Condensation of ethyl hydantoate with substituted biguanides gave triazinylmethyl-ureas (I) which are pharmacologically active.
Condensation of ethyl hydantoate with substituted biguanides gave triazinylmethyl-ureas (I) which are pharmacologically active.
Pretreatment of rats and mice with meprobamate prior to inoculation with lethal doses of bacterial exotoxins and endotoxins resulted in a highly significant prolongation of life. However, the drug showed no effect on survival time in overwhelming infections induced by Diplococcus pneumoniae or Salmonella typhimurium. In Salmonella enteritidis infection, chlorpromazine increased the susceptibility of mice far more markedly than did meprobamate.
Eucalyptol is determined by treating samples with an excess of hydrogen bromide reagent. After a forty-eight-hour standing period, excess hydrogen bromide is titrated with sodium acetate in acetic acid. Mixtures of eucalyptol with thymol, menthol, and camphor are analyzed for eucalyptol content. Quantitative recoveries are reported.
The root of Machilus macrantha Nees has been studied for physical characteristics, histology, extractives, ash, and alkaloidal constituents. Anatomical characteristics include: a continuous band of small stone cells constituting phelloderm; a pericycle consisting of large stone cells; isolated groups of stone cells in the phloem; lignified phloem and xylem fibers with narrow and large lumen, respectively; copious mucilaginous matter in the phloem parenchyma cell walls; and oil cells in cortex, phloem, and xylem. The extractives showed the presence of phytosterols, glycosides, and volatile oil. From the limed drug, extraction and isolation of a base as hydrochloride, provisionally named “machiline hydrochloride,” melting with decomposition between 248–250°, two alkaloids as picrates and one reineckate are described. The yield of machiline hydrochloride was highest (0.0725 per cent) from the root collected in the month of May. Paper chromatography of the extract revealed the presence of at least five alkaloids.
Exposure of Penicillium notatum to ionized air reduces the production of penicillin, negative ions exerting a greater effect than positive ions. Growth of the mycelium and germination of spores also are depressed, but positive ions exert a greater effect than negative ions on spore germination. Production of carbon dioxide is depressed to about the same extent as mycelial growth.
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：