Revista Colombiana de Reumatología (English Edition)最新文献_第5页

Evaluation of clinical, scintigraphic, and histopathological features in patients with patients with a presumptive diagnosis of Sjögren’s syndrome 推定诊断为Sjögren综合征的患者的临床、影像学和组织病理学特征的评估

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-07-01 Epub Date: 2025-04-22 DOI: 10.1016/j.rcreue.2025.03.006

Lina María Franco González , Leonor Victoria González Pérez , Mónica Vanessa Posso Zapata , Vanessa Andrea Flórez Arango

Introduction

Sicca syndrome is characterized by the presence of dry eye (xerophthalmia - keratoconjunctivitis sicca), dry mouth (xerostomia), and dry skin (xeroderma), this triad may be related to Sjögren’s syndrome.

Objective

To associate the clinical, scintigraphic, and histopathological characteristics of patients with xerostomia and diagnosis of SS and presumptive diagnosis of Sjögren's syndrome in Medellín-Colombia, 2018–2020.

Materials and methods

The study was a quantitative approach, with cross-sectional analysis. The participants were grouped into two groups: diagnosis of Sicca syndrome and presumptive diagnosis of Sjögren's syndrome, and a survey of sociodemographic data was applied. For each group, salivary flow measurements, Schirmer’s test, salivary gland scintigraphic study, and histological evaluation were performed. Statistical analysis was performed using measures of central tendency (median) and dispersion (interquartile range), Fisher’s exact test, and the Wilcoxon test (U Man-Whitney).

Results

The total sample studied consisted of 24 women, whose most frequent systemic clinical symptom was joint pain in Sicca syndrome (90%), and in the group of presumptive diagnosis of Sjögren’s syndrome (92.9%), while the most frequent sign was tongue depapillation in Sicca syndrome (100%) and in the group of presumptive diagnosis of Sjögren’s syndrome (92.9%). Functional tests, unstimulated salivary flow rate, and salivary gland scintigraphy showed greater involvement in the group of presumptive diagnosis of Sjögren’s syndrome. Histopathological analysis showed atrophic changes, fibrosis, and fatty changes in both categories.

Conclusion

The findings suggest that patients with a presumptive diagnosis of Sicca syndrome may be in an early phase of Sjögren's syndrome progression, so this study aims to establish an association of signs, symptoms, and diagnostic aids to define an accurate diagnosis and therapy.

干燥综合征以干眼（干眼症-干燥性角膜结膜炎）、口干（口干症）和皮肤干燥（干皮病）为特征，这三种症状可能与Sjögren综合征有关。目的探讨2018-2020年Medellín-Colombia地区口干症患者的临床、影像学和组织病理学特征与SS诊断和Sjögren综合征推定诊断的相关性。材料与方法本研究采用定量方法，采用横断面分析。参与者被分为两组：诊断为Sicca综合征和推定诊断为Sjögren综合征，并采用社会人口学数据调查。对各组进行唾液流量测量、Schirmer试验、唾液腺显影研究和组织学评价。采用集中趋势（中位数）和离散度（四分位数范围）、Fisher精确检验和Wilcoxon检验（U Man-Whitney）进行统计分析。结果本组共24例女性，其中最常见的全身临床症状为关节疼痛（90%），推定诊断为Sjögren综合征组（92.9%），最常见的体征为舌脱毛（100%）和推定诊断为Sjögren综合征组（92.9%）。功能测试、非刺激唾液流速和唾液腺闪烁成像显示，在推定诊断Sjögren综合征的组中，参与程度更高。组织病理学分析显示两类患者均出现萎缩、纤维化和脂肪变化。结论推定为Sicca综合征的患者可能处于Sjögren综合征进展的早期阶段，因此本研究旨在建立体征、症状和诊断辅助工具的关联，以确定准确的诊断和治疗。

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引用次数: 0

Utility of radiofrequency echographic multi spectrometry in the diagnosis of osteoporosis 射频超声多光谱法在骨质疏松症诊断中的应用

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-07-01 Epub Date: 2025-04-15 DOI: 10.1016/j.rcreue.2025.03.005

Juan Felipe Betancur , Luz Eugenia Pérez , Verónica Bernal González , José Fernando Molina Restrepo

Osteoporosis is a skeletal disorder characterized by decreased bone mineral density (BMD) and a disruption of bone microarchitecture, leading to an increased fracture risk. Traditionally, BMD has been measured using X-ray densitometry (DXA). However, Radiofrequency Echographic Multi Spectometry (REMS) has emerged as a promising technique for the assessment of osteoporosis. Various studies have evaluated the feasibility and precision of REMS, showing significant correlations with DXA in different anatomical sites and populations, including post-menopausal women, renal transplant patients, and those with rheumatoid arthritis, among others. REMS has also demonstrated the ability to detect bone artifacts and provide reliable measurements in their presence. While DXA remains the gold standard for diagnosing osteoporosis, REMS has proven to be an effective and promising tool in assessing BMD and fracture risk. Its capability to rule out artifacts and offer precise measurements in diverse populations highlights its potential as a complement or alternative in the evaluation of osteoporosis.

骨质疏松症是一种骨骼疾病，其特征是骨密度（BMD）下降和骨微结构破坏，导致骨折风险增加。传统上，骨密度是用x射线密度测定法（DXA）测量的。然而，射频超声多谱法（REMS）已成为一种很有前途的骨质疏松症评估技术。各种研究已经评估了REMS的可行性和准确性，显示了不同解剖部位和人群中DXA的显著相关性，包括绝经后妇女、肾移植患者和类风湿关节炎患者等。REMS还展示了检测骨假物的能力，并在其存在时提供可靠的测量。虽然DXA仍然是诊断骨质疏松症的金标准，但REMS已被证明是评估骨密度和骨折风险的有效且有前途的工具。它能够排除人为因素，并在不同人群中提供精确的测量，这突出了它作为骨质疏松症评估的补充或替代方法的潜力。

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引用次数: 0

Retrospective study on the effectiveness of ultrasound-guided interdigital injection of botulinum toxin for the treatment of Raynaud's phenomenon 超声引导下指间注射肉毒毒素治疗雷诺氏症疗效的回顾性研究

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-07-01 Epub Date: 2025-04-25 DOI: 10.1016/j.rcreue.2025.03.001

Ángel Estuardo Plasencia Ezaine , Marco Aurelio Ramírez Huaranga , Rocío Arenal López , David Castro Corredor , Verónica Salas Manzanedo , María Dolores Mínguez Sánchez , Elisa Sánchez Rodríguez

Introduction

Raynaud's phenomenon (RP) is a vasospastic condition that carries a significant burden of pain and disability. When conventional therapies are not sufficiently effective, the need arises to explore other therapeutic alternatives such as interdigital botulinum toxin (BT) injection.

Objective

To determine clinical improvement in patients with RP (number of daily episodes, Visual Analogue Scale (VAS) during episodes, duration of episodes, and Raynaud Condition Score).

Materials and methods

Observational, descriptive, retrospective study of patients with RP who received ultrasound-guided interdigital injection of type A BT. Data from post-procedure controls (months 1, 3, and 6) were obtained, and analysis was performed using the Wilcoxon test through the StatPlus programme.

Results

The study was conducted on 8 patients (100% female) with a mean age of 48.5 years, all of whom had RP secondary to a systemic disease (87.5% systemic sclerosis). Significant differences were observed (median and interquartile range) in the number of RP episodes in the first month (P: .043). The pain VAS for each episode decreased in the first month (P: .027) and in the third month (P: .043). Differences were found in the Raynaud condition score in the first month (P: .027) and the third month (P: .043).

Conclusions

Ultrasound-guided interdigital injection of type A BT could be an adjuvant treatment for patients with RP.

雷诺氏现象（RP）是一种血管痉挛性疾病，引起疼痛和残疾。当常规治疗不足够有效时，需要探索其他治疗方案，如指间肉毒杆菌毒素（BT）注射。目的探讨RP患者的临床改善情况（每日发作次数、发作期间视觉模拟评分（VAS）、发作持续时间和雷诺病情评分）。材料和方法对接受超声引导下指间注射A型BT的RP患者进行观察性、描述性、回顾性研究，获得术后对照（1、3和6个月）数据，并通过StatPlus程序使用Wilcoxon检验进行分析。结果8例患者（100%为女性），平均年龄48.5岁，均为继发于全身性疾病的RP（87.5%为系统性硬化症）。观察到第一个月RP发作次数的显著差异（中位数和四分位数范围）（P: 0.043）。每次发作的疼痛VAS在第一个月（P: 0.027）和第三个月（P: 0.043）下降。治疗后第1个月和第3个月雷诺症状评分差异有统计学意义（P: 0.027）。结论超声引导下指间注射A型BT可作为RP患者的辅助治疗方法。

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引用次数: 0

Eosinophilic fasciitis associated with IgG4-related disease 嗜酸性筋膜炎与igg4相关疾病相关

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-07-01 Epub Date: 2025-07-18 DOI: 10.1016/j.rcreue.2025.06.010

Jesica Gallo , Alejandro Varizat , Sergio Paira

A 52-year-old male presented with pain and induration of the skin and muscles. Physical examination revealed swelling and induration of the skin and muscles of the arms, forearms, hands, thorax, abdomen, and legs, accompanied by the characteristic orange peel appearance. In addition to bilateral hearing impairment, there was enlargement of both lacrimal glands. Laboratory results revealed hyper-eosinophilia, elevated C-reactive protein, and erythrocyte sedimentation rate, hypocomplementaemia, polyclonal hypergammaglobulinaemia, elevated IgE, IgG, and increased IgG1 and IgG4. MRI of the lower limbs reported enhanced contrast in the muscles of both thighs with thickening of the semimembranosus vastus lateralis fascia and arms. A skin and fascia biopsy indicated lymphoplasmacytic infiltrate, eosinophils, and non-storiform fibrosis. Immunohistochemistry showed IgG4 positivity in less than 10%, with an IgG4/lgG range of less than 40%. The patient meets the criteria for eosinophilic fasciitis and ACR/EULAR criteria for IgG4-RD. For this reason, we would like to report the first case found of eosinophilic fasciitis associated with IgG4-RD.

一名52岁男性，表现为皮肤和肌肉疼痛和硬化。体格检查发现手臂、前臂、手部、胸部、腹部和腿部皮肤和肌肉肿胀和硬化，并伴有特征性橙皮样外观。除双侧听力障碍外，双侧泪腺肿大。实验室结果显示嗜酸性粒细胞增多、c反应蛋白升高、红细胞沉降率升高、补体不足、多克隆高γ球蛋白血症、IgE、IgG升高、IgG1和IgG4升高。下肢MRI显示双大腿肌肉造影剂增强，股外侧半膜肌筋膜增厚。皮肤和筋膜活检显示淋巴浆细胞浸润、嗜酸性粒细胞和非层状纤维化。免疫组化显示IgG4阳性小于10%，IgG4/lgG范围小于40%。患者符合嗜酸性筋膜炎的标准和IgG4-RD的ACR/EULAR标准。因此，我们报告第一例发现的与IgG4-RD相关的嗜酸性筋膜炎。

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引用次数: 0

Nailfold capillaroscopy. Where are we going? 甲襞capillaroscopy。我们要去哪里？

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-07-01 Epub Date: 2025-06-12 DOI: 10.1016/j.rcreue.2025.05.001

Luis Fernando Medina Quintero

引用次数: 0

Prevalence of comorbidities and use of medication in psoriatic arthritis patients: findings from a Mexican cohort 银屑病关节炎患者合并症的患病率和药物的使用：来自墨西哥队列的研究结果

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-07-01 Epub Date: 2025-07-18 DOI: 10.1016/j.rcreue.2025.06.005

David Vega-Morales , Alejandro Garza-Alpirez , María Fernanda Martínez-Guerra , Alondra Elizabeth Montoya-Montes

Introduction

Comorbidities contribute to the development of PsA and worsen disease severity. The aim of the study is to describe the clinical characteristics of Mexican PsA patients focusing on comorbidities and medications. The primary objective of our study was to investigate the clinical and epidemiological characteristics of patients with Psoriatic Arthritis (APs) who were undergoing treatment with biological disease-modifying antirheumatic drugs (bDMARDs).

Materials and methods

We conducted a cross-sectional observational study in a secondary care clinic in northern Mexico.

Results

Of the total sample, 38/66 (57.5%) were women, with a mean age of 47.8 (SD 11.5) years, a mean weight of 83.8 (SD 19) kg, and BMI of 31.5 (SD 6.5) kg/m2. Smoking and alcoholism were reported in 10/66 (15.1%) and 2 (3%) of patients, respectively.

Obesity occurred in 41 (62.1%) patients, followed by diabetes mellitus in 23 (34.8%) patients, and systemic arterial hypertension in 19 (28.7%) patients. Ischaemic heart disease, heart failure, and cancer were not present in any of the patients.

Conclusions

0ur study revealed a higher prevalence of chronic metabolic diseases among patients with psoriatic arthritis (PsA) compared to other cohorts without inflammatory arthropathy and the Mexican population.

合并症有助于PsA的发展，并加重疾病的严重程度。该研究的目的是描述墨西哥PsA患者的临床特征，重点关注合并症和药物治疗。本研究的主要目的是调查银屑病关节炎（APs）患者的临床和流行病学特征，这些患者正在接受生物疾病缓解抗风湿药物（bDMARDs）的治疗。材料和方法我们在墨西哥北部的一家二级保健诊所进行了一项横断面观察研究。结果女性占38/66(57.5%)，平均年龄47.8 （SD 11.5）岁，平均体重83.8 (SD 19) kg, BMI 31.5 (SD 6.5) kg/m2。吸烟和酗酒分别占10/66（15.1%）和2（3%）。肥胖41例（62.1%），糖尿病23例（34.8%），全身性动脉高血压19例（28.7%）。所有患者均未出现缺血性心脏病、心力衰竭和癌症。结论：我们的研究显示，银屑病关节炎（PsA）患者的慢性代谢性疾病患病率高于其他无炎性关节病的队列和墨西哥人群。

{"title":"Prevalence of comorbidities and use of medication in psoriatic arthritis patients: findings from a Mexican cohort","authors":"David Vega-Morales , Alejandro Garza-Alpirez , María Fernanda Martínez-Guerra , Alondra Elizabeth Montoya-Montes","doi":"10.1016/j.rcreue.2025.06.005","DOIUrl":"10.1016/j.rcreue.2025.06.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Comorbidities contribute to the development of PsA and worsen disease severity. The aim of the study is to describe the clinical characteristics of Mexican PsA patients focusing on comorbidities and medications. The primary objective of our study was to investigate the clinical and epidemiological characteristics of patients with Psoriatic Arthritis (APs) who were undergoing treatment with biological disease-modifying antirheumatic drugs (bDMARDs).</div></div><div><h3>Materials and methods</h3><div>We conducted a cross-sectional observational study in a secondary care clinic in northern Mexico.</div></div><div><h3>Results</h3><div>Of the total sample, 38/66 (57.5%) were women, with a mean age of 47.8 (SD 11.5) years, a mean weight of 83.8 (SD 19) kg, and BMI of 31.5 (SD 6.5) kg/m2. Smoking and alcoholism were reported in 10/66 (15.1%) and 2 (3%) of patients, respectively.</div><div>Obesity occurred in 41 (62.1%) patients, followed by diabetes mellitus in 23 (34.8%) patients, and systemic arterial hypertension in 19 (28.7%) patients. Ischaemic heart disease, heart failure, and cancer were not present in any of the patients.</div></div><div><h3>Conclusions</h3><div>0ur study revealed a higher prevalence of chronic metabolic diseases among patients with psoriatic arthritis (PsA) compared to other cohorts without inflammatory arthropathy and the Mexican population.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 3","pages":"Pages 216-221"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From immunosuppression to autoimmunity: PR3 ANCA-associated vasculitis in a patient immunosuppressed for hepatic transplant. A case report 从免疫抑制到自身免疫：肝移植免疫抑制患者的PR3 anca相关血管炎病例报告

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-07-01 Epub Date: 2025-06-17 DOI: 10.1016/j.rcreue.2025.04.001

Oscar Vicente Vergara Serpa , Carlos Jaime Velásquez , Luis Fernando Pinto , Neil Smith Pertuz Charris , Andrés Felipe Echeverri García , Alejandro Cardona Palacio , Javier Darío Márquez Hernández

Objective

To present the case of an immunosuppressed patient who developed an autoimmune disease.

Patients and methods

30-year-old woman, immunosuppressed, due to a history of orthotopic liver transplant, who developed intestinal infection by Cytomegalovirus and alveolar haemorrhage.

Results

Patient presented a positive serological finding for PR3 ANCA, classified as granulomatosis with polyangiitis. Due to her history, induction, and maintenance with an anti-CD20 were considered, with no further relapse over 6-month follow-up.

Conclusion

Immunosuppressed patients have risk factors for developing autoimmune diseases.

目的报告一例免疫抑制患者发展为自身免疫性疾病。患者和方法：30岁女性，因原位肝移植史，免疫抑制，发生巨细胞病毒肠道感染和肺泡出血。结果患者PR3 ANCA血清学阳性，归类为肉芽肿合并多血管炎。由于她的病史，我们考虑了诱导和抗cd20维持，在6个月的随访中没有进一步复发。结论免疫抑制患者存在发生自身免疫性疾病的危险因素。

引用次数: 0

Cutaneous spectrum of lupus erythematosus: A cohort of patients from a referral-center in Colombia 红斑狼疮的皮肤谱：来自哥伦比亚转诊中心的一组患者

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-07-01 Epub Date: 2025-07-18 DOI: 10.1016/j.rcreue.2025.06.007

Verónica Noguera-Castro , Claudia-Lorena Cano-Cuadros , Mariana Botero-Varón , Daniela Marín-Acevedo , Omar-Javier Calixto , Juan-Manuel Bello-Gualtero , Consuelo Romero-Sánchez

Introduction

To date, few epidemiological studies compare the incidence and prevalence of systemic lupus erythematosus (SLE) and isolated cutaneous lupus erythematosus (CLE). The information is even more scarce in Latin America. The aim of this study is to describe the phenotype of CLE in a reference center in Colombia.

Materials and methods

A retrospective cross-sectional study was carried out. SLE was confirmed according to EULAR/ACR 2019 classification criteria and patients were simultaneously evaluated in the rheumatology and dermatology clinics. A descriptive and bivariate analysis was carried out. The institutional committee approved the study.

Results

Thirty participants were diagnosed with SLE and CLE. Most patients were female (83.3%), with a mean age of 37 ± 13 years. Chronic CLE was the most prevalent subtype (46.7%), followed by acute (30%) and subacute (16.7%) CLE. There were statistically significant differences when comparing acute CLE and reduced C4 (p = .032); in subacute CLE and interstitial lung disease (p = .010); and in lymphopenia (p = .012) and thrombocytopenia (p = .046). Finally, there was a difference in patients with chronic CLE and the use of topical corticosteroid (p = .026), methotrexate (p = .036), and SLEDAI > 3 points (p = .025).

Conclusion

This study provides valuable insights into the phenotypic characteristics and associations of CLE with systemic manifestations in the Colombian population, contributing to the understanding and managing of this complex autoimmune disease.

迄今为止，很少有流行病学研究比较系统性红斑狼疮（SLE）和孤立性皮肤红斑狼疮（CLE）的发病率和患病率。在拉丁美洲，这方面的信息更少。本研究的目的是描述在哥伦比亚参考中心CLE的表型。材料与方法采用回顾性横断面研究。根据EULAR/ACR 2019分类标准确诊SLE，同时在风湿病和皮肤病学诊所对患者进行评估。进行了描述性和双变量分析。机构委员会批准了这项研究。结果30例被诊断为SLE和CLE。患者以女性为主（83.3%），平均年龄37±13岁。慢性CLE最常见（46.7%），其次是急性（30%）和亚急性（16.7%）CLE。急性CLE与减少C4比较，差异有统计学意义（p = 0.032）；亚急性CLE和间质性肺疾病（p = 0.010）；淋巴细胞减少（p = 0.012）和血小板减少（p = 0.046）。最后，慢性CLE患者与外用皮质类固醇（p = 0.026）、甲氨蝶呤（p = 0.036）和SLEDAI的使用存在差异；3分（p = 0.025）。结论：本研究为哥伦比亚人群中CLE的表型特征和与全身性表现的关联提供了有价值的见解，有助于理解和管理这种复杂的自身免疫性疾病。

{"title":"Cutaneous spectrum of lupus erythematosus: A cohort of patients from a referral-center in Colombia","authors":"Verónica Noguera-Castro , Claudia-Lorena Cano-Cuadros , Mariana Botero-Varón , Daniela Marín-Acevedo , Omar-Javier Calixto , Juan-Manuel Bello-Gualtero , Consuelo Romero-Sánchez","doi":"10.1016/j.rcreue.2025.06.007","DOIUrl":"10.1016/j.rcreue.2025.06.007","url":null,"abstract":"<div><h3>Introduction</h3><div>To date, few epidemiological studies compare the incidence and prevalence of systemic lupus erythematosus (SLE) and isolated cutaneous lupus erythematosus (CLE). The information is even more scarce in Latin America. The aim of this study is to describe the phenotype of CLE in a reference center in Colombia.</div></div><div><h3>Materials and methods</h3><div>A retrospective cross-sectional study was carried out. SLE was confirmed according to EULAR/ACR 2019 classification criteria and patients were simultaneously evaluated in the rheumatology and dermatology clinics. A descriptive and bivariate analysis was carried out. The institutional committee approved the study.</div></div><div><h3>Results</h3><div>Thirty participants were diagnosed with SLE and CLE. Most patients were female (83.3%), with a mean age of 37±13 years. Chronic CLE was the most prevalent subtype (46.7%), followed by acute (30%) and subacute (16.7%) CLE. There were statistically significant differences when comparing acute CLE and reduced C4 (<em>p</em>  =.010); and in lymphopenia (<em>p</em>  =.046). Finally, there was a difference in patients with chronic CLE and the use of topical corticosteroid (<em>p</em>  =.036), and SLEDAI>3 points (<em>p</em>  <!-->.025).</div></div><div><h3>Conclusion</h3><div>This study provides valuable insights into the phenotypic characteristics and associations of CLE with systemic manifestations in the Colombian population, contributing to the understanding and managing of this complex autoimmune disease.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 3","pages":"Pages 231-235"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

History of 50 years of the Rheumatology Service of Universidad Nacional de Colombia: The first in Colombia and a pioneer in Latin America 哥伦比亚国立大学风湿病服务部50年的历史：哥伦比亚第一，拉丁美洲先驱

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-07-01 Epub Date: 2025-07-18 DOI: 10.1016/j.rcreue.2025.06.009

Yimy F. Medina, Antonio Iglesias Gamarra

Introduction

The Rheumatology Unit of the National University of Colombia (UNAL) has a history spanning over half a century, producing many prominent rheumatologists. This article provides a description of its history to understand its trajectory, historical context, challenges, achievements, and contributions.

Reflections

In 1960, the Rheumatology Section at UNAL was officially approved, founded by professors Mario Peña, Humberto Lizarazo, and Fernando Chalem. In 1962, Drs. Peña, Chalem, and Lizarazo established the Rheumatology Service at San Juan de Dios Hospital. In 1963, the outpatient clinic for rheumatic patients began operating at the same hospital. Dr. Enrique Clavijo Acero became the first rheumatologist qualified through a Colombian university in 1971. By 1973, various specialty programmes at UNAL, including rheumatology, were officially approved, and the Rheumatology Unit was elevated to the status of a section.

Discussion

For more than 50 years, the Rheumatology Unit has trained medical students and specialists, who have played a critical role in the field. It remains a vital part of rheumatology both in Colombia and the region.

Conclusion

The Rheumatology Unit at the National University of Colombia, as the first academic institution in this field within the country, celebrates over 60 years of activity and 50 years of official recognition. It has achieved numerous milestones and has been a pioneering force in rheumatology.

哥伦比亚国立大学风湿病科（UNAL）有半个多世纪的历史，培养了许多杰出的风湿病学家。本文提供了对其历史的描述，以了解其发展轨迹、历史背景、挑战、成就和贡献。1960年，由Mario Peña、Humberto Lizarazo和Fernando Chalem教授成立的UNAL风湿病科正式批准成立。1962年。Peña， Chalem和Lizarazo在San Juan de Dios医院建立了风湿病服务中心。1963年，风湿病门诊在同一家医院开始营业。Enrique Clavijo Acero博士于1971年成为第一位通过哥伦比亚大学获得资格的风湿病学家。到1973年，UNAL的各种专业项目，包括风湿病学，得到正式批准，风湿病学股被提升到一个科的地位。讨论50多年来，风湿病科培养了医学学生和专家，他们在该领域发挥了关键作用。它仍然是哥伦比亚和该地区风湿病学的重要组成部分。哥伦比亚国立大学的风湿病学单位，作为国内该领域的第一个学术机构，庆祝了60多年的活动和50年的官方认可。它已经取得了许多里程碑，并已成为风湿病学的先驱力量。

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引用次数: 0

Nailfold capillaroscopy in mixed connective tissue disease, systemic sclerosis, and primary Raynaud phenomenon in a capillaroscopy service from Medellin, Colombia 2015–2020 2015-2020年哥伦比亚麦德林市的一项毛细血管镜检查服务中，甲襞毛细血管镜检查混合性结缔组织病、系统性硬化症和原发性雷诺现象

Revista Colombiana de Reumatología (English Edition)

Pub Date : 2025-07-01 Epub Date: 2025-04-15 DOI: 10.1016/j.rcreue.2025.03.004

Adriana Margarita Trejos Tenorio , Carlos Jaime Velásquez Franco , Libia María Rodríguez Padilla , Miguel Antonio Mesa Navas

Introduction

Nailfold capillaroscopy is a useful tool to evaluate microcirculation. In mixed connective tissue disease (MCTD), microvascular changes are not clearly defined. This study aims to compare the angiographic findings between patients with mixed connective tissue disease, systemic sclerosis, and primary Raynaud phenomenon (pRP) in a capillaroscopy reference centre.

Methods

A retrospective descriptive study with an exploratory analytical component was designed. Clinical and capillaroscopic characteristic information was obtained from medical records and capillaroscopic reports from an expert capillaroscopy service using an Optilia 200x videocapillaroscope. To compare qualitative variables, the Pearson or Fisher exact chi-square test was used in case of expected frequencies lower than five.

Results

One hundred and twenty capillaroscopy charts were reviewed. In the MCTD group, 42.5% of patients showed a normal pattern, 37.5% had a non-scleroderma pattern, and 20% exhibited a scleroderma pattern. Among pRP patients, 62.5% had a normal and 37.5% had a non-specific pattern; both groups preserved capillary density. In MCTS, compared to SS, there were fewer avascular areas (10% vs. 62.5% p < .001), megacapillaries (20% vs 100%, p < .001), and haemorrhages (37.5 vs. 92.5% p < .001). Bushy capillaries predominated in the MCTD (10%) compared to SS (5%) and pRP (0%) groups without significance difference (p = .122).

Conclusions

Compared to systemic sclerosis, mixed connective tissue disease presents greater capillary density and a greater frequency of arborescent capillaries.

甲襞毛细血管镜是评估微循环的有效工具。在混合性结缔组织病（MCTD）中，微血管的改变没有明确的定义。本研究旨在比较混合结缔组织病、系统性硬化症和原发性雷诺现象（pRP）患者在毛细血管镜参考中心的血管造影结果。方法设计回顾性描述性研究，并结合探索性分析成分。临床和毛细血管检查特征信息来自医疗记录和专家毛细血管检查服务报告，使用Optilia 200x视频毛细血管镜。为了比较定性变量，在预期频率低于5的情况下，使用Pearson或Fisher精确卡方检验。结果回顾了120张毛细血管镜检查图。在MCTD组中，42.5%的患者表现为正常模式，37.5%的患者表现为非硬皮病模式，20%表现为硬皮病模式。pRP患者中62.5%为正常型，37.5%为非特异性型；两组均保持了毛细血管密度。在MCTS中，与SS相比，无血管区域（10% vs. 62.5% p <； .001）、巨毛细血管（20% vs. 100% p <； .001）和出血（37.5 vs. 92.5% p <； .001）较少。与SS组（5%）和pRP组（0%）相比，MCTD组（10%）以浓密毛细血管为主，但无显著性差异（p = .122）。结论与系统性硬化症相比，混合性结缔组织病毛细血管密度大，树形毛细血管出现频率高。

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引用次数: 0