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Is preschool child health surveillance an effective means of detecting key physical abnormalities? 学龄前儿童健康监测是发现关键身体异常的有效手段吗?
Pub Date : 2009-08-06 DOI: 10.1046/j.1467-0658.2000.0062e.x
Dr Cliona Ni Bhrolchain

Method This was a prospective study of a 1-year cohort of children born to mothers registered with 25% of general practices in Nottingham. A cohort of 2308 babies was followed up for 15–18 months. All referrals for five tracer physical conditions (undescended testes, congenital heart disease, squints, developmental dysplasia of the hip and congenital hearing loss) were followed up through hospital record systems and copies of child health surveillance reviews from the personal child health records.

Results One thousand, nine hundred and seventy-two (85%) of the initial cohort were followed up. Four hundred and thirteen (21%) children had been referred for one of the tracer conditions and 91% had been referred directly from child health surveillance reviews. Only 49 (12%) children needed treatment or follow-up after assessment. The sensitivity of screening was high, ranging from 72% for congenital heart disease to 100% for developmental dysplasia of the hip and hearing loss. However, false positive rates were also very high, ranging from 60% for undescended testes to 97% for developmental dysplasia of the hip and hearing loss. Thus the positive predictive value of referral for dysplasia of the hip or hearing loss was only 5%, with a negative predictive value of 100%. In contrast, the positive predictive value for undescended testes was 67%, with a false negative rate of 14%. Eighty-four per cent of those who needed treatment or follow-up after assessment had been referred from the child health surveillance programme. The largest proportion of abnormalities was identified from the 6-week review, but most referrals came from the neonatal review and the health visitor distraction test.

Conclusion The majority of children with the five tracer conditions used in this study were identified during child health surveillance examinations.

方法:本研究是一项前瞻性研究,对诺丁汉25%的全科医生注册的母亲所生的1年队列儿童进行研究。对2308名婴儿进行了15-18个月的随访。通过医院记录系统和儿童个人健康记录的儿童健康监测审查副本,对所有因五种示踪性身体状况(睾丸隐睾、先天性心脏病、斜视、髋关节发育不良和先天性听力损失)转诊的患者进行随访。结果随访1272例(85%)。413名(21%)儿童因其中一种示踪条件而转诊,91%的儿童直接从儿童健康监测审查中转诊。只有49名(12%)儿童在评估后需要治疗或随访。筛查的灵敏度很高,从先天性心脏病的72%到髋关节发育不良和听力损失的100%。然而,假阳性率也很高,从睾丸隐睾的60%到髋关节发育不良和听力损失的97%不等。因此,髋部发育不良或听力损失转诊的阳性预测值仅为5%,阴性预测值为100%。相比之下,隐睾阳性预测值为67%,假阴性率为14%。在评估后需要治疗或随访的儿童中,有84%是从儿童健康监测方案转介过来的。在6周的复查中发现了最大比例的异常,但大多数转诊来自新生儿复查和健康访问者分心测试。结论本研究中使用的五种示踪条件的大多数儿童是在儿童健康监测检查中发现的。
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引用次数: 0
Addressing barriers to change: an RCT of practice-based education to improve the management of hypertension in the elderly. 解决改变的障碍:一项基于实践的教育改善老年人高血压管理的随机对照试验。
Pub Date : 2009-08-06 DOI: 10.1046/j.1467-0658.2000.0062d.x
Cliona Ni Bhrolchain Dr

Method A randomised, single-blind, controlled trial of incorporating an exploration of barriers to changing practice into an educational strategy for GPs was conducted in 18 practices. Both groups of practices received visits during which they received the results of a previous audit on the management of hypertension in the elderly. The nine intervention practices were encouraged to explore barriers that would prevent them from implementing the pertinent research findings, in addition to an exploration of the issues and creation of a practice action plan. Control groups received the education without the element of exploring barriers to change. The outcome measures were changes in response to a questionnaire before and after the educational intervention.

Results There were statistically significant differences between the two groups after the educational visit. Those practices who were encouraged to explore barriers to change were more likely to show change in behaviour compared to the control group. All the intervention practices produced an action plan for improving the performance, whereas none of the controls did so. The intervention practices also showed more concordance in management protocols after the intervention.

Conclusion Addressing the barriers preventing practitioners from implementing research findings is effective in implementing change.

方法采用随机、单盲、对照试验的方法,对18个全科医生的培训策略中改变实践的障碍进行探讨。两组医生都接受了访问,在此期间,他们收到了先前对老年人高血压管理的审计结果。除了探索问题和制定实践行动计划外,还鼓励九种干预做法探索阻碍其实施相关研究结果的障碍。对照组接受的教育不包含探索改变障碍的内容。结果测量是在教育干预前后对问卷的反应变化。结果教育访视后两组患者的治疗效果差异有统计学意义。与对照组相比,那些被鼓励探索改变障碍的人更有可能表现出行为上的变化。所有的干预实践都产生了一个改善绩效的行动计划,而没有一个对照组这样做。干预后各干预实践在管理协议上也表现出更强的一致性。解决阻碍从业者实施研究成果的障碍是实施变革的有效途径。
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引用次数: 0
Addressing barriers to change: an RCT of practice-based education to improve the management of hypertension in the elderly. 解决改变的障碍:一项基于实践的教育改善老年人高血压管理的随机对照试验。
Pub Date : 2009-08-06 DOI: 10.1046/j.1467-0658.2000.0062c.x
Cliona Ni Bhrolchain Dr

Method A randomised, single-blind, controlled trial of incorporating an exploration of barriers to changing practice into an educational strategy for GPs was conducted in 18 practices. Both groups of practices received visits during which they received the results of a previous audit on the management of hypertension in the elderly. The nine intervention practices were encouraged to explore barriers that would prevent them from implementing the pertinent research findings, in addition to an exploration of the issues and creation of a practice action plan. Control groups received the education without the element of exploring barriers to change. The outcome measures were changes in response to a questionnaire before and after the educational intervention.

Results There were statistically significant differences between the two groups after the educational visit. Those practices who were encouraged to explore barriers to change were more likely to show change in behaviour compared to the control group. All the intervention practices produced an action plan for improving the performance, whereas none of the controls did so. The intervention practices also showed more concordance in management protocols after the intervention.

Conclusion Addressing the barriers preventing practitioners from implementing research findings is effective in implementing change.

方法采用随机、单盲、对照试验的方法,对18个全科医生的培训策略中改变实践的障碍进行探讨。两组医生都接受了访问,在此期间,他们收到了先前对老年人高血压管理的审计结果。除了探索问题和制定实践行动计划外,还鼓励九种干预做法探索阻碍其实施相关研究结果的障碍。对照组接受的教育不包含探索改变障碍的内容。结果测量是在教育干预前后对问卷的反应变化。结果教育访视后两组患者的治疗效果差异有统计学意义。与对照组相比,那些被鼓励探索改变障碍的人更有可能表现出行为上的变化。所有的干预实践都产生了一个改善绩效的行动计划,而没有一个对照组这样做。干预后各干预实践在管理协议上也表现出更强的一致性。解决阻碍从业者实施研究成果的障碍是实施变革的有效途径。
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引用次数: 2
Recurrent periorbital zosteriform herpes simplex virus infection in childhood 儿童复发性眶周带状疱疹病毒感染
Pub Date : 2009-08-06 DOI: 10.1046/j.1467-0658.2000.00056.x
Tibisay Villalobos, Megan C McMahon, Mobeen H Rathore

Introduction Zosteriform herpes simplex virus (HSV) infection is an uncommon presentation of HSV recurrent cutaneous infection and it is usually misdiagnosed as zoster.

Methods We report a series of consecutive cases of zosteriform HSV that we recently managed.

Results Four cases of recurrent zosteriform HSV infection in the second division of the trigeminal nerve were seen. Immunologic evaluation determined that the patients were immunocompetent. Culture and/or direct fluorescent stain diagnosed HSV. No ocular involvement was present, and all patients responded to oral acyclovir.

Recommendations Clinicians should suspect HSV infection in patients with recurrent vesicular lesions with zosteriform appearance. Immunologic evaluation is not necessary; however, ophthalmologic examination to exclude ocular involvement is required. Oral acyclovir is useful for treatment.

摘要带状疱疹病毒(HSV)感染是一种罕见的复发性皮肤感染,常被误诊为带状疱疹。方法我们报告了我们最近处理的一系列连续的带状疱疹病例。结果在三叉神经二段出现4例复发性带状疱疹感染。免疫评价表明患者具有免疫能力。培养和/或直接荧光染色诊断HSV。没有眼部受累,所有患者对口服阿昔洛韦有反应。临床医生应怀疑反复出现带状疱疹样水疱性病变的患者感染HSV。免疫评价是不必要的;然而,眼科检查排除眼部受累是必要的。口服阿昔洛韦对治疗是有用的。
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引用次数: 2
Population screening for anaemia in the inner city 在市中心进行人口贫血筛查
Pub Date : 2009-08-06 DOI: 10.1046/j.1467-0658.2000.00057.x
Robert Moy, Anne Aukett

Objective An evaluation of the effectiveness and acceptability of a screening programme for anaemia linked to routine child health surveillance.

Design A community-based study of the screening process with re-evaluation after treatment and again 9 months later, supported by a questionnaire study of the opinions of GPs, health visitors and parents.

Setting Child Health clinics and GP surgeries in an area of Birmingham with high levels of deprivation and ethnic minority groups.

Subjects All 625 children turning 21 months of age during a 2-month period who were resident in the study area.

Main outcome measures Attendance for screening, haemoglobin result, compliance with medication, and post-treatment haemoglobin.

Results Sixty-three per cent of the target population attended for blood screening. 46% of 365 children tested were anaemic (Hb < 110 g/L). The thumb-prick blood test was acceptable to children, parents and health visitors. Two months of iron therapy was effective in raising haemoglobin by a mean of 15.5 g/l, but one-third of cases were noncompliant with oral iron. At 30 months of age, haemoglobin tended to fall in those previously not anaemic at 21 months from a mean of 122.2 to 115.5 g/l, and 33% who had been successfully treated later relapsed.

Conclusions The effectiveness of the programme from the public health perspective was reduced by nonattendance. Nevertheless, it could identify and treat anaemic children successfully. Despite shortcomings, we feel that screening is a useful adjunct to ongoing primary prevention of anaemia.

目的评价与儿童常规健康监测相关的贫血筛查方案的有效性和可接受性。设计一项以社区为基础的筛查过程研究,在治疗后和9个月后再次进行评估,并对全科医生、卫生访视员和家长的意见进行问卷调查。在伯明翰贫困程度高和少数民族群体的地区设立儿童保健诊所和全科医生手术。研究对象:625名在2个月内居住在研究区域的21个月大的儿童。主要观察指标:参加筛查、血红蛋白结果、药物依从性和治疗后血红蛋白。结果63%的目标人群参加了血液筛查。在365名接受检测的儿童中,46%患有贫血(Hb <110 g / L)。儿童、家长和健康巡视员都能接受拇指刺血测试。两个月的铁治疗可使血红蛋白平均提高15.5 g/l,但三分之一的病例不符合口服铁治疗。在30个月大时,以前没有贫血的患者血红蛋白在21个月时从平均122.2 g/l下降到115.5 g/l,并且33%成功治疗的患者后来复发。结论从公共卫生角度来看,该计划的有效性因缺勤而降低。然而,它可以成功地识别和治疗贫血儿童。尽管有缺点,但我们认为筛查是对正在进行的贫血初级预防的有用辅助。
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引用次数: 6
Biosketches 简历
Pub Date : 2009-08-06 DOI: 10.1046/j.1467-0658.2000.0059a.x
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引用次数: 0
Biosketches 简历
Pub Date : 2009-08-06 DOI: 10.1046/j.1467-0658.2000.0054a.x
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引用次数: 0
Psychopharmacotherapy in children and adults with intellectual disability. 智力残疾儿童和成人的精神药物治疗。
Pub Date : 2009-08-06 DOI: 10.1046/j.1467-0658.2000.0062m.x
Richard Reading

The prevalence of psychiatric disorders is increased in children and adults with intellectual disability. Brain damage or dysfunction interact with social and family factors to increase susceptibility to mental illness. Psychiatric disorders in the context of genetic syndromes are commonly overlooked, and there is substantial underdiagnosis of mental disorders because of the atypical and non-specific clinical presentations, and the frequent assumption that psychiatric symptoms are an inherent part of the underlying intellectual disability. There is a strong need for evidence-based practice in the use of drugs in this population, especially since many are unlicensed for use in children. There is an urgent need to understand and establish the pharmacokinetics, pharmacodynamics, and side-effect profiles of psychotropic medication in this population. Positive trends in pharmacotherapy include the use of atypical antipsychotics instead of the classic antipsychotics, serotonin-specific reuptake inhibitors (SSRIs) rather than tricyclic antidepressants and newer antiepileptic drugs. Another welcome trend is the use of SSRIs instead of antipsychotics in the long-term management of challenging behaviour in this population.

在智力残疾的儿童和成人中,精神疾病的患病率有所增加。脑损伤或功能障碍与社会和家庭因素相互作用,增加对精神疾病的易感性。在遗传综合征的背景下,精神障碍通常被忽视,由于非典型和非特异性的临床表现,以及经常假设精神症状是潜在智力残疾的固有部分,因此对精神障碍的诊断严重不足。在这一人群中使用药物时,迫切需要以证据为基础的实践,特别是因为许多药物未经许可用于儿童。迫切需要了解和建立精神药物在这一人群中的药代动力学、药效学和副作用概况。药物治疗的积极趋势包括使用非典型抗精神病药物而不是经典抗精神病药物,使用血清素特异性再摄取抑制剂(SSRIs)而不是三环抗抑郁药和新型抗癫痫药物。另一个受欢迎的趋势是在这一人群中使用ssri类药物代替抗精神病药物长期管理具有挑战性的行为。
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引用次数: 12
A randomised trial of three marketing strategies to disseminate a screening and brief alcohol intervention programme to general practitioners. 三种营销策略的随机试验,向全科医生传播筛查和简短的酒精干预方案。
Pub Date : 2009-08-06 DOI: 10.1046/j.1467-0658.2000.0062a.x
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引用次数: 0
Commentary 评论
Pub Date : 2009-08-06 DOI: 10.1046/j.1467-0658.2000.0057b.x
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引用次数: 0
期刊
Ambulatory Child Health
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