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Transient cerebral salt wasting following scrub typhus infection- A case report. 恙虫病感染后短暂性脑盐消耗1例报告。
IF 0.4 Pub Date : 2022-06-30 DOI: 10.4038/cmj.v67i2.9634
Kingsley Rajivasan Francis, Ranjan Premarathna

Cerebral salt wasting (hyponatraemia associated with renal sodium loss and hypovolumia) has been reported secondary to intra-cerebral pathology and following certain infections. Cerebral salt wasting following typhus infection has been reported rarely. We report a case of transient cerebral salt wasting that occurred during the convalescent phase of scrub typhus infection resulting in severe symptomatic hyponatraemia.

脑盐消耗(低钠血症伴肾钠流失和低血容量)已被报道继发于脑内病理和某些感染。斑疹伤寒感染后脑盐消耗的报道很少。我们报告一例短暂的脑盐消耗,发生在恢复期的恙虫病感染,导致严重的症状性低钠血症。
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引用次数: 1
INCIDENTAL THYROID CANCER IN THE PYRAMIDAL LOBE & IMPLICATIONS FOR THYROIDECTOMY. 锥体叶偶发甲状腺癌及甲状腺切除术的意义。
IF 0.4 Pub Date : 2022-06-30 DOI: 10.4038/cmj.v67i2.9633
Diluka Pinto, Gayana Mahendra, Ranil Fernando

The Embryological remnants (ERs) must be removed to achieve a safe and complete 'total' thyroidectomy. Residual ERs, after thyroidectomy, may cause recurrence of the initial pathology. This poses management dilemmas, including a difficult reoperation. Active search and removal of the ERs intraoperatively is essential. Primary overt malignancy is rare in ERs. Literature reports several cohort studies of same. The incidence of a Micropapillary Carcinoma in an ER has not been reported and this brief report describes two patients with Incidental Micropapillary Carcinoma in the Pyramidal lobe, reiterating the need to make removal of ERs the accepted norm in total thyroidectomies.

为了实现安全、完整的“全”甲状腺切除术,必须切除胚胎残余(er)。甲状腺切除术后残留的er可引起初始病理复发。这造成了管理困境,包括困难的再操作。术中主动搜索和移除急诊室是必要的。原发性显性恶性肿瘤在急诊中是罕见的。文献报道了几项相同的队列研究。微乳头状癌在ER中的发病率尚未报道,本文简要描述了两例锥体叶偶发微乳头状癌的患者,重申了在全甲状腺切除术中切除ER的必要性。
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引用次数: 0
Sarcopenia: clinical consequences and management. 骨骼肌减少症:临床后果和管理。
IF 0.4 Pub Date : 2022-06-30 DOI: 10.4038/cmj.v67i2.9627
Sarath Lekamwasam
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引用次数: 0
Nutrition-related parameters of maintenance haemodialysis patients. 维持性血液透析患者的营养相关参数。
IF 0.4 Pub Date : 2022-06-30 DOI: 10.4038/cmj.v67i2.9631
Hashan Kawshalya Amarathunga, Jayamini Pathiraja, Ayodya Sadamali Kariyawasam, Duminda Basnayaka

Background & aim: Maintaining good health in haemodialysis patients is a challenging task that helps to reduce morbidity and mortality. The prevalence of nutrition-related complications is uncertain in Sri Lankan maintenance haemodialysis population. This study was carried out as a baseline study to identify the common nutrition-related complications in maintenance haemodialysis patients.

Methods: A single-centre cross-sectional study was carried out on adult patients on maintenance haemodialysis in a tertiary care centre in the central part of Sri Lanka. Simple random sampling was used, and patients' clinical, anthropometric, body composition via bioelectrical impedance analysis (BIA), laboratory parameters and muscle power were assessed.

Results: We evaluated 114 patients, 87 (76.3%) were males, and the mean age was 52.6 (±12.3) years. Only 9 (7.9%) patients were underweight in the sample population, 77.2% had normal mid-upper arm circumference (MUAC), 81.6% had high muscle mass percentage in BIA analysis, and all patients had normal mid-arm muscle circumference (MAMC). But in 80.5% of patients hand grip power was lower than the cut off for sarcopenia according to EWGSOP2 recommendations. The prevalence of low serum albumin is 33.3% and 60.5% had anaemia. The majority had normocytic normochromic anaemia with high serum ferritin levels. Vitamin D deficiency or insufficiency was 91.2% and electrolyte abnormalities were very common; 57.9% had hypocalcaemia, 61.4% had hyperphosphatemia and all patients had hyperkalaemia.

Conclusions: Muscle mass was preserved in most patients in this population, but the muscle power was significantly low, along with a high prevalence of hypoalbuminaemia, anaemia, vitamin D deficiency or insufficiency, hypocalcaemia, hyperphospatemia and hyperkalaemia.

背景与目的:维持血液透析患者的健康是一项具有挑战性的任务,有助于降低发病率和死亡率。斯里兰卡维持性血液透析人群中营养相关并发症的发生率尚不确定。本研究是一项基线研究,旨在确定维持性血液透析患者常见的营养相关并发症。方法:在斯里兰卡中部的一家三级保健中心对维持血液透析的成年患者进行了单中心横断面研究。采用简单随机抽样,评估患者的临床、人体测量、生物阻抗分析(BIA)体成分、实验室参数和肌力。结果:114例患者中,男性87例(76.3%),平均年龄52.6(±12.3)岁。样本人群中仅有9例(7.9%)患者体重过轻,77.2%的患者上臂中围(MUAC)正常,BIA分析中81.6%的患者肌肉质量百分比高,所有患者上臂中围(MAMC)正常。但根据EWGSOP2的建议,80.5%的患者握力低于肌肉减少症的临界值。低血清白蛋白患病率为33.3%,贫血发生率为60.5%。多数为正红细胞正色贫血伴高血清铁蛋白水平。维生素D缺乏或不足占91.2%,电解质异常非常常见;57.9%为低钙血症,61.4%为高磷血症,所有患者均为高钾血症。结论:该人群中大多数患者的肌肉质量得到了保留,但肌肉力量明显较低,同时低白蛋白血症、贫血、维生素D缺乏或不足、低钙血症、高磷血症和高钾血症的患病率较高。
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引用次数: 0
Trimester-specific thyroid hormone reference data in Sri Lankan women. 斯里兰卡妇女妊娠特异性甲状腺激素参考数据。
IF 0.4 Pub Date : 2022-06-30 DOI: 10.4038/cmj.v67i2.9629
Kamani Dhanushka Liyanarachchi, Dimuthu Tharanga Muthukuda, Udari Apsara Liyanage, Renuka Jayatissa, Lakma Tharindi Subasinghe, Ariyavidana Hareendra Pradeep, Eranga Colombage, Lalana Devi Ranasinghe, Nadun Prabuddha Liyanarachchi, Samantha Ranasinghe, Sarath Lekamwasam, Noel Somasundaram

Introduction: Regional differences in thyroid hormones are noted, especially during pregnancy.

Objectives: Establish reference values for thyroid function tests for Sri Lankan pregnant women and to determine their comparability with regional data; and determine the prevalence of 2. Thyroid Peroxidase (TPO) antibody positivity and 3. Iodine deficiency among pregnant women with uncomplicated clinical history.

Methods: A cross-sectional study conducted in antenatal clinics of a tertiary care maternity center recruited a minimum of 56 women in each trimester in a multistep approach to derive an "ideal-reference population"; Participants with clinically manifested thyroid disease, followed by subjects with sonographically abnormal thyroids and finally those at high risk for thyroid disease as shown by positive TPO levels and urine iodine deficiency were excluded in sequence. Thyroid hormones were measured by chemiluminescence in the ideal reference population. Reference ranges were derived using median and 5th and 95th centiles.

Results: Final sample included 369 women. TSH reference ranges of the first (n=64), second (n=188) and third (n=117) trimesters were 0.014-2.77mIU/L, 0.31-3.2 mIU/L and 0.34-3.4 mIU/L, respectively. TPO antibody level showed a weak but significant correlation with TSH (r=0.10,p 0.021) in the final sample. No significant association was found between urine iodine and thyroid function tests.

Conclusions: TSH reference ranges observed in this study are concordant with the Caucasian reference values more than the regional values. Discrepancies in study methodology, defining and selection of reference population and methods employed in measuring thyroid hormones in different studies may have accounted for these differences.

甲状腺激素的区域差异是值得注意的,特别是在怀孕期间。目的:为斯里兰卡孕妇建立甲状腺功能检查的参考值,并确定其与区域数据的可比性;并确定患病率2。甲状腺过氧化物酶(TPO)抗体阳性;无复杂临床史的孕妇碘缺乏。方法:在一家三级保健妇产中心的产前诊所进行的一项横断面研究,以多步骤方法在每个妊娠期招募至少56名妇女,以获得“理想参考人群”;有临床表现的甲状腺疾病受试者,其次是超声检查显示甲状腺异常的受试者,最后是TPO阳性和尿碘缺乏显示甲状腺疾病高风险的受试者。在理想参照人群中,用化学发光法测定甲状腺激素。参考范围采用中位数、第5百分位和第95百分位得出。结果:最终样本包括369名女性。妊娠第一(n=64)、第二(n=188)、第三(n=117)三个阶段的TSH参考范围分别为0.014 ~ 2.77mIU/L、0.31 ~ 3.2 mIU/L和0.34 ~ 3.4 mIU/L。在最终样本中,TPO抗体水平与TSH呈微弱但显著的相关性(r=0.10,p 0.021)。尿碘和甲状腺功能检查之间没有明显的联系。结论:本研究观察到的TSH参考值范围与高加索地区参考值的一致性大于区域参考值。不同研究中在研究方法学、参考人群的定义和选择以及测量甲状腺激素的方法上的差异可能是造成这些差异的原因。
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引用次数: 0
Physical Activity among Undergraduates in University of Peradeniya. 佩拉迪尼亚大学大学生体育活动状况研究
IF 0.4 Pub Date : 2022-06-30 DOI: 10.4038/cmj.v67i2.9635
Esther Liyanage, Ishendra Ridmi Fernando, Sumagi Isuru Seya Aththanayaka, Hashini Madhurangi Wijayasinghe, Nipuni Nimanthi Maheshika, Prarthana Sandakelum, Chathurika Lumbini Gunatilaka, Iresha Dilhari Senarath
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引用次数: 0
Kithul (Caryota urens) treacle: A healthy natural sweetener? 山核桃糖浆:健康的天然甜味剂?
IF 0.4 Pub Date : 2022-03-31 DOI: 10.4038/cmj.v67i1.9553
Pabasara Weeraratne, Sagarika Ekanayake

Introduction: Incidence of non communicable diseases such as diabetes, cardiovascular disease (CVD), several forms of cancer, hypertension, obesity etc is increasing in our country. It is suggested that these diseases can be moderated, in part, by consuming foods that produce a low blood sugar response. It is presumed that kithul treacle is comparable to simple sugars for sweetness, although currently the beneficial effects are not widely known.

Objectives: To assess the chemical composition and glycaemic indices (GI) of kithul treacle and confectionary (aluwa) made using table sugar and kithul treacle.

Methods: Chemical composition was analysed with standard AOAC methods. FAO/WHO guidelines were used to determine the glycaemic responses with glucose as the standard.

Results: The moisture, crude protein, crude fat, total carbohydrate, starch & glucose and total dietary fibre contents of treacle were 28%, 0.3%, 7.9%, 81%, 28% and 2.20% (DM) with negligible ash content. Similarly both aluwa had negligible ash contents. Total carbohydrate (88-89%), fat (2.9%), protein (3.7-4.2%) and total dietary fibre (7.78-8.32%) contents of both aluwa were not significantly different. However, the digestible carbohydrate contents of treacle (67%) and sugar aluwa (59%) were significantly different (p<0.05). The GI of kithul treacle, aluwa made with treacle and sugar were 35, 55 and 63 respectively.

Conclusion: Kithul treacle was categorized as a low GI food whereas both aluwa were categorized as medium GI foods. In comparison to aluwa made with table sugar, the glycaemic response of aluwa made with treacle was lower proving that replacing sugar with treacle leads to lower glycaemic response.

导读:我国非传染性疾病如糖尿病、心血管疾病、多种癌症、高血压、肥胖等的发病率正在上升。有人建议,这些疾病可以通过食用产生低血糖反应的食物来部分缓解。据推测,在甜度方面,薄荷糖浆与单糖相当,尽管目前对其有益的影响还不为人所知。目的:评价甜菜糖浆和蔗糖、甜菜糖浆制成的糖的化学成分和血糖指数。方法:采用标准AOAC法进行化学成分分析。采用粮农组织/世卫组织指南以葡萄糖为标准测定血糖反应。结果:糖浆的水分、粗蛋白质、粗脂肪、总碳水化合物、淀粉和葡萄糖、总膳食纤维含量分别为28%、0.3%、7.9%、81%、28%和2.20% (DM),灰分含量可忽略不计。同样,这两种矾石的灰分含量都可以忽略不计。总碳水化合物(88 ~ 89%)、脂肪(2.9%)、蛋白质(3.7 ~ 4.2%)和总膳食纤维(7.78 ~ 8.32%)含量差异不显著。然而,糖浆(67%)和白糖(59%)的可消化碳水化合物含量有显著差异(p结论:基图尔糖浆属于低GI食品,而白糖都属于中GI食品)。与蔗糖制作的aluwa相比,用糖蜜制作的aluwa的血糖反应较低,证明用糖蜜代替糖可以降低血糖反应。
{"title":"Kithul (Caryota urens) treacle: A healthy natural sweetener?","authors":"Pabasara Weeraratne,&nbsp;Sagarika Ekanayake","doi":"10.4038/cmj.v67i1.9553","DOIUrl":"https://doi.org/10.4038/cmj.v67i1.9553","url":null,"abstract":"<p><strong>Introduction: </strong>Incidence of non communicable diseases such as diabetes, cardiovascular disease (CVD), several forms of cancer, hypertension, obesity etc is increasing in our country. It is suggested that these diseases can be moderated, in part, by consuming foods that produce a low blood sugar response. It is presumed that kithul treacle is comparable to simple sugars for sweetness, although currently the beneficial effects are not widely known.</p><p><strong>Objectives: </strong>To assess the chemical composition and glycaemic indices (GI) of kithul treacle and confectionary (aluwa) made using table sugar and kithul treacle.</p><p><strong>Methods: </strong>Chemical composition was analysed with standard AOAC methods. FAO/WHO guidelines were used to determine the glycaemic responses with glucose as the standard.</p><p><strong>Results: </strong>The moisture, crude protein, crude fat, total carbohydrate, starch & glucose and total dietary fibre contents of treacle were 28%, 0.3%, 7.9%, 81%, 28% and 2.20% (DM) with negligible ash content. Similarly both aluwa had negligible ash contents. Total carbohydrate (88-89%), fat (2.9%), protein (3.7-4.2%) and total dietary fibre (7.78-8.32%) contents of both aluwa were not significantly different. However, the digestible carbohydrate contents of treacle (67%) and sugar aluwa (59%) were significantly different (p<0.05). The GI of kithul treacle, aluwa made with treacle and sugar were 35, 55 and 63 respectively.</p><p><strong>Conclusion: </strong>Kithul treacle was categorized as a low GI food whereas both aluwa were categorized as medium GI foods. In comparison to aluwa made with table sugar, the glycaemic response of aluwa made with treacle was lower proving that replacing sugar with treacle leads to lower glycaemic response.</p>","PeriodicalId":9777,"journal":{"name":"Ceylon Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10432895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Late-onset neurodegenerative manifestations in patients with cirrhosis: acquired hepatocerebral degeneration - a neglected diagnosis. 肝硬化患者的迟发性神经退行性表现:获得性肝脑变性——一个被忽视的诊断。
IF 0.4 Pub Date : 2022-03-31 DOI: 10.4038/cmj.v67i1.9557
Madunil Anuk Niriella, Abde Alibhoy, Hithanadura Janaka de Silva

Acquired hepatocerebral degeneration (AHCD) is an acquired, extrapyramidal, neurodegenerative condition, encountered in patients with cirrhosis. It is an uncommon and usually irreversible condition, resulting in widespread cerebral, basal ganglia and cerebellar damage. We describe here four cases of AHCD, with varying presentations, highlighting the need for increased awareness of this condition, to avoid diagnostics delays and unnecessary management.

获得性肝脑变性(AHCD)是一种获得性锥体外系神经退行性疾病,常见于肝硬化患者。这是一种罕见且通常不可逆的疾病,可导致广泛的大脑、基底神经节和小脑损伤。我们在这里描述了四个AHCD病例,有不同的表现,强调需要提高对这种情况的认识,以避免诊断延误和不必要的管理。
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引用次数: 0
Cannula segment pulmonary embolism. A rare complication of a fractured cannula. 导管段肺栓塞。套管断裂的罕见并发症。
IF 0.4 Pub Date : 2022-03-31 DOI: 10.4038/cmj.v67i1.9555
Joel Arudchelvam, Pirakash Pathmanesan, Ruwan Ranaweera
{"title":"Cannula segment pulmonary embolism. A rare complication of a fractured cannula.","authors":"Joel Arudchelvam,&nbsp;Pirakash Pathmanesan,&nbsp;Ruwan Ranaweera","doi":"10.4038/cmj.v67i1.9555","DOIUrl":"https://doi.org/10.4038/cmj.v67i1.9555","url":null,"abstract":"","PeriodicalId":9777,"journal":{"name":"Ceylon Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10077336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A report of haploidentical allogeneic haematopoietic stem cell transplantation for inherited bone marrow failure in Sri Lanka. 斯里兰卡单倍体同种异体造血干细胞移植治疗遗传性骨髓衰竭的报道。
IF 0.4 Pub Date : 2022-03-31 DOI: 10.4038/cmj.v67i1.9554
Wasanthi Wickramasinghe, Revathi Raj, Shama Goonatillake, Anuja Abayadeera, Malik Samarasinghe, Jeewaka Galhenage, Pavithra Aarewatte, Devan Mendis, Chandima Thevarapperuma, Ruwangi Dissanayake, Lallindra Gooneratne

Abstract: Bone marrow failure (BMF) in children can be idiopathic (70-80%) or inherited. Haematopoietic stem cell transplantation (HSCT) is the only cure for both causes. Allogeneic HSCT requires a suitable donor. Many children will not have a HLA matched sibling or unrelated donor. A haploidentical donor is available for all children as eaazch parent will have at minimum a 50% HLA match. This report of a 7-year old girl with BMF treated with a haplo-HSCT, the first in Sri Lanka, highlights the importance of developing a haploidentical HSCT programme as a potential cure for a disease with a dismal outcome.

摘要:儿童骨髓衰竭(BMF)可为特发性(70-80%)或遗传性。造血干细胞移植(HSCT)是治疗这两种疾病的唯一方法。同种异体造血干细胞移植需要合适的供体。许多孩子没有匹配的HLA的兄弟姐妹或无血缘关系的供体。所有的孩子都可以获得单倍体相同的供体,因为父母双方至少有50%的HLA匹配。这是斯里兰卡首例7岁BMF女孩接受单倍体造血干细胞移植治疗的报告,强调了开发单倍体造血干细胞移植计划作为治疗这种预后不佳的疾病的潜在方法的重要性。
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引用次数: 0
期刊
Ceylon Medical Journal
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