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Journal of the American Pharmaceutical Association (Scientific ed.)最新文献

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Canine Blood Sugar and Lactic Acid Responses to Adrenergic Amines after Ganglion Block* 神经节阻滞后犬血糖和乳酸对肾上腺素能胺的反应*
Journal of the American Pharmaceutical Association (Scientific ed.)
Pub Date : 1960-11-01 DOI: 10.1002/jps.3030491108
R.S. McCutcheon

Since preliminary studies indicated that a ganglionic block before infusions of some adrenergic amines resulted in an increased production of blood lactic acid and blood sugar, it was postulated that this might be due to an interruption of Cori's cycle. This experiment shows that there is a significant increase in lactic acid produced by two of the drugs after blocking and an indication that two others also have this effect. The results on blood sugar were not significant. Evidence is presented here that the conversion of lactic acid to glycogen in the liver is blocked or inhibited by use of the ganglion blocking agent, mecamylamine, accounting for an accumulation of blood lactic acid under the conditions of the experiment.

由于初步研究表明，在输注一些肾上腺素能胺之前神经节阻滞导致血乳酸和血糖的产生增加，因此假设这可能是由于Cori周期的中断。本实验表明，阻断后两种药物产生的乳酸显著增加，表明另外两种药物也有这种作用。对血糖的影响不显著。这里提出的证据表明，使用神经节阻滞剂甲胺，可以阻断或抑制肝脏中乳酸向糖原的转化，这是实验条件下血乳酸积累的原因。
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引用次数: 1
Note on the Hydrophile-Lipophile Balance of Tragacanth* 黄芪的亲水-亲脂平衡注释*
Journal of the American Pharmaceutical Association (Scientific ed.)
Pub Date : 1960-11-01 DOI: 10.1002/jps.3030491115
Wallace L. Guess
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引用次数: 1
Medicinal chemistry. 2nd ed. Edited by Alfred Burger. Interscience Publishers, Inc., 250 Fifth Ave., New York 1, N. Y., 1960. xiii + 1243 pp. 17.5 × 25 cm. Price $37.50 药物化学。第 2 版，阿尔弗雷德-伯格编辑。Interscience Publishers, Inc., 250 Fifth Ave., New York 1, N. Y., 1960. xiii + 1243 pp.17.5 × 25 厘米。售价 37.50 美元
Journal of the American Pharmaceutical Association (Scientific ed.)
Pub Date : 1960-11-01 DOI: 10.1002/jps.3030491127
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引用次数: 0
Oxidation-reduction potentials of organic systems. By W. Mansfield Clark. The Williams & Wilkins Co., 428 East Preston St., Baltimore 2, Md., 1960. xi + 584 pp. 15 × 23 cm. Price $13.50 有机系统的氧化还原电位。曼斯菲尔德·克拉克著。威廉姆斯和威尔金斯公司，马里兰州巴尔的摩市东普雷斯顿街428号，1960年。价格13.50美元
Journal of the American Pharmaceutical Association (Scientific ed.)
Pub Date : 1960-11-01 DOI: 10.1002/jps.3030491129
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引用次数: 0
Determination of Hydrochlorothiazide in Urine* 尿中氢氯噻嗪的测定*
Journal of the American Pharmaceutical Association (Scientific ed.)
Pub Date : 1960-11-01 DOI: 10.1002/jps.3030491110
Herbert Sheppard, Thomas F. Mowles, Albert J. Plummer

Hydrochlorothiazide may be determined in urine by extracting with ethyl acetate and either reacting directly with chromotropic acid or hydrolyzing first with alkali followed by diazotization and condensation with N-(1-naphthyl)-ethylene diamine hydrochloride.

尿中氢氯噻嗪的测定可采用乙酸乙酯提取，直接与变色酸反应或先与碱水解，再与N-(1-萘基)-乙二胺缩合。
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引用次数: 20
Biochemistry of plants and animals. By M. Frank Mallette, Paul M. Althouse, and Carl O. Clagett. John Wiley & Sons, Inc., 440 Fourth Ave., New York 16, N. Y., 1960. xiii + 552 pp. 15 × 23 cm. Price $8.50 动植物生物化学》。作者：M. Frank Mallette、Paul M. Althouse 和 Carl O. Clagett。John Wiley & Sons, Inc., 440 Fourth Ave., New York 16, N. Y., 1960. xiii + 552 pp.15 × 23 厘米。售价 8.50 美元
Journal of the American Pharmaceutical Association (Scientific ed.)
Pub Date : 1960-11-01 DOI: 10.1002/jps.3030491135
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引用次数: 0
Précis de chimie biologique. Vol. 2. By J. E. Courtois and R. Perlè. Masson et Cie., 120, Boulevard Saint-Germain, Paris 6e, France, 1960. viii + 620 pp. 16 × 21 cm. Price 46 NF Précis de chimie biologique.第 2 卷。作者：J. E. Courtois 和 R.Perlè.Viii + 620 页，16 × 21 厘米。价格 46 NF
Journal of the American Pharmaceutical Association (Scientific ed.)
Pub Date : 1960-11-01 DOI: 10.1002/jps.3030491132
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引用次数: 0
Antimicrobial Activity, In Vitro, of Chlorhexidine* 氯己定的体外抗菌活性*
Journal of the American Pharmaceutical Association (Scientific ed.)
Pub Date : 1960-11-01 DOI: 10.1002/jps.3030491113
C.A. Lawrence

Comparative in vitro tests indicate that chlorhexidine has greater antibacterial activity than benzalkonium chloride, a combination of o-phenyl- and p-tert-amyl-phenol, and an iodine-polyvinylpyrrolidone complex under the test conditions. Chlorhexidine in relatively high dilutions was effective against several cultures of Gram-negative bacteria in the phenol coefficient test. In moderate concentrations, it was active against staphylococci and anaerobes.

体外对比实验表明，在实验条件下，氯己定的抑菌活性高于苯扎氯铵、邻苯基和对叔戊基酚的组合物以及碘-聚乙烯吡咯烷酮配合物。在苯酚系数试验中，较高稀释度的氯己定对几种革兰氏阴性菌的培养有效。在中等浓度下，它对葡萄球菌和厌氧菌有活性。
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引用次数: 39
Isotonic Solutions XI*
Journal of the American Pharmaceutical Association (Scientific ed.)
Pub Date : 1960-11-01 DOI: 10.1002/jps.3030491107
Edward P. Winters , William J. Husa

The effects of various sympathomimetic amine salts and phenothiazine derivatives in preventing hemolysis of human erythrocytes were studied. In some instances rabbit erythrocytes were used. The results indicated that in solutions of increasing concentrations of sympathomimetic amine salts, hemolysis initially decreased, then abruptly increased, followed by a second greater decrease and increase. In the presence of 0.6 per cent sodium chloride there was no hemolysis until a certain concentration of sympathomimetic amine salt was reached, which closely coincided with the concentration of the same drug that resulted in the final increase in hemolysis when sodium chloride was not present. Freezing point depressions and pH values of the compounds employed in the hemolytic method were determined. The compounds were tested for reactions with human serum and oxyhemoglobin. The phenothiazine derivatives tested were found to be unsuited for investigation by the hemolytic method.

研究了各种拟交感胺盐和吩噻嗪衍生物对人红细胞溶血的预防作用。在某些情况下，使用兔红细胞。结果表明，在增加拟交感神经胺盐浓度的溶液中，溶血开始减少，然后突然增加，随后第二次更大的减少和增加。在存在0.6%氯化钠的情况下，没有溶血，直到达到一定浓度的拟交感胺盐，这与不存在氯化钠时导致溶血最终增加的同一药物的浓度密切吻合。测定了溶血法中所用化合物的冰点下降和pH值。测试了这些化合物与人血清和氧合血红蛋白的反应。发现所测吩噻嗪衍生物不适合溶血法研究。
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引用次数: 2
Note on a Revised Sugar Coating Procedure for Tablets* 关于片剂糖衣工序的修订说明*
Journal of the American Pharmaceutical Association (Scientific ed.)
Pub Date : 1960-11-01 DOI: 10.1002/jps.3030491117
S.J. Tucker, A.B. Rednick

A method is presented which describes a revised sugar coating procedure. The procedure eliminates the rounding and smoothing operations usually employed in pan-coated tablets. The resulting coating is approximately one-half as thick as the standard method and coating time is greatly reduced.

提出了一种改进的糖衣工艺。该程序消除了通常在pan-coated片剂中使用的舍入和平滑操作。所得涂层厚度约为标准方法的一半，涂层时间大大减少。
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引用次数: 0
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