Revista Colombiana de Reumatología (English Edition)最新文献

{"title":"Correlation of simple hematological parameters with disease activity and damage indices among Egyptian patients with systemic lupus erythematosus","authors":"Hanan H. Ahmed ,&nbsp;Hebatallah S. Farag ,&nbsp;Nesreen Sobhy","doi":"10.1016/j.rcreue.2025.04.003","DOIUrl":"10.1016/j.rcreue.2025.04.003","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the correlation of different hematological parameters in lupus patients with SLE disease activity index (SLEDAI), the Systemic Lupus International Collaboration Clinics/American College of Rheumatology Damage Index (SLICC/ACR DI), and some laboratory data related to kidney functions in active patients with nephritis.</div></div><div><h3>Material and methods</h3><div>80 inactive SLE patients (SLEDAI score<!--> <!-->&lt;<!--> <!-->10 points), and 80 active patients (SLEDAI<!--> <!-->≥<!--> <!-->10 points) were enrolled in this study. All patients underwent full medical history taking, clinical evaluation including calculation of SLEDAI and SLICC/ACR DI scores, and laboratory investigations including complete blood count. The two groups were compared regarding different disease parameters. Correlations of some hematological parameters with SLEDAI, SLICC/ACR DI scores and some laboratory data related to kidney function in patients with nephritis were made.</div></div><div><h3>Results</h3><div>The active group showed statistically significantly higher mean NLR (<em>P</em> <!-->=<!--> <!-->0.000), NC3R (<em>P</em> <!-->=<!--> <!-->0.000), MLR (<em>P</em> <!-->=<!--> <!-->0.000), PLR (<em>P</em> <!-->=<!--> <!-->0.000), and RDW (<em>P</em> <!-->=<!--> <!-->0.001), and statistically significantly lower mean MPV (<em>P</em> <!-->=<!--> <!-->0.002). The mean MLR (<em>P</em> <!-->=<!--> <!-->0.018) and PLR (<em>P</em> <!-->=<!--> <!-->0.005) were statistically significantly higher in the active patients with nephritis. For both groups, there were no significant correlations between studied parameters and SLEDAI or SLICC/ACR DI, except with NC3R values in the active group which were associated with SLEDAI (<em>r</em> <!-->=<!--> <!-->.221, <em>P</em> <!-->=<!--> <!-->0.049).</div></div><div><h3>Conclusion</h3><div>The hematological parameters in SLE have promising potential clinical application as a novel activity marker, especially in patients with nephritis.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 2","pages":"Pages 145-151"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ABC of lupus nephritis","authors":"José A. Gómez-Puerta","doi":"10.1016/j.rcreue.2025.03.003","DOIUrl":"10.1016/j.rcreue.2025.03.003","url":null,"abstract":"","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 2","pages":"Pages 103-104"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic, clinical, and biochemical characteristics of patients who presented with and without lupus nephritis in a cohort of Mexican patients with systemic lupus erythematosus in a referral centre","authors":"Fabiola Pazos-Pérez ,&nbsp;Aida Martínez-Badajoz ,&nbsp;Francisco M. Bravo-Rojas ,&nbsp;Estafanía Garduño-Hernández ,&nbsp;María I. Gil-Arredondo ,&nbsp;Rocío Catana-Hernández ,&nbsp;Mario C. Ocampo-Torres ,&nbsp;Juan C. Hernández-Rivera","doi":"10.1016/j.rcreue.2025.02.005","DOIUrl":"10.1016/j.rcreue.2025.02.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease that presents great clinical heterogeneity, so that up to 60% of patients may develop lupus nephropathy (LN).</div></div><div><h3>Objective</h3><div>To identify demographic, clinical, and biochemical characteristics of patients presenting with and without lupus nephritis at the time of SLE diagnosis in a cohort of Mexican patients</div></div><div><h3>Materials and methods</h3><div>This is a cross-sectional, analytical, and single-centre study. Frequencies and percentages were used for categorical variables and the comparison was made with Pearson's Chi2 statistical test or Fisher's exact test. For the quantitative variables, their distribution was calculated and according to this, Student's t was used in case of normal distribution and Mann-Whitney U for those with free distribution.</div></div><div><h3>Results</h3><div>Of 160 patients, 79 (49.37%) had LN. These individuals had a higher prevalence of serositis (14.3 vs. 8.1%, p = 0.048) and arterial hypertension (40.50% vs. 24.6%, p = 0.033), while those without LN had a higher prevalence of rheumatoid arthritis and joint disease (6 vs. 1%, p = 0.052), allergies (43.2 vs. 20.25%, p = 0.002), infections (23.45 vs. 10%, p = 0.020), and lower levels of C3 (52.25±28.7 vs. 74.6±32.2 mg/dl, p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The characteristics described in our cohort are like those presented in other Latino and Asian series. However, the presence of concomitant infections at the time of SLE diagnosis has not been described and should be considered for future research.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 2","pages":"Pages 110-117"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of induction therapy with mycophenolate or cyclophosphamide on serum BAFF levels in patients with systemic lupus erythematosus","authors":"Alejandra Betancur Herrera ,&nbsp;Juan José Mariño Restrepo ,&nbsp;Tulio Lopera Restrepo ,&nbsp;Laura Robledo Montoya ,&nbsp;Juan Felipe Soto Restrepo ,&nbsp;Adriana Lucía Vanegas García ,&nbsp;Carlos Horacio Muñoz Vahos ,&nbsp;Juan Camilo Díaz Coronado ,&nbsp;Ricardo Antonio Pineda Tamayo ,&nbsp;Gloria Vásquez","doi":"10.1016/j.rcreue.2024.12.002","DOIUrl":"10.1016/j.rcreue.2024.12.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which B cell hyperactivity plays a key role in its pathophysiology. In this disease, the B cell activating factor (BAFF) is implicated in the loss of immunological tolerance, and high concentrations of this factor have been linked to disease progression. It is unknown how induction therapies with cyclophosphamide (CFM) or mycophenolate (MMF) modulate BAFF levels.</div></div><div><h3>Objective</h3><div>To determine how induction therapies modulate BAFF concentrations.</div></div><div><h3>Materials and methods</h3><div>An analytical observational study was performed with 20 patients with SLE from two institutions between 2020–2022, clinical and laboratory information was obtained from medical records. Measurement of serum BAFF levels was performed using an ELISA kit and statistical analyses with GraphPad Prism version 9.</div></div><div><h3>Results</h3><div>20 patients with a diagnosis of SLE, 18 with CFM and 2 with MMF, were included, nine patients at baseline and eleven at 3–6 months. The median BAFF in SLE patients was 902.2 pg/mL and 379.7 pg/mL in healthy controls, statistically significant differences (p = .0003). BAFF levels were also found to be different among patients treated with antimalarials (p = .0465) and an inverse correlation with creatinine values and prednisolone doses was also observed.</div></div><div><h3>Conclusions</h3><div>BAFF levels are affected during induction therapy, observing an initial reduction and subsequent recovery at 3–6 months, our results suggest that chloroquine and high doses of prednisolone maintain lower serum BAFF levels.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 2","pages":"Pages 118-129"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with development of end stage renal disease during hospitalization in patients with microscopic polyangiitis and granulomatosis with polyangiitis in a population of northwestern Colombia","authors":"Santiago Cobaleda Cano ,&nbsp;Andrés Felipe Echeverri García ,&nbsp;Adriana Margarita Trejos Tenorio ,&nbsp;Javier Darío Márquez Hernández ,&nbsp;Jhon Edwar García Rueda ,&nbsp;Luis Fernando Pinto Peñaranda","doi":"10.1016/j.rcreue.2024.12.001","DOIUrl":"10.1016/j.rcreue.2024.12.001","url":null,"abstract":"<div><h3>Introduction</h3><div>ANCA vasculitis has been associated with increased morbidity and mortality, high disease burden, and organ damage, especially renal.</div></div><div><h3>Objectives</h3><div>To determine factors associated with end-stage kidney disease at hospital discharge in microscopic polyangiitis and granulomatosis with polyangiitis patients, to characterize our population, hospitalization causes, treatment received, and complications during stay.</div></div><div><h3>Materials and methods</h3><div>Adults with previous or new diagnosis of microscopic polyangiitis and granulomatosis with polyangiitis who required hospitalization between January 01, 2013, and April 30, 2021, were included. Association with end-stage kidney disease development was evaluated by Pearson’s Chi² (<em>χ</em>²) or Fisher’s test, and Student’s <em>t</em> or Mann–Whitney <em>U</em> test according to the nature of the variables. Exploratory multivariate models were made including factors associated with end-stage kidney disease.</div></div><div><h3>Results</h3><div>Forty-three patients were included, microscopic polyangiitis 55.8, and granulomatosis with polyangiitis 44.25. Twelve patients (27.9%) developed early end-stage kidney disease. High blood pressure, high urea nitrogen levels on admission, as well as pulmonary oedema, and Five Factor Score &gt;1 entailed a higher risk. In contrast, normal kidney function on admission was a protective factor. Rapidly progressive glomerulonephritis and arterial hypertension on admission were associated with end-stage kidney disease. In adjusted exploratory models according to vasculitis type, Birmingham Vasculitis Activity Score, diffuse alveolar haemorrhage, and plasma exchange use were identified as factors to include in multivariate models in multicentre studies.</div></div><div><h3>Conclusion</h3><div>88% of patients had renal involvement and 27.9% developed end-stage kidney disease. Rapidly progressive glomerulonephritis and arterial hypertension on hospital admission were associated with early development of end-stage kidney disease while normal renal function on admission was a protective factor for this outcome.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 1","pages":"Pages 16-26"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erdheim-Chester disease, an uncommon non-Langerhans cell histiocytosis and its association with Sjögren's syndrome","authors":"Alejandra Espinosa Trujillo ,&nbsp;Francisco Brañas Fernández ,&nbsp;Aitor Abuín Blanco ,&nbsp;Robustiano Pego Reigosa ,&nbsp;María Rodríguez Rodríguez","doi":"10.1016/j.rcreue.2024.11.002","DOIUrl":"10.1016/j.rcreue.2024.11.002","url":null,"abstract":"<div><div>Erdheim Chester disease (ECD) is a rare non-Langerhans cell histiocytosis. It is characterized by the infiltration of various organs and tissues by foamy histiocytes with a heterogeneous clinical course that varies from mild forms to disseminated forms with progressive and lethal behaviour. The case of a patient who presented with a cerebellar syndrome associated with autoimmune pathology is presented. In the course of the disease, refractoriness to glucocorticoids and clinical manifestation with bone involvement in the form of symmetrical osteosclerosis of long bones were determining factors for suspicion of this entity. We reviewed scientific articles through the PubMed metasearch engine with the keywords “erdheim chester disease”, “erdheim chester and nervous system”, and “autoimmunity and erdheim chester disease”, selecting those with greater emphasis on clinical presentation with neurological involvement and associated autoimmune pathology. Advances in the pathogenesis of ECD have allowed us to understand the nature of the disease, as well as the use of targeted therapies. It is interesting to keep this entity in mind, as well as the pathologies with which it is frequently associated, with the objective of an early diagnosis and a better clinical approach.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 1","pages":"Pages 90-94"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies for organizing rheumatology consultations","authors":"Juan Fernando Rivadeneira Jácome,&nbsp;Lara Montserrat González García","doi":"10.1016/j.rcreue.2024.11.006","DOIUrl":"10.1016/j.rcreue.2024.11.006","url":null,"abstract":"<div><h3>Introduction</h3><div>The prevalence of rheumatic disease in the general population is approximately 10%. At the same time, there has been an increase in the workload of rheumatology services, particularly concerning consultations. Many health institutions have limited the duration of rheumatology consultation to about 15 min. This article demonstrates the need to lengthen the duration rheumatology consultations.</div></div><div><h3>Objective</h3><div>The goal of this work is to review the literature about the standards for the duration of rheumatology consultations and to propose new organizational strategies in this regard.</div></div><div><h3>Materials and methods</h3><div>A narrative review of the current literature related to care standards in rheumatology consultations was carried out, including the wide variety of diagnostic procedures, which decisively influence the duration of these consultations.</div></div><div><h3>Results and discussion</h3><div>Organizational strategies are proposed, based on classifying consultations into first, second, and follow-up visits, with a specific daily number, and giving more time to the first two types of consultations. Although this planning implies greater effort on the part of administrative staff, it will undoubtedly result in a better quality of care for rheumatology patients.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 1","pages":"Pages 84-89"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum interleukin-41 concentrations are decreased in women with rheumatoid arthritis and are not affected by menopausal status, disease activity, or medication","authors":"Dhuha F.N. Bani-Wais ,&nbsp;Ali H. Ad’hiah","doi":"10.1016/j.rcreue.2025.02.002","DOIUrl":"10.1016/j.rcreue.2025.02.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder characterized by immunobiological homeostasis. The recently discovered cytokine interleukin-41 (IL-41) is among the immunobiological components suggested to have modulatory effects in RA and has shown up-regulated levels in patients. However, IL-41 has not been explored during the pre- (PRM) and post-menopausal (POM) periods in women with RA, and its relationship to disease activity and medications has not been well studied.</div></div><div><h3>Materials and methods</h3><div>In this case–control study, serum IL-41 concentrations were quantified in 120 women with RA (70 PRM and 50 POM) and 110 control women using an enzyme-linked immunosorbent assay kit. Thirty patients were newly diagnosed (ND) and 90 patients were on treatment with etanercept (a tumor necrosis factor inhibitor; TNF) plus methotrexate (MD).</div></div><div><h3>Results</h3><div>Median IL-41 concentrations (interquartile range) were significantly lower in RA patients than in control women (49.8 [32.5–79.5] <em>vs</em>. 104.7 [76.9–134.6]<!--> <!-->pg/mL; probability &lt;.001). As indicated by the area under the curve, .827, IL-41 showed reliable discrimination between RA patients and HC. IL-41 concentrations stratified by menopausal status (PRM <em>vs</em>. POM), disease activity score 28 (&lt;3.2 <em>vs</em>. ≥3.2), and medication (ND <em>vs</em>. MD) showed no significant difference in each stratum.</div></div><div><h3>Conclusions</h3><div>In contrast to previous studies, serum IL-41 concentrations were significantly decreased in the present cohort of women with RA. These concentrations were not affected by menopausal status, disease activity, or medication. Data from the current study suggest that IL-41 is involved in the pathophysiology of RA.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 1","pages":"Pages 27-35"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic evidence of mepolizumab in eosinophilic granulomatosis with polyangiitis: A scoping review","authors":"Eduardo Tuta-Quintero ,&nbsp;Isabella Perna-Reyes ,&nbsp;Juan Olivella-Gómeza ,&nbsp;Daniela Rodríguez-Fraile ,&nbsp;Juan C. Santacruz ,&nbsp;Andrea A. Mayorga-Borja ,&nbsp;John Londoño","doi":"10.1016/j.rcreue.2024.11.008","DOIUrl":"10.1016/j.rcreue.2024.11.008","url":null,"abstract":"<div><div>Mepolizumab (MPZ) is a therapeutic option for eosinophilic granulomatosis with polyangiitis (EGPA). However, the evidence on its efficacy, effectiveness, and safety is limited. Our results included 17 full-text articles evaluating the use of MPZ in patients diagnosed with EGPA, 47% (8/17) of the documents were case reports, 18% (3/17) retrospective cohort studies, 12% (2/17) clinical trials, and 6% corresponded to a prospective cohort (1/17), ambispective cohort (1/17), case series (1/17), and pilot study (1/17). The most frequently used dose of MPZ was 300 mg/month, described in 59% (10/17) of the included manuscripts. The decrease in the Birmingham Vasculitis Activity Score, reduction in the dose of corticosteroids, and modulation in the number of eosinophils in the blood were the variables most used to determine the clinical effect in patients. Finally, 10 clinical trial records were included describing the design, conduct, and administration of the ongoing studies. The use of MPZ in patients with EGPA shows a reduction in the Birmingham Vasculitis Activity Score, saving oral corticosteroids and modulating blood hypereosinophilia. The adverse events described were mild and moderate in all the included studies.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 1","pages":"Pages 69-83"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus for risk management in the prescription of biologic therapies or targeted synthetic antirheumatic drugs: Colombian Association of Rheumatology 2023","authors":"Elías Gonzalo Forero Illera ,&nbsp;Andrés Ricardo Fernández Aldana ,&nbsp;Daniel Gerardo Fernández Ávila ,&nbsp;Edwin Antonio Jáuregui Cuartas ,&nbsp;Gloria Vásquez ,&nbsp;Monique Chalem ,&nbsp;Wilson Bautista Molano","doi":"10.1016/j.rcreue.2024.11.005","DOIUrl":"10.1016/j.rcreue.2024.11.005","url":null,"abstract":"","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 1","pages":"Pages 56-68"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}