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Knowledge of rabies prophylaxis among junior doctors in a tertiary hospital in Manipur – A cross-sectional study 曼尼普尔一家三级医院初级医生的狂犬病预防知识——一项横断面研究
Pub Date : 2023-04-01 DOI: 10.4103/cjhr.cjhr_100_22
Kh Singh, Vijaya Elangbam, Toijam Singh
Context: Rabies, a zoonotic disease caused by Lyssavirus genus rabies virus, is 100% fatal yet preventable. Appropriate and timely management of rabies cases will help in reducing and preventing mortality. Health-care personnel, especially the junior doctors who are at the threshold of their public health service, need to be equipped with adequate knowledge to be able to provide effective care. Aims: The aims of the study are to assess the knowledge about rabies and to assess the association between knowledge with sociodemographic characteristics among the junior doctors of a tertiary care hospital, Imphal. Settings and Design: A cross-sectional study was conducted among 520 junior doctors of a tertiary care hospital including interns, house officers, and postgraduate trainees from June 2018 to July 2019. Subjects and Methods: Data collection was done by questionnaire method. Statistical Analysis Used: The data were analyzed using IBM SPSS for Windows, Version 21.0. Armonk, NY, USA. Results: Only 17.5% of the junior doctors had adequate knowledge about rabies. Those who had come across and those who had treated rabies were 35.4% and 23.7%, respectively. Only around half of the respondents knew the management of the WHO Category I and III animal bite exposure. Conclusions: In the present study, it was seen that the overall knowledge of the junior doctors was poor. Only 2 out of 10 of the participants had adequate knowledge of rabies. One-fourth of the participants had treated rabies in their clinical practice and those who had treated rabies had better knowledge compared to those respondents who had never treated.
背景:狂犬病是一种由狂犬病毒属狂犬病病毒引起的人畜共患疾病,是100%致命但可预防的。适当和及时地处理狂犬病病例将有助于减少和预防死亡率。保健人员,特别是刚开始从事公共保健服务的初级医生,需要具备足够的知识,以便能够提供有效的护理。目的:本研究的目的是评估关于狂犬病的知识,并评估知识与社会人口学特征之间的关系在英帕尔三级保健医院初级医生。设置与设计:本研究于2018年6月至2019年7月对某三级医院的520名初级医生进行了横断面研究,包括实习生、住院医生和研究生实习生。对象与方法:采用问卷调查法收集资料。使用统计分析:采用IBM SPSS for Windows, Version 21.0对数据进行分析。阿蒙克,纽约州,美国结果:初级医师对狂犬病知识有充分了解的仅占17.5%。感染狂犬病及接受狂犬病治疗者分别占35.4%及23.7%。只有大约一半的答复者知道世卫组织第一类和第三类动物咬伤暴露的管理。结论:在本研究中,初级医生的整体知识水平较差。只有2 / 10的参与者有足够的狂犬病知识。四分之一的参与者在临床实践中治疗过狂犬病,那些治疗过狂犬病的人比那些从未治疗过的受访者有更好的知识。
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引用次数: 0
Hippocratic oath in dentistry: An insight 希波克拉底誓言在牙科:一个见解
Pub Date : 2023-04-01 DOI: 10.4103/cjhr.cjhr_77_21
Deepti Sharma, G. Koshy, Ria Merin, A. Alexander, Gauri Malik, V. Sharma
The hippocratic values on health profession target holistic patient care model and lay down the foundation of standards and ethical rules that are still convincing today. Despite various agreements or disagreements regarding its relevance in modern era, it reflects the soul of health profession. Various versions of the oath are available and followed by medical and dental students as they begin their professional journey. The vows are commitments made to the society, colleagues, and disciples to develop mutual trust and avoid the exploitation. The principles of oath may guide us when we are at the dead end of dark tunnel in our professional careers. In dentistry, the code of ethics is outlined by the hippocratic oath which inspires the dental professional to carry out their duties justly and ethically. This review attempts to discuss the relevance of hippocratic oath in dentistry and emphasizes on the need to have standardized oath for dental graduates.
健康职业的希波克拉底价值观以整体患者护理模式为目标,并为今天仍然令人信服的标准和道德规则奠定了基础。尽管对其在现代的相关性有各种各样的共识或分歧,但它反映了卫生专业的灵魂。医学和牙科专业的学生在开始他们的职业之旅时,可以使用各种版本的宣誓书。誓言是对社会、同事和弟子做出的承诺,以发展相互信任并避免剥削。当我们在职业生涯中处于黑暗隧道的尽头时,誓言的原则可能会指导我们。在牙科中,希波克拉底誓言概述了道德准则,激励牙科专业人员公正、合乎道德地履行职责。这篇综述试图讨论希波克拉底誓言在牙科中的相关性,并强调对牙科毕业生进行标准化宣誓的必要性。
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引用次数: 0
Occupational stress: An impediment to quality nurse–Patient relationship – A rapid review 职业压力:高质量护患关系的障碍——快速回顾
Pub Date : 2023-04-01 DOI: 10.4103/cjhr.cjhr_66_22
O. Akpor, Aina Olusayo, O. Olorunfemi
Given the complex nature of the effect of occupational stress also known as work or job stress, on the quality of nurse- patient relationship, it appears a daunting task reaching a unified definition of work stress because of the acknowledged fact that a singular approach may not be able to encompass the breadth of the phenomenon. This study aims to provide a general review of some of the challenges of stress on nurse–patient relationship, and causes of occupational stress were examined in light of the conceptual typology that portrays various sources of workplace stress and strategies in preventing occupational stress. The data for this study were from published studies. Electronic databases of Medline, Scopus, PubMed, CINAHL, and Google Scholar were searched using keywords: occupational stress, nurse- patient relationship and quality of nursing care literatures were retrieved and screened for eligibility. The date limit considered in the literature search was from 2016 to 2023 to capture only the variables identified in this study objective. Stress sources are consequentially known to produce dire organization and extra-organizational outcomes such as low morale, poor performance, career uncertainty, poor care, health problems, work-life conflict, turnover, and other reverse that undermine the competitive objectives of business. Stress curative measures are discussed to assist nurses to understand the significance of providing effective stress management interventions that can enhance employee well-being and organizational productivity.
鉴于职业压力(也称为工作或工作压力)对护患关系质量的影响具有复杂的性质,达成工作压力的统一定义似乎是一项艰巨的任务,因为公认的事实是,单一的方法可能无法涵盖这种现象的广度。本研究旨在对压力对护患关系的一些挑战进行全面回顾,并根据描述工作场所压力的各种来源和预防职业压力策略的概念类型学来检查职业压力的原因。本研究的数据来自已发表的研究。使用关键词搜索Medline、Scopus、PubMed、CINAHL和Google Scholar的电子数据库:检索职业压力、护患关系和护理文献质量,并筛选合格性。文献检索中考虑的日期限制为2016年至2023年,仅涵盖本研究目标中确定的变量。众所周知,压力源会导致糟糕的组织和组织外结果,如士气低落、表现不佳、职业不确定性、护理不善、健康问题、工作与生活冲突、离职以及其他破坏企业竞争目标的逆转。讨论了压力治疗措施,以帮助护士理解提供有效的压力管理干预措施的重要性,从而提高员工的幸福感和组织生产力。
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引用次数: 0
Deep vein thrombosis in a medical ward - Incidence and risk factors 病房深静脉血栓的发生率和危险因素
Pub Date : 2023-04-01 DOI: 10.4103/cjhr.cjhr_42_21
A. Lenin, T. Sudarsanam, P. Mannam
Objectives: Primary objective: The incidence of deep vein thrombosis in patients admitted to a medical ward. Methods: We conducted a prospective cohort to assess the incidence of deep vein thrombosis in patients admitted in a medical of our tertiary care center between October 2014 and May 2015. We excluded patients who had a preexisting deep vein thrombosis or a pulmonary embolism and patients on therapeutic anticoagulation. A bedside ultrasound machine was used for screening for deep vein thrombosis in the internal jugular, axillary, femoral, and popliteal veins. Noncompressibility of the vein compared to the artery was suggestive of thrombosis. Results: Among the 43 patients included in the study, 3 (6.98%) patients developed deep vein thrombosis. The incidence density is 7.48 per 1000 patient-days. One patient developed a central venous catheter-associated deep vein thrombosis. Multivariate analysis showed that the duration of hospital stay of more than 7 days was associated with a higher risk of development of deep vein thrombosis (odds ratio: 1.17 [confidence interval: 1.016–1.349]). Conclusions: The incidence of deep vein thrombosis among patients admitted in a medical ward of a tertiary care hospital in South India was 7.48 per 1000 patient-days. Hospital admission of more than 7 days was found to be a significant independent risk factor for development of deep vein thrombosis in our study.
目的:主要目的:了解住院患者深静脉血栓形成的发生率。方法:我们进行了一项前瞻性队列研究,以评估2014年10月至2015年5月期间入住我们三级医疗中心的患者深静脉血栓形成的发生率。我们排除了先前存在深静脉血栓形成或肺栓塞的患者和接受抗凝治疗的患者。床边超声机用于筛查颈内静脉、腋静脉、股静脉和腘静脉的深静脉血栓形成。与动脉相比,静脉不可压迫性提示血栓形成。结果:在纳入研究的43名患者中,3名(6.98%)患者出现深静脉血栓形成。发病密度为7.48/1000患者日。一名患者出现中心静脉导管相关的深静脉血栓形成。多因素分析显示,住院时间超过7天与深静脉血栓形成的风险较高相关(比值比:1.17[置信区间:1.016-1.349])。在我们的研究中,超过7天的住院时间被发现是发展为深静脉血栓形成的一个重要的独立风险因素。
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引用次数: 0
Healthcare-seeking behavior and awareness regarding snakebites and its first-aid management among tribal women in rural Maharashtra 马哈拉施特拉邦农村部落妇女对毒蛇咬伤及其急救管理的寻求医疗保健行为和意识
Pub Date : 2023-04-01 DOI: 10.4103/cjhr.cjhr_143_21
Anuradha Shah, A. Sapkal, S. Deshpande
Background: In rural India, snake bite is a major health problem with high morbidity and mortality. Women have poor knowledge regarding snakebite and first aid measures and often resort to home remedies or visit traditional healers. This study was taken up to assess the healthcare-seeking behavior and awareness regarding snakebites and first-aid management among tribal women. Materials and Methods: This cross-sectional study was conducted from February to July 2019 in a tribal village, Palghar, Maharashtra. The sample size was 278. Women above the age of 18 years were selected by simple random sampling. A prevalidated semi-structured questionnaire was used for data collection which was done through door-to-door visit. Results: The mean age of the women was 36.59 years. Around 55.4% of women had good knowledge regarding snakebite and 39.9% of women had good knowledge of first aid in the event of Snakebite. Awareness regarding signs and symptoms in event of snakebite was good. The majority of the women preferred government medical facilities (71.58%) for the treatment of snakebite followed by traditional healers (20.14%). The main reasons for visiting traditional healers were transport difficulties, easy accessibility, and traditional beliefs and rituals. The most common form of first aid that was provided to the victims was tying of tight cloth/wire (72.86%), herbal medicines (30.85%), and use of “mantras” (8.17%). Conclusion: There is good knowledge regarding snakebites among tribal women, however, knowledge about appropriate first aid seems to be lacking. They are aware of the signs and symptoms and know how to prevent them however, preventive action is lacking. A targeted health education program focusing on these issues is the need of the hour.
背景:在印度农村,蛇咬伤是一个主要的健康问题,发病率和死亡率都很高。妇女对蛇咬伤和急救措施知之甚少,经常求助于家庭治疗或拜访传统治疗师。本研究旨在评估部落妇女对毒蛇咬伤和急救管理的寻求医疗保健的行为和意识。材料和方法:这项横断面研究于2019年2月至7月在马哈拉施特拉邦帕尔加尔的一个部落村庄进行。样本量为278。18岁以上的妇女是通过简单的随机抽样选出的。采用预先验证的半结构化问卷进行数据收集,通过上门访问进行。结果:女性平均年龄36.59岁。约55.4%的女性对蛇咬伤有良好的认识,39.9%的女性对发生蛇咬伤时的急救有良好的了解。对发生毒蛇咬伤时的体征和症状的认识良好。大多数妇女更喜欢政府医疗机构(71.58%)治疗毒蛇咬伤,其次是传统治疗师(20.14%)。拜访传统治疗师的主要原因是交通困难、交通便利以及传统信仰和仪式。向受害者提供的最常见的急救形式是绑紧布/线(72.86%)、草药(30.85%)和使用“咒语”(8.17%)。结论:部落妇女对蛇咬伤有很好的了解,但似乎缺乏适当的急救知识。他们知道症状和体征,知道如何预防,但缺乏预防措施。针对这些问题制定有针对性的健康教育计划是当务之急。
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引用次数: 0
Five-year outcomes and predictors of mortality following sepsis in a large cohort of patients in a general medical ward: A cohort study from South India 在普通病房的大队列患者中败血症后的5年预后和死亡率预测因素:来自南印度的队列研究
Pub Date : 2023-04-01 DOI: 10.4103/cjhr.cjhr_106_22
M. Kalimuthu, V. Chandiraseharan, Ansa Sunny, J. Lakshmanan, M. Babu, V. Turaka, T. George, Ajay Mishra, M. Gowri, T. Sudarsanam
Background: Although sepsis is a well-known cause of in-hospital mortality, data on long term outcomes are scarce. Aim: This study aims to estimate the cumulative 5-year mortality among patients with infection requiring admission. Methods: This was a cohort study done in tertiary care center in South India, with recruitment of those admitted with an infection between January 1st, 2009 and July 31st, 2014 in a medical unit. The patients were followed up by telephonic call or case record review. Kaplan–Meier survival curve was plotted and Cox-proportional hazard model was used as multivariable analysis to identify the independent risk factors of long-term mortality. Results: One thousand four hundred and fifty three patients were followed up in this cohort study. The mean survival by Kaplan–Meier survival analysis was 3.78 years (95% confidence interval [CI] 3.33, 4.22) in quick sepsis-related organ failure assessment (qSOFA) score positive patients and 6.07 years (95% CI 5.73, 6.41) in qSOFA negative patients which was statistically significant by the log-rank test. The cumulative 1-year mortality was 44.9% and 21.8% for qSOFA score of 2 or more and nonsepsis patients, respectively. The median survival of qSOFA score of 2 or more patients was 0.75 years (95% CI 0–2.1 years). The mortality among sepsis patients at discharge, 1 year, 5 and 8 years was 38.2%, 44.9%, 47.4%, and 47.8%, respectively. Cox regression analysis showed age hazard ratio (HR) 1.02 (1.01, 1.04), male gender 1.45 (1.03, 2.04), >qSOFA score HR 1.89 (1.32, 2.72), Charlson Comorbidity Index HR 1.29 (1.14, 1.46), respiratory tract infection HR 1.81 (1.10, 2.95), and inotrope requirement HR 3.24 (1.98, 5.29) were the independent predictors of long-term mortality. Conclusions: The median survival of patients with possible infection with qSOFA score of 2 or more patients was 0.75 years (95% CI 0–2.1 years). Older age, male gender, qSOFA score of 2 or more, Charlson Comorbidity Index, respiratory tract infection, and inotrope requirement HR 3.24 were the independent predictors of long-term mortality.
背景:尽管败血症是导致住院死亡率的一个众所周知的原因,但关于长期结果的数据很少。目的:本研究旨在估计需要入院的感染患者的累计5年死亡率。方法:这是一项在南印度三级护理中心进行的队列研究,招募了2009年1月1日至2014年7月31日期间在医疗单位因感染入院的患者。通过电话或病例记录回顾对患者进行随访。绘制Kaplan–Meier生存曲线,并使用Cox比例风险模型作为多变量分析,以确定长期死亡率的独立风险因素。结果:在这项队列研究中,对一千四百五十三名患者进行了随访。Kaplan–Meier生存分析显示,快速败血症相关器官衰竭评估(qSOFA)评分阳性患者的平均生存期为3.78年(95%置信区间[CI]3.33,4.22),qSOFA阴性患者的平均存活期为6.07年(95%可信区间5.73,6.41),通过对数秩检验具有统计学意义。qSOFA评分为2分或2分以上和无症状患者的1年累计死亡率分别为44.9%和21.8%。2名或2名以上患者的qSOFA评分的中位生存期为0.75年(95%CI 0-2.1年)。败血症患者出院、1年、5年和8年的死亡率分别为38.2%、44.9%、47.4%和47.8%。Cox回归分析显示,年龄风险比(HR)1.02(1.01,1.04)、男性1.45(1.03,2.04)、>qSOFA评分HR 1.89(1.32,2.72)、Charlson合并症指数HR 1.29(1.14,1.46)、呼吸道感染HR 1.81(1.102.95)和嗜酸粒细胞需求HR 3.24(1.98,5.29)是长期死亡率的独立预测因素。结论:qSOFA评分为2分或2分以上的可能感染患者的中位生存期为0.75年(95%CI 0-2.1年)。年龄较大、男性、qSOFA评分为2分或2分以上、Charlson合并症指数、呼吸道感染和嗜酸性粒细胞需求HR 3.24是长期死亡率的独立预测因素。
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引用次数: 0
COVID-19 positivity in the COVID suspect and green zones of a large emergency department during the first wave of the pandemic in South India 在南印度第一波疫情期间,一家大型急诊室的新冠肺炎疑似病例和绿区出现新冠肺炎阳性
Pub Date : 2023-04-01 DOI: 10.4103/cjhr.cjhr_134_22
S. Selvan, V. Krishnaraj, Ponnivalavan Mathiyalagan, Hepzibah Nesamani, Paul W. Kumar, Anna Paul, Karthik Gunasekaran, K. P. Prabhakar Abhilash
Background: During the COVID-19 pandemic, there was a necessary division of the emergency department (ED) into the COVID suspect zone and a green zone based on a modified “The” Christian Medical college (CMCTS). Triaging was initially done based on the epidemiological criteria and evolved into symptom-based assessment when community transmission began. Methodology: This retrospective study included all patients who were triaged in the ED from April 2020 to December 2020. Data were collected from the ED triage software and were analyzed to determine the performance of the modified triage criteria in admitting patients to the ED. Results: Forty-three thousand patients were triaged during the study. Of which 35.9% (n = 15429) were sent to the COVID suspect zone and 64.1% (n = 27571) to the green zone. Of the 8490 (55%) nasopharyngeal swab reverse transcription polymerase chain reaction (RT-PCR) tests done in the COVID suspect zone, 61.4% were positive for COVID-19 while only 9.2% (n = 274) of 2866 tested in the green zone were positive. COVID-19 positivity was the highest in the mid-pandemic months of July, August, and September 2020. In the COVID suspect zone, factors for predicting a negative RT-PCR result were priority 1 presentation and early and late pandemic presentations. The positive predictive value of our modified triage criteria during the pandemic was 85% with a higher accuracy during the peak of the first wave (July–September 2020). Conclusion: The modified CMCTS successfully segregated COVID-19-positive patients from the COVID-19 negative patients during the first wave of the COVID-19 in 2020. The CMCTS criteria can be easily adopted or adapted in other hospitals in India in case of future waves of COVID-19.
背景:在新冠肺炎大流行期间,急诊科(ED)有必要划分为COVID可疑区域和基于修改后的“基督教医学院”(CMCTS)的绿色区域。最初根据流行病学标准进行分类,并在社区传播开始时演变为基于症状的评估。方法:这项回顾性研究包括2020年4月至2020年12月在急诊科分诊的所有患者。从ED分诊软件中收集数据,并对其进行分析,以确定修改后的分诊标准在ED患者入院时的表现。结果:研究期间对四万三千名患者进行了分诊。其中35.9%(n=15429)被送往新冠肺炎可疑区域,64.1%(n=27571)被送往绿色区域。在新冠肺炎可疑区进行的8490次(55%)鼻咽拭子逆转录聚合酶链式反应(RT-PCR)检测中,61.4%的新冠肺炎呈阳性,而在绿区进行的2866次检测中,只有9.2%(n=274)呈阳性。新冠肺炎阳性率在2020年7月、8月和9月的疫情中期最高。在新冠肺炎疑似区,预测RT-PCR阴性结果的因素是优先1表现以及早期和晚期大流行表现。我们修改的分诊标准在疫情期间的阳性预测值为85%,在第一波疫情高峰期(2020年7月至9月)的准确率更高。结论:在2020年新冠肺炎第一波疫情期间,改良的CMCTS成功地将新冠肺炎阳性患者与新冠肺炎阴性患者分离。如果未来出现新冠肺炎疫情,印度其他医院可以很容易地采用或调整CMCTS标准。
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引用次数: 0
Standardization of objective structured practical examination in terms of validity and reliability in biochemistry: Our first experience 从生物化学效度和信度的角度规范客观结构化实践考试:我们的第一次经验
Pub Date : 2023-04-01 DOI: 10.4103/cjhr.cjhr_133_22
S. Suneja
Objective: The present study is an effort to standardize and establish the validity and reliability of objective structured practical examination (OSPE) as a formative assessment tool in biochemistry. Materials and Methods: After institutional ethical clearance, brainstorming was done to plan the logistics necessary for the standardization of OSPE in biochemistry at undergraduate level. An assessment blueprint was established, structured checklists for individual procedure stations along with the student's and examiners' instruction manuals were designed. Review and revision of the planned OSPE stations were done and the validity and reliability of the tool were established. The internal reliability of the OSPE stations was determined by calculating Cronbach's alpha from the mean scores obtained by the students in each station during the formative assessments. A pilot study was conducted on a group of 14 volunteer students to establish the homogeneity of the study. The content validity index (CVI) and the coefficient of reliability of the feedback questionnaire for faculty and students were calculated. Feedback taken from students and faculty was analyzed through the Satisfaction Index for 5-point Likert Scale questions and thematic analysis for open-ended questions. Results: Cronbach's alpha of the OSPE questions, during the four formative assessments in sessional examinations, showed high internal consistency of 0.832, 0.861, 0.796, and 0.845. Homogeneity was determined by a split-half estimate of pilot OSPE with Cronbach's alpha value of 0.9. The S-CVI/Ave scores for the students and faculty questionnaire were 0.86 and 0.91 respectively with the internal consistency of 0.83 and 0.89. Conclusions: OSPE is a valid and reliable assessment tool after standardization that provides a structured approach to assessment and can be used for formative assessments of medical undergraduate students in biochemistry.
目的:对生物化学形成性评价工具——客观结构化实践考试(OSPE)进行规范,建立其效度和信度。材料与方法:在经过机构伦理审查后,进行头脑风暴,规划本科阶段生物化学OSPE标准化所需的后勤保障。建立了评估蓝图,为各个程序站设计了结构化的检查表以及学生和考官的指导手册。对规划的OSPE站进行了评审和修订,建立了工具的有效性和可靠性。通过计算各考点学生在形成性评估中获得的平均分的Cronbach’s alpha来确定各考点的内部信度。在一组14名志愿学生中进行了一项试点研究,以确定研究的同质性。计算了师生反馈问卷的内容效度指数(CVI)和信度系数。通过李克特5分量表问题的满意度指数和开放式问题的主题分析,对学生和教师的反馈进行了分析。结果:在会考四次形成性评价中,OSPE问题的Cronbach’s alpha值为0.832、0.861、0.796、0.845,具有较高的内部一致性。同质性是通过对试点OSPE的劈开一半估计来确定的,Cronbach's alpha值为0.9。学生和教师问卷的S-CVI/Ave得分分别为0.86和0.91,内部一致性为0.83和0.89。结论:OSPE标准化后是一种有效可靠的评价工具,提供了一种结构化的评价方法,可用于生物化学医学本科学生的形成性评价。
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引用次数: 0
Antitoxic principles from Moringa oleifera (Mo11) and Musa sapientum (Ms06) ameliorated cadmium chloride-induced renal hyperplasia and apoptosis through Ki67/P53-mediated pathway in rats 辣木(Mo11)和Musa sapientum(Ms06)的抗毒作用通过Ki67/P53介导的途径改善氯化镉诱导的大鼠肾脏增生和细胞凋亡
Pub Date : 2023-04-01 DOI: 10.4103/cjhr.cjhr_10_22
A. Akinlolu, Mubarak Oloduowo Ameen, G. Ebito, N. Asogwa, R. Akindele, B. Fagbohunka, Zainab Arowolo, T. Garuba
Background: Cadmium (Cd) is an established carcinogen. Cd-induced renotoxicity resulted in oxidative stress, loss of excretory kidney functions, and apoptosis of murine kidney cells. Objectives: This study evaluated renoprotective potentials of MO11 (isolated from Moringa oleifera leaves) and MS06 (isolated from Musa sapientum suckers) against Cd chloride (CdCl2)-induced renotoxicity, renal hyperplasia, and apoptosis in rats. Materials and Methods: Twenty-four adult male Wistar rats (average weight of 155 g) were randomly divided into seven groups (n = 4). Group 1 received physiological saline. Groups 2–4 and 6 received single intraperitoneal (i.p) administration of 1.5 mg/kg body weight of CdCl2 (i.p) (Day 1). Groups 3–4 and 6 were posttreated with 15 mg/kg body weight of MO11, 15 mg/kg body weight of MO11 +7 mg/kg body weight of MS06, and 3.35 mg/kg body weight of doxorubicin, respectively (days: 1–17). Group 5 received only olive oil dose (vehicle), respectively (days: 1–17). Kidney histopathology (hematoxylin and eosin technique) and enzyme-linked immunosorbent assay concentrations of biomarkers of proliferation (Ki67) and apoptosis (p53) in kidney homogenates of rats of Groups 1–6 were evaluated. Results: Histopathological analyses showed normal kidney histology in the rats of Groups 1–6. Posttreatments of CdCl2-induced renotoxicity with MO11, MO11+MS06, and doxorubicin resulted in downregulations of Ki67 and p53 in Groups 3, 4, and 6 as compared with Group 2. Conclusion: MO11 and MS06 possess renoprotective, anti-proliferation, and anti-apoptosis potentials.
背景:镉(Cd)是一种公认的致癌物质。镉诱导的肾毒性导致氧化应激、排泄肾功能丧失和小鼠肾细胞凋亡。目的:本研究评估了MO11(从辣木叶中分离)和MS06(从Musa sapientum suckers中分离)对氯化镉(CdCl2)诱导的大鼠肾毒性、肾增生和细胞凋亡的肾保护作用。材料和方法:24只成年雄性Wistar大鼠(平均体重155g)随机分为7组(n=4)。第1组接受生理盐水。第2-4组和第6组接受1.5 mg/kg体重CdCl2的单次腹膜内(i.p)给药(第1天)。第3-4组和第6组分别用15 mg/kg体重的MO11、15 mg/kg重量的MO11+7 mg/kg体重的MS06和3.35 mg/kg体重的阿霉素进行后处理(第1-17天)。第5组分别只接受橄榄油剂量(载体)(第1-17天)。评估了1-6组大鼠肾匀浆中增殖(Ki67)和凋亡(p53)生物标志物的肾脏组织病理学(苏木精和伊红技术)和酶联免疫吸附测定浓度。结果:组织病理学分析显示1-6组大鼠肾脏组织学正常。与第2组相比,用MO11、MO11+MS06和阿霉素对CdCl2诱导的肾毒性进行后处理导致第3、4和6组Ki67和p53的下调。结论:MO11和MS06具有肾保护、抗增殖和抗细胞凋亡的作用。
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引用次数: 0
A descriptive study on online health information-seeking behavior among adults attending a tertiary care hospital in central Kerala 喀拉拉邦中部一家三级医院成人在线健康信息寻求行为的描述性研究
Pub Date : 2023-04-01 DOI: 10.4103/cjhr.cjhr_64_21
S. Sebastian, VT Anjusha Joseph, AnnElizabeth Sibichen
Background: The internet plays a crucial role in educating and empowering the health consumer, by providing a large quantity of information on health and health services at their convenience. Although people pay attention to the health information available online, they seldom remember the source of information or are mindful about the credibility of internet sites. As a consequence, online information can lead to patients being misinformed, a sense of distress, and an increase in the tendency toward self-diagnosis or self-treatment. Aim: This study aims to study the pattern of seeking online health information among adults attending a Tertiary Care Hospital in Central Kerala. Materials and Methods: A hospital-based cross-sectional study was conducted among 460 adults attending a tertiary care hospital in central Kerala. Results: Sixty-six percent of the study participants surfed the Internet to gather information about symptoms related to their condition. Forty-one percent of the study population preferred to discuss the information with their doctor. Majority of study subjects (58%) preferred better opportunities for doubt clearance with their consulting doctor instead of googling their symptoms. Conclusion: The present study recommends that online health information should be used in synergy with doctor–patient interactions which give them viable and true information to cope with their problems to disseminate the right knowledge in the community.
背景:互联网在卫生消费者方便时提供大量卫生和卫生服务信息,在教育和增强消费者权能方面发挥着至关重要的作用。虽然人们关注网上可获得的健康信息,但他们很少记得信息的来源或注意到网站的可信度。因此,在线信息可能导致患者被误导,产生痛苦感,并增加自我诊断或自我治疗的倾向。目的:本研究旨在研究喀拉拉邦中部一家三级护理医院的成年人在线寻求健康信息的模式。材料和方法:在喀拉拉邦中部一家三级保健医院的460名成年人中进行了一项基于医院的横断面研究。结果:66%的研究参与者上网收集与他们的病情相关的症状信息。41%的研究对象更愿意与他们的医生讨论这些信息。大多数研究对象(58%)宁愿有更好的机会向他们的咨询医生澄清疑虑,而不是在谷歌上搜索他们的症状。结论:本研究建议将网络健康信息与医患互动相结合,为他们提供可行的、真实的信息,以解决他们的问题,并在社区中传播正确的知识。
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CHRISMED Journal of Health and Research
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