Pub Date : 2020-03-15DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.06.005
Zhiying Ma, Zhi-Zhen Qin, Lifang Zhao, Q. Ren
Objective To observe the efficacy of tedrogesterone tablets combined with clomiphene on polycystic ovary syndrome(PCOS) with infertility, and investigate its influence on serum levels of apolipoprotein B/apolipoprotein A1 ratio(ApoB/ApoA1), anti-mullerian hormone(AMH), advanced glycation end products(AGEs). Methods From January 2017 to December 2018, 80 PCOS patients with infertility who met the criteria were screened and randomly divided into control group and observation group according to the digital table, with 40 cases in each group.The control group received clomiphene 50 mg/d, qd, and for 5 consecutive days.In the observation group, on the basis of the control group, tedrosterone tablet was added, 10 mg/time and qd, and continuously administered for 21 days.The two groups were treated for 4 menstrual cycles.The ovarian volume, follicular development, pregnancy rate, hormone levels, the endometrial receptivity, and serum ApoB/ApoA1, AMH, AGEs levels were compared between the two groups. Results After treatment, the ovarian volume[(5.62±0.87)cm3]of the observation group was significantly smaller than that of the control group[(7.94±1.03)cm3](t=7.722, P=0.000), and the maximum diameter of follicles in the observation group[(13.30±2.04)mm] was significantly larger than that in the control group[(11.12±1.83)mm](t=5.530, P=0.0001). The pregnancy rate in the observation group was significantly higher than that in the control group(χ2=4.990, P=0.025). The serum levels of follicle stimulating hormone(FSH)[(4.80±0.56)IU/L], luteinizing hormone(LH)[(7.35±0.11)IU/L], uterine pulse index(PI)(2.77±0.41), and uterine artery resistance index(RI)(0.61±0.09) in the observation group were significantly lower than those in the control group(t=5.003, P=0.000; t=6.449, P=0.000; t=5.304, P=0.000; t=5.008, P=0.000), and the estradiol(E2)[(190.51±23.11)ng/L] and endometrial thickness[(10.11±1.57)mm] were significantly higher than those in the control group(t=38.521, P=0.000; t=6.001, P=0.000). The serum levels of ApoB/ApoA1(0.62±0.08), AMH[(4.13±0.61)μg/L], and AGEs[(118.04±13.35)ng/L] in the observation group were significantly lower than those in the control group(t=5.553, P=0.000; t=5.790, P=0.000; t=18.043, P=0.000). Conclusion The efficacy of tedrogesterone tablets combined with clomiphene on PCOS with infertility is significant, and can down-regulate serum levels of ApoB/ApoA1, AMH, and AGEs. Key words: Tedrogesterone; Polycystic ovary syndrome; Clomiphene; Infertility, female; Apolipoprotein B; Apolipoprotein A; Anti-mullerian hormone; Glycosylation end products, advanced; Hormone
目的观察氢孕酮片联合克罗米芬治疗多囊卵巢综合征(PCOS)合并不孕症的疗效，并探讨其对血清载脂蛋白B/载脂蛋白A1比值(ApoB/ApoA1)、抗苗勒管激素(AMH)、晚期糖基化终产物(AGEs)水平的影响。方法筛选2017年1月~ 2018年12月符合标准的PCOS不孕患者80例，按数字表随机分为对照组和观察组，每组40例。对照组患者给予克罗米芬50 mg/d, qd，连续5 d。观察组在对照组的基础上加用睾酮片，10 mg/次，qd，连续给药21 d。两组均治疗4个月经周期。比较两组患者卵巢体积、卵泡发育、妊娠率、激素水平、子宫内膜容受性及血清ApoB/ApoA1、AMH、AGEs水平。结果治疗后，观察组卵巢体积[(5.62±0.87)cm3]显著小于对照组[(7.94±1.03)cm3](t=7.722, P=0.000)，卵泡最大直径[(13.30±2.04)mm]显著大于对照组[(11.12±1.83)mm](t=5.530, P=0.0001)。观察组妊娠率显著高于对照组(χ2=4.990, P=0.025)。观察组患者血清促卵泡激素(FSH)[(4.80±0.56)IU/L]、促黄体生成素(LH)[(7.35±0.11)IU/L]、子宫脉搏指数(PI)(2.77±0.41)、子宫动脉阻力指数(RI)(0.61±0.09)水平均显著低于对照组(t=5.003, P=0.000;t = 6.449, P = 0.000;t = 5.304, P = 0.000;t=5.008, P=0.000)，雌二醇(E2)[(190.51±23.11)ng/L]和子宫内膜厚度[(10.11±1.57)mm]均显著高于对照组(t=38.521, P=0.000;t = 6.001, P = 0.000)。观察组患者血清ApoB/ApoA1(0.62±0.08)、AMH[(4.13±0.61)μg/L]、AGEs[(118.04±13.35)ng/L]水平均显著低于对照组(t=5.553, P=0.000;t = 5.790, P = 0.000;t = 18.043, P = 0.000)。结论氢孕酮片联合克罗米芬治疗PCOS合并不孕症疗效显著，可下调血清ApoB/ApoA1、AMH、AGEs水平。关键词:黄体酮;多囊卵巢综合征;克罗米酚;女性不孕;载脂蛋白B;载脂蛋白A;她们血液中的抗苗勒氏管激素;糖基化终产物，先进;激素
{"title":"Effects of tedrogesterone tablets combined with clomiphene on polycystic ovary syndrome with infertility and its influence on serum levels of apolipoprotein B/apolipoprotein A1 ratio, anti-mullerian hormone, advanced glycation end products","authors":"Zhiying Ma, Zhi-Zhen Qin, Lifang Zhao, Q. Ren","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.005","url":null,"abstract":"Objective \u0000To observe the efficacy of tedrogesterone tablets combined with clomiphene on polycystic ovary syndrome(PCOS) with infertility, and investigate its influence on serum levels of apolipoprotein B/apolipoprotein A1 ratio(ApoB/ApoA1), anti-mullerian hormone(AMH), advanced glycation end products(AGEs). \u0000 \u0000 \u0000Methods \u0000From January 2017 to December 2018, 80 PCOS patients with infertility who met the criteria were screened and randomly divided into control group and observation group according to the digital table, with 40 cases in each group.The control group received clomiphene 50 mg/d, qd, and for 5 consecutive days.In the observation group, on the basis of the control group, tedrosterone tablet was added, 10 mg/time and qd, and continuously administered for 21 days.The two groups were treated for 4 menstrual cycles.The ovarian volume, follicular development, pregnancy rate, hormone levels, the endometrial receptivity, and serum ApoB/ApoA1, AMH, AGEs levels were compared between the two groups. \u0000 \u0000 \u0000Results \u0000After treatment, the ovarian volume[(5.62±0.87)cm3]of the observation group was significantly smaller than that of the control group[(7.94±1.03)cm3](t=7.722, P=0.000), and the maximum diameter of follicles in the observation group[(13.30±2.04)mm] was significantly larger than that in the control group[(11.12±1.83)mm](t=5.530, P=0.0001). The pregnancy rate in the observation group was significantly higher than that in the control group(χ2=4.990, P=0.025). The serum levels of follicle stimulating hormone(FSH)[(4.80±0.56)IU/L], luteinizing hormone(LH)[(7.35±0.11)IU/L], uterine pulse index(PI)(2.77±0.41), and uterine artery resistance index(RI)(0.61±0.09) in the observation group were significantly lower than those in the control group(t=5.003, P=0.000; t=6.449, P=0.000; t=5.304, P=0.000; t=5.008, P=0.000), and the estradiol(E2)[(190.51±23.11)ng/L] and endometrial thickness[(10.11±1.57)mm] were significantly higher than those in the control group(t=38.521, P=0.000; t=6.001, P=0.000). The serum levels of ApoB/ApoA1(0.62±0.08), AMH[(4.13±0.61)μg/L], and AGEs[(118.04±13.35)ng/L] in the observation group were significantly lower than those in the control group(t=5.553, P=0.000; t=5.790, P=0.000; t=18.043, P=0.000). \u0000 \u0000 \u0000Conclusion \u0000The efficacy of tedrogesterone tablets combined with clomiphene on PCOS with infertility is significant, and can down-regulate serum levels of ApoB/ApoA1, AMH, and AGEs. \u0000 \u0000 \u0000Key words: \u0000Tedrogesterone; Polycystic ovary syndrome; Clomiphene; Infertility, female; Apolipoprotein B; Apolipoprotein A; Anti-mullerian hormone; Glycosylation end products, advanced; Hormone","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47100484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-15DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.06.007
Jie Liu, Jin Zhao, Yanfei Fang, Zhenyu Wang, M. Zhai, Xiaoe Wang, Xin Zhao
Objective To analyze the effect and safety of levonorgestrel-releasing intrauterine system(LNG-IUS) for the premenopausal patients with breast cancer who took tamoxifen as adjuvant therapy. Methods From June 2014 to June 2016, 84 patients with breast cancer who met the inclusion criteria in the First People′s Hospital of Xiaoshan District were randomly divided into two groups according to the digital table.The treatment group (39 cases) underwent LNG-IUS insertion, while the control group (45 cases) received no LNG-IUS insertion.The general condition of patients before the use of tamoxifen and LNG-IUS was evaluated.Transvaginal ultrasound was used to measure the thickness of endometrium, hysteroscope was used for pathological examination of endometrium and the measurement of ER/PR expression, and blood lipid level was also detected.All above was done before the treatment of tamoxifen and LNG-IUS, 1 year after treatment and 2 years after treatment. Results Before the therapy, there were no statistically significant differences between the two groups in general condition and uterine cavity condition(all P>0.05). After 1 year, the incidences of endometrial polyp, endometrial hyperplasia/secretion, benign lesion and endometrial atrophy in the treatment group were 2.6%, 5.1%, 15.4%, 76.9%, respectively, which in the control group were 6.7%, 20.0%, 17.8%, 55.6%, respectively.the differences between the two groups were statistically significant(χ2=4.06, 4.22, all P<0.05). After 2 years, the incidences of endometrial polyp, endometrial hyperplasia/secretion, benign lesion and endometrial atrophy in the treatment group were 0.0%, 2.6%, 84.6%, respectively, which in the control group were 11.1%, 15.6%, 60.0%, respectively, the differences between the two groups were statistically significant(χ2=4.608, 4.092, 6.203, all P<0.05). Conclusion LNG-IUS can prevent the benign endometrial lesions of breast cancer patients caused by tamoxifen therapy after surgery, and can decrease the incidence of endometrial polyp and endometrial hyperplasia/secretion, while increase the incidence of endometrial atrophy, without increasing the recurrence risk of breast cancer. Key words: Intrauterine devices, Medicated; Levonorgestrel; Tamoxifen; Breast neoplasms; Premenopause; Endometrium
{"title":"Analysis of the effect and safety of levonorgestrel-releasing intrauterine system on patients with breast cancer who take tamoxifen","authors":"Jie Liu, Jin Zhao, Yanfei Fang, Zhenyu Wang, M. Zhai, Xiaoe Wang, Xin Zhao","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.007","url":null,"abstract":"Objective \u0000To analyze the effect and safety of levonorgestrel-releasing intrauterine system(LNG-IUS) for the premenopausal patients with breast cancer who took tamoxifen as adjuvant therapy. \u0000 \u0000 \u0000Methods \u0000From June 2014 to June 2016, 84 patients with breast cancer who met the inclusion criteria in the First People′s Hospital of Xiaoshan District were randomly divided into two groups according to the digital table.The treatment group (39 cases) underwent LNG-IUS insertion, while the control group (45 cases) received no LNG-IUS insertion.The general condition of patients before the use of tamoxifen and LNG-IUS was evaluated.Transvaginal ultrasound was used to measure the thickness of endometrium, hysteroscope was used for pathological examination of endometrium and the measurement of ER/PR expression, and blood lipid level was also detected.All above was done before the treatment of tamoxifen and LNG-IUS, 1 year after treatment and 2 years after treatment. \u0000 \u0000 \u0000Results \u0000Before the therapy, there were no statistically significant differences between the two groups in general condition and uterine cavity condition(all P>0.05). After 1 year, the incidences of endometrial polyp, endometrial hyperplasia/secretion, benign lesion and endometrial atrophy in the treatment group were 2.6%, 5.1%, 15.4%, 76.9%, respectively, which in the control group were 6.7%, 20.0%, 17.8%, 55.6%, respectively.the differences between the two groups were statistically significant(χ2=4.06, 4.22, all P<0.05). After 2 years, the incidences of endometrial polyp, endometrial hyperplasia/secretion, benign lesion and endometrial atrophy in the treatment group were 0.0%, 2.6%, 84.6%, respectively, which in the control group were 11.1%, 15.6%, 60.0%, respectively, the differences between the two groups were statistically significant(χ2=4.608, 4.092, 6.203, all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000LNG-IUS can prevent the benign endometrial lesions of breast cancer patients caused by tamoxifen therapy after surgery, and can decrease the incidence of endometrial polyp and endometrial hyperplasia/secretion, while increase the incidence of endometrial atrophy, without increasing the recurrence risk of breast cancer. \u0000 \u0000 \u0000Key words: \u0000Intrauterine devices, Medicated; Levonorgestrel; Tamoxifen; Breast neoplasms; Premenopause; Endometrium","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44554423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-15DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.06.001
R. Dong, Yanan Ji
Objective To analyze the risk factors of positive surgical margin and residual lesions after cone resection of high-grade intraepithelial neoplasia, and to guide clinical work and follow-up. Methods The clinical data of 180 patients with cervical epithelial neoplasia of grade Ⅱ and Ⅲ who underwent cervical conization in the People's Hospital of Inner Mongolia Autonomous Region from November 2013 to November 2018 were retrospectively analyzed.The risk factors associated with residual margin and reoperation (including re-cone and hysterectomy) after conization were performed by single factor and multivariate regression analysis. Results The incidence of positive resection margins after conization was 31.67%(57/180), which of the residual margin of re-surgery was 36.84%(21/57). Menopause, contact bleeding, cervical cancer(in situ carcinoma, microinvasive carcinoma) were positive risk factors for conical cutting margin (OR=2.342, 2.428, 8.949). Contact bleeding, cervical cancer(in situ carcinoma, microinvasive carcinoma) were risk factors for residual resection of the surgical margin after conization (OR=5.370, 10.992). Conclusion Contact bleeding, cervical carcinoma in situ, microinvasive carcinoma are closely related to cervical margin and lesion residual.Among them, menopause is also positively related to margin, which is a risk factor affecting cervical cone cutting margin and residual reoperation.It should be highly valued in clinical. Key words: Cervical intraepithelial neoplasia; Conization; Reoperation; Regression analysis; Risk factors
{"title":"Analysis of risk factors of positive surgical margin and residual lesions after cone resection of high-grade intraepithelial neoplasia","authors":"R. Dong, Yanan Ji","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.001","url":null,"abstract":"Objective \u0000To analyze the risk factors of positive surgical margin and residual lesions after cone resection of high-grade intraepithelial neoplasia, and to guide clinical work and follow-up. \u0000 \u0000 \u0000Methods \u0000The clinical data of 180 patients with cervical epithelial neoplasia of grade Ⅱ and Ⅲ who underwent cervical conization in the People's Hospital of Inner Mongolia Autonomous Region from November 2013 to November 2018 were retrospectively analyzed.The risk factors associated with residual margin and reoperation (including re-cone and hysterectomy) after conization were performed by single factor and multivariate regression analysis. \u0000 \u0000 \u0000Results \u0000The incidence of positive resection margins after conization was 31.67%(57/180), which of the residual margin of re-surgery was 36.84%(21/57). Menopause, contact bleeding, cervical cancer(in situ carcinoma, microinvasive carcinoma) were positive risk factors for conical cutting margin (OR=2.342, 2.428, 8.949). Contact bleeding, cervical cancer(in situ carcinoma, microinvasive carcinoma) were risk factors for residual resection of the surgical margin after conization (OR=5.370, 10.992). \u0000 \u0000 \u0000Conclusion \u0000Contact bleeding, cervical carcinoma in situ, microinvasive carcinoma are closely related to cervical margin and lesion residual.Among them, menopause is also positively related to margin, which is a risk factor affecting cervical cone cutting margin and residual reoperation.It should be highly valued in clinical. \u0000 \u0000 \u0000Key words: \u0000Cervical intraepithelial neoplasia; Conization; Reoperation; Regression analysis; Risk factors","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42167379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-15DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.06.020
Yuanyuan Chen, Qin Liu, Qilan Chen, Jia Zhou
Objective To investigate the clinical efficacy and safety of Zhibitai capsule in the treatment of senile hyperlipidemia patients with phlegm and blood stasis syndrome. Methods From June 2014 to June 2015, 126 elderly patients with primary hyperlipidemia of phlegm and blood stasis syndrome admitted to Hangzhou Hospital of Traditional Chinese Medicine were randomly divided into control group and observation group, with 63 cases in each group.The patients in the control group were given basic treatment plus atorvastatin calcium tablets, and the patients in the observation group were treated with Zhibitai capsule on the basis of the control study.Both two groups received continuous treatment for 12 weeks.The clinical efficacy, TCM syndrome integral, blood lipid, hemorheology and adverse reactions of the two groups were observed. Results The total effective rate in the observation group was 92.1%(58/63), which was higher than 81.0%(51/63) in the control group, and the difference was statistically significant(χ2=8.199, P 0.05). Conclusion Zhibitai capsule can effectively improve the clinical efficacy, improve TCM syndromes, reduce blood lipids and improve hemorheology parameters in elderly patients with hyperlipidemia syndrome of phlegm and blood stasis syndrome, with no obvious adverse reactions, which is worthy of clinical promotion. Key words: Hyperlipidemia; Senile; Phlegm and blood stasis syndrome; Zhibitai capsule; Chinese patent medicine; Hemorheology; Clinical efficacy; Blood lipid
{"title":"Clinical effect of Zhibitai capsule in the treatment of senile hyperlipidemia patients with phlegm and blood stasis syndrome","authors":"Yuanyuan Chen, Qin Liu, Qilan Chen, Jia Zhou","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.020","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.020","url":null,"abstract":"Objective \u0000To investigate the clinical efficacy and safety of Zhibitai capsule in the treatment of senile hyperlipidemia patients with phlegm and blood stasis syndrome. \u0000 \u0000 \u0000Methods \u0000From June 2014 to June 2015, 126 elderly patients with primary hyperlipidemia of phlegm and blood stasis syndrome admitted to Hangzhou Hospital of Traditional Chinese Medicine were randomly divided into control group and observation group, with 63 cases in each group.The patients in the control group were given basic treatment plus atorvastatin calcium tablets, and the patients in the observation group were treated with Zhibitai capsule on the basis of the control study.Both two groups received continuous treatment for 12 weeks.The clinical efficacy, TCM syndrome integral, blood lipid, hemorheology and adverse reactions of the two groups were observed. \u0000 \u0000 \u0000Results \u0000The total effective rate in the observation group was 92.1%(58/63), which was higher than 81.0%(51/63) in the control group, and the difference was statistically significant(χ2=8.199, P 0.05). \u0000 \u0000 \u0000Conclusion \u0000Zhibitai capsule can effectively improve the clinical efficacy, improve TCM syndromes, reduce blood lipids and improve hemorheology parameters in elderly patients with hyperlipidemia syndrome of phlegm and blood stasis syndrome, with no obvious adverse reactions, which is worthy of clinical promotion. \u0000 \u0000 \u0000Key words: \u0000Hyperlipidemia; Senile; Phlegm and blood stasis syndrome; Zhibitai capsule; Chinese patent medicine; Hemorheology; Clinical efficacy; Blood lipid","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46986420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-15DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.06.010
Hongren Wang, J. Peng, Zi-Gang Yuan
Objective To investigate the imaging characteristics of pregnant women complicated with posterior reversible encephalopathy syndrome(PRES), in order to improve the understanding of the disease. Methods The clinical and imaging data of 17 pregnant patients complicated with PRES from July 2011 to July 2017 of the People′s Hospital of Huadu District in Guangzhou were analyzed retrospectively. Results All patients were preeclampsia or eclampsia in pregnancy (5 cases with eclampsia, 12 cases with eclampsia). Among them, 8 cases underwent CT examination, 9 cases underwent MRI examination Typical imaging findings were symmetrical subcortical white matter and subcortical cerebral edema presented as irregular low density area on CT images and symmetric subcortical white matter and abnormal cortical signal on MRI fluid-attenuated inversion recovery (FLAIR)images.Diffuse-limited signals were not observed in both DWI and ADC.The location of lesions were parieto-occipital lobes[100.0%(17/17)], followed by frontallobe[88.9%(15/17)], temporal lobe[29.4%(5/17)], basal ganglia[41.2%(7/17)], corpus callosum[17.6%(3/17)], radiant crown[11.8%(2/17)]and cerebellum[11.8%(2/17)]. After symptomatic treatment, the clinical symptoms of all patients were significantly improved after 1-2 weeks, and no clinical symptoms were observed after 1-3 months of follow-up. Conclusion The characteristic imaging features can be assessed in pregnant patients complicated with PRES, which presented as symmetrical subcortical white matter and subcortical cerebral edema, mainly involved the region supplied by posterior circulation, got good results after treatment timely. Key words: Brain disease; Posterior reversible encephalopathy syndrome; Pregnancy; Cerebral edema vasongenic; Magnetic resonance imaging; Tomography; X-Ray computed; Differential diagnosis
{"title":"Analysis of clinical and imaging features of 17 pregnant patients complicated with PRES","authors":"Hongren Wang, J. Peng, Zi-Gang Yuan","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.010","url":null,"abstract":"Objective \u0000To investigate the imaging characteristics of pregnant women complicated with posterior reversible encephalopathy syndrome(PRES), in order to improve the understanding of the disease. \u0000 \u0000 \u0000Methods \u0000The clinical and imaging data of 17 pregnant patients complicated with PRES from July 2011 to July 2017 of the People′s Hospital of Huadu District in Guangzhou were analyzed retrospectively. \u0000 \u0000 \u0000Results \u0000All patients were preeclampsia or eclampsia in pregnancy (5 cases with eclampsia, 12 cases with eclampsia). Among them, 8 cases underwent CT examination, 9 cases underwent MRI examination Typical imaging findings were symmetrical subcortical white matter and subcortical cerebral edema presented as irregular low density area on CT images and symmetric subcortical white matter and abnormal cortical signal on MRI fluid-attenuated inversion recovery (FLAIR)images.Diffuse-limited signals were not observed in both DWI and ADC.The location of lesions were parieto-occipital lobes[100.0%(17/17)], followed by frontallobe[88.9%(15/17)], temporal lobe[29.4%(5/17)], basal ganglia[41.2%(7/17)], corpus callosum[17.6%(3/17)], radiant crown[11.8%(2/17)]and cerebellum[11.8%(2/17)]. After symptomatic treatment, the clinical symptoms of all patients were significantly improved after 1-2 weeks, and no clinical symptoms were observed after 1-3 months of follow-up. \u0000 \u0000 \u0000Conclusion \u0000The characteristic imaging features can be assessed in pregnant patients complicated with PRES, which presented as symmetrical subcortical white matter and subcortical cerebral edema, mainly involved the region supplied by posterior circulation, got good results after treatment timely. \u0000 \u0000 \u0000Key words: \u0000Brain disease; Posterior reversible encephalopathy syndrome; Pregnancy; Cerebral edema vasongenic; Magnetic resonance imaging; Tomography; X-Ray computed; Differential diagnosis","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42272708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-15DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.06.015
Yan Qin, Li-xing Xu, Dong Peng, Yi Wang, Chunfen Li, Yan-Li Zhou, Tian Chen, Peng Zhang, Chengjing Tang, J. Xia, Yan Li
Objective To explore the association of peripheral blood neutrophil lymphocyte ratio(NLR) with primary osteoporosis (POP) in Chinese elderly women. Methods From December 2015 to April 2019, a total of 788 elderly women in Chongqing Three Gorges Central Hospital were included in this study.They were divided into three groups according to bone mineral density: 242 cases of osteopenia, 206 cases of normal bone mineral density and 340 cases of osteoporosis.Their height, weight, statuses of bone of left femoral neck and results of blood tests were recorded, and the values of BMI, NLR and OSTA were calculated.The SPSS statistics software was used to analyze the differences of parameters among the three groups.Logistic regression analysis was used to get significant independent related factors for osteoporosis.The relationship of NLR and OSTA with T-score of left femoral neck was confirmed by Pearson correlation test.ROC curves were used to define the values of NLR and OSTA in diagnosis of osteoporosis. Results There were statistically significant differences in age(median values: 66, 68 and 70, χ2=71.596, P<0.001), BMI(median values: 23.46, 24.04 and 25.415, χ2=64.936, P<0.001) and NLR(median values: 1.97, 2.435 and 2.84, χ2=106.218, P<0.001) among the three groups(all P<0.01). Logistic regression analysis demonstrated that age, BMI and NLR were all independent significant related factors.There was correlation of NLR, OSTA with T-score of left femoral neck.In diagnosis of osteoporosis, the cut-off value, maximum Youden index, sensitivity and specificity were 2.395, 0.299, 70.3%, 59.6% for NLR, and -1.315, 0.174, 73.6%, 43.5% for OSTA. Conclusion NLR has intermediate sensitivity and specificity in screening POP in Chinese elderly women, and deserves future researches. Key words: Osteoporosis; Granulocytes; Lymphocytes; OSTA; Bone mineral density; Sensitivity; Specificity; ROC curve; Aged
{"title":"Relationship between peripheral blood neutrophil lymphocyte ratio and osteoporosis in Chinese elderly women","authors":"Yan Qin, Li-xing Xu, Dong Peng, Yi Wang, Chunfen Li, Yan-Li Zhou, Tian Chen, Peng Zhang, Chengjing Tang, J. Xia, Yan Li","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.015","url":null,"abstract":"Objective \u0000To explore the association of peripheral blood neutrophil lymphocyte ratio(NLR) with primary osteoporosis (POP) in Chinese elderly women. \u0000 \u0000 \u0000Methods \u0000From December 2015 to April 2019, a total of 788 elderly women in Chongqing Three Gorges Central Hospital were included in this study.They were divided into three groups according to bone mineral density: 242 cases of osteopenia, 206 cases of normal bone mineral density and 340 cases of osteoporosis.Their height, weight, statuses of bone of left femoral neck and results of blood tests were recorded, and the values of BMI, NLR and OSTA were calculated.The SPSS statistics software was used to analyze the differences of parameters among the three groups.Logistic regression analysis was used to get significant independent related factors for osteoporosis.The relationship of NLR and OSTA with T-score of left femoral neck was confirmed by Pearson correlation test.ROC curves were used to define the values of NLR and OSTA in diagnosis of osteoporosis. \u0000 \u0000 \u0000Results \u0000There were statistically significant differences in age(median values: 66, 68 and 70, χ2=71.596, P<0.001), BMI(median values: 23.46, 24.04 and 25.415, χ2=64.936, P<0.001) and NLR(median values: 1.97, 2.435 and 2.84, χ2=106.218, P<0.001) among the three groups(all P<0.01). Logistic regression analysis demonstrated that age, BMI and NLR were all independent significant related factors.There was correlation of NLR, OSTA with T-score of left femoral neck.In diagnosis of osteoporosis, the cut-off value, maximum Youden index, sensitivity and specificity were 2.395, 0.299, 70.3%, 59.6% for NLR, and -1.315, 0.174, 73.6%, 43.5% for OSTA. \u0000 \u0000 \u0000Conclusion \u0000NLR has intermediate sensitivity and specificity in screening POP in Chinese elderly women, and deserves future researches. \u0000 \u0000 \u0000Key words: \u0000Osteoporosis; Granulocytes; Lymphocytes; OSTA; Bone mineral density; Sensitivity; Specificity; ROC curve; Aged","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41381150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-15DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.06.006
Xiaohe Wang, Qi Ma, Zhengyue Qian, Xiaoyan Pan
Objective To study the effect of low-dose aspirin combined with letrozole on serum visfatin, monocyte chemoattractant protein-1(MCP-1) and pregnancy rate in patients with polycystic ovary syndrome(PCOS). Methods From November 2016 to November 2018, 110 patients with PCOS in the Third People's Hospital of Datong were selected.According to the random number table, they were divided into the observation group(60 cases) and the control group(50 cases). The control group was treated with letrozole, while the observation group was given letrozole combined with low-dose aspirin.The patients were continuously treated for 3 menstrual cycles.The changes of the serum visfatin, MCP-1, sex hormones, uterine artery blood flow before and after treatment, pregnancy and adverse reactions were compared between the two groups. Results After treatment, the serum visfatin, MCP-1, testosterone (T), luteinizing hormone (LH), LH/follicular estrogen (FSH), uterine arterial pulsation index (PI) and resistance index (RI) in the observation group were (11.03±2.17)ng/mL, (99.31±14.50)ng/L, (1.57±0.29)mmol/L, (6.57±1.30)U/L, (1.16±0.22), (1.07±0.24), (0.41±0.08), respectively, which were significantly lower than those in the control group[(15.57±2.56)ng/mL, (121.29±20.37)ng/L, (1.78±0.32)mmol/L, (8.40±1.88)U/L, (1.50±0.27), (1.45±0.29), (0.57±0.11)], the differences were statistically significant(t=10.068, 6.593, 3.608, 6.012, 7.278, 7.521, 8.815, all P 0.05). Conclusion Low-dose aspirin combined with letrozole in the treatment of PCOS can effectively reduce the serum visfatin and MCP-1, regulate the sex hormones levels, improve uterine artery blood flow, improve pregnancy rate, and without increasing adverse drug reactions, so it's worthy of popularizing. Key words: Polycystic ovary syndrome; Aspirin; Letrozole; Drug therapy, combination; Visfatin; Monocyte chemoattractant proteins; Gonadal hormones; Uterine artery; Pregnancy
{"title":"Effects of low-dose aspirin combined with letrozole on serum visfatin, monocyte chemoattractant protein-1 and pregnancy rate in patients with polycystic ovary syndrome","authors":"Xiaohe Wang, Qi Ma, Zhengyue Qian, Xiaoyan Pan","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.006","url":null,"abstract":"Objective \u0000To study the effect of low-dose aspirin combined with letrozole on serum visfatin, monocyte chemoattractant protein-1(MCP-1) and pregnancy rate in patients with polycystic ovary syndrome(PCOS). \u0000 \u0000 \u0000Methods \u0000From November 2016 to November 2018, 110 patients with PCOS in the Third People's Hospital of Datong were selected.According to the random number table, they were divided into the observation group(60 cases) and the control group(50 cases). The control group was treated with letrozole, while the observation group was given letrozole combined with low-dose aspirin.The patients were continuously treated for 3 menstrual cycles.The changes of the serum visfatin, MCP-1, sex hormones, uterine artery blood flow before and after treatment, pregnancy and adverse reactions were compared between the two groups. \u0000 \u0000 \u0000Results \u0000After treatment, the serum visfatin, MCP-1, testosterone (T), luteinizing hormone (LH), LH/follicular estrogen (FSH), uterine arterial pulsation index (PI) and resistance index (RI) in the observation group were (11.03±2.17)ng/mL, (99.31±14.50)ng/L, (1.57±0.29)mmol/L, (6.57±1.30)U/L, (1.16±0.22), (1.07±0.24), (0.41±0.08), respectively, which were significantly lower than those in the control group[(15.57±2.56)ng/mL, (121.29±20.37)ng/L, (1.78±0.32)mmol/L, (8.40±1.88)U/L, (1.50±0.27), (1.45±0.29), (0.57±0.11)], the differences were statistically significant(t=10.068, 6.593, 3.608, 6.012, 7.278, 7.521, 8.815, all P 0.05). \u0000 \u0000 \u0000Conclusion \u0000Low-dose aspirin combined with letrozole in the treatment of PCOS can effectively reduce the serum visfatin and MCP-1, regulate the sex hormones levels, improve uterine artery blood flow, improve pregnancy rate, and without increasing adverse drug reactions, so it's worthy of popularizing. \u0000 \u0000 \u0000Key words: \u0000Polycystic ovary syndrome; Aspirin; Letrozole; Drug therapy, combination; Visfatin; Monocyte chemoattractant proteins; Gonadal hormones; Uterine artery; Pregnancy","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41620540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-15DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.06.003
Xiaoxiao Huang, Xiaolu Chen, Xiaoyan Wang
Objective To investigate the clinical effect of ethinylestradiol cycloproterone combined with metformin in the treatment of polycystic ovary syndrome (PCOS) with insulin resistance. Methods Ninety PCOS patients with insulin resistance admitted to the First People's Hospital of Taizhou from May 2017 to May 2019 were selected in the study.According to the random number table method, the patients were divided into control group and treatment group, with 45 cases in each group.The control group was treated with ethinylestradiol and cycloprogesterone, while the observation group was treated with ethinylestradiol and cycloprogesterone combined with metformin.The clinical effects of two groups were compared, including estradiol (E2), testosterone (T), luteinizing hormone (LH), follicle stimulating estrogen (FSH), insulin resistance index (HOMA-IR), fasting plasma glucose (FPG) before and after treatment.Body mass index (BMI) and fasting insulin (FINS) levels were measured.The ovulation, pregnancy, menstrual recovery and adverse reactions of the two groups were analyzed. Results The total effective rate of the treatment group (97.77%) was significantly higher than that of the control group (77.77%), the difference was statistically significant (χ2=8.389, P=0.003). Before treatment, there were no statistically significant differences in E2, T, LH, FSH between the treatment group and the control group (all P>0.05). After treatment, the levels of E2[(112.90±18.90)pmol/L], T[(1.30±0.78)nmol/L], LH[(8.00±1.50)U/L]and FSH[(1.20±0.39)U/L] in the treatment group were significantly lower than those in the control group[E2(128.90±19.95) pmol/L, T(2.19±1.00) nmol/L, LH(11.65±1.60)U/L and FSH(1.89±0.50)U/L], the differences were statistically significant(t=3.905, 4.707, 10.871, 7.299, all P 0.05). After treatment, the levels of HOMA-IR (2.19±0.50), FPG[(4.30±1.19)mmol/L], BMI[(22.40±1.89)kg/m2], FINS[(15.98±5.00)mU/L] in the treatment group were significantly lower than those in the control group[HOMA-IR(3.90±0.58), FPG (6.09±1.20) mmol/L, BMI (24.69±4.60)kg/m2, FINS (19.00±6.89)mU/L], the differences were statistically significant(t=14.979, 7.105, 3.089, 2.379, all P<0.05). The ovulation, pregnancy and menstrual recovery in the treatment group were significantly higher than those in the control group (χ2=4.121, 4.285, 10.000, all P<0.05). The incidence of adverse reactions in the treatment group (13.33%) was significantly lower than that in the control group (37.77%), the difference was statistically significant between the two groups (χ2=7.066, P=0.007). Conclusion Ethinylestradiol cycloproterone combined with metformin in the treatment of PCOS with insulin resistance has significant clinical efficacy, can alleviate the endocrine metabolic disorders and insulin resistance, it is worthy of clinical application and promotion. Key words: Polycystic ovary syndrome; Insulin resistance; Ethinyl estradiol; Gyproterone; Metformin; Sex hormones; Li
{"title":"Clinical effect of ethinylestradiol cycloproterone combined with metformin in the treatment of PCOS patients with insulin resistance","authors":"Xiaoxiao Huang, Xiaolu Chen, Xiaoyan Wang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.003","url":null,"abstract":"Objective \u0000To investigate the clinical effect of ethinylestradiol cycloproterone combined with metformin in the treatment of polycystic ovary syndrome (PCOS) with insulin resistance. \u0000 \u0000 \u0000Methods \u0000Ninety PCOS patients with insulin resistance admitted to the First People's Hospital of Taizhou from May 2017 to May 2019 were selected in the study.According to the random number table method, the patients were divided into control group and treatment group, with 45 cases in each group.The control group was treated with ethinylestradiol and cycloprogesterone, while the observation group was treated with ethinylestradiol and cycloprogesterone combined with metformin.The clinical effects of two groups were compared, including estradiol (E2), testosterone (T), luteinizing hormone (LH), follicle stimulating estrogen (FSH), insulin resistance index (HOMA-IR), fasting plasma glucose (FPG) before and after treatment.Body mass index (BMI) and fasting insulin (FINS) levels were measured.The ovulation, pregnancy, menstrual recovery and adverse reactions of the two groups were analyzed. \u0000 \u0000 \u0000Results \u0000The total effective rate of the treatment group (97.77%) was significantly higher than that of the control group (77.77%), the difference was statistically significant (χ2=8.389, P=0.003). Before treatment, there were no statistically significant differences in E2, T, LH, FSH between the treatment group and the control group (all P>0.05). After treatment, the levels of E2[(112.90±18.90)pmol/L], T[(1.30±0.78)nmol/L], LH[(8.00±1.50)U/L]and FSH[(1.20±0.39)U/L] in the treatment group were significantly lower than those in the control group[E2(128.90±19.95) pmol/L, T(2.19±1.00) nmol/L, LH(11.65±1.60)U/L and FSH(1.89±0.50)U/L], the differences were statistically significant(t=3.905, 4.707, 10.871, 7.299, all P 0.05). After treatment, the levels of HOMA-IR (2.19±0.50), FPG[(4.30±1.19)mmol/L], BMI[(22.40±1.89)kg/m2], FINS[(15.98±5.00)mU/L] in the treatment group were significantly lower than those in the control group[HOMA-IR(3.90±0.58), FPG (6.09±1.20) mmol/L, BMI (24.69±4.60)kg/m2, FINS (19.00±6.89)mU/L], the differences were statistically significant(t=14.979, 7.105, 3.089, 2.379, all P<0.05). The ovulation, pregnancy and menstrual recovery in the treatment group were significantly higher than those in the control group (χ2=4.121, 4.285, 10.000, all P<0.05). The incidence of adverse reactions in the treatment group (13.33%) was significantly lower than that in the control group (37.77%), the difference was statistically significant between the two groups (χ2=7.066, P=0.007). \u0000 \u0000 \u0000Conclusion \u0000Ethinylestradiol cycloproterone combined with metformin in the treatment of PCOS with insulin resistance has significant clinical efficacy, can alleviate the endocrine metabolic disorders and insulin resistance, it is worthy of clinical application and promotion. \u0000 \u0000 \u0000Key words: \u0000Polycystic ovary syndrome; Insulin resistance; Ethinyl estradiol; Gyproterone; Metformin; Sex hormones; Li","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49310790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-15DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.06.016
Qi Sun, Haijun Yang
Objective To investigate the effect of montelukast sodium tablets combined with pulmicort aerosol in the treatment of children with asthma, and its influence on eosinophil (EOS), interleukin-4 (IL-4), immunoglobulin E (IgE), tumor necrosis factor-α (TNF-α). Methods From March 2018 to March 2019, 142 children with asthma admitted to Hangzhou Dajiangdong Hospita were randomly divided into observation group (71 cases) and control group (71 cases) according to the digital table.The patients in the observation group were treated with montelukast sodium tablets combined with pulmicort aerosol, while patients in the control group were treated with pulmicort aerosol.Both two groups were treated for 2 weeks.The levels of EOS, IL-4, IgE and TNF-α, day and night asthma symptom scores and blood gas analysis indicators before and after treatment were compared between the two groups. Results The total effective rate of the observation group (91.55%) was higher than that of the control group (74.65%) (χ2=7.220, P<0.05). After treatment, the scores of asthma symptoms in day[(0.38±0.12)points] and night[(0.42±0.14)points] in the observation group were lower than those in the control group[(0.87±0.19)points and (0.93±0.25)ponts](t=18.373, 14.998, all P<0.05). After treatment, the levels of EOS[(0.38±0.09)×109/L], IL-4[(13.89±3.25)ng/L], IgE[(109.35±16.57)kU/L] and TNF-α[(1.25±0.12)ng/L] in the observation group were lower than those in the control group[(0.73±0.13)×109/L, (18.36±2.70)ng/L, (164.53±23.51)kU/L and (1.49±0.15)ng/L](t=18.652, 8.914, 16.165, 10.528, all P<0.05). Conclusion Montelukast sodium tablets combined with pulmicort aerosol is effective in the treatment of children with asthma.It can reduce the levels of EOS, IL-4, IgE and TNF-α, alleviate the symptoms of daytime and night asthma. Key words: Asthma; Eosinophils; Interleukin-4; Immunoglobulin E; Tumor necrosis factor-a; Montelukast sodium; Pulmicort aerosol; child
{"title":"Effects of montelukast sodium tablets combined with pulmicort aerosol in the treatment of children with asthma and its influence on EOS, IL-4, IgE, TNF-α","authors":"Qi Sun, Haijun Yang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.016","url":null,"abstract":"Objective \u0000To investigate the effect of montelukast sodium tablets combined with pulmicort aerosol in the treatment of children with asthma, and its influence on eosinophil (EOS), interleukin-4 (IL-4), immunoglobulin E (IgE), tumor necrosis factor-α (TNF-α). \u0000 \u0000 \u0000Methods \u0000From March 2018 to March 2019, 142 children with asthma admitted to Hangzhou Dajiangdong Hospita were randomly divided into observation group (71 cases) and control group (71 cases) according to the digital table.The patients in the observation group were treated with montelukast sodium tablets combined with pulmicort aerosol, while patients in the control group were treated with pulmicort aerosol.Both two groups were treated for 2 weeks.The levels of EOS, IL-4, IgE and TNF-α, day and night asthma symptom scores and blood gas analysis indicators before and after treatment were compared between the two groups. \u0000 \u0000 \u0000Results \u0000The total effective rate of the observation group (91.55%) was higher than that of the control group (74.65%) (χ2=7.220, P<0.05). After treatment, the scores of asthma symptoms in day[(0.38±0.12)points] and night[(0.42±0.14)points] in the observation group were lower than those in the control group[(0.87±0.19)points and (0.93±0.25)ponts](t=18.373, 14.998, all P<0.05). After treatment, the levels of EOS[(0.38±0.09)×109/L], IL-4[(13.89±3.25)ng/L], IgE[(109.35±16.57)kU/L] and TNF-α[(1.25±0.12)ng/L] in the observation group were lower than those in the control group[(0.73±0.13)×109/L, (18.36±2.70)ng/L, (164.53±23.51)kU/L and (1.49±0.15)ng/L](t=18.652, 8.914, 16.165, 10.528, all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Montelukast sodium tablets combined with pulmicort aerosol is effective in the treatment of children with asthma.It can reduce the levels of EOS, IL-4, IgE and TNF-α, alleviate the symptoms of daytime and night asthma. \u0000 \u0000 \u0000Key words: \u0000Asthma; Eosinophils; Interleukin-4; Immunoglobulin E; Tumor necrosis factor-a; Montelukast sodium; Pulmicort aerosol; child","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45593705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-15DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.06.014
Dian Li, L. Bai
Objective To explore the related factors of anterior cruciate ligament rupture with meniscus injury and the effect of arthroscopic surgery. Methods From July 2014 to May 2018, 98 patients with anterior cruciate ligament rupture admitted to Shengjing Hospital Affiliated to China Medical University were divided into meniscus injury group(67 cases) and without meniscus injury group(31 cases) according to whether they had meniscus injury.The patients with anterior cruciate ligament rupture and meniscal injury were divided into study group(37 cases underwent arthroscopic reconstruction of anterior cruciate ligament and meniscus injury), and 30 cases in control group(only meniscus was repaired under arthroscopy). The factors affecting the anterior cruciate ligament rupture associated with meniscus were analyzed, and the surgical outcomes of the study group and the control group(the cure rate of meniscus injury and the 1-year reoperation rate, IKDC and Lysholm knee function score) were compared. Results Multivariate logistic regression analysis showed that early course of disease[95%CI(1.444, 41.68), P<0.05], middle course of disease[95%CI(1.682, 52.147), P<0.05], chronic phase[95%CI(3.623, 180.32), P<0.05]), history of recurrent injury[95%CI(2.649, 27.222), P<0.05]) were risk factors of meniscus injury caused by rupture of anterior cruciate ligament.The treatment rate of meniscus injury in the study group[89.19%(33/37)]was higher than that in the control group[66.67%(20/30)], the reoperation rate in the study group[5.41%(2/37)]was lower than that in the control group[26.67%(8/30)], the differences were statistically significant (χ2=5.084, 5.898, all P<0.05). At 12 months after operation, the scores of IKDC and Lysholm in the study group were (90.25±14.67)points and (88.36±11.25)points, respectively, which were significantly higher than those in the control group[(73.52±10.12)points and (71.47±10.68)points](t=12.129, 19.309, all P<0.05). Conclusion The patients with anterior cruciate ligament rupture complicated with meniscus are associated with history and recurrent injury history.Arthroscopic surgery for simultaneous reconstruction of anterior cruciate ligament and meniscus injury can significantly improve knee joint function, improve the cure rate of meniscus injury in this type of patients, and reduce short-term reoperation rate. Key words: Anterior cruciate ligament; Menisci, tibial; Knee Joint; Wounds and injuries; Arthroscopy; Factor analysis, statistical
{"title":"Analysis of related factors of anterior cruciate ligament rupture with meniscus and the effect of arthroscopic surgery","authors":"Dian Li, L. Bai","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.014","url":null,"abstract":"Objective \u0000To explore the related factors of anterior cruciate ligament rupture with meniscus injury and the effect of arthroscopic surgery. \u0000 \u0000 \u0000Methods \u0000From July 2014 to May 2018, 98 patients with anterior cruciate ligament rupture admitted to Shengjing Hospital Affiliated to China Medical University were divided into meniscus injury group(67 cases) and without meniscus injury group(31 cases) according to whether they had meniscus injury.The patients with anterior cruciate ligament rupture and meniscal injury were divided into study group(37 cases underwent arthroscopic reconstruction of anterior cruciate ligament and meniscus injury), and 30 cases in control group(only meniscus was repaired under arthroscopy). The factors affecting the anterior cruciate ligament rupture associated with meniscus were analyzed, and the surgical outcomes of the study group and the control group(the cure rate of meniscus injury and the 1-year reoperation rate, IKDC and Lysholm knee function score) were compared. \u0000 \u0000 \u0000Results \u0000Multivariate logistic regression analysis showed that early course of disease[95%CI(1.444, 41.68), P<0.05], middle course of disease[95%CI(1.682, 52.147), P<0.05], chronic phase[95%CI(3.623, 180.32), P<0.05]), history of recurrent injury[95%CI(2.649, 27.222), P<0.05]) were risk factors of meniscus injury caused by rupture of anterior cruciate ligament.The treatment rate of meniscus injury in the study group[89.19%(33/37)]was higher than that in the control group[66.67%(20/30)], the reoperation rate in the study group[5.41%(2/37)]was lower than that in the control group[26.67%(8/30)], the differences were statistically significant (χ2=5.084, 5.898, all P<0.05). At 12 months after operation, the scores of IKDC and Lysholm in the study group were (90.25±14.67)points and (88.36±11.25)points, respectively, which were significantly higher than those in the control group[(73.52±10.12)points and (71.47±10.68)points](t=12.129, 19.309, all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The patients with anterior cruciate ligament rupture complicated with meniscus are associated with history and recurrent injury history.Arthroscopic surgery for simultaneous reconstruction of anterior cruciate ligament and meniscus injury can significantly improve knee joint function, improve the cure rate of meniscus injury in this type of patients, and reduce short-term reoperation rate. \u0000 \u0000 \u0000Key words: \u0000Anterior cruciate ligament; Menisci, tibial; Knee Joint; Wounds and injuries; Arthroscopy; Factor analysis, statistical","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43365229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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