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Red cell distribution width as a marker of thyroid papillary carcinoma 红细胞分布宽度作为甲状腺乳头状癌的标志
Pub Date : 2016-04-01 DOI: 10.4103/2468-5585.185198
B. Sevinç, O. Karahan, S. Ay, N. Aksoy, A. Okuş
Aim: The study aims to evaluate the relation between red cell distribution width (RDW) and papillary thyroid carcinoma. RDW is a part of routine complete blood count which shows the heterogeneity of the circulating red cells. Studies showed that RDW increases in inflammatory disorders. Methods: The patients′ data from 100 cases with total thyroidectomy were retrospectively evaluated. A total of 50 cases with thyroid papillary carcinoma and 50 cases with benign thyroid nodule were included into the evaluation. Results: The mean RDW value was 14.5 ± 1.7 in papillary carcinoma group and 13.4 ± 0.8 in benign thyroid nodule group. Other hematological parameters of the groups were similar. According to the receiver operating characteristic (ROC) curve, the optimal RDW value for thyroid papillary carcinoma was found to be 12.95% with a sensitivity of 88.00% and specificity of 70.00% (the area under an ROC curve: 0.718, P < 0.001). Conclusion: There is no study in literature evaluating the relation between RDW value and papillary thyroid carcinoma. According to the recent study, an increase in RDW value can be a helping parameter in differentiating papillary carcinoma from benign thyroid nodule.
目的:探讨红细胞分布宽度(RDW)与甲状腺乳头状癌的关系。RDW是常规全血细胞计数的一部分,显示循环红细胞的异质性。研究表明,RDW在炎症性疾病中增加。方法:对100例甲状腺全切除术患者资料进行回顾性分析。50例甲状腺乳头状癌和50例良性甲状腺结节纳入评估。结果:甲状腺乳头状癌组的平均RDW值为14.5±1.7,甲状腺良性结节组的平均RDW值为13.4±0.8。两组其他血液学指标相似。根据受试者工作特征(ROC)曲线,发现甲状腺乳头状癌的最佳RDW值为12.95%,灵敏度为88.00%,特异性为70.00% (ROC曲线下面积为0.718,P < 0.001)。结论:目前尚无文献评价RDW值与甲状腺乳头状癌的关系。根据最近的研究,RDW值的升高可以作为鉴别甲状腺乳头状癌与良性结节的一个辅助参数。
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引用次数: 3
Nonleukemic myeloid sarcoma presenting as intussusception of small bowel in a male patient: An unusual presentation 非白血病骨髓肉瘤表现为小肠肠套叠的男性患者:一个不寻常的表现
Pub Date : 2016-04-01 DOI: 10.4103/2468-5585.185200
S. Ocak, H. Alakus, M. Duymus, M. Kaya, K. Karadayi, Neşe Yeldir, H. Ozer, E. Colak
Myeloid sarcoma (MS) is an extramedullary tumor of the myeloid cells and usually develops in lymphoid organs, bones, skin, adipose tissue, and the central nervous system. Gastrointestinal or isolated mesenteric involvement is an extremely rare without bone marrow (BM) involvement. Only a few cases had reported before. In this paper, we report a case of a 37-year-old male who presented with small bowel intussusception due to mesenteric MS. Abdominal computed tomography findings revealed intussusception of the small bowel in the left lower quadrant of the abdomen and mesenteric masses. The patient underwent operation, and masses were excised with segmental small bowel and segmental colon resection because the masses were adjacent to the bowel wall. Histopathology and immunohistochemistry showed MS in mesentery. Patient received 2 cycles of cytosine arabinoside combined with idarubicin chemotherapy in the postoperative period and was doing well at 6 months of follow-up. MS in mesentery presenting as intussusception of small bowel without BM involvement is very rare and it should be considered in the differential diagnosis of intestinal obstruction.
髓系肉瘤(MS)是髓系细胞的髓外肿瘤,通常发生在淋巴器官、骨骼、皮肤、脂肪组织和中枢神经系统。胃肠道或孤立的肠系膜受累是极其罕见的不累及骨髓。以前只有少数病例被报道过。在本文中,我们报告一位37岁男性,因肠系膜质谱而表现为小肠肠套叠。腹部电脑断层扫描显示腹部左下腹小肠肠套叠及肠系膜肿块。患者接受手术,因肿物靠近肠壁,采用节段性小肠和节段性结肠切除肿物。肠系膜组织病理及免疫组化示多发性硬化。术后患者接受2个周期的阿糖胞苷联合依达柔比星化疗,随访6个月,疗效良好。肠系膜多发性硬化表现为小肠肠套叠而不累及BM是非常罕见的,在肠梗阻的鉴别诊断中应予以考虑。
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引用次数: 1
Successful laparoscopic removal of ingested fork 腹腔镜下成功取出摄入的叉子
Pub Date : 2016-01-01 DOI: 10.4103/2468-5585.179565
Z. Demetrashvili, D. Loladze, Ketevan Vibliani, Tamar Metreveli
Most ingested foreign bodies (FBs) pass through the gastrointestinal tract without any problems, although their passage depends on shape and size. When a FB is relatively large, endoscopic removal may be utilized in most cases (the success rate was 95%), but sometimes surgery is required. We present a case report of a 27-year-old woman with epilepsy who had swallowed a fork in a suicide attempt. A plain abdominal radiograph confirmed a FB (fork) in the stomach with no visible pneumoperitoneum. On objective examination, the abdomen was soft and nontender with no peritoneal irritation. After a failed attempt at endoscopic removal, the laparoscopic intervention was undertaken. The operation was performed under general anesthesia utilizing open laparoscopy (Hasson's technique). As a result, the fork was successfully removed without further complications. After 72 h, she was discharged from the hospital without any complications. The patient was followed up after 4 weeks and made a full recovery.
大多数被摄入的异物(FBs)通过胃肠道没有任何问题,尽管它们的通过取决于形状和大小。当FB较大时,大多数情况下可采用内镜切除(成功率为95%),但有时需要手术。我们提出了一个27岁的癫痫妇女谁吞了一个叉子自杀企图的病例报告。腹部平片证实胃有FB(叉形),未见气腹。客观检查,腹部柔软无压痛,腹膜无刺激。在内镜切除失败后,进行了腹腔镜干预。手术在全麻下使用开放腹腔镜(Hasson技术)进行。结果,叉子被成功取出,没有进一步的并发症。72小时后,患者出院,无任何并发症。术后4周随访,患者完全康复。
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引用次数: 0
Nissen fundoplication in severely ill infants: A STROBE compliant study 重症婴儿的尼森底重复:一项符合STROBE的研究
Pub Date : 2016-01-01 DOI: 10.4103/2468-5585.179564
John Yoon, S. Burjonrappa
Aim: Anti-reflux surgery is offered to those who fail medical management for gastroesophageal reflux disease (GERD) in the pediatric population. A handful of studies show that those with neurologic impairment have benefited from these procedures; however, there are a few studies that document the indications and outcomes for infants < 6 months of age. Methods: A retrospective analysis of children < 6 months of age who underwent a Nissen fundoplication (NF) at St. Joseph's Regional Medical Center from December 2006 to June 2013 was performed. The following factors, such as surgical indications, comorbidities, hospital course data, weight gain, length of stay, and complications, were analyzed. Results: A total of 23 patients with the average age of 95.8 days were studied in this analysis. Presurgery, the average weight of these patients was 9.88 percentile (interquartile range: 5.85). A total of 65.2% patients were considered having failure to thrive (FTT) as they were under the 10th percentile and 78% patients had anatomic or genetic abnormalities. Nearly 47.8% patients underwent upper gastrointestinal studies that were positive for reflux. All patients had a concomitant gastrostomy tube (G-tube) placed during the NF. Diet was advanced on the average postoperative day of 2, and the patients tolerated the highest diet by the postoperative day of 6. Most patients saw a decrease in medications after the procedure. Moreover, 7 patients had complications related to the G-tube, with the main complication reported as leakage around the tube. There were two mortalities, both unrelated to the operation. Conclusion: Infants undergoing NF under the age of 6 months typically present with multiple comorbidities. NF in this population will not only lead to weight gain but also decrease in overall need for GERD-related medications. Early recognition of the failure of nasojejunal feeds will facilitate NF before significant FTT is present.
目的:抗反流手术是提供给那些医疗管理失败的胃食管反流病(GERD)的儿科人群。少数研究表明,那些有神经损伤的人从这些手术中受益;然而,有一些研究记录了6个月以下婴儿的适应症和结果。方法:回顾性分析2006年12月至2013年6月在圣约瑟夫地区医疗中心接受尼森底吻合(NF)手术的< 6月龄儿童。分析手术指征、合并症、病程、体重增加、住院时间和并发症等因素。结果:本分析共纳入23例患者,平均年龄95.8天。手术前,这些患者的平均体重为9.88百分位数(四分位数间距为5.85)。共有65.2%的患者被认为是生长失败(FTT),因为他们低于第10百分位数,78%的患者有解剖或遗传异常。近47.8%的患者接受了上胃肠道检查,反流呈阳性。所有患者在NF过程中同时放置胃造口管(g管)。术后平均第2天患者饮食提前,术后第6天患者饮食耐受最高。大多数患者在手术后减少了药物治疗。7例患者出现与g管相关的并发症,主要并发症为g管周围渗漏。有两人死亡,都与手术无关。结论:6个月以下接受NF的婴儿通常存在多种合并症。在这一人群中,NF不仅会导致体重增加,而且还会减少对反流相关药物的总体需求。在出现明显的FTT之前,早期识别鼻空肠喂养失败将促进NF。
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引用次数: 1
New frontiers in mini-invasive biliary surgery: Single incision laparoscopic surgery, natural orifice transluminal endoscopic surgery, and robotics 微创胆道手术的新领域:单切口腹腔镜手术、自然孔道腔内内镜手术和机器人技术
Pub Date : 2016-01-01 DOI: 10.4103/2468-5585.179562
G. Currò, G. Navarra
During the last 2 decades, technological advances as high-definition cameras along with three-dimensional vision systems, vessel sealing devices, and articulating instruments have added safety, efficacy, and precision to laparoscopic procedures. The need to develop even more minimally invasive surgical techniques has led laparoscopic surgeons to try to reduce the number of skin incisions or to avoid them altogether, and change the way to approach peritoneal cavity. Natural orifice transluminal endoscopic surgery and single incision laparoscopic surgery represent the surgeon's attempt to reduce invasiveness and body image trauma perception and improved esthetics in comparison with conventional laparoscopic surgery. All these innovations have been successfully applied to laparoscopic cholecystectomy. However, it is still debated when and how to use them instead of conventional procedures.
在过去的二十年中,技术的进步,如高清摄像机、三维视觉系统、血管密封装置和关节器械,增加了腹腔镜手术的安全性、有效性和准确性。由于需要开发更微创的手术技术,腹腔镜外科医生试图减少或完全避免皮肤切口的数量,并改变进入腹腔的方式。与传统腹腔镜手术相比,自然孔腔内窥镜手术和单切口腹腔镜手术代表了外科医生对减少侵入性和身体形象创伤感知以及改善美学的尝试。这些创新已成功应用于腹腔镜胆囊切除术。然而,何时以及如何使用它们来代替传统程序仍然存在争议。
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引用次数: 0
Effect of intensive statin therapy on coronary intervention outcomes, cardiac markers, vaspin, and adiponectin levels in elderly patients with coronary heart disease 强化他汀类药物治疗对老年冠心病患者冠状动脉介入治疗结果、心脏指标、血管素和脂联素水平的影响
Pub Date : 2016-01-01 DOI: 10.4103/2468-5585.179566
Yan Liang, Jun Guo, Zhe Zhang, Yang-Jie Li, Yuan Zhang
Aim: To explore the effect of intensive statin therapy (different doses) on percutaneous coronary intervention (PCI) outcomes in elderly patients with coronary heart disease (CHD). Methods: In this Institutional Ethics Committee-approved study, 105 elderly patients (> 80-year-old) with CHD admitted into the First Affiliated Hospital of Jinan University from June 2012 to June 2014 were randomly divided into three groups and received 20 mg/day, 40 mg/day, or 60 mg/day atorvastatin, respectively, before PCI surgery. Postsurgical (1 month after surgery) changes in major adverse cardiovascular events (MACEs), cardiac markers, vaspin, and adiponectin levels were compared among the groups. Results: Among the study groups, the incidence of MACE and PCI-related myocardial infarction rate was the lowest in 60 mg group (2.9%) reaching significance (P < 0.05). Although postsurgical cardiac marker levels increased significantly (P < 0.05), the values were found inversely correlated to statin dose (P < 0.05). Postsurgical vaspin, adiponectin, and alanine aminotransferase levels significantly increased in 60 mg group (P < 0.05). There was no considerable difference between presurgical and postsurgical serum creatinine and blood urea nitrogen levels in any group (P > 0.05). No study subjects showed statin-related myopathy. Conclusion: The application of 60 mg/d intensive statin therapy in short term could improve outcomes of PCI in patients with elderly CHD, maintain stable levels of cardiac markers, Vaspin and adiponectin, with exact effect and good safety.
目的:探讨不同剂量他汀类药物强化治疗对老年冠心病(CHD)患者经皮冠状动脉介入治疗(PCI)结局的影响。方法:本研究经机构伦理委员会批准,选取2012年6月至2014年6月济南大学第一附属医院收治的105例老年冠心病患者(> 80岁),随机分为三组,分别在PCI术前给予阿托伐他汀20mg /d、40mg /d、60mg /d。比较各组术后(术后1个月)主要不良心血管事件(mace)、心脏标志物、血管素和脂联素水平的变化。结果:各研究组中MACE发生率及pci相关心肌梗死发生率均以60 mg组最低(2.9%),差异有统计学意义(P < 0.05)。虽然术后心脏标志物水平显著升高(P < 0.05),但与他汀类药物剂量呈负相关(P < 0.05)。60 mg组术后血管素、脂联素、丙氨酸转氨酶水平显著升高(P < 0.05)。各组术前、术后血清肌酐、尿素氮水平比较差异无统计学意义(P > 0.05)。没有研究对象显示他汀类药物相关肌病。结论:短期内应用60mg /d他汀类药物强化治疗可改善老年冠心病患者PCI预后,维持心脏指标、Vaspin、脂联素水平稳定,疗效确切,安全性好。
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引用次数: 0
Minimally invasive treatment of pilonidal sinus disease using platelet-rich plasma 富血小板血浆微创治疗毛毛窦疾病
Pub Date : 2016-01-01 DOI: 10.4103/2468-5585.179563
Ö. Karahan, B. Sevinç, G. Şimşek, Recep Demirgül
Aim: Pilonidal disease is an inflammatory disorder, mainly affecting young adults. Platelet-rich plasma (PRP) is shown to have a positive impact on the wound healing process. Herein, the study aims to define the application of PRP and report early results. Methods: The study data were collected prospectively. PRP was prepared from the patients' own blood samples, transformed into gel form, and applied to the sinus tract under local anesthesia. Furthermore, the healing rate and recurrence rate of the disease were evaluated. Results: There were 50 cases included in the study, with 48 cases were cured at the end of the 1st month. At this stage, with a median follow-up of 15 months, there have been no documented recurrences. Conclusion: Minimally invasive treatment of pilonidal disease with PRP application has promising results. Treatment of pilonidal disease by PRP can be applied in outpatient clinic and provides total cure in a short time. The method is simple, painless, with no hospital stay required, less wound care, shorter time to return daily activity, and the cost is effective. However, long-term outcomes are unknown, and additional follow-up is required.
目的:毛线虫病是一种炎症性疾病,主要影响年轻人。富血小板血浆(PRP)被证明对伤口愈合过程有积极的影响。在此,本研究旨在明确PRP的应用并报告早期结果。方法:前瞻性收集研究资料。从患者自身的血液样本中制备PRP,转化为凝胶形式,在局部麻醉下应用于窦道。观察两组患者的治愈率和复发率。结果:本组共纳入50例,其中48例于治疗1月末治愈。在这一阶段,中位随访时间为15个月,无复发记录。结论:应用PRP微创治疗毛鞘疾病具有良好的效果。PRP治疗毛毛膜疾病可应用于门诊,可在短时间内完全治愈。该方法简单,无痛,无需住院,伤口护理少,恢复日常活动时间短,成本低。然而,长期结果尚不清楚,需要进一步随访。
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引用次数: 15
Laparoscopic cholecystostomy in treatment of obstructive jaundice 腹腔镜胆囊造瘘术治疗梗阻性黄疸
Pub Date : 2016-01-01 DOI: 10.4103/2468-5585.179561
Z. Rifatbegović, A. Mestric, Z. Mehmedović
Cholecystostomy is considered to be a treatment option when conservative treatment of acute cholecystitis failed in elderly and critically ill patients. The aim of this paper is to present a cholecystostomy in the treatment of obstructive jaundice before the definitive operation for the underlying cause of jaundice. The patient in poor general condition with the obstructive jaundice was diagnosed to have a pancreatic head tumor. He had undergone the laparoscopic cholecystostomy. After improvement of the general condition and lower total bilirubin level, the patient had undergone to definitive procedure. It is shown that laparoscopic cholecystostomy can be a successful way for adequate bile drainage in a patient with poor general condition before the definitive treatment of obstructive jaundice.
在老年和危重患者急性胆囊炎保守治疗失败时,胆囊造瘘被认为是一种治疗选择。本文的目的是提出胆囊造口术治疗梗阻性黄疸的最终手术前的根本原因黄疸。患者一般情况不佳,伴梗阻性黄疸,诊断为胰头肿瘤。他做了腹腔镜胆囊造口术。在一般情况改善和总胆红素水平降低后,患者接受了最终手术。结果表明,在梗阻性黄疸的最终治疗前,腹腔镜胆囊造口术可以成功地为一般情况较差的患者提供充分的胆汁引流。
{"title":"Laparoscopic cholecystostomy in treatment of obstructive jaundice","authors":"Z. Rifatbegović, A. Mestric, Z. Mehmedović","doi":"10.4103/2468-5585.179561","DOIUrl":"https://doi.org/10.4103/2468-5585.179561","url":null,"abstract":"Cholecystostomy is considered to be a treatment option when conservative treatment of acute cholecystitis failed in elderly and critically ill patients. The aim of this paper is to present a cholecystostomy in the treatment of obstructive jaundice before the definitive operation for the underlying cause of jaundice. The patient in poor general condition with the obstructive jaundice was diagnosed to have a pancreatic head tumor. He had undergone the laparoscopic cholecystostomy. After improvement of the general condition and lower total bilirubin level, the patient had undergone to definitive procedure. It is shown that laparoscopic cholecystostomy can be a successful way for adequate bile drainage in a patient with poor general condition before the definitive treatment of obstructive jaundice.","PeriodicalId":102077,"journal":{"name":"Translational Surgery","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122982290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Translational Surgery
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