Pub Date : 2024-05-05DOI: 10.1101/2023.04.22.537920
Erica C Dresselhaus, Kathryn P Harris, Cassandra R Blanchette, Kate Koles, Steven J Del Signore, Matthew F Pescosolido, Biljana Ermanoska, Mark Rozencwaig, Rebecca C Soslowsky, Michael J Parisi, Bryan A Stewart, Timothy J Mosca, Avital A Rodal
Extracellular vesicles (EVs) are released by many cell types including neurons, carrying cargoes involved in signaling and disease. It is unclear whether EVs promote intercellular signaling or serve primarily to dispose of unwanted materials. We show that loss of multivesicular endosome-generating ESCRT (endosomal sorting complex required for transport) machinery disrupts release of EV cargoes from Drosophila motor neurons. Surprisingly, ESCRT depletion does not affect the signaling activities of the EV cargo Synaptotagmin-4 (Syt4) and disrupts only some signaling activities of the EV cargo Evenness Interrupted (Evi). Thus, these cargoes may not require intercellular transfer via EVs, and instead may be conventionally secreted or function cell autonomously in the neuron. We find that EVs are phagocytosed by glia and muscles, and that ESCRT disruption causes compensatory autophagy in presynaptic neurons, suggesting that EVs are one of several redundant mechanisms to remove cargoes from synapses. Our results suggest that synaptic EV release serves primarily as a proteostatic mechanism for certain cargoes.
{"title":"ESCRT disruption provides evidence against transsynaptic signaling functions for extracellular vesicles.","authors":"Erica C Dresselhaus, Kathryn P Harris, Cassandra R Blanchette, Kate Koles, Steven J Del Signore, Matthew F Pescosolido, Biljana Ermanoska, Mark Rozencwaig, Rebecca C Soslowsky, Michael J Parisi, Bryan A Stewart, Timothy J Mosca, Avital A Rodal","doi":"10.1101/2023.04.22.537920","DOIUrl":"10.1101/2023.04.22.537920","url":null,"abstract":"<p><p>Extracellular vesicles (EVs) are released by many cell types including neurons, carrying cargoes involved in signaling and disease. It is unclear whether EVs promote intercellular signaling or serve primarily to dispose of unwanted materials. We show that loss of multivesicular endosome-generating ESCRT (endosomal sorting complex required for transport) machinery disrupts release of EV cargoes from <i>Drosophila</i> motor neurons. Surprisingly, ESCRT depletion does not affect the signaling activities of the EV cargo Synaptotagmin-4 (Syt4) and disrupts only some signaling activities of the EV cargo Evenness Interrupted (Evi). Thus, these cargoes may not require intercellular transfer via EVs, and instead may be conventionally secreted or function cell autonomously in the neuron. We find that EVs are phagocytosed by glia and muscles, and that ESCRT disruption causes compensatory autophagy in presynaptic neurons, suggesting that EVs are one of several redundant mechanisms to remove cargoes from synapses. Our results suggest that synaptic EV release serves primarily as a proteostatic mechanism for certain cargoes.</p>","PeriodicalId":9748,"journal":{"name":"Chemical and Petroleum Engineering","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11092503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73196410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-14DOI: 10.1007/s10556-023-01248-8
E. A. Pavlyuchenko, S. Yu. Kaigorodov, V. E. Shcherba
{"title":"High-Diodeness Vortex Hydrodiode","authors":"E. A. Pavlyuchenko, S. Yu. Kaigorodov, V. E. Shcherba","doi":"10.1007/s10556-023-01248-8","DOIUrl":"https://doi.org/10.1007/s10556-023-01248-8","url":null,"abstract":"","PeriodicalId":9748,"journal":{"name":"Chemical and Petroleum Engineering","volume":"21 20","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134991225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-14DOI: 10.1007/s10556-023-01246-w
A. V. Grigoriev, E. A. Pavlyuchenko, S. Yu. Kaigorodov, K. N. Sokirko
{"title":"Comprehensive Assessment of Pulsation Phenomena and Dynamic Loads in the Working Elements of a Hydraulic Drive","authors":"A. V. Grigoriev, E. A. Pavlyuchenko, S. Yu. Kaigorodov, K. N. Sokirko","doi":"10.1007/s10556-023-01246-w","DOIUrl":"https://doi.org/10.1007/s10556-023-01246-w","url":null,"abstract":"","PeriodicalId":9748,"journal":{"name":"Chemical and Petroleum Engineering","volume":"6 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136228719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1007/s10556-023-01235-z
R. E. Kobylskiy, S. S. Busarov
{"title":"Predicting the Service Life of Cylinder-Piston Seals of Reciprocating Compressors","authors":"R. E. Kobylskiy, S. S. Busarov","doi":"10.1007/s10556-023-01235-z","DOIUrl":"https://doi.org/10.1007/s10556-023-01235-z","url":null,"abstract":"","PeriodicalId":9748,"journal":{"name":"Chemical and Petroleum Engineering","volume":"46 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136346381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1007/s10556-023-01242-0
Yu. Ya. Pechenegov
{"title":"Comparison of Heat-Transfer Energy Efficiency for Direct and Swirl Pipe Flows","authors":"Yu. Ya. Pechenegov","doi":"10.1007/s10556-023-01242-0","DOIUrl":"https://doi.org/10.1007/s10556-023-01242-0","url":null,"abstract":"","PeriodicalId":9748,"journal":{"name":"Chemical and Petroleum Engineering","volume":"48 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136346375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1007/s10556-023-01236-y
N. G. Dudkina, I. N. Zakharov, V. V. Barinov
{"title":"Influence of the Chemical Composition of Steel on the Heat Resistance of a Surface Layer Subjected to Combined Hardening Treatment with Electromechanical Treatment + Surface Plastic Deformation","authors":"N. G. Dudkina, I. N. Zakharov, V. V. Barinov","doi":"10.1007/s10556-023-01236-y","DOIUrl":"https://doi.org/10.1007/s10556-023-01236-y","url":null,"abstract":"","PeriodicalId":9748,"journal":{"name":"Chemical and Petroleum Engineering","volume":"49 21","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134992753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-13DOI: 10.1007/s10556-023-01245-x
A. B. Vandyshev, V. A. Kulikov
{"title":"Effect of Membrane Thickness on Parameters for Producing High-Purity Hydrogen from Hydrocarbon Raw Materials in Membrane-Catalytic Devices","authors":"A. B. Vandyshev, V. A. Kulikov","doi":"10.1007/s10556-023-01245-x","DOIUrl":"https://doi.org/10.1007/s10556-023-01245-x","url":null,"abstract":"","PeriodicalId":9748,"journal":{"name":"Chemical and Petroleum Engineering","volume":"53 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136347623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-11DOI: 10.1007/s10556-023-01241-1
V. E. Zinurov, A. V. Dmitriev, A. A. Abdullina, E. I. Salakhova, O. S. Dmitrieva
{"title":"Separating Device for Capturing Fine Particles Formed During Operation of Fluidized Bed Reactors","authors":"V. E. Zinurov, A. V. Dmitriev, A. A. Abdullina, E. I. Salakhova, O. S. Dmitrieva","doi":"10.1007/s10556-023-01241-1","DOIUrl":"https://doi.org/10.1007/s10556-023-01241-1","url":null,"abstract":"","PeriodicalId":9748,"journal":{"name":"Chemical and Petroleum Engineering","volume":"47 22","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135042982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-11DOI: 10.1007/s10556-023-01232-2
I. A. Rastegaev, A. K. Khrustalev, I. I. Rastegaeva, P. N. Zorin
{"title":"Features of Localization of Sodium Hydroxide Solution Leakage Using Acoustic Emission Method","authors":"I. A. Rastegaev, A. K. Khrustalev, I. I. Rastegaeva, P. N. Zorin","doi":"10.1007/s10556-023-01232-2","DOIUrl":"https://doi.org/10.1007/s10556-023-01232-2","url":null,"abstract":"","PeriodicalId":9748,"journal":{"name":"Chemical and Petroleum Engineering","volume":"48 14","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135042969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-11DOI: 10.1007/s10556-023-01233-1
V. P. Zayarnyi, Yu.V. Pastukhov, I. L. Gonik
{"title":"Mathematical Substantiation of the Monitoring of Corrosion Processes in Process Equipment by Radiometric Method","authors":"V. P. Zayarnyi, Yu.V. Pastukhov, I. L. Gonik","doi":"10.1007/s10556-023-01233-1","DOIUrl":"https://doi.org/10.1007/s10556-023-01233-1","url":null,"abstract":"","PeriodicalId":9748,"journal":{"name":"Chemical and Petroleum Engineering","volume":"31 16","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135041789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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