Pub Date : 2022-03-28DOI: 10.1101/2022.03.28.486075
Lianghui Zhang, Krishna K Narayanan, Laura Cooper, Kui K Chan, Christine A Devlin, Aaron Aguhob, Kristie Shirley, Lijun Rong, Jalees Rehman, Asrar B Malik, Erik Procko
Monoclonal antibodies targeting the SARS-CoV-2 spike (S) glycoprotein neutralize infection and are efficacious for the treatment of mild-to-moderate COVID-19. However, SARS-CoV-2 variants have emerged that partially or fully escape monoclonal antibodies in clinical use. Notably, the BA.2 sublineage of B.1.1.529/omicron escapes nearly all monoclonal antibodies currently authorized for therapeutic treatment of COVID-19. Decoy receptors, which are based on soluble forms of the host entry receptor ACE2, are an alternative strategy that broadly bind and block S from SARS-CoV-2 variants and related betacoronaviruses. The high-affinity and catalytically active decoy sACE2 2 .v2.4-IgG1 was previously shown to be effective in vivo against SARS-CoV-2 variants when administered intravenously. Here, the inhalation of sACE2 2 .v2.4-IgG1 is found to increase survival and ameliorate lung injury in K18-hACE2 transgenic mice inoculated with a lethal dose of the virulent P.1/gamma virus. Loss of catalytic activity reduced the decoy’s therapeutic efficacy supporting dual mechanisms of action: direct blocking of viral S and turnover of ACE2 substrates associated with lung injury and inflammation. Binding of sACE2 2 .v2.4-IgG1 remained tight to S of BA.1 omicron, despite BA.1 omicron having extensive mutations, and binding exceeded that of four monoclonal antibodies approved for clinical use. BA.1 pseudovirus and authentic virus were neutralized at picomolar concentrations. Finally, tight binding was maintained against S from the BA.2 omicron sublineage, which differs from S of BA.1 by 26 mutations. Overall, the therapeutic potential of sACE2 2 .v2.4-IgG1 is further confirmed by inhalation route and broad neutralization potency persists against increasingly divergent SARS-CoV-2 variants.
{"title":"An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2.","authors":"Lianghui Zhang, Krishna K Narayanan, Laura Cooper, Kui K Chan, Christine A Devlin, Aaron Aguhob, Kristie Shirley, Lijun Rong, Jalees Rehman, Asrar B Malik, Erik Procko","doi":"10.1101/2022.03.28.486075","DOIUrl":"10.1101/2022.03.28.486075","url":null,"abstract":"<p><p>Monoclonal antibodies targeting the SARS-CoV-2 spike (S) glycoprotein neutralize infection and are efficacious for the treatment of mild-to-moderate COVID-19. However, SARS-CoV-2 variants have emerged that partially or fully escape monoclonal antibodies in clinical use. Notably, the BA.2 sublineage of B.1.1.529/omicron escapes nearly all monoclonal antibodies currently authorized for therapeutic treatment of COVID-19. Decoy receptors, which are based on soluble forms of the host entry receptor ACE2, are an alternative strategy that broadly bind and block S from SARS-CoV-2 variants and related betacoronaviruses. The high-affinity and catalytically active decoy sACE2 <sub>2</sub> .v2.4-IgG1 was previously shown to be effective in vivo against SARS-CoV-2 variants when administered intravenously. Here, the inhalation of sACE2 <sub>2</sub> .v2.4-IgG1 is found to increase survival and ameliorate lung injury in K18-hACE2 transgenic mice inoculated with a lethal dose of the virulent P.1/gamma virus. Loss of catalytic activity reduced the decoy’s therapeutic efficacy supporting dual mechanisms of action: direct blocking of viral S and turnover of ACE2 substrates associated with lung injury and inflammation. Binding of sACE2 <sub>2</sub> .v2.4-IgG1 remained tight to S of BA.1 omicron, despite BA.1 omicron having extensive mutations, and binding exceeded that of four monoclonal antibodies approved for clinical use. BA.1 pseudovirus and authentic virus were neutralized at picomolar concentrations. Finally, tight binding was maintained against S from the BA.2 omicron sublineage, which differs from S of BA.1 by 26 mutations. Overall, the therapeutic potential of sACE2 <sub>2</sub> .v2.4-IgG1 is further confirmed by inhalation route and broad neutralization potency persists against increasingly divergent SARS-CoV-2 variants.</p>","PeriodicalId":10094,"journal":{"name":"中华医学美学美容杂志","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85989828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-15DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.06.019
Liu Liu, Haitao Wang, Huizheng Li, Xingjian Cheng, Lei Yang
Objective Microtia is a relatively common birth defect, and its etiology is still unclear. In this paper, Phenolyzer, a kind of phenotype-based gene analyzer, was used to prioritize candidate genes involved in microtia. Methods The search term " Microtia" was entered in the Phenolyzer interface. Through the steps of disease matching, gene query, gene scoring, seed gene expansion, the genetic information results of microtia were finally generated. This article traced 10 candidate genes in detail. Results There were 13485 genes associated with microtia or related syndromes, of which 130 were seed genes. Each gene had a corresponding score, and the higher the score, the greater the correlation with the microtia. Among them, the top 10 genes included HOXA2, CHD7, CDT1, CDC6, ORC1, ORC4, ORC6, SMAD4, GLI3 and MED12. Conclusions Phenolyzer provides a detailed summary of candidate genes for microtia, providing accurate research directions for screening high-throughput sequencing results and subsequent studies. Key words: Microtia; Gene; Prioritization; Phenolyzer
{"title":"Phenotype-based gene analyzer applied to the genetics of microtia","authors":"Liu Liu, Haitao Wang, Huizheng Li, Xingjian Cheng, Lei Yang","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.06.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.06.019","url":null,"abstract":"Objective \u0000Microtia is a relatively common birth defect, and its etiology is still unclear. In this paper, Phenolyzer, a kind of phenotype-based gene analyzer, was used to prioritize candidate genes involved in microtia. \u0000 \u0000 \u0000Methods \u0000The search term \" Microtia\" was entered in the Phenolyzer interface. Through the steps of disease matching, gene query, gene scoring, seed gene expansion, the genetic information results of microtia were finally generated. This article traced 10 candidate genes in detail. \u0000 \u0000 \u0000Results \u0000There were 13485 genes associated with microtia or related syndromes, of which 130 were seed genes. Each gene had a corresponding score, and the higher the score, the greater the correlation with the microtia. Among them, the top 10 genes included HOXA2, CHD7, CDT1, CDC6, ORC1, ORC4, ORC6, SMAD4, GLI3 and MED12. \u0000 \u0000 \u0000Conclusions \u0000Phenolyzer provides a detailed summary of candidate genes for microtia, providing accurate research directions for screening high-throughput sequencing results and subsequent studies. \u0000 \u0000 \u0000Key words: \u0000Microtia; Gene; Prioritization; Phenolyzer","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"512-515"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46490269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-15DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.06.012
Jian Zhang, W. Liang, Jinming Zhang, Jiaqi Zhang, Xiaolian Xiao, Zheng Su
Objective To explore the feasibility and clinical effect of autologous fat concentrate combined with split-thickness skin grafts in the repair of venous ulcer. Methods From January 2015 to December 2018, a total of 16 patients diagnosed with venous ulcer were admitted to our department, and all patients received symptomatic and supportive treatment such as local debridement and dressing change. After the granulation tissue grew well, all patients received autologous adipose concentrate combined with spilit-thickness skin graft for repair. Results All the grafted skin survived well, and the survival rate of grafted skin at 2 weeks after surgery was 86% to 99%. All patients were followed up to 6 months after surgery. The wounds of all patients were healed during the follow-up period. One patient suffered local ulcer recurrence due to repeated friction after healing and the ulcer recovered after dressing changing treatment. All the other patients had no recurrence during the follow-up period. The scar hyperplasia in the skin transplantation area was not obvious and the healing quality was good. No significant surgical complications occurred. Conclusions Autologous lipoconcentrate combined with split-thickness skin grafts is an effective and safe method in the repair of venous ulcer, and the application of autologous lipoconcentrate can effectively improve the survival rate and healing quality of skin grafts. Key words: Ulcer; Veins; Reconstructive surgical procedures; Auto lipo-concentrate; Split-thickness skin graft
{"title":"Application of autogenous adipose concentrate combined with split-thickness skin graft in repair of venous ulcer","authors":"Jian Zhang, W. Liang, Jinming Zhang, Jiaqi Zhang, Xiaolian Xiao, Zheng Su","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.06.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.06.012","url":null,"abstract":"Objective \u0000To explore the feasibility and clinical effect of autologous fat concentrate combined with split-thickness skin grafts in the repair of venous ulcer. \u0000 \u0000 \u0000Methods \u0000From January 2015 to December 2018, a total of 16 patients diagnosed with venous ulcer were admitted to our department, and all patients received symptomatic and supportive treatment such as local debridement and dressing change. After the granulation tissue grew well, all patients received autologous adipose concentrate combined with spilit-thickness skin graft for repair. \u0000 \u0000 \u0000Results \u0000All the grafted skin survived well, and the survival rate of grafted skin at 2 weeks after surgery was 86% to 99%. All patients were followed up to 6 months after surgery. The wounds of all patients were healed during the follow-up period. One patient suffered local ulcer recurrence due to repeated friction after healing and the ulcer recovered after dressing changing treatment. All the other patients had no recurrence during the follow-up period. The scar hyperplasia in the skin transplantation area was not obvious and the healing quality was good. No significant surgical complications occurred. \u0000 \u0000 \u0000Conclusions \u0000Autologous lipoconcentrate combined with split-thickness skin grafts is an effective and safe method in the repair of venous ulcer, and the application of autologous lipoconcentrate can effectively improve the survival rate and healing quality of skin grafts. \u0000 \u0000 \u0000Key words: \u0000Ulcer; Veins; Reconstructive surgical procedures; Auto lipo-concentrate; Split-thickness skin graft","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"485-487"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43812383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-15DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.06.007
Tao Yang, Liqiang Liu, Yi-min Song
Objective To explore the application of the technique of eyelid lift combined with eyebrow arch augmentation in the correction of upper eyelid skin ptosis. Methods The incision was taken below or above the eyebrow, the superficial epithelium removed from the skin area with subcutaneous dermis and fascia preserved; the eyebrow skin flap was separated from the underlying muscles plane through the incision near the eyebrow and to expose the muscle superior to the eyebrow arch. The reserved dermis and fascia flap was folded and fixed to the muscle near the eyebrow arch area. Results Using this method we corrected 186 patients with upper eyelid skin relaxation from August 2008 to October 2018, including 178 females and 8 males. 52 patients were followed up from 6 to 50 months post operation. All the incision healed well with improved skin lift and augmented eyebrow arch, the incision scar were almost invisible. 45 patients were very satisfied with their appearance; asymmetry was encountered in 3 cases and 2 of them experienced revision surgery. 3 patients were not satisfied with the insufficient skin lift. 1 case was complaint of her unilateral dog ear in the early stage post operation. Conclusions This technique can augment the low eyebrow arch while improve the upper eyelid ptosis. The preserved dermis and fascia folding technique can also reduce the incision tension and obtain a invisible incision scar as a result. Key words: Eyelids; Skin aging; Dermis and fascia muscle; Muscle suspension; Eyelid skin ptosis
{"title":"Application of suspension technique between dermal fascia and frontalis in upper lid lift and eyebrow augmentation","authors":"Tao Yang, Liqiang Liu, Yi-min Song","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.06.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.06.007","url":null,"abstract":"Objective \u0000To explore the application of the technique of eyelid lift combined with eyebrow arch augmentation in the correction of upper eyelid skin ptosis. \u0000 \u0000 \u0000Methods \u0000The incision was taken below or above the eyebrow, the superficial epithelium removed from the skin area with subcutaneous dermis and fascia preserved; the eyebrow skin flap was separated from the underlying muscles plane through the incision near the eyebrow and to expose the muscle superior to the eyebrow arch. The reserved dermis and fascia flap was folded and fixed to the muscle near the eyebrow arch area. \u0000 \u0000 \u0000Results \u0000Using this method we corrected 186 patients with upper eyelid skin relaxation from August 2008 to October 2018, including 178 females and 8 males. 52 patients were followed up from 6 to 50 months post operation. All the incision healed well with improved skin lift and augmented eyebrow arch, the incision scar were almost invisible. 45 patients were very satisfied with their appearance; asymmetry was encountered in 3 cases and 2 of them experienced revision surgery. 3 patients were not satisfied with the insufficient skin lift. 1 case was complaint of her unilateral dog ear in the early stage post operation. \u0000 \u0000 \u0000Conclusions \u0000This technique can augment the low eyebrow arch while improve the upper eyelid ptosis. The preserved dermis and fascia folding technique can also reduce the incision tension and obtain a invisible incision scar as a result. \u0000 \u0000 \u0000Key words: \u0000Eyelids; Skin aging; Dermis and fascia muscle; Muscle suspension; Eyelid skin ptosis","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"468-470"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43098410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-15DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.06.015
Sheng-chang Zhang, E. Pan, Jian-gang Yu, Feng Lu
Objective To introduce the SVF-gel as a filling, and the application of SVF-gel for the treatment of horizontal neck wrinkles. Methods This investigation presented a retrospective study of 30 patients (age ranged from 25 to 56 years, with mean 36 years) in Guangzhou Eye-Nose-Fat Cosmetic Plastic Clinic from December 2017 to June 2019. We used the SVF-gel injection for horizontal neck wrinkles for the patients. The effectiveness was observed 1 to 6 months later. Results No serious complications occurred in all patients. Postoperative evaluation of horizontal neck wrinkles showed that the swelling time lasted for 1-3 days, and the satisfactory rate of the doctors and patients after one month was 83.33% and 86.67%, and that after 6 months was 86.67 % and 83.33%, respectively. Conclusions SVF-gel is an effective treatment for horizontal neck wrinkles. Key words: Neck; Horizontal wrinkles; SVF; Injection; Rejuvenation
{"title":"Clinical effectiveness of SVF-gel injection for horizontal neck wrinkles","authors":"Sheng-chang Zhang, E. Pan, Jian-gang Yu, Feng Lu","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.06.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.06.015","url":null,"abstract":"Objective \u0000To introduce the SVF-gel as a filling, and the application of SVF-gel for the treatment of horizontal neck wrinkles. \u0000 \u0000 \u0000Methods \u0000This investigation presented a retrospective study of 30 patients (age ranged from 25 to 56 years, with mean 36 years) in Guangzhou Eye-Nose-Fat Cosmetic Plastic Clinic from December 2017 to June 2019. We used the SVF-gel injection for horizontal neck wrinkles for the patients. The effectiveness was observed 1 to 6 months later. \u0000 \u0000 \u0000Results \u0000No serious complications occurred in all patients. Postoperative evaluation of horizontal neck wrinkles showed that the swelling time lasted for 1-3 days, and the satisfactory rate of the doctors and patients after one month was 83.33% and 86.67%, and that after 6 months was 86.67 % and 83.33%, respectively. \u0000 \u0000 \u0000Conclusions \u0000SVF-gel is an effective treatment for horizontal neck wrinkles. \u0000 \u0000 \u0000Key words: \u0000Neck; Horizontal wrinkles; SVF; Injection; Rejuvenation","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"496-499"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48499401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-15DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.06.006
Yanming Jiang, Bo Yu, Yongmin Wang, Wanqiang Li, Zhigang Zhang, Z. Shao
Objective To observe the clinical effect of the modified bandaging method for facial rejuvenation with small incision and to explore its applicable scope. Methods From March to October 2019, 12 people in the outpatient department underwent small incision facial rejuvenation surgery and the improved bandaging method was used. Results After the small incision facial rejuvenation operation, the relaxation and drooping of the facial tissue in 12 patients were significantly improved without complications, and no cotton pad, bandage and elastic mesh cover were used for fixation. Conclusions This improved bandaging method does not affect daily work and life, and meets the needs of patients with this requirement, and plays a very good role in promoting the small incision facial rejuvenation surgery. Key words: Small incision; Facial rejuvenation surgery; Improvement; Bandage; Effect
{"title":"Effect of modified bandaging method on facial rejuvenation with small incision","authors":"Yanming Jiang, Bo Yu, Yongmin Wang, Wanqiang Li, Zhigang Zhang, Z. Shao","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.06.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.06.006","url":null,"abstract":"Objective \u0000To observe the clinical effect of the modified bandaging method for facial rejuvenation with small incision and to explore its applicable scope. \u0000 \u0000 \u0000Methods \u0000From March to October 2019, 12 people in the outpatient department underwent small incision facial rejuvenation surgery and the improved bandaging method was used. \u0000 \u0000 \u0000Results \u0000After the small incision facial rejuvenation operation, the relaxation and drooping of the facial tissue in 12 patients were significantly improved without complications, and no cotton pad, bandage and elastic mesh cover were used for fixation. \u0000 \u0000 \u0000Conclusions \u0000This improved bandaging method does not affect daily work and life, and meets the needs of patients with this requirement, and plays a very good role in promoting the small incision facial rejuvenation surgery. \u0000 \u0000 \u0000Key words: \u0000Small incision; Facial rejuvenation surgery; Improvement; Bandage; Effect","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"465-467"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42325022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-15DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.06.005
Min-chao Zhao, Dandan Wang
Objective To observe the effect of modified myocutaneous flaps in the treatment of lower eyelid relaxation. Methods From June 2017 to November 2018, 85 patients with lower eyelid relaxation were treated in our hospital. Modified musculocutaneous flaps were used in all cases. The techniques of preservation of eye fur, treatment of lacrimal grooves and muscle resection and suture were emphasized during the operation. All patients were followed up for 6 months to observe the occurrence of complications. At 6 months after operation, the satisfaction of operation was evaluated. Results After 6 months of follow-up, 79 cases (92.94%) were satisfied. The symptoms included the disappearance of lower eyelid skin relaxation, the disappearance of lower eyelid margin baggy groove, no eyelid retraction, the formation of " orbicularis oculi muscle threshold" on the eyelid margin, and no obvious scar. There were 6 cases of basic satisfaction and 0 cases of unsatisfactory. Two patients had mild eyelid ectropion, 2 patients had slight scar hyperplasia at the lateral canthus incision, and no complications such as retrobulbar hematoma, infection and facial nerve injury occurred. No second repair operation was performed. Conclusions Modified musculocutaneous flaps have a satisfactory effect in the treatment of lower eyelid skin relaxation. It not only takes into account the advantages of the two traditional methods of skin flaps and musculocutaneous flaps, but also retains the natural physiological curvature of eye fur. It can also significantly improve the wrinkles and lacrimal grooves of lower eyelid. It is worthy popularizing. Key words: Eyelids; Skin aging; Modified myocutaneous flaps; Lower eyelid relaxation correction
{"title":"Effect of modified myocutaneous flaps in treatment of lower eyelid relaxation","authors":"Min-chao Zhao, Dandan Wang","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.06.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.06.005","url":null,"abstract":"Objective \u0000To observe the effect of modified myocutaneous flaps in the treatment of lower eyelid relaxation. \u0000 \u0000 \u0000Methods \u0000From June 2017 to November 2018, 85 patients with lower eyelid relaxation were treated in our hospital. Modified musculocutaneous flaps were used in all cases. The techniques of preservation of eye fur, treatment of lacrimal grooves and muscle resection and suture were emphasized during the operation. All patients were followed up for 6 months to observe the occurrence of complications. At 6 months after operation, the satisfaction of operation was evaluated. \u0000 \u0000 \u0000Results \u0000After 6 months of follow-up, 79 cases (92.94%) were satisfied. The symptoms included the disappearance of lower eyelid skin relaxation, the disappearance of lower eyelid margin baggy groove, no eyelid retraction, the formation of \" orbicularis oculi muscle threshold\" on the eyelid margin, and no obvious scar. There were 6 cases of basic satisfaction and 0 cases of unsatisfactory. Two patients had mild eyelid ectropion, 2 patients had slight scar hyperplasia at the lateral canthus incision, and no complications such as retrobulbar hematoma, infection and facial nerve injury occurred. No second repair operation was performed. \u0000 \u0000 \u0000Conclusions \u0000Modified musculocutaneous flaps have a satisfactory effect in the treatment of lower eyelid skin relaxation. It not only takes into account the advantages of the two traditional methods of skin flaps and musculocutaneous flaps, but also retains the natural physiological curvature of eye fur. It can also significantly improve the wrinkles and lacrimal grooves of lower eyelid. It is worthy popularizing. \u0000 \u0000 \u0000Key words: \u0000Eyelids; Skin aging; Modified myocutaneous flaps; Lower eyelid relaxation correction","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"462-464"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41650586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-15DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.06.020
Ye Zhao, Jingyu Li, Lei Zhang, Tingting Jin, Ce Zhang
Objective To study the characteristics of sentinel vein (SV) and middle temporal vein (MTV) and influence in surgery of periorbital and temporal areas. Methods From January 2018 to August 2019, 20 donated fresh/frozen head specimens (12 males and 8 females) were collected in various regions of China, with an average age of 47.2 (21 to 88) years. Temporal region of 29 hemi-facial area was dissected in layers, and the occurrence rate, route, geometric parameters, branchesand correlation of SV and MTV were observed and measured. Results Occurrence rate of SV was 96.6% (28/29), the subcutaneous subordinate branches of SV were 2.5±1.0 in average, with both joining together in 6 kinds of mode. The horizontal section length was (5.8±3.8) mm, and outside diameter was (1.0±0.1) mm. The vertical section length was (8.2±4.3) mm, and outside diameter was (1.2±0.4) mm, steering vertically to the deep through the superficial temporal fascia, middle temporal fascia (MTF) and superficial layer of deep temporal fascia (SDTF), continuing to the MTV. The minimal average distance between the SV and TFN was (6.0±2.7) mm. Occurrence rate of MTV was 96.6% (28/29). The first half of MTV was parallel to the zygomatic arch and ran across the superficial temporal fat pad, then turned down near the upper pole of the external ear wheel, and run vertically in front of the ear, and 5.9±2.7 peripheral branches were collected along the way. The length of temporal middle vein was (82.3±8.6) mm, and outer diameter of the thickest point was (3.6±0.7) mm. Conclusions Sentinel vein is the main branch of middle temporal vein. It passes through several layers of soft tissue vertically and directly into the MTV. Position of sentinel vein is relatively constant, which is an important localization marker in the operation of the temporal region. The middle temporal vein has large diameter, fixing in the superficial temporal fat pad, collecting the venous reflux of the temporal area at both superficial and deep, which may be the main cause of pulmonary infarction produced by the temporal fat transplantation, and injury should be avoided. Key words: Autopsy; Middle temporal vein; Sentinel vein; Temporalanatomy; Filler injection
{"title":"Sentinel vein and middle temporal vein in Chinese: an anatomic study","authors":"Ye Zhao, Jingyu Li, Lei Zhang, Tingting Jin, Ce Zhang","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.06.020","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.06.020","url":null,"abstract":"Objective \u0000To study the characteristics of sentinel vein (SV) and middle temporal vein (MTV) and influence in surgery of periorbital and temporal areas. \u0000 \u0000 \u0000Methods \u0000From January 2018 to August 2019, 20 donated fresh/frozen head specimens (12 males and 8 females) were collected in various regions of China, with an average age of 47.2 (21 to 88) years. Temporal region of 29 hemi-facial area was dissected in layers, and the occurrence rate, route, geometric parameters, branchesand correlation of SV and MTV were observed and measured. \u0000 \u0000 \u0000Results \u0000Occurrence rate of SV was 96.6% (28/29), the subcutaneous subordinate branches of SV were 2.5±1.0 in average, with both joining together in 6 kinds of mode. The horizontal section length was (5.8±3.8) mm, and outside diameter was (1.0±0.1) mm. The vertical section length was (8.2±4.3) mm, and outside diameter was (1.2±0.4) mm, steering vertically to the deep through the superficial temporal fascia, middle temporal fascia (MTF) and superficial layer of deep temporal fascia (SDTF), continuing to the MTV. The minimal average distance between the SV and TFN was (6.0±2.7) mm. Occurrence rate of MTV was 96.6% (28/29). The first half of MTV was parallel to the zygomatic arch and ran across the superficial temporal fat pad, then turned down near the upper pole of the external ear wheel, and run vertically in front of the ear, and 5.9±2.7 peripheral branches were collected along the way. The length of temporal middle vein was (82.3±8.6) mm, and outer diameter of the thickest point was (3.6±0.7) mm. \u0000 \u0000 \u0000Conclusions \u0000Sentinel vein is the main branch of middle temporal vein. It passes through several layers of soft tissue vertically and directly into the MTV. Position of sentinel vein is relatively constant, which is an important localization marker in the operation of the temporal region. The middle temporal vein has large diameter, fixing in the superficial temporal fat pad, collecting the venous reflux of the temporal area at both superficial and deep, which may be the main cause of pulmonary infarction produced by the temporal fat transplantation, and injury should be avoided. \u0000 \u0000 \u0000Key words: \u0000Autopsy; Middle temporal vein; Sentinel vein; Temporalanatomy; Filler injection","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"516-520"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44096856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-15DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.06.017
Song Jia, J. Guan
Objective To evaluate the effect of continuous embedding on the improvement of mild epicanthus by studying the change of intercanthal distance and inner canthus angle in patients perioperatively. Methods In this study, 34 patients with single eyelid and mild epicanthus were analyzed retrospectively. Procedure included small incisions combined with continuous embedding double eyelid surgery. The photo of eyes was taken in the front position preoperatively and postoperatively. Before operation, 3-months, 6 months-after operation, intercanthal distance and inner canthal angle of both eyes were measured by Photoshop CS6. The iris diameter scale was used to measure intercanthal distance. Results Preoperative intercanthal distance (PRICD) values were 65.96±4.94 (iris diameter scale), 3-month-postoperative intercanthal distance (3POICD) values were 63.43±5.04 (iris diameter scale), and 6-month-postoperative intercanthal distance (6POICD) values were 63.82±5.02 (iris diameter distance). Preoperative inner-canthal angle of the left eye (PRCAL) values were (47.51±4.28)°, preoperative inner-canthal angle of the right eye (PRCAR) values were (47.30±4.55)°, 3-month-preoperative inner-canthal angle of the left eye (3POCAL) values were (49.53±5.15)°. 3-month-preoperative inner-canthal angle of the right eye (3POCAR) values were (49.24±4.86)°, 6 month-postperative inner-canthal angle of the left eye (6POCAL) values were (49.48±4.74)°, and 6 month-postperative inner-canthal angle of the right eye (6POCAR) values were (48.99±4.55)°. The difference between PRICD and 3POICD, PRICD and 6POICD, PRCAL and 3POCAL, PRCAL and 6POCAL, PRCAR and 3POCAR, PRCAR and 6POCAR were statistically significant (t=6.432, 6.307, -2.882, -3.188, -2.516, -2.248, P 0.05). Conclusions According to the result of the study, the continuous embedding method has a certain effect on shortening the intercanthal distance and changing the inner canthal angle. It is inferred that the continuous embedding method has a certain effect on the improvement of mild epicanthus. Key words: Ophthalmologic surgical procedures; Iris; Embedding double eyelids surgery; Epicanthus; Iris diameter scale
{"title":"Improvement of mild epicanthus treated by continuous embedding method","authors":"Song Jia, J. Guan","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.06.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.06.017","url":null,"abstract":"Objective \u0000To evaluate the effect of continuous embedding on the improvement of mild epicanthus by studying the change of intercanthal distance and inner canthus angle in patients perioperatively. \u0000 \u0000 \u0000Methods \u0000In this study, 34 patients with single eyelid and mild epicanthus were analyzed retrospectively. Procedure included small incisions combined with continuous embedding double eyelid surgery. The photo of eyes was taken in the front position preoperatively and postoperatively. Before operation, 3-months, 6 months-after operation, intercanthal distance and inner canthal angle of both eyes were measured by Photoshop CS6. The iris diameter scale was used to measure intercanthal distance. \u0000 \u0000 \u0000Results \u0000Preoperative intercanthal distance (PRICD) values were 65.96±4.94 (iris diameter scale), 3-month-postoperative intercanthal distance (3POICD) values were 63.43±5.04 (iris diameter scale), and 6-month-postoperative intercanthal distance (6POICD) values were 63.82±5.02 (iris diameter distance). Preoperative inner-canthal angle of the left eye (PRCAL) values were (47.51±4.28)°, preoperative inner-canthal angle of the right eye (PRCAR) values were (47.30±4.55)°, 3-month-preoperative inner-canthal angle of the left eye (3POCAL) values were (49.53±5.15)°. 3-month-preoperative inner-canthal angle of the right eye (3POCAR) values were (49.24±4.86)°, 6 month-postperative inner-canthal angle of the left eye (6POCAL) values were (49.48±4.74)°, and 6 month-postperative inner-canthal angle of the right eye (6POCAR) values were (48.99±4.55)°. The difference between PRICD and 3POICD, PRICD and 6POICD, PRCAL and 3POCAL, PRCAL and 6POCAL, PRCAR and 3POCAR, PRCAR and 6POCAR were statistically significant (t=6.432, 6.307, -2.882, -3.188, -2.516, -2.248, P 0.05). \u0000 \u0000 \u0000Conclusions \u0000According to the result of the study, the continuous embedding method has a certain effect on shortening the intercanthal distance and changing the inner canthal angle. It is inferred that the continuous embedding method has a certain effect on the improvement of mild epicanthus. \u0000 \u0000 \u0000Key words: \u0000Ophthalmologic surgical procedures; Iris; Embedding double eyelids surgery; Epicanthus; Iris diameter scale","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"504-507"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45049085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-15DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.06.016
Youjing Wang, Weimin Shen, J. Cui, Yi Ji, Hai-ni Chen, Jun Yan, Qingwen Gao, Tao Han
Objective To discuss the application of plane-shaped flaps for reconstruction of the web space in polysyndactyly of the fifth toe fused with the fourth toe. Methods A total of 62 cases (81 feet) with polysyndactyly of the fifth toe fused with the fourth toe were involved in the study, 53 of which were incomplete and 9 were complete fusion of the fourth and fifth toe. The fifth toe showed various degrees of fibular clinodactyly and minor deformities. Excision of polydactyly and then using arthroplasty or osteotomy correction deviation was for fibular clinodactyly. All plane-shaped flaps were used for reconstruction of the web space deeply, and the lateral sides of toes were closed with flaps and the distal soft tissues of polydactyly were used lengthening the reconstructed fifth toe. Brachydactylias were improved, and nail folds were reconstructed. Thus, the appearances reached the normal level. Results All the webs were reconstructed primarily without skingraft. After 12 months of follow-up, these reconstructed web space were satisfied with good appearances of width, depth and gradient. The fibular clinodactyly was completely corrected, and brachydactylias were corrected in various degrees. Nail folds reached the normal ones. Conclusions Plane-shaped flap in polysyndactyly of the fifth toe fused with the fourth toe for reconstruction of the web space is satisfactory. The reconstructed webs not only achieves good appearance, but also avoids skin grafts. It is one of the best choices of the polysyndactyly treatment. Key words: Reconstructive surgical procedures; Child; Polysyndactyly of the toes; Syndactyly; Web space reconstruction; Plane-shaped flap
{"title":"Plane-shaped flap for reconstruction of the web space in polysyndactyly of the fifth toe fused with the fourth toe","authors":"Youjing Wang, Weimin Shen, J. Cui, Yi Ji, Hai-ni Chen, Jun Yan, Qingwen Gao, Tao Han","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.06.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.06.016","url":null,"abstract":"Objective \u0000To discuss the application of plane-shaped flaps for reconstruction of the web space in polysyndactyly of the fifth toe fused with the fourth toe. \u0000 \u0000 \u0000Methods \u0000A total of 62 cases (81 feet) with polysyndactyly of the fifth toe fused with the fourth toe were involved in the study, 53 of which were incomplete and 9 were complete fusion of the fourth and fifth toe. The fifth toe showed various degrees of fibular clinodactyly and minor deformities. Excision of polydactyly and then using arthroplasty or osteotomy correction deviation was for fibular clinodactyly. All plane-shaped flaps were used for reconstruction of the web space deeply, and the lateral sides of toes were closed with flaps and the distal soft tissues of polydactyly were used lengthening the reconstructed fifth toe. Brachydactylias were improved, and nail folds were reconstructed. Thus, the appearances reached the normal level. \u0000 \u0000 \u0000Results \u0000All the webs were reconstructed primarily without skingraft. After 12 months of follow-up, these reconstructed web space were satisfied with good appearances of width, depth and gradient. The fibular clinodactyly was completely corrected, and brachydactylias were corrected in various degrees. Nail folds reached the normal ones. \u0000 \u0000 \u0000Conclusions \u0000Plane-shaped flap in polysyndactyly of the fifth toe fused with the fourth toe for reconstruction of the web space is satisfactory. The reconstructed webs not only achieves good appearance, but also avoids skin grafts. It is one of the best choices of the polysyndactyly treatment. \u0000 \u0000 \u0000Key words: \u0000Reconstructive surgical procedures; Child; Polysyndactyly of the toes; Syndactyly; Web space reconstruction; Plane-shaped flap","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"500-503"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46186619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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