Pub Date : 2000-08-01DOI: 10.1016/S1164-6756(00)90081-1
Sociétéfrançaise de dermatologie (SFD), Sociétéde pathologie infectieuse de langue française (SPILF)
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Pub Date : 2000-07-01DOI: 10.1016/S1164-6756(00)80008-0
P.M. Honoré , J. Jamez , M. Wauthier , B. Pirenne , J.P. Pelgrim , T. Dugernier
—
Introduction
—
Enjeux
•
Cibles: cascade inflammatoire
•
Cibles: voies de la dépression myocardique
•
Le concept de clairance effective
•
Modèles animaux expérimentaux
•
Études humaines rétrospectives et prospectives
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Relation entre les effets cliniques et l’extraction de médiateurs
—
Optimalisation de l’hémofiltration pour favoriser l’extraction desmédiateurs
—
Mise en œuvre, indications actuelles et risques potentiels
—
Raisons d’être des futures études
—
Conclusions
—
Introduction
—
Potential issues
•
Targeting the inflammatory cascade:
-
removal by filtration
-
removal by adsorption
•
Targeting the myocardial depressant pathway:
-
removal by filtration
-
removal by adsorption
—
The concept of additional clearance
—
Animal experimental models
—
Human retrospective and prospective studies
—
Importance of the timing of the procedure
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Optimization of hemofiltration for enhancing mediator removal
—
Implementation, current indications and potential harmful effects
—
Rationale for future trials
—
Conclusions
•目标:炎症级联•目标:心肌抑制途径•有效清除的概念•实验动物模型•回顾性和前瞻性人类研究-临床效果与介质提取之间的关系-优化血滤以促进介质提取-实施,指导当前和未来的潜在风险存在的理由—研究———介绍潜在结论(美国•调查the inflammatory瀑布:-removal by filtration-removal by the myocardial吸附美国•调查depressant路径:-removal by filtration-removal by吸附—附加清除—动物实验模型的概念》—Human回顾与前瞻研究—圣母圣母—优化程序的时机非常of hemofiltration for提升mediator消除-实施、当前适应症和潜在有害影响-未来试验的理由-结论
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Pub Date : 2000-07-01DOI: 10.1016/S1164-6756(00)80004-3
H. Gastinne , C. Raffy , V. Richard , A. Vergnenègre , A. Desachy , B. François , R.F. Gobeaux , P. Vignon
Aim: The aim of this study was to determine the real cost of a patient's stay in an intensive care unit (ICU), to analyze the variance within 16 new specific diagnosis related groups (DRG) proposed by the Société de Réanimation de Langue Française, and thereby to assess the relevance of this classification.
Method: Real costs were determined daily and on a duration of stay basis for each DRG using a computerized clinical information system (CarevueTM, Hewlett Packard) and customized software. The prospect cost assessment was made after two data processing steps: conversion of flowsheet data into 15 cost-category units, and multiplication of the number of cost-category units by set unit price.The validity of the calculated costs was assessed by comparing them with actual ICU costs obtained from the administration.
Study setting: This study was carried out in a general ICU with 22 beds in a teaching hospital with a total of 1,398 short-stay beds.
Patients: This prospective study was based on hospital admissions over a 1-year period, i.e., consecutive hospitalizations between January 1st and December 31st.
Results: An analysis was.made of 859 ICU stays, corresponding to 7,142 days of hospitalization. The results were as follows: mean SAPS II: 40.9 ± 18, overall ICU mortality: 25%. During the study period, the total calculated costs per patient accounted for 93.4% of the ICU expenditure allocated by the administration. For each DRG in the ICU, within-group homogeneity was observed, and the coefficient of variationfor costs (SD/mean value) was consistently less than 1. The 16 DRG explained 60.4% of the cost variance. SAPS II had ho influence on total cost prediction.
Conclusions: This analysis confirms the reliability of the results that have already been obtained in another: study, The cost analysis homogeneity obtained bythis classification was superior to that of the majority of medical DRGs. In this study, the SAPS II did not play a significant role in predicting the cost of the hospital stay.
Buts de l’étude: Mesurer le coût réel des séjours en réanimation et analyser leur variance à l’intérieur des 16 nouveaux groupes homogènes de malade (GHM) proposés par la Société de réanimation de langue française, afin d’évaluer la pertinence de cette classification.
Protocole: L’évaluation prospective des coûts a été réalisée à partir des données d’un dossier de soins informatisé (CarevueTM, Hewlett Packard), à l’aide d’un logiciel spécifique, après deux étapes de traitement de l’information: conversion des données en 15 unités d’œuvre, multiplication du nombre d’unités d’œuvre par leur prix unitaire au tarif de l’établissement. La validité des coûts a été évaluée par rapport à la comptabilité analytique de l’hôpital. Les coûts ont été calcu
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Pub Date : 2000-07-01DOI: 10.1016/S1164-6756(00)80010-9
A. Campion, R. Cremer, S. Leteurtre, C. Fourier, F. Leclerc
In children, community-acquired staphylococcal pneumonia due to Staphylococcus aureus is an uncommon but potentially severe disease, in particular when S. aureus produces toxins. In this study, we report the case of a 14-year old girl without a record of previous illness, in whom Pantin-Valentine leucocidin may have been involved In the fatal outcome. In spite of treatment, the outcome was negative. The patient presented with respiratory failure, and developed septic shock with disseminated intravascular coagulation followed by prolonged coma and death after six days of intensive care (tenth day of illness). In the case of staphylococcal pneumonia with ieucopenia, the presence of the Pantin-Valentine leucocidin and other toxins should be investigated in an attempt to determine their precise pathogenic roles.
Les pneumopathies staphylococciques communautaires de l’enfant sont rares, mais elles peuvent être sévères, notamment lorsque le staphylocoque doré produit des toxines. Nous en décrivons une observation chez une fille de 14 ans, sans antécédent, dans laquelle le rôle de la leucocidine de Ranton-Valentine est évoqué. L’évolution a été; défavorable, conduisant au décès au sixième jour du séjour en réanimation (dixième jourde la maladie) dans un tableau d'insuffisance respiratoire, de choc septique avec coagulation intravascular disséminée, puis de coma dépassé. En cas de Pneumopathie staphylococcique avec leucopénie, la leucocidine de Panton-Valentine et les autres toxines devraient être recherchées; afin de préciser leurs rôles pathogéniques.
在儿童中,由金黄色葡萄球菌引起的社区获得性葡萄球菌肺炎是一种罕见但潜在严重的疾病,特别是当金黄色葡萄球菌产生毒素时。在这项研究中,我们报告了一名14岁女孩的病例,她以前没有疾病记录,其中潘汀-瓦伦丁白细胞灭活素可能参与了致命的结果。尽管进行了治疗,但结果是消极的。患者在重症监护6天后(发病第10天)出现呼吸衰竭,并发感染性休克并弥漫性血管内凝血,随后出现长时间昏迷和死亡。在葡萄球菌性肺炎伴白细胞减少的情况下,应调查patin - valentine白细胞杀素和其他毒素的存在,以试图确定其确切的致病作用。Les pneumopathies staphylococciques communatres de l 'enfant sonrares, mais elles peuvent être ssamuires,注:Les staphylocoque dorsproduct des toxines。没有一个人能观察到其他的人,没有一个人能观察到其他的人,没有一个人能观察到其他的人,没有一个人能观察到其他的人,也没有一个人能观察到其他的人。L '日新月异;danci.99cha.com (danci.9cha.com)、danci.9cha.com (danci.9cha.com)、danci.9cha.com (danci.9cha.com)、danci.9cha.com (danci.9cha.com)、danci.9cha.com (danci.9cha.com)、danci.9cha.com (danci.9cha.com)、danci.9cha.com (danci.9cha.com)。En cas de Pneumopathie staphylococcique avec leucopsamine, la leucocidine de Panton-Valentine et les res toxines变种être recherchsames;Afin de pracciiser leurs rôles pathogsamniques。
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Pub Date : 2000-07-01DOI: 10.1016/S1164-6756(00)80009-2
Y. Loubières, A. Rabiller, A. Vieillard-Baron, J.M. Schmitt, F. Jardin
In this study, the case was reported of a 60-year-old male with a chronic respiratory disorder following a poliomyelitic infection. He was treated by a SAMU team (Glasgow score=4) for a comatose state, and no sign of localization of disease or meningitis was found. Given the preliminary diagnostic findings, mechanical ventilation was instigated; and several minutes later generalized seizures were observed which did not respond to 10 mg diazepam, but which continued when the subject was admitted to the emergency ward, The following day, the patient appeared to have regained normal function and consciousness. It was concluded that these seizures were due to a rapid acidemia-alcalemia shift in a person with a preexisting chronic respiratory disorder.
Nous rapportons le cas d’un malade insuffisant respiratoire chronique qui a convulsé à deux reprises lors de la correction rapide d’une hypercapnie à la mise en route d’une ventilation artificielle. Le facteur déclenchant de ces convulsions semble être une alcalémie dont les conséquences sont discutées. Cette complication potentielle incite à ne pas corriger trop rapidement une hypercapnie au cours des premières heures de ventilation artificielle chez l’insuffisant respiratoire décompensé.
{"title":"Convulsions de reventilation","authors":"Y. Loubières, A. Rabiller, A. Vieillard-Baron, J.M. Schmitt, F. Jardin","doi":"10.1016/S1164-6756(00)80009-2","DOIUrl":"10.1016/S1164-6756(00)80009-2","url":null,"abstract":"<div><p>In this study, the case was reported of a 60-year-old male with a chronic respiratory disorder following a poliomyelitic infection. He was treated by a SAMU team (Glasgow score=4) for a comatose state, and no sign of localization of disease or meningitis was found. Given the preliminary diagnostic findings, mechanical ventilation was instigated; and several minutes later generalized seizures were observed which did not respond to 10 mg diazepam, but which continued when the subject was admitted to the emergency ward, The following day, the patient appeared to have regained normal function and consciousness. It was concluded that these seizures were due to a rapid acidemia-alcalemia shift in a person with a preexisting chronic respiratory disorder.</p></div><div><p>Nous rapportons le cas d’un malade insuffisant respiratoire chronique qui a convulsé à deux reprises lors de la correction rapide d’une hypercapnie à la mise en route d’une ventilation artificielle. Le facteur déclenchant de ces convulsions semble être une alcalémie dont les conséquences sont discutées. Cette complication potentielle incite à ne pas corriger trop rapidement une hypercapnie au cours des premières heures de ventilation artificielle chez l’insuffisant respiratoire décompensé.</p></div>","PeriodicalId":101063,"journal":{"name":"Réanimation Urgences","volume":"9 4","pages":"Pages 298-300"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1164-6756(00)80009-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82606163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-07-01DOI: 10.1016/S1164-6756(00)80003-1
F. Coulomb , L. Moret , M. Boudon , A. Conia , N. Letellier
Although the economic aspect of intensive care units is of considerable importance, it is not sufficiently taken into account in the ‘diagnosis related groups’ (DRG) in the current version of the Programme de Médicalisation des Systèmes d’Information (PMSI). A medico-economic classification based on organ failure in intensive care patients was set up by the following groups: the Société de Réanimation de Langue Française (SRLF), the Société Française d’Anesthésie-Réanimation (SFAR) and Image. In the case of multi-unit hospitalization, most frequently in intensive care units (ICU), the DRG is nevertheless Inaccurately associated with the surgical department, or the unit in which the duration of hospital stay was the longest; and in the case of a similar length of stay in two departments, the last unit takes precedence regarding the DRG. However, the economic requirements of ICUs are real, and constitute 15 to 20% of the hospital budget for less than 5% beds.
Aim: The aim of this study was to apply the current PMSI classification to a retrospective study, i.e., 4,027 consecutive stays (1989–1997) in an 8-bed medico-surgical ICU, and to compare this with the 1993–1994 SRLF database. Method: The data on 3,646 of the 4,027 consecutive stays was divided into 16 groups, as defined by SFAR-SRLF-Image. The parameters for the database were those outlined in the PMSI, gravity index (Simplified Acute Physiologic Score, SAPS, with SAPS I prior to 1996 converted to SAPS II, and with SAPS II after January 1st 1997), omega score, organ failure procedures noted on a dally basis, and diagnostic information based on CIM 9 1989–1995) and CIM 10 (after January 1st 1997), These findings were then compared to those from the SRLF database.
Results: All patients were included in the 16 groups, and a descriptive and a comparative analysis were made of the data. The classification explained 66% of the ICU workload (omega score) and 52% of the duration of stay. Fourteen groups out of 16 had an orrega coefficent of variation of less than 1. The main differences between the retrospective study database and that of the SRLF were the patient distribution within; groups, length of hospital stay and a 30–40% lower omega score for those groups with long duration of hospitalization.
Conclusion: The medico-economic SRLF-SFAR-image classification that has been proposed can be easily applied to the database of a short-stay 400-bed ICU, It is simple to use and aims at providing an economic evaluation of the hospital stay. The differences noted between the two databases could be due to structural and study population recrultment différencés, and should be further reassessed via a prospective multicenter study, including hospitals of different sizes.
Si le poids économique des services de réanimation est réel, il n'est que peu pris en compte dan
虽然重症监护病房的经济方面相当重要,但在当前版本的信息系统管理计划(PMSI)中,“诊断相关组”(DRG)没有充分考虑到这一点。根据重症监护病人器官衰竭的医学-经济分类是由下列团体建立的:法国)社会组织(SRLF)、法国麻醉”(SFAR)和Image。在多单位住院的情况下,最常见的是在重症监护病房(ICU),但DRG与外科或住院时间最长的单位的关联不准确;在两个部门停留时间相似的情况下,最后一个单位优先考虑DRG。然而,icu的经济需求是真实存在的,不到5%的床位却占医院预算的15%至20%。目的:本研究的目的是将目前的PMSI分类应用于一项回顾性研究,即4,027例连续住院(1989-1997)8床内科-外科ICU,并将其与1993-1994年SRLF数据库进行比较。方法:根据SFAR-SRLF-Image的定义,将4027例连续住院患者中的3646例数据分为16组。数据库的参数包括PMSI、重力指数(简化急性生理评分,SAPS, 1996年之前的SAPS I转换为SAPS II, 1997年1月1日之后的SAPS II)、omega评分、每天记录的器官衰竭过程,以及基于CIM 9(1989-1995)和CIM 10(1997年1月1日之后)的诊断信息,然后将这些结果与SRLF数据库中的结果进行比较。结果:所有患者均纳入16组,对资料进行描述性分析和比较分析。该分类解释了66%的ICU工作量(omega评分)和52%的住院时间。16组中有14组的orrega变异系数小于1。回顾性研究数据库与SRLF数据库的主要差异在于患者分布;住院时间较长的组的omega评分低30-40%。结论:所提出的srlf - sfar影像分类方法可方便地应用于400床位ICU短住院期数据库,使用简单,旨在对住院时间进行经济评价。两个数据库之间的差异可能是由于结构和研究人群招募的不同,应通过包括不同规模医院在内的前瞻性多中心研究进一步重新评估。如果将各种各样的薪金和服务分别定为薪金和薪金,那么将不需要在薪金和薪金方面进行比较,也不需要在薪金和薪金方面进行比较。一个分类medico-economique basee苏尔les defaillances内脏suppleees疾病elaboree par la SRLF《SFAR groupe形象》(ENSP)。目的:应用数据分类方法,将不同年龄的成人和青少年的成人和青少年的成人和青少年的成人和青少年的成人和青少年的成人和青少年的成人和青少年的成人进行比较。msamthode: Trois mille six cent quarte - 6 ssamjours exploitables parmi 4027 ssamjours consamcutifes de 1989 / 1997 / ssamjours consamcutifes de 1989 / 1997 / ssamjours resamicpartis共16组。在常规情况下,将Saps I转换为Saps II(1997年以前),将Saps II分类为Saps II, score omacei,将Saps I替换为Saps II,将Saps II替换为Saps II,将Saps II替换为Saps II,将Saps II分类为Saps II,将Saps II分类为Saps II。我不需要ensuite samtest . coms . coms . coms . coms . coms . coms . coms . coms . coms . coms . coms . coms . coms . coms . coms . coms . coms . coms . coms . coms . cn . 1993-1994年32000个samtest . cn . cn)。变性人:变性人是指变性人,变性人是指变性人。分类明确66%的人认为是单纯的samac, 52%的人认为是单纯的samac。四分之一组的变异系数小于16个,其变异系数为1。不同的患者分为不同组,不同的患者分为不同的组,不同的患者分为不同的组,不同的患者分为不同的组,不同的患者分为不同的组,不同的组分为不同的组,不同的组分为不同的组,不同的组分为不同的组,不同的组分为不同的组,不同的组分为不同的组,不同的组分为不同的组。结论:采用简易分类测试方法,可有效地测量不同类型的变性人。不同的交换交换中心有不同的交换交换中心、不同的交换交换中心、不同的交换交换中心、不同的交换交换中心、不同的交换交换中心、不同的交换交换中心、不同的交换交换中心和不同的交换交换中心。i doivent être samtudisamas prospectivedans une samudemulticentrque。
{"title":"La classification médico-économique SRLF-SFAR-Image est applicable à un service de réanimation polyvalente d'un centre hospitalier général","authors":"F. Coulomb , L. Moret , M. Boudon , A. Conia , N. Letellier","doi":"10.1016/S1164-6756(00)80003-1","DOIUrl":"10.1016/S1164-6756(00)80003-1","url":null,"abstract":"<div><p><strong>A</strong>lthough the economic aspect of intensive care units is of considerable importance, it is not sufficiently taken into account in the ‘diagnosis related groups’ (DRG) in the current version of the Programme de Médicalisation des Systèmes d’Information (PMSI). A medico-economic classification based on organ failure in intensive care patients was set up by the following groups: the Société de Réanimation de Langue Française (SRLF), the Société Française d’Anesthésie-Réanimation (SFAR) and Image. In the case of multi-unit hospitalization, most frequently in intensive care units (ICU), the DRG is nevertheless Inaccurately associated with the surgical department, or the unit in which the duration of hospital stay was the longest; and in the case of a similar length of stay in two departments, the last unit takes precedence regarding the DRG. However, the economic requirements of ICUs are real, and constitute 15 to 20% of the hospital budget for less than 5% beds.</p><p><strong>Aim:</strong> The aim of this study was to apply the current PMSI classification to a retrospective study, i.e., 4,027 consecutive stays (1989–1997) in an 8-bed medico-surgical ICU, and to compare this with the 1993–1994 SRLF database. <strong>Method:</strong> The data on 3,646 of the 4,027 consecutive stays was divided into 16 groups, as defined by SFAR-SRLF-Image. The parameters for the database were those outlined in the PMSI, gravity index (Simplified Acute Physiologic Score, SAPS, with SAPS I prior to 1996 converted to SAPS II, and with SAPS II after January 1st 1997), omega score, organ failure procedures noted on a dally basis, and diagnostic information based on CIM 9 1989–1995) and CIM 10 (after January 1st 1997), These findings were then compared to those from the SRLF database.</p><p><strong>Results:</strong> All patients were included in the 16 groups, and a descriptive and a comparative analysis were made of the data. The classification explained 66% of the ICU workload (omega score) and 52% of the duration of stay. Fourteen groups out of 16 had an orrega coefficent of variation of less than 1. The main differences between the retrospective study database and that of the SRLF were the patient distribution within; groups, length of hospital stay and a 30–40% lower omega score for those groups with long duration of hospitalization.</p><p><strong>Conclusion:</strong> The medico-economic SRLF-SFAR-image classification that has been proposed can be easily applied to the database of a short-stay 400-bed ICU, It is simple to use and aims at providing an economic evaluation of the hospital stay. The differences noted between the two databases could be due to structural and study population recrultment différencés, and should be further reassessed via a prospective multicenter study, including hospitals of different sizes.</p></div><div><p><strong>S</strong>i le poids économique des services de réanimation est réel, il n'est que peu pris en compte dan","PeriodicalId":101063,"journal":{"name":"Réanimation Urgences","volume":"9 4","pages":"Pages 241-247"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1164-6756(00)80003-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83443301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2000-07-01DOI: 10.1016/S1164-6756(00)80012-2
F. Joye , F. Marion , M. Orrillard , C. Allais
{"title":"Colite pseudomembraneuse sévère à Clostridium difficile: une complication inhabituelle de la rifampicine","authors":"F. Joye , F. Marion , M. Orrillard , C. Allais","doi":"10.1016/S1164-6756(00)80012-2","DOIUrl":"10.1016/S1164-6756(00)80012-2","url":null,"abstract":"","PeriodicalId":101063,"journal":{"name":"Réanimation Urgences","volume":"9 4","pages":"Pages 311-312"},"PeriodicalIF":0.0,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1164-6756(00)80012-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86306013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}