Yuzhu Li, Shixuan Yang, Cheng Qu, Zhongxiang Ding, Honglin Liu
Toward the challenge on reliable determination of food contaminants to ensure food safety and security, surface-enhanced Raman spectroscopy (SERS) technology with single-molecule sensitivity through their “fingerprint” Raman signal has been developed into a fundamental and important molecular toolkit for food industry. Currently, hydrogel is attracting great interests in SERS sensing as a functional and flexible material. In this perspective, we first introduce the classification of common hydrogel and strategies for the synthesis of SERS substrates. Next, we highlight the response characteristics of hydrogel, including temperature response and pH response. Finally, we summarize the applications of hydrogel-based substrates for food contaminant detection and discuss its developing trends and challenges. Compared to traditional solid SERS substrates, hydrogel-based substrates have encouraging characteristics, such as unique flexibility to adhere to food surfaces for direct target molecule collection, and the stable three-dimensional network scaffold that prevents the aggregation of SERS hot spots, etc. These advantages suggest that hydrogel-based substrates have great potential for food safety analysis and monitoring.
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Edible oils rich in unsaturated fatty acids are essential components of a healthy diet. However, food safety problems existing in these seemingly healthy oils can be overlooked. Recently, a new study by Prof. Gertrud Morlock, Chair of Food Sciences at Justus Liebig University Giessen and her Ph.D. student, Daniel Meyer, found that healthy oils recommended for daily consumption may contain a considerable amount of genotoxic compounds hazardous to human health. The study, published in the journal Food Chemistry, also demonstrates the application of newly developed non-target planar genotoxicity profiling method for detecting genotoxic compounds in edible oils.
Genotoxic compounds are substances that can induce DNA damage and are potential carcinogens. They are widely present in a variety of sources, including food, air, and water. While some well-known genotoxic compounds are easily detected and regulated, others may be overlooked due to the selective nature or lack of sensitivity of current analytical techniques. The researchers hypothesized that some less studied genotoxic compounds are present in healthy food materials that escape detection and exist as a source of hazards in the household products. Thus, the development of a more sensitive and untargeted bio-analytical method is much needed. To this end, they sampled 33 oil samples including 31 healthy oils from local households and studied them under different household storage conditions. Analysis using a planar genotoxicity bioassay that combines separation with effect detection on the same surface allows sensitive detection of genotoxins in the oils. This bioassay employs high-performance thin-layer chromatography coupled with a genetically modified Salmonella typhimurium strain equipped with the SOS-Umu-C repair mechanism. The genotoxic compound zones were then characterized by high-resolution mass spectrometry.
The study revealed that genotoxic substances, such as epoxides and hydroperoxides produced due to the oxidation of unsaturated fatty acids, were detected in multiple oil samples. Moreover, the amount of genotoxic compounds in the oils increased with prolonged storage and air exposure. This is the first method capable of detecting genotoxic compounds in edible oils, in a generic and sensitive manner.
Overall, the study has important implications for public health and food safety. It provides a potential solution to the problem of detecting a spectrum of genotoxic compounds in foods and other sources. It also highlights the need for more sensitive and accurate analytical techniques that can cover a wide range of toxic compounds in food analysis. On top of this, the study underscores the importance of continued research into the sources of genotoxicity in food, feed, dietary supplements, and cosmetics.
In the future, more studies are needed to redefine good manufacturing practices, safe product formulations, and proper storage conditions to ensure the
{"title":"Novel analytical method detects genotoxic compounds in edible oils","authors":"Danyue Zhao","doi":"10.1002/fsh3.12016","DOIUrl":"https://doi.org/10.1002/fsh3.12016","url":null,"abstract":"<p>Edible oils rich in unsaturated fatty acids are essential components of a healthy diet. However, food safety problems existing in these seemingly healthy oils can be overlooked. Recently, a new study by Prof. Gertrud Morlock, Chair of Food Sciences at Justus Liebig University Giessen and her Ph.D. student, Daniel Meyer, found that healthy oils recommended for daily consumption may contain a considerable amount of genotoxic compounds hazardous to human health. The study, published in the journal Food Chemistry, also demonstrates the application of newly developed non-target planar genotoxicity profiling method for detecting genotoxic compounds in edible oils.</p><p>Genotoxic compounds are substances that can induce DNA damage and are potential carcinogens. They are widely present in a variety of sources, including food, air, and water. While some well-known genotoxic compounds are easily detected and regulated, others may be overlooked due to the selective nature or lack of sensitivity of current analytical techniques. The researchers hypothesized that some less studied genotoxic compounds are present in healthy food materials that escape detection and exist as a source of hazards in the household products. Thus, the development of a more sensitive and untargeted bio-analytical method is much needed. To this end, they sampled 33 oil samples including 31 healthy oils from local households and studied them under different household storage conditions. Analysis using a planar genotoxicity bioassay that combines separation with effect detection on the same surface allows sensitive detection of genotoxins in the oils. This bioassay employs high-performance thin-layer chromatography coupled with a genetically modified <i>Salmonella typhimurium</i> strain equipped with the SOS-Umu-C repair mechanism. The genotoxic compound zones were then characterized by high-resolution mass spectrometry.</p><p>The study revealed that genotoxic substances, such as epoxides and hydroperoxides produced due to the oxidation of unsaturated fatty acids, were detected in multiple oil samples. Moreover, the amount of genotoxic compounds in the oils increased with prolonged storage and air exposure. This is the first method capable of detecting genotoxic compounds in edible oils, in a generic and sensitive manner.</p><p>Overall, the study has important implications for public health and food safety. It provides a potential solution to the problem of detecting a spectrum of genotoxic compounds in foods and other sources. It also highlights the need for more sensitive and accurate analytical techniques that can cover a wide range of toxic compounds in food analysis. On top of this, the study underscores the importance of continued research into the sources of genotoxicity in food, feed, dietary supplements, and cosmetics.</p><p>In the future, more studies are needed to redefine good manufacturing practices, safe product formulations, and proper storage conditions to ensure the","PeriodicalId":100546,"journal":{"name":"Food Safety and Health","volume":"1 2","pages":"106"},"PeriodicalIF":0.0,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/fsh3.12016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68180475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}