Nano TransMed最新文献

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Erratum regarding previously published articles 关于以前发表的文章的勘误

Nano TransMed

Pub Date : 2025-01-22 DOI: 10.1016/j.ntm.2025.100072

引用次数: 0

Graphene nanomaterial-based electrochemical biosensors for salivary biomarker detection: A translational approach to oral cancer diagnostics 基于石墨烯纳米材料的唾液生物标志物检测电化学生物传感器：口腔癌诊断的转化方法

Nano TransMed

Pub Date : 2025-01-22 DOI: 10.1016/j.ntm.2025.100073

D. Mahalakshmi , J. Nandhini , G. Meenaloshini , E. Karthikeyan , KK Karthik , J. Sujaritha , Vandhana V , C. Ragavendran

Graphene-based electrochemical biosensors have emerged as promising tools for the early detection and monitoring of oral cancer through salivary biomarker analysis. Graphene's exceptional properties, including high surface area, superior electrical conductivity, and excellent mechanical strength, enable the development of highly sensitive and specific biosensors. This review provides a comprehensive overview of the current state-of-the-art in graphene-based electrochemical biosensors for salivary biomarker detection in oral cancer. We discuss the unique advantages of saliva as a diagnostic medium and highlight the key salivary biomarkers associated with oral cancer, including proteins, DNA, and RNA. Various electrochemical detection techniques, such as cyclic voltammetry, differential pulse voltammetry, electrochemical impedance spectroscopy, field-effect transistors, amperometry, chronoamperometry, and photoelectrochemical methods, are explored in the context of graphene-based biosensors. The challenges associated with the development and clinical translation of these biosensors are also addressed, emphasizing the need for improved functionalization strategies, enhanced stability, and standardized validation protocols. Finally, we present a futuristic outlook on the integration of graphene-based biosensors with artificial intelligence, microfluidics, and telemedicine platforms to enable personalized diagnostics and treatment monitoring. With continued advancements in sensor technology and computational tools, graphene-based electrochemical biosensors have the potential to revolutionize oral cancer management, improving patient outcomes and quality of life.

基于石墨烯的电化学生物传感器已经成为通过唾液生物标志物分析早期检测和监测口腔癌的有前途的工具。石墨烯的特殊性能，包括高表面积，优越的导电性和优异的机械强度，使高灵敏度和特异性生物传感器的发展成为可能。本文综述了目前基于石墨烯的电化学生物传感器用于口腔癌唾液生物标志物检测的最新进展。我们讨论了唾液作为诊断介质的独特优势，并强调了与口腔癌相关的关键唾液生物标志物，包括蛋白质、DNA和RNA。各种电化学检测技术，如循环伏安法、差分脉冲伏安法、电化学阻抗谱、场效应晶体管、安培法、计时安培法和光电化学方法，在石墨烯基生物传感器的背景下进行了探索。与这些生物传感器的开发和临床转化相关的挑战也得到了解决，强调需要改进功能化策略，增强稳定性和标准化验证方案。最后，我们对基于石墨烯的生物传感器与人工智能、微流体和远程医疗平台的集成进行了未来展望，以实现个性化诊断和治疗监测。随着传感器技术和计算工具的不断进步，基于石墨烯的电化学生物传感器有可能彻底改变口腔癌的管理，改善患者的预后和生活质量。

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引用次数: 0

PROTAC-based therapeutics for targeting HPV oncoproteins in head and neck cancers 靶向头颈癌HPV癌蛋白的基于protac的治疗方法

Nano TransMed

Pub Date : 2025-01-16 DOI: 10.1016/j.ntm.2025.100071

Nobendu Mukerjee , Dattatreya Mukherjee

The increasing incidence of Human Papillomavirus (HPV)-related head and neck cancers, particularly oropharyngeal squamous cell carcinomas, highlights the need for advanced therapeutic options beyond the traditional modalities of surgery, radiation, and chemotherapy, which often lead to significant morbidity and lack specificity in targeting the molecular pathogenesis of the disease. Proteolysis Targeting Chimeras (PROTACs) present a novel therapeutic strategy, leveraging the ubiquitin-proteasome system to specifically degrade the oncogenic HPV proteins E6 and E7. This targeted approach not only potentially reduces the side effects associated with conventional treatments but also directly interrupts the cancer-promoting activities of these proteins, offering a promising avenue for more effective and less invasive treatment of HPV-associated malignancies.

人类乳头状瘤病毒（HPV）相关头颈部癌症，特别是口咽鳞状细胞癌的发病率不断上升，突出表明需要在手术、放疗和化疗等传统模式之外的先进治疗选择，这些模式往往导致显著的发病率，并且缺乏针对该疾病分子发病机制的特异性。蛋白水解靶向嵌合体（PROTACs）提出了一种新的治疗策略，利用泛素-蛋白酶体系统特异性降解致癌的HPV蛋白E6和E7。这种有针对性的方法不仅潜在地减少了与传统治疗相关的副作用，而且还直接中断了这些蛋白质的促癌活性，为更有效、侵入性更小的hpv相关恶性肿瘤治疗提供了一条有希望的途径。

引用次数: 0

Antioxidant and anti-diabetic potential of the green synthesized silver nanoparticles using Martynia annua L. root extract 黄花martyna L.根提取物绿色合成纳米银的抗氧化和抗糖尿病潜力

Nano TransMed

Pub Date : 2025-01-09 DOI: 10.1016/j.ntm.2025.100070

Megha B. Abbigeri , Bothe Thokchom , Sapam Riches Singh , Santosh Mallikarjun Bhavi , B.P. Harini , Ramesh Babu Yarajarla

The weed Martynia annua traditionally known as Kakanasika is annual herbaceous plant known for its multiple medicinal properties such as anthelmintic, analgesic, antipyretic, antibacterial, anti-convulsant, anti-fertility, antinociceptive, antioxidant, CNS depressant and wound healing activity. The aqueous root extract of M. annua was subjected to qualitative analysis, revealing the presence of terpeniods, indicative of its rich phytochemicals composition. Utilizing a green synthesis approach, silver nanoparticles (AgNPs) were successfully synthesized from the plant extract. Characterization through UV-Visible spectroscopy, FTIR, DLS, and SEM/EDX confirmed the formation of AgNPs with polygonal morphology and an average size of 64 nm, with the PDI of 0.385. Additionally, the AgNPs demonstrated moderate stability, evidenced by a zeta potential of −21.6 mV. Evaluation of the synthesized AgNPs focused on their anti-diabetic potential. The green synthesized R-AgNPs were potent antioxidant agents. They exhibited significant inhibition of alpha amylase, a pivotal enzyme in carbohydrate metabolism, suggesting their efficacy as anti-diabetic agents. Moreover, the AgNPs enhanced glucose uptake by yeast cells, indicating their promising therapeutic role in managing diabetes mellitus. This study highlights the pharmacological importance of M.annua, particularly its aqueous root extract, in the eco-friendly synthesis of AgNPs with potential therapeutic implications. Further investigation into the mechanism of action and clinical efficacy of these AgNPs in diabetes management is warranted.

传统上被称为Kakanasika的杂草是一年生草本植物，以其多种药用特性而闻名，如驱虫药、镇痛药、解热药、抗菌药、抗惊厥药、抗生育药、抗痛觉药、抗氧化剂、中枢神经系统抑制剂和伤口愈合活性。对黄花楸根水提物进行定性分析，发现黄花楸根水提物中含有萜类化合物，表明黄花楸根水提物具有丰富的植物化学成分。利用绿色合成方法，成功地从植物提取物中合成了纳米银。通过紫外-可见光谱、FTIR、DLS和SEM/EDX表征，证实形成的AgNPs形貌为多边形，平均尺寸为64 nm， PDI为0.385。此外，AgNPs表现出中等的稳定性，zeta电位为- 21.6 mV。评价合成的AgNPs的抗糖尿病潜能。绿色合成的R-AgNPs是有效的抗氧化剂。它们表现出显著的α淀粉酶抑制作用，α淀粉酶是碳水化合物代谢的关键酶，表明它们具有抗糖尿病药物的功效。此外，AgNPs增强了酵母细胞对葡萄糖的摄取，表明它们在控制糖尿病方面有很好的治疗作用。本研究强调了金盏花的药理重要性，特别是其水根提取物，在生态友好的AgNPs合成中具有潜在的治疗意义。进一步研究这些AgNPs在糖尿病治疗中的作用机制和临床疗效是有必要的。

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