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Chitosan-templated copper nanocluster array with reasonable spatial-constraint enabled effective determination of trace fluoroquinolones. 壳聚糖模板铜纳米簇阵列具有合理的空间约束,可以有效地测定痕量氟喹诺酮类药物。
IF 5.3 2区 化学 Q1 CHEMISTRY, ANALYTICAL Pub Date : 2026-02-07 DOI: 10.1007/s00604-026-07898-8
Guangmei Liu, Zeqi Liu, Yu Yang, Yanling Hu, Qingye Liu, Jingli Zhou
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引用次数: 0
4-Phenylbutyrate Induces Functional Elongation of the Microglial Process Through Activation of Akt. 4-苯基丁酸通过激活Akt诱导小胶质细胞过程的功能延伸。
IF 3.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2026-02-07 DOI: 10.1007/s11064-026-04688-9
Tianyi Dai, Qijun Dai, Yueqin Ding, Jianbin Su, Chao Huang, Rongrong Yang, Jie Peng, Zhuo Chen, Rongrong Song, Yunli Fang, Hanxiao Wang, Minxiu Ye, Jianwei Wang, Xu Lu

Conversion of microglia to a branching state is considered a potential strategy to ameliorate neuroinflammation. Inhibition of histone deacetylases (HDACs) may convert microglia to a branching state and thus prevent neuroinflammation. Drugs that inhibit HDACs could be used to alleviate neuroinflammation. Here, we hypothesize that 4-phenylbutyric acid (4-PBA), an HDAC inhibitor, could shift microglia to an anti-inflammatory phenotype by promoting microglial process elongation. As expected, our results showed that 4-PBA induced reversible elongation of branching processes in primary cultured mouse microglia and in microglia in the prefrontal cortex of mice. Pretreatment with 4-PBA also prevented lipopolysaccharide (LPS)-induced shortening of branching processes in microglia under both in vitro and ex vivo conditions, LPS-induced pro-inflammatory responses in cultured microglia and prefrontal cortex, and LPS-induced sickness behavior in mice. Short-term incubation with 4-PBA led to a significant increase in phosphorylation levels of protein kinase B (Akt) in cultured microglia. 4-PBA did not induce microglial process elongation in vitro or ex vivo when cultured microglia or mice were treated with the Akt signaling inhibitor LY294002, suggesting that the pro-elongation effect of 4-PBA on microglial processes require activation of Akt signaling. Moreover, 4-PBA did not prevent LPS-induced inflammatory responses in cultured microglia and prefrontal cortex or LPS-induced sickness behaviors when cultured microglia or mice were treated with LY294002. Altogether, these results indicate that 4-PBA induces microglial process elongation in an Akt-dependent manner, which may underlie the anti-neuroinflammatory properties of 4-PBA.

将小胶质细胞转化为分支状态被认为是改善神经炎症的潜在策略。抑制组蛋白去乙酰化酶(hdac)可以将小胶质细胞转化为分支状态,从而预防神经炎症。抑制hdac的药物可用于缓解神经炎症。在这里,我们假设4-苯基丁酸(4-PBA),一种HDAC抑制剂,可以通过促进小胶质细胞过程伸长将小胶质细胞转变为抗炎表型。正如预期的那样,我们的研究结果表明,4-PBA诱导原代培养小鼠小胶质细胞和小鼠前额皮质小胶质细胞分支过程的可逆伸长。在体外和离体条件下,4-PBA预处理还可以阻止脂多糖(LPS)诱导的小胶质细胞分支过程缩短,LPS诱导的培养小胶质细胞和前额叶皮层的促炎反应,以及LPS诱导的小鼠疾病行为。与4-PBA短期孵育导致培养的小胶质细胞中蛋白激酶B (Akt)磷酸化水平显著升高。用Akt信号抑制剂LY294002处理培养的小胶质细胞或小鼠时,4-PBA在体外和离体均未诱导小胶质过程伸长,提示4-PBA对小胶质过程的促伸长作用需要激活Akt信号。此外,当培养的小胶质细胞或小鼠接受LY294002治疗时,4-PBA并没有阻止lps诱导的小胶质细胞和前额皮质炎症反应或lps诱导的疾病行为。总之,这些结果表明,4-PBA以akt依赖的方式诱导小胶质细胞过程伸长,这可能是4-PBA抗神经炎症特性的基础。
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引用次数: 0
Saponins from cactus and their inhibitory effects on amyloid β aggregation. 仙人掌皂苷及其对淀粉样蛋白β聚集的抑制作用。
IF 2.5 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2026-02-07 DOI: 10.1007/s11418-026-02008-7
Koji Fujihara, Hiroaki Sasaki, Shin Koike, Yuki Ogasawara, Kaoru Kinoshita

Seven new saponins (1-7) isolated from Stenocereus eruca (Cactaceae) and four new saponins (8-11) isolated from Polaskia chichipe (Cactaceae) are described. Their structures were elucidated using high-resolution mass spectrometry and nuclear magnetic resonance analysis including 1H and 13C NMR, DEPT, HMQC, HMBC, H2BC, DQF-COSY, HSQC-TOCSY, phase sensitive TOCSY, 1D-TOCSY, phase sensitive NOESY, and ROESY experiments. One saponin required J-resolved spectroscopy experiments due to its complex 1H NMR spectrum. The inhibitory activity of Aβ aggregation, and protective effects on SH-SY5Y neuroblastoma cells against Aβ toxicity, were evaluated. Only 7 showed weak inhibitory activity of Aβ aggregation at 100 µM compared to the control group. No compounds showed obvious protective effects, but 8 possessed a very weak protective effect on SH-SY5Y cells. The acetylation of the C-16, C-22, and C-30 hydroxyl groups could be important for inhibitory activity of Aβ aggregation and protective effects on SH-SY5Y cells against Aβ toxicity.

报道了从猕猴桃科(仙人掌科)中分离得到的7个新皂苷(1-7)和4个新皂苷(8-11)。通过高分辨率质谱和核磁共振分析,包括1H和13C NMR、DEPT、HMQC、HMBC、H2BC、DQF-COSY、HSQC-TOCSY、相敏TOCSY、1D-TOCSY、相敏NOESY和ROESY实验,对它们的结构进行了鉴定。一种皂苷由于其复杂的1H NMR谱,需要进行j分辨光谱实验。研究了Aβ聚集抑制活性及对SH-SY5Y神经母细胞瘤细胞抗Aβ毒性的保护作用。与对照组相比,只有7个在100µM时表现出较弱的Aβ聚集抑制活性。其中8种化合物对SH-SY5Y细胞的保护作用较弱。C-16、C-22和C-30羟基的乙酰化可能对抑制Aβ聚集活性和对SH-SY5Y细胞抗Aβ毒性的保护作用很重要。
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引用次数: 0
EDTA-induced remobilization of lead from suspended particulate matter in contaminated water samples from the Innerste River: a statistical evaluation. edta诱导的内斯特河污染水样中悬浮颗粒物中铅的再活化:一项统计评估。
IF 5.8 3区 环境科学与生态学 0 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1007/s11356-026-37480-x
Jan Klaus Hinrichs, Markus Herrmann, Aaron Bauer, Dieter Steffen

Ethylenediaminetetraacetic acid (EDTA), extensively used across multiple industries, has long been discussed for its potential to enhance heavy metal mobility in aquatic systems, with studies yielding contradictory results. This study examines the remobilization of particle-bound lead from suspended particulate matter (SPM) in the Innerste River (Lower Saxony, Germany), which is affected by historical mining and known for substantial Pb contamination. Using real river water containing its native SPM to preserve the chemical matrix of the system, we assessed Pb partitioning between total and dissolved phases to evaluate EDTA's remobilization potential. Baseline dissolved lead concentrations reached up to 1.8 µg L-1 (median 0.69 µg L-1). Across all batch experiments, a measurable increase in the dissolved Pb fraction occurred only at EDTA concentrations far exceeding those measured in the river (0.68-3.8 µg L-1). Bayesian concentration-response modelling yielded no-effect concentrations (NEC) between 210 and 530 µg L-1. Complementary speciation modelling showed that shifts in Pb speciation occur only at EDTA concentrations near the experimentally derived NEC values. These findings show that current EDTA concentrations in the Innerste are unlikely to remobilize Pb from SPM. The study also provides a statistically supported NEC estimate based on batch experiments using unaltered river water containing its naturally present SPM. To our knowledge, this is the first application of Bayesian NEC modelling to EDTA-induced Pb remobilization.

乙二胺四乙酸(EDTA)广泛应用于多个行业,长期以来一直因其增强水生系统中重金属流动性的潜力而受到讨论,研究结果相互矛盾。本研究考察了德国下萨克森州内斯特河中悬浮颗粒物(SPM)中颗粒结合铅的再活化,该河流受到历史采矿的影响,并以大量的铅污染而闻名。利用含有天然SPM的真实河水来保存系统的化学基质,我们评估了Pb在总相和溶解相之间的分配,以评估EDTA的再活化潜力。基线溶解铅浓度高达1.8µg L-1(中位数为0.69µg L-1)。在所有的批量实验中,只有在EDTA浓度远远超过河流中测量的浓度(0.68-3.8µg L-1)时,才会出现可测量的溶解Pb分数的增加。贝叶斯浓度-响应模型得出210至530µg L-1之间的无效应浓度(NEC)。互补物种形成模型显示,Pb物种形成的变化只发生在EDTA浓度接近实验得出的NEC值时。这些发现表明,目前内层EDTA浓度不太可能从SPM中重新调动Pb。该研究还提供了一个统计支持的NEC估计基于批量实验使用未改变的河水含有其自然存在的SPM。据我们所知,这是贝叶斯NEC模型首次应用于edta诱导的铅再活化。
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引用次数: 0
Centratherin Exhibits Antitumor Activity Against Glioblastoma Cells. centertherin对胶质母细胞瘤细胞具有抗肿瘤活性。
IF 3.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2026-02-07 DOI: 10.1007/s11064-025-04659-6
Bruna Mafra de Faria, Fernanda Leme da Silva Pinheiro, Isabelle Medeiros, Jonathas F R Lobo, Andrew Magno Teixeira, Leandro Machado Rocha, Ricardo M Borges, Maria Isabel Doria Rossi, Loraine Campanati de Andrade, Bruno Pontes, Luiz Gustavo Dubois, Luciana Ferreira Romão

Glioblastoma (GB) is the most aggressive and lethal primary brain tumor, characterized by high proliferative, migratory, and invasive capacities, as well as marked resistance to apoptosis. Despite standard therapy with temozolomide (TMZ), prognosis remains poor, underscoring the need for novel therapeutic strategies. In this study, we investigated the antitumor potential of centratherin, a sesquiterpene lactone, in established GB cell lines and patient-derived GB cells (GBM02, GBM95). Centratherin significantly reduced cell viability in a dose-dependent manner, with IC50 values varying across GB cells, while exhibiting no cytotoxicity to healthy human astrocytes. Functional assays revealed that centratherin impairs cell proliferation, migration, and invasion, and alters cytoskeletal architecture, as evidenced by morphological changes, reduced actin and tubulin organization. Additionally, centratherin induced double-strand DNA breaks, increased γH2AX levels, and triggered cell death predominantly via necrosis, as demonstrated by LIVE/DEAD staining, Annexin V/PI flow cytometry, and ultrastructural analysis. Notably, this cytotoxic effect did not involve necroptosis, as RIP1 expression and Nec-1 sensitivity were unchanged. Furthermore, centratherin failed to sensitize GB cells to TMZ, suggesting distinct mechanisms of action, in spite of its remarked effect on inducing cell death in GB cancer stem-like cells. Overall, our findings highlight centratherin as a promising selective cytotoxic agent against GB, capable of inducing cell death and disrupting key malignant phenotypes, which may be advantageous for GB treatment.

胶质母细胞瘤(Glioblastoma, GB)是最具侵袭性和致死性的原发性脑肿瘤,具有高增殖、迁移和侵袭能力,并具有明显的细胞凋亡抗性。尽管使用替莫唑胺(TMZ)进行标准治疗,但预后仍然很差,因此需要新的治疗策略。在这项研究中,我们研究了一种倍半萜内酯(centrantherin)在已建立的GB细胞系和患者来源的GB细胞(GBM02, GBM95)中的抗肿瘤潜能。centertherin以剂量依赖的方式显著降低细胞活力,IC50值在GB细胞中不同,而对健康的人类星形胶质细胞没有细胞毒性。功能分析显示,中心霉素损害细胞增殖、迁移和侵袭,并改变细胞骨架结构,如形态学改变、肌动蛋白和微管蛋白组织减少。此外,通过LIVE/DEAD染色、Annexin V/PI流式细胞术和超微结构分析显示,中心花精诱导双链DNA断裂,增加γ - h2ax水平,并主要通过坏死引发细胞死亡。值得注意的是,这种细胞毒性作用不涉及坏死下垂,因为RIP1表达和Nec-1敏感性不变。此外,centertherin未能使GB细胞对TMZ敏感,这表明其作用机制不同,尽管它在诱导GB癌干细胞样细胞死亡方面有明显的作用。总的来说,我们的研究结果突出了中心霉素作为一种有前途的选择性细胞毒性药物,能够诱导细胞死亡并破坏关键的恶性表型,这可能有利于GB的治疗。
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引用次数: 0
Genome Wide Association Study Reveals Novel Loci Controlling Agronomic Traits in Tomato (Solanum lycopersicum L.). 全基因组关联研究揭示番茄(Solanum lycopersicum L.)农艺性状控制新位点。
IF 1.6 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2026-02-07 DOI: 10.1007/s10528-026-11329-x
Jagesh Kumar Tiwari, Nagendra Rai, Manish Kumar Singh, Rajat Singh, Tushar Kant, Suresh Reddy Yerasu, Achuit Kumar Singh, Rajesh Kumar

The genetic basis of agronomic traits is critical for enhancing yield, quality, and disease resistance in tomato. In this study, genome-wide association study (GWAS) was performed on a diverse panel of 72 tomato accessions to identify genomic regions linked to 18 agronomic, processing, and disease resistance traits. Phenotypic data were collected over two growing seasons, and genotyping was conducted using genotyping-by-sequencing (GBS) on the Illumina platform. A total of 78,828 high-quality single nucleotide polymorphisms (SNPs) were identified, primarily located in intergenic (54.66%), upstream (15.46%), downstream (14.35%), intronic (10.73%), and exonic (2.90%) regions. After stringent filtering, 7751 SNPs were retained for GWAS, leading to the identification of 47 significant quantitative trait loci (QTLs) associated with 13 traits. Fruit length exhibited the highest number of QTLs (23), while chromosomes 1 and 4 contained the most QTLs (9 each). Several candidate genes were identified for key traits, including F-box protein CPR1-like and transcription factor bHLH162-like for fruit weight, F-box protein At5g49610 for fruit length, transcription factor TGA9 for fruit diameter, F-box protein CPR1-like and Beta-D-xylosidase 2 for fruit yield, Cinnamoyl-CoA reductase-like SNL6 and UDP-glucosyltransferase, as well as stress-induced protein KIN2-like and serine/threonine-protein kinase BLUS1 for ToLCV resistance. Population structure and phylogenetic analyses indicated variation among ancestral populations (K = 3). These findings provide valuable genomic resources and identify candidate genes for key traits, supporting genomics-driven breeding in tomato.

农艺性状的遗传基础是提高番茄产量、品质和抗病性的关键。在这项研究中,对72个番茄材料进行了全基因组关联研究(GWAS),以确定与18个农艺、加工和抗病性状相关的基因组区域。在两个生长季节收集表型数据,并在Illumina平台上使用基因分型测序(GBS)进行基因分型。共鉴定出78,828个高质量单核苷酸多态性(snp),主要分布在基因间区(54.66%)、上游区(15.46%)、下游区(14.35%)、内含子区(10.73%)和外显子区(2.90%)。经过严格筛选,GWAS保留了7751个snp,鉴定出了与13个性状相关的47个显著数量性状位点(qtl)。果实长度的qtl数量最多(23个),染色体1和4的qtl数量最多(9个)。鉴定出几个关键性状的候选基因,包括决定果实重量的F-box蛋白cpr1样和转录因子bhlh162样,决定果实长度的F-box蛋白At5g49610,决定果实直径的转录因子TGA9,决定果实产量的F-box蛋白cpr1样和β - d -木糖苷酶2,肉桂酰辅酶a还原酶样SNL6和udp -葡萄糖基转移酶,以及决定ToLCV抗性的胁迫诱导蛋白kin2样和丝氨酸/苏氨酸蛋白激酶腼腆1。种群结构和系统发育分析表明祖先种群之间存在差异(K = 3)。这些发现提供了宝贵的基因组资源,并确定了关键性状的候选基因,为基因组驱动的番茄育种提供了支持。
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引用次数: 0
HCG18 is a Potential Pathogenic Factor and Diagnostic Biomarker Alzheimer's Disease. HCG18是阿尔茨海默病的潜在致病因素和诊断性生物标志物。
IF 3.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2026-02-07 DOI: 10.1007/s11064-026-04678-x
Pingting Chen, Genru Li, Lingyan Cheng, Yumei Liu, Yan Liu

Alzheimer's disease (AD), a major neurodegenerative disorder, lacks effective early diagnostic and therapeutic strategies. This study aimed to investigate the diagnostic utility of Long non-coding RNAs HLA Complex Group 18 ( HCG18) in AD and elucidate its molecular mechanisms in neuronal injury. Eighty-three AD patients and 83 healthy controls (HC) were enrolled. Serum samples were analyzed for HCG18 expression using qRT-PCR and cerebrospinal fluid (CSF) samples were analyzed for AD biomarkers by ELISA. Diagnostic performance was assessed using ROC analysis. Aβ1-42-treated HT22 cells (Immortalized murine hippocampal neuronal-like cell line) were employed to model neuronal injury, with HCG18 knockdown and miR-425-3p inhibition experiments conducted to validate functional interactions. HT22 cell apoptosis, oxidative stress markers (SOD, GSH-Px, MDA, ROS), and HCG18/miR-425-3p interactions were evaluated through flow cytometry, biochemical assays, and dual-luciferase reporter systems. Serum HCG18 levels were significantly elevated in AD patients compared to HC (P < 0.001), exhibiting strong diagnostic accuracy (AUC = 0.889). HCG18 expression correlated negatively with CSF Aβ1-42 (r=-0.709) and MMSE scores (r=-0.657), but positively with t-tau (r = 0.591) and p-tau181 (r = 0.582). In Aβ1-42-treated HT22 cells, HCG18 knockdown reduced apoptosis, suppressed ROS, and normalized oxidative stress markers. Mechanistically, HCG18 directly bound to and acted as a molecular sponge for miR-425-3p, sequestering its function; the downregulation of miR-425-3p mediated by a synthetic inhibitor reversed the protective effects of HCG18 silencing. HCG18 serves as a potential non-invasive biomarker for AD, exacerbating neuronal injury via sponging miR-425-3p to disrupt redox balance. Targeting the HCG18/miR-425-3p axis may offer new therapeutic strategies for AD.

阿尔茨海默病(AD)是一种主要的神经退行性疾病,缺乏有效的早期诊断和治疗策略。本研究旨在探讨长链非编码rna HLA Complex Group 18 (HCG18)在AD中的诊断价值,并阐明其在神经元损伤中的分子机制。83例AD患者和83例健康对照(HC)被纳入研究。采用qRT-PCR检测血清中HCG18的表达,ELISA检测脑脊液中AD生物标志物的表达。采用ROC分析评估诊断表现。采用a β1-42处理的HT22细胞(永生化小鼠海马神经元样细胞系)来模拟神经元损伤,通过HCG18敲除和miR-425-3p抑制实验来验证功能相互作用。通过流式细胞术、生化试验和双荧光素酶报告系统评估HT22细胞凋亡、氧化应激标志物(SOD、GSH-Px、MDA、ROS)和HCG18/miR-425-3p相互作用。与HC相比,AD患者血清HCG18水平显著升高(P
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引用次数: 0
In silico pharmacology and 3D-bioprinting reveal Dicranum scoparium as an inhibitor of NF-κB-induced inflammation in the 3D4/31 alveolar macrophage cell line. 硅药理学和3d生物打印显示,在3D4/31肺泡巨噬细胞系中,天竺葵可抑制NF-κ b诱导的炎症。
IF 2.5 4区 医学 Q3 CHEMISTRY, MEDICINAL Pub Date : 2026-02-07 DOI: 10.1007/s11418-025-01997-1
Eun Hye Park, Hyungkuen Kim, Sung-Jo Kim
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引用次数: 0
The social cost of carbon in regions and industries from ESG perspective - a case study of eight economic regions in China. ESG视角下的区域和行业碳排放社会成本——以中国8个经济区域为例
IF 5.8 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1186/s13021-026-00404-w
Zihao Tian, Lixin Tian, Yixiang Zhao

As a core metric for climate policy, the scientific estimation of carbon social costs is crucial for formulating mitigation strategies. However, traditional integrated assessment models predominantly focus on the global aggregate, failing to adequately account for regional heterogeneity, sectoral characteristics, and strategic interactions between regions. They also lack systematic integration of ESG principles. To address this, this paper examines regional and sectoral carbon social costs driven by ESG development. Through cooperative and non-cooperative games, we improve the integrated economic-environmental-climate development model, take the eight economic regions in China as an example, get the carbon social cost of each economic region and typical important industries, and obtain the key parameters and the evolution law of carbon social cost. The model categorizes the carbon emissions after the implementation of emission reduction policies under the ESG perspective into direct and indirect emissions. It studies the economic impacts of the two types of emissions before and after the implementation of emission reduction policies, and conducts research on the top four typical important industries (industry, construction, transportation, and power) that rank among the top four global CO2 emitters, to obtain the analytical solution of the social cost of carbon in the region and the typical important industries. In addition, this paper numerically simulates the social cost of carbon for the four industries under the baseline scenario, cooperative game scenario, non-cooperative game scenario, and temperature limitation scenario. The study shows that the social cost of carbon in the northern, southern and eastern coastal economic regions is higher than that in other economic regions, the social cost of carbon in the industrial and electric power industries in each economic region is higher than that in the building and transportation industries, and the more stringent the temperature limit is, the higher the social cost of carbon is in the economic regions.

作为气候政策的一项核心指标,对碳社会成本的科学估算对于制定缓解战略至关重要。然而,传统的综合评估模型主要关注全球总量,未能充分考虑区域异质性、部门特征和区域间的战略相互作用。它们也缺乏对ESG原则的系统整合。为了解决这个问题,本文研究了ESG发展推动的区域和部门碳社会成本。通过合作与非合作博弈,对经济-环境-气候一体化发展模型进行了改进,并以中国8个经济区为例,得到了各经济区和典型重要产业的碳社会成本,得到了碳社会成本的关键参数和演化规律。该模型将ESG视角下实施减排政策后的碳排放分为直接排放和间接排放。研究了减排政策实施前后两类排放的经济影响,并对全球CO2排放量排名前四的典型重要行业(工业、建筑、交通、电力)进行了研究,得到了该地区及典型重要行业的碳社会成本分析解。此外,本文还对基线情景、合作博弈情景、非合作博弈情景和温度限制情景下四种行业的碳社会成本进行了数值模拟。研究表明,北部、南部和东部沿海经济区域的碳社会成本高于其他经济区域,各经济区域的工业和电力行业的碳社会成本高于建筑和交通行业的碳社会成本,且温度限制越严格,各经济区域的碳社会成本越高。
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引用次数: 0
Investigating the association between PM2.5, Climate variables, and COVID-19 daily reported cases from March 2020 to November 2021 in El Paso County, Texas: A Time-Series Analysis. 调查2020年3月至2021年11月在德克萨斯州埃尔帕索县PM2.5、气候变量和COVID-19每日报告病例之间的关系:时间序列分析。
IF 5.8 3区 环境科学与生态学 0 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-07 DOI: 10.1007/s11356-026-37413-8
Shaila Nazneen, Gabriel Ibarra-Mejia, Soyoung Jeon, Benjamin Ojo, Thomas E Gill, Karin Ardon-Dryer, Kaushik K Pradhan, Joy Leos, Gabriela Herrera

Objective: This study aims to examine the relation between daily maximum exposure to Particulate Matter (PM2.5), high wind speed, and minimum visibility, and COVID-19 cases in El Paso County, Texas, a dust-prone region. A time-series analysis using a generalized linear model with a Poisson model was employed to analyze relative risks of COVID-19 cases in El Paso (March 2020 to November 2021). A total of 156,299 cases were diagnosed during the study period. A 10 μg/m3 increase in PM2.5 levels was linked with higher risk ratio (RR) of COVID-19 (Lag Days 1 to 3) [lag1: RR = 1.004; 95% CI: (1.003-1.005), lag2: RR = 1.006; 95% CI: (1.005-1.007), & lag 3: RR = 1.004; 95% CI: (1.003-1.005)], followed by a decrease in cases. Similarly, a 4.47 m/s rise in maximum wind speed was associated with an elevated RR of cases on Lag Day 4 [lag4: RR = 1.009; 95% CI: (1.003-1.014)], after which numbers begin to drop. Finally, a 4.83 km decrease in minimum daily visibility was correlated with an increased RR of cases on Lag Days 1 and 2 [lag1: RR = 1.031; 95% CI: (1.023-1.039), & lag2: RR = 1.018; 95% CI: (1.011-1.024)], with a decrease on Lag days 3, 4 and 5 and resurgence on Lag days 6 and 7 [lag6: RR = 1.028; 95% CI: (1.021-1.036), & lag7: RR = 1.046; 95% CI: (1.038-1.055)]. PM2.5, wind speed, and visibility influencing COVID-19 cases in El Paso highlight the need for evidence-based interventions, including information, education, and communication programs, early-warning systems, cross-border air-quality management, real-time monitoring, and stricter emission controls.

目的:本研究旨在研究德克萨斯州埃尔帕索县日最大颗粒物(PM2.5)暴露量、高风速和最低能见度与COVID-19病例之间的关系。采用广义线性模型和泊松模型进行时间序列分析,分析了埃尔帕索(2020年3月至2021年11月)COVID-19病例的相对风险。在研究期间,总共诊断了156299例病例。PM2.5水平每增加10 μg/m3,与COVID-19风险比(滞后1至3天)升高有关[lag1: RR = 1.004;95% CI:(1.003-1.005), lag2: RR = 1.006;95% CI:(1.005-1.007), &滞后3:RR = 1.004;95% CI:(1.003-1.005)],随后病例减少。同样,最大风速上升4.47 m/s与滞后第4天病例的RR升高相关[lag4: RR = 1.009;95% CI:(1.003-1.014)],之后数字开始下降。最后,最低日能见度减少4.83 km与滞后第1和第2天病例的RR增加相关[lag1: RR = 1.031;95% CI: (1.023-1.039), lag2: RR = 1.018;95% CI:(1.011-1.024)],滞后3、4、5 d下降,滞后6、7 d回升[lag6: RR = 1.028;95% CI: (1.021-1.036), & lag7: RR = 1.046;95% ci:(1.038-1.055)]。影响埃尔帕索COVID-19病例的PM2.5、风速和能见度凸显了采取循证干预措施的必要性,包括信息、教育和沟通方案、预警系统、跨境空气质量管理、实时监测和更严格的排放控制。
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