首页 > 最新文献

Infectious Medicine最新文献

英文 中文
Mycobacterium tuberculosis joint infections: A case series 结核分枝杆菌关节感染:病例系列
Pub Date : 2024-06-01 DOI: 10.1016/j.imj.2024.100107
Gui Luo, Jinshui Yang, Qianqian Zhao, Jian Zhu, Jianglin Zhang, Zheng Zhao

Tuberculosis is a chronic infectious disease, caused by Mycobacterium tuberculosis, that seriously endangers human health. Skeletal tuberculosis is the most common type of extrapulmonary tuberculosis and tuberculous arthritis is the second most common type of skeletal tuberculosis. We report a case series of patients with tuberculous arthritis, two of whom had no joint disease in the past and presented as monoarthritis. The final patient had a history of rheumatoid arthritis, with polyarthritis that was aggravated during treatment with glucocorticoids and immunosuppressive drugs. This series of cases can contribute to early diagnosis and treatment with appropriate infection control measures.

结核病是由结核分枝杆菌引起的一种严重危害人类健康的慢性传染病。骨骼结核是肺外结核中最常见的类型,而结核性关节炎则是骨骼结核中第二常见的类型。我们报告了一组结核性关节炎患者的病例,其中两名患者过去没有关节疾病,表现为单发性关节炎。最后一名患者有类风湿性关节炎病史,并伴有多关节炎,在使用糖皮质激素和免疫抑制剂治疗期间病情加重。这一系列病例有助于采取适当的感染控制措施进行早期诊断和治疗。
{"title":"Mycobacterium tuberculosis joint infections: A case series","authors":"Gui Luo,&nbsp;Jinshui Yang,&nbsp;Qianqian Zhao,&nbsp;Jian Zhu,&nbsp;Jianglin Zhang,&nbsp;Zheng Zhao","doi":"10.1016/j.imj.2024.100107","DOIUrl":"10.1016/j.imj.2024.100107","url":null,"abstract":"<div><p>Tuberculosis is a chronic infectious disease, caused by <em>Mycobacterium tuberculosis</em>, that seriously endangers human health. Skeletal tuberculosis is the most common type of extrapulmonary tuberculosis and tuberculous arthritis is the second most common type of skeletal tuberculosis. We report a case series of patients with tuberculous arthritis, two of whom had no joint disease in the past and presented as monoarthritis. The final patient had a history of rheumatoid arthritis, with polyarthritis that was aggravated during treatment with glucocorticoids and immunosuppressive drugs. This series of cases can contribute to early diagnosis and treatment with appropriate infection control measures.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000212/pdfft?md5=eb90e1029a7c070059c6186679c72eb3&pid=1-s2.0-S2772431X24000212-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140794552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review of the recombination events, mechanisms and consequences of Coxsackievirus A6 柯萨奇病毒 A6 重组事件、机制和后果综述
Pub Date : 2024-06-01 DOI: 10.1016/j.imj.2024.100115
Zequn Wang , Hongling Wen

Hand, foot, and mouth disease (HFMD) is one of the most common class C infectious diseases, posing a serious threat to public health worldwide. Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) have been regarded as the major pathogenic agents of HFMD; however, since an outbreak caused by coxsackievirus A6 (CV-A6) in France in 2008, CV-A6 has gradually become the predominant pathogen in many regions. CV-A6 infects not only children but also adults, and causes atypical clinical symptoms such as a more generalized rash, eczema herpeticum, high fever, and onychomadesis, which are different from the symptoms associated with EV-A71 and CV-A16. Importantly, the rate of genetic recombination of CV-A6 is high, which can lead to changes in virulence and the rapid evolution of other characteristics, thus posing a serious threat to public health. To date, no specific vaccines or therapeutics have been approved for CV-A6 prevention or treatment, hence it is essential to fully understand the relationship between recombination and evolution of this virus. Here, we systematically review the genetic recombination events of CV-A6 that have occurred worldwide and explore how these events have promoted virus evolution, thus providing important information regarding future HFMD surveillance and prevention.

手足口病(HFMD)是最常见的丙类传染病之一,对全球公共卫生构成严重威胁。肠道病毒 A71(EV-A71)和柯萨奇病毒 A16(CV-A16)一直被视为手足口病的主要病原体,但自 2008 年柯萨奇病毒 A6(CV-A6)在法国爆发以来,CV-A6 已逐渐成为许多地区的主要病原体。CV-A6 不仅感染儿童,也感染成人,并引起非典型临床症状,如全身皮疹、疱疹性湿疹、高烧和寰疱症,这些症状与 EV-A71 和 CV-A16 的相关症状不同。重要的是,CV-A6 的基因重组率很高,可导致毒力变化和其他特征的快速进化,从而对公共卫生构成严重威胁。迄今为止,尚未批准用于 CV-A6 预防或治疗的特定疫苗或疗法,因此,充分了解该病毒的基因重组与进化之间的关系至关重要。在此,我们系统回顾了全球范围内发生的 CV-A6 基因重组事件,并探讨了这些事件是如何促进病毒进化的,从而为未来手足口病的监测和预防提供重要信息。
{"title":"A review of the recombination events, mechanisms and consequences of Coxsackievirus A6","authors":"Zequn Wang ,&nbsp;Hongling Wen","doi":"10.1016/j.imj.2024.100115","DOIUrl":"10.1016/j.imj.2024.100115","url":null,"abstract":"<div><p>Hand, foot, and mouth disease (HFMD) is one of the most common class C infectious diseases, posing a serious threat to public health worldwide. Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) have been regarded as the major pathogenic agents of HFMD; however, since an outbreak caused by coxsackievirus A6 (CV-A6) in France in 2008, CV-A6 has gradually become the predominant pathogen in many regions. CV-A6 infects not only children but also adults, and causes atypical clinical symptoms such as a more generalized rash, eczema herpeticum, high fever, and onychomadesis, which are different from the symptoms associated with EV-A71 and CV-A16. Importantly, the rate of genetic recombination of CV-A6 is high, which can lead to changes in virulence and the rapid evolution of other characteristics, thus posing a serious threat to public health. To date, no specific vaccines or therapeutics have been approved for CV-A6 prevention or treatment, hence it is essential to fully understand the relationship between recombination and evolution of this virus. Here, we systematically review the genetic recombination events of CV-A6 that have occurred worldwide and explore how these events have promoted virus evolution, thus providing important information regarding future HFMD surveillance and prevention.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100115"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000297/pdfft?md5=c55b20e7169853252373ef4b99b3d656&pid=1-s2.0-S2772431X24000297-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology and etiology of hand, foot, and mouth disease in Zhengzhou, China, from 2009 to 2021 2009 年至 2021 年中国郑州手足口病的流行病学和病因学情况
Pub Date : 2024-06-01 DOI: 10.1016/j.imj.2024.100114
Bowen Dai , Yu Chen , Shujie Han , Shouhang Chen , Fang Wang , Huifen Feng , Xiaolong Zhang , Wenlong Li , Shuaiyin Chen , Haiyan Yang , Guangcai Duan , Guowei Li , Yuefei Jin

Background

Hand, foot, and mouth disease (HFMD) is a common childhood infectious disease caused by a variety of enteroviruses (EVs). To explore the epidemiological characteristics and etiology of HFMD in Zhengzhou, China, we conducted a systematic analysis of HFMD surveillance data from Zhengzhou Center for Disease Control and Prevention from January 2009 to December 2021 (https://wjw.zhengzhou.gov.cn/).

Methods

Surveillance data were collected from Zhengzhou Center for Disease Control and Prevention from January 2009 to December 2021 (https://wjw.zhengzhou.gov.cn/). Cases were analyzed according to the time of onset, type of diagnosis, characteristics, viral serotype, and epidemiological trends.

Results

We found that the primary causative agent responsible for the HFMD outbreaks in Zhengzhou was Enterovirus A71 (EVA-71) (48.56%) before 2014. After 2015, other EVs gradually became the dominant strains (57.68%). The data revealed that the HFMD epidemics in Zhengzhou displayed marked seasonality, with major peaks occurring from April to June, followed by secondary peaks from October to November, except in 2020. Both the severity and case-fatality ratio of HFMD decreased following the COVID-19 pandemic (severity ‰: 13.46 vs. 0.17; case-fatality ‰: 0.21 vs. 0, respectively). Most severe cases were observed in patients aged 1 year and below, accounting for 45.81%.

Conclusions

Overall, the incidence rate of HFMD decreased in Zhengzhou following the introduction of the EVA-71 vaccine in 2016. However, it is crucial to acknowledge that HFMD prevalence continues to exhibit a distinct seasonal pattern and periodicity, and the occurrence of other EV infections poses a new challenge for children's health.

背景手足口病(HFMD)是由多种肠道病毒(EV)引起的儿童常见传染病。为了探讨手足口病在中国郑州的流行病学特征和病因,我们对郑州市疾病预防控制中心2009年1月至2021年12月(https://wjw.zhengzhou.gov.cn/)的手足口病监测数据进行了系统分析。方法从郑州市疾病预防控制中心收集了2009年1月至2021年12月(https://wjw.zhengzhou.gov.cn/)的监测数据。结果我们发现,2014 年以前,郑州市手足口病暴发的主要病原体是肠道病毒 A71(EVA-71)(占 48.56%)。2015 年后,其他肠道病毒逐渐成为优势毒株(57.68%)。数据显示,郑州手足口病流行具有明显的季节性,除2020年外,主要高峰出现在4月至6月,10月至11月为次高峰。COVID-19 流行后,手足口病的严重程度和病死率均有所下降(严重程度‰:13.46 vs. 0.17;病死率‰:0.21 vs. 0)。结论总体而言,在2016年引入EVA-71疫苗后,郑州的手足口病发病率有所下降。然而,手足口病的流行仍然具有明显的季节性和周期性,其他病毒感染的发生也给儿童健康带来了新的挑战,这一点至关重要。
{"title":"Epidemiology and etiology of hand, foot, and mouth disease in Zhengzhou, China, from 2009 to 2021","authors":"Bowen Dai ,&nbsp;Yu Chen ,&nbsp;Shujie Han ,&nbsp;Shouhang Chen ,&nbsp;Fang Wang ,&nbsp;Huifen Feng ,&nbsp;Xiaolong Zhang ,&nbsp;Wenlong Li ,&nbsp;Shuaiyin Chen ,&nbsp;Haiyan Yang ,&nbsp;Guangcai Duan ,&nbsp;Guowei Li ,&nbsp;Yuefei Jin","doi":"10.1016/j.imj.2024.100114","DOIUrl":"10.1016/j.imj.2024.100114","url":null,"abstract":"<div><h3>Background</h3><p>Hand, foot, and mouth disease (HFMD) is a common childhood infectious disease caused by a variety of enteroviruses (EVs). To explore the epidemiological characteristics and etiology of HFMD in Zhengzhou, China, we conducted a systematic analysis of HFMD surveillance data from Zhengzhou Center for Disease Control and Prevention from January 2009 to December 2021 (<span>https://wjw.zhengzhou.gov.cn/</span><svg><path></path></svg>).</p></div><div><h3>Methods</h3><p>Surveillance data were collected from Zhengzhou Center for Disease Control and Prevention from January 2009 to December 2021 (<span>https://wjw.zhengzhou.gov.cn/</span><svg><path></path></svg>). Cases were analyzed according to the time of onset, type of diagnosis, characteristics, viral serotype, and epidemiological trends.</p></div><div><h3>Results</h3><p>We found that the primary causative agent responsible for the HFMD outbreaks in Zhengzhou was Enterovirus A71 (EVA-71) (48.56%) before 2014. After 2015, other EVs gradually became the dominant strains (57.68%). The data revealed that the HFMD epidemics in Zhengzhou displayed marked seasonality, with major peaks occurring from April to June, followed by secondary peaks from October to November, except in 2020. Both the severity and case-fatality ratio of HFMD decreased following the COVID-19 pandemic (severity ‰: 13.46 vs. 0.17; case-fatality ‰: 0.21 vs. 0, respectively). Most severe cases were observed in patients aged 1 year and below, accounting for 45.81%.</p></div><div><h3>Conclusions</h3><p>Overall, the incidence rate of HFMD decreased in Zhengzhou following the introduction of the EVA-71 vaccine in 2016. However, it is crucial to acknowledge that HFMD prevalence continues to exhibit a distinct seasonal pattern and periodicity, and the occurrence of other EV infections poses a new challenge for children's health.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100114"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000285/pdfft?md5=6d7a9212964c42f8995b1c28c7bdfc6a&pid=1-s2.0-S2772431X24000285-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140759717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metagenomic next-generation sequencing identified a brain abscess caused by mixed oral anaerobe infection: A case report 元基因组下一代测序确定了口腔厌氧菌混合感染引起的脑脓肿:病例报告
Pub Date : 2024-06-01 DOI: 10.1016/j.imj.2024.100109
Zepeng Ma , Hui Liu , Ming Liu , Yuhao Wang , Chao Li , Yifei Xu

Fusobacterium vincentii brain abscesses are relatively rare. Here, we report our treatment of an anaerobic brain abscess caused by a mixed infection of Parvimonas micra, Streptococcus constellatus, Fusobacterium vincentii, and Bacteroides heparinolyticus diagnosed by metagenomic next-generation sequencing (mNGS). This is the first reported case of Fusobacterium vincentii in a brain abscess. This case highlights the possibility that oral anaerobic microbes can cause a brain abscess and demonstrates that mNGS has the potential to be deployed to provide rapid infection diagnosis and rationalize antimicrobial therapy for brain abscesses.

长春分枝杆菌脑脓肿相对罕见。在此,我们报告了通过元基因组下一代测序(mNGS)诊断出的由微小副葡萄球菌、 constellatus 链球菌、长春分枝杆菌和肝溶解杆菌混合感染引起的厌氧性脑脓肿的治疗情况。这是首例在脑脓肿中发现文森特镰刀菌的病例。该病例强调了口腔厌氧微生物导致脑脓肿的可能性,并证明 mNGS 有潜力用于提供快速感染诊断和合理的脑脓肿抗菌治疗。
{"title":"Metagenomic next-generation sequencing identified a brain abscess caused by mixed oral anaerobe infection: A case report","authors":"Zepeng Ma ,&nbsp;Hui Liu ,&nbsp;Ming Liu ,&nbsp;Yuhao Wang ,&nbsp;Chao Li ,&nbsp;Yifei Xu","doi":"10.1016/j.imj.2024.100109","DOIUrl":"10.1016/j.imj.2024.100109","url":null,"abstract":"<div><p><em>Fusobacterium vincentii</em> brain abscesses are relatively rare. Here, we report our treatment of an anaerobic brain abscess caused by a mixed infection of <em>Parvimonas micra, Streptococcus constellatus, Fusobacterium vincentii</em>, and <em>Bacteroides heparinolyticus</em> diagnosed by metagenomic next-generation sequencing (mNGS). This is the first reported case of <em>Fusobacterium vincentii</em> in a brain abscess. This case highlights the possibility that oral anaerobic microbes can cause a brain abscess and demonstrates that mNGS has the potential to be deployed to provide rapid infection diagnosis and rationalize antimicrobial therapy for brain abscesses.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100109"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000236/pdfft?md5=253f37c9df90ed0530a320cc94a698f6&pid=1-s2.0-S2772431X24000236-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140759643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highly pathogenic avian influenza A (H5N1) virus outbreak in Peru in 2022–2023 2022-2023 年秘鲁爆发高致病性甲型禽流感(H5N1)病毒疫情
Pub Date : 2024-06-01 DOI: 10.1016/j.imj.2024.100108
Nieves Sevilla , Wendy Lizarraga , Victor Jimenez-Vasquez , Veronica Hurtado , Iris S. Molina , Lilian Huarca , Priscila Lope-Pari , Ivan Vargas , Gloria Arotinco , Carlos Padilla-Rojas

Background

An epizootic of highly pathogenic avian influenza A (H5N1) has spread worldwide since 2022. Even though this virus has been extensively studied for many decades, little is known about its evolution in South America.

Methods

Here, we describe the sequencing and characterization of 13 H5N1 genomes collected from wild birds, poultry, and wild mammals in Peru during the genomic surveillance of this outbreak.

Results

The samples belonged to the highly pathogenic avian influenza (H5N1) 2.3.4.4b clade. Chilean and Peruvian samples clustered in the same group and therefore share a common ancestor. An analysis of the hemagglutinin and neuraminidase genes detected new mutations, some dependent upon the host type.

Conclusions

The genomic surveillance of highly pathogenic avian influenza is necessary to promote the One Health policy and to overcome the new problems entailed by climate change, which may alter the habitats of resident and migratory birds.

背景自 2022 年以来,高致病性甲型禽流感(H5N1)在全球范围内蔓延。方法在此,我们描述了在此次疫情的基因组监测期间从秘鲁的野鸟、家禽和野生哺乳动物中收集的 13 个 H5N1 基因组的测序和特征描述。智利和秘鲁的样本聚集在同一组,因此具有共同的祖先。对血凝素和神经氨酸酶基因的分析发现了新的变异,其中一些变异取决于宿主类型。结论 对高致病性禽流感进行基因组监测对于促进 "统一健康政策 "和克服气候变化带来的新问题是必要的,气候变化可能会改变留鸟和候鸟的栖息地。
{"title":"Highly pathogenic avian influenza A (H5N1) virus outbreak in Peru in 2022–2023","authors":"Nieves Sevilla ,&nbsp;Wendy Lizarraga ,&nbsp;Victor Jimenez-Vasquez ,&nbsp;Veronica Hurtado ,&nbsp;Iris S. Molina ,&nbsp;Lilian Huarca ,&nbsp;Priscila Lope-Pari ,&nbsp;Ivan Vargas ,&nbsp;Gloria Arotinco ,&nbsp;Carlos Padilla-Rojas","doi":"10.1016/j.imj.2024.100108","DOIUrl":"10.1016/j.imj.2024.100108","url":null,"abstract":"<div><h3>Background</h3><p>An epizootic of highly pathogenic avian influenza A (H5N1) has spread worldwide since 2022. Even though this virus has been extensively studied for many decades, little is known about its evolution in South America.</p></div><div><h3>Methods</h3><p>Here, we describe the sequencing and characterization of 13 H5N1 genomes collected from wild birds, poultry, and wild mammals in Peru during the genomic surveillance of this outbreak.</p></div><div><h3>Results</h3><p>The samples belonged to the highly pathogenic avian influenza (H5N1) 2.3.4.4b clade. Chilean and Peruvian samples clustered in the same group and therefore share a common ancestor. An analysis of the hemagglutinin and neuraminidase genes detected new mutations, some dependent upon the host type.</p></div><div><h3>Conclusions</h3><p>The genomic surveillance of highly pathogenic avian influenza is necessary to promote the One Health policy and to overcome the new problems entailed by climate change, which may alter the habitats of resident and migratory birds.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000224/pdfft?md5=fa804259af594e61781a9193ac2b525d&pid=1-s2.0-S2772431X24000224-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140797128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expert consensus on One Health for establishing an enhanced and integrated surveillance system for key infectious diseases 关于 "一个健康 "的专家共识,以建立重点传染病强化综合监测系统
Pub Date : 2024-04-06 DOI: 10.1016/j.imj.2024.100106
Yanpeng Cheng , Zhen Zhang , Yuelong Shu , Lili Ren , Min Kang , Dongfeng Kong , Xiaolu Shi , Qiuying Lv , Zhigao Chen , Yinghui Li , Renli Zhang , Puxuan Lu , Yan Lu , Tingting Liu , Nixuan Chen , Huawei Xiong , Chen Du , Jun Yuan , Liang Wang , Rongqi Liu , Tiejian Feng

China has been continuously improving its monitoring methods and strategies to address key infectious diseases (KIDs). After the severe acute respiratory syndrome epidemic in 2003, China established a comprehensive reporting system for infectious diseases (IDs) and public health emergencies. The relatively lagging warning thresholds, limited warning information, and outdated warning technology are insufficient to meet the needs of comprehensive monitoring for modern KIDs. Strengthening early monitoring and warning capabilities to enhance the public health system has become a top priority, with increasing demand for early warning thresholds, information, and techniques, thanks to constant innovation and development in molecular biology, bioinformatics, artificial intelligence, and other identification and analysis technologies. A panel of 31 experts has recommended a fourth-generation comprehensive surveillance system targeting KIDs (41 notifiable diseases and emerging IDs). The aim of this surveillance system is to systematically monitor the epidemiology and causal pathogens of KIDs in hosts such as humans, animals, and vectors, along with associated environmental pathogens. By integrating factors influencing epidemic spread and risk assessment, the surveillance system can serve to detect, predict, and provide early warnings for the occurrence, development, variation, and spread of known or novel KIDs. Moreover, we recommend comprehensive ID monitoring based on the fourth-generation surveillance system, along with a data-integrated monitoring and early warning platform and a consortium pathogen detection technology system. This series of considerations is based on systematic and comprehensive monitoring across multiple sectors, dimensions, factors, and pathogens that is supported by data integration and connectivity. This expert consensus will provides an opportunity for collaboration in various fields and relies on interdisciplinary application to enhance comprehensive monitoring, prediction, and early warning capabilities for the next generation of ID surveillance. This expert consensus will serve as a reference for ID prevention and control as well as other related activities.

中国一直在不断改进重点传染病(KIDs)的监测方法和策略。2003 年严重急性呼吸系统综合征疫情发生后,中国建立了传染病(ID)和突发公共卫生事件综合报告制度。相对滞后的预警阈值、有限的预警信息、落后的预警技术,不足以满足现代 KID 全面监测的需要。随着分子生物学、生物信息学、人工智能等识别和分析技术的不断创新和发展,对预警阈值、预警信息和预警技术的要求也越来越高,加强早期监测和预警能力,提升公共卫生体系的水平已成为当务之急。一个由 31 位专家组成的小组建议针对 KID(41 种应呈报疾病和新出现的 ID)建立第四代综合监测系统。该监测系统旨在系统监测 KIDs 在人类、动物和病媒等宿主体内的流行病学和致病病原体,以及相关的环境病原体。通过整合影响流行病传播的因素和风险评估,该监测系统可用于检测、预测已知或新型 KID 的发生、发展、变异和传播,并提供预警。此外,我们还建议在第四代监测系统的基础上进行全面的 ID 监测,同时建立数据集成监测和预警平台以及病原体联合检测技术系统。这一系列考虑的基础是在数据集成和连接的支持下,对多个部门、多个维度、多个因素和病原体进行系统和全面的监测。本专家共识将为各领域的合作提供机会,并依靠跨学科应用来增强下一代 ID 监测的全面监测、预测和预警能力。本专家共识将为 ID 防控及其他相关活动提供参考。
{"title":"Expert consensus on One Health for establishing an enhanced and integrated surveillance system for key infectious diseases","authors":"Yanpeng Cheng ,&nbsp;Zhen Zhang ,&nbsp;Yuelong Shu ,&nbsp;Lili Ren ,&nbsp;Min Kang ,&nbsp;Dongfeng Kong ,&nbsp;Xiaolu Shi ,&nbsp;Qiuying Lv ,&nbsp;Zhigao Chen ,&nbsp;Yinghui Li ,&nbsp;Renli Zhang ,&nbsp;Puxuan Lu ,&nbsp;Yan Lu ,&nbsp;Tingting Liu ,&nbsp;Nixuan Chen ,&nbsp;Huawei Xiong ,&nbsp;Chen Du ,&nbsp;Jun Yuan ,&nbsp;Liang Wang ,&nbsp;Rongqi Liu ,&nbsp;Tiejian Feng","doi":"10.1016/j.imj.2024.100106","DOIUrl":"10.1016/j.imj.2024.100106","url":null,"abstract":"<div><p>China has been continuously improving its monitoring methods and strategies to address key infectious diseases (KIDs). After the severe acute respiratory syndrome epidemic in 2003, China established a comprehensive reporting system for infectious diseases (IDs) and public health emergencies. The relatively lagging warning thresholds, limited warning information, and outdated warning technology are insufficient to meet the needs of comprehensive monitoring for modern KIDs. Strengthening early monitoring and warning capabilities to enhance the public health system has become a top priority, with increasing demand for early warning thresholds, information, and techniques, thanks to constant innovation and development in molecular biology, bioinformatics, artificial intelligence, and other identification and analysis technologies. A panel of 31 experts has recommended a fourth-generation comprehensive surveillance system targeting KIDs (41 notifiable diseases and emerging IDs). The aim of this surveillance system is to systematically monitor the epidemiology and causal pathogens of KIDs in hosts such as humans, animals, and vectors, along with associated environmental pathogens. By integrating factors influencing epidemic spread and risk assessment, the surveillance system can serve to detect, predict, and provide early warnings for the occurrence, development, variation, and spread of known or novel KIDs. Moreover, we recommend comprehensive ID monitoring based on the fourth-generation surveillance system, along with a data-integrated monitoring and early warning platform and a consortium pathogen detection technology system. This series of considerations is based on systematic and comprehensive monitoring across multiple sectors, dimensions, factors, and pathogens that is supported by data integration and connectivity. This expert consensus will provides an opportunity for collaboration in various fields and relies on interdisciplinary application to enhance comprehensive monitoring, prediction, and early warning capabilities for the next generation of ID surveillance. This expert consensus will serve as a reference for ID prevention and control as well as other related activities.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000200/pdfft?md5=ca12c7ec5fb0dd197437dde782d43ce5&pid=1-s2.0-S2772431X24000200-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140782936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into the emergence and evolution of monkeypox virus: Historical perspectives, epidemiology, genetic diversity, transmission, and preventative measures 洞察猴痘病毒的出现和演变:历史视角、流行病学、遗传多样性、传播和预防措施
Pub Date : 2024-04-03 DOI: 10.1016/j.imj.2024.100105
Smriti Krishna , Chhaya Kurrey , Manisha Yadav , Shakuntala Mahilkar , Subash Chandra Sonkar , Naveen Kumar Vishvakarma , Anand Sonkar , Lal Chandra , Bidhan Chandra Koner

In 2022, just before the COVID-19 pandemic ended, many countries noticed a viral monkeypox outbreak. Monkeypox virus, a zoonotic pathogen, causes a febrile illness in humans and resembles smallpox. Prevention strategies encompass vaccination, strict infection control measures, and avoiding contact with infected persons. As monkeypox and related poxviruses continue to pose challenges, ongoing surveillance, early diagnosis, prompt isolation, and effective control measures are crucial for limiting transmission and mitigating the impact of outbreaks on public health. This review provides valuable insights into the evolution of the monkeypox virus and its various modes of transmission, including postmortem transmission, and offers an overall perspective on the guidelines issued by the Government of India to prevent and effectively control the spread of this disease.

2022 年,就在 COVID-19 大流行结束之前,许多国家发现爆发了猴痘病毒疫情。猴痘病毒是一种人畜共患的病原体,会导致人类发热,与天花相似。预防策略包括接种疫苗、采取严格的感染控制措施和避免与感染者接触。由于猴痘和相关痘病毒继续带来挑战,持续监测、早期诊断、及时隔离和有效的控制措施对于限制传播和减轻疫情爆发对公共卫生的影响至关重要。本综述对猴痘病毒的演变及其各种传播方式(包括死后传播)提供了有价值的见解,并对印度政府为预防和有效控制这种疾病的传播而发布的指导方针提供了一个整体视角。
{"title":"Insights into the emergence and evolution of monkeypox virus: Historical perspectives, epidemiology, genetic diversity, transmission, and preventative measures","authors":"Smriti Krishna ,&nbsp;Chhaya Kurrey ,&nbsp;Manisha Yadav ,&nbsp;Shakuntala Mahilkar ,&nbsp;Subash Chandra Sonkar ,&nbsp;Naveen Kumar Vishvakarma ,&nbsp;Anand Sonkar ,&nbsp;Lal Chandra ,&nbsp;Bidhan Chandra Koner","doi":"10.1016/j.imj.2024.100105","DOIUrl":"10.1016/j.imj.2024.100105","url":null,"abstract":"<div><p>In 2022, just before the COVID-19 pandemic ended, many countries noticed a viral monkeypox outbreak. Monkeypox virus, a zoonotic pathogen, causes a febrile illness in humans and resembles smallpox. Prevention strategies encompass vaccination, strict infection control measures, and avoiding contact with infected persons. As monkeypox and related poxviruses continue to pose challenges, ongoing surveillance, early diagnosis, prompt isolation, and effective control measures are crucial for limiting transmission and mitigating the impact of outbreaks on public health. This review provides valuable insights into the evolution of the monkeypox virus and its various modes of transmission, including postmortem transmission, and offers an overall perspective on the guidelines issued by the Government of India to prevent and effectively control the spread of this disease.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000194/pdfft?md5=5f6a35848bf4308c4aba538ba1c47380&pid=1-s2.0-S2772431X24000194-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporal patterns and clinical characteristics of healthcare-associated infections in surgery patients: A retrospective study in a major Chinese tertiary hospital 手术患者医源性感染的时间模式和临床特征:中国一家大型三级医院的回顾性研究
Pub Date : 2024-03-30 DOI: 10.1016/j.imj.2024.100103
Tianyi Zhang , Li Yan , Shan Wang , Ming Chen , Yunda Jiao , Zhuoqi Sheng , Jianchao Liu , Lihua Liu

Background

Given the preventable nature of most healthcare-associated infections (HAIs), it is crucial to understand their characteristics and temporal patterns to reduce their occurrence.

Methods

A retrospective analysis of medical record cover pages from a Chinese hospital information system was conducted for surgery inpatients from 2010 to 2019. Association rules mining (ARM) was employed to explore the association between disease, procedure, and HAIs. Joinpoint models were used to estimate the annual HAI trend. The time series of each type of HAI was decomposed to analyze the temporal patterns of HAIs.

Results

The study included data from 623,290 surgery inpatients over 10 years, and a significant decline in the HAI rate was observed. Compared with patients without HAIs, those with HAIs had a longer length of stay (29 days vs. 9 days), higher medical costs (96226.57 CNY vs. 22351.98 CNY), and an increased risk of death (6.42% vs. 0.18%). The most common diseases for each type of HAI differed, although bone marrow and spleen operations were the most frequent procedures for most HAI types. ARM detected that some uncommon diagnoses could strongly associate with HAIs. The time series pattern varied for each type of HAI, with the peak occurring in January for respiratory system infections, and in August and July for surgical site and bloodstream infections, respectively.

Conclusions

Our findings demonstrate that HAIs impose a significant burden on surgery patients. The differing time series patterns for each type of HAI highlight the importance of tailored surveillance strategies for specific types of HAI.

背景鉴于大多数医疗相关感染(HAIs)都是可以预防的,因此了解其特征和时间模式对减少其发生至关重要。方法对一家中国医院信息系统中2010年至2019年外科住院患者的病历封面进行了回顾性分析。采用关联规则挖掘(ARM)来探索疾病、手术和 HAIs 之间的关联。连接点模型用于估计每年的 HAI 趋势。研究纳入了10年间623,290名手术住院患者的数据,观察到HAI率显著下降。与未发生 HAI 的患者相比,发生 HAI 的患者住院时间更长(29 天对 9 天),医疗费用更高(96226.57 元对 22351.98 元),死亡风险更高(6.42% 对 0.18%)。虽然骨髓和脾脏手术是大多数 HAI 类型中最常见的手术,但每种 HAI 类型中最常见的疾病各不相同。ARM 发现,一些不常见的诊断可能与 HAI 密切相关。每种 HAI 的时间序列模式各不相同,呼吸系统感染的高峰期出现在 1 月份,手术部位感染和血流感染的高峰期分别出现在 8 月和 7 月。每种 HAI 的时间序列模式各不相同,这凸显了针对特定类型的 HAI 采取有针对性的监控策略的重要性。
{"title":"Temporal patterns and clinical characteristics of healthcare-associated infections in surgery patients: A retrospective study in a major Chinese tertiary hospital","authors":"Tianyi Zhang ,&nbsp;Li Yan ,&nbsp;Shan Wang ,&nbsp;Ming Chen ,&nbsp;Yunda Jiao ,&nbsp;Zhuoqi Sheng ,&nbsp;Jianchao Liu ,&nbsp;Lihua Liu","doi":"10.1016/j.imj.2024.100103","DOIUrl":"10.1016/j.imj.2024.100103","url":null,"abstract":"<div><h3>Background</h3><p>Given the preventable nature of most healthcare-associated infections (HAIs), it is crucial to understand their characteristics and temporal patterns to reduce their occurrence.</p></div><div><h3>Methods</h3><p>A retrospective analysis of medical record cover pages from a Chinese hospital information system was conducted for surgery inpatients from 2010 to 2019. Association rules mining (ARM) was employed to explore the association between disease, procedure, and HAIs. Joinpoint models were used to estimate the annual HAI trend. The time series of each type of HAI was decomposed to analyze the temporal patterns of HAIs.</p></div><div><h3>Results</h3><p>The study included data from 623,290 surgery inpatients over 10 years, and a significant decline in the HAI rate was observed. Compared with patients without HAIs, those with HAIs had a longer length of stay (29 days vs. 9 days), higher medical costs (96226.57 CNY vs. 22351.98 CNY), and an increased risk of death (6.42% vs. 0.18%). The most common diseases for each type of HAI differed, although bone marrow and spleen operations were the most frequent procedures for most HAI types. ARM detected that some uncommon diagnoses could strongly associate with HAIs. The time series pattern varied for each type of HAI, with the peak occurring in January for respiratory system infections, and in August and July for surgical site and bloodstream infections, respectively.</p></div><div><h3>Conclusions</h3><p>Our findings demonstrate that HAIs impose a significant burden on surgery patients. The differing time series patterns for each type of HAI highlight the importance of tailored surveillance strategies for specific types of HAI.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 2","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000170/pdfft?md5=0f63f57f8419c21f6bc25a081e9aee3e&pid=1-s2.0-S2772431X24000170-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection and genetic identification of Borrelia lusitaniae in questing Ixodes inopiatus tick from Tunisia 突尼斯蜱虫中卢西塔尼亚包柔氏菌的检测和基因鉴定
Pub Date : 2024-03-01 DOI: 10.1016/j.imj.2024.100093
Rachid Selmi , Khaoula Abdi , Hanène Belkahia , Meriem Ben Abdallah , Aymen Mamlouk , Myriam Kratou , Mourad Ben Said , Lilia Messadi

Background

Until now, there has been limited information on the prevalence and the phylogeny of Borrelia burgdorferi sensu lato in Ixodes ticks in Tunisia, particularly in Ixodes inopinatus.

Methods

The present study aimed to determine the prevalence and the phylogeny of B. burgdorferi s.l., in coexisted I. ricinus and I. inopinatus ticks collected from Northern Tunisia. One hundred questig ticks were collected during winter 2020 by tick-dragging method in Beja gouvernorate located in the north of Tunisia. Real-time PCR panel targeting B. burgdorferi s.l. 23S rRNA gene were performed. Positive DNA samples were subjected to conventional PCRs targeting 457 bp fragment of the Borrelia sp. flagellin (fla) gene using primers FlaF/FlaR. The identified Borrelia sp. isolate underwent partial sequence analysis to determine genospecies and evaluate their phylogenetic position.

Results

The study revealed a prevalence rate of 28% (28/100) for B. burgdorferi sensu lato in the Ixodes ticks. The prevalence rates across tick species and genders did not show significant variations (p > 0.05). Interestingly, the study underlines the coexistence of I. inopinatus and I. ricinus sharing the same geographic areas in Northern Tunisia. Furthermore, DNA of B. lusitaniae was detected in I. inopinatus ticks for the first time in Tunisia. Revealed B. lusitaniae bacterium is similar to previously identified strains in Mediterranean region, but distinct from those isolated exclusively from countries of Eastern and Central Europe, such as Serbia, Romania, and Poland. This study highlights the prevalence of B. burgdorferi s.l. in I. ricinus/I. inopinatus ticks, and reveals B. lusitaniae in I. inopinatus ticks for the first time in Tunisia.

Conclusion

These findings suggest the involvement of I. inopinatus as a potential vector of this pathogenic genospeciess in Tunisia. This may help understanding the ecology of Ixodes ticks, the natural infection and the transmission dynamics of Borrelia species in this country.

方法本研究旨在确定从突尼斯北部采集的共存蓖麻蜱和inopinatus蜱中的勃氏杆菌的流行率和系统发育。2020 年冬季,研究人员在突尼斯北部的贝哈省(Beja gouvernorate)采用拖蜱法收集了 100 只蜱虫。进行了针对 B. burgdorferi s.l. 23S rRNA 基因的实时 PCR 检测。使用引物 FlaF/FlaR 对阳性 DNA 样品进行传统 PCR 检测,检测波氏杆菌鞭毛蛋白(la)基因的 457 bp 片段。对鉴定出的包柔氏菌分离物进行了部分序列分析,以确定包柔氏菌的种属并评估其系统发育位置。不同种类和性别的蜱虫感染率差异不大(p > 0.05)。有趣的是,这项研究强调,在突尼斯北部,I. inopinatus 和 I. ricinus 在同一地理区域共存。此外,突尼斯首次在I. inopinatus蜱虫体内检测到了B.所发现的 B. lusitaniae 细菌与之前在地中海地区发现的菌株相似,但与只从塞尔维亚、罗马尼亚和波兰等东欧和中欧国家分离出来的菌株不同。本研究强调了 B. burgdorferi s.l. 在 I. ricinus/I. inopinatus 蜱虫中的流行情况,并首次在突尼斯 I. inopinatus 蜱虫中发现了 B. lusitaniae。这可能有助于了解 Ixodes ticks 的生态学、自然感染以及鲍瑞氏杆菌在该国的传播动态。
{"title":"Detection and genetic identification of Borrelia lusitaniae in questing Ixodes inopiatus tick from Tunisia","authors":"Rachid Selmi ,&nbsp;Khaoula Abdi ,&nbsp;Hanène Belkahia ,&nbsp;Meriem Ben Abdallah ,&nbsp;Aymen Mamlouk ,&nbsp;Myriam Kratou ,&nbsp;Mourad Ben Said ,&nbsp;Lilia Messadi","doi":"10.1016/j.imj.2024.100093","DOIUrl":"https://doi.org/10.1016/j.imj.2024.100093","url":null,"abstract":"<div><h3>Background</h3><p>Until now, there has been limited information on the prevalence and the phylogeny of <em>Borrelia burgdorferi</em> sensu lato in <em>Ixodes</em> ticks in Tunisia, particularly in <em>Ixodes inopinatus</em>.</p></div><div><h3>Methods</h3><p>The present study aimed to determine the prevalence and the phylogeny of <em>B. burgdorferi</em> s.l., in coexisted <em>I. ricinus</em> and <em>I. inopinatus</em> ticks collected from Northern Tunisia. One hundred questig ticks were collected during winter 2020 by tick-dragging method in Beja gouvernorate located in the north of Tunisia. Real-time PCR panel targeting <em>B. burgdorferi</em> s.l. 23S rRNA gene were performed. Positive DNA samples were subjected to conventional PCRs targeting 457 bp fragment of the <em>Borrelia</em> sp. flagellin (<em>fla</em>) gene using primers FlaF/FlaR. The identified <em>Borrelia</em> sp. isolate underwent partial sequence analysis to determine genospecies and evaluate their phylogenetic position.</p></div><div><h3>Results</h3><p>The study revealed a prevalence rate of 28% (28/100) for <em>B. burgdorferi</em> sensu lato in the <em>Ixodes</em> ticks. The prevalence rates across tick species and genders did not show significant variations (<em>p</em> &gt; 0.05). Interestingly, the study underlines the coexistence of <em>I. inopinatus</em> and <em>I. ricinus</em> sharing the same geographic areas in Northern Tunisia. Furthermore, DNA of <em>B. lusitaniae</em> was detected in <em>I. inopinatus</em> ticks for the first time in Tunisia. Revealed <em>B. lusitaniae</em> bacterium is similar to previously identified strains in Mediterranean region, but distinct from those isolated exclusively from countries of Eastern and Central Europe, such as Serbia, Romania, and Poland. This study highlights the prevalence of <em>B. burgdorferi</em> s.l. in <em>I. ricinus</em>/<em>I. inopinatus</em> ticks, and reveals <em>B. lusitaniae</em> in <em>I. inopinatus</em> ticks for the first time in Tunisia.</p></div><div><h3>Conclusion</h3><p>These findings suggest the involvement of <em>I. inopinatus</em> as a potential vector of this pathogenic genospeciess in Tunisia. This may help understanding the ecology of <em>Ixodes</em> ticks, the natural infection and the transmission dynamics of <em>Borrelia</em> species in this country.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 1","pages":"Article 100093"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000078/pdfft?md5=06d39c71ab063374656042c0958c561c&pid=1-s2.0-S2772431X24000078-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140052411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Infectious Medicine is becoming a globally high-level scientific journal 感染医学》正在成为全球高水平的科学杂志
Pub Date : 2024-03-01 DOI: 10.1016/j.imj.2024.100091
Xue-Jie Yu
{"title":"The Infectious Medicine is becoming a globally high-level scientific journal","authors":"Xue-Jie Yu","doi":"10.1016/j.imj.2024.100091","DOIUrl":"10.1016/j.imj.2024.100091","url":null,"abstract":"","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 1","pages":"Article 100091"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000054/pdfft?md5=b527359b8a0393f23cdbe396e4b10bfb&pid=1-s2.0-S2772431X24000054-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139965834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Infectious Medicine
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1