Pub Date : 2020-04-01DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.07.009
S. Pan, Hui Wang, Yuanyuan Wang, Jia Wei, Na Liu
Objective To study the diagnostic value of serum microRNA21 and tumor markers CEA, CYFRA21-1 and NSE in early non-small cell lung cancer (NSCLC). Methods From January 2018 to March 2019, 22 patients with NSCLC in Daqing Longnan Hospital were selected as the study group, and 22 people who underwent health examination in our hospital during the same period were selected as the control group.The levels of serum microRNA21, major tumor markers and the relationship between pathological types and markers were observed and analyzed. Results The serum levels of miRNA-21 (2.15±0.9), CEA [(34.1±4.9)ng/mL], NSE [(27.1±2.2)ng/mL], and CYFRA21-1 [(12.1±1.2)ng/mL] in the study group were higher than those in the control group(t=6.524, 27.392, 23.339, 27.685, all P=0.000). The serum levels of miRNA-21 (1.88±1.14), CEA [(30.1±19.9)ng/mL], CYFRA21-1 [(12.8±5.2)ng/mL] in adenocarcinoma patients were lower than those in patients with squamous cell carcinoma, and the level of NSE [(26.1±3.2)ng/mL] was higher than that of patients with squamous cell carcinomas (t=1.158, 1.192, 0.423, 1.913, P=0.260, 0.247, 0.677, 0.070). The serum levels of miRNA-21 (2.58±0.96), CEA [(38.1±17.9)ng/mL], CYFRA21-1 [(16.8±6.2)ng/mL], NSE [(26.9±10.2)ng/mL] in NSCLC patients with Ⅲ~Ⅳ stage were higher than those in NSCLC patients with Ⅰ-Ⅱ stage, but only CYFRA21-1 had statistically significant difference(P<0.05), there were no statistically significant differences in the other three indicators (t=1.478, 0.574, 2.114, 1.015, P=0.155, 0.573, 0.047, 0.322). Conclusion The combined examination of serum microRNA-21 and tumor markers CEA, CYFRA21-1 and NSE in patients with NSCLC can effectively confirm the diagnosis, which is very important for the diagnosis, treatment and prognosis of patients.This diagnosis can be the first choice for patients with NSCLC. Key words: Carcinoma, non-small-cell lung; MicroRNA-21; Carcinoembryonic antigen; Cytokeratin 19-fragments; Neuron specific enolase; Early stage; Diagnostic value
{"title":"Diagnostic value of serum microRNA21 and tumor markers CEA, CYFRA21-1 and NSE in early non-small cell lung cancer","authors":"S. Pan, Hui Wang, Yuanyuan Wang, Jia Wei, Na Liu","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.07.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.07.009","url":null,"abstract":"Objective To study the diagnostic value of serum microRNA21 and tumor markers CEA, CYFRA21-1 and NSE in early non-small cell lung cancer (NSCLC). Methods From January 2018 to March 2019, 22 patients with NSCLC in Daqing Longnan Hospital were selected as the study group, and 22 people who underwent health examination in our hospital during the same period were selected as the control group.The levels of serum microRNA21, major tumor markers and the relationship between pathological types and markers were observed and analyzed. Results The serum levels of miRNA-21 (2.15±0.9), CEA [(34.1±4.9)ng/mL], NSE [(27.1±2.2)ng/mL], and CYFRA21-1 [(12.1±1.2)ng/mL] in the study group were higher than those in the control group(t=6.524, 27.392, 23.339, 27.685, all P=0.000). The serum levels of miRNA-21 (1.88±1.14), CEA [(30.1±19.9)ng/mL], CYFRA21-1 [(12.8±5.2)ng/mL] in adenocarcinoma patients were lower than those in patients with squamous cell carcinoma, and the level of NSE [(26.1±3.2)ng/mL] was higher than that of patients with squamous cell carcinomas (t=1.158, 1.192, 0.423, 1.913, P=0.260, 0.247, 0.677, 0.070). The serum levels of miRNA-21 (2.58±0.96), CEA [(38.1±17.9)ng/mL], CYFRA21-1 [(16.8±6.2)ng/mL], NSE [(26.9±10.2)ng/mL] in NSCLC patients with Ⅲ~Ⅳ stage were higher than those in NSCLC patients with Ⅰ-Ⅱ stage, but only CYFRA21-1 had statistically significant difference(P<0.05), there were no statistically significant differences in the other three indicators (t=1.478, 0.574, 2.114, 1.015, P=0.155, 0.573, 0.047, 0.322). Conclusion The combined examination of serum microRNA-21 and tumor markers CEA, CYFRA21-1 and NSE in patients with NSCLC can effectively confirm the diagnosis, which is very important for the diagnosis, treatment and prognosis of patients.This diagnosis can be the first choice for patients with NSCLC. Key words: Carcinoma, non-small-cell lung; MicroRNA-21; Carcinoembryonic antigen; Cytokeratin 19-fragments; Neuron specific enolase; Early stage; Diagnostic value","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41824088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-15DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.06.028
Weiren Liang
Elastography is a new technique for noninvasive evaluation of tissue resistance to external hardness and deformation, which plays an increasingly important role in the diagnosis and differential diagnosis of thyroid, breast, liver, prostate and other organs in recent years.This paper reviews the application progress of elastography in various organs. Key words: Ultrasonography; Elasticity Imaging techniques; Thyroid diseases; Breast diseases; Liver diseases; Prostatism; Genital diseases, female; Review
{"title":"Progress of application of real-time ultrasound elastography in clinical","authors":"Weiren Liang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.028","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.028","url":null,"abstract":"Elastography is a new technique for noninvasive evaluation of tissue resistance to external hardness and deformation, which plays an increasingly important role in the diagnosis and differential diagnosis of thyroid, breast, liver, prostate and other organs in recent years.This paper reviews the application progress of elastography in various organs. \u0000 \u0000Key words: \u0000Ultrasonography; Elasticity Imaging techniques; Thyroid diseases; Breast diseases; Liver diseases; Prostatism; Genital diseases, female; Review","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45827464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To explore the application effect of early rehabilitation nursing led by stroke specialist nurses in patients with ischemic stroke. Method: 120 patients with ischemic stroke admitted to the People's Hospital of Xinjiang Uygur Autonomous Region from January 2018 to January 2019 were selected as the study subjects. According to the random number table method, the patients were divided into a control group of 60 cases and an observation group of 60 cases. The control group received routine nursing care for ischemic stroke; The observation group implemented an early rehabilitation nursing model led by stroke specialist nurses. Compare the degree of neurological impairment, daily living activity, hemiplegic limb motor function, and satisfaction between two groups of patients. After the intervention, the observation group's National Institutes of Health Stroke Scale (NIHSS), Barthel Index Rating Scale (BI), and Simplified Fugl Meyer Motor Function (FMA) scores were (12.37 ± 2.65), (43.81 ± 5.63), and (52.36 ± 9.01), respectively, which were better than the control group's (14.21 ± 2.43), (40.28 ± 4.54), and (45.25 ± 8.03) scores (t=5.126, -0.239, -2.45, all P<0.05); The total satisfaction score of the observation group patients was (90.05 ± 1.61) points, which was higher than the control group's (80.19 ± 1.62) points (t=-5.267, P<0.05). Conclusion: The implementation of an early rehabilitation nursing model led by stroke specialist nurses can effectively improve patients' limb dysfunction, enhance their self-management ability, standardize the early rehabilitation nursing workflow, and improve work quality.
{"title":"Application of early rehabilitation nursing leaded by stroke specialist nurses in patients with ischemic stroke","authors":"Li Zhu, Xiaolin Cao, M. Hou, Ping Li","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.026","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.026","url":null,"abstract":"目的 \u0000探讨以卒中专科护士为主导的早期康复护理在缺血性脑卒中患者中的应用效果。 \u0000 \u0000 \u0000方法 \u0000选择新疆维吾尔自治区人民医院2018年1月至2019年1月住院治疗的缺血性脑卒中患者120例为研究对象，根据随机数字表法将患者分为对照组60例、观察组60例。对照组给予缺血性脑卒中常规护理模式；观察组实施以卒中专科护士为主导的早期康复护理模式。比较两组患者神经功能缺损程度、日常生活活动能力、偏瘫肢体运动功能及满意度。 \u0000 \u0000 \u0000结果 \u0000干预后，观察组美国国立卫生研究院卒中量表(NIHSS)、Barthel指数评定量表(BI)、简式Fugl-Meyer运动功能(FMA)评分分别为(12.37±2.65)分、(43.81±5.63)分、(52.36±9.01)分，均优于对照组的(14.21±2.43)分、(40.28±4.54)分、(45.25±8.03)分(t＝5.126、－0.239、－2.45，均P<0.05)；观察组患者满意度评分总分为(90.05±1.61)分，高于对照组的(80.19±1.62)分(t＝－5.267，P<0.05)。 \u0000 \u0000 \u0000结论 \u0000实施以卒中专科护士为主导的早期康复护理模式能有效改善患者肢体功能障碍，提高患者自我管理能力，有利于规范早期康复护理工作流程，提升工作质量。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45352043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of early warning score in the observation of children triage","authors":"Jijie Chen","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.027","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.027","url":null,"abstract":"目的 \u0000观察早期预警评分系统在留诊观察患儿护理中的应用价值。 \u0000 \u0000 \u0000方法 \u0000选取舟山市妇幼保健医院2018年1－12月收治的急诊留诊观察患儿680例，根据护理方法不同分为对照组和观察组。对照组患儿采取常规急诊护理，观察组采取儿童早期预警评分系统进行护理，比较两组临床护理效果。 \u0000 \u0000 \u0000结果 \u0000观察组患儿主要临床症状消退时间(1.09±0.72)d，留诊时间(3.21±1.16)d，留诊观察费用(3.09±1.28)千元，转入相关科室住院准确率96.76%(329/340)；对照组患儿主要临床症状消退时间(2.85±1.45)d，留诊时间(6.88±2.87)d，留诊观察费用(4.85±2.13)千元，转入相关科室住院准确率90.00%(316/340)，两组差异均有统计学意义(t＝11.534、9.102、10.328、12.545，均P<0.05)。观察组并发症发生率1.47%(5/340)，护理满意度评分(95.88±1.97)分；对照组并发症发生率5.59%(19/340)，护理满意度评分(89.31±4.23)分，组间差异均有统计学意义(t或χ2＝3.881、14.552，均P<0.05)。 \u0000 \u0000 \u0000结论 \u0000早期预警评分系统应用在留诊观察患儿护理中可以缩短留诊时间，提升转入科室准确率，提升护理满意度，值得在临床进一步推广。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43840971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To study the effect of sedative combined with cis-atracurium in rapid induction intubation in emergency department. Methods From October 15, 2017 to April 15, 2019, 52 critically ill patients who needed tracheal intubation in emergency department of the People's Hospital of Changzhi were selected.And the patients were numbered according to the time sequence of enrollment, and then randomly divided into group A and group B according to the random number table, with 26 cases in each group.Group A was given sedatives combined with cis-atracurium to induce rapid intubation.Group B only received sedatives to induce intubation.The success rate of intubation, successful intubation time were compared between the two groups.Before and after endotracheal intubation, the heart rate, mean arterial blood pressure, pulse oxygen concentration and the change of catecholamine concentration were compared. Results The success rate of intubation in group A was 100.0%, which in group B was 76.9%, the difference between the two groups was statistically significant (χ2=12.15, P 0.05). The serum adrenaline level was higher compared with before intubation, but there was no statistically significant difference (t=-1.03, P>0.05). In group B, the pulse oxygen concentration was significantly increased after intubation compared with before intubation (t=5.74, P 0.05). Conclusion In the airway management of critically ill patients in emergency department, the application of sedatives combined with cis-atracurium to rapidly induce intubation can improve the hypoxia symptoms of patients more rapidly and can keep patients' hemodynamics, catecholamine concentration is relatively stable, it has the characteristics of safety and efficiency. Key words: Emergency service, hospital; Emergencies; Critical illness; Airway management; Intubation, intratracheal; Atracurium; Hypnotics and sedatives; Hemodynamics
目的探讨镇静剂联合顺式阿曲库铵在急诊科快速诱导插管中的应用效果。方法选取2017年10月15日至2019年4月15日长治市人民医院急诊科需要气管插管的危重患者52例。并将患者按入组时间顺序编号，再按随机数字表随机分为A组和B组，每组26例。A组给予镇静剂联合顺式阿曲库铵诱导快速插管。B组仅给予镇静剂诱导插管。比较两组插管成功率、插管成功时间。比较气管插管前后心率、平均动脉压、脉氧浓度及儿茶酚胺浓度的变化。结果A组插管成功率为100.0%，B组为76.9%，两组比较差异有统计学意义(χ2=12.15, p0.05)。血清肾上腺素水平高于插管前，但差异无统计学意义(t=-1.03, P < 0.05)。B组插管后脉搏氧浓度较插管前显著升高(t=5.74, P < 0.05)。结论在急诊科危重患者气道管理中，应用镇静剂联合顺式阿曲库铵快速诱导插管能更迅速地改善患者缺氧症状，并能保持患者血流动力学，儿茶酚胺浓度相对稳定，具有安全、有效的特点。关键词:急救服务;医院;紧急情况;重要的疾病;气道管理;插管、气管内的;阿曲库;催眠药和镇静剂;血液动力学
{"title":"Application of rapid induction of intubation by sedatives combined with cis-atracurium in the emergency department","authors":"Qiang Yang, Chao Tian, Xurong Li, Liang Ma, Shuzhen Bi, Jinhua Chen","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.018","url":null,"abstract":"Objective \u0000To study the effect of sedative combined with cis-atracurium in rapid induction intubation in emergency department. \u0000 \u0000 \u0000Methods \u0000From October 15, 2017 to April 15, 2019, 52 critically ill patients who needed tracheal intubation in emergency department of the People's Hospital of Changzhi were selected.And the patients were numbered according to the time sequence of enrollment, and then randomly divided into group A and group B according to the random number table, with 26 cases in each group.Group A was given sedatives combined with cis-atracurium to induce rapid intubation.Group B only received sedatives to induce intubation.The success rate of intubation, successful intubation time were compared between the two groups.Before and after endotracheal intubation, the heart rate, mean arterial blood pressure, pulse oxygen concentration and the change of catecholamine concentration were compared. \u0000 \u0000 \u0000Results \u0000The success rate of intubation in group A was 100.0%, which in group B was 76.9%, the difference between the two groups was statistically significant (χ2=12.15, P 0.05). The serum adrenaline level was higher compared with before intubation, but there was no statistically significant difference (t=-1.03, P>0.05). In group B, the pulse oxygen concentration was significantly increased after intubation compared with before intubation (t=5.74, P 0.05). \u0000 \u0000 \u0000Conclusion \u0000In the airway management of critically ill patients in emergency department, the application of sedatives combined with cis-atracurium to rapidly induce intubation can improve the hypoxia symptoms of patients more rapidly and can keep patients' hemodynamics, catecholamine concentration is relatively stable, it has the characteristics of safety and efficiency. \u0000 \u0000 \u0000Key words: \u0000Emergency service, hospital; Emergencies; Critical illness; Airway management; Intubation, intratracheal; Atracurium; Hypnotics and sedatives; Hemodynamics","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47908330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-15DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.06.013
X. Bao, Qun Wang
Objective To explore the application value of 16-slice spiral CT multi-planar reconstruction(MPR), surface occlusion display and other image post-processing techniques in the diagnosis of peripheral lung cancer. Methods From April 2017 to April 2019, a total of 98 patients with peripheral lung cancer admitted to the Affiliated Hospital of Hangzhou Normal University and the First People's Hospital of Jiashan County were selected.The detection rates of various signs of MPR, surface occlusion display and other image post-processing techniques in the diagnosis of peripheral lung cancer were analyzed and compared. Results MPR in the diagnosis of peripheral lung cancer, the lobulated sign was 94.9%(93/98), the vascular bundle sign was 85.7%(84/98), the fine and short burr was 93.9%(92/98). The detection rate of vascular bundle sign and fine burr sign was higher than that of thin layer scan (χ2=5.351, 5.023, 5.777, all P 0.05). The surface occlusion in the diagnosis of peripheral lung cancer, showed 90.8%(89/98) lobulated sign and 74.5%(73/98) pleural indentation.The detection rates of lobulated sign and pleural sag were higher than those of thin layer scanning (χ2=5.450, 6.002, all P 0.05). Conclusion In the diagnosis of various signs of peripheral lung cancer, the detection rate of 16-slice spiral CT MPR technique is high and worthy of application. Key words: Tomography, spiral computed; Lung neoplasms; Image processing, computer-assisted; Multi-plane reconstruction technology; Surface occlusion display
{"title":"Application value of 16-slice spiral CT multi-planar reconstruction, surface occlusion display and other image post-processing techniques in the diagnosis of peripheral lung cancer","authors":"X. Bao, Qun Wang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.013","url":null,"abstract":"Objective \u0000To explore the application value of 16-slice spiral CT multi-planar reconstruction(MPR), surface occlusion display and other image post-processing techniques in the diagnosis of peripheral lung cancer. \u0000 \u0000 \u0000Methods \u0000From April 2017 to April 2019, a total of 98 patients with peripheral lung cancer admitted to the Affiliated Hospital of Hangzhou Normal University and the First People's Hospital of Jiashan County were selected.The detection rates of various signs of MPR, surface occlusion display and other image post-processing techniques in the diagnosis of peripheral lung cancer were analyzed and compared. \u0000 \u0000 \u0000Results \u0000MPR in the diagnosis of peripheral lung cancer, the lobulated sign was 94.9%(93/98), the vascular bundle sign was 85.7%(84/98), the fine and short burr was 93.9%(92/98). The detection rate of vascular bundle sign and fine burr sign was higher than that of thin layer scan (χ2=5.351, 5.023, 5.777, all P 0.05). The surface occlusion in the diagnosis of peripheral lung cancer, showed 90.8%(89/98) lobulated sign and 74.5%(73/98) pleural indentation.The detection rates of lobulated sign and pleural sag were higher than those of thin layer scanning (χ2=5.450, 6.002, all P 0.05). \u0000 \u0000 \u0000Conclusion \u0000In the diagnosis of various signs of peripheral lung cancer, the detection rate of 16-slice spiral CT MPR technique is high and worthy of application. \u0000 \u0000 \u0000Key words: \u0000Tomography, spiral computed; Lung neoplasms; Image processing, computer-assisted; Multi-plane reconstruction technology; Surface occlusion display","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42526266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-15DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.06.004
Yunfei Cao, Shaoping Zhong, Q. Ma
Objective To investigate the clinical application of placental growth factor (PLGF) combined with uterine artery pulsation index in predicting early-onset preeclampsia. Methods From March 2018 to March 2019, 69 cases of early-onset preeclampsia in the Maternal and Child Health Hospital of Jiaxing were selected as observation group, including 37 cases in mild group and 32 cases in severe group.And 58 cases of normal pregnant women in our hospital from March 2018 to March 2019 were selected as control group.The changes of plasma PLGF and uterine artery index, the changes of plasma PLGF and uterine artery index in different degrees of illness, and the diagnostic sensitivity and specificity of PLGF combined with uterine artery index were compared between the two groups. Results The level of plasma PLGF in the observation group was (1.29±0.25)μg/L, which was lower than that in the control group[(1.70±0.34)μg/L](t=7.816, P<0.05). The PI (1.48±0.31), RI (0.83±0.12) and S/D(2.97±0.65) of the observation group were higher than those of the control group[(0.91±0.18), (0.58±0.09) and (1.71±0.53)](t=12.357, 13.071, 11.823, all P<0.05). The level of PLGF in the severe group was (1.13±0.27)μg/L, which was lower than that in the mild group[(1.45±0.23)μg/L](t=5.317, P<0.05). The PI(1.71±0.36), RI(0.97±0.14) and S/D(3.45±0.71) in the severe group were higher than those in the mild group[(1.16±0.24), (0.72±0.10) and (2.43±0.57)](t=7.556, 8.618, 6.616, all P<0.05). The diagnostic sensitivity and specificity of PLGF combined with uterine pulsation index were higher than those of PLGF and uterine pulsation index alone. Conclusion PLGF combined with uterine pulsation index can predict the condition of early-onset preeclampsia, and the combination can improve the sensitivity and specificity. Key words: Eclampsia; Placenta; Uterine artery; Pulsatile flow; Vascular resistance; Sensitivity and specificity
{"title":"Clinical application of PLGF combined with uterine artery pulse index in predicting early-onset preeclampsia","authors":"Yunfei Cao, Shaoping Zhong, Q. Ma","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.004","url":null,"abstract":"Objective \u0000To investigate the clinical application of placental growth factor (PLGF) combined with uterine artery pulsation index in predicting early-onset preeclampsia. \u0000 \u0000 \u0000Methods \u0000From March 2018 to March 2019, 69 cases of early-onset preeclampsia in the Maternal and Child Health Hospital of Jiaxing were selected as observation group, including 37 cases in mild group and 32 cases in severe group.And 58 cases of normal pregnant women in our hospital from March 2018 to March 2019 were selected as control group.The changes of plasma PLGF and uterine artery index, the changes of plasma PLGF and uterine artery index in different degrees of illness, and the diagnostic sensitivity and specificity of PLGF combined with uterine artery index were compared between the two groups. \u0000 \u0000 \u0000Results \u0000The level of plasma PLGF in the observation group was (1.29±0.25)μg/L, which was lower than that in the control group[(1.70±0.34)μg/L](t=7.816, P<0.05). The PI (1.48±0.31), RI (0.83±0.12) and S/D(2.97±0.65) of the observation group were higher than those of the control group[(0.91±0.18), (0.58±0.09) and (1.71±0.53)](t=12.357, 13.071, 11.823, all P<0.05). The level of PLGF in the severe group was (1.13±0.27)μg/L, which was lower than that in the mild group[(1.45±0.23)μg/L](t=5.317, P<0.05). The PI(1.71±0.36), RI(0.97±0.14) and S/D(3.45±0.71) in the severe group were higher than those in the mild group[(1.16±0.24), (0.72±0.10) and (2.43±0.57)](t=7.556, 8.618, 6.616, all P<0.05). The diagnostic sensitivity and specificity of PLGF combined with uterine pulsation index were higher than those of PLGF and uterine pulsation index alone. \u0000 \u0000 \u0000Conclusion \u0000PLGF combined with uterine pulsation index can predict the condition of early-onset preeclampsia, and the combination can improve the sensitivity and specificity. \u0000 \u0000 \u0000Key words: \u0000Eclampsia; Placenta; Uterine artery; Pulsatile flow; Vascular resistance; Sensitivity and specificity","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43986570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To observe the changes in bone density and calcium and phosphorus metabolism indicators in elderly patients with advanced schistosomiasis liver disease after splenectomy. Method: 118 patients with advanced schistosomiasis liver disease who were hospitalized at the Third People's Hospital of Kunshan City from January 2017 to July 2018 were included in the study group. 81 patients who underwent splenectomy were included in the observation group, and 37 patients who did not undergo splenectomy were included in the control group. Compare the differences in B-ultrasound bone density values, Asian Osteoporosis Self Screening Tool (OSTA) scores, and indicators such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum albumin (ALB), fibrinogen (FBG), lactate dehydrogenase (LDH), calcium, phosphorus, parathyroid hormone (PTH), and 25-hydroxyvitamin D between two groups of patients. The results showed that the B-ultrasound velocity (SOS) and T-values of the observation group were (3926.6 ± 143.4) m/s and (-2.12 ± 1.35), respectively, which were significantly higher than those of the control group (3832.0 ± 151.4) m/s and (-3.12 ± 1.33) (t=3.27 and 3.78, both P 0.05). The AST and ALT levels in the observation group were (34.04 ± 11.81) U/L and (21.53 ± 8.73) U/L, respectively, significantly higher than those in the control group (26.19 ± 5.78) U/L and (14.00 ± 4.89) U/L (t=3.83, 4.90, P 0.05). Observation group 25 hydroxyvitamin D [(24.06 ± 6.99) μ G/L] significantly higher than the control group [(21.36 ± 6.50) μ G/L] (t=1.99, P<0.05). Conclusion: Elderly patients with advanced schistosomiasis liver disease lack vitamin D, and their bone density after splenectomy is significantly higher than that of patients without splenectomy. There is no significant change in calcium and phosphorus metabolism indicators.
{"title":"Changes of bone density, serum calcium and phosphorus in elderly schistosomiasis hepatopathy patients in advanced stage after splenectomy","authors":"Wenjian Guo, Yongsong Xie","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.023","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.023","url":null,"abstract":"目的 \u0000观察老年晚期血吸虫肝病脾切除术后患者骨密度及钙磷代谢指标的变化。 \u0000 \u0000 \u0000方法 \u0000纳入2017年1月至2018年7月在昆山市第三人民医院住院治疗的晚期血吸虫肝病患者118例，脾切除术后患者81例为观察组，未行脾切除术的患者37例为对照组。比较两组患者的B超骨密度值、亚洲人骨质疏松自我筛查工具(OSTA)评分及天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、血清白蛋白(ALB)、纤维蛋白原(FBG)、乳酸脱氢酶(LDH)、钙、磷、甲状旁腺激素(PTH)、25-羟维生素D等指标的差异。 \u0000 \u0000 \u0000结果 \u0000观察组B超声波速率(SOS)值、T值分别为(3 926.6±143.4)m/s、(－2.12±1.35)，明显高于对照组的(3 832.0±151.4)m/s、(－3.12±1.33)(t＝3.27、3.78，均P 0.05)。观察组AST、ALT分别为(34.04±11.81)U/L、(21.53±8.73)U/L，均明显高于对照组的(26.19±5.78)U/L、(14.00±4.89)U/L(t＝3.83、4.90，P 0.05)。观察组25-羟维生素D[(24.06±6.99)μg/L]明显高于对照组[(21.36±6.50)μg/L](t＝1.99，P<0.05)。 \u0000 \u0000 \u0000结论 \u0000老年晚期血吸虫肝病患者维生素D缺乏，脾切除术后患者的骨密度明显高于未行脾切除的患者，钙磷代谢指标无明显变化。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43633062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-15DOI: 10.3760/CMA.J.ISSN.1008-6706.2020.06.002
Yong Zhu, Xiao-juan Zheng, Zhenzhen Zhu, Hui-Min Teng, Feifei Ni
Objective To investigate the clinical effect of hysteroscopic scar excision for cesarean scar pregnancy(CSP) and its effect on serum β-human chorionic gonadotropin(β-HCG). Methods From January 2017 to January 2019, 83 patients with endogenous CSP admitted to the People's Hospital of Wenzhou were divided into observation group(43 cases) and control group(40 cases) according to different surgical methods.The observation group underwent hysteroscopic scar lesion resection, while the control group underwent uterine artery embolization.The success rate, intraoperative bleeding volume, vaginal bleeding time and hospitalization time, postoperative complications and the recovery time of blood β-HCG were compared between the two groups. Results The success rate of operation in the observation group was 97.67%(42/43), which was higher than that in the control group[82.50%(33/40)](χ2=3.875, P 0.05). The recovery time of blood β-HCG in the observation group[(19.54±3.52)d]was shorter than that in the control group[(28.73±6.57)d](t=8.020, P<0.05). The total satisfaction rate of the observation group was 97.67%(42/43), which was higher than 77.50%(31/40) of the control group(χ2=6.170, P<0.05). Conclusion Hysteroscopy-assisted scar excision is effective in the treatment of CSP, and can shorten the recovery time of blood β-HCG. Key words: Hysteroscopy; Cicatrix; Cesarean section; Pregnancy, ectopic; Chorionic gonadotropin, beta subunit, human; Uterine hemorrhage; Postoperative complications; Patient satisfaction
{"title":"Clinical study of hysteroscopic resection for cesarean scar pregnancy","authors":"Yong Zhu, Xiao-juan Zheng, Zhenzhen Zhu, Hui-Min Teng, Feifei Ni","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.002","url":null,"abstract":"Objective \u0000To investigate the clinical effect of hysteroscopic scar excision for cesarean scar pregnancy(CSP) and its effect on serum β-human chorionic gonadotropin(β-HCG). \u0000 \u0000 \u0000Methods \u0000From January 2017 to January 2019, 83 patients with endogenous CSP admitted to the People's Hospital of Wenzhou were divided into observation group(43 cases) and control group(40 cases) according to different surgical methods.The observation group underwent hysteroscopic scar lesion resection, while the control group underwent uterine artery embolization.The success rate, intraoperative bleeding volume, vaginal bleeding time and hospitalization time, postoperative complications and the recovery time of blood β-HCG were compared between the two groups. \u0000 \u0000 \u0000Results \u0000The success rate of operation in the observation group was 97.67%(42/43), which was higher than that in the control group[82.50%(33/40)](χ2=3.875, P 0.05). The recovery time of blood β-HCG in the observation group[(19.54±3.52)d]was shorter than that in the control group[(28.73±6.57)d](t=8.020, P<0.05). The total satisfaction rate of the observation group was 97.67%(42/43), which was higher than 77.50%(31/40) of the control group(χ2=6.170, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Hysteroscopy-assisted scar excision is effective in the treatment of CSP, and can shorten the recovery time of blood β-HCG. \u0000 \u0000 \u0000Key words: \u0000Hysteroscopy; Cicatrix; Cesarean section; Pregnancy, ectopic; Chorionic gonadotropin, beta subunit, human; Uterine hemorrhage; Postoperative complications; Patient satisfaction","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44069393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To observe the clinical effect of ultrasound guided sclerotherapy for thyroid cystic solid nodules. Method: 49 patients with thyroid nodules (57 cystic solid nodules) admitted to Jincheng Coal Industry Group General Hospital from July 2016 to June 2019 were selected for ultrasound guided sclerotherapy. The treatment effect, changes in nodule volume before and after treatment, and adverse reactions were analyzed. After ultrasound guided sclerotherapy, 51 out of 57 cystic solid nodules were effective, with a total effective rate of 89.5%; The volume of nodules before treatment was (12.4 ± 5.2) cm3, and the volume after treatment was (2.8 ± 3.1) cm3. There was a statistically significant difference before and after treatment (t=11.97, P<0.05); Among the 49 patients, 2 experienced pain and 1 experienced intraoperative bleeding, with a complication rate of 6.1% (3/49). Conclusion: Ultrasound guided sclerotherapy for thyroid cystic solid nodules is effective, easy to operate, and has no serious complications.
{"title":"Effect of ultrasound-guided sclerotherapy on solid nodules of thyroid cyst","authors":"Xiaolin Zhang, J. Lu, Weijie Zhao, Nana Xin, Jianzhong Ding","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.021","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.021","url":null,"abstract":"目的 \u0000观察超声引导下硬化治疗甲状腺囊实性结节的临床效果。 \u0000 \u0000 \u0000方法 \u0000选取晋城煤业集团总医院2016年7月至2019年6月收治的甲状腺结节患者49例(57个囊实性结节)，进行超声引导下硬化治疗，分析治疗效果、治疗前后结节体积的变化及不良反应。 \u0000 \u0000 \u0000结果 \u0000经过超声引导下硬化治疗，57个囊实性结节有效51个，总有效率为89.5%；治疗前结节体积(12.4±5.2)cm3，治疗后体积(2.8±3.1)cm3，治疗前后差异有统计学意义(t＝11.97，P<0.05)；49例患者中出现疼痛2例，术中出血1例，并发症发生率为6.1%(3/49)。 \u0000 \u0000 \u0000结论 \u0000超声引导下硬化治疗甲状腺囊实性结节疗效确切，操作简单，无严重并发症。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43058059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：