Shun Zhang, T. Du, Dongyi Yan, Xiao-hua Jiang, C. Song
Aim: The aim of the study was to evaluate the cost of minimally invasive surgery using a modified uncut Roux-en-Y anastomosis technique in laparoscopic distal radical gastrectomy patients with gastric cancer. Methods: Clinical and cost data were reviewed on the perioperative outcomes of 15 gastric cancer patients who received laparoscopic distal radical gastrectomy using uncut Roux-en-Y anastomosis from January 2016 to December 2016 in the Department of Gastrointestinal Surgery, Shanghai East Hospital. Results: The mean operation time was 175 ± 30 min. Mean hospitalization expense was 9829 USD and mean linear stapler expense was 2940 USD. Laparoscopic distal radical gastrectomy with uncut Roux-en-Y anastomosis was successfully carried out in all the patients. There were no serious complications and no death in this series. Conclusion: Modified uncut Roux-en-Y anastomosis in laparoscopic distal radical gastrectomy may be a good way to balance the cost and minimally invasive surgery.
{"title":"A modified uncut roux-en-y anastomosis in laparoscopic-assisted distal gastrectomy: Balance of the cost and minimally invasion","authors":"Shun Zhang, T. Du, Dongyi Yan, Xiao-hua Jiang, C. Song","doi":"10.4103/TS.TS_20_17","DOIUrl":"https://doi.org/10.4103/TS.TS_20_17","url":null,"abstract":"Aim: The aim of the study was to evaluate the cost of minimally invasive surgery using a modified uncut Roux-en-Y anastomosis technique in laparoscopic distal radical gastrectomy patients with gastric cancer. Methods: Clinical and cost data were reviewed on the perioperative outcomes of 15 gastric cancer patients who received laparoscopic distal radical gastrectomy using uncut Roux-en-Y anastomosis from January 2016 to December 2016 in the Department of Gastrointestinal Surgery, Shanghai East Hospital. Results: The mean operation time was 175 ± 30 min. Mean hospitalization expense was 9829 USD and mean linear stapler expense was 2940 USD. Laparoscopic distal radical gastrectomy with uncut Roux-en-Y anastomosis was successfully carried out in all the patients. There were no serious complications and no death in this series. Conclusion: Modified uncut Roux-en-Y anastomosis in laparoscopic distal radical gastrectomy may be a good way to balance the cost and minimally invasive surgery.","PeriodicalId":102077,"journal":{"name":"Translational Surgery","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121449266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Polyether ether ketone (PEEK) has been widely used during the past decades in the medical field. Its versatile nature makes PEEK very popular in a variety of medical devices. The purpose of this article is to summarize the medical applications of PEEK in following fields: cranioplasty, dental implants, interbody fusion, joint replacements, soft-tissue repairs, and cardiac surgery. PEEK, as a biocompatible polymer, has been used in fields related to tissue fixation and reconstruction. This is largely due to its superior mechanical characteristics and biocompatibility. The author believes that as collaboration between medical professionals and engineers becomes more standard, PEEK and its composites will become more available and versatile.
{"title":"Medical applications of polyether ether ketone","authors":"Yitong Guo, Shenggui Chen, Jing Wang, B. Lu","doi":"10.4103/TS.TS_3_18","DOIUrl":"https://doi.org/10.4103/TS.TS_3_18","url":null,"abstract":"Polyether ether ketone (PEEK) has been widely used during the past decades in the medical field. Its versatile nature makes PEEK very popular in a variety of medical devices. The purpose of this article is to summarize the medical applications of PEEK in following fields: cranioplasty, dental implants, interbody fusion, joint replacements, soft-tissue repairs, and cardiac surgery. PEEK, as a biocompatible polymer, has been used in fields related to tissue fixation and reconstruction. This is largely due to its superior mechanical characteristics and biocompatibility. The author believes that as collaboration between medical professionals and engineers becomes more standard, PEEK and its composites will become more available and versatile.","PeriodicalId":102077,"journal":{"name":"Translational Surgery","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127534902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 62-year-old Vietnamese male presented for an elective video-assisted thoracoscopic surgery lobectomy for treatment of a suspicious lung mass. Postoperatively, he developed a hemorrhagic duodenal ulcer requiring endoscopic hemostasis. Interestingly, he subsequently became septic secondary to perforated acute appendicitis necessitating laparoscopic appendectomy. Surgery can evoke a physiological stress response and may be a causative factor in the pathogenesis of stress ulcers in surgical patients. A recent article has found an association between the development of acute appendicitis in patients with a history of peptic ulcer disease. The pathological mechanism responsible for this association may be the result of an imbalance of the autonomic nervous system and neuromusculature spasms at the ceco-appendiceal junction.
{"title":"Hemorrhagic duodenal ulcer and subsequent acute appendicitis following lobectomy for lung cancer","authors":"T. A. Moore, Steven T F Chan","doi":"10.4103/TS.TS_15_17","DOIUrl":"https://doi.org/10.4103/TS.TS_15_17","url":null,"abstract":"A 62-year-old Vietnamese male presented for an elective video-assisted thoracoscopic surgery lobectomy for treatment of a suspicious lung mass. Postoperatively, he developed a hemorrhagic duodenal ulcer requiring endoscopic hemostasis. Interestingly, he subsequently became septic secondary to perforated acute appendicitis necessitating laparoscopic appendectomy. Surgery can evoke a physiological stress response and may be a causative factor in the pathogenesis of stress ulcers in surgical patients. A recent article has found an association between the development of acute appendicitis in patients with a history of peptic ulcer disease. The pathological mechanism responsible for this association may be the result of an imbalance of the autonomic nervous system and neuromusculature spasms at the ceco-appendiceal junction.","PeriodicalId":102077,"journal":{"name":"Translational Surgery","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131537979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Verónica de los Santos, F. Salle, R. Lima, E. Spagnuolo
This study presents a very infrequent case of a young man with two different brain tumors. The peculiarity of this case is that both tumors appeared at the same time. The patient was admitted with headaches and confusion. Computed tomography scan and magnetic resonance imaging confirmed two tumors, one in the posterior fossa and another in the intraventricular supratentorial space. These findings were initially interpreted as the same tumor with two different localizations, a very infrequent situation. A first surgery was performed to remove the posterior fossa tumor. The pathology confirmed an hemangioblastoma. Six months later, a second surgery was performed for the supratentorial tumor. The surgical aspect was totally different compared to the tumor of the posterior fossa, and the pathology confirmed a central neurocytoma. The authors made a bibliographic review and did not find references of this association.
{"title":"Case of hemangioblastoma and central neurocytoma presenting as synchronous primary brain tumors in a young man","authors":"Verónica de los Santos, F. Salle, R. Lima, E. Spagnuolo","doi":"10.4103/TS.TS_11_17","DOIUrl":"https://doi.org/10.4103/TS.TS_11_17","url":null,"abstract":"This study presents a very infrequent case of a young man with two different brain tumors. The peculiarity of this case is that both tumors appeared at the same time. The patient was admitted with headaches and confusion. Computed tomography scan and magnetic resonance imaging confirmed two tumors, one in the posterior fossa and another in the intraventricular supratentorial space. These findings were initially interpreted as the same tumor with two different localizations, a very infrequent situation. A first surgery was performed to remove the posterior fossa tumor. The pathology confirmed an hemangioblastoma. Six months later, a second surgery was performed for the supratentorial tumor. The surgical aspect was totally different compared to the tumor of the posterior fossa, and the pathology confirmed a central neurocytoma. The authors made a bibliographic review and did not find references of this association.","PeriodicalId":102077,"journal":{"name":"Translational Surgery","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129377656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Vega-Ruiz, R. Ramos-Zúñiga, Ivan Segura Duran, Yara Ursiel-Ortega
Basic research provides the results necessary to pursue translational work, where basic and translational approaches used in conjunction can allow for an increased impact in solving public health problems. Biomaterials draws from both approaches and are used today in many surgical specialty areas, such as tissue regeneration and regenerative medicine. These materials can be used as replacements for tissue, as scaffolds for regeneration, as substrates for cell growth, as drug-releasing or bioactive molecule-releasing vehicles, and as several other medical devices. Biopolymers used in regenerative medicine provide a good example of such materials and demonstrate the methodology of a translational approach, where the product begins at the laboratory bench, is applied in preclinical stages, and is finally delivered as a new medical solution back to the patient. The biocompatible, biodegradable, and bioactive properties of some of these polymers have opened different possibilities for their use in the repair and/or regeneration of different tissues, including skin, bone, cartilage, nerves, liver, and muscle. This article serves as a review of the properties of these biopolymers, their use in tissue engineering, and promising alternatives in regenerative medicine.
{"title":"Biomaterials and surgical applications: The translational perspective","authors":"B. Vega-Ruiz, R. Ramos-Zúñiga, Ivan Segura Duran, Yara Ursiel-Ortega","doi":"10.4103/TS.TS_17_17","DOIUrl":"https://doi.org/10.4103/TS.TS_17_17","url":null,"abstract":"Basic research provides the results necessary to pursue translational work, where basic and translational approaches used in conjunction can allow for an increased impact in solving public health problems. Biomaterials draws from both approaches and are used today in many surgical specialty areas, such as tissue regeneration and regenerative medicine. These materials can be used as replacements for tissue, as scaffolds for regeneration, as substrates for cell growth, as drug-releasing or bioactive molecule-releasing vehicles, and as several other medical devices. Biopolymers used in regenerative medicine provide a good example of such materials and demonstrate the methodology of a translational approach, where the product begins at the laboratory bench, is applied in preclinical stages, and is finally delivered as a new medical solution back to the patient. The biocompatible, biodegradable, and bioactive properties of some of these polymers have opened different possibilities for their use in the repair and/or regeneration of different tissues, including skin, bone, cartilage, nerves, liver, and muscle. This article serves as a review of the properties of these biopolymers, their use in tissue engineering, and promising alternatives in regenerative medicine.","PeriodicalId":102077,"journal":{"name":"Translational Surgery","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127150949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Valentino's syndrome occurs when digestive fluids tend to settle in the right iliac fossa through a perforated gastric or duodenal ulcer, causing peritonitis and clinically mimicking acute appendicitis. Herein, we present the case of a 32-year-old male who was admitted to the emergency department with signs and symptoms suggestive of acute appendicitis. During laparoscopic appendectomy, inspection of the peritoneal cavity revealed an anterior, perforated duodenal ulcer, which was treated with a patch repair. The patient's recovery was uneventful, and a gastrointestinal endoscopy at his 6-week follow-up showed complete healing of the ulcer. This case highlights that Valentino's syndrome should be considered in the differential diagnosis of any patient who has an abdominal examination consistent with acute appendicitis.
{"title":"Valentino's syndrome: An unusual presentation of a perforated peptic ulcer","authors":"A. Sgró, M. Petkar, A. Benevento, F. Pata","doi":"10.4103/TS.TS_16_17","DOIUrl":"https://doi.org/10.4103/TS.TS_16_17","url":null,"abstract":"Valentino's syndrome occurs when digestive fluids tend to settle in the right iliac fossa through a perforated gastric or duodenal ulcer, causing peritonitis and clinically mimicking acute appendicitis. Herein, we present the case of a 32-year-old male who was admitted to the emergency department with signs and symptoms suggestive of acute appendicitis. During laparoscopic appendectomy, inspection of the peritoneal cavity revealed an anterior, perforated duodenal ulcer, which was treated with a patch repair. The patient's recovery was uneventful, and a gastrointestinal endoscopy at his 6-week follow-up showed complete healing of the ulcer. This case highlights that Valentino's syndrome should be considered in the differential diagnosis of any patient who has an abdominal examination consistent with acute appendicitis.","PeriodicalId":102077,"journal":{"name":"Translational Surgery","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133786997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-10-01DOI: 10.4103/2468-5585.221877
Xipeng Wang, Feng Ruan, Ping Liu
Aim: This study aims to compare the effect of large decompressive craniectomy combined with vascular reconstruction and traditional decompressive craniectomy in the treatment of severe craniocerebral injury. Methods: Forty-eight cases of severe craniocerebral injury were collected from March 2012 to March 2015 in Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology. Patients undergoing large decompressive craniectomy combined with vascular reconstruction or traditional decompressive craniectomy were randomly divided into two groups: the experimental group and the control group. The hemodynamic changes were observed by computed tomography perfusion, and the postoperative Glasgow Outcome Score (GOS) was analyzed. Results: The cerebral blood flow (CBF) and cerebral blood volume (CBV) scores in experimental group were higher than that in the control group at 1 week and 1 month after the operation (P < 0.05). The mean transit time (MTT) and time to peak (TTP) scores in experimental group were lower than that in the control group at 1 week and 1 month after the operation (P < 0.05). The relative CBF and relative CBV values of the control group in 1 week were higher than that in 1 month, while the relative MTT and relative TTP values in 1 week were lower than that in 1 month. The rate of good recovery (including good and residual cases) in experimental group was higher than that in the control group whereas the rate of poor recovery (including severe disability, vegetative state, and death) in experimental group was lower than that in the control group (P < 0.05). Conclusion: The large decompressive craniectomy combined with vascular reconstruction can not only decrease intracranial pressure but also recover the blood supply of the brain. It deserves the clinical promotion.
{"title":"Large decompressive craniectomy combined with vascular reconstruction in patients with severe craniocerebral injury","authors":"Xipeng Wang, Feng Ruan, Ping Liu","doi":"10.4103/2468-5585.221877","DOIUrl":"https://doi.org/10.4103/2468-5585.221877","url":null,"abstract":"Aim: This study aims to compare the effect of large decompressive craniectomy combined with vascular reconstruction and traditional decompressive craniectomy in the treatment of severe craniocerebral injury. Methods: Forty-eight cases of severe craniocerebral injury were collected from March 2012 to March 2015 in Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology. Patients undergoing large decompressive craniectomy combined with vascular reconstruction or traditional decompressive craniectomy were randomly divided into two groups: the experimental group and the control group. The hemodynamic changes were observed by computed tomography perfusion, and the postoperative Glasgow Outcome Score (GOS) was analyzed. Results: The cerebral blood flow (CBF) and cerebral blood volume (CBV) scores in experimental group were higher than that in the control group at 1 week and 1 month after the operation (P < 0.05). The mean transit time (MTT) and time to peak (TTP) scores in experimental group were lower than that in the control group at 1 week and 1 month after the operation (P < 0.05). The relative CBF and relative CBV values of the control group in 1 week were higher than that in 1 month, while the relative MTT and relative TTP values in 1 week were lower than that in 1 month. The rate of good recovery (including good and residual cases) in experimental group was higher than that in the control group whereas the rate of poor recovery (including severe disability, vegetative state, and death) in experimental group was lower than that in the control group (P < 0.05). Conclusion: The large decompressive craniectomy combined with vascular reconstruction can not only decrease intracranial pressure but also recover the blood supply of the brain. It deserves the clinical promotion.","PeriodicalId":102077,"journal":{"name":"Translational Surgery","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126573794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The purpose of the study is to verify if there is statistic difference of lung function before surgery based on differences in clinical characteristics (sex, age, degree of differentiation, size of tumor, tumor node metastasis (TNM), methods of surgeries, pleural metastasis, and lymph gland metastasis). Another purpose is to test if forced expiratory volume in 1 s/forced vital capacity obstruction (FEV1/FVC) is a risk factor of the prognosis of lung cancer. Methods: This retrospective study used t-test or analysis of variance to explore whether dramatic difference of lung function (FVC, FEV1, maximal voluntary ventilation [MVV], and FEV1/FVC) existed based on differences in clinical characteristics. The study used the Kaplan–Meier method to verify if FEV1/FVC could be a risk factor to predict the prognosis of lung cancer patients after surgeries. Results: The statistical results indicated that statistical difference of FVC existed between different age groups. In patients of different ages and sexes, there was statistically different MVV. Results of FEV1/FVC showed that FEV1/FVC varied dramatically in patients of different pleural metastasis conditions or TNM. Analysis of prognosis proved that in patients with a different differentiation degree, size of tumor, metastasis conditions of lymph gland, and TNM stage, a statistically different prognosis was found. As for groups of normal and abnormal FEV1/FVC, no apparently different prognosis was observed. Analysis of lung cancer patients of stage I indicated that the 5-year survival was dramatically different between patients of normal and abnormal FEV1/FVC. Conclusion: In lung cancer patients of stage I, FEV1/FVC was one of the risk factors of prognosis.
{"title":"A preliminary study on forced expiratory volume in 1 s/forced vital capacity to predict prognosis of patients with lung cancer","authors":"Yechi Li, Ji-Yuan Tian","doi":"10.4103/TS.TS_37_16","DOIUrl":"https://doi.org/10.4103/TS.TS_37_16","url":null,"abstract":"Aim: The purpose of the study is to verify if there is statistic difference of lung function before surgery based on differences in clinical characteristics (sex, age, degree of differentiation, size of tumor, tumor node metastasis (TNM), methods of surgeries, pleural metastasis, and lymph gland metastasis). Another purpose is to test if forced expiratory volume in 1 s/forced vital capacity obstruction (FEV1/FVC) is a risk factor of the prognosis of lung cancer. Methods: This retrospective study used t-test or analysis of variance to explore whether dramatic difference of lung function (FVC, FEV1, maximal voluntary ventilation [MVV], and FEV1/FVC) existed based on differences in clinical characteristics. The study used the Kaplan–Meier method to verify if FEV1/FVC could be a risk factor to predict the prognosis of lung cancer patients after surgeries. Results: The statistical results indicated that statistical difference of FVC existed between different age groups. In patients of different ages and sexes, there was statistically different MVV. Results of FEV1/FVC showed that FEV1/FVC varied dramatically in patients of different pleural metastasis conditions or TNM. Analysis of prognosis proved that in patients with a different differentiation degree, size of tumor, metastasis conditions of lymph gland, and TNM stage, a statistically different prognosis was found. As for groups of normal and abnormal FEV1/FVC, no apparently different prognosis was observed. Analysis of lung cancer patients of stage I indicated that the 5-year survival was dramatically different between patients of normal and abnormal FEV1/FVC. Conclusion: In lung cancer patients of stage I, FEV1/FVC was one of the risk factors of prognosis.","PeriodicalId":102077,"journal":{"name":"Translational Surgery","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124567993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarcomatoid renal cell carcinoma (SRCC), an advanced and uncommon form of renal cell carcinoma (RCC), is more likely to manifest as a unilateral condition, especially in the right kidney, in older people. Here, we report a rare case of bilateral SRCC in a young female, aged 30 years - the youngest reported case of SRCC to the best of our knowledge. The patient complained of osphyalgia and intermittent fever which recurred after symptomatic treatment. Detailed examination, including histopathological analysis of biopsies, confirmed bilateral SRCC (RCC IV) with distant metastases. The patient denied receiving any form of the treatment, including surgery, radiotherapy, and chemotherapy and died approximately 6 months after the initial symptoms.
{"title":"Bilateral sarcomatoid renal cell carcinoma: An uncommon case in young female patient","authors":"Yuan Gao, Weibing Shuang, Xu-nan Tong, Yuhang Zhang","doi":"10.4103/TS.TS_6_17","DOIUrl":"https://doi.org/10.4103/TS.TS_6_17","url":null,"abstract":"Sarcomatoid renal cell carcinoma (SRCC), an advanced and uncommon form of renal cell carcinoma (RCC), is more likely to manifest as a unilateral condition, especially in the right kidney, in older people. Here, we report a rare case of bilateral SRCC in a young female, aged 30 years - the youngest reported case of SRCC to the best of our knowledge. The patient complained of osphyalgia and intermittent fever which recurred after symptomatic treatment. Detailed examination, including histopathological analysis of biopsies, confirmed bilateral SRCC (RCC IV) with distant metastases. The patient denied receiving any form of the treatment, including surgery, radiotherapy, and chemotherapy and died approximately 6 months after the initial symptoms.","PeriodicalId":102077,"journal":{"name":"Translational Surgery","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129968798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pengliang Chen, W. Lai, Zerong Chen, Shao-bin Zheng
While angiomyolipoma (AML) is a fairly common urological tumor, malignant AMLs rarely appear in clinical practice. As such, currently there exists little knowledge of malignant AMLs. This article discusses the differences between benign and malignant AMLs. Besides, we report two cases of AML with opposite nature in Nan Fang Hospital from 2010 to 2016 and discuss the key features based on clinical manifestation, pathogenesis, radiology, and pathology. Case 1 was a 44-year-old, asymptomatic female presenting with a mass measuring 4 cm in diameter in the inferior pole of the left kidney. Case 2 was a 23-year-old female presenting with abdominal pain for 1 month, a mass measuring 5.5 cm in diameter in the superior pole of the right kidney, regional infiltration, and enlarged retroperitoneal lymph nodes. Based on Folpe's grading scheme, the Case 1 tumor was benign due to the absence of criteria mentioned in the grade and the Case 2 tumor was malignant due to a tumor size >5 cm, infiltrative growth pattern, necrosis, high nuclear grade, and subsequent aggressive clinical behavior. Each patient underwent surgical resection: Case 1 demonstrated no evidence of recurrence at the 9-month follow-up; however, Case 2 died 3 years postoperation due to tumor recurrence. These results demonstrate that malignant AML has aggressive biological activities and almost always associates with unfavorable prognoses. Therefore, a strict follow-up should be given to “uncertain malignant potential” patients, and surgical resection should be performed.
{"title":"Malignant and benign renal perivascular epithelioid cell tumors: A comparison and review of the literature","authors":"Pengliang Chen, W. Lai, Zerong Chen, Shao-bin Zheng","doi":"10.4103/TS.TS_14_17","DOIUrl":"https://doi.org/10.4103/TS.TS_14_17","url":null,"abstract":"While angiomyolipoma (AML) is a fairly common urological tumor, malignant AMLs rarely appear in clinical practice. As such, currently there exists little knowledge of malignant AMLs. This article discusses the differences between benign and malignant AMLs. Besides, we report two cases of AML with opposite nature in Nan Fang Hospital from 2010 to 2016 and discuss the key features based on clinical manifestation, pathogenesis, radiology, and pathology. Case 1 was a 44-year-old, asymptomatic female presenting with a mass measuring 4 cm in diameter in the inferior pole of the left kidney. Case 2 was a 23-year-old female presenting with abdominal pain for 1 month, a mass measuring 5.5 cm in diameter in the superior pole of the right kidney, regional infiltration, and enlarged retroperitoneal lymph nodes. Based on Folpe's grading scheme, the Case 1 tumor was benign due to the absence of criteria mentioned in the grade and the Case 2 tumor was malignant due to a tumor size >5 cm, infiltrative growth pattern, necrosis, high nuclear grade, and subsequent aggressive clinical behavior. Each patient underwent surgical resection: Case 1 demonstrated no evidence of recurrence at the 9-month follow-up; however, Case 2 died 3 years postoperation due to tumor recurrence. These results demonstrate that malignant AML has aggressive biological activities and almost always associates with unfavorable prognoses. Therefore, a strict follow-up should be given to “uncertain malignant potential” patients, and surgical resection should be performed.","PeriodicalId":102077,"journal":{"name":"Translational Surgery","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122439569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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