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Characterization of Polysaccharides Derived From Cinnamomum cassia and Their Potential of Antioxidant Activity and Protective Action Against Methomyl Induced Rats Damage With In Silico Docking 桂皮多糖的表征及其对灭多威大鼠硅对接损伤的抗氧化和保护作用。
IF 2.5 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2026-01-21 DOI: 10.1002/cbdv.202503347
Nozza Bouzenna, Mabrouk Horchani, Sabah Dhibi, Hafsia Bouzenna, Fatma Guesmi, Anouar Feriani, Hichem Ben Jannet, Sirine Choura, Angelo Maria Giuffrè, Mohamed Chamkha, Najla Hfaiedh

Herbal medicine is an important field focused on the treatment and prevention of various health conditions that may occur due to oxidative stress. Our investigation aimed to determine the chemical composition, antioxidant, and the protective activity of polysaccharides isolated from Cinnamomum cassia (Cc-Ps). Cc-Ps underwent thorough characterization through various analytical methods, including UV, Fourier Transform Infrared (FTIR) spectroscopy, and HPLC. Our analysis showed that the Cc-Ps exhibited highest amount of uronic acid. In addition, Cc-Ps extract showed high ability to scavenge 2,2 diphenylpicrylhydrazyl radical (DPPH), 2,2′-azinobis-(3 ethylbenzothiazoline-6 sulfonic acid radical (ABTS•+), and NO free radicals in reaction system. There was a noticeable decrease in the activity of key antioxidant enzymes such a superoxide dismutase and glutathione (GSH) peroxidase accompanied by an increase in malondialdehyde, a marker of oxidative stress. MET led to a clear impairment of the histopathological structure of both the liver and kidneys. Pretreatment with the polysaccharide extract normalized all biochemical and oxidative parameters. Virtual screening using docking simulations against “Drosophila melanogaster Acetylcholinesterase” was conducted to assess the bio-insecticidal properties of specific polysaccharide compounds derived from C. cassia. Polysaccharides were effectively protective in the liver and kidneys against the toxic effects of MET under our experimental conditions.

草药是一个重要的领域,专注于治疗和预防各种健康状况,可能发生由于氧化应激。本研究旨在研究肉桂(Cinnamomum cassia, Cc-Ps)多糖的化学成分、抗氧化活性和保护活性。Cc-Ps通过各种分析方法进行了全面的表征,包括UV,傅里叶变换红外(FTIR)光谱和HPLC。我们的分析表明,Cc-Ps表现出最高的醛酸含量。此外,Cc-Ps提取物对反应体系中的2,2二苯基吡啶肼基自由基(DPPH●)、2,2′-氮唑-(3乙基苯并噻唑啉-6磺酸自由基(ABTS•+)和NO自由基具有较强的清除能力。关键抗氧化酶如超氧化物歧化酶和谷胱甘肽(GSH)过氧化物酶的活性明显下降,并伴有丙二醛(氧化应激的标志)的增加。MET导致肝脏和肾脏的组织病理结构明显受损。多糖提取物预处理使所有生化和氧化参数正常化。利用对接模拟对“黑腹果蝇乙酰胆碱酯酶”进行虚拟筛选,评价决明子中特定多糖化合物的生物杀虫性能。在我们的实验条件下,多糖有效地保护肝脏和肾脏免受MET的毒性作用。
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引用次数: 0
Reviewing Marine Bioactive Compounds From the Red Sea: Advancing Therapeutic Applications While Navigating Translational and Conservation Challenges 回顾来自红海的海洋生物活性化合物:在导航转化和保护挑战的同时推进治疗应用。
IF 2.5 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2026-01-21 DOI: 10.1002/cbdv.202502652
Mohammed F. Hawwal, Nadeem Sayyed, Omer I. Fantoukh, Gadah A. AlHamoud, Sarfaraz Ahmed, Saleh I. Alqasoumi, Perwez Alam

The Red Sea, a biologically rich marine ecosystem, is a promising source of novel bioactive compounds with significant therapeutic potential. This review analyzes a decade of research on the isolation, characterization, and biological activities of compounds obtained from sponges, corals, microalgae, seaweeds, marine fish, and microorganisms. These bioactive molecules, including alkaloids, glycosides, terpenes, and peptides, exhibit antimicrobial, anticancer, anti-inflammatory, and neuroprotective properties. Various extraction techniques, ranging from traditional solvent extraction to advanced methods such as supercritical fluid and ultrasound-assisted extraction, aid in their isolation. Meanwhile, chromatographic purification and bioassay-guided fractionation enhance their identification. However, challenges such as limited availability, complex extraction processes, and regulatory constraints hinder the clinical translation of these technologies. Addressing these barriers requires innovative extraction strategies, advanced characterization techniques, and interdisciplinary approaches that integrate marine biology with emerging technologies, such as deep learning. Future research should focus on exploring molecular interactions within coral reef ecosystems, unraveling marine bacterial diversity, and implementing conservation strategies to protect the Red Sea's unique biodiversity while accelerating drug discovery.

红海是一个生物丰富的海洋生态系统,是具有重要治疗潜力的新型生物活性化合物的有希望的来源。本文综述了近十年来从海绵、珊瑚、微藻、海藻、海鱼和微生物中提取的化合物的分离、表征和生物活性的研究进展。这些生物活性分子,包括生物碱、糖苷、萜烯和多肽,具有抗菌、抗癌、抗炎和神经保护特性。各种提取技术,从传统的溶剂提取到先进的方法,如超临界流体和超声波辅助提取,都有助于分离它们。同时,色谱纯化和生物测定引导分离提高了它们的鉴别能力。然而,诸如有限的可用性、复杂的提取过程和监管限制等挑战阻碍了这些技术的临床转化。解决这些障碍需要创新的提取策略、先进的表征技术以及将海洋生物学与新兴技术(如深度学习)相结合的跨学科方法。未来的研究应侧重于探索珊瑚礁生态系统中的分子相互作用,揭示海洋细菌多样性,并实施保护策略,以保护红海独特的生物多样性,同时加速药物发现。
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引用次数: 0
Electrospun Polyvinyl Alcohol/Polyethylene Oxide Loaded With Cisplatin as a Potential Candidate for Anticancer and Antibacterial Drugs 静电纺聚乙烯醇/聚氧化物负载顺铂作为抗癌和抗菌药物的潜在候选药物。
IF 2.5 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2026-01-18 DOI: 10.1002/cbdv.202502566
Mohamed Gaber, El-Refaie Kenawy, Hamed A. Abosharaf, Horrya T. Seleem, Abdalla M. Khedr

One of the most crucial approaches to treating some aggressive diseases, like cancer, is to either discover new medications or to refine and adapt those that already exist. Among these approaches is the drug delivery system, which could help reduce drug doses and side effects. In the existing endeavor, cisplatin (CIS) was loaded on polyvinyl alcohol/polyethylene oxide nanofiber (PVA-PEO-CIS) by the electrospinning method. The fabricated nanofiber was characterized, and its anticancer impact against cervical cancer cells (HeLa) was measured. Also, its antibacterial effect was studied. The obtained findings indicated that (PVA-PEO-CIS) nanofiber inhibits HeLa growth with a half-maximal inhibitory concentration (IC50) of 19.82 µg/mL compared to free CIS (IC50 = 26.31 µg/mL). Importantly, the nanofiber was less toxic to normal WI-38 cells compared to free CIS. The improvement of the anticancer action of CIS was consistent with CIS release studies that indicated about 50% of CIS was released from nanofibers within 8 h. Further, PVA-PEO-CIS nanofiber showed potent bactericidal impact against different bacterial strains, including Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus. For several biological applications, including tumor therapy and antibacterial research, PVA-PEO-CIS may be a potential medication candidate.

治疗一些侵袭性疾病,如癌症,最关键的方法之一是要么发现新的药物,要么改进和调整现有的药物。这些方法之一是药物输送系统,它可以帮助减少药物剂量和副作用。在现有的研究中,采用静电纺丝法将顺铂(CIS)负载在聚乙烯醇/聚氧聚乙烯纳米纤维(PVA-PEO-CIS)上。对制备的纳米纤维进行了表征,并测定了其对宫颈癌细胞(HeLa)的抗癌作用。并对其抗菌效果进行了研究。结果表明,(PVA-PEO-CIS)纳米纤维对HeLa的抑制浓度(IC50 = 26.31 μ g/mL)为19.82µg/mL。重要的是,与游离CIS相比,纳米纤维对正常WI-38细胞的毒性更小。CIS的抗癌作用的提高与CIS的释放研究一致,研究表明约50%的CIS在8小时内从纳米纤维中释放出来。此外,PVA-PEO-CIS纳米纤维对不同的细菌菌株,包括大肠杆菌、肺炎克雷伯菌和葡萄球菌,都有很强的杀菌作用。对于包括肿瘤治疗和抗菌研究在内的一些生物学应用,PVA-PEO-CIS可能是一种潜在的候选药物。
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引用次数: 0
GC–MS Profiling, Antioxidant, Enzyme Inhibition, Molecular Docking, and ADME Investigation of the n-Hexane Extract and the Essential Oil of Platycladus orientalis (L.) Franco Fruits 侧柏精油和正己烷提取物的气相色谱-质谱分析、抗氧化、酶抑制、分子对接及ADME研究弗朗哥的水果。
IF 2.5 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2026-01-18 DOI: 10.1002/cbdv.202502727
Omayma A. Eldahshan, Nilofar Nilofar, Gokhan Zengin, Abdullahi Ibrahim Uba, Doaa A. Korany

Platycladus orientalis (L.) Franco is an evergreen conifer widely used in folk medicine. However, few studies have explored the volatile composition of its fruits. The present study aimed to perform a comparative gas chromatography–mass spectrometry (GC–MS) profiling of the fruit essential oil and n-hexane extract, with assessment of the antioxidant and enzyme inhibitory potentials. In silico molecular docking and predictive absorption, distribution, metabolism, and excretion (ADME) profiling of the main identified components were adopted to support the obtained results. Results revealed that the hydrodistilled oil was dominated by monoterpene hydrocarbons (91.70%), with α-pinene (55.83%) as the main component. The n-hexane extract was dominated by diterpenoids (24.65%) and monoterpene hydrocarbons (25.46%), with 10-nonacosanol being the major component (18.95%). Both samples showed antioxidant properties. The hydrodistilled oil exhibited higher performance, indicated by ferric reducing antioxidant power (FRAP) and total antioxidant capacity assays. The n-hexane extract exhibited higher cupric reducing antioxidant capacity (CUPRAC) and metal chelating ability (MCA) activities. Both samples showed inhibition of acetylcholinesterase, butyrylcholinesterase, and tyrosinase enzymes. α-Amylase and α-glucosidase enzymes were only inhibited by the n-hexane extract, indicating its blood glucose management effect. The molecular docking and predictive ADME analyses supported the obtained results. These findings revealed that the extraction method markedly influenced the chemical composition and biological activity, highlighting the potential for treating dysregulated-enzyme conditions in addition to the health-promoting application of the essential oil in the food and pharmaceutical industries.

侧柏(L.)佛朗哥是一种常绿针叶树,广泛用于民间医学。然而,很少有研究探索其果实的挥发性成分。本研究旨在通过气相色谱-质谱(GC-MS)对比分析水果精油和正己烷提取物,并评估其抗氧化和酶抑制电位。在硅分子对接和预测的吸收,分布,代谢和排泄(ADME)分析的主要鉴定组分采用支持所得结果。结果表明:加氢蒸馏油以单萜烃为主(91.70%),α-蒎烯为主要成分(55.83%);正己烷萃取物以二萜(24.65%)和单萜(25.46%)为主,10-壬烷醇为主要成分(18.95%)。两种样品均表现出抗氧化性能。通过铁还原抗氧化能力(FRAP)和总抗氧化能力测定,表明加氢蒸馏油具有较高的抗氧化性能。正己烷提取物具有较高的铜还原抗氧化能力(CUPRAC)和金属螯合能力(MCA)活性。两种样品对乙酰胆碱酯酶、丁基胆碱酯酶和酪氨酸酶均有抑制作用。α-淀粉酶和α-葡萄糖苷酶仅被正己烷提取物抑制,说明其血糖管理作用。分子对接和预测ADME分析支持了所得结果。这些发现表明,提取方法显著影响了其化学成分和生物活性,突出了除在食品和制药工业中促进健康应用外,治疗酶失调状况的潜力。
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引用次数: 0
Synthesis of 2-(Quinoxalin-2-yl)acetamides and Their Preliminary Cytotoxic and Antibacterial Activity 2-(喹诺沙林-2-基)乙酰酰胺的合成及其初步细胞毒和抗菌活性。
IF 2.5 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2026-01-18 DOI: 10.1002/cbdv.202503511
Cesar E. Tovar-Roman, Eduardo Hernández-Vázquez, José A. Rivera-Chávez

Quinoxaline is an aza-heterocycle found in some bioactive compounds. Thus, to enhance the pharmacological scope of this nucleus, we report a series of 19 acetamides decorated with a quinoxaline core. The synthesis involved the linkage of previously constructed bromoacetamides and hydroxyphenyl quinoxalines via an SN2 reaction. The first series considered a 1,4-substituted phenyl ring as a linker, and some derivatives showed moderate antibacterial activity against a panel of ESKAPE pathogens, especially against methicillin-resistant Staphylococcus aureus (inhibition ranging from 10% to 60% at 100 µM). Interestingly, the activity dropped in the 1,3- and 1,2-regioisomers. Furthermore, we tested the series against relevant human cancer cell lines, in which the ethyl derivative 10c inhibited the growth of breast, prostate, and colon tumors (43%, 48%, and 66%, respectively), whereas COS-7 cells showed only 7.8% inhibition. Although these are preliminary in vitro findings, we corroborate the applicability of the quinoxaline heterocycle in the design of potential candidates against relevant pathologies.

喹啉是一种偶氮杂环,存在于一些生物活性化合物中。因此,为了增强该核的药理学范围,我们报道了一系列19种以喹诺啉核心装饰的乙酰胺。该合成涉及先前构建的溴乙酰胺和羟基苯基喹啉通过SN2反应连接。第一个系列采用1,4-取代苯环作为连接剂,一些衍生物对ESKAPE病原菌表现出适度的抗菌活性,特别是对耐甲氧西林金黄色葡萄球菌(在100µM下抑制10%至60%)。有趣的是,1,3-和1,2-区域异构体的活性下降了。此外,我们对该系列对相关人类癌细胞系进行了测试,其中乙基衍生物10c对乳腺癌、前列腺癌和结肠癌肿瘤的生长抑制作用分别为43%、48%和66%,而COS-7细胞的抑制作用仅为7.8%。虽然这些是初步的体外研究结果,但我们证实了喹诺啉杂环在设计针对相关病理的潜在候选药物中的适用性。
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引用次数: 0
Assessment of In Vitro Antioxidant Activity and Subacute Toxicity and Safety of Tetrahydroserpentine in Hyperglycemic Mice 四氢蛇纹汀对高血糖小鼠体外抗氧化活性及亚急性毒性和安全性评价。
IF 2.5 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2026-01-18 DOI: 10.1002/cbdv.202502261
Ashim Chandra Roy, Komal Priya, Abhinav Prasad, Prabhat Kumar, Raman Deep Sharma, Anuradha Kumari, Ilora Ghosh

Tetrahydroserpentine (ThS), an indole alkaloid and α1‑adrenergic receptor blocker, is used for treating hypertension, a condition often linked with diabetic pathophysiology. However, its toxicological profile and safety under hyperglycemic conditions remain unclear. This study aimed to assess the antioxidant activity, subacute toxicity, and effect of ThS under hyperglycemic conditions using in silico, in vitro, and in vivo approaches. In vitro toxicity analysis demonstrated that ThS exhibited dose-dependent cytotoxicity in both cancerous and noncancerous cells at ≥ 25 µM. It showed moderate antioxidant activity by reducing H2O2-induced ROS, although its antioxidant effect declined with time. In silico network pharmacology predicted 110 targets involved in metabolic, inflammatory, and proliferative pathways. In vivo subacute toxicity studies in mice showed that oral doses ≥ 5.0 mg/kg/day led to liver and kidney damage, as evidenced by altered hematological, biochemical, and histological parameters. A lower dose (2.5 mg/kg/day) was identified as non-toxic and used in streptozotocin-induced hyperglycemic mice. At this dose, ThS did not improve hyperglycemia-induced liver and kidney damage and, notably, worsened serum SGOT and urea levels. These findings highlight that while ThS possesses limited antioxidant capacity, it can be toxic at higher doses and harmful under hyperglycemic conditions. Further studies are required to ensure its safe therapeutic use in hyperglycemic conditions.

四氢蛇纹碱(ThS)是一种吲哚类生物碱和α1 -肾上腺素能受体阻滞剂,用于治疗高血压,这种疾病通常与糖尿病病理生理有关。然而,其毒理学特征和在高血糖条件下的安全性仍不清楚。本研究旨在通过体内、体外和体内方法评估三手藤在高血糖状态下的抗氧化活性、亚急性毒性和作用。体外毒性分析表明,在≥25µM时,三叶草对癌细胞和非癌细胞均表现出剂量依赖性的细胞毒性。通过降低h2o2诱导的活性氧表现出中等的抗氧化活性,但其抗氧化作用随时间的延长而下降。计算机网络药理学预测了110个涉及代谢、炎症和增殖途径的靶点。小鼠体内亚急性毒性研究表明,口服剂量≥5.0 mg/kg/天会导致肝脏和肾脏损伤,血液、生化和组织学参数发生改变。较低剂量(2.5 mg/kg/天)被确定为无毒,并用于链脲佐菌素诱导的高血糖小鼠。在这个剂量下,三叶草并没有改善高血糖引起的肝脏和肾脏损害,而且,值得注意的是,血清SGOT和尿素水平恶化。这些发现强调,虽然三叶草具有有限的抗氧化能力,但它在高剂量下可能是有毒的,在高血糖条件下是有害的。需要进一步的研究来确保其在高血糖条件下的安全治疗。
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引用次数: 0
Antioxidant, Antimicrobial, and Molecular Binding Affinity Applications of Green-Synthesized Nickel Oxide Nanoparticles 绿色合成的氧化镍纳米颗粒在抗氧化、抗菌和分子结合方面的应用。
IF 2.5 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2026-01-18 DOI: 10.1002/cbdv.202502684
Kuruvalli Gouthami, P. C. Nagajyothi, R. Vijaya, Subhasish Maity, Ayantika Santra, K. Pavani, Vaddi Damodara Reddy, Jaesool Shim

The preparation of metal or metal oxide nanoparticles (NPs) using the green method is rapid, low-cost, and eco-friendly. In this study, nickel oxide NPs (NiO NPs) were synthesized using Foeniculum vulgare seed extract. The green-synthesized NiO NPs were characterized by X-ray diffraction, X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM) techniques. SEM and TEM images revealed spherical and sheet-like morphologies. The NiO NPs exhibited notable antioxidant, antimicrobial, and molecular interaction properties. Antioxidant activity was evaluated using DPPH+ and ABTS+ assays, showing IC50 values of 12.68 ± 0.56 and 11.82 ± 0.84 µg/mL, respectively, compared to standard antioxidants ascorbic acid (8.94 ± 2.2 µg/mL) and gallic acid (1.2 ± 0.67 µg/mL). Antibacterial assays against Staphylococcus aureus, Bacillus sp., Pseudomonas aeruginosa, and Escherichia coli revealed concentration-dependent inhibition, with maximum zones of inhibition at 80 µg/mL, measuring 7.86 mm for E. coli and 7.21 mm for S. aureus. Antifungal activity showed dose-dependent inhibition of Aspergillus niger (6.00–7.96 mm) but minimal effect on Fusarium sp. (6.00–6.03 mm), compared to ketoconazole controls (9.36 and 9.21 mm, respectively). Molecular docking revealed strong binding affinities of NiO NPs with P. aeruginosa (−9.9 kcal/mol) and A. niger endoglucanase (−8.5 kcal/mol), comparable to streptomycin (−11.1 kcal/mol) and ketoconazole (−10.0 kcal/mol). These findings highlight the promising antioxidant and antimicrobial potential of NiO NPs for biomedical applications.

使用绿色方法制备金属或金属氧化物纳米颗粒(NPs)具有快速、低成本和环保的特点。本研究以小茴香种子提取物为原料合成了氧化镍NPs (NiO NPs)。采用x射线衍射、x射线光电子能谱、傅里叶变换红外光谱、扫描电子显微镜(SEM)和透射电子显微镜(TEM)等技术对绿色合成的NiO NPs进行了表征。SEM和TEM图像显示为球形和片状形貌。NiO NPs具有显著的抗氧化、抗菌和分子相互作用特性。采用DPPH+和ABTS+试验评估其抗氧化活性,与抗坏血酸(8.94±2.2µg/mL)和没食子酸(1.2±0.67µg/mL)相比,IC50值分别为12.68±0.56和11.82±0.84µg/mL。对金黄色葡萄球菌、芽孢杆菌、铜绿假单胞菌和大肠杆菌的抑菌试验显示出浓度依赖性的抑制作用,最大抑制区为80µg/mL,大肠杆菌为7.86 mm,金黄色葡萄球菌为7.21 mm。与酮康唑对照(分别为9.36和9.21 mm)相比,酮康唑对黑曲霉(6.00-7.96 mm)的抑制作用呈剂量依赖性,对镰刀菌(6.00-6.03 mm)的抑制作用最小。分子对接发现,NiO NPs与铜绿假单胞菌(P. aeruginosa)和A. niger内切葡聚糖酶(A. niger内切葡聚糖酶)具有较强的结合亲和力(-9.9 kcal/mol),与链霉素(-11.1 kcal/mol)和酮康唑(-10.0 kcal/mol)相当。这些发现突出了NiO NPs在生物医学应用中的抗氧化和抗菌潜力。
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引用次数: 0
Unveiling Bioactive Compounds of Endemic Ornithogalum yesilyurtense: A First Comprehensive Study 地方病鸟瘿菌(Ornithogalum yesilyurtense)生物活性化合物的首次综合研究。
IF 2.5 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2026-01-18 DOI: 10.1002/cbdv.202502920
Melek Demir Perçin, Abuzer Çelekli, Yener Tekeli, Ömer Kılıç

Ornithogalum yesilyurtense Yıld. & Kılıç is a newly described endemic geophyte from Türkiye. This study offers the first comprehensive phytochemical and pharmacological profile of the plant. Methanol extracts taken from the aerial and bulb parts were assessed for antioxidant and antimicrobial properties. LC–MS/MS and GC–MS were used to further examine the phenolic and fatty acid contents. The aerial parts showed higher total phenolic content (TPC: 0.194 mg GAE/g), and antioxidant activity (more ferric reducing power [FRAP]: 0.784 µM Fe2+/g, and a lower DPPH IC50: 1.645 µg/mL) than that of the bulbs (TPC: 0.148 mg GAE/g; FRAP: 0.285 µM Fe2+/g; DPPH IC50: 2.17 µg/mL). Palmitic, linolenic, and γ-linolenic acids predominated in the aerial parts, while cis-linoleic and palmitic acids were dominant in bulbs. Resveratrol, hydroxycinnamic acid, and vanillic acid were the main phenolics in aerial parts, whereas ellagic, hydroxycinnamic, and gallic acids were abundant in bulbs. Both exhibited notable antioxidant, antimicrobial, and antifungal activities. Overall, O. yesilyurtense represents a promising new source of bioactive compounds with potential applications in pharmaceutical and functional food formulations.

Ornithogalum yesilyurtense Yıld。& Kılıç是一种新发现的基耶岛特有地植物。这项研究提供了第一个全面的植物化学和药理学的植物概况。从茎部和球茎部分提取的甲醇提取物进行了抗氧化和抗菌性能的评估。采用LC-MS/MS和GC-MS进一步测定酚类和脂肪酸含量。与球茎(TPC: 0.148 mg GAE/g, FRAP: 0.285µM Fe2+/g, DPPH IC50: 2.17µg/mL)相比,地上部分总酚含量(TPC: 0.194 mg GAE/g)和抗氧化活性(更强的铁还原能力[FRAP]: 0.784µM Fe2+/g, DPPH IC50: 1.645µg/mL)更高。地上部以棕榈酸、亚麻酸和γ-亚麻酸为主,鳞茎部以顺式亚油酸和棕榈酸为主。白藜芦醇、羟基肉桂酸和香草酸是地上部位的主要酚类物质,鳞茎中含有丰富的鞣花酸、羟基肉桂酸和没食子酸。两者均表现出显著的抗氧化、抗菌和抗真菌活性。总的来说,O. yesilyurtense代表了一种有前景的生物活性化合物的新来源,在制药和功能性食品配方中具有潜在的应用。
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引用次数: 0
Novel Pyrazolo[3,4-b]pyridines: Synthesis, Molluscicidal, and Antimicrobial Activities 新型吡唑[3,4-b]吡啶:合成、杀螺及抗菌活性
IF 2.5 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2026-01-18 DOI: 10.1002/cbdv.202502380
Ahmed Abdou O. Abeed, Sarra Rafrafi, Heba Alsharif, Tarek H. Afifi, Sahar I. M. Abd El-Wahed, Hesham A. M. Ibrahim

Monacha obstructa, a widespread land snail in Egypt, causes severe damage to various agricultural crops. The extensive use of conventional chemical pesticides has led to resistance development, reducing their effectiveness in pest management. Therefore, there is an urgent need for novel and rational molluscicidal agents. In this study, new pyrazolopyridine-derived heterocycles (compounds 27) were synthesized and evaluated for their molluscicidal activity against M. obstructa in comparison with several reference insecticides. The molecular structures of the synthesized compounds were confirmed using FTIR, 1H and 13C NMR, and mass spectrometry analyses. Following seven consecutive days of exposure, deltamethrin, methomyl, tolfenpyrad, and the 2-pyrazoline derivatives 3, 4, and 7 exhibited significant toxicity, whereas compounds 2, 5, and 6 displayed moderate effects. These findings suggest that the synthesized compounds are promising candidates for developing new molluscicides. Furthermore, their antibacterial and antifungal activities were assessed, revealing that compounds 3, 4, and 6 could serve as potential precursors for the development of antimicrobial agents.

在埃及广泛分布的一种陆地蜗牛,对各种农作物造成严重破坏。常规化学农药的广泛使用导致抗药性的产生,降低了它们在虫害管理方面的有效性。因此,迫切需要新型合理的杀螺剂。本文合成了新的吡唑吡啶类杂环化合物(化合物2 ~ 7),并与几种参比杀虫剂进行了杀螺活性比较。合成化合物的分子结构通过FTIR、1H、13C NMR和质谱分析得到了证实。在连续暴露7天后,溴氰菊酯、灭多威、苯氰菊酯和2-吡唑啉衍生物3、4和7表现出明显的毒性,而化合物2、5和6表现出中等的毒性。这些发现表明,合成的化合物是开发新型杀螺剂的有希望的候选者。对化合物3、4、6的抑菌活性进行了评价,认为化合物3、4、6可作为开发抗菌药物的前体物质。
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引用次数: 0
Acanthospermum hispidum and Its Metabolite Stigmasterol Modulates Anti-Inflammatory Antagonism of COX-1 and TGF-β 棘棘皮及其代谢物豆甾醇调节COX-1和TGF-β的抗炎拮抗作用。
IF 2.5 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2026-01-18 DOI: 10.1002/cbdv.202501647
Onome Mary Adeboye, Abimbola Sowemimo, Muyiwa Samuel Fageyinbo, Oluwasegun Adedokun, Abdul Basit, Opeyemi Joshua Olatunji, Epole Ngolle Ntungwe

Acanthospermum hispidum (AH) leaves have been widely used in traditional medicine for inflammation. In this study, the anti-inflammatory effect of AH was evaluated, and a possible mechanism was predicted using an in silico model. The in vivo anti-inflammatory activity of the AH extract was carried out using carrageenan, histamine and serotonin-induced rat paw oedema, whereas molecular docking was used against all receptors implicated with inflammation. AH extract showed significant (p < 0.01) inhibition at 50, 100, 150 and 200 mg/kg with all the models used (p ˂ 0.05 to ˂0.0001) with a non-significant decrease at T180; there were significances at some dose levels (e.g., 150 and 200 mg/kg). The peak percentage inhibition of the extract occurred at a dose of 100 mg/kg. A dose-dependent increase in anti-inflammatory activity was noted across the time examined T30—T150 with a non-significant decrease at T180. F1 was found to be the most active fraction. However, stigmasterol showed a potent antagonist influence on COX-1, COX-II, CAT and INF-gamma by showing binding affinities of −8.9, −8.9, −8.8 and −8.4 kcal/mol, respectively. Moreover, alkyl, carbon-hydrogen, conventional hydrogen and van der Waals interactions were noted. Stigmasterol was observed to obey the Lipinski rule of five except MLOGP. These findings justify the ethnomedicinal information of the usage of AH in the management of inflammation and related ailments.

棘棘皮(AH)叶在传统医学中被广泛用于治疗炎症。在本研究中,我们评估了AH的抗炎作用,并利用计算机模型预测了其可能的机制。用卡拉胶、组胺和5 -羟色胺诱导的大鼠足跖水肿来研究AH提取物的体内抗炎活性,而用分子对接来对抗所有与炎症有关的受体。AH提取物显示显著(p
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引用次数: 0
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