Pub Date : 2025-12-06DOI: 10.1016/j.chest.2025.10.047
Camille Taillé, Fatima Hamidi, Nicolas Heddebaut, Nicolas Poté, Pierre Le Guen, Mathilde Le Brun, Carine Roy, Axelle Dupont, Séverine Létuvé
{"title":"Impact of mepolizumab on airway remodeling and inflammation in severe eosinophilic asthma","authors":"Camille Taillé, Fatima Hamidi, Nicolas Heddebaut, Nicolas Poté, Pierre Le Guen, Mathilde Le Brun, Carine Roy, Axelle Dupont, Séverine Létuvé","doi":"10.1016/j.chest.2025.10.047","DOIUrl":"https://doi.org/10.1016/j.chest.2025.10.047","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"10 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145689548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-06DOI: 10.1016/j.chest.2025.11.033
Andrew W. Ormsby, Scott M. Matson, Melissa R. Griffith, M.Kristen Demoruelle, Joyce S. Lee
{"title":"Subclinical Interstitial Lung Disease in Rheumatoid Arthritis: Implications for Early Detection and Management","authors":"Andrew W. Ormsby, Scott M. Matson, Melissa R. Griffith, M.Kristen Demoruelle, Joyce S. Lee","doi":"10.1016/j.chest.2025.11.033","DOIUrl":"https://doi.org/10.1016/j.chest.2025.11.033","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"148 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145689550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Post-Lung Transplantation Care: The Case for Transplant Pulmonologist-Led Coordination.","authors":"Jens Gottlieb,Robin Vos,Berta Saez-Gimenez,Peter Jaksch","doi":"10.1016/j.chest.2025.06.053","DOIUrl":"https://doi.org/10.1016/j.chest.2025.06.053","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"8 1","pages":"e200-e202"},"PeriodicalIF":9.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.chest.2025.07.4073
Wen Sun
{"title":"Risk Factors and Future Directions for Pneumothorax Following Endobronchial Valve Implantation.","authors":"Wen Sun","doi":"10.1016/j.chest.2025.07.4073","DOIUrl":"https://doi.org/10.1016/j.chest.2025.07.4073","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"1 1","pages":"e196-e197"},"PeriodicalIF":9.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.chest.2025.07.4093
Zhilong Xu
{"title":"Reconsidering the Generalizability of Observation Strategies For Subsolid Pulmonary Nodules.","authors":"Zhilong Xu","doi":"10.1016/j.chest.2025.07.4093","DOIUrl":"https://doi.org/10.1016/j.chest.2025.07.4093","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"224 1","pages":"e206-e207"},"PeriodicalIF":9.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An 81-year-old woman was referred to our Cardiomyopathy Clinic for unexplained asymmetric left ventricular hypertrophy. She was asymptomatic, with no family history of cardiac disease nor of sudden cardiac death. The patient's medical history included a hepatitis C virus infection, successfully eradicated with antiviral therapy, and a hysterectomy for multiple uterine leiomyomas at the age of 36. Moreover, she underwent thoracoscopic right upper and right lower wedge resection for multiple pulmonary masses, consistent with metastatic benign leiomyomas, at the age of 63. Three years before the current evaluation, a recurrence of pulmonary leiomyomas, not affecting respiratory dynamics, nor causing any symptom, was diagnosed but not treated with surgery. Follow-up evaluations by CT scan showed slow progression of pulmonary lesions over the years in the absence of clinical manifestations.
{"title":"An Unexpected Cause of Asymmetric Left Ventricular Hypertrophy.","authors":"Matteo Beltrami,Matilde Papi,Iacopo Olivotto,Raffaella Santi,Gabriella Nesi,Maurizio Pieroni,Pierluigi Stefano","doi":"10.1016/j.chest.2025.06.035","DOIUrl":"https://doi.org/10.1016/j.chest.2025.06.035","url":null,"abstract":"An 81-year-old woman was referred to our Cardiomyopathy Clinic for unexplained asymmetric left ventricular hypertrophy. She was asymptomatic, with no family history of cardiac disease nor of sudden cardiac death. The patient's medical history included a hepatitis C virus infection, successfully eradicated with antiviral therapy, and a hysterectomy for multiple uterine leiomyomas at the age of 36. Moreover, she underwent thoracoscopic right upper and right lower wedge resection for multiple pulmonary masses, consistent with metastatic benign leiomyomas, at the age of 63. Three years before the current evaluation, a recurrence of pulmonary leiomyomas, not affecting respiratory dynamics, nor causing any symptom, was diagnosed but not treated with surgery. Follow-up evaluations by CT scan showed slow progression of pulmonary lesions over the years in the absence of clinical manifestations.","PeriodicalId":9782,"journal":{"name":"Chest","volume":"225 1","pages":"e171-e177"},"PeriodicalIF":9.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.chest.2025.07.4090
Xiang Le,Naijian Li,Yunxiang Zeng,Xinlu Wang,Jinlin Wang
An 18-year-old man with no prior medical history presented to the tertiary care center with a 6-month history of progressively worsening bone pain. The pain was localized to the right posterior ribs, mid-thoracic spine, and right iliac bone and was described as deep, throbbing, and exacerbated by physical activity, which significantly limited his mobility. Concurrently, he reported recurrent episodes of dyspnea and chest tightness, particularly in the supine position. Physical examination revealed reduced tactile fremitus and diminished breath sounds over the bilateral lower lung fields, with dullness to percussion. Bilateral pitting edema extended from the ankles to the knees (grade 1+), with no signs of joint swelling, skin rash, or lymphadenopathy. Vital signs were notable for low-grade fever (38.2 °C) and tachycardia (heart rate: 92 beats/min).
{"title":"Rare Case of Progressive Osteolysis and Chylothorax in an Adolescent Male.","authors":"Xiang Le,Naijian Li,Yunxiang Zeng,Xinlu Wang,Jinlin Wang","doi":"10.1016/j.chest.2025.07.4090","DOIUrl":"https://doi.org/10.1016/j.chest.2025.07.4090","url":null,"abstract":"An 18-year-old man with no prior medical history presented to the tertiary care center with a 6-month history of progressively worsening bone pain. The pain was localized to the right posterior ribs, mid-thoracic spine, and right iliac bone and was described as deep, throbbing, and exacerbated by physical activity, which significantly limited his mobility. Concurrently, he reported recurrent episodes of dyspnea and chest tightness, particularly in the supine position. Physical examination revealed reduced tactile fremitus and diminished breath sounds over the bilateral lower lung fields, with dullness to percussion. Bilateral pitting edema extended from the ankles to the knees (grade 1+), with no signs of joint swelling, skin rash, or lymphadenopathy. Vital signs were notable for low-grade fever (38.2 °C) and tachycardia (heart rate: 92 beats/min).","PeriodicalId":9782,"journal":{"name":"Chest","volume":"15 1","pages":"e187-e193"},"PeriodicalIF":9.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.chest.2025.08.009
Wytze S de Boer,W R Douma,T J Olgers,Y A de Reus
{"title":"A 63-Year-Old Man With a \"Clicking Sound\" in the Chest on Respiration.","authors":"Wytze S de Boer,W R Douma,T J Olgers,Y A de Reus","doi":"10.1016/j.chest.2025.08.009","DOIUrl":"https://doi.org/10.1016/j.chest.2025.08.009","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"8 1","pages":"e183-e185"},"PeriodicalIF":9.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-07-23DOI: 10.1016/j.chest.2025.06.050
Caroline K Tietbohl, Chloe Glaros, Kristen A Torres, Rafaela Avallone Mantelli, D Clark Files, Matthew F Mart, Michael A Matthay, Karen E A Burns, Daniel D Matlock, Matthew Wynia, Marc Moss
Background: Trust with researchers is a consideration among surrogate decision makers (SDMs) who are approached to provide consent for research participation on behalf of critically ill patients. However, little is known about strategies that researchers can use to build trust with SDMs and alleviate stress when making these decisions.
Research question: What are the best approaches to building trust and alleviating stress that can be used in the surrogate informed consent process?
Study design and methods: This convergent parallel mixed-methods study included surveys, focus groups, and semi-structured interviews with principal investigators (PIs), research coordinators (RCs), SDMs, and critically ill patients who were approached for participation in a critical care research clinical trial. Surveys captured opinions regarding trust and stress in the surrogate consent process, and qualitative findings described factors that influenced the trust and stress of the SDMs in this context.
Results: Overall, 230 individuals (90 PIs, 105 RCs, 27 SDMs, and 8 patients) completed surveys, and 61 (24 PIs, 23 RCs, 11 SDMs, and 3 patients) participated in focus groups/interviews. Three approaches were identified that participants described across data sources as significant for establishing trust and reducing stress among SDMs: (1) humanizing research participation; (2) tailoring approaches to patient/SDM background (eg, race, location, prior research experience); and (3) transparent communication about study details. Participants felt that researchers first needed to show that they were considering the patient as "a person," not as a study participant. Taking time to learn about and address aspects of the patient's or SDM's background was important, as was the manner in which study details were communicated. Although all participant groups largely agreed about the relevance of these factors, some differences between groups were noted.
Interpretation: Three strategies were identified that PIs, RCs, SDMs, and patients viewed as effective for building trust and alleviating stress in the surrogate informed consent process. Incorporating these approaches could enhance trust and participation in critical care research.
{"title":"Approaches for Establishing Trust and Alleviating Stress During the Surrogate Informed Consent Process for Critical Care Research.","authors":"Caroline K Tietbohl, Chloe Glaros, Kristen A Torres, Rafaela Avallone Mantelli, D Clark Files, Matthew F Mart, Michael A Matthay, Karen E A Burns, Daniel D Matlock, Matthew Wynia, Marc Moss","doi":"10.1016/j.chest.2025.06.050","DOIUrl":"10.1016/j.chest.2025.06.050","url":null,"abstract":"<p><strong>Background: </strong>Trust with researchers is a consideration among surrogate decision makers (SDMs) who are approached to provide consent for research participation on behalf of critically ill patients. However, little is known about strategies that researchers can use to build trust with SDMs and alleviate stress when making these decisions.</p><p><strong>Research question: </strong>What are the best approaches to building trust and alleviating stress that can be used in the surrogate informed consent process?</p><p><strong>Study design and methods: </strong>This convergent parallel mixed-methods study included surveys, focus groups, and semi-structured interviews with principal investigators (PIs), research coordinators (RCs), SDMs, and critically ill patients who were approached for participation in a critical care research clinical trial. Surveys captured opinions regarding trust and stress in the surrogate consent process, and qualitative findings described factors that influenced the trust and stress of the SDMs in this context.</p><p><strong>Results: </strong>Overall, 230 individuals (90 PIs, 105 RCs, 27 SDMs, and 8 patients) completed surveys, and 61 (24 PIs, 23 RCs, 11 SDMs, and 3 patients) participated in focus groups/interviews. Three approaches were identified that participants described across data sources as significant for establishing trust and reducing stress among SDMs: (1) humanizing research participation; (2) tailoring approaches to patient/SDM background (eg, race, location, prior research experience); and (3) transparent communication about study details. Participants felt that researchers first needed to show that they were considering the patient as \"a person,\" not as a study participant. Taking time to learn about and address aspects of the patient's or SDM's background was important, as was the manner in which study details were communicated. Although all participant groups largely agreed about the relevance of these factors, some differences between groups were noted.</p><p><strong>Interpretation: </strong>Three strategies were identified that PIs, RCs, SDMs, and patients viewed as effective for building trust and alleviating stress in the surrogate informed consent process. Incorporating these approaches could enhance trust and participation in critical care research.</p>","PeriodicalId":9782,"journal":{"name":"Chest","volume":" ","pages":"1364-1373"},"PeriodicalIF":8.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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