymphotropic virus type 1 (HTLV-1). ATL is a fast-developing clonal tumour of CD4+ T cells which are cellular and viral protein interactions and pave the way for the discovery of new classes of cellular modulators, which may induce Tax oncogenesis and its impact on survival signalling pathways such as the NF-B and PI3K-Akt pathways, therapeutic target opportunities for ATL have been presented in two collaborative studies.","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84338774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-15DOI: 10.26650/eurjbiol.2021.1023136
B. Ertaş, F. Turan, Dilek Özbeyli, R. Yanardağ, Özlem Saçan, G. Şener
{"title":"Protective Effects of Petroselinum crispum (Parsley) Extract Against Methotrexate-Induced Hepatotoxicity","authors":"B. Ertaş, F. Turan, Dilek Özbeyli, R. Yanardağ, Özlem Saçan, G. Şener","doi":"10.26650/eurjbiol.2021.1023136","DOIUrl":"https://doi.org/10.26650/eurjbiol.2021.1023136","url":null,"abstract":"","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77576795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-15DOI: 10.26650/eurjbiol.2021.1026981
Yeter Yeşil Cantürk, F. Özhatay
Objective: Polygonatum (Asparagaceae) is a rhizomatous monocotyledon genus that is distributed in the temperate regions of the Northern Hemisphere. The genus is represented by 5 species in Turkey (P. glaberrimum, P. latifolium, P. multiflorum, P. verticillatum and P. orientale). Karyological, palynological, phylogenic, chemotaxonomical and some anatomical studies of Polygonatum species have been carried out previously. However, the detailed anatomical features of the scape, rhizome and root of Polygonatum species grown in Turkey have not been examined before and so the aim of this study is to determine their anatomical characteristics. Also, the study compares the species with each other according to obtained anatomical characteristics and comparing them with previous anatomical studies. Materials and Methods: Investigations were carried out on fresh material collected from wild habitats during July 20092012 in Turkey. Cross-sections of scape, rhizome and roots were cut by hand, detailed photographs were taken under a light microscope, and anatomical structures were drawn in detail with an isograph pen. Results: The anatomical structures of Polygonatum species have monocotyledones features. Significant differences between species were observed, such as the number of costas in the scape, number of xylem arms in the root and the types of vascular bundle in the rhizome. Also, the anatomical characteristics of the species were compared with previous anatomical studies. Conclusion: The anatomical features determined by this study will be useful at the species level as well as at the genus and family level. Hence the obtained data will contribute to the literature.
{"title":"Scape, Rhizome and Root Anatomy of Polygonatum Species from Turkey","authors":"Yeter Yeşil Cantürk, F. Özhatay","doi":"10.26650/eurjbiol.2021.1026981","DOIUrl":"https://doi.org/10.26650/eurjbiol.2021.1026981","url":null,"abstract":"Objective: Polygonatum (Asparagaceae) is a rhizomatous monocotyledon genus that is distributed in the temperate regions of the Northern Hemisphere. The genus is represented by 5 species in Turkey (P. glaberrimum, P. latifolium, P. multiflorum, P. verticillatum and P. orientale). Karyological, palynological, phylogenic, chemotaxonomical and some anatomical studies of Polygonatum species have been carried out previously. However, the detailed anatomical features of the scape, rhizome and root of Polygonatum species grown in Turkey have not been examined before and so the aim of this study is to determine their anatomical characteristics. Also, the study compares the species with each other according to obtained anatomical characteristics and comparing them with previous anatomical studies. Materials and Methods: Investigations were carried out on fresh material collected from wild habitats during July 20092012 in Turkey. Cross-sections of scape, rhizome and roots were cut by hand, detailed photographs were taken under a light microscope, and anatomical structures were drawn in detail with an isograph pen. Results: The anatomical structures of Polygonatum species have monocotyledones features. Significant differences between species were observed, such as the number of costas in the scape, number of xylem arms in the root and the types of vascular bundle in the rhizome. Also, the anatomical characteristics of the species were compared with previous anatomical studies. Conclusion: The anatomical features determined by this study will be useful at the species level as well as at the genus and family level. Hence the obtained data will contribute to the literature.","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90670577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-14DOI: 10.26650/eurjbiol.2021.1028656
B. Bayrak, R. Yanardağ
Objective: Eremurus spectabilis M. Bieb. is grown in East and Southeast Mediterranean regions of Turkey, and is commonly used as an edible plant in these regions. The aim of the current study was to determine the antioxidant activities of different E. spectabilis M. Bieb. extracts and some sulfur compounds. Materials and Methods: In this study, the antioxidant activities of aqueous, ethanolic, and ethyl acetate extracts of E. spectabilis M. Bieb. and sulfur compounds (α-lipoic acid, cysteamine, cysteine, diallyl sulfide, glutathione, homocysteine, N-acetyl cysteine, vitamin U and 1,4-dithioerythritol) were assessed in several antioxidant tests. These tests included reducing power, cupric ion reducing antioxidant capacity, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging, 2,2-diphenyl-1-picrylhydrazyl radical scavenging, N,N-dimethyl-4-phenylenediamine dihydrochloride radical scavenging, superoxide anion radical scavenging, hydroxyl radical scavenging, metal chelating activities and ferric ion reducing antioxidant power. The phytochemical profiles and total phenolic and flavonoid contents of all extracts were investigated. Results: It was found out that the antioxidant activities of all the extracts and sulfur compounds generally increased with concentration increases, the highest antioxidant activity was found in ethyl acetate extract, while the aqueous extract was found to have the lowest antioxidant activity. Diallyl sulfide was found to have the highest antioxidant activity, whereas vitamin U had the lowest antioxidant activity. It was observed that all extracts of E. spectabilis M. Bieb. and the sulfur compounds showed antioxidant activity. Conclusion: The E. spectabilis M. Bieb. and sulfur compounds investigated in this study could be considered as a source of antioxidants.
{"title":"Antioxidant Activities of Eremurus spectabilis M. Bieb. Extracts and Sulfur Compounds","authors":"B. Bayrak, R. Yanardağ","doi":"10.26650/eurjbiol.2021.1028656","DOIUrl":"https://doi.org/10.26650/eurjbiol.2021.1028656","url":null,"abstract":"Objective: Eremurus spectabilis M. Bieb. is grown in East and Southeast Mediterranean regions of Turkey, and is commonly used as an edible plant in these regions. The aim of the current study was to determine the antioxidant activities of different E. spectabilis M. Bieb. extracts and some sulfur compounds. Materials and Methods: In this study, the antioxidant activities of aqueous, ethanolic, and ethyl acetate extracts of E. spectabilis M. Bieb. and sulfur compounds (α-lipoic acid, cysteamine, cysteine, diallyl sulfide, glutathione, homocysteine, N-acetyl cysteine, vitamin U and 1,4-dithioerythritol) were assessed in several antioxidant tests. These tests included reducing power, cupric ion reducing antioxidant capacity, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging, 2,2-diphenyl-1-picrylhydrazyl radical scavenging, N,N-dimethyl-4-phenylenediamine dihydrochloride radical scavenging, superoxide anion radical scavenging, hydroxyl radical scavenging, metal chelating activities and ferric ion reducing antioxidant power. The phytochemical profiles and total phenolic and flavonoid contents of all extracts were investigated. Results: It was found out that the antioxidant activities of all the extracts and sulfur compounds generally increased with concentration increases, the highest antioxidant activity was found in ethyl acetate extract, while the aqueous extract was found to have the lowest antioxidant activity. Diallyl sulfide was found to have the highest antioxidant activity, whereas vitamin U had the lowest antioxidant activity. It was observed that all extracts of E. spectabilis M. Bieb. and the sulfur compounds showed antioxidant activity. Conclusion: The E. spectabilis M. Bieb. and sulfur compounds investigated in this study could be considered as a source of antioxidants.","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89262922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-09DOI: 10.26650/eurjbiol.2021.1017807
M. Tüzüner, A. Ceviz
{"title":"Proteomic Analysis Revealed Underlying Biological Pathways Associated with Hormetic Response of Hormone Positive Breast Cancer Cell Line Exposed to Low-Dose Flavonoid Mixture","authors":"M. Tüzüner, A. Ceviz","doi":"10.26650/eurjbiol.2021.1017807","DOIUrl":"https://doi.org/10.26650/eurjbiol.2021.1017807","url":null,"abstract":"","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72899821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-07DOI: 10.26650/eurjbiol.2021.1018938
I. Eryilmaz, G. Güney Eskiler, Ceyda Çolakoğlu, Ü. Egelí, G. Cecener
{"title":"The Activation of PI3K/AKT/mTOR Signaling Pathway in Response to Cabazitaxel Treatment in Metastatic Castration-Resistant Prostate Cancer Cells","authors":"I. Eryilmaz, G. Güney Eskiler, Ceyda Çolakoğlu, Ü. Egelí, G. Cecener","doi":"10.26650/eurjbiol.2021.1018938","DOIUrl":"https://doi.org/10.26650/eurjbiol.2021.1018938","url":null,"abstract":"","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77383677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-07DOI: 10.26650/eurjbiol.2021.1010029
Burcu Saygıdeğer Demir, Aycan Sezan, Ezgi Derinöz, E. Nas, Mehmet Özerten, G. Mahmoudi, Y. Saygıdeğer
{"title":"Antitumoral Properties of a Pincer-Type Isonicotinohydrazone-Hg(II) Complex","authors":"Burcu Saygıdeğer Demir, Aycan Sezan, Ezgi Derinöz, E. Nas, Mehmet Özerten, G. Mahmoudi, Y. Saygıdeğer","doi":"10.26650/eurjbiol.2021.1010029","DOIUrl":"https://doi.org/10.26650/eurjbiol.2021.1010029","url":null,"abstract":"","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82296976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-06DOI: 10.26650/eurjbiol.2021.1016222
Dilek Özbeyli, A. Şen, A. Aykaç, K. Teralı, Ö. Ç. Çilingir Kaya, Ismail Senkardes, G. Şener
{"title":"Therapeutic Effects of Momordica charantia L. Ethanolic Extract on Acetic Acid-Induced Ulcerative Colitis in Rats","authors":"Dilek Özbeyli, A. Şen, A. Aykaç, K. Teralı, Ö. Ç. Çilingir Kaya, Ismail Senkardes, G. Şener","doi":"10.26650/eurjbiol.2021.1016222","DOIUrl":"https://doi.org/10.26650/eurjbiol.2021.1016222","url":null,"abstract":"","PeriodicalId":9711,"journal":{"name":"Central European Journal of Biology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83854339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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