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A rare presentation of Horner's syndrome following cervical epidural steroid injection 宫颈硬膜外类固醇注射后出现罕见的霍纳氏综合征
Pub Date : 2025-09-01 Epub Date: 2025-07-29 DOI: 10.1016/j.inpm.2025.100615
Charles J. Mazof , Derek H. Bui , Musa M. Aner
Horner's syndrome is a clinically significant condition caused by disruption of the oculosympathetic nerve pathway, typically presenting with ptosis, miosis, and facial anhidrosis. It can result from serious, life-threatening conditions such as trauma, carotid artery dissection, or malignancy; however, it may also arise from iatrogenic reasons, including stellate ganglion blocks, by other surgical interventions of the head and neck. While exceedingly rare, Horner's syndrome has been reported to occur after a cervical epidural steroid injection. Given the various potential etiologies of Horner's syndrome, prompt evaluation is required to rule out life-threatening conditions in the setting of an acute and unexpected presentation.
This case study describes a presentation of Horner's syndrome following a cervical epidural steroid injection (ESI) for a cervical radiculopathy. Due to the unusual nature, a serious cerebrovascular event was initially considered and urgent evaluation was advised. Fortunately, all symptoms resolved fully within two hours without medical intervention. It has been suggested that local anesthetic diffusion to the preganglionic neurons caused pharmacologic disruption of the sympathetic fibers. This case provides additional evidence to the limited reports of Horner's syndrome after cervical epidurals. It also highlights the importance of minimizing or forgoing local anesthetics, considering non-particulate steroids, and conducting emergent evaluation for new onset of neurological deficits during or after cervical ESIs.
霍纳综合征是由眼交感神经通路破坏引起的一种临床重要疾病,典型表现为上睑下垂、瞳孔缩小和面部无汗。它可以由严重的、危及生命的情况引起,如创伤、颈动脉夹层或恶性肿瘤;然而,它也可能由医源性原因引起,包括星状神经节阻滞,通过其他头颈部手术干预。虽然极为罕见,但据报道,在宫颈硬膜外类固醇注射后发生霍纳综合征。鉴于霍纳综合征的各种潜在病因,需要及时评估,以排除危及生命的条件下设置的急性和意外的表现。本病例研究描述了霍纳综合征的表现后,硬膜外类固醇注射(ESI)颈椎神经根病。由于不寻常的性质,最初认为是严重的脑血管事件,建议紧急评估。幸运的是,在没有医疗干预的情况下,所有症状在两小时内完全消失。有人认为,局部麻醉扩散到神经节前神经元引起交感神经纤维的药理学破坏。本病例为有限的宫颈硬膜外硬膜后霍纳综合征的报道提供了额外的证据。它还强调了减少或放弃局部麻醉的重要性,考虑非颗粒类固醇,并在颈椎穿刺期间或之后对新发作的神经功能缺损进行紧急评估。
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引用次数: 0
Hematoma formation after basivertebral nerve ablation 基底神经消融后形成血肿
Pub Date : 2025-09-01 Epub Date: 2025-07-30 DOI: 10.1016/j.inpm.2025.100617
Sean Fox , Joshua Levin
Basivertebral nerve ablation (BVNA) has been shown to have significant and lasting effects on chronic vertebrogenic low back pain. Serious complications have been rare, including hematoma formation. However, given that the target lesion occurs at the basivertebral foramen, which not only houses the basivertebral nerve terminus but also the basivertebral vessels, hematoma formation is theoretically plausible. This case demonstrates a suspected hematoma in the extradural neural axis compartment following BVNA. The patient was treated conservatively and there were no significant lasting adverse effects.
基底神经消融(BVNA)已被证明对慢性椎源性腰痛有显著和持久的影响。严重的并发症很少见,包括血肿的形成。然而,鉴于目标病变发生在基底孔,基底孔不仅包含椎神经末梢,还包含椎血管,因此血肿形成在理论上是合理的。本病例表现为BVNA后硬膜外神经轴室疑似血肿。患者接受保守治疗,无明显的持续不良反应。
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引用次数: 0
Safety and effectiveness of basivertebral nerve ablation in patients with osteoporosis and osteopenia: A real-world study 椎体神经消融治疗骨质疏松和骨质减少患者的安全性和有效性:一项真实世界的研究
Pub Date : 2025-09-01 Epub Date: 2025-08-14 DOI: 10.1016/j.inpm.2025.100624
Emily Bellow, Derek Johnson, Sandi Bajrami, William Caldwell

Background

The Intracept procedure was the first FDA-cleared technique for basivertebral nerve ablation, a minimally invasive treatment for vertebrogenic chronic low back pain. While prior studies support its effectiveness, data in patients with osteoporosis and osteopenia remains limited.

Objective

To evaluate the safety and effectiveness of basivertebral nerve ablation with a specific focus on pain reduction, functional improvement, and the incidence of post-procedure vertebral compression fractures.

Methods

A retrospective chart review was conducted on patients who underwent the Intracept procedure at our institution from November 2019 to January 2025. Bone density status was categorized using available DEXA scans. Patients were stratified into a Reduced Bone Density group (N = 32), consisting of 23 patients with osteopenia and 9 with osteoporosis, and the overall cohort (N = 134). Pain severity was assessed using the Visual Analog Scale (VAS) at baseline and at the 4–6-week post-procedure follow-up visit, and functional improvement was determined based on patient-reported outcomes at the same time point. Post-procedure complications, including vertebral compression fractures, were monitored until the most recent available follow-up.

Results

A significant decrease in VAS was observed for the overall cohort (7.04 vs. 3.78, p < 0.001) and the Reduced Bone Density group (6.75 vs. 4.13, p < 0.001). Functional improvement was reported by 79.1 % of patients in the overall study population and 78.1 % of patients in the Reduced Bone Density group. No post-procedure vertebral compression fractures were observed in the entire cohort, with a mean follow-up length of 18.07 months.

Conclusion

The Intracept procedure demonstrated significant pain reduction and functional improvement in the overall cohort and in patients with reduced bone density. Notably, no post-procedure vertebral compression fractures were observed, even in patients with osteoporosis and osteopenia. These findings contribute to the growing body of independent literature supporting the safety and effectiveness of the Intracept procedure and offer real-world insight into its use in patients with reduced bone density.
背景:该手术是首个获得fda批准的椎体神经消融技术,是一种治疗椎体源性慢性腰痛的微创治疗方法。虽然先前的研究支持其有效性,但骨质疏松症和骨质减少患者的数据仍然有限。目的评价基椎神经消融术的安全性和有效性,特别关注疼痛减轻、功能改善和术后椎体压缩性骨折的发生率。方法回顾性分析2019年11月至2025年1月在我院行内置管术的患者。使用DEXA扫描对骨密度状态进行分类。将患者分层分为骨密度降低组(N = 32),其中骨质减少组23例,骨质疏松组9例,整体队列(N = 134)。在基线和术后4 - 6周随访时使用视觉模拟量表(VAS)评估疼痛严重程度,并根据患者报告的同一时间点的结果确定功能改善情况。术后并发症,包括椎体压缩性骨折,一直监测到最近的随访。结果整个队列的VAS评分显著下降(7.04 vs. 3.78, p <;0.001)和骨密度降低组(6.75 vs. 4.13, p <;0.001)。总体研究人群中79.1%的患者和骨密度降低组中78.1%的患者报告功能改善。整个队列中未观察到术后椎体压缩性骨折,平均随访时间为18.07个月。结论:在整个队列和骨密度降低的患者中,截骨术显示出明显的疼痛减轻和功能改善。值得注意的是,即使在骨质疏松和骨质减少的患者中,也没有观察到术后椎体压缩性骨折。这些发现有助于越来越多的独立文献支持内截骨术的安全性和有效性,并为其在骨密度降低患者中的应用提供了真实的见解。
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引用次数: 0
Assessing the availability, readability, and content of online patient Education materials for cancer pain interventions: A cross-sectional analysis of major cancer center websites 评估癌症疼痛干预的在线患者教育材料的可用性、可读性和内容:对主要癌症中心网站的横断面分析
Pub Date : 2025-09-01 Epub Date: 2025-08-21 DOI: 10.1016/j.inpm.2025.100633
Meha Aggarwal , Marshall Yuan , David Hao

Background

As cancer survival improves, chronic cancer-related pain is an increasing clinical concern. Interventional procedures offer targeted, opioid-sparing pain relief, yet the quality and readability of online educational materials about these options remain poorly understood.

Objective

To evaluate the availability, quality, and readability of online educational resources on interventional cancer pain management available from National Cancer Institute (NCI)-designated cancer centers.

Methods

We conducted a cross-sectional analysis of 65 NCI-designated clinical cancer center websites to identify patient-facing content discussing interventional cancer pain procedures. Eligible materials were evaluated for quality using the DISCERN instrument and for readability using seven validated metrics. Inter-rater reliability was assessed using the intraclass correlation coefficient (ICC). Statistical comparisons were performed using t-tests.

Results

Only 20 of 65 cancer center websites (31%) contained relevant educational materials. Sixty qualifying texts were identified: 28 full articles and 32 substantial mentions (≥50 words). The mean DISCERN score was 37 ± 9, indicating poor quality. Articles scored significantly higher than substantial mentions (mean difference 9.4 points, p < 0.001). The ICC for DISCERN scores was 0.872 (p < 0.001), reflecting good inter-rater agreement. Readability analysis revealed an average reading level equivalent to the 11th grade across all metrics, significantly higher than the NIH-recommended 8th-grade level (p < 0.001). Substantial mentions were significantly more difficult to read than articles (p < 0.001).

Conclusions

Online materials on cancer pain interventions are generally scarce, low in quality, and written above nationally recommended reading levels. These findings highlight the need for cancer centers to improve online education materials using plain language and health literacy tools to better support informed decision-making.
随着癌症生存率的提高,慢性癌症相关疼痛越来越受到临床关注。介入手术提供有针对性的、不使用阿片类药物的疼痛缓解,但关于这些选择的在线教育材料的质量和可读性仍然知之甚少。目的评估美国国家癌症研究所(NCI)指定癌症中心提供的介入性癌症疼痛管理在线教育资源的可得性、质量和可读性。方法:我们对65个nci指定的临床癌症中心网站进行了横断面分析,以确定讨论介入性癌症疼痛手术的面向患者的内容。使用DISCERN仪器评估合格材料的质量,并使用七个经过验证的指标评估材料的可读性。采用类内相关系数(ICC)评估评估间信度。采用t检验进行统计学比较。结果65个癌症中心网站中只有20个(31%)包含相关的教育资料。确定了60篇符合条件的文章:28篇完整文章和32篇实质性提及(≥50字)。平均DISCERN评分为37±9分,表明质量较差。文章得分明显高于大量提及(平均差9.4分,p < 0.001)。DISCERN评分的ICC为0.872 (p < 0.001),反映了良好的评分间一致性。可读性分析显示,所有指标的平均阅读水平与11年级相当,显著高于美国国立卫生研究院推荐的8年级水平(p < 0.001)。实质性的提及明显比文章更难阅读(p < 0.001)。结论:关于癌症疼痛干预的在线资料普遍稀缺,质量低,且高于国家推荐阅读水平。这些发现强调了癌症中心需要改进在线教育材料,使用简单的语言和健康素养工具,以更好地支持知情决策。
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引用次数: 0
Mastering the GON Block: A practical four-step ultrasound-Guided approach 掌握GON块:一个实用的四步超声引导方法
Pub Date : 2025-09-01 Epub Date: 2025-06-24 DOI: 10.1016/j.inpm.2025.100605
Mustafa Turgut Yildizgoren , Hatice Ozeken , Abdulkadir Bartu , Fatih Bagcier
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引用次数: 0
Corrigendum to “Genicular nerve block with corticosteroid for chronic knee Pain: Patient-Reported outcomes across 9-years of practice” [Intervent Pain Med 4 (2025) 100601] “膝神经阻滞与皮质类固醇治疗慢性膝关节疼痛:患者报告的9年实践结果”的勘误表[介入疼痛医学4 (2025)100601]
Pub Date : 2025-09-01 Epub Date: 2025-06-25 DOI: 10.1016/j.inpm.2025.100602
Mingda Chen , Sercan Tosun , Nicolas R. Thompson , Kush K. Goyal
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引用次数: 0
ChatGPT and low back pain - Evaluating AI-driven patient education in the context of interventional pain medicine ChatGPT和腰痛——在介入性疼痛医学背景下评估人工智能驱动的患者教育
Pub Date : 2025-09-01 Epub Date: 2025-09-02 DOI: 10.1016/j.inpm.2025.100636
Ahmed Basharat , Rohan Shah , Nick Wilcox , Gurpaij Tur , Siddarth Tripati , Prisha Kansal , Niveah Gandhi , Sreekrishna Pokuri , Gabby Chong , Charles A. Odonkor , Narayana Varhabhatla , Robert Chow
<div><h3>Background</h3><div>ChatGPT and other Large Language Models (LLMs) are not only being more readily integrated into healthcare but are also being utilized more frequently by patients to answer health-related questions. Given the increased utilization for this purpose, it is essential to evaluate and study the consistency and reliability of artificial intelligence (AI) responses. Low back pain (LBP) remains one of the most frequently seen chief complaints in primary care and interventional pain management offices.</div></div><div><h3>Objective</h3><div>This study assesses the readability, accuracy, and overall utility of ChatGPT's ability to address patients' questions concerning low back pain. Our aim is to use clinician feedback to analyze ChatGPT's responses to these common low back pain related questions, as in the future, AI will undoubtedly play a role in triaging patients prior to seeing a physician.</div></div><div><h3>Methods</h3><div>To assess AI responses, we generated a standardized list of 25 questions concerning low back pain that were split into five categories including diagnosis, seeking a medical professional, treatment, self-treatment, and physical therapy. We explored the influence of how a prompt is worded on ChatGPT by asking questions from a 4th grader to a college/reference level. One board certified interventional pain specialist, one interventional pain fellow, and one emergency medicine resident reviewed ChatGPT's generated answers to assess accuracy and clinical utility. Readability and comprehensibility were evaluated using the Flesch-Kincaid Grade Level Scale. Statistical analysis was performed to analyze differences in readability scores, word count, and response complexity.</div></div><div><h3>Results</h3><div>How a question is phrased influences accuracy in statistically significant ways. Over-simplification of queries (e.g. to a 4th grade level) degrades ChatGPT's ability to return clinically complete responses. In contrast, reference and neutral queries preserve accuracy without additional engineering. Regardless of how the question is phrased, ChatGPT's default register trends towards technical language. Readability remains substantially misaligned with health literacy standards. Verbosity correlates with prompt type, but not necessarily accuracy. Word count is an unreliable proxy for informational completeness or clinical correctness in AI outputs and most errors stem from omission, not commission. Importantly, ChatGPT does not frequently generate false claims.</div></div><div><h3>Conclusion</h3><div>This analysis complicates the assumption that “simpler is better” in prompting LLMs for clinical education. Whereas earlier work in structured conditions suggested that plain-language prompts improved accuracy, our findings indicate that a moderate reading level, not maximal simplicity, yields the most reliable outputs in complex domains like pain. This study further supports that AI LLMs can be integrated
chatgpt和其他大型语言模型(llm)不仅更容易集成到医疗保健中,而且还被患者更频繁地用于回答与健康相关的问题。鉴于为此目的而增加的利用率,评估和研究人工智能(AI)响应的一致性和可靠性至关重要。腰痛(LBP)仍然是初级保健和介入性疼痛管理办公室最常见的主诉之一。目的本研究评估ChatGPT解决患者腰痛问题的可读性、准确性和整体效用。我们的目标是利用临床医生的反馈来分析ChatGPT对这些常见腰痛相关问题的反应,因为在未来,人工智能无疑将在看医生之前对患者进行分类。为了评估人工智能的反应,我们生成了一个包含25个关于腰痛问题的标准化列表,这些问题被分为五类,包括诊断、寻求医疗专业人员、治疗、自我治疗和物理治疗。我们通过询问从四年级学生到大学/参考水平的问题,探索了在ChatGPT上提示措辞的影响。一位委员会认证的介入性疼痛专家、一位介入性疼痛研究员和一位急诊医师审查了ChatGPT生成的答案,以评估其准确性和临床实用性。可读性和可理解性采用Flesch-Kincaid等级量表进行评价。进行统计分析,分析可读性评分、字数和反应复杂性的差异。结果问题的措辞对准确性的影响具有统计学意义。查询的过度简化(例如到4级水平)降低了ChatGPT返回临床完整回复的能力。相比之下,引用查询和中立查询无需额外的工程就能保持准确性。不管问题是如何表达的,ChatGPT的默认寄存器都倾向于技术语言。可读性仍然与卫生素养标准严重不一致。冗长与提示类型相关,但不一定准确。字数统计是人工智能输出信息完整性或临床正确性的不可靠代理,大多数错误源于遗漏,而不是委托。重要的是,ChatGPT不会经常生成虚假声明。结论该分析使“越简单越好”的假设在促使法学硕士进行临床教育方面变得复杂。尽管早期在结构化条件下的研究表明,简单的语言可以提高准确性,但我们的研究结果表明,中等阅读水平,而不是最大的简单性,在疼痛等复杂领域产生最可靠的输出。这项研究进一步支持人工智能法学硕士可以通过电子健康记录(EHR)软件集成到临床工作流程中。
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引用次数: 0
“Is this injection going to hurt?” Quantifying the pain experience during common lumbosacral spine injections “打针会痛吗?”腰骶椎注射时疼痛体验的量化
Pub Date : 2025-09-01 Epub Date: 2025-08-20 DOI: 10.1016/j.inpm.2025.100632
Asher Smuek , Rishi Bakshi , Romeo Mays , Lisa Huynh , Joshua Levin , Joshua Rittenberg , Matthew Smuck

Background

“Is this injection going to hurt?” Physicians typically answer this from experience since accurate answers are not available in the literature.

Objective

To quantify pain during common lumbosacral spine injections and compare to baseline pain prior to the injections. Analyze differences based on demographic and procedure variables.

Methods

This is a secondary analysis of prospectively collected data from a multicenter trial of patients undergoing bilateral symmetric transforaminal epidural (TFE), facet joint (FJ), or sacroiliac joint (SIJ) injections. Numeric pain ratings (0-10) were obtained at baseline in preop (“What is your current pain?”) and for each injection procedure (“How much did this injection hurt from start to finish?”) first on the right side then the left. Between group comparisons used Chi-squared and ANOVA for categorical and continuous variables, respectively. T-tests compared various pain responses, and multivariate regression determined factors associated with higher procedure pain.

Results

From 244 injections (124 TFE, 60 FJ, 60 SIJ) on 122 consecutive patients (mean age 57.2, 50 % female), age and BMI did not differ between injection groups while sex did (p = 0.001) with more FJ males and SIJ females. Mean baseline pain was statistically equivalent between demographic and injection groups. Mean procedure pain was consistently higher than mean baseline pain, however this difference was small and non-significant for TFE (4.0 vs 3.8) and FJ (3.9 vs 3.3), but larger and significant for SIJ (5.3 vs. 3.6; p = 0.0001). In the multivariate regression analysis only 2 variables remained associated with higher procedure pain, older age (p < 0.0001) and SIJ injection group (p = 0.0021).

Conclusion

The majority of patients (79.1 %) report mild or moderate pain during common lumbosacral spine injections. The average procedure pain of 4.3 on the NPRS scale was only 0.7 points higher than baseline pain recorded in pre-op. Procedure pain from TFE and FJ injections is statistically equivalent to baseline pain and to each other, while SIJ injections produce higher procedure pain with a significant +1.7 point mean increase in pain from baseline. Finally, older adults report significantly greater procedure pain compared to those under 65 years old.
“打针会痛吗?”医生通常根据经验回答这个问题,因为在文献中没有准确的答案。目的量化普通腰骶椎注射时的疼痛,并与注射前的基线疼痛进行比较。根据人口统计和程序变量分析差异。方法:这是一项前瞻性多中心试验收集的数据的二次分析,这些患者接受双侧对称经椎间孔硬膜外(TFE)、小关节(FJ)或骶髂关节(SIJ)注射。在术前基线时获得数值疼痛评分(0-10)(“你目前的疼痛是什么?”)以及每个注射过程(“从开始到结束,注射有多痛?”)先在右边,然后在左边。组间比较分别对分类变量和连续变量使用卡方和方差分析。t检验比较了各种疼痛反应,多变量回归确定了与较高手术疼痛相关的因素。结果连续122例患者(平均年龄57.2岁,女性占50%)接受244次注射(TFE 124次,FJ 60次,SIJ 60次),注射组间年龄和BMI无差异,性别有差异(p = 0.001), FJ男性多于SIJ女性。人口统计学组和注射组的平均基线疼痛在统计学上是相等的。平均手术疼痛始终高于平均基线疼痛,然而TFE (4.0 vs 3.8)和FJ (3.9 vs 3.3)的差异很小且不显著,但SIJ的差异更大且显著(5.3 vs 3.6; p = 0.0001)。在多变量回归分析中,只有2个变量与较高的手术疼痛、年龄(p < 0.0001)和SIJ注射组(p = 0.0021)相关。结论:大多数患者(79.1%)报告腰骶椎注射时出现轻度或中度疼痛。NPRS量表的平均手术疼痛为4.3分,仅比术前记录的基线疼痛高0.7分。TFE和FJ注射的手术疼痛在统计学上与基线疼痛相当,并且彼此相等,而SIJ注射产生更高的手术疼痛,疼痛比基线平均增加1.7点。最后,与65岁以下的人相比,老年人报告的手术疼痛明显更大。
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引用次数: 0
Dorsal root ganglion stimulation for multifactorial refractory foot pain: A case report 背根神经节刺激治疗多因素难治性足痛1例
Pub Date : 2025-09-01 Epub Date: 2025-07-16 DOI: 10.1016/j.inpm.2025.100614
Hasan Sen, Amanda Cooper, Aaron Conger, Zachary L. McCormick, Allison Glinka Przybysz

Background

Dorsal root ganglion (DRG) stimulation has emerged as an effective, targeted neuromodulation therapy for refractory pain of the lower extremities, particularly in the setting of complex regional pain syndrome. However, preliminary evidence supporting DRG for other applications, such as peripheral neuropathy or refractory nociceptive pain, is currently limited to patient populations with discrete pain sources. We report a case of chronic, multifactorial foot pain successfully treated with a right S1 DRG stimulation after failure of multiple prior interventions including physical therapy, corticosteroid injections, and surgeries.

Case report

A 74-year-old male presented with chronic refractory right foot pain, diagnosed with L5-S1 radiculopathy, peripheral neuropathy, persistent post-surgical pain following multiple procedures, including partial toe pain, which significantly impaired his mobility and quality of life. DRG stimulation was pursued after multiple prior interventions, including physical therapy, corticosteroid injections, surgeries, and a trial of peripheral nerve stimulation (PNS) that provided only temporary relief. Following a successful stimulation trial, a permanent DRG device was implanted at the S1 level, resulting in meaningful, sustained pain relief and functional improvement.

Conclusion

DRG stimulation represents a promising treatment for refractory lower extremity pain, especially in cases where traditional therapies have failed. This case illustrates its therapeutic potential in patients with complex refractory neuropathic pain of mixed etiologies.
背景:刺激背根神经节(DRG)已成为下肢难治性疼痛的一种有效的靶向神经调节疗法,特别是在复杂区域性疼痛综合征的情况下。然而,支持DRG用于其他应用的初步证据,如周围神经病变或难治性伤害性疼痛,目前仅限于离散疼痛源的患者群体。我们报告了一例慢性多因素足部疼痛,在多次干预失败后,通过右S1 DRG刺激成功治疗,包括物理治疗、皮质类固醇注射和手术。病例报告一名74岁男性,慢性难治性右脚疼痛,诊断为L5-S1神经根病,周围神经病变,多次手术后持续的术后疼痛,包括部分脚趾疼痛,严重损害了他的活动能力和生活质量。DRG刺激是在多次干预后进行的,包括物理治疗、皮质类固醇注射、手术和外周神经刺激(PNS)试验,该试验仅提供暂时缓解。在成功的刺激试验后,在S1水平植入永久性DRG装置,导致有意义的、持续的疼痛缓解和功能改善。结论drg刺激治疗难治性下肢疼痛是一种很有前景的治疗方法,特别是在传统治疗方法失败的情况下。这个病例说明了它在复杂难治性神经性疼痛患者的治疗潜力。
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引用次数: 0
Safety profile of cervical transforaminal epidural steroid injections performed while maintaining anticoagulation, aspirin, or NSAIDs 在维持抗凝、阿司匹林或非甾体抗炎药的同时进行经椎间孔硬膜外类固醇注射的安全性分析
Pub Date : 2025-09-01 Epub Date: 2025-07-24 DOI: 10.1016/j.inpm.2025.100618
David Levi , Dustin Randall , Scott Horn , Austin Russo , Josh Gabri , Morgan Durand , Joshua Levin

Summary of background data

The risk of a symptomatic epidural bleed in patients continuing anticoagulation during most types of spinal injection procedures is extremely low. Cervical epidural steroid injections involve a unique risk of a catastrophic complication if an epidural hematoma is to occur secondary to spinal cord compression due to the anatomic confines of the cervical spinal canal. There is minimal research on the risk of cervical transforaminal epidural steroid injections (CTFESI) with anticoagulation.

Objective

Evaluate the risk of performing CTFESI with patients continuing prescribed anticoagulation medication.

Methods

A retrospective review was performed at two practice settings, a community-based outpatient practice and an academic practice, to identify all CTFESI performed between June 2018 through November 2023. Patient medical records were reviewed for the presence of anticoagulation and NSAID medication the day of the CTFESI. Data analysis used descriptive statistics to summarize the distribution of anticoagulants, NSAIDs, and cervical levels across practices, along with medication frequencies and percentages.

Results

A total of 2792 CTFESIs were performed across both settings between June 2018 and November 2023. Of those, 1040 CTFESIs (37.2 %) were performed on patients taking some form of anticoagulant medication. 277 CTFESI were performed on patients taking anticoagulants or aspirin or a combination of anticoagulants and ASA. 763 were performed on patients taking NSAIDs. There were no reported cases of symptomatic epidural hematomas or other bleeding complications in the immediate post-procedural period or up to 1 week following the procedure.

Conclusion

It is likely that CTFESI can be safely performed in patients continuing anticoagulation, aspirin (ASA), or NSAIDs. Discontinuing anticoagulants or NSAIDs for CTFESIs may not be necessary. Further studies are warranted to confirm these results.
背景资料总结:在大多数类型的脊髓注射过程中,持续抗凝的患者出现症状性硬膜外出血的风险极低。由于颈椎管的解剖限制,如果发生继发于脊髓压迫的硬膜外血肿,则宫颈硬膜外类固醇注射具有独特的灾难性并发症风险。很少有关于经椎间孔硬膜外类固醇注射(CTFESI)与抗凝的风险的研究。目的评价继续服用抗凝药物的患者行CTFESI的风险。方法回顾性分析了两个实践环境,一个社区门诊实践和一个学术实践,以确定2018年6月至2023年11月期间进行的所有CTFESI。检查患者在CTFESI当天是否有抗凝血和非甾体抗炎药。数据分析使用描述性统计来总结抗凝血剂、非甾体抗炎药和宫颈水平在不同实践中的分布,以及用药频率和百分比。结果在2018年6月至2023年11月期间,两种情况下共进行了2792次ctfis。其中,1040例CTFESIs(37.2%)是对服用某种形式抗凝药物的患者进行的。277例使用抗凝药物或阿司匹林或抗凝药物与ASA联合使用的患者进行CTFESI。763例患者服用非甾体抗炎药。在手术后立即或手术后1周内没有出现症状性硬膜外血肿或其他出血并发症的报告。结论CTFESI在持续使用抗凝、阿司匹林(ASA)或非甾体抗炎药的患者中可能是安全的。ctfis患者可能没有必要停用抗凝血剂或非甾体抗炎药。需要进一步的研究来证实这些结果。
{"title":"Safety profile of cervical transforaminal epidural steroid injections performed while maintaining anticoagulation, aspirin, or NSAIDs","authors":"David Levi ,&nbsp;Dustin Randall ,&nbsp;Scott Horn ,&nbsp;Austin Russo ,&nbsp;Josh Gabri ,&nbsp;Morgan Durand ,&nbsp;Joshua Levin","doi":"10.1016/j.inpm.2025.100618","DOIUrl":"10.1016/j.inpm.2025.100618","url":null,"abstract":"<div><h3>Summary of background data</h3><div>The risk of a symptomatic epidural bleed in patients continuing anticoagulation during most types of spinal injection procedures is extremely low. Cervical epidural steroid injections involve a unique risk of a catastrophic complication if an epidural hematoma is to occur secondary to spinal cord compression due to the anatomic confines of the cervical spinal canal. There is minimal research on the risk of cervical transforaminal epidural steroid injections (CTFESI) with anticoagulation.</div></div><div><h3>Objective</h3><div>Evaluate the risk of performing CTFESI with patients continuing prescribed anticoagulation medication.</div></div><div><h3>Methods</h3><div>A retrospective review was performed at two practice settings, a community-based outpatient practice and an academic practice, to identify all CTFESI performed between June 2018 through November 2023. Patient medical records were reviewed for the presence of anticoagulation and NSAID medication the day of the CTFESI. Data analysis used descriptive statistics to summarize the distribution of anticoagulants, NSAIDs, and cervical levels across practices, along with medication frequencies and percentages.</div></div><div><h3>Results</h3><div>A total of 2792 CTFESIs were performed across both settings between June 2018 and November 2023. Of those, 1040 CTFESIs (37.2 %) were performed on patients taking some form of anticoagulant medication. 277 CTFESI were performed on patients taking anticoagulants or aspirin or a combination of anticoagulants and ASA. 763 were performed on patients taking NSAIDs. There were no reported cases of symptomatic epidural hematomas or other bleeding complications in the immediate post-procedural period or up to 1 week following the procedure.</div></div><div><h3>Conclusion</h3><div>It is likely that CTFESI can be safely performed in patients continuing anticoagulation, aspirin (ASA), or NSAIDs. Discontinuing anticoagulants or NSAIDs for CTFESIs may not be necessary. Further studies are warranted to confirm these results.</div></div>","PeriodicalId":100727,"journal":{"name":"Interventional Pain Medicine","volume":"4 3","pages":"Article 100618"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Interventional Pain Medicine
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