Infectious Medicine最新文献

英文中文

Diagnostic and prognostic value of disulfidptosis-related genes in sepsis 败血症中与二硫化硫相关基因的诊断和预后价值

Infectious Medicine

Pub Date : 2024-10-17 DOI: 10.1016/j.imj.2024.100143

Wenlu Zou, Lintao Sai, Wen Sai, Li Song, Gang Wang

Background

Sepsis is a disease associated with high morbidity and mortality rates, especially among the elderly and patients in intensive care units. Disulfidptosis, a newly identified form of cell death triggered by disulfide stress, is emerging as a significant factor in disease progression. This study aimed to explore the diagnostic and prognostic value of disulfidptosis-related genes in sepsis.

Methods

We obtained two datasets from the Gene Expression Omnibus (GEO) database to conduct our analysis. Functional enrichment analysis was performed to identify relevant biological pathways. A protein-protein interaction network was constructed to identify hub genes critical to sepsis. Additionally, we analyzed the immune infiltration status in sepsis patients. The diagnostic value of these hub genes for sepsis was evaluated using nomograms, receiver operating characteristic (ROC) curves, and calibration curves in both training and validation datasets. Finally, a miRNA-immune-related hub genes (miRNA-IHGs) regulatory network was developed to elucidate the synergistic interactions between miRNAs and their target genes.

Results

A total of 3,469 differentially expressed genes (DEGs) were identified, of which seven were related to disulfidptosis (DR-DEGs). Functional enrichment analysis showed that DR-DEGs were significantly enriched in pathways related to actin dynamics. Five hub genes (MYH10, ACTN4, MYH9, FLNA, and IQGAP1) were identified as central to these processes. The analysis of immune infiltration revealed significantly lower levels of 11 immune cell types, while macrophages and regulatory T cells were significantly elevated in sepsis patients. The area under the ROC curves (AUCs) of the IHGs risk prediction model were 0.917 and 0.894 for the training and validation sets, respectively. A miRNA-IHGs regulatory network, comprising 17 nodes and 27 edges, was constructed, with MYH9 being the most frequently regulated by miRNAs.

Conclusion

The pathophysiological process of sepsis appears to involve disulfidptosis, highlighting it as a potential new therapeutic targets for sepsis management.

背景败血症是一种发病率和死亡率都很高的疾病，尤其是在老年人和重症监护病房的病人中。二硫化物中毒是一种新发现的由二硫化物应激引发的细胞死亡形式，正在成为疾病进展的一个重要因素。本研究旨在探讨脓毒症中与二硫化物中毒相关基因的诊断和预后价值。我们进行了功能富集分析，以确定相关的生物学通路。我们构建了一个蛋白质-蛋白质相互作用网络，以确定对败血症至关重要的枢纽基因。此外，我们还分析了败血症患者的免疫浸润状态。在训练数据集和验证数据集中，我们使用提名图、接收者操作特征曲线（ROC）和校准曲线评估了这些枢纽基因对败血症的诊断价值。最后，研究人员建立了一个 miRNA-免疫相关枢纽基因（miRNA-IHGs）调控网络，以阐明 miRNA 与其靶基因之间的协同作用。功能富集分析表明，DR-DEGs 在肌动蛋白动力学相关通路中显著富集。五个中心基因（MYH10、ACTN4、MYH9、FLNA 和 IQGAP1）被确定为这些过程的中心基因。对免疫浸润的分析表明，脓毒症患者体内 11 种免疫细胞类型的水平明显降低，而巨噬细胞和调节性 T 细胞则明显升高。IHGs风险预测模型的训练集和验证集的ROC曲线下面积（AUC）分别为0.917和0.894。结论脓毒症的病理生理过程似乎涉及二硫化血症，这突出表明二硫化血症是脓毒症治疗的潜在新靶点。

{"title":"Diagnostic and prognostic value of disulfidptosis-related genes in sepsis","authors":"Wenlu Zou, Lintao Sai, Wen Sai, Li Song, Gang Wang","doi":"10.1016/j.imj.2024.100143","DOIUrl":"10.1016/j.imj.2024.100143","url":null,"abstract":"<div><h3>Background</h3><div>Sepsis is a disease associated with high morbidity and mortality rates, especially among the elderly and patients in intensive care units. Disulfidptosis, a newly identified form of cell death triggered by disulfide stress, is emerging as a significant factor in disease progression. This study aimed to explore the diagnostic and prognostic value of disulfidptosis-related genes in sepsis.</div></div><div><h3>Methods</h3><div>We obtained two datasets from the Gene Expression Omnibus (GEO) database to conduct our analysis. Functional enrichment analysis was performed to identify relevant biological pathways. A protein-protein interaction network was constructed to identify hub genes critical to sepsis. Additionally, we analyzed the immune infiltration status in sepsis patients. The diagnostic value of these hub genes for sepsis was evaluated using nomograms, receiver operating characteristic (ROC) curves, and calibration curves in both training and validation datasets. Finally, a miRNA-immune-related hub genes (miRNA-IHGs) regulatory network was developed to elucidate the synergistic interactions between miRNAs and their target genes.</div></div><div><h3>Results</h3><div>A total of 3,469 differentially expressed genes (DEGs) were identified, of which seven were related to disulfidptosis (DR-DEGs). Functional enrichment analysis showed that DR-DEGs were significantly enriched in pathways related to actin dynamics. Five hub genes (MYH10, ACTN4, MYH9, FLNA, and IQGAP1) were identified as central to these processes. The analysis of immune infiltration revealed significantly lower levels of 11 immune cell types, while macrophages and regulatory T cells were significantly elevated in sepsis patients. The area under the ROC curves (AUCs) of the IHGs risk prediction model were 0.917 and 0.894 for the training and validation sets, respectively. A miRNA-IHGs regulatory network, comprising 17 nodes and 27 edges, was constructed, with MYH9 being the most frequently regulated by miRNAs.</div></div><div><h3>Conclusion</h3><div>The pathophysiological process of sepsis appears to involve disulfidptosis, highlighting it as a potential new therapeutic targets for sepsis management.</div></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 4","pages":"Article 100143"},"PeriodicalIF":0.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142652647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple-site decontamination in critically ill patients requires careful implementation 重症患者的多部位净化需要谨慎实施

Infectious Medicine

Pub Date : 2024-10-16 DOI: 10.1016/j.imj.2024.100142

Yuetian Yu , Bin Lin , Lihui Wang , Chunhui Xu , Cheng Zhu , Yuan Gao

The EPIC III study showed that 52% of patients admitted to the intensive care unit (ICU) have infectious diseases and that the incidence of ICU-acquired infections is increasing, leading to longer ICU stays and higher mortality rates. Multiple-site decontamination, a type of selective decontamination program, has been associated with a reduction in the incidence of ICU-acquired infection and decreased mortality rates in some critically ill patients. However, the standardized implementation and actual effectiveness of multiple-site decontamination require further investigation.

EPIC III 研究表明，重症监护室（ICU）收治的病人中有 52% 患有感染性疾病，重症监护室获得性感染的发病率正在上升，导致重症监护室住院时间延长和死亡率升高。多部位净化是一种选择性净化计划，与降低重症监护室获得性感染的发病率和降低一些重症患者的死亡率有关。然而，多部位净化的标准化实施和实际效果还需要进一步研究。

引用次数: 0

Neurorestorative therapeutic strategies for sequela of central nervous system infections 中枢神经系统感染后遗症的神经恢复治疗策略

Infectious Medicine

Pub Date : 2024-10-11 DOI: 10.1016/j.imj.2024.100141

Hongyun Huang , Paul R. Sanberg , Hari Shanker Sharma

引用次数: 0

Diagnostic challenges and eponyms in tuberculous arthritis 结核性关节炎的诊断难题和外来名称

Infectious Medicine

Pub Date : 2024-09-26 DOI: 10.1016/j.imj.2024.100139

Jacob Draves , Halil Tekiner , Steven H. Yale , Eileen S. Yale

引用次数: 0

Brain fog across the Mediterranean 横跨地中海的脑雾

Infectious Medicine

Pub Date : 2024-09-26 DOI: 10.1016/j.imj.2024.100140

Souheil Zayet

引用次数: 0

Characterization of isoniazid resistance and genetic mutations in isoniazid-resistant and rifampicin-susceptible Mycobacterium tuberculosis in China 中国耐异烟肼结核分枝杆菌和易感利福平结核分枝杆菌的异烟肼耐药性和基因突变特征

Infectious Medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.imj.2024.100129

Dongxin Liu , Bing Zhao , Yang Zheng , Xichao Ou , Shengfen Wang , Yang Zhou , Yuanyuan Song , Hui Xia , Qiang Wei , YanLin Zhao

Background

Patients with tuberculosis resistant to isoniazid but susceptible to rifampicin (H^r-R^s TB) remain a neglected demographic, despite a high disease burden and poor outcomes of these patients. The aim of this study was to investigate the characteristics of isoniazid-resistance-related mutations in Mycobacterium tuberculosis and resistance rates to drugs included in WHO-recommended regimens for H^r-R^s patients.

Methods

Mycobacterium tuberculosis isolates (n = 4922) obtained from national tuberculosis drug-resistance surveillance were subjected to whole-genome sequencing to identify H^r-R^s strains. The minimal inhibitory concentrations (MICs) were established for the H^r-R^s strains to determine the isoniazid resistance levels. We also identified drug-resistance-associated mutations for five drugs (fluoroquinolones, ethambutol, pyrazinamide, streptomycin, and amikacin) in the H^r-R^s strains.

Results

Of the 4922 strains, 384 (7.8 %) were H^r-R^s. The subculture of seven strains failed, so 377 (98.2 %) strains underwent phenotypic MIC testing. Among the 384 genotypic H^r-R^s strains, 242 (63.0 %) contained the katG Ser315Thr substitution; 115 (29.9 %) contained the -15C>T in the promoter region of the fabG1 gene; and 16 (4.2 %) contained Ser315Asn in the katG gene. Of the 239 strains with the Ser315Thr substitution, 229 (95.8 %) had MIC ≥ 2 µg/mL, and of the 114 strains with the -15C>T mutation, 103 (90.4 %) had 0.25 µg/mL ≤ MIC ≤ 1 µg/mL. The genotypic resistance rates were 0.8 % (3/384) for pyrazinamide, 2.3 % (9/384) for ethambutol and fluoroquinolones; 39.6 % (152/384) of the strains were resistant to streptomycin, but only 0.5 % (2/384) of the strains were resistant to amikacin.

Conclusion

Ser315Thr in katG was the predominant mutation conferring the H^r-R^s phenotype, followed by the fabG1 -15C>T mutation. The combination of rifampicin, pyrazinamide, ethambutol, and levofloxacin should be effective in the treatment of patients with H^r-R^s tuberculosis because the resistance rates for these drugs in China are low.

背景对异烟肼耐药但对利福平易感的结核病（Hr-Rs TB）患者仍然是一个被忽视的人群，尽管这些患者的疾病负担很重，治疗效果很差。本研究旨在调查结核分枝杆菌中与异烟肼耐药性相关的突变特征，以及对世界卫生组织推荐的Hr-Rs患者治疗方案中所含药物的耐药率。方法对从全国结核病耐药性监测中获得的结核分枝杆菌分离株（n = 4922）进行全基因组测序，以确定Hr-Rs菌株。我们确定了 Hr-Rs 菌株的最小抑菌浓度 (MIC)，以确定其对异烟肼的耐药性水平。我们还在 Hr-Rs 菌株中发现了五种药物（氟喹诺酮类、乙胺丁醇、吡嗪酰胺、链霉素和阿米卡星）的耐药性相关突变。7 株菌株的亚培养失败，因此对 377 株（98.2%）菌株进行了表型 MIC 检测。在 384 株基因型 Hr-Rs 菌株中，242 株（63.0%）含有 katG Ser315Thr 替换；115 株（29.9%）在 fabG1 基因启动子区域含有 -15C>T；16 株（4.2%）在 katG 基因中含有 Ser315Asn。在239株含有Ser315Thr替换的菌株中，229株（95.8%）的MIC≥2 µg/mL，而在114株含有-15C>T突变的菌株中，103株（90.4%）的MIC为0.25 µg/mL ≤ 1 µg/mL。基因型耐药率为：吡嗪酰胺 0.8 %（3/384），乙胺丁醇和氟喹诺酮 2.3 %（9/384）；39.6 %（152/384）的菌株对链霉素耐药，但只有 0.结论 katG中的Ser315Thr是产生Hr-Rs表型的主要突变，其次是fabG1 -15C>T突变。由于利福平、吡嗪酰胺、乙胺丁醇和左氧氟沙星这四种药物在中国的耐药率较低，因此这四种药物的联合应用应能有效治疗Hr-Rs肺结核患者。

{"title":"Characterization of isoniazid resistance and genetic mutations in isoniazid-resistant and rifampicin-susceptible Mycobacterium tuberculosis in China","authors":"Dongxin Liu , Bing Zhao , Yang Zheng , Xichao Ou , Shengfen Wang , Yang Zhou , Yuanyuan Song , Hui Xia , Qiang Wei , YanLin Zhao","doi":"10.1016/j.imj.2024.100129","DOIUrl":"10.1016/j.imj.2024.100129","url":null,"abstract":"<div><h3>Background</h3><p>Patients with tuberculosis resistant to isoniazid but susceptible to rifampicin (H<sup>r</sup>-R<sup>s</sup> TB) remain a neglected demographic, despite a high disease burden and poor outcomes of these patients. The aim of this study was to investigate the characteristics of isoniazid-resistance-related mutations in <em>Mycobacterium tuberculosis</em> and resistance rates to drugs included in WHO-recommended regimens for H<sup>r</sup>-R<sup>s</sup> patients.</p></div><div><h3>Methods</h3><p><em>Mycobacterium tuberculosis</em> isolates (<em>n</em> = 4922) obtained from national tuberculosis drug-resistance surveillance were subjected to whole-genome sequencing to identify H<sup>r</sup>-R<sup>s</sup> strains. The minimal inhibitory concentrations (MICs) were established for the H<sup>r</sup>-R<sup>s</sup> strains to determine the isoniazid resistance levels. We also identified drug-resistance-associated mutations for five drugs (fluoroquinolones, ethambutol, pyrazinamide, streptomycin, and amikacin) in the H<sup>r</sup>-R<sup>s</sup> strains.</p></div><div><h3>Results</h3><p>Of the 4922 strains, 384 (7.8 %) were H<sup>r</sup>-R<sup>s</sup>. The subculture of seven strains failed, so 377 (98.2 %) strains underwent phenotypic MIC testing. Among the 384 genotypic H<sup>r</sup>-R<sup>s</sup> strains, 242 (63.0 %) contained the <em>katG</em> Ser315Thr substitution; 115 (29.9 %) contained the -15C>T in the promoter region of the <em>fabG1</em> gene; and 16 (4.2 %) contained Ser315Asn in the <em>katG</em> gene. Of the 239 strains with the Ser315Thr substitution, 229 (95.8 %) had MIC ≥ 2 µg/mL, and of the 114 strains with the -15C>T mutation, 103 (90.4 %) had 0.25 µg/mL ≤ MIC ≤ 1 µg/mL. The genotypic resistance rates were 0.8 % (3/384) for pyrazinamide, 2.3 % (9/384) for ethambutol and fluoroquinolones; 39.6 % (152/384) of the strains were resistant to streptomycin, but only 0.5 % (2/384) of the strains were resistant to amikacin.</p></div><div><h3>Conclusion</h3><p>Ser315Thr in <em>katG</em> was the predominant mutation conferring the H<sup>r</sup>-R<sup>s</sup> phenotype, followed by the <em>fabG1</em> -15C>T mutation. The combination of rifampicin, pyrazinamide, ethambutol, and levofloxacin should be effective in the treatment of patients with H<sup>r</sup>-R<sup>s</sup> tuberculosis because the resistance rates for these drugs in China are low.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 3","pages":"Article 100129"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000431/pdfft?md5=26b8dfceffc196520c45425a907da6a7&pid=1-s2.0-S2772431X24000431-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular tuberculosis associated with Epstein-Barr virus myelitis: A case report 伴有 Epstein-Barr 病毒脊髓炎的眼结核：病例报告

Infectious Medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.imj.2024.100132

Fakhri Alahyari , Raheleh Halabian , Javad Hosseini Nejad

Ocular tuberculosis (OTB) is a chronic eye infection caused by Mycobacterium tuberculosis. Some cases of myelitis are associated with Epstein-Barr virus (EBV), with 1-5% of EBV infections leading to neurologic complications. We describe a 34-year-old Iranian woman with OTB and EBV coinfection. Despite initial success with anti-TB agents, the disease progressed, necessitating enucleation. Mycobacterium tuberculosis was detected by a tuberculin coagulation test, and EBV was confirmed via polymerase chain reaction. MRI showed plaques in the spinal cord and brain. The patient was treated with anti-TB and antiretroviral agents. Recognizing TB in the differential diagnosis of EBV myelitis is crucial.

眼结核病（OTB）是由结核分枝杆菌引起的慢性眼部感染。有些脊髓炎病例与爱泼斯坦-巴氏病毒（EBV）有关，1%-5%的 EBV 感染会导致神经系统并发症。我们描述了一名 34 岁伊朗妇女的 OTB 和 EBV 合并感染病例。尽管最初使用抗结核药物取得了成功，但病情仍在发展，不得不进行去核手术。通过结核菌素凝集试验检测出结核分枝杆菌，聚合酶链反应证实了 EBV。核磁共振成像显示脊髓和大脑中有斑块。患者接受了抗结核和抗逆转录病毒药物治疗。在 EB 病毒脊髓炎的鉴别诊断中识别结核病至关重要。

引用次数: 0

Epidemiological characteristics of ventilator-associated pneumonia in neurosurgery: A 10-year surveillance study in a Chinese tertiary hospital 神经外科呼吸机相关肺炎的流行病学特征：一家中国三级医院的十年监测研究

Infectious Medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.imj.2024.100128

Zhenghao Yu , Xinlou Li , Chenglong Lv , Yao Tian , Jijiang Suo , Zhongqiang Yan , Yanling Bai , Bowei Liu , Liqun Fang , Mingmei Du , Hongwu Yao , Yunxi Liu

Background

Ventilator-associated pneumonia (VAP) is a significant and common health concern. The epidemiological landscape of VAP is poorly understood in neurosurgery patients. This study aimed to explore the epidemiology of VAP in this population and devise targeted surveillance, treatment, and control efforts.

Methods

A 10-year retrospective study spanning 2011 to 2020 was performed in a large Chinese tertiary hospital. Surveillance data was collected from neurosurgical patients and analyzed to map the demographic and clinical characteristics of VAP and describe the distribution and antimicrobial resistance profile of leading pathogens. Risk factors associated with the presence of VAP were explored using boosted regression tree (BRT) models.

Results

Three hundred ten VAP patients were identified. The 10-year incidence of VAP was 16.21 per 1000 ventilation days. All-cause mortality was 6.1%. The prevalence of gram-negative bacteria, fungi, and gram-positive bacteria among the 357 organisms isolated from VAP patients was 86.0%, 7.6%, and 6.4%, respectively; most were multidrug-resistant organisms. Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa were the most common pathogens. The prevalence of carbapenem-resistant A. baumannii, P. aeruginosa, and K. pneumoniae was high and increased over time in the study period. The BRT models revealed that VAP was associated with number of days of ventilator use (relative contribution, 47.84 ± 7.25), Glasgow Coma Scale score (relative contribution, 24.72 ± 5.67), and tracheotomy (relative contribution, 21.50 ± 2.69).

Conclusions

Our findings provide a better understanding of the epidemiology of VAP and its risk factors in neurosurgery patients.

背景呼吸机相关性肺炎（VAP）是一个重要而常见的健康问题。人们对神经外科患者中 VAP 的流行病学情况知之甚少。本研究旨在探索 VAP 在这一人群中的流行病学，并制定有针对性的监测、治疗和控制措施。研究收集了神经外科患者的监测数据，并通过分析这些数据绘制了VAP的人口统计学和临床特征图，描述了主要病原体的分布和抗菌药物耐药性概况。结果发现了310名VAP患者。VAP 的 10 年发病率为每 1000 个通气日 16.21 例。全因死亡率为 6.1%。在从 VAP 患者体内分离出的 357 种微生物中，革兰氏阴性菌、真菌和革兰氏阳性菌的流行率分别为 86.0%、7.6% 和 6.4%；其中大多数为耐多药微生物。鲍曼不动杆菌、肺炎克雷伯菌和铜绿假单胞菌是最常见的病原体。研究期间，耐碳青霉烯类鲍曼不动杆菌、铜绿假单胞菌和肺炎克雷伯菌的发病率较高，且随着时间的推移而增加。BRT 模型显示，VAP 与呼吸机使用天数（相对贡献率为 47.84 ± 7.25）、格拉斯哥昏迷量表评分（相对贡献率为 24.72 ± 5.67）和气管切开术（相对贡献率为 21.50 ± 2.69）有关。

{"title":"Epidemiological characteristics of ventilator-associated pneumonia in neurosurgery: A 10-year surveillance study in a Chinese tertiary hospital","authors":"Zhenghao Yu , Xinlou Li , Chenglong Lv , Yao Tian , Jijiang Suo , Zhongqiang Yan , Yanling Bai , Bowei Liu , Liqun Fang , Mingmei Du , Hongwu Yao , Yunxi Liu","doi":"10.1016/j.imj.2024.100128","DOIUrl":"10.1016/j.imj.2024.100128","url":null,"abstract":"<div><h3>Background</h3><p>Ventilator-associated pneumonia (VAP) is a significant and common health concern. The epidemiological landscape of VAP is poorly understood in neurosurgery patients. This study aimed to explore the epidemiology of VAP in this population and devise targeted surveillance, treatment, and control efforts.</p></div><div><h3>Methods</h3><p>A 10-year retrospective study spanning 2011 to 2020 was performed in a large Chinese tertiary hospital. Surveillance data was collected from neurosurgical patients and analyzed to map the demographic and clinical characteristics of VAP and describe the distribution and antimicrobial resistance profile of leading pathogens. Risk factors associated with the presence of VAP were explored using boosted regression tree (BRT) models.</p></div><div><h3>Results</h3><p>Three hundred ten VAP patients were identified. The 10-year incidence of VAP was 16.21 per 1000 ventilation days. All-cause mortality was 6.1%. The prevalence of gram-negative bacteria, fungi, and gram-positive bacteria among the 357 organisms isolated from VAP patients was 86.0%, 7.6%, and 6.4%, respectively; most were multidrug-resistant organisms. <em>Acinetobacter baumannii, Klebsiella pneumoniae</em>, and <em>Pseudomonas aeruginosa</em> were the most common pathogens. The prevalence of carbapenem-resistant <em>A. baumannii, P. aeruginosa,</em> and <em>K. pneumoniae</em> was high and increased over time in the study period. The BRT models revealed that VAP was associated with number of days of ventilator use (relative contribution, 47.84 ± 7.25), Glasgow Coma Scale score (relative contribution, 24.72 ± 5.67), and tracheotomy (relative contribution, 21.50 ± 2.69).</p></div><div><h3>Conclusions</h3><p>Our findings provide a better understanding of the epidemiology of VAP and its risk factors in neurosurgery patients.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 3","pages":"Article 100128"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X2400042X/pdfft?md5=1f910e6f40248a5c95744cd1bd21f27c&pid=1-s2.0-S2772431X2400042X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The key mechanisms of multi-system responses triggered by central nervous system damage in hand, foot, and mouth disease severity 手足口病严重程度中枢神经系统损伤引发多系统反应的关键机制

Infectious Medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.imj.2024.100124

Wangquan Ji, Peiyu Zhu, Yuexia Wang, Yu Zhang, Zijie Li, Haiyan Yang, Shuaiyin Chen, Yuefei Jin, Guangcai Duan

Hand, foot, and mouth disease (HFMD) is a prevalent infectious affliction primarily affecting children, with a small portion of cases progressing to neurological complications. Notably, in a subset of severe HFMD cases, neurological manifestations may result in significant sequelae and pose a risk of mortality. We systematically conducted literature retrieval from the databases PubMed (1957–2023), Embase (1957–2023), and Web of Science (1957–2023), in addition to consulting authoritative guidelines. Subsequently, we rigorously selected the most relevant articles within the scope of this review for comprehensive analysis. It is widely recognized that the severity of HFMD is attributed to a multifaceted array of pathophysiological mechanisms. The implication of multi-system dysfunction appears to be perturbances of the human defense system; therefore, it contributes to the severity of HFMD. In this review, we provide an overview and analysis of recent insights into the molecular mechanisms contributing to the severity of HFMD, with a particular focus on cytokine release syndrome, the involvement of the renin-angiotensin system, regional immunity, endothelial dysfunction, catecholamine storm, viral invasion, and the molecular mechanisms of neurological damage. We speculate that the domino effect of diverse physiological systems, initiated by damage to the central nervous system, serve as the primary mechanisms governing the severity of HFMD. Simultaneously, we emphasize the knowledge gaps and research urgently required to delineate a quick roadmap for ongoing and essential studies on HFMD.

手足口病（HFMD）是一种主要影响儿童的流行性传染病，一小部分病例会发展为神经系统并发症。值得注意的是，在一部分严重的手足口病病例中，神经系统表现可能会导致严重的后遗症并带来死亡风险。除参考权威指南外，我们还从 PubMed（1957-2023 年）、Embase（1957-2023 年）和 Web of Science（1957-2023 年）数据库中进行了系统的文献检索。随后，我们严格挑选了本综述范围内最相关的文章进行综合分析。人们普遍认为，手足口病的严重程度归因于一系列多方面的病理生理机制。多系统功能障碍的含义似乎是人体防御系统受到干扰，因此导致了手足口病的严重性。在本综述中，我们概述并分析了导致手足口病严重程度的分子机制的最新见解，尤其关注细胞因子释放综合征、肾素-血管紧张素系统的参与、区域免疫、内皮功能障碍、儿茶酚胺风暴、病毒入侵以及神经损伤的分子机制。我们推测，由中枢神经系统损伤引发的各种生理系统的多米诺骨牌效应是手足口病严重程度的主要影响机制。同时，我们强调了知识差距和迫切需要开展的研究，以便为手足口病的持续和必要研究绘制快速路线图。

{"title":"The key mechanisms of multi-system responses triggered by central nervous system damage in hand, foot, and mouth disease severity","authors":"Wangquan Ji, Peiyu Zhu, Yuexia Wang, Yu Zhang, Zijie Li, Haiyan Yang, Shuaiyin Chen, Yuefei Jin, Guangcai Duan","doi":"10.1016/j.imj.2024.100124","DOIUrl":"10.1016/j.imj.2024.100124","url":null,"abstract":"<div><p>Hand, foot, and mouth disease (HFMD) is a prevalent infectious affliction primarily affecting children, with a small portion of cases progressing to neurological complications. Notably, in a subset of severe HFMD cases, neurological manifestations may result in significant sequelae and pose a risk of mortality. We systematically conducted literature retrieval from the databases PubMed (1957–2023), Embase (1957–2023), and Web of Science (1957–2023), in addition to consulting authoritative guidelines. Subsequently, we rigorously selected the most relevant articles within the scope of this review for comprehensive analysis. It is widely recognized that the severity of HFMD is attributed to a multifaceted array of pathophysiological mechanisms. The implication of multi-system dysfunction appears to be perturbances of the human defense system; therefore, it contributes to the severity of HFMD. In this review, we provide an overview and analysis of recent insights into the molecular mechanisms contributing to the severity of HFMD, with a particular focus on cytokine release syndrome, the involvement of the renin-angiotensin system, regional immunity, endothelial dysfunction, catecholamine storm, viral invasion, and the molecular mechanisms of neurological damage. We speculate that the domino effect of diverse physiological systems, initiated by damage to the central nervous system, serve as the primary mechanisms governing the severity of HFMD. Simultaneously, we emphasize the knowledge gaps and research urgently required to delineate a quick roadmap for ongoing and essential studies on HFMD.</p></div>","PeriodicalId":100667,"journal":{"name":"Infectious Medicine","volume":"3 3","pages":"Article 100124"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772431X24000388/pdfft?md5=2b2e2b5d4be2f60135fec4e6e10cfeab&pid=1-s2.0-S2772431X24000388-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141842178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infectious intracranial aneurysm associated with Lactococcus garvieae: A case report and literature review 与加维氏乳球菌相关的感染性颅内动脉瘤：病例报告和文献综述

Infectious Medicine

Pub Date : 2024-09-01 DOI: 10.1016/j.imj.2024.100123

Chung-Ho Lee , Peter Yat-Ming Woo , Calvin Ka-Lam Leung , Ronald Li , Jenny Kwan-Tsz Chan , Kwan-Shun Ng , Cindy Wing-Sze Tse

Lactococcus garvieae is a known fish pathogen associated with numerous aquacultural outbreaks. In humans, L. garvieae primarily causes infective endocarditis, but infections involving other organs have also been reported. We report the first case of ruptured infectious intracranial aneurysm associated with L. garvieae bacteraemia without concomitant infective endocarditis. The diagnosis of a left distal posterior cerebral artery mycotic aneurysm was based on a computed tomography angiogram, catheter angiogram and histopathological examination of the resected aneurysm. Here, we review the literature on human L. garvieae infections and describe the clinical characteristics, risk factors, management and outcomes of the cases identified to date.

加维氏乳球菌（Lactococcus garvieae）是一种已知的鱼类病原体，曾多次在水产养殖业中爆发。在人类中，L. garvieae 主要引起感染性心内膜炎，但也有涉及其他器官感染的报道。我们报告了首例与加维氏梭菌菌血症相关的感染性颅内动脉瘤破裂病例，该病例未同时伴有感染性心内膜炎。根据计算机断层扫描血管造影、导管血管造影和切除动脉瘤的组织病理学检查，诊断为左侧大脑后动脉远端霉菌性动脉瘤。在此，我们回顾了有关人类L. garvieae感染的文献，并描述了迄今发现的病例的临床特征、风险因素、管理和结果。

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Infectious Medicine

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀