Nano TransMed最新文献

{"title":"Curcumin poly D-L lactide nanoparticles demonstrate superior antiplasmodial Efficacy and multi-target binding compared with dihydroartemisinin: Integrative in vivo and in silico analyses","authors":"Olorunfemi Abraham Eseyin ,&nbsp;Aniekan Stephen Ebong ,&nbsp;Ekarika Clement Johnson ,&nbsp;Emmanuel Olorunsola ,&nbsp;Imaobong Etti ,&nbsp;Grace Essien ,&nbsp;Johnny Imoh ,&nbsp;Ekaete Akpabio ,&nbsp;Emmanuel I. Etim ,&nbsp;Grace Effiong ,&nbsp;Sheryar Afzal","doi":"10.1016/j.ntm.2025.100112","DOIUrl":"10.1016/j.ntm.2025.100112","url":null,"abstract":"<div><h3>Background</h3><div>The urgent rise of drug-resistant malaria underscores the need for innovative antimalarial agents with multi-targeting capabilities. Curcumin, a polyphenolic compound derived from turmeric, is known for its extensive pharmacological properties; however, its low bioavailability hinders its clinical application. This study compared the antiplasmodial activity, safety profile, and multitarget binding potential of curcumin and its nanoparticle formulations with those of dihydroartemisinin (DHA).</div></div><div><h3>Methods</h3><div>Curcumin nanoparticles were produced using a modified emulsion-solvent evaporation technique and were characterized through Fourier-transform infrared spectroscopy (FTIR) and dynamic light scattering methods. Acute oral toxicity assessments were conducted in mice following the OECD Guideline 423. Swiss albino mice infected with <em>P. berghei</em> NK-65 were treated with varying doses of curcumin, nanocurcumin, DHA, or distilled water. The parasitemia level was evaluated using Giemsa-stained blood smears. Additionally, molecular docking studies were conducted using AutoDock Vina to target key proteins of <em>P. falciparum</em>, with the visualisation of protein-ligand interactions carried out in Discovery Studio.</div></div><div><h3>Results</h3><div>Both curcumin and nanocurcumin exhibited a dose-dependent increase in parasite clearance, significantly surpassing DHA. Notably, nanocurcumin at lower doses achieved over 90 % reduction in parasitemia. Acute toxicity evaluation indicated no fatalities or severe adverse effects at doses up to 5000 mg/kg. Curcumin exhibited superior binding affinities and more comprehensive interactions with various parasite targets compared with DHA.</div></div><div><h3>Conclusion</h3><div>Curcumin, especially in its nanoparticle form, displays potent multi-target antiplasmodial activity and a favourable safety profile in mice, outperforming DHA. These findings advocate for the continued development of curcumin-based therapeutic strategies for malaria, particularly against strains exhibiting drug resistance.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"5 ","pages":"Article 100112"},"PeriodicalIF":0.0,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic activity of photoactivated curcumin-derived nanocomplexes in combination with antibiotics against planktonic and biofilm bacterial cells","authors":"Humberto Antonio Salazar-Sesatty ,&nbsp;Edeer Iván Montoya-Hinojosa ,&nbsp;Luis D. Terrazas-Armendariz ,&nbsp;Cynthia A. Alvizo-Baez ,&nbsp;Daniel Salas-Treviño ,&nbsp;Paola Bocanegra-Ibarias ,&nbsp;Adrián Camacho-Ortiz ,&nbsp;Itza E. Luna-Cruz ,&nbsp;Juan M. Alcocer-González ,&nbsp;Samantha Flores-Treviño","doi":"10.1016/j.ntm.2025.100110","DOIUrl":"10.1016/j.ntm.2025.100110","url":null,"abstract":"<div><h3>Background</h3><div>Alternative antimicrobial strategies such as antimicrobial photodynamic therapy (aPDT) and curcumin-derived nanocomplexes were assessed in this study against biofilm cells of Gram-positive and Gram-negative clinical isolates.</div></div><div><h3>Methods</h3><div>Curcumin-derived nanocomplexes (curcumin-chitosan magnetic nanoparticles [Cur-Chi-MNPs], carbon magnetic-nanoparticles [Cur-C-MNPs] and Curcumin-derived carbon quantum dots [Cur-QDs] were synthetized and characterized using scanning electron microscopy, transmission electron microscopy, atomic force microscopy, and dynamic light scattering. The antimicrobial activity of photoactivated curcumin-derived nanocomplexes after blue light (400 −470 nm), green light (495 −570 nm), and red light (620 −750 nm) exposure was assessed on biofilm bacterial cells of clinical isolates of Gram-negative and Gram-positive bacteria.</div></div><div><h3>Results</h3><div>Photoactivation of curcumin by green, red light and blue light increased the antibiofilm activity against Gram-positive isolates and Gram-negative isolates, but the effect was higher in Gram-positive pathogens. Green light photoactivation of Cur-Chi-MNPs and Cur-QDs yielded antibiofilm activity against <em>Staphylococcus lugdunensis</em>, whilst Cur-C-MNPs showed antibiofilm activity only against <em>Stenotrophomonas maltophilia</em> regardless of photoactivation.</div></div><div><h3>Conclusions</h3><div>Photoactivated curcumin-derived nanocomplexes showed antimicrobial and antibiofilm properties against some Gram-positive and Gram-negative bacterial strains. Nanocurcumin-mediated aPDT could be a potential treatment option for biofilm eradication of clinical drug-resistant infections.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"5 ","pages":"Article 100110"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SNEDDS delivery of black sticky rice extract: Hepatoprotective and antioxidant potential","authors":"Anggun Hari Kusumawati ,&nbsp;Elfahmi Elfahmi ,&nbsp;Afrillia Nuryanti Garmana ,&nbsp;Rachmat Mauludin","doi":"10.1016/j.ntm.2025.100111","DOIUrl":"10.1016/j.ntm.2025.100111","url":null,"abstract":"<div><div>Black sticky rice (<em>Oryza sativa</em> var. <em>glutinosa</em> Blanco) Extract (BSRE) contains a high concentration of polyphenols, flavonoids, and anthocyanins with known antioxidant and hepatoprotective effects. Nevertheless, its clinical application is limited by poor water solubility and low bioavailability. This study is intended to develop and evaluate self-nanoemulsifying drug delivery systems (SNEDDS) and solid self-nanoemulsifying drug delivery systems (S-SNEDDS) formulations of BSRE to enhance its antioxidant and hepatoprotective effects. The systems are characterized for their physicochemical properties and evaluated <em>in vitro</em> and <em>in vivo</em> in carbon tetrachloride (CCl₄)-induced liver damage in rats. Ethanolic maceration extraction was performed, followed by phytochemical and ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS)/MS fingerprinting. SNEDDS was formulated with corn oil, Tween 80, and propylene glycol and optimized through pseudo-ternary phase diagrams. The optimized system was then adsorbed onto Neusilin® US2 to produce S-SNEDDS. Both systems were characterized for droplet size, emulsification time, zeta potential, and thermodynamic stability. Dissolution and antioxidant activity (DPPH assay) were measured <em>in vitro</em>, while <em>in vivo</em> efficacy was tested in the CCl₄-induced hepatotoxicity rat model. BSRE was found to have high cyanidin-3-O-glucoside (13.87 ± 0.12 mg/g) and quercetin (24.10 ± 1.34 mg/g) content. SNEDDS produced nano-sized droplets (∼15 nm) with fast emulsification and enhanced solubility at pH 1.2, 4.5, and 6.8. Antioxidant activity was markedly improved in SNEDDS-BSRE (IC₅₀: 32.6 µg/mL) compared to crude BSRE (IC₅₀: 47.4 µg/mL). SNEDDS-BSRE at 100 and 200 mg/kg body weight (BW) significantly lowered serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transferase (GGT), alkaline phosphatase (ALP), and bilirubin (BIL) and normalized albumin (ALB) level. Histopathological analysis confirmed reduced hepatic necrosis and inflammation. This investigation illustrates that SNEDDS-based delivery system profoundly improves the physicochemical stability, antioxidant activity, and hepatoprotective effect of BSRE, favoring its development as a functional nutraceutical. Additional pharmacokinetic and clinical studies are necessary to establish its translational feasibility.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"5 ","pages":"Article 100111"},"PeriodicalIF":0.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145927007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Next-generation injectable hydrogels: Advanced crosslinking strategies, multi-stimuli responsiveness, and translational advances for precision regenerative medicine","authors":"Govindaraj Sabarees,&nbsp;Yobu Sam Jebaraj,&nbsp;Elumalai Ezhilarasan,&nbsp;Yuvaraj Dravid Ragul","doi":"10.1016/j.ntm.2025.100109","DOIUrl":"10.1016/j.ntm.2025.100109","url":null,"abstract":"<div><div>Injectable hydrogels represent a transformative platform in biomaterials, enabling minimally invasive delivery and precise therapeutic localization with biomimetic structural and functional properties. Recent innovations in chemistry and crosslinking ranging from photopolymerization, click chemistry, and Schiff’s base formation to enzyme-mediated catalysis and supramolecular assemblies allow finely tuned gelation kinetics, mechanical strength, degradation, and responsive bioactivity under physiological conditions. This comprehensive review systematically examines next-generation injectable hydrogels, highlighting chemical and physical crosslinking mechanisms and integration of multi-stimuli responsiveness including temperature, pH, light, and enzymatic triggers to achieve spatiotemporal control of tissue regeneration and drug delivery. We critically evaluate translational advances across diverse tissue engineering domains such as bone, cartilage, cardiac, neural, skin, liver, pancreas, vascular, and periodontal tissues. Challenges in scalability, reproducibility, sterilization, and regulatory approval remain, yet ongoing progress in biofunctionalization and injectable biofabrication underpins their promise for personalized regenerative medicine. Bridging fundamental materials science and clinical translation, injectable hydrogels are poised to revolutionize minimally invasive therapies and precision medicine in the decade ahead.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"5 ","pages":"Article 100109"},"PeriodicalIF":0.0,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145884977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Platelet lysate promotes proliferation and angiogenic activity of dental pulp stem cells via store-operated Ca2+ entry” [Nano TransMed 2 (2023) 100021]","authors":"Xiangyan Liao ,&nbsp;Min Chen ,&nbsp;Yuan Zhang ,&nbsp;Shengcun Li ,&nbsp;Yejian Li ,&nbsp;Yan He ,&nbsp;Yanteng Zhao ,&nbsp;Lihua Luo","doi":"10.1016/j.ntm.2025.100094","DOIUrl":"10.1016/j.ntm.2025.100094","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100094"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTED: Abutilon indicum-mediated green synthesis of NiO and ZnO nanoparticles: Spectral profiling and anticancer potential against human cervical cancer for public health progression [Nano TransMed 3C (2024) 100049]","authors":"Vinotha Mani ,&nbsp;Keerthana Shrri Gopinath ,&nbsp;Nithya Varadharaju ,&nbsp;Dapkupar Wankhar ,&nbsp;Arjunan Annavi","doi":"10.1016/j.ntm.2025.100098","DOIUrl":"10.1016/j.ntm.2025.100098","url":null,"abstract":"","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100098"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrospun based functional scaffolds for biomedical engineering: A review","authors":"Laldinthari Suamte,&nbsp;Punuri Jayasekhar Babu","doi":"10.1016/j.ntm.2024.100055","DOIUrl":"10.1016/j.ntm.2024.100055","url":null,"abstract":"<div><div>Tissue engineering (TE) has made significant strides and progress in the development of functional biomaterials. Among different techniques that has been adopted, electrospinning is a versatile and widely adopted fabrication process for creating biomedical scaffolds. These intricate 3-dimensional matrices play a crucial role in various tissue engineering applications. Electrospinning is a technique commonly utilized in TE as it produces ultrafine fibres through an electric field to draw polymer solutions, melting them into thin fibres. These fibres form a scaffold with a high surface area-to-volume ratio, making them ideal for tissue engineering. This review discusses the various biomedical applications of electrospun scaffolds in different fields, such as dentistry, bone regeneration, wound healing, bone marrow regeneration, vascular tissue engineering, corneal regeneration and liver tissue engineering. Also, this review highlights the multiple parameters affecting the design of the scaffolds for tissue regeneration. As research in this field continues, electrospun scaffolds are likely to become more reliable and effective. Their ability to mimic natural tissue structures and promote cellular interactions positions them as a promising avenue for future biomedical advancements.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100055"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A mini-review on the multimodal applications of engineered magnetic nanoparticles in diagnosis and therapy","authors":"Jagabandhu Bag ,&nbsp;Rudradeep Hazra ,&nbsp;Rupam Mahish ,&nbsp;Avijit Kumar Dey ,&nbsp;Dishani Sukul ,&nbsp;Ashok Kumar S K ,&nbsp;Sourav De","doi":"10.1016/j.ntm.2025.100100","DOIUrl":"10.1016/j.ntm.2025.100100","url":null,"abstract":"<div><div>The magnetic nanoparticles (MNPs) have emerged as multifunctional tools in recent medicine by virtue of their tunable size, larger surface area, and characteristic magnetic properties. Engineered MNPs have been well investigated in the recent two decades for diagnostic imaging, targeted drug delivery, hyperthermia, and multifunctional therapeutic applications. Their efficacy is profoundly dependent on controlled synthesis, surface functionalization, and biocompatibility, significantly influencing stability, biodistribution, and clinical efficacy. Recent work demonstrates their potential for imaging sensitivity enhancement, precise drug targeting, and therapeutic efficacy improvement through multifunctional integration of diagnostic and therapeutic functions. Despite aggregation, toxicity, and scalability challenges, continuous innovation in synthesis methodology and surface engineering is enhancing their translational potential. This review provides current developments in the design and biomedical applications of engineered MNPs, which emphasize their value in promoting personalized medicine and theranostics. Ultimately, MNPs are a revolutionary platform that integrates diagnosis and therapy, opening up new avenues toward effective and minimally invasive patient care.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"5 ","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of graphene quantum dots with 3D scaffolds for precision medicine and regenerative applications","authors":"Yuvaraj Muthu,&nbsp;Meenaloshini Gopalakrishnan,&nbsp;Prabakaran Sankar,&nbsp;Elizabeth Rani Edwin,&nbsp;Karthikeyan Elumalai","doi":"10.1016/j.ntm.2025.100095","DOIUrl":"10.1016/j.ntm.2025.100095","url":null,"abstract":"<div><div>Integrated onto three-dimensional (3D) scaffolds, graphene quantum dots (GQDs) present a novel method for tissue creation and precision drug delivery. Among its special characteristics are photoluminescence, biocompatibility, and a large surface area fit for functionalizing. Targeting drug delivery, tissue regeneration, and diagnostic capability, GQD-functionalized 3D scaffolds provide. This review discusses the synthesis, characteristics, and functionalizing techniques of GQD-functionalized 3D scaffolds to achieve desired delivery. GQD-functionalized 3D scaffolds underscore their possible use by means of synergistic effects in cancer treatment, tissue engineering, wound healing, and chronic illness management. Even with real-time medication release and therapeutic effect monitoring allowed, GQD-functionalized 3D scaffolds can provide chemotherapeutic drugs, nucleic acids, and proteins to tumor locations. In tissue engineering, GQD-functionalized scaffolds help cells in proliferation, differentiation, and neovascularization. Moreover, GQD-functionalized 3D scaffolds speed wound healing and help avoid infections. GQD-functionalized 3D scaffolds indicate a promising method for continuous medicine administration and tissue regeneration for chronic diseases, including diabetes, cardiovascular diseases, and neurodegenerative diseases. Still, there are somewhat typical issues with long-term safety, mass production, and regulatory approval. Green synthesis methods, better functionalizing methods, and design-based stimuli-responsive scaffolds are among the future directions. Clinical application of this technology depends totally on cooperative efforts of material scientists, biomedical engineers, medical practitioners, and regulatory authorities. Depending on continuous development, GQD-functionalized 3D scaffold technology presents enormous possibilities to transform medicine delivery and regeneration.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The anticancer, antioxidant, and antimicrobial properties of zinc oxide nanoparticles: A comprehensive review","authors":"Aeshah M. Mohammed ,&nbsp;Mohammed Mohammed ,&nbsp;Jawad K. Oleiwi ,&nbsp;Falah H. Ihmedee ,&nbsp;Tijjani Adam ,&nbsp;Bashir O. Betar ,&nbsp;Subash C.B. Gopinath","doi":"10.1016/j.ntm.2025.100097","DOIUrl":"10.1016/j.ntm.2025.100097","url":null,"abstract":"<div><div>This review provides a comprehensive analysis of Zinc Oxide Nanoparticles (ZnO NPs) in biomedical applications, focusing on their anticancer, antioxidant, and antimicrobial properties. ZnO NPs, distinguished by their unique physicochemical attributes, are increasingly recognized in nanomedicine for their potential in cancer therapy, oxidative stress management, and infection control. The synthesis and characterization of ZnO NPs, crucial for their functionality and safety, are discussed, emphasizing the impact of particle size, morphology, and purity. ZnO NPs exhibit promising capabilities in oncology through reactive oxygen species generation, apoptosis induction, and anti-proliferative effects. Their efficacy against diverse cancer types and insights from emerging clinical trials are evaluated. The review also highlights the antioxidant properties of ZnO NPs, comparing their effectiveness with conventional antioxidants and their role in combating oxidative stress-related diseases, supported by case studies. The antimicrobial potential of ZnO NPs is explored through their interaction with microbial cell structures and the generation of reactive oxygen species, demonstrating their broad-spectrum efficacy against bacteria, fungi, and viruses. Applications in healthcare and infection control are discussed. Furthermore, the review addresses biocompatibility and toxicity concerns, covering in vitro and in vivo studies, factors influencing toxicity, and regulatory perspectives. Challenges in clinical applications, including delivery systems and translational research obstacles, are examined. Finally, the review outlines future prospects, such as emerging research trends, potential in combined therapies, and advancements in nanotechnology, concluding with the pivotal role of ZnO NPs in advancing therapeutic solutions and their promising future in healthcare.</div></div>","PeriodicalId":100941,"journal":{"name":"Nano TransMed","volume":"4 ","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}