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Phenolic Components And Biological Activity Of Pomegranate. 石榴的酚类成分和生物活性。
IF 2.3 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-12 DOI: 10.1002/cbdv.202402301
Qin-Shi Zhao, Zhiping Zhou, Chaoyan Ma, Liyan Peng, Pengchao Hao, Sophia Yi Zhang

Pomegranate (Punica granatum L.) have been subject of extensive studies for its abundance of phytochemicals and numerous biological and medicinal properties. It is a fruit-bearing tree, which is widely consumed as a nutraceutical source as well as functional food for putative health benefits. The phenolic components are the characteristic bioactive constitutes of pomegranate, including hydrolysable tannins, flavonoids, and phenolic acids. The whole plant of this tree has many medicinal folkloric uses and good therapeutic effect, such as anticancer, antioxidant, antibacterial, antiviral, hypoglycemic, lipid-lowering, cardioprotection and digestive system protection. Through comprehensive search of available literature, this narrative review can provide an up-to-date overview of the current knowledge of characteristic bioactive constituents's structure and potential health benefits of Pomegranate, which can be used as reference for the future clinical and basic research, and also helpful for the development of pomegranate into functional food and nutraceuticals.

石榴(Punica granatum L.)因其丰富的植物化学物质和众多的生物和药用特性而成为广泛研究的对象。石榴是一种果树,作为一种营养保健品和功能性食品被广泛食用,对健康大有裨益。酚类成分是石榴特有的生物活性成分,包括可水解单宁、黄酮类化合物和酚酸。石榴全株具有多种民间药用价值和良好的治疗效果,如抗癌、抗氧化、抗菌、抗病毒、降血糖、降血脂、保护心脏和消化系统等。本综述通过对现有文献的全面检索,对目前有关石榴特征生物活性成分的结构和潜在保健作用的知识进行了最新概述,可为今后的临床和基础研究提供参考,也有助于将石榴开发成功能食品和营养保健品。
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引用次数: 0
Synthesis, Urease Inhibitory Activity, Molecular Docking, Dynamics, MMGBSA and DFT Studies of Hydrazone-Schiff Bases Bearing Benzimidazole Scaffold. 含苯并咪唑支架的希夫碱的合成、尿素酶抑制活性、分子对接、动力学、MMGBSA 和 DFT 研究。
IF 2.3 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-12 DOI: 10.1002/cbdv.202402096
Abdul Shakoor, Faheem Jan, Sudais Rahman, Mumtaz Ali, Muhammad Ibrahim, Hammad Khan, Aftab Alam, Ajmal Khan, Abid Ali, Ebtesam Al-Olayan, Mostafa R Abukhadra, Ahmed Al-Harrasi, Momin Khan

In this study, eleven hydrazone-Schiff bases bearing benzimidazole moiety were synthesized successfully via three step reactions and structures of these products were deduced by HR-ESI-MS, 1H-, and 13C-NMR spectroscopic techniques. Lastly, these derivatives were tested for their in vitro urease inhibitory potential. Six compounds among the series attributed excellent inhibition with IC50 values of 7.20±0.59 to 19.61±1.10 μM better than the reference drug thiourea (IC50=22.12±1.20 μM). Similarly, three derivatives showed significant while two compounds showed less inhibitory effects against the urease enzyme. The molecular docking analysis was carried out to reveal the binding modes and types of interaction taking place between protein (urease) and synthesized compounds. The Density Functional Theory (DFT) calculations were performed at B3LYP/6-311++G(d,p) to check the structure stability. For the account of intramolecular interaction, the DFT-D3 and Reduced Density Gradient (RDG) analysis were performed. Furthermore, the chemical nature of all compounds was explored by TD-DFT method using CAM-B3LYP functional with 6-311++G(d,p) basis set. The dynamic simulation as well as MMGBSA studies validated the binding affinity and stability of the ligand receptor complex, displaying main interactions contributing in the biological activity of the product derivatives.

本研究通过三步反应成功合成了十一种含有苯并咪唑分子的腙-希夫碱,并利用 HR-ESI-MS、1H- 和 13C-NMR 光谱技术推断了这些产物的结构。最后,对这些衍生物进行了体外脲酶抑制潜力测试。该系列中的六个化合物具有出色的抑制作用,其 IC50 值为 7.20 ± 0.59 至 19.61 ± 1.10 µM,优于参考药物硫脲(IC50 = 22.12 ± 1.20 µM)。同样,三种衍生物对脲酶的抑制作用明显,而两种化合物的抑制作用较弱。为了揭示蛋白质(尿素酶)与合成化合物之间的结合模式和相互作用类型,我们进行了分子对接分析。在 B3LYP/6-311++G(d,p) 下进行了密度泛函理论(DFT)计算,以检验结构的稳定性。为了考虑分子内相互作用,还进行了 DFT-D3 和还原密度梯度(RDG)分析。此外,还使用 6-311++G(d,p) 基集的 CAM-B3LYP 函数,通过 TD-DFT 方法探讨了所有化合物的化学性质。动态模拟和 MMGBSA 研究验证了配体受体复合物的结合亲和力和稳定性,显示了有助于提高产品衍生物生物活性的主要相互作用。
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引用次数: 0
Benzylidenehydrazine Derivatives: Synthesis, Antidiabetic Evaluation, Antioxidation, Mode of Inhibition, DFT and Molecular Docking Studies. 苯亚肼衍生物:合成、抗糖尿病评价、抗氧化、抑制模式、DFT 和分子对接研究。
IF 2.3 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-12 DOI: 10.1002/cbdv.202401556
Pule Seboletswe, Gobind Kumar, Nontobeko Gcabashe, Kolawole Olofinsan, Shahidul Islam, ALmahi Idris, Parvesh Singh

Diabetes mellitus (DM) is a metabolic condition that is a profound health concern across the globe due to its contribution to the increased mortality rate. It affects millions of people around the world and is associated with severe complications among people diagnosed with it. Among the array of approaches used for the management of DM, inhibition of enzymes viz. α-amylase and α-glucosidase which are responsible for sugars hydrolysis is regarded as a feasible therapeutic protocol for the management of DM. Herein, we report the synthesis of benzylidenehydrazine derivatives as well as their evaluation as α-glucosidase and α-amylase inhibitors including their antioxidant testing. Generally, all the synthesized derivatives were more potent inhibitors of α-amylase than of α-glucosidase. Specifically, 2,4 fluoro substituted analogue 9 (IC50 =116.19 μM) emerged as the strongest α-amylase inhibitor with ~5-fold superior activity in comparison to the standard drug, acarbose (IC50 =600 μM). Compounds 18 (IC50 =240.59) and 19 (IC50 =198.32 μM) displayed the strongest NO scavenging activity compared to Trolox (IC50 =272.36 μM). In addition, the enzyme kinetic studies indicated that compound 9 acts as a non-competitive inhibitor of α-amylase. Finally, density functional theory and molecular docking studies for compound 9 were conducted to explore its structural and electronic properties as well as to determine protein-ligand interactions, respectively to decipher its observed activity. The obtained findings present promising possibilities for developing new drug candidates to control postprandial glucose levels in persons with diabetes.

糖尿病(DM)是一种新陈代谢疾病,因其导致死亡率上升而成为全球范围内令人深感忧虑的健康问题。它影响着全球数百万人,并给确诊患者带来严重的并发症。在此,我们报告了苄叉肼衍生物的合成及其作为α-葡萄糖苷酶和α-淀粉酶抑制剂的评估,包括其抗氧化测试。一般来说,所有合成的衍生物对α-淀粉酶的抑制作用都强于对α-葡萄糖苷酶的抑制作用。具体来说,2,4-氟取代的类似物 9(IC50 =116.19 µM)是最强的α-淀粉酶抑制剂,其活性比标准药物阿卡波糖(IC50 = 600 µM)高出约 5 倍。与三氯氧磷(IC50 = 272.36 µM)相比,化合物 18(IC50 = 240.59)和 19(IC50 = 198.32 µM)显示出最强的氮氧化物清除活性。此外,酶动力学研究表明,化合物 9 是一种非竞争性的 α 淀粉酶抑制剂。最后,对化合物 9 进行了密度泛函理论和分子对接研究,分别探讨了其结构和电子特性,并确定了蛋白质与配体之间的相互作用,以解读其观察到的活性。
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引用次数: 0
Exploring the Antisnake Venom Potential of Zingiber officinale and its Bioactive Compounds Against Naja nigricollis Venom Through Computational Approaches and Experimental Validation. 通过计算方法和实验验证,探索细辛及其生物活性化合物对 Naja nigricollis 毒液的抗蛇毒潜力。
IF 2.3 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-11 DOI: 10.1002/cbdv.202402449
Amina J Yusuf, Nasir Ibrahim, Musa I Abdullahi, Abayomi E Adeboyega, Mustapha Salihu

Snakebite envenomation remains a significant medical challenge, particularly in tropical and subtropical regions. The present study investigates the inhibitory potential of Zingiber officinale (ginger) and its bioactive compounds against Naja nigricollis venom using in silico approaches and animal models. No protection was observed in the in vivo studies but the extract of the plant was able to prolong the time of death with mean survival time ranging from 2.01-2.83 hours. In terms of the in vitro studies, the extract was able to significantly (p<0.05) detoxify the N. nigricollis venom by 80 % at the graded doses; standard antisnake venom (ASV) offered 100 % protection to mice. Molecular docking analysis revealed strong binding affinities between the bioactive compounds and the PLA2 enzyme, indicating potential inhibitory effects. The stability and dynamics of the protein-ligand complexes were further validated through molecular dynamics (MD) simulations, which confirmed the persistence of these interactions over time. In conclusion, the findings suggest that the bioactive compounds from Z. officinale could serve as promising inhibitors of PLA2, providing a foundation for the development of novel snakebite envenomation therapies.

毒蛇咬伤仍是一项重大的医学挑战,尤其是在热带和亚热带地区。本研究利用硅学方法和动物模型研究了姜及其生物活性化合物对黑颈蛇毒液的抑制潜力。在体内研究中没有观察到保护作用,但该植物的提取物能够延长死亡时间,平均存活时间为 2.01 - 2.83 小时。在体外研究中,该提取物能够显著(p
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引用次数: 0
Anti-Inflammatory Secoiridoids from the Medicinal Herb Gentianopsis barbata. 药用植物龙胆中的抗炎萃取物
IF 2.3 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-11 DOI: 10.1002/cbdv.202402653
Huan Liu, Hui-Zhen Cheng, Xiao-Yu Qi, Yu-Zhou Fan, Zhong-Zhu Yuan, Yuan-Liang Xu, Yan Liu, Kai Guo, Sheng-Hong Li

Five new secoiridoids, gentianopsins A-E (1-5), along with two known analogues (6 and 7) were isolated from the whole plants of the medicinal herb Gentianopsis barbata. Their structures were elucidated by a comparison of extensive spectroscopic analysis (1D and 2D NMR, and HRMS) and quantum chemical calculations. Gentianopsins A (1) and B (2) represented two unusual skeletons of trihomo-secoiridoids. Anti-inflammatory activity of these isolates was evaluated via suppressing the secretion of cytokines TNF-α and IL-6 in LPS-induced macrophages RAW264.7. Significant inhibitory activity was observed for compounds 3 and 7 on IL-6 secretion with IC50 values of 10.22 and 13.30 μM, respectively.

从药用植物龙胆(Gentianopsis barbata)的全株中分离出了五种新的仲呋喃糖苷类化合物--龙胆肽 A-E(1-5)以及两种已知的类似物(6 和 7)。通过对大量光谱分析(一维和二维核磁共振以及 HRMS)和量子化学计算的比较,阐明了它们的结构。龙胆草素 A(1)和 B(2)代表了两种不同寻常的三卤代海鞘糖苷骨架。通过抑制 LPS 诱导的巨噬细胞 RAW264.7 中细胞因子 TNF-α 和 IL-6 的分泌,评估了这些分离物的抗炎活性。化合物 3 和 7 对 IL-6 的分泌具有显著的抑制活性,IC50 值分别为 10.22 和 13.30 μM。
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引用次数: 0
In vitro Evaluation of Endocrine-Related Adverse Effects of 5-Fluoroindole Derived Melatonin Analogues with Antioxidant Activity. 体外评估具有抗氧化活性的 5-氟吲哚衍生褪黑素类似物与内分泌相关的不良反应。
IF 2.3 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-11 DOI: 10.1002/cbdv.202402050
Elif Ince Erguc, Hanifa Fatullayev, Bita Entezari, Betul Tekiner, Sibel Suzen, Hande Gurer-Orhan

Melatonin (MLT) is a natural indolic hormone and its antioxidant activity has been reported through various mechanisms. MLT interacts with the estrogen signaling pathway by inhibiting aromatase enzyme, and it has been suggested that these new compounds may have endocrine-related adverse effects due to their selective estrogen modulator activity. In this study, we investigated the aromatase inhibitory and estrogen receptor agonist/antagonist effects as well as possible antioxidant activity of MLT analogue 5-floro indole derivatives for being potential drug candidates in the prevention and treatment of oxidative stress related diseases. Among the 34 compounds tested, three compounds showed antioxidant effect through radical scavenging activity and reducing the formation of intracellular reactive oxygen species.  They also showed varying potencies of antiestrogenic and/or aromatase inhibitory activity which should be considered as a potential untargeted effect of MLT and its analogues.

褪黑素(MLT)是一种天然吲哚类激素,其抗氧化活性已通过各种机制得到报道。MLT 通过抑制芳香化酶与雌激素信号通路相互作用,有人认为这些新化合物可能因其选择性雌激素调节剂活性而产生与内分泌相关的不良反应。在这项研究中,我们研究了 MLT 类似物 5-氯吲哚衍生物的芳香化酶抑制和雌激素受体激动剂/拮抗剂效应以及可能的抗氧化活性,以作为预防和治疗氧化应激相关疾病的潜在候选药物。在测试的 34 种化合物中,有三种化合物通过自由基清除活性和减少细胞内活性氧的形成而显示出抗氧化作用。 它们还显示出不同效力的抗雌激素和/或芳香化酶抑制活性,这应被视为 MLT 及其类似物的潜在非靶向效应。
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引用次数: 0
COF-SO3H-Catalyzed Synthesis of Pyrazoline-Pyridine Hybrids with Dual Antioxidant and Anti-Inflammatory Activity Targeting PDE4B. COF-SO3H 催化合成具有针对 PDE4B 的抗氧化和抗炎双重活性的吡唑啉-吡啶杂化物。
IF 2.3 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-10 DOI: 10.1002/cbdv.202402457
Nida Khan, Mohd Kamil Hussain, Mohammad Faheem Khan, Zeba N Siddiqui

This study explores new anti-inflammatory agents by synthesizing pyrazoline-pyridine hybrids with N-butylsulfonated covalent organic framework (COF-SO3H) as a recyclable catalyst, achieving excellent yields in just one minute. The protocol was successfully scaled up to a multi-gram scale, highlighting its robustness and efficiency, and it operates without the need for column chromatography. Among the synthesized hybrids, compound 5d, a pyrazoline-pyridine hybrid bearing an indole moiety, emerged as a potent anti-inflammatory and antioxidant agent. It effectively inhibited PDE4B activation with an IC50 value of 99.38 nM, without adversely affecting HEK cells. Compound 5d demonstrated its dual activity by significantly reducing ROS production and restoring mitochondrial health in LPS-stimulated A549 and HEK cells, while also downregulating IL-1β and NF-ĸB/p65 expression in LPS-stimulated A549 cells. In silico studies confirmed compound 5d's strong binding to PDE4B, with stable RMSD and RMSF values, indicating its potential as a stable and effective PDE4B inhibitor. The compound exhibited favorable physicochemical properties, met drug-likeness criteria, and showed low toxicity as predicted in silico. These findings suggest that compound 5d has significant potential as a therapeutic agent for inflammatory diseases due to its dual anti-inflammatory and antioxidant activities.

本研究通过使用 N-butylsulfonated covalent organic framework (COF-SO3H) 作为可循环催化剂合成吡唑啉-吡啶杂化物,探索新型消炎药,只需一分钟就能获得极高的产率。该方案已成功放大到多克级,凸显了其稳健性和高效性,而且无需柱层析即可操作。在合成的杂交化合物中,化合物 5d 是一种带有吲哚分子的吡唑啉-吡啶杂交化合物,是一种有效的抗炎和抗氧化剂。它能有效抑制 PDE4B 的活化,IC50 值为 99.38 nM,且不会对 HEK 细胞产生不利影响。化合物 5d 在 LPS 刺激的 A549 和 HEK 细胞中显著减少了 ROS 的产生,恢复了线粒体的健康,同时还在 LPS 刺激的 A549 细胞中下调了 IL-1β 和 NF-ĸB/p65 的表达,从而证明了它的双重活性。硅学研究证实了化合物 5d 与 PDE4B 的强结合力,具有稳定的 RMSD 和 RMSF 值,表明其具有作为稳定、有效的 PDE4B 抑制剂的潜力。该化合物表现出良好的理化性质,符合药物相似性标准,并显示出硅学预测的低毒性。这些研究结果表明,化合物 5d 具有抗炎和抗氧化双重活性,因此作为炎症性疾病的治疗药物具有很大的潜力。
{"title":"COF-SO<sub>3</sub>H-Catalyzed Synthesis of Pyrazoline-Pyridine Hybrids with Dual Antioxidant and Anti-Inflammatory Activity Targeting PDE4B.","authors":"Nida Khan, Mohd Kamil Hussain, Mohammad Faheem Khan, Zeba N Siddiqui","doi":"10.1002/cbdv.202402457","DOIUrl":"10.1002/cbdv.202402457","url":null,"abstract":"<p><p>This study explores new anti-inflammatory agents by synthesizing pyrazoline-pyridine hybrids with N-butylsulfonated covalent organic framework (COF-SO<sub>3</sub>H) as a recyclable catalyst, achieving excellent yields in just one minute. The protocol was successfully scaled up to a multi-gram scale, highlighting its robustness and efficiency, and it operates without the need for column chromatography. Among the synthesized hybrids, compound 5d, a pyrazoline-pyridine hybrid bearing an indole moiety, emerged as a potent anti-inflammatory and antioxidant agent. It effectively inhibited PDE4B activation with an IC<sub>50</sub> value of 99.38 nM, without adversely affecting HEK cells. Compound 5d demonstrated its dual activity by significantly reducing ROS production and restoring mitochondrial health in LPS-stimulated A549 and HEK cells, while also downregulating IL-1β and NF-ĸB/p65 expression in LPS-stimulated A549 cells. In silico studies confirmed compound 5d's strong binding to PDE4B, with stable RMSD and RMSF values, indicating its potential as a stable and effective PDE4B inhibitor. The compound exhibited favorable physicochemical properties, met drug-likeness criteria, and showed low toxicity as predicted in silico. These findings suggest that compound 5d has significant potential as a therapeutic agent for inflammatory diseases due to its dual anti-inflammatory and antioxidant activities.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202402457"},"PeriodicalIF":2.3,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enrichment, Antioxidant and Enzyme Inhibition Activities of Flavonoids from Artemisia Selengensis Turcz. 蒿属黄酮类化合物的富集、抗氧化和酶抑制活性
IF 2.3 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-10 DOI: 10.1002/cbdv.202401835
Ting Wang, Weiming Wang, Zhichun Shi, Dan Wang, Jun Li, Liqiu Sun, Ming Zhao

Macroporous resin was used to enrich flavonoids in the ethyl acetate extract of Artemisia Selengensis Turcz. Based on a single factor experiment, the enrichment process was optimized using the response surface method. The optimal parameters of the enrichment process were a sample concentration of 0.3 mg/mL, a loading rate of 1 mL/min, an elution flow rate of 2 mL/min, and a total flavonoid content of 155.38 ± 0.97 mg/g. The flavonoids enriched by AB-8 macroporous resin demonstrated significant scavenging activities against DPPH, ABTS+, and hydroxyl free radicals, and also exhibited certain inhibitory effects on α-amylase and α-glucosidase. Among them, the scavenging ability of the flavonoids enriched by AB-8 macroporous resin on hydroxyl free radical (IC50 = 30.31 ± 1.92 μg/mL) was the closest to Vc, and the inhibitory effect on α-glucosidase (IC50 = 16.19 ± 1.35 μg/mL) was the best. These findings confirmed the potential of Artemisia Selengensis Turcz. is a natural antioxidant and hypoglycemic drug.

利用大孔树脂富集塞伦蒿乙酸乙酯提取物中的黄酮类化合物。在单因素实验的基础上,采用响应面法对富集过程进行了优化。富集过程的最佳参数为:样品浓度为0.3 mg/mL,上样速率为1 mL/min,洗脱流速为2 mL/min,总黄酮含量为155.38 ± 0.97 mg/g。AB-8大孔树脂富集的黄酮类化合物对DPPH、ABTS+和羟基自由基有显著的清除活性,对α-淀粉酶和α-葡萄糖苷酶也有一定的抑制作用。其中,AB-8 大孔树脂富集的黄酮类化合物对羟自由基的清除能力(IC50 = 30.31 ± 1.92 μg/mL)与 Vc 最接近,对α-葡萄糖苷酶的抑制作用(IC50 = 16.19 ± 1.35 μg/mL)最好。这些发现证实了茵陈蒿作为天然抗氧化剂和降血糖药物的潜力。
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引用次数: 0
Three New Sesquiterpenes from the Leaves of Aglaia elaeagnoidea with NO Inhibitory Activity. 具有氮氧化物抑制活性的 Aglaia elaeagnoidea 叶中的三种新的倍半萜。
IF 2.3 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-10 DOI: 10.1002/cbdv.202402159
Nguyen Huy Hoang, Do Thi Trang, Ngo Anh Bang, Pham Hai Yen, Duong Thi Dung, Nguyen Xuan Nhiem, Le Thi Huyen, Phan Thi Thanh Huong, Duong Thi Hai Yen, Bui Huu Tai, Phan Van Kiem

Aglanoideas A-C (1-3), three undescribed sesquiterpenes and eleven known compounds (4-14) were isolated from the leaves of Aglaia elaeagnoidea. Their structures including absolute configurations were characterized by using IR, HR-ESI-MS, NMR, and experimental and calculating ECD methods. Compounds 3-5, and 7 showed moderate nitric oxide inhibitory activity with IC50 values ranging from 53.7 to 72.5 μM.

从 Aglaia elaeagnoidea 的叶子中分离出了 Aglanoideas A-C(1-3)、三种未被描述的倍半萜和十一种已知化合物(4-14)。利用红外光谱、HR-ESI-MS、核磁共振以及实验和计算 ECD 的方法对这些化合物的结构(包括绝对构型)进行了表征。化合物 3-5 和 7 显示出中等程度的一氧化氮抑制活性,IC50 值在 53.7 至 72.5 µM 之间。
{"title":"Three New Sesquiterpenes from the Leaves of Aglaia elaeagnoidea with NO Inhibitory Activity.","authors":"Nguyen Huy Hoang, Do Thi Trang, Ngo Anh Bang, Pham Hai Yen, Duong Thi Dung, Nguyen Xuan Nhiem, Le Thi Huyen, Phan Thi Thanh Huong, Duong Thi Hai Yen, Bui Huu Tai, Phan Van Kiem","doi":"10.1002/cbdv.202402159","DOIUrl":"10.1002/cbdv.202402159","url":null,"abstract":"<p><p>Aglanoideas A-C (1-3), three undescribed sesquiterpenes and eleven known compounds (4-14) were isolated from the leaves of Aglaia elaeagnoidea. Their structures including absolute configurations were characterized by using IR, HR-ESI-MS, NMR, and experimental and calculating ECD methods. Compounds 3-5, and 7 showed moderate nitric oxide inhibitory activity with IC<sub>50</sub> values ranging from 53.7 to 72.5 μM.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":" ","pages":"e202402159"},"PeriodicalIF":2.3,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design And Synthesis Of Novel Thiazole Linked Tetrahydropyridine Analogues As Anticancer Agents. 设计和合成新型噻唑类四氢吡啶类似物作为抗癌剂
IF 2.3 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-11-10 DOI: 10.1002/cbdv.202402223
Ram Mohan Malothu, Gangadhar Thalari

A library of new thiazole linked tetrahydropyridines (6a-q) synthesized and screened for their invitro anticancer activity against human breast adeno carcinoma cell viz. MCF-7 and MDA-MB-231. The two compounds 6d containing -F and -Cl functions in para and meta position of phenyl ring (9.94 ± 1.02µM, 9.78 ± 1.08µM) and 6e with -Cl and -NH2 functions on pyridine ring (9.72 ± 0.91 µM,9.54 ± 0.95µM) demonstrated outstanding activity against both the cell lines when compared to Doxorubicin. The benzofuran analogue 6o presented good activity with an IC50 value of 12.19 ± 1.03µM (MCF-7) and 12.22 ± 1.07µM (MDA-MB-231). The molecular docking study of potent molecule 6e against crystal structure of breast tumor kinase presented promising docking score and binding interactions. Predicted pharmacokinetics properties of compounds 6a-q and presented boiled diagram of compounds 6d and 6e implied favourable drug-likeness properties.

合成了一个新的噻唑连接四氢吡啶化合物库(6a-q),并筛选了它们对人类乳腺腺癌细胞 MCF-7 和 MDA-MB-231 的体外抗癌活性。与多柔比星相比,苯并呋喃类似物 6d(9.94 ± 1.02µM,9.78 ± 1.08µM)和 6e(9.72 ± 0.91 µM,9.54 ± 0.95µM)在苯环的对位和偏位上含有-F 和-Cl 功能,对这两种细胞株都具有出色的活性。苯并呋喃类似物 6o 具有良好的活性,其 IC50 值分别为 12.19 ± 1.03µM (MCF-7)和 12.22 ± 1.07µM (MDA-MB-231)。根据乳腺肿瘤激酶的晶体结构对强效分子 6e 进行的分子对接研究显示,其对接得分和结合相互作用前景良好。6a-q 化合物的药代动力学特性预测以及 6d 和 6e 化合物的沸腾图显示了良好的药物亲和性。
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引用次数: 0
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