Journal of Holistic Integrative Pharmacy最新文献

{"title":"An assessment of antidepressant like potentiality of Phyllanthus emblica on experimental rodent model of depressive disorder under the light of numerous behavioural test batteries","authors":"Md. Rafat Tahsin ,&nbsp;Arifa Sultana ,&nbsp;Fahima Aktar ,&nbsp;Nasiba Binte Bahar ,&nbsp;Md Naeem Hossain Rony ,&nbsp;Rifah Noor Chowdhury ,&nbsp;Sabiha Rahman Mim ,&nbsp;Safa H. Qahl ,&nbsp;Ishrat Jahan ,&nbsp;Md. Shah Amran","doi":"10.1016/j.jhip.2025.09.006","DOIUrl":"10.1016/j.jhip.2025.09.006","url":null,"abstract":"<div><h3>Objective</h3><div>The unfavorable costs and effects of currently accessible antidepressant agents necessitate the development of more potent and safe alternatives, that will obviate the potential problems associated with the commercially available marketed ones. <em>Phyllanthus emblica</em>, widely known as emblic or amla, is utilized in traditional Asian medicine. In this study, the potential of <em>Phyllanthus emblica</em>'s extract as an antidepressant drug was investigated.</div></div><div><h3>Methods</h3><div>The dried and pulverized powder of fruit was extracted in 70% ethanol. Rat model was used to assess the antidepressant effect of this extract and rats were treated with 800 ​mg/kg extract for 28 days. To assess the impact of the treatment, different behavioural tests like forced swimming test, tail suspension test, open field test, elevated plus maze, light dark box test, and coat state test were conducted.</div></div><div><h3>Results</h3><div>Following the administration of <em>Phyllanthus emblica</em>'s extract, a significant decrease in immobility times was observed in the forced swimming test and tail suspension test (<em>P</em> ​&lt; ​0.05). Similarly, the intake of glucose water was increased significantly (<em>P</em> ​&lt; ​0.05) after <em>Phyllanthus emblica</em>'s extract treatment. Additionally, in all behavioural tests associated with the open field test, elevated plus maze, and light dark box test, abnormal behavioural states were significantly restored (<em>P</em> ​&lt; ​0.05) in the extract-treated group. Besides, in all behavioural tests, it has been observed that the standard drug also restored all the abnormal behavioural conditions. In silico docking revealed that compounds C_66 (stigmast-4-en-3-one) and C_43 (7-ketositosterol) exhibited the strongest binding affinity for MAO-A (−11.8 and −11.7 ​kJ/mol), surpassing the control drug Phenelzine (−6.7 ​kJ/mol), with distinct binding site residues. For hSERT, C_71 (Phyllanemblinin A, −11.4 ​kJ/mol) and C_66 (−10.8 ​kJ/mol) outperformed Fluoxetine (−8.9 ​kJ/mol), with Stigmast-4-en-3-one showing potential multi-target activity. ADME and toxicity prediction indicated low GI absorption for all candidates; C_43 showed the best drug-likeness and was predicted as non-toxic (class 6), while C_66 and C_71 were class 5, with additional nephrotoxicity and mutagenicity for C_71.</div></div><div><h3>Conclusion</h3><div>It can be inferred that the fruit extract of <em>Phyllanthus emblica</em> can efficiently reverse the disturbing psychological ailment towards a healthy status, which has the potential to be further developed into an alternative of currently accessible marketed antidepressant agents.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 343-361"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of fresh Dendrobium officinale against gastric ulcer by regulating Keap1-Nrf2 signaling pathway","authors":"Shuidi Zhang ,&nbsp;Bei Gui ,&nbsp;Zijun Wu ,&nbsp;Yuanjun Wei ,&nbsp;Hong Deng ,&nbsp;Kunping Li ,&nbsp;Caie Guo ,&nbsp;Yanfen Chen","doi":"10.1016/j.jhip.2025.09.007","DOIUrl":"10.1016/j.jhip.2025.09.007","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to systematically investigate the gastroprotective effects and underlying mechanisms of fresh <em>Dendrobium officinale</em> granules (FDG), a clinically convenient formulation of fresh <em>Dendrobium officinale</em> (<em>D. officinale</em>).</div></div><div><h3>Methods</h3><div>For the convenience of clinical use, fresh <em>D. officinale</em> was prepared into granules. The active ingredients of FDG were detected by HPLC. The gastroprotective efficacy of FDG was investigated in mice with alcoholic, indometacin, and reserpine gastric ulcer models, and in rats with acetic acid chronic gastric ulcers. The ulcer index, histopathology of gastric mucosa, and the levels of nitric oxide (NO), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) were measured. Network pharmacology method was used to predict the potential mechanism of FDG. Lastly, the expression levels of Keap1, Nrf2, and HO-1 were assessed by qRT-PCR and Western blot methods.</div></div><div><h3>Results</h3><div>HPLC result showed that the four active ingredients of FDG were vicenin-2, isoschaftoside, schaftoside, and 6-C-xylosyl-8-C-glucosylapigenin. FDG exerted significant effects against acute and chronic gastric ulcers in a dose-dependent manner. The network pharmacology analysis predicted the potential mechanism on oxidative stress and its related pathways. FDG remarkably increased SOD, NO, and CAT levels and lowered MDA levels in various gastric ulcer models, indicating it could enhance the antioxidant capacity to prevent gastric ulcers. FDG obviously down-regulated Keap1 expression and up-regulated Nrf2 and HO-1 expression.</div></div><div><h3>Conclusion</h3><div>This study proved the gastroprotective efficacy ​of fresh <em>D. officinale</em>, and its mechanism may be related to the antioxidation activity and the regulation of Keap1-Nrf2 signaling pathway.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 362-372"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Holistic insights of 6D printing in healthcare","authors":"Jatin Tekawade,&nbsp;Rohan Barse,&nbsp;Vijay Jagtap","doi":"10.1016/j.jhip.2025.09.003","DOIUrl":"10.1016/j.jhip.2025.09.003","url":null,"abstract":"<div><div>Additive manufacturing has recently demonstrated significant progress in healthcare. Six-dimensional (6D) printing is an emerging field that holds great promise through the rapid, layer-by-layer creation of complex objects capable of changing over time in response to external stimuli, resulting in dynamic and adaptable products. 6D printing represents a superimposition of 4D and 5D printing, combining the stimuli-responsiveness of 4D printing with the structural robustness of 5D printing. It uniquely enables autonomous, adaptive drug delivery systems by utilizing smart materials such as shape-memory alloys, responsive polymers, and hydrogels that react to environmental triggers. This review explores the evolution, mechanisms, significance, and innovations of 6D printing, which has made notable strides toward patient-centered medical approaches. Future developments in 6D printing may involve the use of material panels that adapt to stimuli varying over time under physiological conditions, offering new possibilities for advanced medical applications and solutions.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 263-275"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on clinical diagnosis, pathogenesis and therapeutic strategies of drug-induced liver injury","authors":"Xinxin Tan ,&nbsp;Jiajia Gao ,&nbsp;Chao Wang","doi":"10.1016/j.jhip.2025.09.002","DOIUrl":"10.1016/j.jhip.2025.09.002","url":null,"abstract":"<div><div>Drug-induced liver injury (DILI) is a severe adverse reaction caused by various drugs and their metabolites, with complex clinical manifestations, and severe cases may progress to acute liver failure (ALF) or even death. Currently, the pathogenesis of DILI has not been fully elucidated, and specific diagnostic indicators and effective therapeutic strategies are lacking, so it is crucial to deeply analyze its pathogenesis and develop precise intervention strategies. This review explores key pathogenic mechanisms in the development of DILI, with a focus on mitochondrial dysfunction, ferroptosis, immune responses and the gut-liver axis. It further systematically summarizes the clinical diagnostic approaches for DILI, including common diagnostic methods and potential biomarkers. Additionally, the review discusses therapeutic strategies for DILI, encompassing western medical treatments, ethnomedical treatments and non-pharmacological treatments. Although N-acetylcysteine (NAC) remains the FDA-approved standard treatment for acetaminophen (APAP) overdose, superior therapeutic options for DILI need to be explored urgently due to its therapeutic limitations and side effects. In the future, the prevention and treatment strategy of DILI will rely on deeper mechanistic investigations, development of novel biomarkers, and further exploration of multi-targeted traditional Chinese medicine (TCM) therapies.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 308-321"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential small-molecule compounds and targets for Alzheimer's disease: Integrating bioinformatics analysis and in vitro verification","authors":"Jiaorong Zheng ,&nbsp;Deti Peng ,&nbsp;Zhigao Liao ,&nbsp;Min Hong ,&nbsp;Weiqu Yuan ,&nbsp;Danping Huang","doi":"10.1016/j.jhip.2025.09.005","DOIUrl":"10.1016/j.jhip.2025.09.005","url":null,"abstract":"<div><h3>Objective</h3><div>Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by progressive memory decline and cognitive dysfunction. The specific pathogenesis of AD remains unclear. This study aimed to explore the crucial genes and therapeutic small-molecule compounds in AD via integrated bioinformatics analysis, molecular docking, and <em>in vitro</em> verification.</div></div><div><h3>Methods</h3><div>The gene dataset GSE122063, including 12 samples from patients with AD and 11 non-demented control samples, was downloaded from the Gene Expression Omnibus (GEO) database. The online tool GEO2R was used to analyze differentially expressed genes (DEGs). Functional enrichment analysis of the DEGs was performed using DAVID and ClueGo databases. A protein-protein interaction network was constructed using the STRING database and visualized in Cytoscape. Potential small-molecule compounds for AD therapy were screened using the Connectivity map database. The crucial genes in a rat model of AD were confirmed by RT-PCR. Molecular docking of the screened crucial genes and small-molecule compounds was further performed to identify potential therapeutic drugs for AD.</div></div><div><h3>Results</h3><div>A total of 1145 DEGs were identified, which were enriched in intracellular protein transport, cell cycle, establishment of protein localization to membrane, and so on. Eight hub genes, including <em>RPS29</em>, <em>CREBBP</em>, <em>ANAPC10</em>, <em>ANAPC4</em>, <em>MAGOHB</em>, <em>TCEB2</em>, <em>RPL10A</em>, and <em>SEC61A1</em>, were identified in the protein-protein interaction network. The MAPK signaling pathway was closely related to AD. Furthermore, increased expression of <em>CREBBP</em> was confirmed in the rat model of AD, and molecular docking revealed that CREBBP exhibited the strongest binding affinity with prochlorperazine.</div></div><div><h3>Conclusion</h3><div><em>CREBBP</em> was identified as a crucial hub gene and might serve as a potential target for AD. Prochlorperazine, which exhibited strong binding to CREBBP, showed potential as a therapeutic drug in AD.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 324-332"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ToC","authors":"","doi":"10.1016/S2707-3688(25)00048-2","DOIUrl":"10.1016/S2707-3688(25)00048-2","url":null,"abstract":"","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages i-ii"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145361865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical profiles, biological activities and medicinal importance of Aloe vera L.: A review","authors":"Suchhanda Nandi,&nbsp;Golak Majumdar,&nbsp;Shyamapada Mandal","doi":"10.1016/j.jhip.2025.07.001","DOIUrl":"10.1016/j.jhip.2025.07.001","url":null,"abstract":"<div><div><em>Aloe vera</em> (Av) is revered in Ayurveda as the \"wand of heaven\" or \"heaven's blessing\" and precisely the \"silent healer\". This herbaceous plant belongs to Asphodelaceae family, previously classified as Liliaceae. In Traditional Chinese Medicine (TCM), Av is acknowledged for its abundant bioactive substances that have considerable therapeutic value. Therefore, the objective of this review is to analyze Av's bioactive compounds, highlighting its medicinal potential in drug development. An extensive literature review is performed utilizing databases such as PubMed, Web of Science, SpringerLink, and more until October 2024. The research investigates the bioactive compounds of Av and their <em>in vivo</em>, <em>in vitro</em>, and <em>in silico</em> effects on infections (bacterial, fungal, viral, and protozoan infections), along with their medicinal properties and significance in drug development. The most investigated active constituents of Av are aloin, emodin, acemannan, and aloesin. Av contains more than 100 potentially active components from six different classes: anthraquinone, chromone, phenylpropanoids, coumarins, phenylpyrone, and phytosterols, focusing on its anti-infective, anti-cancer, anti-diabetic, anti-oxidant, anti-inflammatory, immuno-modulatory activity and impact on neural diseases as well, based on peer-reviewed scientific data. By deepening the understanding of Av's medicinal value, this study may provide a reference for its future research and the development of new bioactive drug molecules from Av.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 251-262"},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144771652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effects of raw rhubarb on gastrointestinal complications in ischemic stroke: An integrated analysis of gut microbiota, metabolomics, and network pharmacology","authors":"Zhanhao Ye ,&nbsp;Dongmin Cao ,&nbsp;Wenxing Ao ,&nbsp;Ting Li ,&nbsp;Minghua Xian ,&nbsp;Shumei Wang","doi":"10.1016/j.jhip.2025.05.002","DOIUrl":"10.1016/j.jhip.2025.05.002","url":null,"abstract":"<div><h3>Objective</h3><div>Gastrointestinal complications (GITC) are a major cause of increased morbidity and mortality in stroke patients, significantly impairing recovery by triggering systemic inflammation and hindering brain healing. Raw Rhubarb (RR) is a commonly used traditional Chinese medicine with significant potential in treating GITC of ischemic stroke (IS). However, its therapeutic mechanisms remain largely unknown. This study aims to investigate the therapeutic effects and potential mechanisms of RR on GITC in IS through an integrated analysis of gut microbiota, metabolomics, and network pharmacology.</div></div><div><h3>Methods</h3><div>Male Sprague-Dawley rats were subjected to middle cerebral artery occlusion/reperfusion (MCAO/R) to induce IS. The rats were divided into six groups: sham, model, nimodipine-treated, and three different dose groups for RR. Neuroprotective efficacy was assessed using infarct size measurement, neurological scoring, and histopathological analysis. Gut microbiota composition was analyzed through 16S rRNA gene sequencing, while metabolomic profiling of brain and colon tissues was performed using UPLC-Q-Orbitrap HRMS/MS. Multivariate statistical methods were employed to identify the key metabolites and pathways affected by RR treatment. Correlation analysis was conducted to establish links between gut microbiota alterations and differential metabolites. Additionally, network pharmacology, molecular docking analysis, and Western blot assays were utilized to explore the molecular mechanisms underlying RR's treatment of GITC in IS.</div></div><div><h3>Results</h3><div>RR showed significant neuroprotective effects, reducing infarct volume, improving neurological scores, and restoring intestinal function compared to the model group. In addition, gut microbiota analysis revealed that RR administration reversed gut microbiota dysbiosis in MCAO/R rats by increasing the abundance of <em>Bifidobacterium</em> and <em>Lactobacillus</em> while decreasing the abundance of <em>Escherichia-Shigella</em>. Metabolomics analysis indicated that RR reversed the metabolic disturbances in MCAO/R rats by modulating arachidonic acid (AA) metabolism. Correlation analysis showed that AA and its metabolites, such as PGE2, were closely associated with <em>Bifidobacterium</em> and <em>Lactobacillus</em>. Combining metabolomics, network pharmacology, and molecular docking analysis suggested that RR might regulate AA metabolism through the PI3K/mTOR signaling pathway to treat GITC in IS. Finally, Western blot validation confirmed that RR modulates the PI3K/mTOR signaling pathway.</div></div><div><h3>Conclusion</h3><div>These findings indicate that RR holds significant promise as a therapeutic strategy for addressing GITC of IS. The protective effects mediated by RR are associated with the improvement of gut microbiota dysbiosis and metabolic disturbances.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 2","pages":"Pages 136-149"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review of five selected underutilized medicinal plants of Sri Lanka: Focusing on ethnobotany, phytochemistry and bioactivities, and evaluation of their potential for novel herbal product development","authors":"Isuru Sakbo Uyangoda ,&nbsp;Mayuri Munasinghe","doi":"10.1016/j.jhip.2025.06.005","DOIUrl":"10.1016/j.jhip.2025.06.005","url":null,"abstract":"<div><div><em>Ageratum conyzoides</em> L., <em>Artocarpus gomezianus</em> Wall. ex Trécul, <em>Euphorbia hirta</em> L., <em>Plectranthus zeylanicus</em> Benth., and <em>Piper sarmentosum</em> Roxb. have long been utilized in traditional medical practices, particularly across South and Southeast Asia. Despite their significant ethnopharmacological potential to treat various disorders, these plants remain underutilized in Sri Lanka. This review aims to evaluate the habit, propagation, ethnomedicinal uses, phytochemistry, and pharmacological properties of these five underutilized medicinal plants to promote their sustainable utilization in the herbal products industry of Sri Lanka. The plants were selected based on data from pharmacopeias and interviews with traditional medical practitioners. Scientific information on their ethnomedicinal uses, phytochemical compositions, and pharmacological properties was gathered from key scientific databases, including PubMed, Scopus, ScienceDirect, and Google Scholar, as well as web references and books. This information was analyzed to assess the factors contributing to their underutilization and their potential for novel herbal product development in Sri Lanka. All five plants possess a wide range of ethnomedicinal uses and are rich in bioactive compounds, including alkaloids, terpenoids, stilbenoids, and polyphenolic compounds. These bioactive compounds have been scientifically validated for their pharmacological properties, making these plants strong candidates for the development of novel pharmaceuticals and cosmeceuticals. However, their full potential remains largely untapped, primarily due to the lack of detailed phytochemical characterization and bioactive studies specific to Sri Lanka. Further preclinical and clinical research is needed to evaluate their therapeutic outcomes within the local context. The findings of this scoping review will guide future research and encourage broader use of these underutilized plants. Promoting their use will provide a sustainable alternative to the overexploitation of commonly used medicinal plants and support effective biodiversity conservation and resource management.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 2","pages":"Pages 209-223"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial function maintenance and mitochondrial training in ageing and related diseases","authors":"Gan Gao ,&nbsp;Zhihui Xie ,&nbsp;Hongliang Huang","doi":"10.1016/j.jhip.2025.04.001","DOIUrl":"10.1016/j.jhip.2025.04.001","url":null,"abstract":"<div><div>Cellular senescence driven by mitochondrial dysfunction is a key contributor to ageing and related diseases. The decline in the quality and quantity of healthy mitochondria with ageing disrupts energy production, redox homeostasis, and intracellular signaling. Mitochondrial quality control (MQC) is a cellular self-repair mechanism that protects mitochondrial function and maintains a healthy mitochondrial network. Targeted regulation of MQC is expected to moderate the development of cellular senescence and related diseases. We explored the impact of mitochondrial function on cell fate at the molecular and organelle levels, analyzed the role of mitochondria-targeted interventions for delaying cellular senescence and ameliorating age-related diseases, and pointed out the idea of increasing the critical level of healthy mitochondria to cope with internal and external stressful stimuli and to improve the ability of self-repairing by exercising and protecting mitochondria in the long term.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 2","pages":"Pages 159-174"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}