Pub Date : 2025-10-01DOI: 10.1016/j.rcreue.2025.06.012
Pablo Arango Guerra , Santiago Monsalve Yepes , Andrés Chavarriaga Restrepo , Carlos Jaime Velásquez
Introduction
The association of certain myositis-specific antibodies (MSA) with the development of interstitial lung disease (ILD) in relation to inflammatory myopathies, such as antisynthetase syndrome and anti-MDA5, is well known. However, the potential relationship with the anti-TIF1γ antibody is not well understood, as the reported cases to date are few and have not allowed for solid confirmation of this association. Most of the literature has focused primarily on the association with malignant neoplasms. We aim to include two new cases in the existing literature to support the assertion of the link despite its infrequency.
Objective
To report two cases of ILD associated with anti-TIF1γ positive dermatomyositis (DM).
Materials and methods
A description of the clinical characteristics of two cases of anti-TIF1γ positive DM with ILD and a comparison with analogous cases.
Results
Two cases are described, the first of a 47-year-old man and the second of a 57-year-old woman, both diagnosed with anti-TIF1γ positive DM with the presence of ILD. Underlying malignancy was ruled out due to the presence of the MSA in question, and other potential causes of ILD were excluded, leading to the initiation of immunosuppressive treatment in both cases.
Conclusion
It is essential to further investigate the relationship between inflammatory myopathy and how different MSAs, other than antisynthetase and anti-MDA5 are also associated with ILD. Finding two cases related to anti-TIF1γ and knowing that there are analogous cases generates this hypothesis.
{"title":"Anti-TIF1γ-positive dermatomyositis with interstitial lung involvement: Report of two cases","authors":"Pablo Arango Guerra , Santiago Monsalve Yepes , Andrés Chavarriaga Restrepo , Carlos Jaime Velásquez","doi":"10.1016/j.rcreue.2025.06.012","DOIUrl":"10.1016/j.rcreue.2025.06.012","url":null,"abstract":"<div><h3>Introduction</h3><div>The association of certain myositis-specific antibodies (MSA) with the development of interstitial lung disease (ILD) in relation to inflammatory myopathies, such as antisynthetase syndrome and anti-MDA5, is well known. However, the potential relationship with the anti-TIF1γ antibody is not well understood, as the reported cases to date are few and have not allowed for solid confirmation of this association. Most of the literature has focused primarily on the association with malignant neoplasms. We aim to include two new cases in the existing literature to support the assertion of the link despite its infrequency.</div></div><div><h3>Objective</h3><div>To report two cases of ILD associated with anti-TIF1γ positive dermatomyositis (DM).</div></div><div><h3>Materials and methods</h3><div>A description of the clinical characteristics of two cases of anti-TIF1γ positive DM with ILD and a comparison with analogous cases.</div></div><div><h3>Results</h3><div>Two cases are described, the first of a 47-year-old man and the second of a 57-year-old woman, both diagnosed with anti-TIF1γ positive DM with the presence of ILD. Underlying malignancy was ruled out due to the presence of the MSA in question, and other potential causes of ILD were excluded, leading to the initiation of immunosuppressive treatment in both cases.</div></div><div><h3>Conclusion</h3><div>It is essential to further investigate the relationship between inflammatory myopathy and how different MSAs, other than antisynthetase and anti-MDA5 are also associated with ILD. Finding two cases related to anti-TIF1γ and knowing that there are analogous cases generates this hypothesis.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 409-415"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.rcreue.2025.09.004
Hanene Lassoued Ferjani , Ben Ayed Hiba , Dorra Ben Nessib , Dhia Kaffel , Kaouther Maatallah , Wafa Hamdi
Introduction
Rheumatoid arthritis and ankylosing spondylitis are among the most common rheumatic diseases. The coexistence of both affections in a single patient is highly infrequent but seems to be underestimated in clinical practice.
Materials and methods
We described the clinical, biological, and radiological characteristics of 12 patients with concomitant rheumatoid arthritis and ankylosing spondylitis diagnosed at our hospital. The 28 disease activity score (DAS28), the Bath ankylosing spondylitis disease activity index (BASDAI), and the Ankylosing Spondylitis Disease Activity Score (ASDAS) were used as outcome measures.
Results
Twelve patients with a male-to-female ratio of 0.71 and a mean age of 62.1 ± 12.8 years were included. Rheumatoid arthritis was the first disease diagnosed in seven patients. The mean duration of rheumatoid arthritis diagnosis at the time of ankylosing spondylitis diagnosis was 20.2 ± 25 months. The first sign of ankylosing spondylitis in rheumatoid arthritis patients was incidental radiological sacroiliitis in four patients, inflammatory low back pain in three patients, and distal interphalangeal joint involvement in hands radiographs in two patients. Rheumatoid arthritis was seronegative in four patients. Erosions were observed on radiographs of the hands and/or feet in 66% of the cases and almost all the patients (11/12) had sacroiliitis on imaging studies. The mean values of the DAS28, ASDAS, and BASDAI scores at the initial diagnosis of rheumatoid arthritis/ankylosing spondylitis were 4.54 ± 1.22, 3.1 ± 0.72, and 4.1 ± 0.5, respectively.
Conclusion
The coexistence of Rheumatoid arthritis and ankylosing spondylitis is uncommon but should be considered. We could not draw a conclusion about whether the association of both disease conditions confers different characteristics.
{"title":"The coexistence of rheumatoid arthritis and ankylosing spondylitis: Case series and literature review","authors":"Hanene Lassoued Ferjani , Ben Ayed Hiba , Dorra Ben Nessib , Dhia Kaffel , Kaouther Maatallah , Wafa Hamdi","doi":"10.1016/j.rcreue.2025.09.004","DOIUrl":"10.1016/j.rcreue.2025.09.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Rheumatoid arthritis and ankylosing spondylitis are among the most common rheumatic diseases. The coexistence of both affections in a single patient is highly infrequent but seems to be underestimated in clinical practice.</div></div><div><h3>Materials and methods</h3><div>We described the clinical, biological, and radiological characteristics of 12 patients with concomitant rheumatoid arthritis and ankylosing spondylitis diagnosed at our hospital. The 28 disease activity score (DAS28), the Bath ankylosing spondylitis disease activity index (BASDAI), and the Ankylosing Spondylitis Disease Activity Score (ASDAS) were used as outcome measures.</div></div><div><h3>Results</h3><div>Twelve patients with a male-to-female ratio of 0.71 and a mean age of 62.1<!--> <!-->±<!--> <!-->12.8 years were included. Rheumatoid arthritis was the first disease diagnosed in seven patients. The mean duration of rheumatoid arthritis diagnosis at the time of ankylosing spondylitis diagnosis was 20.2<!--> <!-->±<!--> <!-->25 months. The first sign of ankylosing spondylitis in rheumatoid arthritis patients was incidental radiological sacroiliitis in four patients, inflammatory low back pain in three patients, and distal interphalangeal joint involvement in hands radiographs in two patients. Rheumatoid arthritis was seronegative in four patients. Erosions were observed on radiographs of the hands and/or feet in 66% of the cases and almost all the patients (11/12) had sacroiliitis on imaging studies. The mean values of the DAS28, ASDAS, and BASDAI scores at the initial diagnosis of rheumatoid arthritis/ankylosing spondylitis were 4.54<!--> <!-->±<!--> <!-->1.22, 3.1<!--> <!-->±<!--> <!-->0.72, and 4.1<!--> <!-->±<!--> <!-->0.5, respectively.</div></div><div><h3>Conclusion</h3><div>The coexistence of Rheumatoid arthritis and ankylosing spondylitis is uncommon but should be considered. We could not draw a conclusion about whether the association of both disease conditions confers different characteristics.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 394-400"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.rcreue.2025.08.001
Pedro Arbey Quevedo Mayorga , Javier Mauricio Mora Méndez , Alejandro Aristizábal , Lilian Marcela Estupiñan Moya , Diana Muñoz
Introduction
Lupus nephritis is a common complication in patients with systemic lupus erythematosus. Cyclophosphamide in induction treatment has a good efficacy profile, but greater toxicity.
Objective
To perform a systematic review and meta-analysis, updating the literature that compares the efficacy and safety of cyclophosphamide at high and low doses.
Materials and methods
PRISMA-P methodology, PROSPERO register number CRD42023485477, only randomized clinical trials were included from 2010 to October 2023, in patients over 16 years of age with lupus nephritis class III, IV, V, or V + III, V + IV. Complete response, partial response, relapses, infections, leukopenia, and amenorrhoea were measured, the RR was estimated for a 95% CI, based on the Mantel-Haenszel method, and heterogeneity by I2 and Q test.
Results
415 articles were found, only three were included with 406 patients, 217 for the high dose group and 189 low doses. There were no statistically significant differences with respect to complete response (RR = 0.77, 95% CI 0.60–1.01, p = 0.06), partial response (RR = 0.88, 95% CI 0.67–1.16, p = 0.35), relapses (RR = 2.16, 95% CI 0.18–24.7, p = 0.52) and infections (RR = 0.68, 95% CI 0.45–1.04, p = 0.08), while leukopenia and amenorrhoea were significantly uncommon in the low dose group (RR = 0.41, 95% CI 0.22–0.77, p = 0.01) and (RR = 0.40, 95% CI 0.25–0.64, p = 0.002).
Conclusions
The use of low-dose cyclophosphamide is as effective as the high-dose regimen and the probability of leukopenia and amenorrhoea is lower.
{"title":"Systematic review and meta-analysis of the low-dose versus high-dose cyclophosphamide regimen for induction treatment in lupus nephritis patients, evidence update 2010–2023","authors":"Pedro Arbey Quevedo Mayorga , Javier Mauricio Mora Méndez , Alejandro Aristizábal , Lilian Marcela Estupiñan Moya , Diana Muñoz","doi":"10.1016/j.rcreue.2025.08.001","DOIUrl":"10.1016/j.rcreue.2025.08.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Lupus nephritis is a common complication in patients with systemic lupus erythematosus. Cyclophosphamide in induction treatment has a good efficacy profile, but greater toxicity.</div></div><div><h3>Objective</h3><div>To perform a systematic review and meta-analysis, updating the literature that compares the efficacy and safety of cyclophosphamide at high and low doses.</div></div><div><h3>Materials and methods</h3><div>PRISMA-P methodology, PROSPERO register number CRD42023485477, only randomized clinical trials were included from 2010 to October 2023, in patients over 16 years of age with lupus nephritis class III, IV, V, or V + III, V + IV. Complete response, partial response, relapses, infections, leukopenia, and amenorrhoea were measured, the RR was estimated for a 95% CI, based on the Mantel-Haenszel method, and heterogeneity by I<sup>2</sup> and Q test.</div></div><div><h3>Results</h3><div>415 articles were found, only three were included with 406 patients, 217 for the high dose group and 189 low doses. There were no statistically significant differences with respect to complete response (RR = 0.77, 95% CI 0.60–1.01, p = 0.06), partial response (RR = 0.88, 95% CI 0.67–1.16, p = 0.35), relapses (RR = 2.16, 95% CI 0.18–24.7, p = 0.52) and infections (RR = 0.68, 95% CI 0.45–1.04, p = 0.08), while leukopenia and amenorrhoea were significantly uncommon in the low dose group (RR = 0.41, 95% CI 0.22–0.77, p = 0.01) and (RR = 0.40, 95% CI 0.25–0.64, p = 0.002).</div></div><div><h3>Conclusions</h3><div>The use of low-dose cyclophosphamide is as effective as the high-dose regimen and the probability of leukopenia and amenorrhoea is lower.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 374-384"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.rcreue.2025.07.002
Kaori Mitchell Gil-Rivasplata, Valeria Katiuska Rojas-Del Aguila, Carlos Manuel Escobar-Galindo, Jesús Martin Trinidad-López
Introduction/objective
Rheumatoid arthritis (RA) primarily affects the hand joints, limiting independence for feeding and requiring the use of assistive technology. The thickening of the handles on the spoon is used as a treatment strategy. However, few studies address how much it helps in RA. Therefore, the study aimed to determine the effect of the use of thickened handle spoons on time, performance quality, and perceived hand effort in the improvement of feeding in users simulating RA with restricted hand movements.
Materials and methods
A quasi-experimental design was used in which RA was simulated with a simulator glove, comparing feeding experiences with regular spoons.
Results
Using spoons with thickened handles had statistically significant effects on the reduction of perceived effort when eating different foods (p = .005); however, there was no significant difference between the number of times food was dropped and the time to complete the activity (p = .78).
Conclusions
Spoons with thickened handles reduce the level of perceived effort, which allows for better joint protection and pain management. It also equals the time and efficiency of eating with a conventional spoon.
{"title":"Use of thickened-handled spoon in improving feeding performance in patients with rheumatoid arthritis","authors":"Kaori Mitchell Gil-Rivasplata, Valeria Katiuska Rojas-Del Aguila, Carlos Manuel Escobar-Galindo, Jesús Martin Trinidad-López","doi":"10.1016/j.rcreue.2025.07.002","DOIUrl":"10.1016/j.rcreue.2025.07.002","url":null,"abstract":"<div><h3>Introduction/objective</h3><div>Rheumatoid arthritis (RA) primarily affects the hand joints, limiting independence for feeding and requiring the use of assistive technology. The thickening of the handles on the spoon is used as a treatment strategy. However, few studies address how much it helps in RA. Therefore, the study aimed to determine the effect of the use of thickened handle spoons on time, performance quality, and perceived hand effort in the improvement of feeding in users simulating RA with restricted hand movements.</div></div><div><h3>Materials and methods</h3><div>A quasi-experimental design was used in which RA was simulated with a simulator glove, comparing feeding experiences with regular spoons.</div></div><div><h3>Results</h3><div>Using spoons with thickened handles had statistically significant effects on the reduction of perceived effort when eating different foods (p = .005); however, there was no significant difference between the number of times food was dropped and the time to complete the activity (p = .78).</div></div><div><h3>Conclusions</h3><div>Spoons with thickened handles reduce the level of perceived effort, which allows for better joint protection and pain management. It also equals the time and efficiency of eating with a conventional spoon.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 351-358"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.rcreue.2025.07.003
{"title":"Errata in articles published in the journal Revista Colombiana de Reumatología in 2023 and 2024","authors":"","doi":"10.1016/j.rcreue.2025.07.003","DOIUrl":"10.1016/j.rcreue.2025.07.003","url":null,"abstract":"","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 421-422"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.rcreue.2025.06.001
Luz Elena Triana Vidal, Armando Lucumi Moreno, Ivonne Valeria Ortiz
Introduction
Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and cellular antioxidant activity. Overproduction of ROS causes oxidative damage to major macromolecules, alters homeostasis and leads to the generation of different pathologies. At present, there is no totally effective treatment to counteract these diseases involved with oxidative stress, so it is necessary to investigate new treatment alternatives that suppress the ROS generated. One promising alternative is the use of plant extracts, which have demonstrated a potent antioxidant effect. Efficient cells for the study of pathological diseases related to reactive oxygen species are T lymphocytes, which share systems with neurons such as: the dopaminergic system, death signaling and survival. In vitro lymphocytes are an optimal model for the evaluation of oxidative mechanisms.
Objective
To determine the protective effect of ethanolic extract of propolis against oxidative damage induced by hydrogen peroxide (H2O2) in human lymphocytes in vitro, by means of the cell viability test with trypan blue.
Results
Anova test shows that the concentrations of 0.0225 and 0.045 mg/mL of ethanolic extract of propolis, present protective activity against cell damage caused by H2O2.
Conclusion
This study proposes the ethanolic extract of propolis as a potential pharmacological, useful for treatments against autoinmune disorders.
{"title":"Protective effect of propolis against oxidative stress induced by hydrogen peroxide in vitro peripheral blood mononuclear cells","authors":"Luz Elena Triana Vidal, Armando Lucumi Moreno, Ivonne Valeria Ortiz","doi":"10.1016/j.rcreue.2025.06.001","DOIUrl":"10.1016/j.rcreue.2025.06.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and cellular antioxidant activity. Overproduction of ROS causes oxidative damage to major macromolecules, alters homeostasis and leads to the generation of different pathologies. At present, there is no totally effective treatment to counteract these diseases involved with oxidative stress, so it is necessary to investigate new treatment alternatives that suppress the ROS generated. One promising alternative is the use of plant extracts, which have demonstrated a potent antioxidant effect. Efficient cells for the study of pathological diseases related to reactive oxygen species are T lymphocytes, which share systems with neurons such as: the dopaminergic system, death signaling and survival. <em>In vitro</em> lymphocytes are an optimal model for the evaluation of oxidative mechanisms.</div></div><div><h3>Objective</h3><div>To determine the protective effect of ethanolic extract of propolis against oxidative damage induced by hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) in human lymphocytes <em>in vitro</em>, by means of the cell viability test with trypan blue.</div></div><div><h3>Results</h3><div>Anova test shows that the concentrations of 0.0225 and 0.045 mg/mL of ethanolic extract of propolis, present protective activity against cell damage caused by H<sub>2</sub>O<sub>2</sub>.</div></div><div><h3>Conclusion</h3><div>This study proposes the ethanolic extract of propolis as a potential pharmacological, useful for treatments against autoinmune disorders.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 315-320"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.rcreue.2025.08.003
Juan Camilo Santacruz , Marta Juliana Mantilla , Sandra Pulido , Ferney Africano , Carlos Alberto Agudelo , Rubén Darío Mantilla , Ángelo Arzuaga , John Londoño
Systemic lupus erythematosus is an autoimmune disease with a tendency to wax and wane. Unlike other autoimmune conditions, disease activity in the gastrointestinal system is relatively rare, and its approach can vary, according to different points of view. Despite its low prevalence, gastrointestinal manifestations can be potentially fatal, as occurs in cases of intestinal vasculitis and the consequent mesenteric ischaemia. The spectrum of gastrointestinal involvement in this disease is broad, and includes disease activity, infection associated with immunosuppression, adverse effects of some medications, or other intercurrent processes such as lupus cystitis. The clinical symptoms and laboratory findings are highly diverse, which leads to a delay in diagnosis with consequent organ dysfunction. Early diagnosis can be a challenge because a large proportion of patients present with nonspecific constitutional symptoms associated with nausea, emesis, and abdominal pain. These numerous factors have been an obstacle to further research in this field, making a unified diagnostic and therapeutic approach difficult. Therefore, an advanced search of the literature will be undertaken to obtain the most evidence available on the diagnostic methods and treatments currently available, providing the clinician with more tools to achieve a comprehensive approach.
{"title":"A practical perspective on gastrointestinal manifestations of systemic lupus erythematosus","authors":"Juan Camilo Santacruz , Marta Juliana Mantilla , Sandra Pulido , Ferney Africano , Carlos Alberto Agudelo , Rubén Darío Mantilla , Ángelo Arzuaga , John Londoño","doi":"10.1016/j.rcreue.2025.08.003","DOIUrl":"10.1016/j.rcreue.2025.08.003","url":null,"abstract":"<div><div>Systemic lupus erythematosus is an autoimmune disease with a tendency to wax and wane. Unlike other autoimmune conditions, disease activity in the gastrointestinal system is relatively rare, and its approach can vary, according to different points of view. Despite its low prevalence, gastrointestinal manifestations can be potentially fatal, as occurs in cases of intestinal vasculitis and the consequent mesenteric ischaemia. The spectrum of gastrointestinal involvement in this disease is broad, and includes disease activity, infection associated with immunosuppression, adverse effects of some medications, or other intercurrent processes such as lupus cystitis. The clinical symptoms and laboratory findings are highly diverse, which leads to a delay in diagnosis with consequent organ dysfunction. Early diagnosis can be a challenge because a large proportion of patients present with nonspecific constitutional symptoms associated with nausea, emesis, and abdominal pain. These numerous factors have been an obstacle to further research in this field, making a unified diagnostic and therapeutic approach difficult. Therefore, an advanced search of the literature will be undertaken to obtain the most evidence available on the diagnostic methods and treatments currently available, providing the clinician with more tools to achieve a comprehensive approach.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 385-393"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.rcreue.2025.09.005
Luis Javier Cajas Santana , Santiago Cuero , Gabriela Guerrero , Mayelin Ceballos , María Carolina Torres , Diana Rocio Gil , Yimy F. Medina , Ana Milena Callejas , Javier Leonardo Galindo , Cesar Riascos , Wilmer Aponte , Diana Ochoa , Jennifer Delgadillo
Introduction
Interstitial lung disease (ILD) is one of the leading causes of mortality in autoimmune diseases. The extent of the disease is a determining factor in the prognosis and treatment initiation and monitoring. Quantification using the Goh method is the most commonly used method; however, it is subjective. So far, no studies have evaluated the level of agreement among various readers.
Objective
The study's objective is to determine the interobserver and intra-observer variability in using ILD quantification among physicians from various specialties and levels of experience.
Methods
Images from chest computed tomography of patients with rheumatoid arthritis (RA) or systemic sclerosis (SSc) and ILD were collected. The five necessary cuts described by Goh were extracted to be evaluated by pulmonologists, rheumatologists, radiologists, fellows, and a thoracic radiologist (gold standard). The interobserver and intra-observer variability values were calculated using the intraclass correlation coefficient test or Cohen's Kappa test, depending on the nature of the variable, between each group of medical specialties and in comparison with the gold standard.
Results
Seventy-nine patients were selected, primarily women, 56% having SSc. A total of 1098 CT scans were performed. The intraclass correlation coefficient was .75 (95% CI: .67–.81), including all nine readers. The best correlation with the gold standard was found among pulmonologists (CCI .83) and rheumatologists (CCI .81). According to severity (more significant or less than 20% extension), the Kappa coefficient was .64 among the nine readers. The intraclass correlation coefficient for the average intra-observer correlation of all readers was .89 (95% CI: .81–.93), and the Kappa coefficient was .82.
Conclusion
The Goh method is valuable and highly correlated among a diverse group of specialties that manage ILD, making it a practical tool for assessing the extent of the disease.
{"title":"Agreement in quantifying the extension of autoimmune-associated interstitial lung disease using the Goh method","authors":"Luis Javier Cajas Santana , Santiago Cuero , Gabriela Guerrero , Mayelin Ceballos , María Carolina Torres , Diana Rocio Gil , Yimy F. Medina , Ana Milena Callejas , Javier Leonardo Galindo , Cesar Riascos , Wilmer Aponte , Diana Ochoa , Jennifer Delgadillo","doi":"10.1016/j.rcreue.2025.09.005","DOIUrl":"10.1016/j.rcreue.2025.09.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Interstitial lung disease (ILD) is one of the leading causes of mortality in autoimmune diseases. The extent of the disease is a determining factor in the prognosis and treatment initiation and monitoring. Quantification using the Goh method is the most commonly used method; however, it is subjective. So far, no studies have evaluated the level of agreement among various readers.</div></div><div><h3>Objective</h3><div>The study's objective is to determine the interobserver and intra-observer variability in using ILD quantification among physicians from various specialties and levels of experience.</div></div><div><h3>Methods</h3><div>Images from chest computed tomography of patients with rheumatoid arthritis (RA) or systemic sclerosis (SSc) and ILD were collected. The five necessary cuts described by Goh were extracted to be evaluated by pulmonologists, rheumatologists, radiologists, fellows, and a thoracic radiologist (gold standard). The interobserver and intra-observer variability values were calculated using the intraclass correlation coefficient test or Cohen's Kappa test, depending on the nature of the variable, between each group of medical specialties and in comparison with the gold standard.</div></div><div><h3>Results</h3><div>Seventy-nine patients were selected, primarily women, 56% having SSc. A total of 1098 CT scans were performed. The intraclass correlation coefficient was .75 (95% CI: .67–.81), including all nine readers. The best correlation with the gold standard was found among pulmonologists (CCI .83) and rheumatologists (CCI .81). According to severity (more significant or less than 20% extension), the Kappa coefficient was .64 among the nine readers. The intraclass correlation coefficient for the average intra-observer correlation of all readers was .89 (95% CI: .81–.93), and the Kappa coefficient was .82.</div></div><div><h3>Conclusion</h3><div>The Goh method is valuable and highly correlated among a diverse group of specialties that manage ILD, making it a practical tool for assessing the extent of the disease.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 368-373"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.rcreue.2025.06.003
Luis Javier Cajas Santana , Daniela Rojas Carvajal , Wendy Torres Chazatar , Laura Mendoza Galindo , Yensi Romero Díaz , Daniel Ramírez Muñoz , Gisella Fernández Salamanca
Introduction
Interstitial lung disease is a significant complication in autoimmune diseases. The extent of involvement is crucial in determining both onset and treatment response. While there are computational methods for this calculation, manual methods, such as the Goh method, remain the most commonly used. However, it has some disadvantages, such as presuming that areas across the lung are equivalent and thus influence the calculation equally. The aim of this study is to analyse these difficulties and find a mathematical correction method.
Materials and methods
High-resolution chest tomography images were obtained from patients with and without ILD. Pulmonary areas were analysed and compared in the slices referenced in the Goh method. Through geometric analysis of lung structure, the slice closest to the average of its areas was identified for comparison with other measurements. Based on this, a correction equation was formulated, and through simulation of various interstitial involvement patterns, the degree of variation was determined.
Results
Images from 80 patients were analysed, mostly women diagnosed with systemic sclerosis. It was found that apical areas (slices 1 and 2) and the sum of left-sided pulmonary areas were 20% smaller compared to basal and right-sided areas, respectively. Simulation with different involvement components found that apical or left-sided disease overestimates extension by 5% to 10%, especially when it exceeds 15%. The third slice was determined to be closest to the average of the areas, and a correction formula was devised based on this.
Conclusions
The Goh method incorrectly assumes the equivalence of pulmonary areas, which can impact calculations. We propose a mathematical correction for this purpose.
{"title":"Analysis of inequalities and correction model of the Goh method used in quantifying interstitial lung disease","authors":"Luis Javier Cajas Santana , Daniela Rojas Carvajal , Wendy Torres Chazatar , Laura Mendoza Galindo , Yensi Romero Díaz , Daniel Ramírez Muñoz , Gisella Fernández Salamanca","doi":"10.1016/j.rcreue.2025.06.003","DOIUrl":"10.1016/j.rcreue.2025.06.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Interstitial lung disease is a significant complication in autoimmune diseases. The extent of involvement is crucial in determining both onset and treatment response. While there are computational methods for this calculation, manual methods, such as the Goh method, remain the most commonly used. However, it has some disadvantages, such as presuming that areas across the lung are equivalent and thus influence the calculation equally. The aim of this study is to analyse these difficulties and find a mathematical correction method.</div></div><div><h3>Materials and methods</h3><div>High-resolution chest tomography images were obtained from patients with and without ILD. Pulmonary areas were analysed and compared in the slices referenced in the Goh method. Through geometric analysis of lung structure, the slice closest to the average of its areas was identified for comparison with other measurements. Based on this, a correction equation was formulated, and through simulation of various interstitial involvement patterns, the degree of variation was determined.</div></div><div><h3>Results</h3><div>Images from 80 patients were analysed, mostly women diagnosed with systemic sclerosis. It was found that apical areas (slices 1 and 2) and the sum of left-sided pulmonary areas were 20% smaller compared to basal and right-sided areas, respectively. Simulation with different involvement components found that apical or left-sided disease overestimates extension by 5% to 10%, especially when it exceeds 15%. The third slice was determined to be closest to the average of the areas, and a correction formula was devised based on this.</div></div><div><h3>Conclusions</h3><div>The Goh method incorrectly assumes the equivalence of pulmonary areas, which can impact calculations. We propose a mathematical correction for this purpose.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 328-334"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.rcreue.2025.06.002
Edgar Santiago Castro Prieto , Carlos Mauricio Martínez Montalvo , Sandra Ximena Ramírez , Valentina Ramírez Vega , Carlos Ernesto Artega Unigarro , Cristian Ivan Aparicio Neisa
Introduction
We present the first case reported in Colombia of Blau syndrome manifested in adults associated with a de novo mutation in the NOD2 gene in the context of a case of fever of unknown origin.
Case summary
44-year-old female patient presenting with a condition of approximately 4 years of evolution consisting of cyclical episodes of quantified fever lasting approximately 20 days, with remission intervals of 6–8 months, accompanied by generalized abdominal pain, polymyalgia, polyarthralgia, and general discomfort. Her medical history included treated liver tuberculosis (TB), anterior uveitis, appearance of erythema nodosum in the lower limbs with spontaneous remission, and an episode of peripheral facial paralysis. During the aetiological studies, hepatic granulomas were documented, which were taken to biopsy where multiple non-caseating granulomas were found. Angiotensin-converting enzyme levels were measured, which were found within normal limits, and molecular and microbiological limits for tuberculosis in the biopsy were negative. Subsequently, an autoinflammatory syndrome was considered a suspected diagnostic diagnosis given the persistence of the condition, so genetic studies were performed where a de novo heterozygous mutation was detected in the NOD2 gene, which is associated with Blau syndrome.
Conclusions
Autoinflammatory syndromes, although they occur mostly in childhood, should not be ruled out in adults. In our country there are no known cases of Blau syndrome manifesting in adulthood, so this case report will help us inform the scientific community about it.
{"title":"Blau syndrome as a cause of fever of unknown origin in adults: A case report","authors":"Edgar Santiago Castro Prieto , Carlos Mauricio Martínez Montalvo , Sandra Ximena Ramírez , Valentina Ramírez Vega , Carlos Ernesto Artega Unigarro , Cristian Ivan Aparicio Neisa","doi":"10.1016/j.rcreue.2025.06.002","DOIUrl":"10.1016/j.rcreue.2025.06.002","url":null,"abstract":"<div><h3>Introduction</h3><div>We present the first case reported in Colombia of Blau syndrome manifested in adults associated with a de novo mutation in the NOD2 gene in the context of a case of fever of unknown origin.</div></div><div><h3>Case summary</h3><div>44-year-old female patient presenting with a condition of approximately 4 years of evolution consisting of cyclical episodes of quantified fever lasting approximately 20 days, with remission intervals of 6–8 months, accompanied by generalized abdominal pain, polymyalgia, polyarthralgia, and general discomfort. Her medical history included treated liver tuberculosis (TB), anterior uveitis, appearance of erythema nodosum in the lower limbs with spontaneous remission, and an episode of peripheral facial paralysis. During the aetiological studies, hepatic granulomas were documented, which were taken to biopsy where multiple non-caseating granulomas were found. Angiotensin-converting enzyme levels were measured, which were found within normal limits, and molecular and microbiological limits for tuberculosis in the biopsy were negative. Subsequently, an autoinflammatory syndrome was considered a suspected diagnostic diagnosis given the persistence of the condition, so genetic studies were performed where a de novo heterozygous mutation was detected in the NOD2 gene, which is associated with Blau syndrome.</div></div><div><h3>Conclusions</h3><div>Autoinflammatory syndromes, although they occur mostly in childhood, should not be ruled out in adults. In our country there are no known cases of Blau syndrome manifesting in adulthood, so this case report will help us inform the scientific community about it.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 401-408"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号