Pub Date : 2020-01-28DOI: 10.3760/CMA.J.ISSN.1007-8118.2020.01.013
Jian-hua Li, Ling Han
Objective To investigate the effect of microRNA-128 (miR-128) on the proliferation, apoptosis on the hepatoma cells. Methods The target genes of miR-128 were analyzed by using bioinformatics and dual luciferase reporter assay system. We overexpressed miR-128 in the MHCC97H cells and also infected the GP73 gene with virus in the cell. Cell proliferation was detected by cell counting kit and apoptosis was detected by TUNEL and apoptosis index was calculated. Thirty 6-8 weeks Balb/c nude mice were randomly divided into miR-128 overexpression group (n=15) and control group (n=15). Results The results of bioinformatics and dual luciferase reporter assay showed that GP73 was the target gene of miR-128. Compared with the negative control group, cell proliferation in miR-128 overexpression group was decreased significantly; compared with miR-128+ empty plasmid group, cell in miR-128+ GP73 group was significantly increased (P<0.05). Compared with the negative control group, the apoptosis index in miR-128 overexpression group was significantly increased (P<0.05). Compared with miR-128 + empty plasmid group, the apoptosis index of miR-128 + GP73 group was significantly increased (P<0.05). Tumor volume of the overexpression group was higher than that of the control group. 5 weeks later, tumor volume of the miR-128 overexpression group (1 209±108)mm3 was significantly higher than that of the control group (1 985±298)mm3, the difference was statistically significant (P<0.05). Conclusion miR-128 can promote the proliferation and inhibit the apoptosis of hepatoma cells by regulating GP73, which provide a reference for the prognosis evaluation of hepatoma. Key words: Liver neoplasms; MicroRNA-128; Golgi protein-73; Cell proliferation; Apoptosis
{"title":"Effect and mechanism of microRNA-128 on proliferation and apoptosis of hepatocelluar carcinoma cells","authors":"Jian-hua Li, Ling Han","doi":"10.3760/CMA.J.ISSN.1007-8118.2020.01.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-8118.2020.01.013","url":null,"abstract":"Objective \u0000To investigate the effect of microRNA-128 (miR-128) on the proliferation, apoptosis on the hepatoma cells. \u0000 \u0000 \u0000Methods \u0000The target genes of miR-128 were analyzed by using bioinformatics and dual luciferase reporter assay system. We overexpressed miR-128 in the MHCC97H cells and also infected the GP73 gene with virus in the cell. Cell proliferation was detected by cell counting kit and apoptosis was detected by TUNEL and apoptosis index was calculated. Thirty 6-8 weeks Balb/c nude mice were randomly divided into miR-128 overexpression group (n=15) and control group (n=15). \u0000 \u0000 \u0000Results \u0000The results of bioinformatics and dual luciferase reporter assay showed that GP73 was the target gene of miR-128. Compared with the negative control group, cell proliferation in miR-128 overexpression group was decreased significantly; compared with miR-128+ empty plasmid group, cell in miR-128+ GP73 group was significantly increased (P<0.05). Compared with the negative control group, the apoptosis index in miR-128 overexpression group was significantly increased (P<0.05). Compared with miR-128 + empty plasmid group, the apoptosis index of miR-128 + GP73 group was significantly increased (P<0.05). Tumor volume of the overexpression group was higher than that of the control group. 5 weeks later, tumor volume of the miR-128 overexpression group (1 209±108)mm3 was significantly higher than that of the control group (1 985±298)mm3, the difference was statistically significant (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000miR-128 can promote the proliferation and inhibit the apoptosis of hepatoma cells by regulating GP73, which provide a reference for the prognosis evaluation of hepatoma. \u0000 \u0000 \u0000Key words: \u0000Liver neoplasms; MicroRNA-128; Golgi protein-73; Cell proliferation; Apoptosis","PeriodicalId":10021,"journal":{"name":"Chinese Journal of Hepatobiliary Surgery","volume":"26 1","pages":"57-60"},"PeriodicalIF":0.0,"publicationDate":"2020-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48839607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-28DOI: 10.3760/CMA.J.ISSN.1007-8118.2020.01.018
Jie Lin, Z. Zeng
Hepatic ischemia-reperfusion injury is often occurred during the hepatobiliary surgery, and is closely correlated with postoperative of liver function recovery and prognosis. Although the mechanisms of hepatic ischemia-reperfusion injury are complex, mitochondrial structural dysfunction is an important event for hepatic ischemia-reperfusion injury. This review summarized the current mechanism of hepatic ischemia-reperfusion injury, and with a focus on mitigating its damage through the mitochondrial autophagy and apoptosis pathway. Key words: Reperfusion injury; Liver; Mitochondria
{"title":"Effect of mitochondrial pathway on hepatic ischemia-reperfusion injury","authors":"Jie Lin, Z. Zeng","doi":"10.3760/CMA.J.ISSN.1007-8118.2020.01.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-8118.2020.01.018","url":null,"abstract":"Hepatic ischemia-reperfusion injury is often occurred during the hepatobiliary surgery, and is closely correlated with postoperative of liver function recovery and prognosis. Although the mechanisms of hepatic ischemia-reperfusion injury are complex, mitochondrial structural dysfunction is an important event for hepatic ischemia-reperfusion injury. This review summarized the current mechanism of hepatic ischemia-reperfusion injury, and with a focus on mitigating its damage through the mitochondrial autophagy and apoptosis pathway. \u0000 \u0000Key words: \u0000Reperfusion injury; Liver; Mitochondria","PeriodicalId":10021,"journal":{"name":"Chinese Journal of Hepatobiliary Surgery","volume":"26 1","pages":"69-72"},"PeriodicalIF":0.0,"publicationDate":"2020-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43693695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-28DOI: 10.3760/CMA.J.ISSN.1007-8118.2020.01.003
Jianliang Xu, Yi Lu, Baoding Zhuang, Yi Zhang, Yanjie Li, Mingxing Xu, M. Deng
Objective To study the clinical use of microwave scalpel in hepatectomy for hepatocellular carcinoma without hepatic vascular inflow occlusion. Methods A retrospective study was conducted on the clinical data of 126 consecutive patients with hepatocellular carcinoma who were treated at the Department of Hepatobiliary Surgery of the Third Affiliated Hospital of Sun Yat-sen University from December 2015 to August 2018. The patients included 111 males and 15 females, with ages which ranged from 25 to 75 years. These patients were divided into two groups by the different surgical resection methods: the microwave scalpel hepatectomy (MSH) group which employed microwave scalpels to perform hepatectomy (n=42), and the ultrasound scalpel hepatectomy (USH) group which employed ultrasound scalpels (n=84). The perioperative conditions which included baseline data, amount of intraoperative bleeding, liver function after operation, and morbidity of postoperative complications were compared. Results There were no significant differences in the preoperative indexes which included tumor diameter, number of tumors, levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) between the 2 groups (all P>0.05). In the MSH group, the amount of intraoperative bleeding was 100.0 (100.0, 200.0) ml, which was significantly lower than the 300.0 (100.0, 400.0) ml in the USH group (P<0.05). Compared with the USH group, the levels of AST and ALT on postoperative day 1, 3, 7 after operation in the MSH group were significantly lower (all P<0.05), and the corresponding albumin levels were significantly higher than the USH group (P<0.05). The incidence of complications was 4.8%(2/42) in the MSH group which was significantly lower than that of 20.2%(17/84) in the USH group (P<0.05). Conclusion Microwave scalpel significantly reduced intraoperative bleeding and postoperative complications, and led to less liver functional injury. Key words: Carcinoma, hepatocellular; Hepatectomy; Microwave scalpel; Ultrasound scalpel; Intraoperative bleeding; Liver function
{"title":"Use of microwave scalpel in hepatectomy for hepatocellular carcinoma","authors":"Jianliang Xu, Yi Lu, Baoding Zhuang, Yi Zhang, Yanjie Li, Mingxing Xu, M. Deng","doi":"10.3760/CMA.J.ISSN.1007-8118.2020.01.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-8118.2020.01.003","url":null,"abstract":"Objective \u0000To study the clinical use of microwave scalpel in hepatectomy for hepatocellular carcinoma without hepatic vascular inflow occlusion. \u0000 \u0000 \u0000Methods \u0000A retrospective study was conducted on the clinical data of 126 consecutive patients with hepatocellular carcinoma who were treated at the Department of Hepatobiliary Surgery of the Third Affiliated Hospital of Sun Yat-sen University from December 2015 to August 2018. The patients included 111 males and 15 females, with ages which ranged from 25 to 75 years. These patients were divided into two groups by the different surgical resection methods: the microwave scalpel hepatectomy (MSH) group which employed microwave scalpels to perform hepatectomy (n=42), and the ultrasound scalpel hepatectomy (USH) group which employed ultrasound scalpels (n=84). The perioperative conditions which included baseline data, amount of intraoperative bleeding, liver function after operation, and morbidity of postoperative complications were compared. \u0000 \u0000 \u0000Results \u0000There were no significant differences in the preoperative indexes which included tumor diameter, number of tumors, levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) between the 2 groups (all P>0.05). In the MSH group, the amount of intraoperative bleeding was 100.0 (100.0, 200.0) ml, which was significantly lower than the 300.0 (100.0, 400.0) ml in the USH group (P<0.05). Compared with the USH group, the levels of AST and ALT on postoperative day 1, 3, 7 after operation in the MSH group were significantly lower (all P<0.05), and the corresponding albumin levels were significantly higher than the USH group (P<0.05). The incidence of complications was 4.8%(2/42) in the MSH group which was significantly lower than that of 20.2%(17/84) in the USH group (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Microwave scalpel significantly reduced intraoperative bleeding and postoperative complications, and led to less liver functional injury. \u0000 \u0000 \u0000Key words: \u0000Carcinoma, hepatocellular; Hepatectomy; Microwave scalpel; Ultrasound scalpel; Intraoperative bleeding; Liver function","PeriodicalId":10021,"journal":{"name":"Chinese Journal of Hepatobiliary Surgery","volume":"26 1","pages":"10-14"},"PeriodicalIF":0.0,"publicationDate":"2020-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47189817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-28DOI: 10.3760/CMA.J.ISSN.1007-8118.2020.01.004
Min Wu, Dingwei Xu, Min Sun, Jie Huang
Objective To study the clinical value of three-dimensional CT reconstruction model of portal venous system combined with finite element analysis to measure portal venous pressure in patients with portal hypertension. Methods A retrospective study was conducted on 27 patients who were diagnosed to have portal hypertension at the Second Affiliated Hospital of Kunming Medical University from May 2016 to May 2018. There were 17 males and 10 females, with ages ranging from 34 to 77 years (mean 56 years). All these patients underwent transjugular intrahepatic portal venous shunt (TIPS) during which the portal venous pressure was measured. The imaging data was imported into the three-dimensional software of medical imaging to reconstruct the three dimensional model of portal vein, and the finite element analysis software of ANSYS was used to calculate the portal venous pressure by calculation with given boundary conditions. Pearson correlation was used to analyze the correlation between the actual measurement of portal venous pressure and the predicted value. Results The actual measured value of portal vein pressure before TIPS in 27 patients with portal hypertension was (3 783±930) Pa, and the predicted value was (4 238±1 218) Pa. There was no significant difference (P>0.05). The predicted value of portal venous pressure was positively correlated with the actual measured value (r=0.402, 95%CI: 0.026-0.678, P<0.05). Conclusion Non-invasive measurement of portal venous pressure based on three-dimensional portal venous reconstruction combined with finite element analysis correlated with actual portal venous pressure in patients with portal hypertension. Key words: Hypertension, portal; Imaging, three-dimensional; Multislice spiral computerized tomography; Correlation
{"title":"Clinical value of portal venous pressure based on three dimensional reconstruction model of portal vein combined with finite element analysis in patients with portal hypertension","authors":"Min Wu, Dingwei Xu, Min Sun, Jie Huang","doi":"10.3760/CMA.J.ISSN.1007-8118.2020.01.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-8118.2020.01.004","url":null,"abstract":"Objective \u0000To study the clinical value of three-dimensional CT reconstruction model of portal venous system combined with finite element analysis to measure portal venous pressure in patients with portal hypertension. \u0000 \u0000 \u0000Methods \u0000A retrospective study was conducted on 27 patients who were diagnosed to have portal hypertension at the Second Affiliated Hospital of Kunming Medical University from May 2016 to May 2018. There were 17 males and 10 females, with ages ranging from 34 to 77 years (mean 56 years). All these patients underwent transjugular intrahepatic portal venous shunt (TIPS) during which the portal venous pressure was measured. The imaging data was imported into the three-dimensional software of medical imaging to reconstruct the three dimensional model of portal vein, and the finite element analysis software of ANSYS was used to calculate the portal venous pressure by calculation with given boundary conditions. Pearson correlation was used to analyze the correlation between the actual measurement of portal venous pressure and the predicted value. \u0000 \u0000 \u0000Results \u0000The actual measured value of portal vein pressure before TIPS in 27 patients with portal hypertension was (3 783±930) Pa, and the predicted value was (4 238±1 218) Pa. There was no significant difference (P>0.05). The predicted value of portal venous pressure was positively correlated with the actual measured value (r=0.402, 95%CI: 0.026-0.678, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Non-invasive measurement of portal venous pressure based on three-dimensional portal venous reconstruction combined with finite element analysis correlated with actual portal venous pressure in patients with portal hypertension. \u0000 \u0000 \u0000Key words: \u0000Hypertension, portal; Imaging, three-dimensional; Multislice spiral computerized tomography; Correlation","PeriodicalId":10021,"journal":{"name":"Chinese Journal of Hepatobiliary Surgery","volume":"1 1","pages":"15-18"},"PeriodicalIF":0.0,"publicationDate":"2020-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69884382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-28DOI: 10.3760/CMA.J.ISSN.1007-8118.2020.01.020
Cheng Huang, Xiao-dong Zhu, Yinghao Shen, Hui-Chuan Sun
The disease burden of hepatocellular carcinoma (HCC) remains large both in China and globally. In particular, advanced HCC lacks of effective systemic therapeutic drugs. Recently immune checkpoint inhibitors such as nivolumab and pembrolizumab have been approved for second-line treatment in patients with advanced HCC by the U. S. Food and Drug Administration (FDA). Compare with traditional chemotherapy or targeted therapy, these novel pharmacological approaches have unique therapeutic features, such as durable response, delayed response and manageable safety profile with specific immune-related adverse events that require monitoring. We aim to summarize the characteristics of immuno-oncology therapies on aspects of long-term outcome, response mechanisms and assessment, safety, and special populations, based on clinical trials and real-world data on patients with HCC. Key words: Carcinoma, hepatocellular; Immunotherapy; Immune checkpoint inhibitors
{"title":"Features of immune checkpoint inhibitor therapies in patients with hepatocellular carcinoma","authors":"Cheng Huang, Xiao-dong Zhu, Yinghao Shen, Hui-Chuan Sun","doi":"10.3760/CMA.J.ISSN.1007-8118.2020.01.020","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-8118.2020.01.020","url":null,"abstract":"The disease burden of hepatocellular carcinoma (HCC) remains large both in China and globally. In particular, advanced HCC lacks of effective systemic therapeutic drugs. Recently immune checkpoint inhibitors such as nivolumab and pembrolizumab have been approved for second-line treatment in patients with advanced HCC by the U. S. Food and Drug Administration (FDA). Compare with traditional chemotherapy or targeted therapy, these novel pharmacological approaches have unique therapeutic features, such as durable response, delayed response and manageable safety profile with specific immune-related adverse events that require monitoring. We aim to summarize the characteristics of immuno-oncology therapies on aspects of long-term outcome, response mechanisms and assessment, safety, and special populations, based on clinical trials and real-world data on patients with HCC. \u0000 \u0000Key words: \u0000Carcinoma, hepatocellular; Immunotherapy; Immune checkpoint inhibitors","PeriodicalId":10021,"journal":{"name":"Chinese Journal of Hepatobiliary Surgery","volume":"26 1","pages":"75-80"},"PeriodicalIF":0.0,"publicationDate":"2020-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44493053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To analyze the clinical characteristics, diagnosis, treatment and prognostic factors of primary hepatic neuroendocrine tumor (PHNET). Methods To analyze the clinical data of 21 patients with PHNET who were admitted to the First Affiliated Hospital of Zhengzhou University from January 2012 to January 2019. There were 11 males and 10 females, with ages which ranged from 36 to 75 years. Log-rank test was used for single-factor analysis of the relationship between clinical and pathological indicators and prognosis. Cox proportional risk model was used for multi-factor analysis. Results Among the 21 PHNET patients, 10 presented with central and upper abdominal pain, 3 abdominal pain accompanied by nausea and vomiting, 5 abdominal distension, and 3 were asymptomatic. Carbohydrate antigen (CA) 19-9 was elevated in 6 patients and CA125 in 7 patients. Abdominal enhanced CT showed solid liver space occupying lesions. Four patients had solitary and 17 had multiple lesions. The mean diameter was 58 mm. Fourteen patients had lymph node metastasis. Five patients underwent radical hepatectomy, 2 transcatheter hepatic arterial chemoembolization + chemotherapy, 12 chemotherapy, and 2 supportive treatment. Factors which were associated with prognosis of PHNET patients were surgery, tumor grading, cytokeratin positivity and lymph node metastasis. Multivariate Cox regression analysis showed that inoperability (HR=8.99, 95%CI: 1.13-71.80) was an independent risk factor of prognosis of PHNET patients. The prognosis in patients who underwent surgical resection was better. Conclusion Patients with PHNET had no specific clinical manifestations. Surgical resection gave the best results in treatment. As surgical resection affected prognosis, it should be carried out if technically feasible. Key words: Diagnosis; Primary liver neuroendocrine tumor; Clinical characteristics; Influencing factor
{"title":"Clinical characteristics and prognostic factors of primary hepatic neuroendocrine tumor: a study of 21 patients","authors":"Wei Feng, Menghao Zhou, Tan Zhang, Zu-jiang Yu, Zhuyin Li, Longshuan Zhao","doi":"10.3760/CMA.J.ISSN.1007-8118.2020.01.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-8118.2020.01.005","url":null,"abstract":"Objective \u0000To analyze the clinical characteristics, diagnosis, treatment and prognostic factors of primary hepatic neuroendocrine tumor (PHNET). \u0000 \u0000 \u0000Methods \u0000To analyze the clinical data of 21 patients with PHNET who were admitted to the First Affiliated Hospital of Zhengzhou University from January 2012 to January 2019. There were 11 males and 10 females, with ages which ranged from 36 to 75 years. Log-rank test was used for single-factor analysis of the relationship between clinical and pathological indicators and prognosis. Cox proportional risk model was used for multi-factor analysis. \u0000 \u0000 \u0000Results \u0000Among the 21 PHNET patients, 10 presented with central and upper abdominal pain, 3 abdominal pain accompanied by nausea and vomiting, 5 abdominal distension, and 3 were asymptomatic. Carbohydrate antigen (CA) 19-9 was elevated in 6 patients and CA125 in 7 patients. Abdominal enhanced CT showed solid liver space occupying lesions. Four patients had solitary and 17 had multiple lesions. The mean diameter was 58 mm. Fourteen patients had lymph node metastasis. Five patients underwent radical hepatectomy, 2 transcatheter hepatic arterial chemoembolization + chemotherapy, 12 chemotherapy, and 2 supportive treatment. Factors which were associated with prognosis of PHNET patients were surgery, tumor grading, cytokeratin positivity and lymph node metastasis. Multivariate Cox regression analysis showed that inoperability (HR=8.99, 95%CI: 1.13-71.80) was an independent risk factor of prognosis of PHNET patients. The prognosis in patients who underwent surgical resection was better. \u0000 \u0000 \u0000Conclusion \u0000Patients with PHNET had no specific clinical manifestations. Surgical resection gave the best results in treatment. As surgical resection affected prognosis, it should be carried out if technically feasible. \u0000 \u0000 \u0000Key words: \u0000Diagnosis; Primary liver neuroendocrine tumor; Clinical characteristics; Influencing factor","PeriodicalId":10021,"journal":{"name":"Chinese Journal of Hepatobiliary Surgery","volume":"26 1","pages":"19-21"},"PeriodicalIF":0.0,"publicationDate":"2020-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41421296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Analyze the incidence of colorectal diseases after liver transplantation. From March 2004 to February 2018, 32 recipients of hepatitis B liver transplantation in the Affiliated Hospital of Qingdao University were enrolled in the liver transplantation group, including 27 males and 5 females, aged (57.2 ± 9.8) years. 96 patients with chronic hepatitis B who underwent electronic colonoscopy in the Affiliated Hospital of Qingdao University from January 2016 to May 2018 were selected to be included in the hepatitis B group, including 80 men and 16 women, aged (56.8 ± 9.9) years; 96 cases with normal physical examination were included in the control group, including 78 males and 18 females, aged (56.4 ± 7.7) years old. In the liver transplantation group, there were 20 cases of colorectal polyps (62.5%, 20/32), 53 cases of colorectal polyps (55.2%, 53/96) in the hepatitis B group, and 46 cases of colorectal polyps (47.9%, 46/96) in the control group. There was no statistically significant difference in the incidence of colorectal polyps among the three groups (P>0.05). The incidence of colorectal polyps after liver transplantation is relatively high, and clinical doctors in liver transplantation should pay attention to routine electronic colonoscopy examination of liver transplant recipients after surgery.
{"title":"Colonoscopy screening results analysis of 32 cases with liver transplantation for HBV related liver diseases","authors":"Dongyue Liu, M. Xie, Ying-jun Jiang, Yonghong Xu, W. Rao, Yunjin Zang, Xinjuan Kong","doi":"10.3760/CMA.J.ISSN.1007-8118.2020.01.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-8118.2020.01.014","url":null,"abstract":"分析肝移植术后结直肠疾病发病情况。选择2004年3月至2018年2月青岛大学附属医院乙肝肝移植受者32例纳入肝移植组，其中男性27例，女性5例，年龄(57.2±9.8)岁。选择2016年1月至2018年5月青岛大学附属医院行电子结肠镜检查的慢性乙肝患者96例纳入乙肝组，其中男性80例，女性16例，年龄(56.8±9.9)岁；体检正常者96例纳入对照组，其中男性78例，女性18例，年龄(56.4±7.7)岁。肝移植组中结直肠息肉20例(62.5%，20/32)，乙肝组结直肠息肉53例(55.2%，53/96)，对照组结直肠息肉46例(47.9%，46/96)。三组结直肠息肉发生率比较差异无统计学意义(P>0.05)。肝移植术后结直肠息肉发生率偏高，肝移植临床医生应重视肝移植受者术后的常规电子结肠镜检查。","PeriodicalId":10021,"journal":{"name":"Chinese Journal of Hepatobiliary Surgery","volume":"26 1","pages":"61-62"},"PeriodicalIF":0.0,"publicationDate":"2020-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43502960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hepatic ischemia-reperfusion injury (HIRI) is the main cause of liver damage and even multiple organ failure after complex liver surgery. When liver ischemia reperfusion occurs, the non-coding RNAs in the liver tissue is dysregulated and part of the non-coding RNAs with abnormal expression is involved in HIRI regulation. Non-coding RNAs to may be the intervention target for reducing HIRI. This article summarized the types and related functions of non-coding RNAs, the role of different non-coding RNAs in HIRI, and the interconnections between various non-coding RNAs in HIRI. Key words: Reperfusion injury; Liver; Non-coding RNA; MicroRNA; Small interfering RNA
{"title":"Research progress of non-coding RNA in hepatic ischemia-reperfusion injury","authors":"Shilong Zhang, Zanjie Feng, Cijun Peng, Weidong Gao, Yuling Duan, Guoxin Fan","doi":"10.3760/CMA.J.ISSN.1007-8118.2020.01.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-8118.2020.01.019","url":null,"abstract":"Hepatic ischemia-reperfusion injury (HIRI) is the main cause of liver damage and even multiple organ failure after complex liver surgery. When liver ischemia reperfusion occurs, the non-coding RNAs in the liver tissue is dysregulated and part of the non-coding RNAs with abnormal expression is involved in HIRI regulation. Non-coding RNAs to may be the intervention target for reducing HIRI. This article summarized the types and related functions of non-coding RNAs, the role of different non-coding RNAs in HIRI, and the interconnections between various non-coding RNAs in HIRI. \u0000 \u0000Key words: \u0000Reperfusion injury; Liver; Non-coding RNA; MicroRNA; Small interfering RNA","PeriodicalId":10021,"journal":{"name":"Chinese Journal of Hepatobiliary Surgery","volume":"26 1","pages":"72-75"},"PeriodicalIF":0.0,"publicationDate":"2020-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42546245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-28DOI: 10.3760/CMA.J.ISSN.1007-8118.2020.01.002
Lei Liu, R. Liao, Xufu Wei, Chengyou Du
Objective To study the association between ratio of peritumoral hepatic stellate cells to γδ T cells ratio (SGR) and prognosis of patients with hepatocellular carcinoma (HCC) after curative resection. Methods From January 2011 to December 2013, the clinical data of 320 patients with HCC who underwent curative resection at the Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University were collected and analyzed retrospectively. Immunohistochemistry was used to calculate the SGR in adjacent cancer tissues. Survival was estimated by Kaplan-Meier method. Prognosis of HCC patients was analyzed by univariate and multivariate analyses. Results Multivariate analysis revealed multiple tumors (HR=1.895, 95%CI: 1.155-3.108), microvascular invasion (HR=1.665, 95%CI: 1.104-2.512), tumor size >5 cm (HR=2.400, 95%CI: 1.603-3.594) and peritumoral SGR>18 (HR=1.880, 95%CI: 1.257-2.810) were independent risk factors of the overall survival rate in HCC patients. Preoperative AFP>20 μg/L (HR=1.631, 95%CI: 1.151-2.311), microvascular invasion (HR=2.145, 95%CI: 1.536-2.994), tumor size >5 cm (HR=1.866, 95%CI: 1.342-2.592) and peritumoral SGR>18 (HR=1.517, 95%CI: 1.084-2.122) were independent risk factors of the tumor-free survival rate in HCC patients. Patients were then divided into the low SGR (ratio≤18, n=222) and high SGR groups (ratio>18, n=98) using SGR in adjacent cancer tissues. The overall survival and tumor-free survival rates of the low SGR group were significantly better than the high SGR group (P<0.05). Conclusion Peritumoral SGR was an independent prognostic factor of patients with HCC following radical resection. The prognosis of patients with low SGR was better. Key words: Carcinoma, hepatocellular; Hepatic stellate cells; γδT lymphocytes; Tumor microenvironment; Prognosis
{"title":"Prognostic relationship between ratio of peritumoral hepatic stellate cells to γδ T cells and prognosis of patients with hepatocellular carcinoma after curative resection","authors":"Lei Liu, R. Liao, Xufu Wei, Chengyou Du","doi":"10.3760/CMA.J.ISSN.1007-8118.2020.01.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-8118.2020.01.002","url":null,"abstract":"Objective \u0000To study the association between ratio of peritumoral hepatic stellate cells to γδ T cells ratio (SGR) and prognosis of patients with hepatocellular carcinoma (HCC) after curative resection. \u0000 \u0000 \u0000Methods \u0000From January 2011 to December 2013, the clinical data of 320 patients with HCC who underwent curative resection at the Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University were collected and analyzed retrospectively. Immunohistochemistry was used to calculate the SGR in adjacent cancer tissues. Survival was estimated by Kaplan-Meier method. Prognosis of HCC patients was analyzed by univariate and multivariate analyses. \u0000 \u0000 \u0000Results \u0000Multivariate analysis revealed multiple tumors (HR=1.895, 95%CI: 1.155-3.108), microvascular invasion (HR=1.665, 95%CI: 1.104-2.512), tumor size >5 cm (HR=2.400, 95%CI: 1.603-3.594) and peritumoral SGR>18 (HR=1.880, 95%CI: 1.257-2.810) were independent risk factors of the overall survival rate in HCC patients. Preoperative AFP>20 μg/L (HR=1.631, 95%CI: 1.151-2.311), microvascular invasion (HR=2.145, 95%CI: 1.536-2.994), tumor size >5 cm (HR=1.866, 95%CI: 1.342-2.592) and peritumoral SGR>18 (HR=1.517, 95%CI: 1.084-2.122) were independent risk factors of the tumor-free survival rate in HCC patients. Patients were then divided into the low SGR (ratio≤18, n=222) and high SGR groups (ratio>18, n=98) using SGR in adjacent cancer tissues. The overall survival and tumor-free survival rates of the low SGR group were significantly better than the high SGR group (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Peritumoral SGR was an independent prognostic factor of patients with HCC following radical resection. The prognosis of patients with low SGR was better. \u0000 \u0000 \u0000Key words: \u0000Carcinoma, hepatocellular; Hepatic stellate cells; γδT lymphocytes; Tumor microenvironment; Prognosis","PeriodicalId":10021,"journal":{"name":"Chinese Journal of Hepatobiliary Surgery","volume":"26 1","pages":"6-9"},"PeriodicalIF":0.0,"publicationDate":"2020-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45020546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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