Pub Date : 2026-02-04DOI: 10.1016/j.chest.2025.12.052
Jasleen Minhas, Haochang Shou, Nadine Al-Naamani, Rui Feng, Roham Zamanian, Todd Bull, Murali Chakinala, Anna Hemnes, Jude Moutchia, Stephen C. Mathai, Susan Ellenberg, Corey Ventetuolo, Steven M. Kawut
{"title":"Daily Physical Activity in Pulmonary Arterial Hypertension: Insights from a Multicenter Longitudinal Trial Using Accelerometry","authors":"Jasleen Minhas, Haochang Shou, Nadine Al-Naamani, Rui Feng, Roham Zamanian, Todd Bull, Murali Chakinala, Anna Hemnes, Jude Moutchia, Stephen C. Mathai, Susan Ellenberg, Corey Ventetuolo, Steven M. Kawut","doi":"10.1016/j.chest.2025.12.052","DOIUrl":"https://doi.org/10.1016/j.chest.2025.12.052","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"399 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1016/j.chest.2026.01.016
Anthony J. Lo Piccolo:, Shane Antoinette Arante, Justin Chan, Kathryn Jano, Madeline A. DiLorenzo, Melissa Achenbaum, Regan Britt, David Butler, Radu Postelnicu, Erin McGuire, Vikramjit Mukherjee
{"title":"Outcomes of severe mpox admitted to intensive care units at two large New York City health systems, 2022-2024","authors":"Anthony J. Lo Piccolo:, Shane Antoinette Arante, Justin Chan, Kathryn Jano, Madeline A. DiLorenzo, Melissa Achenbaum, Regan Britt, David Butler, Radu Postelnicu, Erin McGuire, Vikramjit Mukherjee","doi":"10.1016/j.chest.2026.01.016","DOIUrl":"https://doi.org/10.1016/j.chest.2026.01.016","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"29 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1016/j.chest.2026.01.014
Alexander E. Jacobs, Derek R. Soled, Jonah Rubin
{"title":"Judgment Under Uncertainty: A Case-based Analysis of Cognitive Bias in ECMO Candidacy Decision-Making","authors":"Alexander E. Jacobs, Derek R. Soled, Jonah Rubin","doi":"10.1016/j.chest.2026.01.014","DOIUrl":"https://doi.org/10.1016/j.chest.2026.01.014","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"103 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-31DOI: 10.1016/j.chest.2025.12.049
Sebastian Riemann, Fleur L. Meulmeester, Samuel Mailhot-Larouche, Sanjay Ramakrishnan, Michael E. Wechsler, Jonathan Corren, Sarah E. Diver, Christopher E. Brightling, Mario Castro, Nicola A. Hanania, David J. Jackson, Neil Martin, Annette Laugerud, Deborah Clarke, Alison Moore, Megan E. Hardin, Cecile T.J. Holweg, Subhashini Allu, Timothy S.C. Hinks, Richard W. Beasley, Jacob K. Sont, Ewout W. Steyerberg, Ian D. Pavord, Guy Brusselle, Simon Couillard
{"title":"Sex does not modify prediction of asthma attacks by clinical risk factors and Type-2 biomarkers","authors":"Sebastian Riemann, Fleur L. Meulmeester, Samuel Mailhot-Larouche, Sanjay Ramakrishnan, Michael E. Wechsler, Jonathan Corren, Sarah E. Diver, Christopher E. Brightling, Mario Castro, Nicola A. Hanania, David J. Jackson, Neil Martin, Annette Laugerud, Deborah Clarke, Alison Moore, Megan E. Hardin, Cecile T.J. Holweg, Subhashini Allu, Timothy S.C. Hinks, Richard W. Beasley, Jacob K. Sont, Ewout W. Steyerberg, Ian D. Pavord, Guy Brusselle, Simon Couillard","doi":"10.1016/j.chest.2025.12.049","DOIUrl":"https://doi.org/10.1016/j.chest.2025.12.049","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"282 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146089569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-29DOI: 10.1016/j.chest.2025.12.048
Quinlan Richert, Nicholas Miller, Shane Cameron, Bryce Barr, Joel Nkosi, Aditya Sharma
{"title":"UPDATES ON RHABDOMYOLYSIS: A CLINICALLY-ORIENTED NARRATIVE REVIEW","authors":"Quinlan Richert, Nicholas Miller, Shane Cameron, Bryce Barr, Joel Nkosi, Aditya Sharma","doi":"10.1016/j.chest.2025.12.048","DOIUrl":"https://doi.org/10.1016/j.chest.2025.12.048","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"3 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146072253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1016/j.chest.2025.12.047
Abhimanyu Chandel MD, Simon Turkington MD, Christopher S. King MD, Anju Singhal MD, Alan Nyquist MD, A.Whitney Brown MD, Steven D. Nathan MD
Pulmonary hypertension (PH) is a complication of advanced cystic fibrosis (CF) and non-cystic fibrosis bronchiectasis (n-CFB). The prevalence and post-transplantation prognostic significance of PH in CF and n-CFB remains poorly defined.
{"title":"Pulmonary hypertension prevalence and significance in lung transplant recipients with cystic fibrosis and non-cystic fibrosis bronchiectasis","authors":"Abhimanyu Chandel MD, Simon Turkington MD, Christopher S. King MD, Anju Singhal MD, Alan Nyquist MD, A.Whitney Brown MD, Steven D. Nathan MD","doi":"10.1016/j.chest.2025.12.047","DOIUrl":"https://doi.org/10.1016/j.chest.2025.12.047","url":null,"abstract":"Pulmonary hypertension (PH) is a complication of advanced cystic fibrosis (CF) and non-cystic fibrosis bronchiectasis (n-CFB). The prevalence and post-transplantation prognostic significance of PH in CF and n-CFB remains poorly defined.","PeriodicalId":9782,"journal":{"name":"Chest","volume":"33 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146056087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-24DOI: 10.1016/j.chest.2026.01.009
Chandra Prakash Yadav, Laura Huey Mien Lim, David Price, Rupsa Roy, Juang Yah Ru, Richard Beasley, Christer Janson, Mariko Siyue Koh, Eileen Wang, Michael E. Wechsler, David J. Jackson, John Busby, Liam G. Heaney, Paul E. Pfeffer, Bassam Mahboub, Diahn-Warng Perng Steve, Borja G. Cosio, Luis Perez-de-Llano, Riyad Al-Lehebi, Désirée Larenas-Linnemann, Mona Al-Ahmad, Chin Kook Rhee, Takashi Iwanaga, Enrico Heffler, Giorgio Walter Canonica, Richard Costello, Nikolaos G. Papadopoulos, Andriana I. Papaioannou, Celeste M. Porsbjerg, Carlos A. Torres-Duque, George C. Christoff, Todor A. Popov, Mark Hew, Matthew Peters, Peter G. Gibson, Jorge Maspero, Celine Bergeron, Saraid Cerda, Elvia Angelica Contreras, Wenjia Chen
{"title":"Interactive Pathways of Key Prognostic Factors in Severe Asthma: A Bayesian Network Comparison of Clinical Trials & Real-World Data","authors":"Chandra Prakash Yadav, Laura Huey Mien Lim, David Price, Rupsa Roy, Juang Yah Ru, Richard Beasley, Christer Janson, Mariko Siyue Koh, Eileen Wang, Michael E. Wechsler, David J. Jackson, John Busby, Liam G. Heaney, Paul E. Pfeffer, Bassam Mahboub, Diahn-Warng Perng Steve, Borja G. Cosio, Luis Perez-de-Llano, Riyad Al-Lehebi, Désirée Larenas-Linnemann, Mona Al-Ahmad, Chin Kook Rhee, Takashi Iwanaga, Enrico Heffler, Giorgio Walter Canonica, Richard Costello, Nikolaos G. Papadopoulos, Andriana I. Papaioannou, Celeste M. Porsbjerg, Carlos A. Torres-Duque, George C. Christoff, Todor A. Popov, Mark Hew, Matthew Peters, Peter G. Gibson, Jorge Maspero, Celine Bergeron, Saraid Cerda, Elvia Angelica Contreras, Wenjia Chen","doi":"10.1016/j.chest.2026.01.009","DOIUrl":"https://doi.org/10.1016/j.chest.2026.01.009","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"143 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-24DOI: 10.1016/j.chest.2026.01.008
Erika D. Penz, Ada Ip-Buting, Willis H. Tsai, Maria J. Santana, W.Ward Flemons, Kristin L. Fraser, Sachin R. Pendharkar
{"title":"Twelve-month follow-up and economic evaluation of an alternative care provider clinic for severe sleep-disordered breathing","authors":"Erika D. Penz, Ada Ip-Buting, Willis H. Tsai, Maria J. Santana, W.Ward Flemons, Kristin L. Fraser, Sachin R. Pendharkar","doi":"10.1016/j.chest.2026.01.008","DOIUrl":"https://doi.org/10.1016/j.chest.2026.01.008","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"85 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1016/j.chest.2026.01.006
Adoma Manful, Nikita Amanna, S.Lani Park, Jessica L. Petrick, Lynn Rosenberg, Hilary Tindle, Julie Palmer, Lynne Wilkens, Loïc Le Marchand, Melinda C. Aldrich, Jeffrey D. Blume
{"title":"THE IMPACT OF THE 2023 ACS SCREENING RECOMMENDATIONS ON RACIAL, ETHNIC, AND SEX DISPARITIES IN LUNG CANCER SCREENING ELIGIBILITY","authors":"Adoma Manful, Nikita Amanna, S.Lani Park, Jessica L. Petrick, Lynn Rosenberg, Hilary Tindle, Julie Palmer, Lynne Wilkens, Loïc Le Marchand, Melinda C. Aldrich, Jeffrey D. Blume","doi":"10.1016/j.chest.2026.01.006","DOIUrl":"https://doi.org/10.1016/j.chest.2026.01.006","url":null,"abstract":"","PeriodicalId":9782,"journal":{"name":"Chest","volume":"28 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-16DOI: 10.1016/j.chest.2026.01.002
Valerie Dehondt,Frauke Van Vaerenbergh,Katia Verhamme,Lies Lahousse
BACKGROUNDPrevious studies have shown inconsistent results regarding the use of proton pump inhibitor (PPIs) and the risk on exacerbations in patients with chronic obstructive airway diseases.RESEARCH QUESTIONIs chronic PPI use associated with exacerbation risk?METHODSUsing Belgian nationwide claims-based data of adult patients on chronic medication for obstructive airway diseases (COAD) between 2017 and 2022, we investigated the association between PPI use and exacerbation risk using multivariable Cox models. Based on defined daily doses (DDDs) dispensed during the prior year, dose-dependent associations were assessed by inverse probability of treatment weighted (IPTW) Cox regression models.RESULTSAmong 932,135 included COAD patients, 416,087 (44.6%) were PPI-users, of whom 57,540 (13.8%) had 1-28 DDDs of PPIs, 128,017 (30.8%) 29-180 DDDs, 127,981 (30.8%) 181-365 DDDs, and 102,549 (24.6%) >365 DDDs in the previous year. Beyond age, sex, smoking, socio-economic status, exacerbation history, short-acting bronchodilator use, frailty and comorbidities, PPI use was associated with an increased risk of exacerbations (aHR 1.18, 95%CI 1.17-1.19). Moreover, compared to non-users, the risk of exacerbations increased with cumulative DDD (HR≤28DDDs 1.09, 95%CI 1.07-1.10; HR≤180DDDs 1.15, 95%CI 1.14-1.16; HR≤365DDDs 1.19, 95%CI 1.18-1.20; and HR>365DDDs 1.24, 95%CI 1.23-1.26). Sensitivity analyses indicated that the association with exacerbation risk was most pronounced in patients without gastroesophageal reflux disease (GERD), with asthma, under 50 years, non-frail patients, and those with increased PPI plasma concentrations.CONCLUSIONCumulative PPI use in patients with obstructive lung diseases was associated with an increase in exacerbation risk. This highlights to carefully consider PPI use in clinical respiratory practice.
{"title":"Exacerbation Risk by Chronic Proton Pump Inhibitor use in Obstructive Lung Diseases.","authors":"Valerie Dehondt,Frauke Van Vaerenbergh,Katia Verhamme,Lies Lahousse","doi":"10.1016/j.chest.2026.01.002","DOIUrl":"https://doi.org/10.1016/j.chest.2026.01.002","url":null,"abstract":"BACKGROUNDPrevious studies have shown inconsistent results regarding the use of proton pump inhibitor (PPIs) and the risk on exacerbations in patients with chronic obstructive airway diseases.RESEARCH QUESTIONIs chronic PPI use associated with exacerbation risk?METHODSUsing Belgian nationwide claims-based data of adult patients on chronic medication for obstructive airway diseases (COAD) between 2017 and 2022, we investigated the association between PPI use and exacerbation risk using multivariable Cox models. Based on defined daily doses (DDDs) dispensed during the prior year, dose-dependent associations were assessed by inverse probability of treatment weighted (IPTW) Cox regression models.RESULTSAmong 932,135 included COAD patients, 416,087 (44.6%) were PPI-users, of whom 57,540 (13.8%) had 1-28 DDDs of PPIs, 128,017 (30.8%) 29-180 DDDs, 127,981 (30.8%) 181-365 DDDs, and 102,549 (24.6%) >365 DDDs in the previous year. Beyond age, sex, smoking, socio-economic status, exacerbation history, short-acting bronchodilator use, frailty and comorbidities, PPI use was associated with an increased risk of exacerbations (aHR 1.18, 95%CI 1.17-1.19). Moreover, compared to non-users, the risk of exacerbations increased with cumulative DDD (HR≤28DDDs 1.09, 95%CI 1.07-1.10; HR≤180DDDs 1.15, 95%CI 1.14-1.16; HR≤365DDDs 1.19, 95%CI 1.18-1.20; and HR>365DDDs 1.24, 95%CI 1.23-1.26). Sensitivity analyses indicated that the association with exacerbation risk was most pronounced in patients without gastroesophageal reflux disease (GERD), with asthma, under 50 years, non-frail patients, and those with increased PPI plasma concentrations.CONCLUSIONCumulative PPI use in patients with obstructive lung diseases was associated with an increase in exacerbation risk. This highlights to carefully consider PPI use in clinical respiratory practice.","PeriodicalId":9782,"journal":{"name":"Chest","volume":"42 1","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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