Revista Colombiana de Reumatología (English Edition)最新文献

Capillaroscopic findings in individuals with Sjögren’s syndrome, systemic sclerosis, and primary Raynaud’s phenomenon at a capillaroscopy referral centre in Medellin, Colombia 在哥伦比亚麦德林的一个毛细血管镜检查转诊中心，对Sjögren综合征、系统性硬化症和原发性雷诺氏现象患者的毛细血管镜检查结果

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2026-01-01 Epub Date: 2026-02-23 DOI: 10.1016/j.rcreue.2026.102165

Simón Hoyos-Patiño , Alejandro Arango-Martínez , Libia María Rodriguez-Padilla , Andrés Chavarriaga-Restrepo , Carlos Jaime Velasquez-Franco

Introduction

Nailfold capillaroscopy is a fundamental technique for studying systemic autoimmune diseases such as Sjögren’s syndrome, particularly in patients with Raynaud’s phenomenon and sclerodermiform features. However, in this condition, studies are scarce and often use instruments less precise than digital videocapillaroscopy, limiting the available evidence.

Objective

To compare capillaroscopic findings among individuals with Sjögren's syndrome (SS), primary Raynaud's phenomenon (PRP), and systemic sclerosis (SSc) at a national referral centre for nailfold videocapillaroscopy in Medellin, Colombia, between 2016 and 2022.

Materials and methods

An analytical cross-sectional observational study that included individuals over 18 years of age with SS, SSc, and PRP. Clinical and capillaroscopic characteristics information was obtained from capillaroscopy reports at an expert centre. Pearson's chi-square test was used to compare qualitative variables, and the Kruskal-Wallis test for quantitative variables. A P-value <.05 was considered statistically significant.

Results

A total of 195 patients were included. Subjects with SS had a lower prevalence of abnormal capillaroscopic variables than patients with SSc (P < .001). All abnormal capillaroscopic variables were more frequent in the SS group compared to PRP. There were statistically significant differences among the three patient groups in the capillaroscopic pattern (P < .001). The main capillaroscopic finding in SS was the presence of dilated capillaries (55.4%; 36/65). In the SS group, an early scleroderma pattern was present in 4.6%, and an active scleroderma pattern in 13.8%, both findings less frequent than in SSc but more common than in PRP.

Conclusions

In a population of SS patients with a high prevalence of secondary Raynaud's phenomenon and anticentromere antibodies, a high prevalence of capillaroscopic abnormalities was found. Although less frequent compared to the SSc group, these abnormalities were more common than in the PRP group.

甲襞毛细血管镜检查是研究系统性自身免疫性疾病（如Sjögren综合征）的一项基本技术，特别是在有雷诺现象和硬皮样特征的患者中。然而，在这种情况下，研究很少，而且通常使用的仪器不如数字视频毛细血管镜精确，限制了可用的证据。目的比较2016年至2022年在哥伦比亚麦德林的一个国家甲折视频毛细血管镜转诊中心，Sjögren综合征（SS）、原发性雷诺现象（PRP）和系统性硬化症（SSc）患者的毛细血管镜检查结果。材料和方法一项分析性横断面观察研究，包括18岁以上的SS、SSc和PRP患者。临床和毛细血管镜特征信息从专家中心的毛细血管镜检查报告中获得。定性变量比较采用Pearson卡方检验，定量变量比较采用Kruskal-Wallis检验。p值<； 0.05被认为具有统计学意义。结果共纳入195例患者。与SSc患者相比，SS患者的毛细血管镜变量异常发生率较低（P < .001）。与PRP组相比，SS组的所有毛细血管镜异常变量都更频繁。三组患者在毛细管镜模式上差异有统计学意义（P < 0.001）。SS的主要毛细血管镜检查结果是毛细血管扩张（55.4%;36/65）。在SS组中，4.6%的患者出现早期硬皮病，13.8%的患者出现活动性硬皮病，这两种情况都比SSc少，但比PRP更常见。结论继发性雷诺现象和抗着丝点抗体高发的SS患者中，毛细血管镜下异常高发。虽然与SSc组相比，这些异常发生率较低，但比PRP组更常见。

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引用次数: 0

The significance of inflammatory markers derived from blood cell counts in predicting rheumatoid arthritis among the elderly 来自血细胞计数的炎症标志物在预测老年人类风湿关节炎中的意义

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2026-01-01 Epub Date: 2026-03-13 DOI: 10.1016/j.rcreue.2026.102157

Nabaa S. Abdul-Sahib , Majid M. Mahmood , Ali H. Ad’hiah

Introduction

The systemic immune inflammation index and neutrophil-platelet-to-lymphocyte–hemoglobin ratio are blood-cell-based markers that have recently been described as significant predictors of systemic inflammation in related diseases. However, these markers have not been studied in rheumatoid arthritis and their relationship to aging has not been explored.

Materials and methods

In this case–control study, systemic immune inflammation index and neutrophil-platelet-to-lymphocyte–hemoglobin ratio were analyzed in two age groups of rheumatoid arthritis patients: <40 years (young adults; RA_Y) and >60 years (elderly; RA_E). Similar control groups were included (HC_Y and HC_E, respectively). Each group consisted of 50 individuals (total number = 200) with a 1:1 male-to-female ratio.

Results

Systemic immune inflammation index and neutrophil-platelet-to-lymphocyte–hemoglobin ratio were significantly elevated in RA_Y and RA_E compared to HC_Y and HC_E, respectively. Neutrophil-platelet-to-lymphocyte–hemoglobin ratio was also significantly elevated in RA_E compared to RA_Y. When systemic immune inflammation index and neutrophil-platelet-to-lymphocyte–hemoglobin ratio were stratified by gender, disease duration, disease activity, or therapy type, no significant differences were found. Disease duration in RA_Y was an exception, and systemic immune inflammation index and neutrophil-platelet-to-lymphocyte–hemoglobin ratio gradually decreased with increasing disease duration. Neutrophil-platelet-to-lymphocyte–hemoglobin ratio showed a very good performance in distinguishing between RA_E and HC_E (area under the curve = .831). Neutrophil-platelet-to-lymphocyte–hemoglobin ratio was also a significant marker in increasing the risk of rheumatoid arthritis (1.20-fold), particularly in the elderly (1.33-fold). The two blood-cell-based markers showed strong positive pairwise correlations in RA_Y and RA_E.

Conclusion

The study indicates for the first time that the blood-cell-based inflammatory markers, systemic immune inflammation and neutrophil-platelet-to-lymphocyte–hemoglobin ratio, are cost-effective predictors of rheumatoid arthritis and are associated with the risk of developing the disease, especially in the elderly.

全身性免疫炎症指数和中性粒细胞-血小板-淋巴细胞-血红蛋白比率是基于血细胞的标志物，最近被描述为相关疾病全身性炎症的重要预测指标。然而，这些标志物尚未在类风湿关节炎中进行研究，它们与衰老的关系也尚未探讨。材料与方法在本病例对照研究中，分析了40岁（年轻成人；RAY）和60岁（老年；RAE）两组类风湿关节炎患者的全身免疫炎症指数和中性粒细胞-血小板-淋巴细胞-血红蛋白比值。对照组与对照组相似（分别为HCY组和HCE组）。每组50只（总数200只），男女比例为1:1。结果RAY组和RAE组的全身免疫炎症指数和中性粒细胞-血小板-淋巴细胞-血红蛋白比值均显著高于HCY组和HCE组。与RAY相比，RAE中中性粒细胞-血小板-淋巴细胞-血红蛋白比率也显著升高。当系统免疫炎症指数和中性粒细胞-血小板与淋巴细胞-血红蛋白比率按性别、病程、疾病活动度或治疗类型分层时，未发现显著差异。RAY的病程除外，全身免疫炎症指数和中性粒细胞-血小板-淋巴细胞-血红蛋白比值随着病程的增加而逐渐降低。中性粒细胞-血小板-淋巴细胞-血红蛋白比值对RAE和HCE具有很好的鉴别作用（曲线下面积= .831）。中性粒细胞-血小板-淋巴细胞-血红蛋白比率也是增加类风湿关节炎风险的重要标志（1.20倍），特别是在老年人中（1.33倍）。这两种基于血细胞的标志物在RAY和RAE中显示出强烈的正两两相关。结论该研究首次表明，基于血细胞的炎症标志物，全身免疫炎症和中性粒细胞-血小板-淋巴细胞-血红蛋白比率是类风湿性关节炎的经济预测指标，并且与疾病发生风险相关，特别是在老年人中。

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引用次数: 0

TREX1 c.590C>T variant as a cause of monogenic systemic lupus erythematosus in a 10-year-old girl: case report TREX1 c.590C>T变异体作为10岁女孩单基因系统性红斑狼疮的病因：病例报告

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2026-01-01 Epub Date: 2026-02-27 DOI: 10.1016/j.rcreue.2025.102161

Leosirlay Rojas-Gómez , Adriana Díaz-Maldonado , María Fernanda Reina-Ávila

Juvenile systemic lupus erythematosus is a chronic, autoimmune, and multisystemic disease that affects individuals under 18 years of age. Its early onset suggests a strong genetic relationship, with identified genetic variants causing monogenic systemic lupus erythematosus. The case of a 10-year-old patient with juvenile systemic lupus erythematosus is reported, presenting atypically, severely, and with failure to respond to standard treatment, in whom a variant in the TREX1 gene c.590C>T, p.Ala197Val was identified. TREX1 variants represent up to 2% of systemic lupus erythematosus cases and should be considered in children with early onset, atypical, and severe presentation.

青少年系统性红斑狼疮是一种慢性、自身免疫性和多系统疾病，影响18岁以下的个体。它的早期发病表明有很强的遗传关系，已确定的遗传变异导致单基因系统性红斑狼疮。报告一例10岁少年系统性红斑狼疮患者，表现不典型，严重，标准治疗无效，其中TREX1基因c.590C>；T, p.Ala197Val变异。TREX1变异占系统性红斑狼疮病例的2%，在早期发病、非典型和严重症状的儿童中应予以考虑。

引用次数: 0

Schnitzler syndrome: A deep insight into a rare medical disorder 施尼茨勒综合征：深入了解一种罕见的医学疾病

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2026-01-01 Epub Date: 2026-02-18 DOI: 10.1016/j.rcreue.2026.102164

Luisa Fernanda Jiménez Arcia , Gloria Vásquez Duque

Schnitzler syndrome is a rare autoinflammatory syndrome, in most cases, its characteristic features are chronic urticaria and monoclonal gammopathy. Over 300 cases have been reported worldwide since its discovery, more frequently in Europe than other regions such as North America, Japan, and Latin America. No predisposing conditions or inheritance pattern associated with this disease have been identified to date. However, it seems that disruption of interleukin 1 (IL-1) homeostasis plays an important role as the main pathophysiological mechanism. The main complications described associated with this disease are malignant lymphoproliferative disorders or the development of amyloidosis. Treatment consists primarily of IL-1 blockade and this has shown significant control of clinical symptoms. In this review we aim to take an in-depth look at the possible pathophysiological mechanisms of this rare entity.

Schnitzler综合征是一种罕见的自身炎症综合征，多数病例的特征性表现为慢性荨麻疹和单克隆性伽玛病。自发现以来，全世界已报告了300多例病例，在欧洲比北美、日本和拉丁美洲等其他地区更为频繁。到目前为止，还没有发现与这种疾病相关的易感条件或遗传模式。然而，白细胞介素1 （IL-1）稳态的破坏似乎是主要的病理生理机制。与本病相关的主要并发症是恶性淋巴增生性疾病或淀粉样变的发展。治疗主要包括IL-1阻断，这已显示出临床症状的显著控制。在这篇综述中，我们的目的是深入探讨这种罕见的实体可能的病理生理机制。

引用次数: 0

The impact of implementing a pharmaceutical service in consultations with patients with rheumatoid arthritis 在类风湿关节炎患者的咨询中实施药物服务的影响

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2026-01-01 Epub Date: 2026-01-19 DOI: 10.1016/j.rcreue.2025.102185

Sebastián Ospina Pérez , Evanny S. Valencia Patiño , Daniel Efrén Rodríguez Ariza , Juan C. Díaz Coronado , Carolina Pérez Ríos

Introduction

Rheumatoid arthritis (RA) is an autoimmune, chronic disease with significant morbidity, often hindered by access barriers to therapy.

Objective

To assess the effect of a pharmaceutical service in an outpatient rheumatology unit that dispensed medications at the end of the consultation.

Material and methods

An observational-analytical, retrospective study tracking a cohort of RA patients (before and after the introduction of the pharmacy service). Bivariate analysis was conducted using the Chi-square test, and multivariate analysis using a regression model with the variables disease remission (DAS28 (ESR) < 2.6) and moderate-to-high RA activity (DAS28 (ESR) > 3.2).

Results

A total of 544 patients were included, of which 435 (80.0%) were female. Remission was observed in 266 (48.9%) patients before and 384 (70.6%) after implementation of the pharmaceutical service. Factors associated with RA remission included biological therapy (HR .37 95% CI .25–.56), corticosteroid therapy (HR .31 95% CI .21–.44), leflunomide (HR .55 95% CI .42–.72), sulfasalazine (HR .60 95% CI .42–.86), and having access to the pharmaceutical service (HR 2.93 95% CI 2.23–3.85).

Conclusions

Implementing a pharmaceutical service that dispenses medications for rheumatoid arthritis immediately after consultation was associated with disease remission.

类风湿性关节炎（RA）是一种自身免疫性慢性疾病，发病率高，常因治疗障碍而受阻。目的评价门诊风湿病科在会诊结束时配药服务的效果。材料与方法对一组RA患者（引入药房服务前后）进行观察分析、回顾性研究。双变量分析采用卡方检验，多变量分析采用疾病缓解（DAS28 (ESR) > 2.6）和中高RA活性（DAS28 (ESR) > 3.2）的回归模型。结果共纳入544例患者，其中女性435例（80.0%）。实施药学服务前缓解266例（48.9%），实施药学服务后缓解384例（70.6%）。与RA缓解相关的因素包括生物治疗（HR）。37 95% ci .25。56)，皮质类固醇治疗(HR。31 95% ci .21。44)，来氟米特(HR。55 95%可信区间0.42。72)，柳氮磺胺吡啶(HR。60 95%可信区间0.42。86)，以及获得药品服务（HR 2.93 95%可信区间2.23-3.85）。结论：类风湿关节炎患者会诊后立即配药与疾病缓解相关。

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引用次数: 0

Narrative review: Mesenchymal stem cells derived from the umbilical cord and osteoarthritis 叙述性回顾：来自脐带和骨关节炎的间充质干细胞

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2026-01-01 Epub Date: 2026-02-27 DOI: 10.1016/j.rcreue.2026.504859

Sofía Arias-Correal , Ana María Santos , María Helena Pedraza , John Londoño , Igor Rueda-Cárdenas , Keisy Orduz-Uribe , Laura Manuela Olarte-Bermúdez , Luz Mabel Ávila-Portillo

Osteoarthritis (OA) is the leading cause of articular pain in adult patients, with a high worldwide prevalence and a trend towards increasing. By 2050, 642 million people are expected to suffer from knee OA. Current treatment focuses on measures to prevent progressive joint wear and control symptoms such as pain. Research in regenerative medicine, including the infiltration of platelet-rich plasma, has not yet provided solid evidence for its efficacy. With the advent of cellular therapy, the isolation and expansion of mesenchymal stem cells (MSCs) from various origins have shown promise in reducing inflammation and creating a suitable environment for the regeneration of articular cartilage. This narrative review focuses on umbilical cord-derived mesenchymal stem cells (UC-MSCs), which have certain advantages over other types of MSCs. It summarizes the various clinical trials conducted in recent years, based on a search of multiple databases.

骨关节炎（OA）是成人患者关节疼痛的主要原因，在世界范围内具有很高的患病率，并有增加的趋势。到2050年，预计将有6.42亿人患有膝关节炎。目前的治疗重点是预防关节磨损和控制疼痛等症状。再生医学的研究，包括富血小板血浆的浸润，尚未为其疗效提供确凿的证据。随着细胞疗法的出现，各种来源的间充质干细胞（MSCs）的分离和扩增显示出减少炎症和为关节软骨再生创造合适环境的希望。本文综述了脐带来源的间充质干细胞（UC-MSCs），它比其他类型的间充质干细胞具有一定的优势。通过对多个数据库的检索，总结了近年来进行的各种临床试验。

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引用次数: 0

Chronic diarrhea as initial manifestation of polyarteritis nodosa: A case-based review 慢性腹泻是结节性多动脉炎的初始表现：一个基于病例的回顾

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2026-01-01 Epub Date: 2026-03-13 DOI: 10.1016/j.rcreue.2026.102174

Paul J. Tejada-Llacsa , Julia Sumire Umes , Manuel Francisco Ugarte-Gil , Graciela S. Alarcón , Víctor Román Pimentel-Quiroz

Introduction

Polyarteritis nodosa is a rare form of vasculitis which affects medium and small arteries. Gastrointestinal involvement occurs in 14–65% of patients, the most common symptom being abdominal pain; in a few cases, intestinal perforation may occur. Chronic diarrhea at disease onset is, however, very uncommon.

Objective

To present the case of an elderly man with chronic diarrhea as the main manifestation of polyarteritis nodosa that progressed to intestinal perforation.

Material and methods

The diagnosis of polyarteritis nodosa was made by intestinal biopsy; cyclophosphamide was administered as induction treatment with progressive clinical improvement. Furthermore, a PubMed literature review was conducted.

Results

Three communications on which diarrhea was reported as a manifestation of polyarteritis nodosa; in one of these patients, a 13-year-old girl, chronic diarrhea was the main manifestation.

Conclusion

This case illustrates the diagnostic complexity of polyarteritis nodosa due to non-specific symptoms and atypical presentation such as diarrhea, underscoring the importance for early recognition and intervention.

结节性多动脉炎是一种少见的血管炎，主要累及中、小动脉。14-65%的患者累及胃肠道，最常见的症状是腹痛；少数病例可发生肠穿孔。然而，发病时的慢性腹泻非常罕见。目的报告1例以慢性腹泻为主要表现的老年男性结节性多动脉炎发展为肠穿孔的病例。材料与方法采用肠活检诊断结节性多动脉炎；环磷酰胺作为诱导治疗，临床逐渐改善。此外，我们还进行了PubMed文献综述。结果以腹泻为结节性多动脉炎表现的3次通信；其中一名13岁女孩的主要症状是慢性腹泻。结论本例结节性多动脉炎因其非特异性症状和不典型表现（如腹泻）而具有诊断复杂性，强调早期识别和干预的重要性。

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引用次数: 0

Silicone breast implant-related illness or breast implant-related “ASIA” syndrome: Expert consensus 硅胶乳房植入物相关疾病或乳房植入物相关“亚洲”综合征：专家共识

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2026-01-01 Epub Date: 2026-02-28 DOI: 10.1016/j.rcreue.2026.102186

Andrés A. Hormaza-Jaramillo , Damaris Romero Chamorro , Yeison Santamaría Alza , Alejandro Duque Restrepo , David Enrique Guarín Sastre , Jaime Eduardo Pachón Suárez , María Isabel Cadena Ríos , Diana Rocío Gil Calderón , Daniel G. Fernández-Ávila , Felipe Mesa Betancur , Gloria María Vásquez D. , Héctor Ernesto Barbosa Landínez , Adriana Rojas-Villarraga

Introduction

Breast augmentation surgeries are very common, but in recent years there has been a growing interest in their possible relationship with the appearance of nonspecific symptoms and signs, as well as the development of autoimmune disorders. The lack of a consensus about the syndrome is a controversial issue for the scientific community and generates uncertainty among women with breast implants in Colombia.

Objective

To provide guidelines for the evaluation, approach, and follow-up of silicone breast implant-related disease, or ASIA syndrome, based on evidence and clinical expert opinion.

Methods

Experts from the Colombian Society of Rheumatology and the Colombian Society of Plastic Surgery and an independent methodological team developed a systematic literature review and consensus using a modified Delphi method.

Results

The evidence for an association between silicone breast implants and the development of symptoms, autoimmune or rheumatic diseases is limited, and a definitive causal relationship has not been demonstrated. The low certainty of the evidence is due to bias, study heterogeneity, and non-specific, self-reported symptoms. On this basis, 22 consensus statements were formulated, highlighting the importance of an individualized medical approach, comprehensive evaluation, and effective communication with patients about risks and expectations before implantation and explantation procedures.

Conclusions

Evaluation and therapeutic decisions in women with suspected silicone implant-associated disease should be based on available scientific evidence. Future research should explore the causality of the syndrome and improve disease characterization.

隆胸手术很常见，但近年来，人们对隆胸手术与非特异性症状和体征以及自身免疫性疾病的发展之间可能存在的关系越来越感兴趣。对该综合征缺乏共识是科学界的一个有争议的问题，并在哥伦比亚隆胸妇女中产生了不确定性。目的基于证据和临床专家意见，为硅胶乳房植入物相关疾病（ASIA综合征）的评估、方法和随访提供指导。方法哥伦比亚风湿病学会和哥伦比亚整形外科学会的专家和一个独立的方法学团队使用改进的德尔菲法进行了系统的文献综述和共识。结果硅胶乳房植入物与症状、自身免疫性疾病或风湿性疾病之间存在关联的证据有限，并且尚未证实明确的因果关系。证据的低确定性是由于偏倚、研究异质性和非特异性、自我报告的症状。在此基础上，制定了22项共识声明，强调了个性化医疗方法，全面评估以及在植入和外植体手术前与患者有效沟通风险和期望的重要性。结论对怀疑有硅胶植入物相关疾病的妇女进行评估和治疗决策应基于现有的科学证据。未来的研究应探讨该综合征的因果关系，完善疾病表征。

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引用次数: 0

Can cardiovascular risk factors affect the result of nailfold videocapillaroscopy? A retrospective multicentre study 心血管危险因素会影响甲襞内镜检查结果吗？一项多中心回顾性研究

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2026-01-01 Epub Date: 2026-02-26 DOI: 10.1016/j.rcreue.2026.102171

Eva Álvarez Andrés , Eugenio de Miguel , Laura Nuño Nuño , Paloma García de la Peña Lefebvre , Itsaso Losantos , Alejandro Balsa , Paloma Turiel , Nuria Garvin , Manuel Beladiez , Camila Tapia , Cristina Zamora , Ana Belén Rodriguez , Clara Sangüesa , Patricia López , Rocío Mustienes , Ana Cruz

Objectives

Nailfold capillaroscopy (NC) is used in the study of Raynaud’s phenomenon (RPh). Many people have cardiovascular risk factors (CVRF): tobacco (TOB), diabetes (DM), alcohol (ALC), dyslipidaemia (DL), arterial hypertension (HT), and obesity (OBE). The objective of the work was to investigate whether CVRF produce capillaroscopic alterations, which could influence their final interpretation.

Methods

Multicentre descriptive retrospective study of patients referred to CP consultation for RPh or suspected connective tissue disease in two Madrid hospitals between 2015 and 2018. 200x videocapillaroscopy (Dinolite®) was used. Analytical, clinical, therapeutic variables, CVRF, and capillaroscopic alterations (tortuosities, ramifications, dilations, giant capillaries, decreased density, and haemorrhages) were collected. For the statistical study, parametric and non-parametric tests were used (statistical significance at p < .05).

Results

340 medical records were reviewed, 286 (84.1%), mean age of 52.36±16.97 years; 270 had RPh (79.4%) and 212 (62.4%) CVRF: 108 TOB (31.8%), 108 DL (31.8%), 62 H T (18.2%), 20 DM (5.8%), 8 ALC (2.4%). Three groups were formed: 155 primary RPh (45.6%), 123 with connective tissue disease (36.2%) and 62 with other osteoarticular diseases (18.2%). The statistical study showed an association between all capillaroscopic alterations and CVRF (p < .001), as well as between: decreased density with HT (p = 0.006); tortuosities with HT (p < .001) and hypercholesterolaemia (p = .006); Dilations, ramifications, haemorrhages with HT (p < .001, p = .019, and p = .008) and TOB (p < .001, p = .019, and p = .002); giant capillaries with TOB (p = .034).

Conclusions

This work shows the association between capillaroscopic alterations and CVRF, which should be considered for correct CP interpretation.

目的应用甲襞毛细管镜（NC）研究雷诺现象（RPh）。许多人都有心血管危险因素（CVRF）：烟草（TOB）、糖尿病（DM）、酒精（ALC）、血脂异常（DL）、动脉高血压（HT）和肥胖（OBE）。这项工作的目的是调查CVRF是否会产生毛细管镜下的改变，这可能会影响他们的最终解释。方法对2015年至2018年马德里两家医院因RPh或疑似结缔组织病就诊的CP患者进行多中心描述性回顾性研究。使用200倍视频毛细管镜（Dinolite®）。收集分析、临床、治疗变量、CVRF和毛细血管镜改变（弯曲、分叉、扩张、巨大毛细血管、密度降低和出血）。统计学研究采用参数检验和非参数检验（p < 0.05）。结果共查阅病历340份，286份（84.1%），平均年龄52.36±16.97岁；270年气道(79.4%)和212年(62.4%)CVRF: 108 TOB(31.8%)、108年DL(31.8%)、62 H T(18.2%)、20 DM(5.8%), 8酒精度(2.4%)。原发性RPh 155例（45.6%），结缔组织病123例（36.2%），其他骨关节疾病62例（18.2%）。统计研究显示所有毛细血管镜改变与CVRF之间存在关联（p <）。0.001)，以及：HT降低密度（p = 0.006）；腰痛合并HT （p < .001）和高胆固醇血症（p = .006）；扩张，分支，HT出血（p <）001, p =。019, p =。2008)和TOB (p <；001, p =。019, p = .002)；巨毛细血管伴TOB （p = 0.034）。结论本研究显示了毛细血管镜下改变与CVRF之间的联系，这应该被考虑到正确的CP解释。

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引用次数: 0

Relapses in idiopathic inflammatory myopathies: a perspective from the Colombian clinical experience 特发性炎症性肌病的复发：从哥伦比亚临床经验的角度

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2026-01-01 Epub Date: 2026-02-19 DOI: 10.1016/j.rcreue.2026.504881

Andrés Hormaza-Jaramillo

引用次数: 0