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Conditioning and pseudoconditioning differently change intrinsic excitability of inhibitory interneurons in the neocortex 条件反射和假条件反射对神经皮层抑制性中间神经元内在兴奋性的改变不同
Pub Date : 2024-04-01 DOI: 10.1093/cercor/bhae109
D. Kanigowski, Joanna Urban-Ciecko
Abstract Many studies indicate a broad role of various classes of GABAergic interneurons in the processes related to learning. However, little is known about how the learning process affects intrinsic excitability of specific classes of interneurons in the neocortex. To determine this, we employed a simple model of conditional learning in mice where vibrissae stimulation was used as a conditioned stimulus and a tail shock as an unconditioned one. In vitro whole-cell patch-clamp recordings showed an increase in intrinsic excitability of low-threshold spiking somatostatin-expressing interneurons (SST-INs) in layer 4 (L4) of the somatosensory (barrel) cortex after the conditioning paradigm. In contrast, pseudoconditioning reduced intrinsic excitability of SST-LTS, parvalbumin-expressing interneurons (PV-INs), and vasoactive intestinal polypeptide-expressing interneurons (VIP-INs) with accommodating pattern in L4 of the barrel cortex. In general, increased intrinsic excitability was accompanied by narrowing of action potentials (APs), whereas decreased intrinsic excitability coincided with AP broadening. Altogether, these results show that both conditioning and pseudoconditioning lead to plastic changes in intrinsic excitability of GABAergic interneurons in a cell-specific manner. In this way, changes in intrinsic excitability can be perceived as a common mechanism of learning-induced plasticity in the GABAergic system.
摘要 许多研究表明,各类 GABA 能中间神经元在与学习有关的过程中发挥着广泛的作用。然而,人们对学习过程如何影响新皮层中特定类别中间神经元的内在兴奋性知之甚少。为了确定这一点,我们采用了一个简单的小鼠条件学习模型,将振动刺激作为条件刺激,将尾部冲击作为非条件刺激。体外全细胞贴片钳记录显示,在条件范式之后,躯体感觉(桶状)皮层第 4 层(L4)的低阈值尖峰表达体生长抑素的中间神经元(SST-INs)的内在兴奋性增加。与此相反,假条件反射降低了桶状皮层 L4 中具有容纳模式的 SST-LTS、副发光素表达中间神经元(PV-INs)和血管活性肠道多肽表达中间神经元(VIP-INs)的内在兴奋性。一般来说,固有兴奋性的增加伴随着动作电位(AP)的变窄,而固有兴奋性的降低则伴随着动作电位的变宽。总之,这些结果表明,调理和假调理都会以细胞特异性的方式导致 GABA 能中间神经元固有兴奋性的可塑性变化。因此,内在兴奋性的变化可被视为GABA能系统学习诱导可塑性的共同机制。
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引用次数: 0
Phonological properties of logographic words modulate brain activation in bilinguals: a comparative study of Chinese characters and Japanese Kanji 逻辑词的语音特性调节双语者的大脑激活:汉字与日语汉字的比较研究
Pub Date : 2024-04-01 DOI: 10.1093/cercor/bhae150
Zhenglong Lin, Xiujun Li, Geqi Qi, Jiajia Yang, Hongzan Sun, Qiyong Guo, Jinglong Wu, Min Xu
Abstract The brain networks for the first (L1) and second (L2) languages are dynamically formed in the bilingual brain. This study delves into the neural mechanisms associated with logographic–logographic bilingualism, where both languages employ visually complex and conceptually rich logographic scripts. Using functional Magnetic Resonance Imaging, we examined the brain activity of Chinese–Japanese bilinguals and Japanese–Chinese bilinguals as they engaged in rhyming tasks with Chinese characters and Japanese Kanji. Results showed that Japanese–Chinese bilinguals processed both languages using common brain areas, demonstrating an assimilation pattern, whereas Chinese–Japanese bilinguals recruited additional neural regions in the left lateral prefrontal cortex for processing Japanese Kanji, reflecting their accommodation to the higher phonological complexity of L2. In addition, Japanese speakers relied more on the phonological processing route, while Chinese speakers favored visual form analysis for both languages, indicating differing neural strategy preferences between the 2 bilingual groups. Moreover, multivariate pattern analysis demonstrated that, despite the considerable neural overlap, each bilingual group formed distinguishable neural representations for each language. These findings highlight the brain’s capacity for neural adaptability and specificity when processing complex logographic languages, enriching our understanding of the neural underpinnings supporting bilingual language processing.
摘要 第一语言(L1)和第二语言(L2)的大脑网络是在双语大脑中动态形成的。本研究探讨了逻各斯-逻各斯双语(两种语言都使用视觉复杂、概念丰富的逻各斯脚本)的相关神经机制。我们利用功能磁共振成像技术,研究了中日双语者和日中双语者在进行汉字和日语汉字押韵任务时的大脑活动。结果表明,日汉双语者使用共同的脑区处理两种语言,表现出一种同化模式,而中日双语者在处理日语汉字时,在左外侧前额叶皮层招募了额外的神经区域,这反映了他们对第二语言更高的语音复杂性的适应。此外,日语双语者更依赖于语音处理途径,而汉语双语者则更倾向于视觉形式分析,这表明这两个双语组之间存在不同的神经策略偏好。此外,多变量模式分析表明,尽管神经系统有相当大的重叠,但每个双语组都对每种语言形成了可区分的神经表征。这些发现凸显了大脑在处理复杂逻辑语言时的神经适应能力和特异性,丰富了我们对支持双语语言处理的神经基础的理解。
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引用次数: 0
Inferior parietal cortex represents relational structures for explicit transitive inference 下顶叶皮层代表关系结构,用于显式传递推理
Pub Date : 2024-04-01 DOI: 10.1093/cercor/bhae137
Biman Xu, Jing Wu, Haoyun Xiao, Thomas F Münte, Zheng Ye
Abstract The human brain is distinguished by its ability to perform explicit logical reasoning like transitive inference. This study investigated the functional role of the inferior parietal cortex in transitive inference with functional MRI. Participants viewed premises describing abstract relations among items. They accurately recalled the relationship between old pairs of items, effectively inferred the relationship between new pairs of items, and discriminated between true and false relationships for new pairs. First, the inferior parietal cortex, but not the hippocampus or lateral prefrontal cortex, was associated with transitive inference. The inferior parietal activity and functional connectivity were modulated by inference (new versus old pairs) and discrimination (true versus false pairs). Moreover, the new/old and true/false pairs were decodable from the inferior parietal representation. Second, the inferior parietal cortex represented an integrated relational structure (ordered and directed series). The inferior parietal activity was modulated by serial position (larger end versus center pairs). The inferior parietal representation was modulated by symbolic distance (adjacent versus distant pairs) and direction (preceding versus following pairs). It suggests that the inferior parietal cortex may flexibly integrate observed relations into a relational structure and use the relational structure to infer unobserved relations and discriminate between true and false relations.
摘要 人脑的特点是能够进行明确的逻辑推理,如反证推理。本研究通过功能性核磁共振成像研究了下顶叶皮层在传递推理中的功能作用。参与者观看了描述物品间抽象关系的前提。他们准确地回忆起了旧的物品对之间的关系,有效地推断出了新的物品对之间的关系,并区分了新的物品对之间的真假关系。首先,下顶叶皮层而非海马或外侧前额叶皮层与反式推理有关。下顶叶的活动和功能连接受推理(新对与旧对)和辨别(真对与假对)的调节。此外,新/旧对和真/假对可以通过下顶叶表征进行解码。其次,下顶叶皮层代表一种综合的关系结构(有序和有方向的序列)。下顶叶的活动受序列位置的调节(末端与中心成对)。下顶叶表征受符号距离(相邻与相距较远的数对)和方向(前面与后面的数对)的调节。这表明下顶叶皮层可以灵活地将观察到的关系整合到关系结构中,并利用关系结构来推断未观察到的关系和区分真假关系。
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引用次数: 1
Consistently increased dorsolateral prefrontal cortex activity during the exposure to acute stressors 在急性应激事件中,前额叶皮层背外侧的活动持续增加
Pub Date : 2024-04-01 DOI: 10.1093/cercor/bhae159
J. Meier, Lars Schwabe
Abstract Stress has a major impact on our mental health. Nonetheless, it is still not fully understood how the human brain responds to ongoing stressful events. Here, we aimed to determine the cortical dynamics during the exposure to ecologically valid, standardized stressors. To this end, we conducted 3 experiments in which healthy participants underwent the Trier Social Stress Test (experiments 1 and 2) and the Socially Evaluated Cold Pressor Test (experiment 3) or a respective control manipulation, while we measured their cortical activity using functional near-infrared spectroscopy. Increases in salivary cortisol and subjective stress levels confirmed the successful stress induction in all experiments. Results of experiment 1 showed significantly increased cortical activity, in particular in the dorsolateral prefrontal cortex, during the exposure to the Trier Social Stress Test. Experiment 2 replicated this finding and showed further that this stress-related increase in dorsolateral prefrontal cortex activity was transient and limited to the period of the Trier Social Stress Test. Experiment 3 demonstrated the increased dorsolateral prefrontal cortex activity during the Socially Evaluated Cold Pressor Test, suggesting that this increase is generalizable and not specific to the Trier Social Stress Test. Together, these data show consistently that dorsolateral prefrontal cortex activity is not reduced, as commonly assumed, but increased under stress, which may promote coping with the ongoing stressor.
摘要 压力对我们的心理健康有重大影响。然而,人们对人脑如何应对持续的压力事件仍不甚了解。在此,我们旨在确定大脑皮层在暴露于生态有效的标准化压力源时的动态变化。为此,我们进行了 3 项实验,让健康参与者接受特里尔社会压力测试(实验 1 和 2)和社会评价冷压力测试(实验 3)或相应的对照操作,同时使用功能性近红外光谱测量他们的大脑皮层活动。唾液皮质醇和主观压力水平的增加证实了所有实验都成功地诱导了压力。实验 1 的结果显示,在接受特里尔社会压力测试时,大脑皮层活动明显增加,尤其是背外侧前额叶皮层。实验 2 复制了这一结果,并进一步表明与压力相关的背外侧前额叶皮层活动增加是短暂的,且仅限于特里尔社交压力测试期间。实验 3 显示,在社会评价冷压力测试期间,背外侧前额叶皮层活动增加,这表明这种增加具有普遍性,而不是特里尔社会压力测试所特有的。总之,这些数据一致表明,前额叶皮层背外侧的活动并没有像通常认为的那样减少,而是在压力下增加了,这可能会促进对持续压力的应对。
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引用次数: 0
In vivo ephaptic coupling allows memory network formation 体内触觉耦合允许记忆网络的形成
Pub Date : 2023-06-20 DOI: 10.1101/2023.02.28.530474
D. Pinotsis, E. Miller
It is increasingly clear that memories are distributed across multiple brain areas. Such “engram complexes” are important features of memory formation and consolidation. Here, we test the hypothesis that engram complexes are formed in part by bioelectric fields that sculpt and guide the neural activity and tie together the areas that participate in engram complexes. Like the conductor of an orchestra, the fields influence each musician or neuron and orchestrate the output, the symphony. Our results use the theory of synergetics, machine learning and data from a spatial delayed saccade task and provide evidence for in vivo ephaptic coupling in memory representations.
越来越清楚的是,记忆分布在大脑的多个区域。这种“印痕复合体”是记忆形成和巩固的重要特征。在这里,我们测试了一个假设,即印迹复合物部分是由生物电场形成的,生物电场塑造和引导神经活动,并将参与印迹复合物的区域联系在一起。就像管弦乐队的指挥一样,磁场影响着每个音乐家或神经元,并编排出交响乐的输出。我们的研究结果使用了协同理论、机器学习和来自空间延迟扫视任务的数据,并为记忆表征中的体内触觉耦合提供了证据。
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引用次数: 9
3D synaptic organization of layer III of the human anterior cingulate and temporopolar cortex 人类前扣带皮层和颞极皮层第三层的三维突触组织
Pub Date : 2023-02-22 DOI: 10.1101/2023.02.21.529433
N. Cano-Astorga, S. Plaza-Alonso, J. DeFelipe, L. Alonso-Nanclares
The human anterior cingulate and temporopolar cortices have been proposed as highly connected nodes involved in high-order cognitive functions, but their synaptic organization is still basically unknown due to the difficulties involved in studying the human brain. Using Focused Ion Beam/Scanning Electron Microscopy (FIB/SEM) to study the synaptic organization of the human brain obtained with a short post-mortem delay allows excellent results to be obtained. We have used this technology to analyze the neuropil (where the vast majority of synapses are found) of layer III of the anterior cingulate cortex (Brodmann’s area 24) and the temporopolar cortex, including the temporal pole (Brodmann’s area 38 ventral and dorsal) and anterior middle temporal gyrus (Brodmann’s area 21). Our results, based on 6695 synapses fully reconstructed in 3D, revealed that Brodmann’s areas 24, 21 and ventral area 38 showed similar synaptic density and synaptic size, whereas dorsal area 38 displayed the highest synaptic density and the smallest synaptic size. However, the proportion of the different types of synapses (excitatory and inhibitory), the postsynaptic targets and the shapes of excitatory and inhibitory synapses were similar, regardless of the region examined. These observations indicate that certain aspects of the synaptic organization are rather homogeneous, whereas others show specific variations across cortical regions. Since not all data obtained in a given cortical region can be extrapolated to other cortical regions, further studies on the other cortical regions and layers are necessary to better understand the functional organization of the human cerebral cortex.
人类前扣带皮层和颞极皮层被认为是参与高阶认知功能的高度连接的节点,但由于研究人脑的困难,它们的突触组织仍然基本未知。使用聚焦离子束/扫描电子显微镜(FIB/SEM)来研究人类大脑的突触组织,在短时间的死后延迟可以获得很好的结果。我们使用该技术分析了前扣带皮层第三层(Brodmann’s area 24)和颞极皮层,包括颞极(Brodmann’s area 38腹侧和背侧)和前颞中回(Brodmann’s area 21)的神经层(发现绝大多数突触的地方)。基于6695个完全三维重建的突触,我们的研究结果显示,Brodmann区24、21和腹侧区38具有相似的突触密度和突触大小,而背侧区38具有最高的突触密度和最小的突触大小。然而,不同类型的突触(兴奋性和抑制性)的比例,突触后目标和兴奋性和抑制性突触的形状是相似的,无论检查的区域。这些观察结果表明,突触组织的某些方面是相当均匀的,而其他方面则显示出皮层区域之间的特定差异。由于并非在某一皮层区域获得的所有数据都可以外推到其他皮层区域,因此有必要对其他皮层区域和皮层层进行进一步研究,以更好地了解人类大脑皮层的功能组织。
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引用次数: 0
A middle ground where executive control meets semantics: the neural substrates of semantic control are topographically sandwiched between the multiple-demand and default-mode systems 执行控制满足语义的中间地带:语义控制的神经基质在地形上夹在多需求和默认模式系统之间
Pub Date : 2022-08-16 DOI: 10.1101/2021.11.26.470178
R. Chiou, E. Jefferies, J. Duncan, Gina F. Humphreys, M. L. Lambon Ralph
Semantic control is the capability to operate on meaningful representations, selectively focusing on certain aspects of meaning while purposefully ignoring other aspects based on one’s behavioural aim. This ability is especially vital for comprehending figurative/ambiguous language. It remains unclear, at the topographical level, why/how regions involved in semantic control seem reliably juxtaposed alongside other functionally specialised regions in the association cortex. We investigated this issue by characterising how semantic control regions topographically relate to the default-mode network (associated with memory and abstract cognition) and multiple-demand network (associated with executive control). Topographically, we confirmed that semantic control areas were sandwiched by the default-mode and multi-demand networks, forming an orderly arrangement observed both at the individual- and group-level. Functionally, semantic control regions exhibited ‘hybrid’ responses, fusing a preference for cognitively demanding processing (multiple-demand) and a preference for meaningful representations (default-mode) into a domain-specific preference for difficult operations on meaningful representations. When projected onto the principal gradient of human connectome, the neural activity of semantic control showed a robustly dissociable trajectory from visuospatial control, implying different roles in the functional transition from sensation to cognition. We discuss why the hybrid functional profile of semantic control regions might result from their intermediate topographical positions.
语义控制是对有意义的表征进行操作的能力,有选择地关注意义的某些方面,而基于一个人的行为目标有目的地忽略其他方面。这种能力对于理解比喻性或模棱两可的语言尤为重要。目前尚不清楚,在地形水平上,为什么/如何参与语义控制的区域似乎可靠地与联想皮层中其他功能专门化的区域并列。我们通过描述语义控制区域在地形上如何与默认模式网络(与记忆和抽象认知相关)和多需求网络(与执行控制相关)相关来研究这个问题。在地形上,我们证实了语义控制区域被默认模式和多需求网络夹在中间,形成了一个在个人和群体层面都能观察到的有序安排。在功能上,语义控制区域表现出“混合”反应,将对认知要求处理的偏好(多需求)和对有意义表征的偏好(默认模式)融合为对有意义表征的困难操作的特定领域偏好。当投射到人类连接组的主梯度上时,语义控制的神经活动与视觉空间控制的神经活动表现出明显的可分离轨迹,这意味着从感觉到认知的功能转变中存在不同的作用。我们讨论了为什么语义控制区域的混合功能轮廓可能是由它们的中间地形位置造成的。
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引用次数: 10
Correction to: Individual resting-state alpha peak frequency and within-trial changes in alpha peak frequency both predict visual dual-pulse segregation performance 校正:个体静息状态α峰频率和试验内α峰频率的变化都预测了视觉双脉冲分离性能
Pub Date : 2022-05-16 DOI: 10.1093/cercor/bhac200
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引用次数: 1
Correction to: Irreversible specialization for speech perception in early international adoptees 修正:早期国际收养者言语感知的不可逆专业化
Pub Date : 2022-04-25 DOI: 10.1093/cercor/bhac181
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引用次数: 0
Correction to: Brain knows who is on the same wavelength: resting-state connectivity can predict compatibility of a female–male relationship 更正:大脑知道谁是同一波长的人:静息状态连接可以预测男女关系的兼容性
Pub Date : 2022-03-30 DOI: 10.1093/cercor/bhac142
S. Kajimura, A. Ito, Keise Izuma
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Cerebral Cortex, 2022;32: 2057–2060
这是一篇基于知识共享署名非商业许可协议(http://creativecommons.org/ licenses/by-nc/4.0/)的开放获取文章,该协议允许在任何媒介上进行非商业再利用、分发和复制,前提是正确引用原创作品。商业再利用,请联系journals.permissions@oup.com大脑皮层,2022;32:2057-2060
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引用次数: 2
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Cerebral Cortex (New York, NY)
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