Chest最新文献

{"title":"Response.","authors":"Liang Zhou, Kaige Wang, Min Zhu, Fengming Luo","doi":"10.1016/j.chest.2025.08.029","DOIUrl":"https://doi.org/10.1016/j.chest.2025.08.029","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"169 1","pages":"e41-e42"},"PeriodicalIF":8.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent Class Analysis to Identify Subgroups in Clinical Research: A Data-Driven Approach.","authors":"Sébastien Bailly,Tanujit Dey","doi":"10.1016/j.chest.2025.07.4085","DOIUrl":"https://doi.org/10.1016/j.chest.2025.07.4085","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"29 1","pages":"37-40"},"PeriodicalIF":9.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Programming Childhood Lung Health: Critical Windows in Prenatal Environmental Exposure.","authors":"Luyu Xie,Timothy G Chow","doi":"10.1016/j.chest.2025.09.022","DOIUrl":"https://doi.org/10.1016/j.chest.2025.09.022","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"9 1","pages":"14-15"},"PeriodicalIF":9.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Holding an ACE: Rethinking Angiotensin-Converting Enzyme Inhibitors and Survival in Pulmonary Fibrosis.","authors":"Sabina A Guler","doi":"10.1016/j.chest.2025.10.012","DOIUrl":"https://doi.org/10.1016/j.chest.2025.10.012","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"21 1","pages":"6-8"},"PeriodicalIF":9.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POINT: Should Pulmonary and Critical Care Medicine Fellowship Training Programs Require Advanced Cardiac Point-of-Care Ultrasound Competency? Yes.","authors":"Timothy J Rowe,Mangala Narasimhan,Yonatan Y Greenstein","doi":"10.1016/j.chest.2025.07.4118","DOIUrl":"https://doi.org/10.1016/j.chest.2025.07.4118","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"28 1","pages":"26-28"},"PeriodicalIF":9.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Connection Between Respiratory Distress and Hypertension in an 18-Month-Old Girl.","authors":"Vibhu Agarwal,Palak Satija,Arpita Chattopadhyay,Diganta Saikia","doi":"10.1016/j.chest.2025.07.4086","DOIUrl":"https://doi.org/10.1016/j.chest.2025.07.4086","url":null,"abstract":"An 18-month-old girl presented to the emergency department with a 1-month history of fever, cough, and difficulty breathing. The cough was progressive over 1 month and productive in nature. Before this admission, she had been hospitalized for 21 days at another facility, where she required intubation and ventilation for 8 days and received IV antibiotics and nebulization for Pseudomonas aeruginosa pneumonia. The child was the firstborn of a nonconsanguineous marriage, with an unremarkable antenatal and natal history. Her developmental milestones were appropriate for her age, and she had completed age-appropriate immunizations without adverse reactions. Mother had history of 2 spontaneous abortions, both in the first trimester.","PeriodicalId":9782,"journal":{"name":"Chest","volume":"254 1","pages":"e5-e9"},"PeriodicalIF":9.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Statistical Significance: Clarifying Clinical Relevance of Dupilumab in COPD.","authors":"Parth Aphale,Shashank Dokania,Himanshu Shekhar","doi":"10.1016/j.chest.2025.08.032","DOIUrl":"https://doi.org/10.1016/j.chest.2025.08.032","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"386 1","pages":"e31"},"PeriodicalIF":9.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial Stenosis From Sarcoidosis-Associated Adenopathy and Fibrosing Mediastinitis Leading to Pulmonary Infarction.","authors":"Matthew Freedman,Ugochukwu Kingsley Odega,Allen Ko,Hannah Mannem,Catherine A Bonham","doi":"10.1016/j.chest.2025.06.047","DOIUrl":"https://doi.org/10.1016/j.chest.2025.06.047","url":null,"abstract":"Sarcoidosis is a systemic, granulomatous disorder commonly affecting the lungs that has the potential to cause numerous thoracic complications. We present a novel case of a 44-year-old woman with pulmonary sarcoidosis who demonstrated a large pulmonary infarction. The disease presentation ultimately was attributed to arterial stenosis resulting from sarcoidosis-associated fibrosing mediastinitis and compressive mediastinal adenopathy. The patient was treated with an extended course of prednisone and subsequently was transitioned to azathioprine with eventual resolution of symptoms, but persistence of imaging findings. Further treatment strategies were considered, including rituximab and vascular stenting, although not pursued. To our knowledge, this is the first reported case of pulmonary infarction caused by this mechanism, exemplifying the complex ways in which sarcoidosis can manifest.","PeriodicalId":9782,"journal":{"name":"Chest","volume":"46 1","pages":"e1-e4"},"PeriodicalIF":9.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Consistency of Hypercapnic Respiratory Failure Case Definitions in Electronic Health Record Data.","authors":"Brian W Locke, W Wayne Richards, Ramkiran Gouripeddi, Jeanette P Brown, Dustin Anderson-Bell, Joseph Finkelstein, Krishna M Sundar, Ithan D Peltan, Samuel M Brown","doi":"10.1016/j.chest.2025.08.002","DOIUrl":"10.1016/j.chest.2025.08.002","url":null,"abstract":"<p><strong>Background: </strong>Several studies suggest a high prevalence and disease burden associated with hypercapnic respiratory failure of any cause in emergency department (ED) and inpatient settings. However, these studies use different case definitions. The consistency and validity of these case definitions have not been assessed.</p><p><strong>Research questions: </strong>Do the various case definitions from health record-based studies of adults with hypercapnic respiratory failure identify the same, or similar, patients?</p><p><strong>Methods: </strong>We identified case definitions for hypercapnic respiratory failure from the peer-reviewed literature. We constructed an emulation data set enriched for the presence of hypercapnic respiratory failure from TriNetX (TriNetX, LLC), which aggregates health records from 76 hospitals in the United States. Adult ED and inpatient encounters occurring in 2022 were eligible for inclusion. We assessed consistency among case definitions by applying them to the emulation data set on the day of ED or hospital admission. We calculated Cohen's κ value and compared the patient characteristics and short-term outcomes for the cohorts defined by each case definition. We evaluated the accuracy of hypercapnic respiratory failure diagnosis codes for capturing hypercapnia demonstrated on first-day arterial blood gas samples.</p><p><strong>Results: </strong>Ten case definitions for hypercapnic respiratory failure were identified and were amenable to emulation. The emulation data set contained 515,286 encounters. Case definitions showed limited agreement (median κ = 0.35; interquartile range, 0.21-0.56) for hypercapnic respiratory failure identification. Key demographic characteristics, comorbidities, and outcomes such as receiving ventilatory support (range, 29%-100%) and 60-day mortality (range, 12%-28%) varied substantially among the resulting cohorts. Diagnosis codes were insensitive for capturing first-day arterial blood gas-demonstrated hypercapnia (sensitivity, 23.5%; 95% CI, 23.1%-23.8%).</p><p><strong>Interpretation: </strong>Case definitions from studies of hypercapnic respiratory failure identify patients with widely different attributes and outcomes, thereby hampering interpretation of associated study findings. Standardization of case definitions is necessary to improve the rigor and generalizability of research on hypercapnic respiratory failure.</p>","PeriodicalId":9782,"journal":{"name":"Chest","volume":" ","pages":"230-243"},"PeriodicalIF":8.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12739763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Global Participation in Interstitial Lung Disease Trials: A Work in Progress.","authors":"Deborah Assayag","doi":"10.1016/j.chest.2025.10.009","DOIUrl":"https://doi.org/10.1016/j.chest.2025.10.009","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"84 1","pages":"9-10"},"PeriodicalIF":9.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}