Background and objective:
The prevalence of myopia is increasing globally, with projections suggesting that by 2050, half of the population could be affected and 10% may experience high myopia. High myopia significantly increases the risk of irreversible vision loss due to complications such as myopic macular degeneration, retinal detachment, and glaucoma. Early detection in childhood is therefore crucial to implement timely interventions and prevent progression. However, identifying myopia in clinical practice remains challenging, as current methods often rely on subjective recall or require specialized tests that may not be widely available. This highlights the need for faster, more accessible, and reliable detection methods. Artificial intelligence, particularly deep learning, offers a promising alternative for quickly and accurately identifying myopia in children. This study presents the first application of deep learning methods to predict myopia in children.
Methods:
We conducted a comprehensive analysis of different families of deep learning architectures – namely convolutional neural networks, transformers, and state-based models – along with training strategies including Low-Rank Adaptation (LoRA) and full fine-tuning. These models were trained to predict spherical equivalent from retinal fundus images of children.
Results:
Our experiments demonstrated that transformer- and state-based architectures outperformed convolutional models. Additionally, full fine-tuning yielded better results compared to LoRA, although the latter is more resource-efficient. The best-performing model, based on the Mamba architecture, achieved a mean absolute error (MAE) of 0.74 diopters in estimating spherical equivalent, a similar result to those obtained in the literature for adult cohorts.
Conclusions:
Deep learning models, particularly those based on transformer and Mamba architectures, show strong potential for predicting myopia in children using retinal fundus images. These findings are a step towards the development of scalable and accessible tools for early myopia detection and intervention.
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