Nano TransMed最新文献_第3页

Selenium, silver, and gold nanoparticles: Emerging strategies for hepatic oxidative stress and inflammation reduction 硒，银和金纳米颗粒：肝脏氧化应激和炎症减少的新策略

Nano TransMed

Pub Date : 2025-05-07 DOI: 10.1016/j.ntm.2025.100085

Karthik K Karunakar , Binoy Varghese Cheriyan , Dheena Babu , Devan P , Nandhini J , Suresh Kannan M , Lincy Yabase , Kunal Kataria

Liver failure, primarily driven by oxidative stress and inflammation, remains a significant clinical challenge. Conventional hepatoprotective strategies often fail to provide effective long-term protection, necessitating the exploration of novel therapeutic approaches. This review focuses on the hepatoprotective potential of selenium (SeNPs), silver (AgNPs), and gold nanoparticles (AuNPs), emphasizing their antioxidant, anti-inflammatory, and immunomodulatory mechanisms. SeNPs enhance antioxidant defenses by scavenging reactive oxygen species (ROS) and upregulating key enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx). AgNPs exhibit anti-inflammatory effects by modulating cytokine expression, reducing lipid peroxidation, and preserving hepatic architecture. AuNPs demonstrate biocompatibility, fibrosis prevention, and immune modulation through NF-κB and Nrf2 signaling. Despite their therapeutic promise, concerns regarding nanoparticle biocompatibility, stability, and potential toxicity remain key challenges for clinical translation. This review aims to explore the role of (SeNPs), (AgNPs), and (AuNPs) in mitigating oxidative stress and inflammation in liver diseases, explore their mechanisms of hepatoprotection, assess the challenges associated with their biomedical applications, and provide insights into future directions for their clinical development. Addressing these gaps will be crucial in optimizing nanoparticle-based hepatoprotective therapies for safer and more effective liver disease management.

肝衰竭，主要是由氧化应激和炎症引起的，仍然是一个重大的临床挑战。传统的肝保护策略往往不能提供有效的长期保护，需要探索新的治疗方法。本文综述了硒纳米粒子（SeNPs）、银纳米粒子（AgNPs）和金纳米粒子（AuNPs）的肝保护潜力，重点介绍了它们的抗氧化、抗炎和免疫调节机制。SeNPs通过清除活性氧（ROS）和上调超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）等关键酶来增强抗氧化防御能力。AgNPs通过调节细胞因子表达、减少脂质过氧化和保护肝脏结构表现出抗炎作用。AuNPs通过NF-κB和Nrf2信号传导表现出生物相容性、纤维化预防和免疫调节。尽管纳米颗粒具有治疗前景，但对其生物相容性、稳定性和潜在毒性的担忧仍然是临床转化的关键挑战。本文旨在探讨（SeNPs）、（AgNPs）和（AuNPs）在肝脏疾病中减轻氧化应激和炎症的作用，探讨其保护肝脏的机制，评估其生物医学应用相关的挑战，并为其临床发展方向提供见解。解决这些差距对于优化基于纳米颗粒的肝保护疗法以实现更安全和更有效的肝病管理至关重要。

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引用次数: 0

Liquid biopsy based on EV biomarkers: A new frontier for early diagnosis and prognosis assessment of cancer at ESMO 2024 基于EV生物标志物的液体活检：癌症早期诊断和预后评估的新前沿

Nano TransMed

Pub Date : 2025-05-06 DOI: 10.1016/j.ntm.2025.100084

Zeping Shan , Xinming Su , Luqing Liu, Shiwei Duan

Extracellular vesicles (EVs) are emerging as powerful biomarkers in liquid biopsy, offering insights into early cancer diagnosis, precision treatment, and prognosis evaluation. EVs, including microvesicles, exosomes, and apoptotic bodies, carry molecular cargo that reflects the physiological or pathological state of parent cells. Recent research, including findings presented at the 2024 European Society for Medical Oncology (ESMO) meeting, highlights significant advances in using EVs for early detection and prognosis in some solid tumors. While applications hold great potential, challenges remain, including the need for advanced technologies for efficient EV separation and purification, characterizing heterogeneity, detecting single EV markers, and overcoming small sample sizes. Addressing these issues will require increased technical investment, collaborative efforts, and large-scale clinical trials. These steps are essential to overcome the current limitations and to promote the application and development of EV-based approaches in cancer diagnosis and treatment.

细胞外囊泡（EVs）正在成为液体活检中强有力的生物标志物，为早期癌症诊断、精确治疗和预后评估提供了新的见解。包括微囊泡、外泌体和凋亡小体在内的ev携带反映亲本细胞生理或病理状态的分子货物。最近的研究，包括在2024年欧洲医学肿瘤学会（ESMO）会议上发表的研究结果，强调了在一些实体肿瘤中使用ev进行早期检测和预后的重大进展。虽然应用潜力巨大，但挑战依然存在，包括对高效EV分离和纯化、表征异质性、检测单个EV标记以及克服小样本量的先进技术的需求。解决这些问题需要增加技术投资、合作努力和大规模临床试验。这些步骤对于克服目前的限制和促进基于ev的方法在癌症诊断和治疗中的应用和发展至关重要。

引用次数: 0

Nanoparticles for drug delivery: Insight into in vitro and in vivo drug release from nanomedicines 用于药物递送的纳米颗粒：纳米药物在体外和体内的药物释放

Nano TransMed

Pub Date : 2025-04-24 DOI: 10.1016/j.ntm.2025.100083

Ugochi E. Ewii , Anthony A. Attama , Emmanuel O. Olorunsola , Adaeze Linda Onugwu , Fortune Uchechukwu Nwakpa , Chioma Anyiam , Chinonye Chijioke , Toochukwu Ogbulie

Nanotechnology enables the achievement of the desired outcomes of nano-formulations, and the mode of drug delivery from the nanoparticles can significantly impact the efficacy of the embedded drug. This article reviews the various types of nanoparticles, methods of evaluating the drug release, in vitro-in vivo correlation, and regulatory challenges associated with nano-formulations. Nanoparticles have been classified into organic, inorganic, and hybrid nanoparticles. Several techniques, such as separated flow, continuous flow, and dialysis methods, have been utilized to assess nano-formulations' in vitro release. In vivo drug release evaluations in biological systems have also been demonstrated. Such evaluations often involve experimental models for the distribution of the nanoparticles, hematology, clearance, histopathology, and serum chemistry. Protein binding, enzymatic degradation, lipid absorption, carbohydrate absorption, and attachment to nucleic acid are some factors shown to affect drug release. In vitro-in-vivo correlation (IVIVC) involves the analysis of the drug release results and mathematical correlations. Factors such as the physicochemical properties of the nanoformulations, the subject’s physiological properties, and the formulation’s biopharmaceutical properties relative to the subject usually affect the correlation. Unlike previous reviews, this article uniquely combines mechanistic insights, production methods, stimuli-responsive systems, and regulatory considerations into a single reference, thereby offering a practical and translational perspective for researchers and formulators. This review also identifies current gaps in IVIVC standardization and highlights opportunities for advancing nanoformulation safety and efficacy.

纳米技术能够实现纳米制剂的预期结果，并且纳米颗粒的药物递送模式可以显著影响嵌入药物的功效。本文综述了各种类型的纳米颗粒，评估药物释放的方法，体内外相关性，以及与纳米制剂相关的监管挑战。纳米粒子分为有机纳米粒子、无机纳米粒子和杂化纳米粒子。几种技术，如分离流、连续流和透析方法，已被用于评估纳米制剂的体外释放。生物系统中的体内药物释放评价也已得到证实。这些评估通常涉及纳米颗粒分布、血液学、清除率、组织病理学和血清化学的实验模型。蛋白质结合、酶降解、脂质吸收、碳水化合物吸收和与核酸的附着是影响药物释放的一些因素。体外体内相关性（IVIVC）包括对药物释放结果和数学相关性的分析。诸如纳米制剂的物理化学性质、受试者的生理性质以及与受试者相关的制剂的生物制药性质等因素通常会影响相关性。与以往的综述不同，本文独特地将机理见解、生产方法、刺激反应系统和监管考虑结合到一个参考文献中，从而为研究人员和配方制定者提供了一个实用和可转化的视角。这篇综述还指出了目前IVIVC标准化方面的差距，并强调了提高纳米制剂安全性和有效性的机会。

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引用次数: 0

Liposome-encapsulated therapies: Precision medicine for inflammatory lung disorders 脂质体包封疗法：炎性肺疾病的精准医学

Nano TransMed

Pub Date : 2025-04-10 DOI: 10.1016/j.ntm.2025.100082

Mohammad Arshad Javed Shaikh , Kavita Goyal , Muhammad Afzal , R. Roopashree , Mukesh Kumari , T. Krithiga , Rajashree Panigrahi , Suman Saini , Haider Ali , Mohd Imran , Abida , Tarun Patodia , Gaurav Gupta

Liposomes have emerged as the preferred choice over other nanocomposites for transporting a wide range of hydrophobic and hydrophilic compounds with therapeutic potential. This is primarily due to their exceptional degradation ability, compatibility within biological systems, and minimal immunogenicity. Liposomes have demonstrated their ability to enhance the solubility and distribution of medications. Moreover, they can undergo surface modifications to enable sustained, prolonged, and targeted release. Inflammatory lung disorders such as asthma, lung cancer, lung damage, tuberculosis, idiopathic pulmonary fibrosis (IPF), and chronic obstructive pulmonary disease (COPD) greatly benefit from liposomes' unique treatment and management qualities. This article provides an overview of the current understanding of liposomal systems' efficacy in drug delivery for managing pulmonary inflammatory diseases.

相对于其他纳米复合材料，脂质体已成为运输具有治疗潜力的各种疏水和亲水化合物的首选。这主要是由于它们特殊的降解能力、生物系统内的相容性和最小的免疫原性。脂质体已经证明了它们增强药物溶解度和分布的能力。此外，它们可以经过表面修饰，以实现持续、延长和有针对性的释放。炎症性肺部疾病，如哮喘、肺癌、肺损伤、肺结核、特发性肺纤维化（IPF）和慢性阻塞性肺疾病（COPD）极大地受益于脂质体独特的治疗和管理品质。本文概述了目前对脂质体系统在治疗肺部炎症性疾病的药物递送中的功效的理解。

引用次数: 0

Boron delivery agents in BNCT: A mini review of current developments and emerging trends 硼在BNCT中的输送剂：目前的发展和新趋势的一个小回顾

Nano TransMed

Pub Date : 2025-04-10 DOI: 10.1016/j.ntm.2025.100081

Rolemae M. Murilla, Gladys G. Edilo, Marco Laurence M. Budlayan, Eulogio S. Auxtero Jr.

Boron Neutron Capture Therapy (BNCT) is a highly targeted form of radiation therapy offering significant potential for treating hard-to-manage cancers such as glioblastoma, head and neck cancer, and recurrent melanoma [1]. Its effectiveness relies on the selective accumulation of boron-10 within tumor cells, enabling localized high-linear-energy transfer (high-LET) damage through neutron capture reactions. Despite the promise of this therapeutic approach, the development of efficient boron delivery agents remains a critical challenge. This review explores the evolution of boron delivery agents over three generations, highlighting their advancements, limitations, and emerging trends. Early first-generation agents, such as sodium tetraborate, faced issues with tumor specificity and retention, leading to the introduction of second-generation agents like boronophenylalanine (BPA) and sodium borocaptate (BSH). While these agents improved therapeutic outcomes, they exhibited limitations in tumor uptake mechanisms, selectivity, and retention. Recent advancements have resulted in third-generation agents that integrate nanotechnology, monoclonal antibodies, and multifunctional frameworks, significantly enhancing tumor specificity and therapeutic efficiency. These innovative agents utilize targeted delivery, imaging capabilities, and theranostic functionalities to optimize treatment outcomes. However, challenges remain in overcoming tumor heterogeneity, ensuring regulatory compliance, and scaling up production. This review provides a comprehensive analysis of current developments in boron delivery systems, offering insights into their potential to transform BNCT into a more effective and accessible cancer therapy.

硼中子俘获疗法（BNCT）是一种高度靶向的放射治疗形式，为治疗难以控制的癌症（如胶质母细胞瘤、头颈癌和复发性黑色素瘤）提供了巨大的潜力。它的有效性依赖于肿瘤细胞内硼-10的选择性积累，通过中子俘获反应实现局部高线能量转移（high-LET）损伤。尽管这种治疗方法有希望，但开发有效的硼输送剂仍然是一个关键的挑战。本文综述了硼递送剂在三代中的发展，重点介绍了它们的进步、局限性和新趋势。早期的第一代药物，如四硼酸钠，面临肿瘤特异性和滞留性的问题，导致第二代药物如硼苯丙氨酸（BPA）和硼硼酸钠（BSH）的引入。虽然这些药物改善了治疗效果，但它们在肿瘤摄取机制、选择性和保留方面表现出局限性。最近的进展导致了第三代药物整合纳米技术，单克隆抗体和多功能框架，显着提高肿瘤特异性和治疗效率。这些创新的药物利用靶向递送、成像能力和治疗功能来优化治疗结果。然而，在克服肿瘤异质性、确保法规遵守和扩大生产方面仍然存在挑战。这篇综述全面分析了硼递送系统的最新进展，提供了将BNCT转变为更有效和更容易获得的癌症治疗方法的潜力。

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引用次数: 0

Eco-friendly nanoparticle phytosynthesis via plant extracts: Mechanistic insights, recent advances, and multifaceted uses 生态友好的纳米颗粒植物合成通过植物提取物：机械的见解，最近的进展，和多方面的用途

Nano TransMed

Pub Date : 2025-03-21 DOI: 10.1016/j.ntm.2025.100080

Great Iruoghene Edo , Alice Njolke Mafe , Ali B.M. Ali , Patrick Othuke Akpoghelie , Emad Yousif , Endurance Fegor Isoje , Ufuoma Augustina Igbuku , Khalid Zainulabdeen , Joseph Oghenewogaga Owheruo , Arthur Efeoghene Athan Essaghah , Huzaifa Umar , Dina S. Ahmed , Ahmed A. Alamiery

This review explores the phytosynthesis of nanoparticles (NPs) using plant extracts, emphasizing mechanistic insights, recent advancements, and their diverse applications. The green and cost-effective nature of phytosynthesis makes it an attractive alternative to conventional nanoparticle synthesis, with phytochemicals such as flavonoids, phenolics, and alkaloids facilitating metal ion reduction and stabilization. The review highlights key medical applications, including the anticancer potential of gold nanoparticles, which have demonstrated apoptosis induction in cancer cells, and their use in theranostic structures for simultaneous diagnosis and treatment. In environmental science, phytosynthesized iron and silver nanoparticles have shown over 90 % efficiency in heavy metal adsorption and pollutant degradation, contributing to sustainable remediation strategies. In agriculture, nanofertilizers synthesized via phytosynthesis have enhanced crop yields by up to 30 % while reducing chemical fertilizer dependence. Despite these advancements, obstacles persist in scaling up production, ensuring batch-to-batch reproducibility, and fully elucidating nanoparticle interactions at the molecular level. Standardizing synthesis protocols, optimizing plant metabolite compositions, and conducting extensive in vivo studies will be crucial in translating laboratory findings into real-world applications. By resolving these difficulties through interdisciplinary collaborations, phytosynthesized nanoparticles can revolutionize nanomedicine, agriculture, and environmental sustainability, paving the way for the next generation of eco-friendly technological innovations.

本文综述了利用植物提取物合成纳米颗粒（NPs）的机理、最新进展及其多种应用。植物合成的绿色和成本效益使其成为传统纳米颗粒合成的一个有吸引力的替代品，其植物化学物质如黄酮类化合物、酚类物质和生物碱有助于金属离子的还原和稳定。这篇综述强调了关键的医学应用，包括金纳米颗粒的抗癌潜力，它已经证明了在癌细胞中诱导细胞凋亡，以及它们在治疗结构中用于同时诊断和治疗。在环境科学方面，植物合成的铁和银纳米颗粒在重金属吸附和污染物降解方面的效率超过90% %，有助于可持续的修复策略。在农业中，通过植物合成合成的纳米肥料使作物产量提高了30% %，同时减少了对化肥的依赖。尽管取得了这些进步，但在扩大生产、确保批对批的可重复性以及在分子水平上充分阐明纳米颗粒相互作用方面仍然存在障碍。标准化合成方案、优化植物代谢物组成以及开展广泛的体内研究对于将实验室发现转化为现实应用至关重要。通过跨学科合作解决这些困难，植物合成纳米颗粒可以彻底改变纳米医学，农业和环境可持续性，为下一代环保技术创新铺平道路。

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引用次数: 0

Application and recent progress of MXene-based bioactive materials in wound management mxeni基生物活性材料在伤口治疗中的应用及最新进展

Nano TransMed

Pub Date : 2025-03-17 DOI: 10.1016/j.ntm.2025.100079

Jiahao Guo , Xiaodong Zhu , Beibei Liang , Xuelian Gu , Cong Wu , Ang Li , Wei Li

Wound management is one of the major challenges in the biomedical field, where wound ulceration and bacterial infections cause systemic inflammatory reactions or scarring in patients, seriously affecting the quality of life and causing great economic pressure. Smart bioactive materials offer new therapeutic strategies for wound management and monitoring, providing a tailored option for wound repair. MXene, as a 2D functional and tunable material, exhibits unique advantages and enormous potential in promoting cell growth, angiogenesis, recruiting immune cells, avoiding infections, and biological signal transmission. This review details the benefits of MXene-based materials in the field of tissue repair and addresses the key challenges faced by different wounds, reflecting excellent bioactivity and organismal suitability. Notably, MXene can function as a smart surrogate device, enabling precise assessments for wound monitoring and care. This development signifies a paradigm shift towards a novel era of non-invasive monitoring of the healing cycle. Nevertheless, strategies for regenerative tissue engineering employing MXene-based materials encounter certain challenges and difficulties, which include ensuring long-term bioactive function, developing novel material types, and meeting individual clinical needs. Finally, the future research directions and technological developments of MXene-based materials in wound management were briefly discussed.

创面管理是生物医学领域的主要挑战之一，创面溃疡和细菌感染会引起患者全身炎症反应或瘢痕形成，严重影响患者的生活质量，造成巨大的经济压力。智能生物活性材料为伤口管理和监测提供了新的治疗策略，为伤口修复提供了量身定制的选择。MXene作为一种二维功能可调材料，在促进细胞生长、血管生成、募集免疫细胞、避免感染、生物信号传递等方面具有独特的优势和巨大的潜力。本文详细介绍了mxene基材料在组织修复领域的优势，并解决了不同伤口面临的关键挑战，反映了优异的生物活性和组织适应性。值得注意的是，MXene可以作为智能替代设备，实现伤口监测和护理的精确评估。这一发展标志着一个范式的转变，即将进入一个对愈合周期进行无创监测的新时代。然而，利用基于mxene的材料进行再生组织工程的策略面临着一定的挑战和困难，包括确保长期的生物活性功能，开发新的材料类型，以及满足个体临床需求。最后，简要讨论了mxene基材料在伤口处理中的研究方向和技术发展。

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引用次数: 0

Recent advances in electrochemical biosensors for bacterial detection 用于细菌检测的电化学生物传感器研究进展

Nano TransMed

Pub Date : 2025-03-11 DOI: 10.1016/j.ntm.2025.100078

Yunyang Zhou , Qingcui Wang , Ting Xiang , Xiaohua Chen

Accurate and efficient bacterial detection remains a critical challenge in clinical diagnostics and public health. Conventional methods are often constrained by low sensitivity and labor-intensive workflows. In contrast, electrochemical sensors offer distinct advantages: high sensitivity, rapid response, cost-effectiveness, and ease of use. The advancement of electrochemical sensors for bacterial detection relies on the continuous optimization of fundamental sensing architectures and the integration of advanced technologies. This review adopts a dual foundation-to-frontier framework. Analyzing essential sensor components such as functional nanomaterials for interface engineering, precisely engineered biorecognition elements, and established electrochemical detection methodologies. Simultaneously, through an advanced technological lens, we explore cutting-edge interdisciplinary innovations such as dual-modal sensing systems, flexible sensor architectures, and artificial intelligence-driven analytical systems. By synthesizing foundational principles and technological innovations, this review not only informs rational sensor design but also delineates the transition toward miniaturized, intelligent, and high-throughput systems for precision medicine and environmental monitoring. This work aims to offer forward-looking guidance for the future development of bacterial detection technologies.

准确和高效的细菌检测仍然是临床诊断和公共卫生的一个关键挑战。传统的方法往往受到低灵敏度和劳动密集型工作流程的限制。相比之下，电化学传感器具有明显的优势：高灵敏度，快速响应，成本效益和易于使用。电化学细菌检测传感器的发展依赖于基本传感结构的不断优化和先进技术的集成。本综述采用基础到前沿的双重框架。分析必要的传感器组件，如用于界面工程的功能纳米材料，精确工程的生物识别元件，以及建立的电化学检测方法。同时，通过先进的技术镜头，我们探索前沿的跨学科创新，如双模态传感系统，柔性传感器架构和人工智能驱动的分析系统。通过综合基本原理和技术创新，本综述不仅为合理的传感器设计提供了信息，而且描述了向精密医疗和环境监测的小型化，智能化和高通量系统的过渡。本工作旨在为细菌检测技术的未来发展提供前瞻性指导。

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引用次数: 0

The delivery and transmembrane transport mechanism of SVCV nanovaccine SVCV纳米疫苗的传递和跨膜转运机制

Nano TransMed

Pub Date : 2025-03-03 DOI: 10.1016/j.ntm.2025.100077

Han Zhang , Pan-pan Zhang , Xin-Xin Liu , Hai-hua Peng , Qun Liu , Jun Wang , Bin Zhu , Yong-Can Zhou , Yun Sun , Chen Zhang

Spring viremia of carp virus (SVCV) is a fatal microorganism for a variety of cyprinid fish species, sparking off enormous economic losses in freshwater fish aquaculture. For alleviating losses, immersion vaccination is an extremely promising maneuver to prevent and curb on SVCV infection. In our previous research, we designed a modular immersion nanovaccine (LSG-TDH) targeting SVCV, and found that it could induce not merely mucosal immunity but systemic immune responses in zebrafish. Nevertheless, our previous research was unable to elaborate on how LSG-TDH were taken up by the cells. Thereby, this study aimed to investigate its transmembrane transport mechanism in vitro using epithelioma papulosum cyprini (EPC) cells and macrophages as models. The transmembrane transport mechanism of LSG-TDH on EPC cells and macrophages was analyzed by cell fluorescence, flow cytometry and chemical inhibitor experiments. The results showed that the entry of LSG-TDH into cells was time-dependent and energy-dependent. Chlorpromazine significantly inhibited the transmembrane transport of LSG-TDH. The contents of LSG-TDH into EPC cells and macrophages after treated with chlorpromazine decreased by 80 % and 71 %, respectively. It is indicated that the transmembrane transport of LSG-TDH was mainly achieved through clathrin-mediated endocytosis pathway. This study provides a reference for the delivery mechanism of aquatic nanovaccine, which has important scientific significance and application prospect.

鲤鱼病毒春季病毒血症（SVCV）是多种鲤科鱼类的致命微生物，在淡水鱼养殖中造成巨大的经济损失。为了减轻损失，浸入式疫苗接种是预防和控制SVCV感染的极有希望的方法。在我们之前的研究中，我们设计了一种针对SVCV的模块化浸泡纳米疫苗（LSG-TDH），发现它不仅可以诱导斑马鱼的粘膜免疫，还可以诱导全身免疫反应。然而，我们之前的研究无法详细说明LSG-TDH是如何被细胞吸收的。因此，本研究以cyprini丘疹上皮瘤（EPC）细胞和巨噬细胞为模型，探讨其体外跨膜转运机制。通过细胞荧光、流式细胞术和化学抑制剂实验分析LSG-TDH对EPC细胞和巨噬细胞的跨膜转运机制。结果表明，LSG-TDH进入细胞具有时间依赖性和能量依赖性。氯丙嗪显著抑制LSG-TDH的跨膜转运。氯丙嗪处理后，巨噬细胞和巨噬细胞中LSG-TDH含量分别下降80 %和71 %。提示LSG-TDH的跨膜转运主要通过网格蛋白介导的胞吞途径实现。本研究为水生纳米疫苗的递送机制提供了参考，具有重要的科学意义和应用前景。

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引用次数: 0

Harnessing nanoparticle technology for precision medicine in head and neck cancer: Targeted delivery, immunomodulation, and clinical translation 利用纳米颗粒技术进行头颈癌的精准医疗：靶向递送、免疫调节和临床转化

Nano TransMed

Pub Date : 2025-02-21 DOI: 10.1016/j.ntm.2025.100075

Karthikeyan Elumalai , Sivaneswari Srinivasan

Head and neck cancer (HNC) remains a significant challenge in oncology due to poor drug delivery and an immunosuppressive tumour microenvironment (TME). This review focuses on the role of nanoparticles (NPs) in addressing challenges in HNC treatment, highlighting their potential to enhance efficiency and targeting. Researchers are studying different kinds of NPs, like liposomal, polymeric, dendritic, and gold nanoparticles (AuNPs), to see how they can improve drug delivery and change the tumour environment. To improve treatment results, we use specific strategies like targeting receptors, releasing substances inside cells in a controlled way, and adjusting the immune response. The review talks about how NPs focus on cancer-related fibroblasts, stop new blood vessel growth, and tackle problems in moving these treatments into real-world use. These issues include safety, toxicity, being able to produce them on a large scale, and following regulations. Finally, emerging trends, such as hybrid NPs and personalized nanomedicine, are proposed. Nanoparticle technology can greatly change how we treat head and neck cancer. It can improve how drugs are delivered, alter the environment around tumours, and tailor treatments to individual patients, which can make life better for them. This could lead to a new approach in cancer care.in cancer treatment.

头颈癌（HNC）由于药物递送不良和免疫抑制肿瘤微环境（TME），仍然是肿瘤学领域的一个重大挑战。本文综述了纳米颗粒（NPs）在解决HNC治疗挑战中的作用，强调了它们在提高效率和靶向性方面的潜力。研究人员正在研究不同种类的纳米粒子，如脂质体、聚合物、树突状和金纳米粒子（AuNPs），以了解它们如何改善药物输送和改变肿瘤环境。为了提高治疗效果，我们使用了一些特定的策略，如靶向受体，以受控的方式释放细胞内的物质，以及调节免疫反应。这篇综述讨论了NPs如何专注于癌症相关的成纤维细胞，阻止新血管的生长，以及如何解决将这些治疗方法应用于现实世界中的问题。这些问题包括安全性，毒性，能够大规模生产，以及遵守法规。最后，提出了混合纳米粒子和个性化纳米医学等新兴趋势。纳米粒子技术可以极大地改变我们治疗头颈癌的方式。它可以改善药物的输送方式，改变肿瘤周围的环境，并为个体患者量身定制治疗方案，从而改善患者的生活。这可能会导致癌症治疗的新方法。在癌症治疗中。

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引用次数: 0