Pub Date : 2019-03-20DOI: 10.3760/CMA.J.ISSN.0254-1785.2019.03.006
Wenyi Guo, Weijie Cao, Xinsheng Xie, R. Guo, Suping Zhang, Li Li, Ran Yan
Objective To analyze the clinical significance of early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in acute myeloid leukemia. Methods The clinical data of 89 patients with acute myeloid leukemia undergoing allo-HSCT were retrospectively analyzed. The absolute lymphocyte count at Day 21 (ALC21) after allo-HSCT was used for representing the recovery rate of lymphocyte. And the effects of ALC21 on disease relapse, overall survival (OS), disease-free survival (DFS) and other parameters were analyzed. Results The recurrent rate of ALC21 ≥0.5×109/L group (high ALC21 group) was significantly lower than that of ALC21 <0.5×109/L group (low ALC21 group)(19.6 % vs 48.5 %, P=0.004). The 2-year OS and DFS of high ALC21 group spiked markedly as compared with low ALC21 group [(74.0±6.0 % vs (46.5±9.5) %, P=0.002], [(70.5±6.2) % vs (44.9±9.3) %, P=0.009] while viral infection rate declined markedly (37.5 % vs 60.6 %, P=0.035). However, non-recurrence mortality (NRM), acute graft-versus-host disease (aGVHD) and chronic graft-versus-host disease (cGVHD) (P=0.556) were not elevated in high ALC21 group as compared with low ALC21 group (P=0.584, P=0.08, P=0.556). Conclusions Early lymphocyte recovery after in acute myeloid leukemia patients has significant early predictive value for recurrence and long-term prognosis after allo-HSCT. Key words: Allogeneic hematopoietic stem cell transplantation; Acute leukemia; lymphocyte
目的分析急性髓系白血病同种异体造血干细胞移植(allogeneic hematopoietic stem cell transplantation, alloo - hsct)术后早期淋巴细胞恢复的临床意义。方法回顾性分析89例急性髓系白血病行同种异体造血干细胞移植的临床资料。用同种异体造血干细胞移植后第21天的绝对淋巴细胞计数(ALC21)代表淋巴细胞的恢复率。分析ALC21对疾病复发、总生存期(OS)、无病生存期(DFS)等参数的影响。结果ALC21≥0.5×109/L组(高ALC21组)复发率显著低于ALC21 <0.5×109/L组(低ALC21组)(19.6% vs 48.5%， P=0.004)。ALC21高组2年OS和DFS明显高于ALC21低组[(74.0±6.0% vs(46.5±9.5)%，P=0.002]，[(70.5±6.2)% vs(44.9±9.3)%，P=0.009]，病毒感染率明显下降(37.5% vs 60.6%， P=0.035)。与低ALC21组相比，高ALC21组的非复发死亡率(NRM)、急性移植物抗宿主病(aGVHD)和慢性移植物抗宿主病(cGVHD) (P=0.556)均未升高(P=0.584, P=0.08, P=0.556)。结论急性髓系白血病患者术后早期淋巴细胞恢复对同种异体造血干细胞移植术后复发及远期预后具有重要的早期预测价值。关键词:异基因造血干细胞移植;急性白血病;淋巴细胞
{"title":"Clinical prognostic significance of early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia","authors":"Wenyi Guo, Weijie Cao, Xinsheng Xie, R. Guo, Suping Zhang, Li Li, Ran Yan","doi":"10.3760/CMA.J.ISSN.0254-1785.2019.03.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2019.03.006","url":null,"abstract":"Objective \u0000To analyze the clinical significance of early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in acute myeloid leukemia. \u0000 \u0000 \u0000Methods \u0000The clinical data of 89 patients with acute myeloid leukemia undergoing allo-HSCT were retrospectively analyzed. The absolute lymphocyte count at Day 21 (ALC21) after allo-HSCT was used for representing the recovery rate of lymphocyte. And the effects of ALC21 on disease relapse, overall survival (OS), disease-free survival (DFS) and other parameters were analyzed. \u0000 \u0000 \u0000Results \u0000The recurrent rate of ALC21 ≥0.5×109/L group (high ALC21 group) was significantly lower than that of ALC21 <0.5×109/L group (low ALC21 group)(19.6 % vs 48.5 %, P=0.004). The 2-year OS and DFS of high ALC21 group spiked markedly as compared with low ALC21 group [(74.0±6.0 % vs (46.5±9.5) %, P=0.002], [(70.5±6.2) % vs (44.9±9.3) %, P=0.009] while viral infection rate declined markedly (37.5 % vs 60.6 %, P=0.035). However, non-recurrence mortality (NRM), acute graft-versus-host disease (aGVHD) and chronic graft-versus-host disease (cGVHD) (P=0.556) were not elevated in high ALC21 group as compared with low ALC21 group (P=0.584, P=0.08, P=0.556). \u0000 \u0000 \u0000Conclusions \u0000Early lymphocyte recovery after in acute myeloid leukemia patients has significant early predictive value for recurrence and long-term prognosis after allo-HSCT. \u0000 \u0000 \u0000Key words: \u0000Allogeneic hematopoietic stem cell transplantation; Acute leukemia; lymphocyte","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":"107 1","pages":"148-152"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89981887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Monitoring of complications related to allogeneic hematopoietic stem cell transplantation","authors":"Yu Hu","doi":"10.3760/CMA.J.ISSN.0254-1785.2019.03.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2019.03.001","url":null,"abstract":"异基因造血干细胞移植是治愈许多血液病的最佳选择。对于成人Ph样急性淋巴细胞白血病，采用综合治疗序贯移植成功治疗4例患者。移植相关并发症的监测一直是临床难题，通过对98例重型再生障碍性贫血患者回顾性研究，发现铁过载导致造血重建明显延迟。免疫重建是移植成功的关键环节，研究发现淋巴细胞的快速恢复，可明显提高移植存活率，降低病毒感染率。复发是移植后最严重的并发症，研究发现脑脊液嵌合度监测可有效预测中枢神经系统复发，受者嵌合率升高可作为早期干预指征。","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":"114 1","pages":"129-130"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79224652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-20DOI: 10.3760/CMA.J.ISSN.0254-1785.2019.03.003
Yuanyuan Shi, Sudong Zhang, Gui-xin Zhang, W. Zhai, Yi He, Rong-li Zhang, Qiao-ling Ma, A. Pang, Donglin Yang, Jialin Wei, Yong Huang, E. Jiang, Mingzhe Han
Objective To explore the effect of iron overload on the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients with non-hepatitis related severe aplastic anemia (SAA). Methods The clinical data were retrospectively analyzed for 98 patients with non-hepatitis related SAA undergoing allo-HSCT from July 2012 to late July 2018 at a single center. Serum ferritin (SF) was measured within 2 months before HSCT. They were divided into iron overload (SF>800.0 ng/ml, n=49) and control (SF<800.0 ng/ml, n=49) groups according to SF level. Overall survival (OS), hematopoietic reconstitution and common complications after allo-HSCT were analyzed. Results The median pre-transplantation SF value was 798.7(52.0-11060.0l) ng/ml. Patients with pre-transplantation iron overload had a higher incidence of cytomegaloviremia (P=0.041), delayed recovery of neutrophil/platelet (P=0.001, P=0.005 respectively) and transfusion-dependence in donor-recipient blood group-matched patients (P=0.043) after allo-HSCT. The 3-year OS was (65.1±7.1) % in iron overload group and (93.3±3.7) % in control group (P=0.001). Multivariate analysis indicated that 3-year OS was independently correlated with pre-transplantation iron overload (P=0.022), blood group of donor & recipient (P=0.015), early bacteremia (P=0.003) and cytomegaloviremia (P=0.003). Conclusions Iron overload is common in patients with non-hepatitis-related SAA before transplantation. Pre-transplantation iron overload has a significant impact on OS, hematopoietic reconstitution and cytomegaloviremia after allo-HSCT. Key words: Allogeneic hematopoietic stem cell transplantation; Ferritin; Aplastic anemia; Survival rate
{"title":"Effect of pre-transplantation iron overload on the outcomes of allogeneic hematopoietic stem cell transplantation patients with non-hepatitis-related severe aplastic anemia","authors":"Yuanyuan Shi, Sudong Zhang, Gui-xin Zhang, W. Zhai, Yi He, Rong-li Zhang, Qiao-ling Ma, A. Pang, Donglin Yang, Jialin Wei, Yong Huang, E. Jiang, Mingzhe Han","doi":"10.3760/CMA.J.ISSN.0254-1785.2019.03.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2019.03.003","url":null,"abstract":"Objective \u0000To explore the effect of iron overload on the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients with non-hepatitis related severe aplastic anemia (SAA). \u0000 \u0000 \u0000Methods \u0000The clinical data were retrospectively analyzed for 98 patients with non-hepatitis related SAA undergoing allo-HSCT from July 2012 to late July 2018 at a single center. Serum ferritin (SF) was measured within 2 months before HSCT. They were divided into iron overload (SF>800.0 ng/ml, n=49) and control (SF<800.0 ng/ml, n=49) groups according to SF level. Overall survival (OS), hematopoietic reconstitution and common complications after allo-HSCT were analyzed. \u0000 \u0000 \u0000Results \u0000The median pre-transplantation SF value was 798.7(52.0-11060.0l) ng/ml. Patients with pre-transplantation iron overload had a higher incidence of cytomegaloviremia (P=0.041), delayed recovery of neutrophil/platelet (P=0.001, P=0.005 respectively) and transfusion-dependence in donor-recipient blood group-matched patients (P=0.043) after allo-HSCT. The 3-year OS was (65.1±7.1) % in iron overload group and (93.3±3.7) % in control group (P=0.001). Multivariate analysis indicated that 3-year OS was independently correlated with pre-transplantation iron overload (P=0.022), blood group of donor & recipient (P=0.015), early bacteremia (P=0.003) and cytomegaloviremia (P=0.003). \u0000 \u0000 \u0000Conclusions \u0000Iron overload is common in patients with non-hepatitis-related SAA before transplantation. Pre-transplantation iron overload has a significant impact on OS, hematopoietic reconstitution and cytomegaloviremia after allo-HSCT. \u0000 \u0000 \u0000Key words: \u0000Allogeneic hematopoietic stem cell transplantation; Ferritin; Aplastic anemia; Survival rate","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":"131 1","pages":"133-137"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87954136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Promote innovative development of liver transplantation of China in big data era","authors":"Xuyong Wei, Xiao Xu","doi":"10.3760/CMA.J.ISSN.0254-1785.2019.03.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2019.03.002","url":null,"abstract":"半个世纪以来，我国肝移植事业取得了令人瞩目的进步，但仍存在诸多瓶颈难题。精准医学和大数据时代下的肝移植研究，应加强临床重大需求为驱动的引领性多中心临床研究，并善于从临床诊治实践中不断总结和凝练新的科学问题，推进科研持续创新发展。进一步以多学科融合研究为孵化器，打造一支年富力强的中青年肝移植临床骨干和医师科学家队伍，涌现一批具有国际影响力的原创性科研成果，推动我国肝移植从世界大国向强国迈进。","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":"11 suppl_1 1","pages":"131-132"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75757606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-20DOI: 10.3760/CMA.J.ISSN.0254-1785.2019.03.012
Jingyao Li, Z. Chu, Wenjuan Yu, Mingyang Li, T. Ren, Qian Ji
Objective To quantitatively evaluate the diagnostic value of blood oxygen level-dependent (BOLD) MRI in the diagnosis of different degrees of liver warm ischemia-reperfusion injury (WIRI) in rabbits and evaluate the intervention effect of liposomal prostaglandin E1 (Lipo-PGE1) . Methods Seventy healthy adult New Zealand white rabbits were randomly divided into sham-operated group (A0), thermal ischemic groups (A1~A3) and intervention groups (A4~A6). All experimental rabbits were scanned by routine MR and BOLD MRI after 6-hour reperfusion. R2* images were calculated by two radiologists. The levels of alanine aminotransferase (ALT), asparate aminotransferase (AST) and lactate dehydrogenase (LDH) were examined. And liver pathological sectioning was performed. All data were processed by one-way, Spearman’s correlation and receiver operating characteristic curve analyses. Results The intraclass correlation coefficient (ICC) was 0.805 of two measurements suggesting that the repeatability of the outcome was decent. R2* values among sham-operated, thermal ischemia and intervention groups were statistically significant (P 0.5, P<0.05). ROC analysis indicated that R2* had an excellent diagnostic performance. Conclusions BOLD MRI may be applied for noninvasive assessment of liver ischemia-reperfusion injury in different degrees. Lipo-PGE1 alleviates ischemia-reperfusion injury and BOLD MRI can evaluate the relieving degree of Lipo-PGE1. Key words: Magnetic resonance imaging; Liver; ischemia-chemia reperfusion injury
{"title":"Using blood oxygen level dependent (BOLD) MRI in the diagnosis of hepatic warm ischemia-reperfusion injury in rabbits and evaluation of liposomal prostaglandin E1 intervention effect","authors":"Jingyao Li, Z. Chu, Wenjuan Yu, Mingyang Li, T. Ren, Qian Ji","doi":"10.3760/CMA.J.ISSN.0254-1785.2019.03.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2019.03.012","url":null,"abstract":"Objective \u0000To quantitatively evaluate the diagnostic value of blood oxygen level-dependent (BOLD) MRI in the diagnosis of different degrees of liver warm ischemia-reperfusion injury (WIRI) in rabbits and evaluate the intervention effect of liposomal prostaglandin E1 (Lipo-PGE1) . \u0000 \u0000 \u0000Methods \u0000Seventy healthy adult New Zealand white rabbits were randomly divided into sham-operated group (A0), thermal ischemic groups (A1~A3) and intervention groups (A4~A6). All experimental rabbits were scanned by routine MR and BOLD MRI after 6-hour reperfusion. R2* images were calculated by two radiologists. The levels of alanine aminotransferase (ALT), asparate aminotransferase (AST) and lactate dehydrogenase (LDH) were examined. And liver pathological sectioning was performed. All data were processed by one-way, Spearman’s correlation and receiver operating characteristic curve analyses. \u0000 \u0000 \u0000Results \u0000The intraclass correlation coefficient (ICC) was 0.805 of two measurements suggesting that the repeatability of the outcome was decent. R2* values among sham-operated, thermal ischemia and intervention groups were statistically significant (P 0.5, P<0.05). ROC analysis indicated that R2* had an excellent diagnostic performance. \u0000 \u0000 \u0000Conclusions \u0000BOLD MRI may be applied for noninvasive assessment of liver ischemia-reperfusion injury in different degrees. Lipo-PGE1 alleviates ischemia-reperfusion injury and BOLD MRI can evaluate the relieving degree of Lipo-PGE1. \u0000 \u0000 \u0000Key words: \u0000Magnetic resonance imaging; Liver; ischemia-chemia reperfusion injury","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":"64 1","pages":"175-178"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73863265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To explore the efficacy of hematopoietic stem cell transplantation (HSCT) for 5 patients with Ph-like acute lymphoblastic leukemia (ALL). Methods Fluorescent in situ hybridization (FISH) was performed for detecting the rearrangement of susceptibility genes. Combined therapy of chemotherapy and ruxolitinib were applied, followed by HSCT. Those failing to achieve complete remission (CR) received an infusion of chimeric antigen T-cells (CAR-T), followed by HSCT once CR was achieved. Four patients accept allogenic HSCT while another auto HSCT. Results Three of them achieved CR after chemotherapy and ruxolitinib. The remaining 2 patients got CR after CAR-T. Four patients remained in CR after HSCT. Early relapse occurred in 1 patient after HSCT. Conclusions Combined therapy of chemotherapy, ruxolitinib and CAR-T are necessary for Ph-like ALL patients. HSCT after an initial CR improve patient prognosis. Key words: Heamatopoietic stem cell transplantation; Lymphoblastic leukemia; Acute
{"title":"Hematopoietic stem cell transplantation for Ph-like acute lymphoblastic leukemia and literature review","authors":"Hai-ping Dai, Zheng Li, Jia Yin, Minghong Liu, Xiaming Zhu, Depei Wu","doi":"10.3760/CMA.J.ISSN.0254-1785.2019.03.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2019.03.005","url":null,"abstract":"Objective \u0000To explore the efficacy of hematopoietic stem cell transplantation (HSCT) for 5 patients with Ph-like acute lymphoblastic leukemia (ALL). \u0000 \u0000 \u0000Methods \u0000Fluorescent in situ hybridization (FISH) was performed for detecting the rearrangement of susceptibility genes. Combined therapy of chemotherapy and ruxolitinib were applied, followed by HSCT. Those failing to achieve complete remission (CR) received an infusion of chimeric antigen T-cells (CAR-T), followed by HSCT once CR was achieved. Four patients accept allogenic HSCT while another auto HSCT. \u0000 \u0000 \u0000Results \u0000Three of them achieved CR after chemotherapy and ruxolitinib. The remaining 2 patients got CR after CAR-T. Four patients remained in CR after HSCT. Early relapse occurred in 1 patient after HSCT. \u0000 \u0000 \u0000Conclusions \u0000Combined therapy of chemotherapy, ruxolitinib and CAR-T are necessary for Ph-like ALL patients. HSCT after an initial CR improve patient prognosis. \u0000 \u0000 \u0000Key words: \u0000Heamatopoietic stem cell transplantation; Lymphoblastic leukemia; Acute","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":"1 1","pages":"144-147"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79007296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-20DOI: 10.3760/CMA.J.ISSN.0254-1785.2019.03.011
B. Wei, Zhenglu Wang, Wen Hou, Yuan Shi, Dai-Hong Li, Hong Zheng
Objective To explore the changes and significance of hepatic cytokines during ischemia and reperfusion in rats undergoing donation after circulatory death (DCD) liver transplantation in different functional warm ischemic durations. Methods Maastricht Ⅲ DCD liver transplantation was simulated and a rat model of functional warm ischemia established. DCD liver transplantation was established by cutting diaphragm. There were four groups of functional warm ischemia 0/15/30 min and living donor liver transplantation control. Liver tissues and serum samples were obtained after donor liver acquisition and 6-hour reperfusion respectively. Luminex liquid chip was employed for detecting the concentrations of 23 cytokines in liver tissue, superoxide dismutase or malondialdehyde (SOD/MDA) expression in liver tissue and alanine transaminase or aspartate aminotransferase (ALT/AST) expression in sera. And hematoxylin-eosin (HE) staining was utilized for detecting liver tissue damage. Results The levels of cytokines in liver tissues during ischemia and reperfusion were significantly different in different functional warm ischemic durations. SOD/MDA in liver tissue, AST/ALT in sera and pathological examinations also showed that, with the prolongation of functional warm ischemic duration, the degree of liver tissue injury gradually aggravated. Conclusions Functional warm ischemic duration has a significant effect on cytokines during ischemia and reperfusion in rat DCD liver transplantation. This phenomenon can help us further elucidate the mechanism of ischemia-reperfusion injury and provide new ideas for preventing ischemia-reperfusion injury during DCD liver transplantation. Key words: Liver transplantation; Ischemia reperfusion; Cytokine
{"title":"Changes of inflammatory cytokines in rat liver transplantation model under different functional warm ischemic durations","authors":"B. Wei, Zhenglu Wang, Wen Hou, Yuan Shi, Dai-Hong Li, Hong Zheng","doi":"10.3760/CMA.J.ISSN.0254-1785.2019.03.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2019.03.011","url":null,"abstract":"Objective \u0000To explore the changes and significance of hepatic cytokines during ischemia and reperfusion in rats undergoing donation after circulatory death (DCD) liver transplantation in different functional warm ischemic durations. \u0000 \u0000 \u0000Methods \u0000Maastricht Ⅲ DCD liver transplantation was simulated and a rat model of functional warm ischemia established. DCD liver transplantation was established by cutting diaphragm. There were four groups of functional warm ischemia 0/15/30 min and living donor liver transplantation control. Liver tissues and serum samples were obtained after donor liver acquisition and 6-hour reperfusion respectively. Luminex liquid chip was employed for detecting the concentrations of 23 cytokines in liver tissue, superoxide dismutase or malondialdehyde (SOD/MDA) expression in liver tissue and alanine transaminase or aspartate aminotransferase (ALT/AST) expression in sera. And hematoxylin-eosin (HE) staining was utilized for detecting liver tissue damage. \u0000 \u0000 \u0000Results \u0000The levels of cytokines in liver tissues during ischemia and reperfusion were significantly different in different functional warm ischemic durations. SOD/MDA in liver tissue, AST/ALT in sera and pathological examinations also showed that, with the prolongation of functional warm ischemic duration, the degree of liver tissue injury gradually aggravated. \u0000 \u0000 \u0000Conclusions \u0000Functional warm ischemic duration has a significant effect on cytokines during ischemia and reperfusion in rat DCD liver transplantation. This phenomenon can help us further elucidate the mechanism of ischemia-reperfusion injury and provide new ideas for preventing ischemia-reperfusion injury during DCD liver transplantation. \u0000 \u0000 \u0000Key words: \u0000Liver transplantation; Ischemia reperfusion; Cytokine","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":"51 1","pages":"170-174"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78174693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-20DOI: 10.3760/CMA.J.ISSN.0254-1785.2019.03.010
Hongxia Li, Y. Weng, Wenli Yu
Objective To evaluate the effect of propofol and sevoflurane on acute kidney function in infants undergoing pediatric parent liver transplantation. Methods 80 pediatric patients scheduled for pediatric liver transplantation were randomly assigned to receive either continuous infusion of propofol or inhalation of sevoflurane. Serum creatinine (Scr), inflammatory medium and renal biomarkers were measured before surgery (T1), 30min after anhepatic phase (T2), 3h after ischemia reperfusion (T3), 36 h after surgery(T4) to evaluate the effect of anesthetics on the development of postoperative kidney injury. Results Overall, compared Propofol group, the mean arterial pressure changed slightly in sevoflurane group. The inflammatory factors of Scr, IL-18, TNF-α, and levels of NGAL were lower in sevoflurane group while no differences of IL-10 were found between both groups. Conclusions Compared with propofol anesthesia, the degree of renal injury in pediatric living donor liver transplantion under sevoflurane anesthesia is reduced, which may be related to hemodynamic stability and decreased release of inflammatory factors. Key words: Pediatric liver transplantation; Sevoflurane; Acute kidney injury
目的探讨异丙酚和七氟醚对小儿父母肝移植术后患儿急性肾功能的影响。方法80例小儿肝移植患者随机分为连续输注异丙酚组和吸入七氟醚组。分别于术前(T1)、无肝期后30min (T2)、缺血再灌注后3h (T3)、术后36 h (T4)测定血清肌酐(Scr)、炎症介质及肾脏生物标志物，评价麻醉药物对术后肾损伤发展的影响。结果与异丙酚组比较，七氟醚组平均动脉压变化不大。七氟醚组炎症因子Scr、IL-18、TNF-α及NGAL水平均降低，IL-10水平无显著差异。结论与异丙酚麻醉相比，七氟醚麻醉下儿童活体肝移植肾损伤程度减轻，这可能与血流动力学稳定、炎症因子释放减少有关。关键词:小儿肝移植;七氟醚;急性肾损伤
{"title":"Effects of sevoflurame combined anesthsia on kidney function in pediatric living donor liver transplantation","authors":"Hongxia Li, Y. Weng, Wenli Yu","doi":"10.3760/CMA.J.ISSN.0254-1785.2019.03.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2019.03.010","url":null,"abstract":"Objective \u0000To evaluate the effect of propofol and sevoflurane on acute kidney function in infants undergoing pediatric parent liver transplantation. \u0000 \u0000 \u0000Methods \u000080 pediatric patients scheduled for pediatric liver transplantation were randomly assigned to receive either continuous infusion of propofol or inhalation of sevoflurane. Serum creatinine (Scr), inflammatory medium and renal biomarkers were measured before surgery (T1), 30min after anhepatic phase (T2), 3h after ischemia reperfusion (T3), 36 h after surgery(T4) to evaluate the effect of anesthetics on the development of postoperative kidney injury. \u0000 \u0000 \u0000Results \u0000Overall, compared Propofol group, the mean arterial pressure changed slightly in sevoflurane group. The inflammatory factors of Scr, IL-18, TNF-α, and levels of NGAL were lower in sevoflurane group while no differences of IL-10 were found between both groups. \u0000 \u0000 \u0000Conclusions \u0000Compared with propofol anesthesia, the degree of renal injury in pediatric living donor liver transplantion under sevoflurane anesthesia is reduced, which may be related to hemodynamic stability and decreased release of inflammatory factors. \u0000 \u0000 \u0000Key words: \u0000Pediatric liver transplantation; Sevoflurane; Acute kidney injury","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":"40 1","pages":"166-169"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79995939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-20DOI: 10.3760/CMA.J.ISSN.0254-1785.2019.03.008
Jiajia Jiang, Q. Fu, Sizhe Long, Huanxi Zhang, Xiaojun Su, Jun Li, Chenglin Wu, R. Deng, Longshan Liu, Wujun Zhang, Changxi Wang
Objective To assess the efficacy and safety of febuxostat in the treatment of hyperuricemia in renal transplant recipients. Methods A total of 124 renal transplant patients with hyperuricemia receiving febuxostat between June 2016 and July 2018 were retrospectively analyzed. Uric acid (UA), liver function and renal function parameters before and 3 months after treatment were compared. Adverse events, recipient and renal allograft survival were recorded throughout the follow-up period. Results Serum level of uric acid significantly decreased after 3-month treatment (P<0.001). And 66.1 % of them achieved target UA level at Month 3 after dosing. Estimated glomerular filtration rate (eGFR) was maintained. No severe adverse event was observed. All recipient and renal grafts survived during the follow-up period. Conclusions Febuxostat is both effective and safe in the treatment of hyperuricemia in renal transplant. Key words: Renal transplantation; Hyperuricemia; Efficacy
{"title":"Efficacy and safety of febuxostat in renal transplant recipients with hyperuricemia","authors":"Jiajia Jiang, Q. Fu, Sizhe Long, Huanxi Zhang, Xiaojun Su, Jun Li, Chenglin Wu, R. Deng, Longshan Liu, Wujun Zhang, Changxi Wang","doi":"10.3760/CMA.J.ISSN.0254-1785.2019.03.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2019.03.008","url":null,"abstract":"Objective \u0000To assess the efficacy and safety of febuxostat in the treatment of hyperuricemia in renal transplant recipients. \u0000 \u0000 \u0000Methods \u0000A total of 124 renal transplant patients with hyperuricemia receiving febuxostat between June 2016 and July 2018 were retrospectively analyzed. Uric acid (UA), liver function and renal function parameters before and 3 months after treatment were compared. Adverse events, recipient and renal allograft survival were recorded throughout the follow-up period. \u0000 \u0000 \u0000Results \u0000Serum level of uric acid significantly decreased after 3-month treatment (P<0.001). And 66.1 % of them achieved target UA level at Month 3 after dosing. Estimated glomerular filtration rate (eGFR) was maintained. No severe adverse event was observed. All recipient and renal grafts survived during the follow-up period. \u0000 \u0000 \u0000Conclusions \u0000Febuxostat is both effective and safe in the treatment of hyperuricemia in renal transplant. \u0000 \u0000 \u0000Key words: \u0000Renal transplantation; Hyperuricemia; Efficacy","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":"38 1","pages":"158-161"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81016031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-20DOI: 10.3760/CMA.J.ISSN.0254-1785.2019.03.009
Juan Li, Huanhuan Wang, Bingjie Tian, Shuyan Yu, Jiajia Zhou, Cong-huan Shen, Zhengxin Wang, Yanpei Cao
Objective To explore the postoperative psychological status of donors during pediatric living donor liver transplantation (LDLT) to elucidate the correlation between resilience, anxiety and depression. Methods Random sampling was employed for selecting 60 pediatric LDLT donors undergoing LDLT from September 2014 to February 2019. They were requested to answer a questionnaire. The questionnaire concluded general information, self-rating anxiety scale (SAS), self-rating depression scale (SDS) and Chinese version of Resilience Scale. Results The score of anxiety was (46.06±10.06) and depression was (50.32±11.49). Both values were higher than those of Chinese norm. The score of resilience was (59.55±14.62). And the total score of resilience and the score of each dimension were negatively correlated with anxiety and depression (P<0.01). Conclusions The postoperative anxiety and depression level of donors during LDLT are higher than the ordinary. Resilience is negatively correlated with the level of anxiety and depression. The lower level of resilience, the higher anxiety and depression of donors during LDLT. For clinicians, appropriate intervention measures should be taken for improving the resilience, reducing negative emotions and boosting the quality-of-life of donors during LDLT. Key words: Liver transplantation; Living donor; Anxiety; Depression; Child
{"title":"Correlation between resilience, anxiety and depression among donors during pediatric living donor liver transplantation","authors":"Juan Li, Huanhuan Wang, Bingjie Tian, Shuyan Yu, Jiajia Zhou, Cong-huan Shen, Zhengxin Wang, Yanpei Cao","doi":"10.3760/CMA.J.ISSN.0254-1785.2019.03.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-1785.2019.03.009","url":null,"abstract":"Objective \u0000To explore the postoperative psychological status of donors during pediatric living donor liver transplantation (LDLT) to elucidate the correlation between resilience, anxiety and depression. \u0000 \u0000 \u0000Methods \u0000Random sampling was employed for selecting 60 pediatric LDLT donors undergoing LDLT from September 2014 to February 2019. They were requested to answer a questionnaire. The questionnaire concluded general information, self-rating anxiety scale (SAS), self-rating depression scale (SDS) and Chinese version of Resilience Scale. \u0000 \u0000 \u0000Results \u0000The score of anxiety was (46.06±10.06) and depression was (50.32±11.49). Both values were higher than those of Chinese norm. The score of resilience was (59.55±14.62). And the total score of resilience and the score of each dimension were negatively correlated with anxiety and depression (P<0.01). \u0000 \u0000 \u0000Conclusions \u0000The postoperative anxiety and depression level of donors during LDLT are higher than the ordinary. Resilience is negatively correlated with the level of anxiety and depression. The lower level of resilience, the higher anxiety and depression of donors during LDLT. For clinicians, appropriate intervention measures should be taken for improving the resilience, reducing negative emotions and boosting the quality-of-life of donors during LDLT. \u0000 \u0000 \u0000Key words: \u0000Liver transplantation; Living donor; Anxiety; Depression; Child","PeriodicalId":9885,"journal":{"name":"Chineae Journal of Organ Transplantation","volume":"83 1","pages":"162-165"},"PeriodicalIF":0.0,"publicationDate":"2019-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75883633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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